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Aliases for ELOA Gene

Aliases for ELOA Gene

  • Elongin A 2 3 5
  • Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit A1 3 4
  • Transcription Elongation Factor B Polypeptide 3 3 4
  • Transcription Elongation Factor B Subunit 3 2 3
  • Elongin 110 KDa Subunit 3 4
  • SIII P110 3 4
  • TCEB3 3 4
  • Transcription Elongation Factor B Alpha Subunit 3
  • Elongin-A 3
  • TCEB3A 3
  • SIII 3
  • EloA 4

External Ids for ELOA Gene

Previous HGNC Symbols for ELOA Gene

  • TCEB3

Summaries for ELOA Gene

Entrez Gene Summary for ELOA Gene

  • This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELOA Gene

ELOA (Elongin A) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Gene Expression. An important paralog of this gene is ELOA2.

UniProtKB/Swiss-Prot for ELOA Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Gene Wiki entry for ELOA Gene

Additional gene information for ELOA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOA Gene

Genomics for ELOA Gene

GeneHancer (GH) Regulatory Elements for ELOA Gene

Promoters and enhancers for ELOA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I023742 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.8 +1.0 991 3.4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ELOA SRSF10 SRRM1 LINC01355 FUCA1 KDM1A GC01P023754
GH01I023975 Promoter/Enhancer 2.9 UCNEbase EPDnew Ensembl ENCODE dbSUPER 42.1 +235.7 235682 6.4 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SRSF10 ELOA SRRM1 LINC01355 KDM1A RPL11 ZNF436-AS1 PNRC2 CNR2 RUNX3
GH01I023691 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30 -50.5 -50532 3.1 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 RPL11 SRSF10 SRRM1 LINC01355 PNRC2 HNRNPR KDM1A ELOA ASAP3 GC01M023708
GH01I023954 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19.9 +215.0 214987 7.5 MLX DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A ZNF610 PNRC2 SRSF10 ELOA KDM1A SRRM1 LINC01355 ZNF436 ENSG00000230228
GH01I023366 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.9 -373.7 -373685 6.6 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 ZNF436 ZNF436-AS1 ENSG00000201405 GC01P023371 KDM1A SRSF10 LINC01355 ELOA ZBTB40 RPL11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ELOA on UCSC Golden Path with GeneCards custom track

Genomic Locations for ELOA Gene

Genomic Locations for ELOA Gene
chr1:23,743,155-23,762,059
(GRCh38/hg38)
Size:
18,905 bases
Orientation:
Plus strand
chr1:24,069,645-24,088,549
(GRCh37/hg19)

Genomic View for ELOA Gene

Genes around ELOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOA Gene

Proteins for ELOA Gene

  • Protein details for ELOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14241-ELOA1_HUMAN
    Recommended name:
    Elongin-A
    Protein Accession:
    Q14241
    Secondary Accessions:
    • B2R7Q8
    • Q8IXH1

    Protein attributes for ELOA Gene

    Size:
    798 amino acids
    Molecular mass:
    89909 Da
    Quaternary structure:
    • Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit.
    SequenceCaution:
    • Sequence=AAA75492.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH02883.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO15305.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35905.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB40157.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW95070.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ELOA Gene

neXtProt entry for ELOA Gene

Post-translational modifications for ELOA Gene

No Post-translational modifications

Other Protein References for ELOA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELOA Gene

Domains & Families for ELOA Gene

Gene Families for ELOA Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ELOA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14241

UniProtKB/Swiss-Prot:

ELOA1_HUMAN :
  • The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
genes like me logo Genes that share domains with ELOA: view

Function for ELOA Gene

Molecular function for ELOA Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Phenotypes From GWAS Catalog for ELOA Gene

Gene Ontology (GO) - Molecular Function for ELOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ELOA: view
genes like me logo Genes that share phenotypes with ELOA: view

Animal Models for ELOA Gene

MGI Knock Outs for ELOA:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELOA Gene

Localization for ELOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ELOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA,IDA 22664934
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0070449 elongin complex IBA,IEA --
genes like me logo Genes that share ontologies with ELOA: view

Pathways & Interactions for ELOA Gene

genes like me logo Genes that share pathways with ELOA: view

Gene Ontology (GO) - Biological Process for ELOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,TAS --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with ELOA: view

No data available for SIGNOR curated interactions for ELOA Gene

Drugs & Compounds for ELOA Gene

No Compound Related Data Available

Transcripts for ELOA Gene

mRNA/cDNA for ELOA Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELOA Gene

No ASD Table

Relevant External Links for ELOA Gene

GeneLoc Exon Structure for
ELOA
ECgene alternative splicing isoforms for
ELOA

Expression for ELOA Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOA Gene:

ELOA

Evidence on tissue expression from TISSUES for ELOA Gene

  • Nervous system(4.5)
  • Lung(4.4)
  • Heart(4.3)
  • Stomach(2.1)
  • Muscle(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOA Gene

Orthologs for ELOA Gene

This gene was present in the common ancestor of animals.

Orthologs for ELOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB3 34 33
  • 99.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100851883 33
  • 86.83 (n)
TCEB3 34
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEB3 34 33
  • 86.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tceb3 33
  • 82.99 (n)
mouse
(Mus musculus)
Mammalia Tceb3 34 33
  • 82.7 (n)
OneToOne
Eloa 16
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves TCEB3 34 33
  • 64.68 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tceb3 33
  • 59.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13162 33
zebrafish
(Danio rerio)
Actinopterygii zgc:55573 33
  • 58.72 (n)
tceb3 34
  • 44 (a)
OneToMany
Dr.206 33
fruit fly
(Drosophila melanogaster)
Insecta EloA 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03D7.4 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
Species where no ortholog for ELOA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELOA Gene

ENSEMBL:
Gene Tree for ELOA (if available)
TreeFam:
Gene Tree for ELOA (if available)

Paralogs for ELOA Gene

Paralogs for ELOA Gene

Pseudogenes.org Pseudogenes for ELOA Gene

genes like me logo Genes that share paralogs with ELOA: view

Variants for ELOA Gene

Sequence variations from dbSNP and Humsavar for ELOA Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000100294 -- 23,758,196(+) T/C intron_variant
rs1000147560 -- 23,745,512(+) A/ intron_variant
rs1000211 -- 23,760,694(+) C/T 3_prime_UTR_variant
rs1000212 -- 23,760,668(+) G/A 3_prime_UTR_variant
rs1000213 -- 23,760,530(+) T/G 3_prime_UTR_variant

Variation tolerance for ELOA Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELOA Gene

Human Gene Mutation Database (HGMD)
ELOA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ELOA Gene

Disorders for ELOA Gene

Additional Disease Information for ELOA

No disorders were found for ELOA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOA Gene

Publications for ELOA Gene

  1. A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. (PMID: 8654961) Aso T … Conaway RC (Gene 1996) 3 4 22 58
  2. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PMID: 7660129) Aso T … Conaway RC (Science (New York, N.Y.) 1995) 2 3 22 58
  3. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. (PMID: 19037258) Yasukawa T … Aso T (The EMBO journal 2008) 3 22 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ELOA Gene

Sources for ELOA Gene

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