Aliases for ELOA Gene
External Ids for ELOA Gene
Previous HGNC Symbols for ELOA Gene
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ELOA Gene
ELOA (Elongin A) is a Protein Coding gene. Diseases associated with ELOA include Renal Cell Carcinoma, Papillary. Among its related pathways are HIV Life Cycle and Formation of HIV elongation complex in the absence of HIV Tat. An important paralog of this gene is ELOA2.
UniProtKB/Swiss-Prot for ELOA Gene
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).