Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ELMO2 Gene

protein-coding   GIFtS: 57
GCID: GC20M044994

Engulfment And Cell Motility 2

(Previous names: engulfment and cell motility 2 (ced-12 homolog, C. elegans))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Engulfment And Cell Motility 21 2     ELMO-22
Protein Ced-12 Homolog A2 3     Ced-12 Homolog 22
hCed-12A2 3     Engulfment And Cell Motility Protein 22
CED122 5     PH Domain Protein CED12A2
Engulfment And Cell Motility 2 (Ced-12 Homolog, C. Elegans)1     CED12A3
CED-122     KIAA18343

External Ids:    HGNC: 172331   Entrez Gene: 639162   Ensembl: ENSG000000625987   OMIM: 6064215   UniProtKB: Q96JJ33   

Export aliases for ELMO2 gene to outside databases

Previous GC identifers: GC20M044723 GC20M045633 GC20M045680 GC20M044428 GC20M041735


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ELMO2 Gene:
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C.
elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration.
Alternative splicing results in multiple transcript variants encoding the same protein. (provided by RefSeq, Jul
2008)

GeneCards Summary for ELMO2 Gene:
ELMO2 (engulfment and cell motility 2) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and receptor tyrosine kinase binding. An important paralog of this gene is ELMO3.

UniProtKB/Swiss-Prot: ELMO2_HUMAN, Q96JJ3
Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.
Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate
Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1

Gene Wiki entry for ELMO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELMO2 gene promoter:
         HFH-3   FOXI1   Egr-3   Pax-3   HOXA5   STAT3   Cart-1   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ELMO2 promoter sequence
   Search Chromatin IP Primers for ELMO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELMO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13

ELMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELMO2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044994:  view genomic region     (about GC identifiers)

Start:
44,994,688 bp from pter      End:
45,061,704 bp from pter
Size:
67,017 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ELMO2_HUMAN, Q96JJ3 (See protein sequence)
Recommended Name: Engulfment and cell motility protein 2  
Size: 720 amino acids; 82615 Da
Subunit: Interacts with the SH3-domain of DOCK1 via its SH3-binding site. Probably part of a complex with DOCK1
and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2;
mediates activation of RAC1 by EPHA2
Sequence caution: Sequence=BAB13879.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14210.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14405.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB47463.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: E1P5T3 Q5JVZ6 Q96CJ2 Q96ME5 Q96PA9 Q9H938 Q9H9L5 Q9HAH0 Q9NQQ6

Explore the universe of human proteins at neXtProt for ELMO2: NX_Q96JJ3

Explore proteomics data for ELMO2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys532, Lys542
  • Modification sites at PhosphoSitePlus

  • See ELMO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_573403.1  NP_877496.1  

    ENSEMBL proteins: 
     ENSP00000290246   ENSP00000431972   ENSP00000361249   ENSP00000414329   ENSP00000326172  
     ENSP00000388962   ENSP00000416181   ENSP00000379673   ENSP00000396519   ENSP00000409920  
     ENSP00000415641  
    Reactome Protein details: Q96JJ3

    ELMO2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ELMO2
    OriGene Protein Over-expression Lysate for ELMO2
    OriGene MassSpec for ELMO2
    OriGene Custom Protein Services for ELMO2
    GenScript Custom Purified and Recombinant Proteins Services for ELMO2
    Novus Biologicals ELMO2 Proteins
    Novus Biologicals ELMO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ELMO2

     
    Search eBioscience for Proteins for ELMO2 

    ELMO2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ELMO2
    OriGene Custom Antibody Services for ELMO2
    Novus Biologicals ELMO2 Antibodies
    Abcam antibodies for ELMO2
    Cloud-Clone Corp. Antibodies for ELMO2
    ThermoFisher Antibodies for ELMO2
    LSBio Antibodies in human, mouse, rat for ELMO2

    ELMO2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ELMO2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELMO2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ELMO2
    Cloud-Clone Corp. CLIAs for ELMO2
    Search eBioscience for ELISAs for ELMO2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ELMO: Engulfment and cell motility proteins

    Selected InterPro protein domains (see all 6):
     IPR011989 ARM-like
     IPR001849 Pleckstrin_homology
     IPR006816 Engulfment_cell_motility_ELMO
     IPR011993 PH_like_dom
     IPR024574 DUF3361

    Graphical View of Domain Structure for InterPro Entry Q96JJ3

    ProtoNet protein and cluster: Q96JJ3

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: ELMO2_HUMAN, Q96JJ3
    Similarity: Contains 1 ELMO domain
    Similarity: Contains 1 PH domain


    Find genes that share domains with ELMO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELMO2_HUMAN, Q96JJ3
    Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.
    Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate
    Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0017124SH3 domain binding IEA--
    GO:0030971receptor tyrosine kinase binding IPI--
         
    Find genes that share ontologies with ELMO2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ELMO2:
     Elongated cells with protrusio 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELMO2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELMO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELMO2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELMO2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ELMO2:
    hsa-mir-17-5p (MIRT050992), hsa-mir-200a-3p (MIRT020346), hsa-mir-200c-3p (MIRT021068), hsa-mir-429 (MIRT016635), hsa-mir-141-3p (MIRT021653), hsa-mir-193b-3p (MIRT016514), hsa-mir-200b-3p (MIRT024122)

    Block miRNA regulation of human, mouse, rat ELMO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELMO2 (see all 38):
    hsa-miR-193a-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-29a hsa-miR-570 hsa-miR-4267 hsa-miR-1184 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidELMO2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ELMO2
    Predesigned siRNA for gene silencing in human, mouse, rat ELMO2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ELMO2

    Clone
    Products:
         
    OriGene clones in human, mouse for ELMO2 (see all 13)
    OriGene ORF clones in mouse, rat for ELMO2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELMO2 (NM_182764)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELMO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELMO2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ELMO2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ELMO2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELMO2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ELMO2_HUMAN, Q96JJ3: Cytoplasm. Cytoplasm, cytosol. Membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    cytoskeleton2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0016020membrane IDA--

    Find genes that share ontologies with ELMO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ELMO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77


    Find genes that share SuperPaths with ELMO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ELMO2
        Regulation of actin dynamics for phagocytic cup formation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELMO2
    Interactions:

        GeneGlobe Interaction Network for ELMO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ELMO2 (Q96JJ33 ENSP000002902464) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP2P425753, ENSP000003126644I2D: score=1 STRING: ENSP00000312664
    CRKP461083I2D: score=1 
    DOCK1Q141853I2D: score=1 
    JMJD6Q6NYC13I2D: score=1 
    ILKENSP000002994214STRING: ENSP00000299421
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis ----
    GO:0006915apoptotic process IEA--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--
    GO:0060326cell chemotaxis IMP--

    Find genes that share ontologies with ELMO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELMO2

    3 HMDB Compounds for ELMO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ELMO2 gene (3 alternative transcripts): 
    NM_133171.3  NM_182764.1  NM_022086.6  

    Unigene Cluster for ELMO2:

    Engulfment and cell motility 2
    Hs.210469  [show with all ESTs]
    Unigene Representative Sequence: BC000143
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000290246(uc010zxq.1 uc002xrs.1 uc002xrt.1 uc010zxr.1 uc010zxs.1)
    ENST00000467800(uc002xrv.1) ENST00000372176 ENST00000452857 ENST00000352077
    ENST00000464448 ENST00000425546(uc002xrw.3) ENST00000462491 ENST00000481852
    ENST00000488853 ENST00000450812 ENST00000480042 ENST00000469801 ENST00000460474
    ENST00000497412 ENST00000487583 ENST00000462593 ENST00000396391(uc002xru.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ELMO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELMO2 (see all 38):
    hsa-miR-193a-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-29a hsa-miR-570 hsa-miR-4267 hsa-miR-1184 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidELMO2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ELMO2
    Predesigned siRNA for gene silencing in human, mouse, rat ELMO2
    Clone
    Products:
         
    OriGene clones in human, mouse for ELMO2 (see all 13)
    OriGene ORF clones in mouse, rat for ELMO2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELMO2 (NM_182764)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELMO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELMO2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ELMO2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELMO2
      QuantiTect SYBR Green Assays in human, mouse, rat ELMO2
      QuantiFast Probe-based Assays in human, mouse, rat ELMO2

    Additional mRNA sequence: 

    AB058737.1 AF398886.1 AF417861.1 AK022731.1 AK023103.1 AK057032.1 AK293861.1 AK299318.1 
    AK302710.1 AL833406.1 AY947527.1 BC000143.4 BC021079.2 BX648819.1 

    Selected DOTS entries (see all 30):

    DT.447877  DT.100787992  DT.97845583  DT.97845582  DT.92432175  DT.120808691  DT.100787993  DT.75172406 
    DT.120808823  DT.100787995  DT.95187697  DT.120808723  DT.100787994  DT.120808709  DT.91641756  DT.97845585 
    DT.120808696  DT.120808715  DT.120808807  DT.120808736  DT.120808759  DT.92432177  DT.120808693  DT.120808742 

    Selected AceView cDNA sequences (see all 198):

    AI129014 NM_133171 D19816 AW338837 BQ010525 AA721439 AI192991 NM_182764 
    BE017955 AI087363 AK057032 AA132247 BM511613 BM465291 BX109089 BU076271 
    AA459863 AI917488 BG059569 BQ420431 BM457710 BU170833 AB058737 CD672032 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ELMO2 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^
    SP1:                                      -                       -     -                                                                                       
    SP2:                          -     -     -     -                 -     -                                                                                       
    SP3:                                      -                             -                                                                                       
    SP4:                          -           -     -                 -     -                                                                                       
    SP5:                          -           -                       -     -                                                                                       

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
    SP1:        -                                         -                             -               
    SP2:        -                                         -                             -               
    SP3:        -                                         -                             -               
    SP4:        -                                                                                       
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ELMO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ELMO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ELMO2 Expression
    About this image

    ELMO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELMO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.210469

    UniProtKB/Swiss-Prot: ELMO2_HUMAN, Q96JJ3
    Tissue specificity: Widely expressed, with a higher expression in skeletal muscle, kidney and placenta

        Custom PCR Arrays for ELMO2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ELMO2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELMO2
    QuantiTect SYBR Green Assays in human, mouse, rat ELMO2
    QuantiFast Probe-based Assays in human, mouse, rat ELMO2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELMO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ELMO2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elmo21 , 5 engulfment and cell motility 2, ced-12 homolog (C. more5
    engulfment and cell motility 21
    89.4(n)1
    98.75(a)1
      2 (85.53 cM)5
    1405791  NM_207706.11  NP_997589.11 
     1652880315 
    chicken
    (Gallus gallus)
    Aves ELMO21 engulfment and cell motility 2 83.7(n)
    96.94(a)
      419307  XM_004947208.1  XP_004947265.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELMO26
    engulfment and cell motility 2
    88(a)
    1 ↔ 1
    GL343820.1(175326-190348)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684752 hypothetical protein MGC68475 79.31(n)    BC060396.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000068571 engulfment and cell motility protein 2 75.49(n)
    82.54(a)
      100006857  NM_001200058.1  NP_001186987.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ced-123 site-specific DNA-methyltransferase
    (cytosine-specific)
    44(a)   33C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea ced-126
    Protein CED-12 (ced-12) mRNA, complete cds
    19(a)
    1 → many
    I(10222880-10227486) WBGene00000426


    ENSEMBL Gene Tree for ELMO2 (if available)
    TreeFam Gene Tree for ELMO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ELMO2 gene
    ELMO32  ELMO12  
    2 SIMAP similar genes for ELMO2 using alignment to 10 protein entries:     ELMO2_HUMAN (see all proteins):
    ELMO1    ELMO3

    Find genes that share paralogs with ELMO2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ELMO2
    PGOHUM00000246662


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ELMO2 (see all 819)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898206651,2
    --44995168(+) AGGGGA/GCTGCA 2 -- ut310--------
    rs1824008171,2
    --44995250(+) GTGACA/CTCACC 2 -- ut310--------
    rs1855261821,2
    --44995296(+) GCAGCA/GTTCCT 2 -- ut310--------
    rs1884271441,2
    --44995302(+) TTCCTA/GGAGAC 2 -- ut310--------
    rs1807933251,2
    --44995382(+) ATTTCC/TGTCTG 2 -- ut310--------
    rs1852135091,2
    --44995435(+) GACCAA/GAGATG 2 -- ut310--------
    rs1501620351,2
    --44995552(+) AGATAC/TAGGTA 2 -- ut310--------
    rs413071671,2
    C,F--44995596(+) CTGTCC/TTCTGC 2 -- ut314Minor allele frequency- T:0.09NA WA 124
    rs124805571,2
    C,H--44995660(+) GAGCAG/AGCTCA 2 -- ut314Minor allele frequency- A:0.00NS EA 404
    rs2001202951,2
    C--44995687(-) TAACAA/CCAGCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ELMO2 (44994688 - 45061704 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ELMO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820217CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELMO2
    DNA2.0 Custom Variant and Variant Library Synthesis for ELMO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606421    OMIM disorders: --


    Find genes that share disorders with ELMO2           About GenesLikeMe

    Genetic Association Database (GAD): ELMO2
    Human Genome Epidemiology (HuGE) Navigator: ELMO2 (1 document)

    Export disorders for ELMO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ELMO2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ELMO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. (PubMed id 11595183)1, 2, 3 Gumienny T.L....Ravichandran K.S. (Cell 2001)
    2. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PubMed id 18602983)1, 4 Bento J.L....Mychaleckyj J.C. (Genomics 2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    6. The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. (PubMed id 11703939)1, 2 Zhou Z.... Horvitz H.R. (Dev. Cell 2001)
    7. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    8. ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions. (PubMed id 23184944)1 Margaron Y....CA'tAc J.F. (J. Biol. Chem. 2013)
    9. Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways. (PubMed id 22568984)1 Ho E. and Dagnino L. (amp 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 63916 HGNC: 17233 AceView: ELMO2 Ensembl:ENSG00000062598 euGenes: HUgn63916
    ECgene: ELMO2 H-InvDB: ELMO2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1834

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ELMO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ELMO2 gene:
    Search GeneIP for patents involving ELMO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ELMO2   OriGene RNAi products in human, mouse, rat for ELMO2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ELMO2  
     OriGene MassSpec something-or-other for ELMO2   OriGene clones in human, mouse for ELMO2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ELMO2   OriGene Purified Protein for ELMO2  
     OriGene ORF clones in mouse, rat for ELMO2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ELMO2   OriGene Custom Protein Services for ELMO2  

     
     
     Block miRNA regulation of human, mouse, rat ELMO2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ELMO2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELMO2 Predesigned siRNA for gene silencing in human, mouse, rat ELMO2
     QuantiFast Probe-based Assays in human, mouse, rat ELMO2 QuantiTect SYBR Green Assays in human, mouse, rat ELMO2
     Custom PCR Arrays for ELMO2 Search Chromatin IP Primers for ELMO2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELMO2  GeneGlobe Interaction Network for ELMO2
     Regulatory tfbs in ELMO2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ELMO2 GenScript cDNA clones with any tag delivered in your preferred vector for ELMO2
     GenScript Custom Assay Services for ELMO2 GenScript Custom overexpressing Cell Line Services for ELMO2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ELMO2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ELMO2 antibodies
     ELMO2 proteins
     ELMO2 lysates
     Antibodies for ELMO2
     See all of Abcam's Antibodies, Kits and Proteins for ELMO2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ELMO2
     Antibodies for ELMO2
     ELISAs for ELMO2
     CLIAs for ELMO2



     Browse ESI BIO Cell Lines and PureStem Progenitors for ELMO2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELMO2
     SwitchGear 3'UTR luciferase reporter plasmids for ELMO2
     SwitchGear Promoter luciferase reporter plasmids for ELMO2
     ThermoFisher Antibodies for ELMO2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELMO2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELMO2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELMO2
     LSBio Antibodies in human, mouse, rat for ELMO2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ELMO2
      Search eBioscience for proteins for ELMO2
      Search eBioscience for elisas for ELMO2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ELMO2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4