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Aliases for ELOA Gene

Aliases for ELOA Gene

  • Elongin A 2 3
  • Transcription Elongation Factor B Subunit 3 2 3 5
  • TCEB3 3 4 5
  • Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit A1 3 4
  • Elongin 110 KDa Subunit 3 4
  • SIII P110 3 4
  • Transcription Elongation Factor B Alpha Subunit 3
  • Transcription Elongation Factor B Polypeptide 3 3
  • Elongin-A 4
  • TCEB3A 3
  • SIII 3
  • EloA 4

External Ids for ELOA Gene

Previous HGNC Symbols for ELOA Gene

  • TCEB3

Summaries for ELOA Gene

Entrez Gene Summary for ELOA Gene

  • This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELOA Gene

ELOA (Elongin A) is a Protein Coding gene. Diseases associated with ELOA include Renal Cell Carcinoma, Papillary. Among its related pathways are HIV Life Cycle and Gene Expression. An important paralog of this gene is ELOA2.

UniProtKB/Swiss-Prot for ELOA Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Gene Wiki entry for ELOA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOA Gene

Genomics for ELOA Gene

Regulatory Elements for ELOA Gene

Enhancers for ELOA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F023975 2.2 ENCODE 17.4 +235.7 235682 6.4 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 RPL11 ELOA LINC01355 CNR2 PNRC2 SRSF10
GH01F024641 1.5 FANTOM5 ENCODE 25.4 +900.2 900249 4.1 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 RPL11 ELOA SYF2 ENSG00000261349 PNRC2 NCMAP RUNX3 SRRM1 GC01P024703
GH01F024414 1.2 ENCODE 27.3 +674.1 674116 5.3 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ZNF610 ELOA SYF2 STPG1 NIPAL3 RPL11 RCAN3 ENSG00000261349 NCMAP GC01P024477
GH01F023018 1.2 ENCODE 26 -723.2 -723231 3.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ELOA RPL11 CDC42-IT1 ZBTB40-IT1 LINC01355 LACTBL1 ENSG00000271428 PNRC2 HTR1D KDM1A
GH01F024316 1.2 ENCODE 25.4 +577.1 577063 7.7 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 RPL11 ELOA ZNF436-AS1 SYF2 ENSG00000261349 PNRC2 GRHL3 LOC105376871
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELOA on UCSC Golden Path with GeneCards custom track

Promoters for ELOA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075495 745 2601 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ELOA Gene

Chromosome:
1
Start:
23,743,155 bp from pter
End:
23,762,059 bp from pter
Size:
18,905 bases
Orientation:
Plus strand

Genomic View for ELOA Gene

Genes around ELOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOA Gene

Proteins for ELOA Gene

  • Protein details for ELOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14241-ELOA1_HUMAN
    Recommended name:
    Transcription elongation factor B polypeptide 3
    Protein Accession:
    Q14241
    Secondary Accessions:
    • B2R7Q8
    • Q8IXH1

    Protein attributes for ELOA Gene

    Size:
    798 amino acids
    Molecular mass:
    89909 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A (By similarity).
    SequenceCaution:
    • Sequence=AAA75492.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH02883.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO15305.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35905.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB40157.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW95070.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ELOA Gene

neXtProt entry for ELOA Gene

Post-translational modifications for ELOA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELOA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELOA Gene

Domains & Families for ELOA Gene

Suggested Antigen Peptide Sequences for ELOA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14241

UniProtKB/Swiss-Prot:

ELOA1_HUMAN :
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
  • Contains 1 F-box domain.
  • Contains 1 TFIIS N-terminal domain.
genes like me logo Genes that share domains with ELOA: view

No data available for Gene Families for ELOA Gene

Function for ELOA Gene

Molecular function for ELOA Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Gene Ontology (GO) - Molecular Function for ELOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ELOA: view
genes like me logo Genes that share phenotypes with ELOA: view

Animal Models for ELOA Gene

MGI Knock Outs for ELOA:

Animal Model Products

miRNA for ELOA Gene

miRTarBase miRNAs that target ELOA

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELOA Gene

Localization for ELOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ELOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016021 integral component of membrane IEA --
GO:0070449 elongin complex IBA --
genes like me logo Genes that share ontologies with ELOA: view

Pathways & Interactions for ELOA Gene

genes like me logo Genes that share pathways with ELOA: view

Gene Ontology (GO) - Biological Process for ELOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 7660129
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with ELOA: view

No data available for SIGNOR curated interactions for ELOA Gene

Transcripts for ELOA Gene

mRNA/cDNA for ELOA Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ELOA Gene

Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELOA Gene

No ASD Table

Relevant External Links for ELOA Gene

GeneLoc Exon Structure for
ELOA
ECgene alternative splicing isoforms for
ELOA

Expression for ELOA Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOA Gene:

ELOA

SOURCE GeneReport for Unigene cluster for ELOA Gene:

Hs.15535
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ELOA Gene

Orthologs for ELOA Gene

This gene was present in the common ancestor of animals.

Orthologs for ELOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB3 34 35
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia LOC100851883 34
  • 86.83 (n)
TCEB3 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEB3 34 35
  • 86.76 (n)
rat
(Rattus norvegicus)
Mammalia Tceb3 34
  • 82.99 (n)
mouse
(Mus musculus)
Mammalia Tceb3 34 16 35
  • 82.7 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves TCEB3 34 35
  • 64.68 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tceb3 34
  • 59.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13162 34
zebrafish
(Danio rerio)
Actinopterygii zgc:55573 34
  • 58.72 (n)
tceb3 35
  • 44 (a)
OneToMany
Dr.206 34
fruit fly
(Drosophila melanogaster)
Insecta EloA 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03D7.4 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for ELOA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELOA Gene

ENSEMBL:
Gene Tree for ELOA (if available)
TreeFam:
Gene Tree for ELOA (if available)

Paralogs for ELOA Gene

Paralogs for ELOA Gene

Pseudogenes.org Pseudogenes for ELOA Gene

genes like me logo Genes that share paralogs with ELOA: view

Variants for ELOA Gene

Sequence variations from dbSNP and Humsavar for ELOA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000211 -- 23,760,694(-) CTTCA(A/G)CAGCA nc-transcript-variant, utr-variant-3-prime
rs1000212 -- 23,760,668(-) GCCAA(C/T)AGTTG nc-transcript-variant, utr-variant-3-prime
rs1000213 -- 23,760,530(-) GCTGG(A/C)TTTTA nc-transcript-variant, utr-variant-3-prime
rs1045017 -- 23,761,638(-) CCTGA(C/T)TCTTC intron-variant, utr-variant-3-prime
rs10917421 -- 23,755,040(+) taagt(A/G)atcct intron-variant

Variation tolerance for ELOA Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELOA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ELOA Gene

Disorders for ELOA Gene

MalaCards: The human disease database

(1) MalaCards diseases for ELOA Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary
  • renal cell carcinoma, papillary, 1
- elite association - COSMIC cancer census association via MalaCards
Search ELOA in MalaCards View complete list of genes associated with diseases

Relevant External Links for ELOA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA
genes like me logo Genes that share disorders with ELOA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELOA Gene

Publications for ELOA Gene

  1. A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. (PMID: 8654961) Aso T. … Conaway R.C. (Gene 1996) 3 4 22 64
  2. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PMID: 7660129) Aso T. … Conaway R.C. (Science 1995) 2 3 22 64
  3. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. (PMID: 19037258) Yasukawa T. … Aso T. (EMBO J. 2008) 3 22 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ELOA Gene

Sources for ELOA Gene

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