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Aliases for ELOA2 Gene

Aliases for ELOA2 Gene

  • Elongin A2 2 3
  • Transcription Elongation Factor B Subunit 3B 2 3 5
  • TCEB3B 3 4 5
  • Transcription Elongation Factor B Polypeptide 3B 3 4
  • TCEB3L 3 4
  • Transcription Elongation Factor B Polypeptide 3B (Elongin A2) 2
  • Transcription Elongation Factor (SIII) Elongin A2 Elongin A2 3
  • RNA Polymerase II Transcription Factor SIII Subunit A2 3
  • Transcription Elongation Factor (SIII) Elongin A2 2
  • Elongin-A2 4
  • HsT832 3
  • EloA2 4

External Ids for ELOA2 Gene

Previous HGNC Symbols for ELOA2 Gene

  • TCEB3B

Summaries for ELOA2 Gene

Entrez Gene Summary for ELOA2 Gene

  • This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELOA2 Gene

ELOA2 (Elongin A2) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Gene Expression. An important paralog of this gene is ELOA3.

UniProtKB/Swiss-Prot for ELOA2 Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOA2 Gene

Genomics for ELOA2 Gene

Regulatory Elements for ELOA2 Gene

Enhancers for ELOA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F046939 0.9 Ensembl ENCODE 10.9 +95.6 95572 2.1 PKNOX1 JUN CEBPB ZFP37 SIN3A JUND FOS PRDM1 KATNAL2 ELOA3 ELOA2 IER3IP1 HDHD2 GC18P046926 ELOA3D
GH18F046898 0.4 ENCODE 10.4 +136.2 136170 1.3 TEAD4 PRDM1 ELOA2 ELOA3 IER3IP1 HDHD2 ENSG00000279354 LOC100421737
GH18F047405 0.3 FANTOM5 1.2 -369.8 -369833 0.0 ELOA2 MIR4527 ENSG00000261307 ENSG00000279367
GH18F047075 0.9 Ensembl ENCODE 0.3 -39.8 -39766 0.4 KLF1 MAZ RFX5 ZNF664 JUND KLF9 ZNF580 FOXP2 PRDM10 IER3IP1 HDHD2 ENSG00000280212 ELOA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELOA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELOA2 Gene

Chromosome:
18
Start:
47,032,572 bp from pter
End:
47,035,621 bp from pter
Size:
3,050 bases
Orientation:
Minus strand

Genomic View for ELOA2 Gene

Genes around ELOA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOA2 Gene

Proteins for ELOA2 Gene

  • Protein details for ELOA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYF1-ELOA2_HUMAN
    Recommended name:
    RNA polymerase II transcription factor SIII subunit A2
    Protein Accession:
    Q8IYF1
    Secondary Accessions:
    • Q9P2V9

    Protein attributes for ELOA2 Gene

    Size:
    753 amino acids
    Molecular mass:
    83921 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit.

neXtProt entry for ELOA2 Gene

Post-translational modifications for ELOA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELOA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELOA2 Gene

Domains & Families for ELOA2 Gene

Suggested Antigen Peptide Sequences for ELOA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYF1

UniProtKB/Swiss-Prot:

ELOA2_HUMAN :
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
  • Contains 1 TFIIS N-terminal domain.
genes like me logo Genes that share domains with ELOA2: view

No data available for Gene Families for ELOA2 Gene

Function for ELOA2 Gene

Molecular function for ELOA2 Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Gene Ontology (GO) - Molecular Function for ELOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ELOA2: view
genes like me logo Genes that share phenotypes with ELOA2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ELOA2 Gene

Localization for ELOA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ELOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016021 integral component of membrane IEA --
GO:0070449 elongin complex IBA --
genes like me logo Genes that share ontologies with ELOA2: view

Pathways & Interactions for ELOA2 Gene

genes like me logo Genes that share pathways with ELOA2: view

Gene Ontology (GO) - Biological Process for ELOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10692460
GO:0006368 transcription elongation from RNA polymerase II promoter IBA --
GO:0032784 regulation of DNA-templated transcription, elongation TAS 10692460
genes like me logo Genes that share ontologies with ELOA2: view

No data available for SIGNOR curated interactions for ELOA2 Gene

Transcripts for ELOA2 Gene

mRNA/cDNA for ELOA2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ELOA2 Gene

Transcription elongation factor B polypeptide 3B (elongin A2):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELOA2 Gene

No ASD Table

Relevant External Links for ELOA2 Gene

GeneLoc Exon Structure for
ELOA2
ECgene alternative splicing isoforms for
ELOA2

Expression for ELOA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOA2 Gene:

ELOA2

SOURCE GeneReport for Unigene cluster for ELOA2 Gene:

Hs.375035

mRNA Expression by UniProt/SwissProt for ELOA2 Gene:

Q8IYF1-ELOA2_HUMAN
Tissue specificity: Specifically expressed in testis.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ELOA2 Gene

Orthologs for ELOA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELOA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB3B 34 35
  • 97.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves TCEB3 35
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tceb3 35
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EloA 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03D7.4 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for ELOA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ELOA2 Gene

ENSEMBL:
Gene Tree for ELOA2 (if available)
TreeFam:
Gene Tree for ELOA2 (if available)

Paralogs for ELOA2 Gene

Paralogs for ELOA2 Gene

genes like me logo Genes that share paralogs with ELOA2: view

Variants for ELOA2 Gene

Sequence variations from dbSNP and Humsavar for ELOA2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs138369139 A colorectal cancer sample 47,033,772(+) CCTCC(C/T)GGAAC intron-variant, reference, missense
rs193920804 Uncertain significance 47,034,898(-) GCCCA(C/T)CTCAC intron-variant, reference, missense
rs111815744 -- 47,034,156(+) TATCT(A/C/G)CCTCC intron-variant, reference, missense
rs112917651 -- 47,036,827(+) ATTCA(A/G/T)TAAAT intron-variant, upstream-variant-2KB
rs112920514 -- 47,034,612(+) CGGCT(C/T)TCCCC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ELOA2 Gene

Variant ID Type Subtype PubMed ID
esv998188 CNV gain 20482838
nsv1056744 CNV gain 25217958
nsv2284 CNV insertion 18451855
nsv509693 CNV insertion 20534489
nsv828225 CNV gain 20364138
nsv833640 CNV loss 17160897
nsv9629 CNV gain+loss 18304495

Variation tolerance for ELOA2 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELOA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOA2 Gene

Disorders for ELOA2 Gene

Relevant External Links for ELOA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA2

No disorders were found for ELOA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOA2 Gene

Publications for ELOA2 Gene

  1. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. (PMID: 10692460) Aso T. … Hatakeyama M. (J. Biol. Chem. 2000) 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PMID: 7660129) Aso T. … Conaway R.C. (Science 1995) 2 3 64
  4. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. (PMID: 8244996) Bradsher J.N. … Conaway J.W. (J. Biol. Chem. 1993) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ELOA2 Gene

Sources for ELOA2 Gene

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