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Aliases for ELMO3 Gene

Aliases for ELMO3 Gene

  • Engulfment And Cell Motility 3 2 3
  • Engulfment And Cell Motility 3 (Ced-12 Homolog, C. Elegans) 2
  • Engulfment And Cell Motility Protein 3 3
  • Ced-12 Homolog 3 3
  • CED-12 3
  • ELMO-3 3
  • CED12 3

External Ids for ELMO3 Gene

Summaries for ELMO3 Gene

Entrez Gene Summary for ELMO3 Gene

  • The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELMO3 Gene

ELMO3 (Engulfment And Cell Motility 3) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and SH3 domain binding. An important paralog of this gene is ELMO1.

UniProtKB/Swiss-Prot for ELMO3 Gene

  • Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELMO3 Gene

Genomics for ELMO3 Gene

Genomic Location for ELMO3 Gene

Start:
67,199,111 bp from pter
End:
67,204,029 bp from pter
Size:
4,919 bases
Orientation:
Plus strand

Genomic View for ELMO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELMO3 Gene

Regulatory Elements for ELMO3 Gene

Proteins for ELMO3 Gene

  • Protein details for ELMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BJ8-ELMO3_HUMAN
    Recommended name:
    Engulfment and cell motility protein 3
    Protein Accession:
    Q96BJ8
    Secondary Accessions:
    • B4DV86
    • Q9H8A5

    Protein attributes for ELMO3 Gene

    Size:
    720 amino acids
    Molecular mass:
    81467 Da
    Quaternary structure:
    • Probably interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1 (By similarity).

    Alternative splice isoforms for ELMO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELMO3 Gene

Proteomics data for ELMO3 Gene at MOPED

Post-translational modifications for ELMO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELMO3 Gene

No data available for DME Specific Peptides for ELMO3 Gene

Domains for ELMO3 Gene

Gene Families for ELMO3 Gene

HGNC:
  • ELMO :Engulfment and cell motility proteins

Protein Domains for ELMO3 Gene

UniProtKB/Swiss-Prot:

ELMO3_HUMAN
Domain:
  • Contains 1 ELMO domain.:
    • Q96BJ8
  • Contains 1 PH domain.:
    • Q96BJ8
genes like me logo Genes that share domains with ELMO3: view

Function for ELMO3 Gene

Molecular function for ELMO3 Gene

UniProtKB/Swiss-Prot Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).

Gene Ontology (GO) - Molecular Function for ELMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with ELMO3: view

Phenotypes for ELMO3 Gene

genes like me logo Genes that share phenotypes with ELMO3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ELMO3 Gene

Localization for ELMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELMO3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELMO3 Gene COMPARTMENTS Subcellular localization image for ELMO3 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ELMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ELMO3: view

Pathways for ELMO3 Gene

SuperPathways for ELMO3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with ELMO3: view

No data available for Pathways by source for ELMO3 Gene

Compounds for ELMO3 Gene

(3) HMDB Compounds for ELMO3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ELMO3: view

Transcripts for ELMO3 Gene

Unigene Clusters for ELMO3 Gene

Engulfment and cell motility 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELMO3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^
SP1: - - -
SP2: -
SP3: -
SP4: - - - -
SP5: - -
SP6: - -
SP7: - - - -
SP8:
SP9:
SP10:

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -

Relevant External Links for ELMO3 Gene

GeneLoc Exon Structure for
ELMO3
ECgene alternative splicing isoforms for
ELMO3

Expression for ELMO3 Gene

mRNA expression in normal human tissues for ELMO3 Gene

mRNA differential expression in normal tissues according to GTEx for ELMO3 Gene

This gene is overexpressed in Pancreas (4.7) and Colon - Transverse (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELMO3 Gene

SOURCE GeneReport for Unigene cluster for ELMO3 Gene Hs.377416

genes like me logo Genes that share expressions with ELMO3: view

Orthologs for ELMO3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELMO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELMO3 36
  • 99.35 (n)
  • 99.22 (a)
ELMO3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELMO3 36
  • 89.76 (n)
  • 92.93 (a)
ELMO3 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELMO3 36
  • 86.39 (n)
  • 89.08 (a)
ELMO3 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elmo3 36
  • 86.16 (n)
  • 90.83 (a)
Elmo3 16
Elmo3 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELMO3 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELMO3 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elmo3 36
  • 85.74 (n)
  • 90.69 (a)
chicken
(Gallus gallus)
Aves ELMO3 36
  • 72.11 (n)
  • 69.6 (a)
ELMO3 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELMO3 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elmo3 36
  • 61.29 (n)
  • 60.87 (a)
zebrafish
(Danio rerio)
Actinopterygii ELMO3 37
  • 63 (a)
OneToOne
im:7143453 36
  • 67.31 (n)
  • 67.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ced-12 37
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-12 37
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
Species with no ortholog for ELMO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELMO3 Gene

ENSEMBL:
Gene Tree for ELMO3 (if available)
TreeFam:
Gene Tree for ELMO3 (if available)

Paralogs for ELMO3 Gene

Paralogs for ELMO3 Gene

Selected SIMAP similar genes for ELMO3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ELMO3: view

Variants for ELMO3 Gene

Sequence variations from dbSNP and Humsavar for ELMO3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3837763 -- 67,199,456(-) GGGGG(-/G)GCTAC intron-variant
rs8058614 -- 67,199,794(+) CTTCC(A/G)ACCCC intron-variant
rs8058861 - 67,200,231(+) AGAGT(A/G)ACAGT reference, missense
rs8059662 -- 67,200,376(+) GGGAT(A/G)TGTGG intron-variant
rs33948247 - 67,201,769(+) TCCTA(C/T)GCCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ELMO3 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680
nsv524492 CNV Loss 19592680
nsv471092 CNV Gain 18288195
nsv457513 CNV Loss 19166990
dgv2889n71 CNV Loss 21882294

Relevant External Links for ELMO3 Gene

HapMap Linkage Disequilibrium report
ELMO3

Disorders for ELMO3 Gene

Relevant External Links for ELMO3

Genetic Association Database (GAD)
ELMO3
genes like me logo Genes that share disorders with ELMO3: view

No data available for UniProtKB/Swiss-Prot for ELMO3 Gene

Publications for ELMO3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. (PMID: 11595183) Gumienny T.L. … Ravichandran K.S. (Cell 2001) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ELMO3 Gene

Sources for ELMO3 Gene

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