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Aliases for ELMSAN1 Gene

Aliases for ELMSAN1 Gene

  • ELM2 And Myb/SANT Domain Containing 1 2 3
  • ELM2 And Myb/SANT-Like Domain Containing 1 3 5
  • C14orf117 3 4
  • C14orf43 3 4
  • MIDEAS 3 4
  • Chromosome 14 Open Reading Frame 117 2
  • Chromosome 14 Open Reading Frame 43 2
  • C14_5541 3
  • LSR68 3

External Ids for ELMSAN1 Gene

Previous HGNC Symbols for ELMSAN1 Gene

  • C14orf117
  • C14orf43

Previous GeneCards Identifiers for ELMSAN1 Gene

  • GC14M074184

Summaries for ELMSAN1 Gene

GeneCards Summary for ELMSAN1 Gene

ELMSAN1 (ELM2 And Myb/SANT Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is ZNF541.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELMSAN1 Gene

Genomics for ELMSAN1 Gene

Regulatory Elements for ELMSAN1 Gene

Enhancers for ELMSAN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELMSAN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELMSAN1 Gene

Chromosome:
14
Start:
73,715,122 bp from pter
End:
73,790,285 bp from pter
Size:
75,164 bases
Orientation:
Minus strand

Genomic View for ELMSAN1 Gene

Genes around ELMSAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELMSAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELMSAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELMSAN1 Gene

Proteins for ELMSAN1 Gene

  • Protein details for ELMSAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJG2-EMSA1_HUMAN
    Recommended name:
    ELM2 and SANT domain-containing protein 1
    Protein Accession:
    Q6PJG2
    Secondary Accessions:
    • Q6PK13
    • Q6PK59
    • Q6ZS23

    Protein attributes for ELMSAN1 Gene

    Size:
    1045 amino acids
    Molecular mass:
    114989 Da
    Quaternary structure:
    • Interacts with DNTTIP1 (PubMed:21573134, PubMed:25653165). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain (PubMed:25653165).
    SequenceCaution:
    • Sequence=AAH06511.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ELMSAN1 Gene

Proteomics data for ELMSAN1 Gene at MOPED

Post-translational modifications for ELMSAN1 Gene

  • Ubiquitination at Lys 843
  • Modification sites at PhosphoSitePlus

Other Protein References for ELMSAN1 Gene

No data available for DME Specific Peptides for ELMSAN1 Gene

Domains & Families for ELMSAN1 Gene

Gene Families for ELMSAN1 Gene

Protein Domains for ELMSAN1 Gene

Suggested Antigen Peptide Sequences for ELMSAN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PJG2

UniProtKB/Swiss-Prot:

EMSA1_HUMAN :
  • Contains 1 ELM2 domain.
Domain:
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
genes like me logo Genes that share domains with ELMSAN1: view

Function for ELMSAN1 Gene

Gene Ontology (GO) - Molecular Function for ELMSAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ELMSAN1: view
genes like me logo Genes that share phenotypes with ELMSAN1: view

Animal Model Products

miRNA for ELMSAN1 Gene

miRTarBase miRNAs that target ELMSAN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELMSAN1 Gene

Localization for ELMSAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELMSAN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELMSAN1 Gene COMPARTMENTS Subcellular localization image for ELMSAN1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ELMSAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with ELMSAN1: view

Pathways & Interactions for ELMSAN1 Gene

SuperPathways for ELMSAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELMSAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ELMSAN1: view

No data available for Pathways by source and SIGNOR curated interactions for ELMSAN1 Gene

Drugs & Compounds for ELMSAN1 Gene

No Compound Related Data Available

Transcripts for ELMSAN1 Gene

Unigene Clusters for ELMSAN1 Gene

ELM2 and Myb/SANT-like domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELMSAN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for ELMSAN1 Gene

GeneLoc Exon Structure for
ELMSAN1
ECgene alternative splicing isoforms for
ELMSAN1

Expression for ELMSAN1 Gene

mRNA expression in normal human tissues for ELMSAN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELMSAN1 Gene

This gene is overexpressed in Pancreatic juice (16.2), Peripheral blood mononuclear cells (13.8), Lung (13.2), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELMSAN1 Gene



SOURCE GeneReport for Unigene cluster for ELMSAN1 Gene Hs.594157

genes like me logo Genes that share expression patterns with ELMSAN1: view

Protein tissue co-expression partners for ELMSAN1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ELMSAN1 Gene

Orthologs for ELMSAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELMSAN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELMSAN1 35
  • 89.66 (n)
  • 90.43 (a)
ELMSAN1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELMSAN1 35
  • 89.71 (n)
  • 92.48 (a)
ELMSAN1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elmsan1 35
  • 85.53 (n)
  • 86.34 (a)
Elmsan1 16
Elmsan1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELMSAN1 35
  • 99.55 (n)
  • 99.71 (a)
C14ORF43 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elmsan1 35
  • 84.46 (n)
  • 84.98 (a)
oppossum
(Monodelphis domestica)
Mammalia ELMSAN1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF43 35
  • 60.74 (n)
  • 60.12 (a)
ELMSAN1 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELMSAN1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elmsan1 35
  • 56.33 (n)
  • 51.31 (a)
zebrafish
(Danio rerio)
Actinopterygii ELMSAN1 (1 of 2) 36
  • 30 (a)
OneToMany
ELMSAN1 (2 of 2) 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16779 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea saeg-1 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for ELMSAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELMSAN1 Gene

ENSEMBL:
Gene Tree for ELMSAN1 (if available)
TreeFam:
Gene Tree for ELMSAN1 (if available)

Paralogs for ELMSAN1 Gene

Paralogs for ELMSAN1 Gene

(2) SIMAP similar genes for ELMSAN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ELMSAN1: view

Variants for ELMSAN1 Gene

Sequence variations from dbSNP and Humsavar for ELMSAN1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_050182 -
VAR_050183 -
rs35905570 - 73,722,739(+) CTCAT(C/T)GCTCG reference, missense
rs42975 -- 73,779,868(-) cgggc(A/G)cggtg intron-variant
rs42976 -- 73,779,834(-) tttgg(A/G)aggcc intron-variant

Variation tolerance for ELMSAN1 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.32; 76.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ELMSAN1 Gene

Disorders for ELMSAN1 Gene

Relevant External Links for ELMSAN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELMSAN1

No disorders were found for ELMSAN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELMSAN1 Gene

Publications for ELMSAN1 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3

Products for ELMSAN1 Gene

Sources for ELMSAN1 Gene

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