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Aliases for ELMOD1 Gene

Aliases for ELMOD1 Gene

  • ELMO Domain Containing 1 2 3
  • ELMO/CED-12 Domain Containing 1 2 5

External Ids for ELMOD1 Gene

Previous GeneCards Identifiers for ELMOD1 Gene

  • GC11P106968
  • GC11P107463
  • GC11P103387
  • GC11P107464

Summaries for ELMOD1 Gene

GeneCards Summary for ELMOD1 Gene

ELMOD1 (ELMO Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ELMOD2.

UniProtKB/Swiss-Prot for ELMOD1 Gene

  • Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELMOD1 Gene

Genomics for ELMOD1 Gene

Regulatory Elements for ELMOD1 Gene

Enhancers for ELMOD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELMOD1 on UCSC Golden Path with GeneCards custom track

Promoters for ELMOD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ELMOD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELMOD1 Gene

107,591,091 bp from pter
107,666,779 bp from pter
75,689 bases
Plus strand

Genomic View for ELMOD1 Gene

Genes around ELMOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELMOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELMOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELMOD1 Gene

Proteins for ELMOD1 Gene

  • Protein details for ELMOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ELMO domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4E167
    • G5E9S5
    • Q9NPW3

    Protein attributes for ELMOD1 Gene

    334 amino acids
    Molecular mass:
    39052 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ELMOD1 Gene


neXtProt entry for ELMOD1 Gene

Proteomics data for ELMOD1 Gene at MOPED

Post-translational modifications for ELMOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELMOD1 Gene

No data available for DME Specific Peptides for ELMOD1 Gene

Domains & Families for ELMOD1 Gene

Protein Domains for ELMOD1 Gene


Suggested Antigen Peptide Sequences for ELMOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ELMO domain.
  • Contains 1 ELMO domain.
genes like me logo Genes that share domains with ELMOD1: view

No data available for Gene Families for ELMOD1 Gene

Function for ELMOD1 Gene

Molecular function for ELMOD1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.
genes like me logo Genes that share phenotypes with ELMOD1: view

Animal Models for ELMOD1 Gene

MGI Knock Outs for ELMOD1:

Animal Model Products

miRNA for ELMOD1 Gene

miRTarBase miRNAs that target ELMOD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELMOD1 Gene

Localization for ELMOD1 Gene

Subcellular locations from

Jensen Localization Image for ELMOD1 Gene COMPARTMENTS Subcellular localization image for ELMOD1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ELMOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ELMOD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ELMOD1 Gene

Pathways & Interactions for ELMOD1 Gene

SuperPathways for ELMOD1 Gene

No Data Available

Interacting Proteins for ELMOD1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q8N336-ELMD1_HUMAN ENSP00000265840 for ELMOD1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ELMOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ELMOD1: view

No data available for Pathways by source and SIGNOR curated interactions for ELMOD1 Gene

Drugs & Compounds for ELMOD1 Gene

No Compound Related Data Available

Transcripts for ELMOD1 Gene

mRNA/cDNA for ELMOD1 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ELMOD1 Gene

ELMO/CED-12 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELMOD1 Gene

No ASD Table

Relevant External Links for ELMOD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ELMOD1 Gene

mRNA expression in normal human tissues for ELMOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELMOD1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Frontal Cortex (BA9) (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Putamen (basal ganglia) (x4.9), and Brain - Caudate (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for ELMOD1 Gene

This gene is overexpressed in Platelet (50.2) and Retina (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ELMOD1 Gene

SOURCE GeneReport for Unigene cluster for ELMOD1 Gene Hs.495779

genes like me logo Genes that share expression patterns with ELMOD1: view

Protein tissue co-expression partners for ELMOD1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ELMOD1 Gene

Orthologs for ELMOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELMOD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ELMOD1 35
  • 92.13 (n)
  • 98.47 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ELMOD1 35
  • 92.02 (n)
  • 97.6 (a)
  • 98 (a)
(Mus musculus)
Mammalia Elmod1 35
  • 87.73 (n)
  • 96.32 (a)
Elmod1 16
Elmod1 36
  • 96 (a)
(Pan troglodytes)
Mammalia ELMOD1 35
  • 99.39 (n)
  • 99.7 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Elmod1 35
  • 88.52 (n)
  • 96.71 (a)
(Monodelphis domestica)
Mammalia ELMOD1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ELMOD1 36
  • 90 (a)
(Gallus gallus)
Aves ELMOD1 35
  • 82.83 (n)
  • 88.02 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia ELMOD1 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia elmod1 35
  • 75.35 (n)
  • 79.34 (a)
(Danio rerio)
Actinopterygii elmod1 35
  • 67.78 (n)
  • 73.21 (a)
elmod1 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10068 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
-- 36
  • 46 (a)
Species with no ortholog for ELMOD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELMOD1 Gene

Gene Tree for ELMOD1 (if available)
Gene Tree for ELMOD1 (if available)

Paralogs for ELMOD1 Gene

Paralogs for ELMOD1 Gene

(1) SIMAP similar genes for ELMOD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ELMOD1: view

Variants for ELMOD1 Gene

Sequence variations from dbSNP and Humsavar for ELMOD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs524611 -- 107,660,594(+) ATTGC(C/T)GTGGT intron-variant
rs525584 -- 107,660,706(+) AGATG(C/G)AGATG intron-variant
rs526626 -- 107,657,946(-) cttct(A/G)tatat intron-variant
rs527296 -- 107,657,759(-) CTAGA(C/T)CCCAT intron-variant
rs531097 -- 107,608,752(+) GAGAG(G/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELMOD1 Gene

Variant ID Type Subtype PubMed ID
esv2422201 CNV Duplication 17116639
nsv476 CNV Insertion 18451855

Variation tolerance for ELMOD1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ELMOD1 Gene

Disorders for ELMOD1 Gene

Relevant External Links for ELMOD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ELMOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELMOD1 Gene

Publications for ELMOD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Characterization of recombinant ELMOD (cell engulfment and motility domain) proteins as GTPase-activating proteins (GAPs) for ARF family GTPases. (PMID: 24616099) Ivanova A.A. … Kahn R.A. (J. Biol. Chem. 2014) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3

Products for ELMOD1 Gene

Sources for ELMOD1 Gene