Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ELMO2 Gene

Aliases for ELMO2 Gene

  • Engulfment And Cell Motility 2 2 3 5
  • Protein Ced-12 Homolog A 3 4
  • Engulfment And Cell Motility 2 (Ced-12 Homolog, C. Elegans) 2
  • PH Domain Protein CED12A 3
  • Ced-12 Homolog 2 3
  • KIAA1834 4
  • HCed-12A 4
  • Ced-12A 3
  • CED-12 3
  • ELMO-2 3
  • CED12A 4
  • CED12 3

External Ids for ELMO2 Gene

Previous GeneCards Identifiers for ELMO2 Gene

  • GC20M044723
  • GC20M045633
  • GC20M045680
  • GC20M044428
  • GC20M044994
  • GC20M041735

Summaries for ELMO2 Gene

Entrez Gene Summary for ELMO2 Gene

  • The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for ELMO2 Gene

ELMO2 (Engulfment And Cell Motility 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include binding and receptor tyrosine kinase binding. An important paralog of this gene is ELMO1.

UniProtKB/Swiss-Prot for ELMO2 Gene

  • Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Gene Wiki entry for ELMO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELMO2 Gene

Genomics for ELMO2 Gene

Regulatory Elements for ELMO2 Gene

Genomic Location for ELMO2 Gene

Chromosome:
20
Start:
46,366,049 bp from pter
End:
46,432,985 bp from pter
Size:
66,937 bases
Orientation:
Minus strand

Genomic View for ELMO2 Gene

Genes around ELMO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELMO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELMO2 Gene

Proteins for ELMO2 Gene

  • Protein details for ELMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JJ3-ELMO2_HUMAN
    Recommended name:
    Engulfment and cell motility protein 2
    Protein Accession:
    Q96JJ3
    Secondary Accessions:
    • E1P5T3
    • Q5JVZ6
    • Q7Z5G9
    • Q96CJ2
    • Q96ME5
    • Q96PA9
    • Q9H938
    • Q9H9L5
    • Q9HAH0
    • Q9NQQ6

    Protein attributes for ELMO2 Gene

    Size:
    720 amino acids
    Molecular mass:
    82615 Da
    Quaternary structure:
    • Interacts with the SH3-domain of DOCK1 via its SH3-binding site. Probably part of a complex with DOCK1 and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2 (PubMed:20679435). Interacts with ADGRB3 (PubMed:24567399).
    SequenceCaution:
    • Sequence=BAB13879.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14210.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14405.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB47463.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ELMO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELMO2 Gene

Proteomics data for ELMO2 Gene at MOPED

Post-translational modifications for ELMO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ELMO2 Gene

Domains & Families for ELMO2 Gene

Gene Families for ELMO2 Gene

Protein Domains for ELMO2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JJ3

UniProtKB/Swiss-Prot:

ELMO2_HUMAN :
  • Contains 1 ELMO domain.
Domain:
  • Contains 1 ELMO domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with ELMO2: view

Function for ELMO2 Gene

Molecular function for ELMO2 Gene

UniProtKB/Swiss-Prot Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
genes like me logo Genes that share phenotypes with ELMO2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELMO2 Gene

Localization for ELMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELMO2 Gene

Cytoplasm. Cytoplasm, cytosol. Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELMO2 Gene COMPARTMENTS Subcellular localization image for ELMO2 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ELMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 20679435
genes like me logo Genes that share ontologies with ELMO2: view

Pathways & Interactions for ELMO2 Gene

genes like me logo Genes that share pathways with ELMO2: view

Pathways by source for ELMO2 Gene

Gene Ontology (GO) - Biological Process for ELMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0045087 innate immune response TAS --
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS --
GO:0060326 cell chemotaxis IMP 20679435
genes like me logo Genes that share ontologies with ELMO2: view

No data available for SIGNOR curated interactions for ELMO2 Gene

Drugs & Compounds for ELMO2 Gene

(3) Drugs for ELMO2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ELMO2: view

Transcripts for ELMO2 Gene

Unigene Clusters for ELMO2 Gene

Engulfment and cell motility 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELMO2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - -
SP14: - -
SP15: - -
SP16: - - - - - - -
SP17: - - -
SP18: - - - - - - -
SP19: - - - -
SP20:
SP21:
SP22:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1: - - -
SP2: - - -
SP3: - - -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for ELMO2 Gene

GeneLoc Exon Structure for
ELMO2
ECgene alternative splicing isoforms for
ELMO2

Expression for ELMO2 Gene

mRNA expression in normal human tissues for ELMO2 Gene

Protein differential expression in normal tissues from HIPED for ELMO2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3), Breast (11.2), and Monocytes (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELMO2 Gene



SOURCE GeneReport for Unigene cluster for ELMO2 Gene Hs.210469

mRNA Expression by UniProt/SwissProt for ELMO2 Gene

Q96JJ3-ELMO2_HUMAN
Tissue specificity: Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
genes like me logo Genes that share expression patterns with ELMO2: view

Protein tissue co-expression partners for ELMO2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ELMO2 Gene

Orthologs for ELMO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ELMO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELMO2 36
  • 100 (a)
OneToOne
ELMO2 35
  • 99.68 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ELMO2 35
  • 91.99 (n)
  • 99.31 (a)
ELMO2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELMO2 36
  • 99 (a)
OneToOne
ELMO2 35
  • 93.52 (n)
  • 99.44 (a)
mouse
(Mus musculus)
Mammalia Elmo2 16
Elmo2 36
  • 82 (a)
OneToOne
Elmo2 35
  • 89.4 (n)
  • 98.75 (a)
oppossum
(Monodelphis domestica)
Mammalia ELMO2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELMO2 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elmo2 35
  • 89.95 (n)
  • 98.61 (a)
chicken
(Gallus gallus)
Aves ELMO2 35
  • 83.7 (n)
  • 96.94 (a)
ELMO2 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELMO2 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68475 35
tropical clawed frog
(Silurana tropicalis)
Amphibia elmo1 35
  • 78.43 (n)
  • 89.31 (a)
zebrafish
(Danio rerio)
Actinopterygii ELMO2 36
  • 79 (a)
OneToOne
LOC100006857 35
  • 75.49 (n)
  • 82.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ced-12 37
  • 44 (a)
Ced-12 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-12 36
  • 19 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03264 35
  • 43.92 (n)
  • 26.9 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3186 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
Species with no ortholog for ELMO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELMO2 Gene

ENSEMBL:
Gene Tree for ELMO2 (if available)
TreeFam:
Gene Tree for ELMO2 (if available)

Paralogs for ELMO2 Gene

Paralogs for ELMO2 Gene

Pseudogenes.org Pseudogenes for ELMO2 Gene

genes like me logo Genes that share paralogs with ELMO2: view

Variants for ELMO2 Gene

Sequence variations from dbSNP and Humsavar for ELMO2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs34630674 - 46,367,438(-) CTGGA(G/T)AACAT reference, missense
rs2260851 -- 46,382,949(+) GGGTA(C/G)CCACA intron-variant
rs2260959 -- 46,380,090(+) ACAGA(A/G)GATCG intron-variant
rs2261051 -- 46,377,694(+) CTCCC(C/T)CTGAA intron-variant
rs2261138 -- 46,372,481(+) CAAAA(A/G)TTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELMO2 Gene

Variant ID Type Subtype PubMed ID
nsv820217 CNV Loss 19587683

Variation tolerance for ELMO2 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELMO2 Gene

HapMap Linkage Disequilibrium report
ELMO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELMO2 Gene

Disorders for ELMO2 Gene

Relevant External Links for ELMO2

Genetic Association Database (GAD)
ELMO2
Human Genome Epidemiology (HuGE) Navigator
ELMO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELMO2

No disorders were found for ELMO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELMO2 Gene

Publications for ELMO2 Gene

  1. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. (PMID: 11595183) Gumienny T.L. … Ravichandran K.S. (Cell 2001) 2 3 4 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion. (PMID: 25332238) Abu-Thuraia A. … CA'tAc J.F. (Mol. Cell. Biol. 2015) 3

Products for ELMO2 Gene

Sources for ELMO2 Gene

Back to Top

Content