Aliases for ELMO1 Gene
External Ids for ELMO1 Gene
Previous GeneCards Identifiers for ELMO1 Gene
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for ELMO1 Gene
ELMO1 (Engulfment And Cell Motility 1) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include binding and SH3 domain binding. An important paralog of this gene is ELMO3.
UniProtKB/Swiss-Prot for ELMO1 Gene
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.