Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ELL2 Gene

Aliases for ELL2 Gene

  • Elongation Factor, RNA Polymerase II, 2 2 3

External Ids for ELL2 Gene

Previous GeneCards Identifiers for ELL2 Gene

  • GC05M094480
  • GC05M095687
  • GC05M095251
  • GC05M095297
  • GC05M095294
  • GC05M095248
  • GC05M090411
  • GC05M095220

Summaries for ELL2 Gene

GeneCards Summary for ELL2 Gene

ELL2 (Elongation Factor, RNA Polymerase II, 2) is a Protein Coding gene. An important paralog of this gene is ELL3.

UniProtKB/Swiss-Prot for ELL2 Gene

  • Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELL2 Gene

Genomics for ELL2 Gene

Regulatory Elements for ELL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ELL2 Gene

Chromosome:
5
Start:
95,885,098 bp from pter
End:
95,962,071 bp from pter
Size:
76,974 bases
Orientation:
Minus strand

Genomic View for ELL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELL2 Gene

Proteins for ELL2 Gene

  • Protein details for ELL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00472-ELL2_HUMAN
    Recommended name:
    RNA polymerase II elongation factor ELL2
    Protein Accession:
    O00472
    Secondary Accessions:
    • B4DNK7

    Protein attributes for ELL2 Gene

    Size:
    640 amino acids
    Molecular mass:
    72324 Da
    Quaternary structure:
    • Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with AFF4; the interaction is direct and leads to stabilize ELL2 and prevent ELL2 ubiquitination. Interacts with EAF1 and EAF2.

    Three dimensional structures from OCA and Proteopedia for ELL2 Gene

    Alternative splice isoforms for ELL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELL2 Gene

Proteomics data for ELL2 Gene at MOPED

Post-translational modifications for ELL2 Gene

  • Ubiquitinated by SIAH1, leading to its degradation by the proteaseome. Interaction with AFF4 stabilizeS ELL2 and prevent ELL2 ubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELL2 Gene

Domains & Families for ELL2 Gene

Protein Domains for ELL2 Gene

Suggested Antigen Peptide Sequences for ELL2 Gene

Graphical View of Domain Structure for InterPro Entry

O00472

UniProtKB/Swiss-Prot:

ELL2_HUMAN :
  • Belongs to the ELL/occludin family.
Family:
  • Belongs to the ELL/occludin family.
genes like me logo Genes that share domains with ELL2: view

No data available for Gene Families for ELL2 Gene

Function for ELL2 Gene

Molecular function for ELL2 Gene

UniProtKB/Swiss-Prot Function:
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.
genes like me logo Genes that share phenotypes with ELL2: view

Animal Model Products

miRNA for ELL2 Gene

miRTarBase miRNAs that target ELL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ELL2 Gene

Localization for ELL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELL2 Gene COMPARTMENTS Subcellular localization image for ELL2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0008023 transcription elongation factor complex IDA 22195968
genes like me logo Genes that share ontologies with ELL2: view

Pathways & Interactions for ELL2 Gene

SuperPathways for ELL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006368 transcription elongation from RNA polymerase II promoter IEA --
GO:0042795 snRNA transcription from RNA polymerase II promoter IMP 22195968
genes like me logo Genes that share ontologies with ELL2: view

No data available for Pathways by source and SIGNOR curated interactions for ELL2 Gene

Drugs & Compounds for ELL2 Gene

No Compound Related Data Available

Transcripts for ELL2 Gene

Unigene Clusters for ELL2 Gene

Elongation factor, RNA polymerase II, 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELL2 Gene

No ASD Table

Relevant External Links for ELL2 Gene

GeneLoc Exon Structure for
ELL2
ECgene alternative splicing isoforms for
ELL2

Expression for ELL2 Gene

mRNA expression in normal human tissues for ELL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELL2 Gene

This gene is overexpressed in Breast (30.8), Pancreas (20.8), Plasma (8.7), and Prostate (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELL2 Gene



SOURCE GeneReport for Unigene cluster for ELL2 Gene Hs.192221

genes like me logo Genes that share expression patterns with ELL2: view

Protein tissue co-expression partners for ELL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ELL2 Gene

Orthologs for ELL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELL2 35
  • 91.22 (n)
  • 93.33 (a)
ELL2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELL2 35
  • 92.96 (n)
  • 94.52 (a)
ELL2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ell2 35
  • 89.85 (n)
  • 90.89 (a)
Ell2 16
Ell2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELL2 35
  • 99.74 (n)
  • 99.69 (a)
ELL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ell2 35
  • 89.06 (n)
  • 90.11 (a)
oppossum
(Monodelphis domestica)
Mammalia ELL2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELL2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELL2 35
  • 73.7 (n)
  • 69.24 (a)
lizard
(Anolis carolinensis)
Reptilia ELL2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ell2 35
  • 69.45 (n)
  • 69.5 (a)
Str.3600 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5308 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17099 35
ell2 35
  • 57.81 (n)
  • 55.48 (a)
ell2 36
  • 51 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5507 35
fruit fly
(Drosophila melanogaster)
Insecta Su(Tpl) 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1855 36
  • 22 (a)
OneToMany
Species with no ortholog for ELL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELL2 Gene

ENSEMBL:
Gene Tree for ELL2 (if available)
TreeFam:
Gene Tree for ELL2 (if available)

Paralogs for ELL2 Gene

Paralogs for ELL2 Gene

(3) SIMAP similar genes for ELL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ELL2: view

Variants for ELL2 Gene

Sequence variations from dbSNP and Humsavar for ELL2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_058406 -

Structural Variations from Database of Genomic Variants (DGV) for ELL2 Gene

Variant ID Type Subtype PubMed ID
dgv1819e1 CNV Complex 17122850
dgv997e201 CNV Deletion 23290073
esv2730485 CNV Deletion 23290073
esv1457060 CNV Insertion 17803354

Variation tolerance for ELL2 Gene

Residual Variation Intolerance Score: 16.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.96; 89.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELL2 Gene

HapMap Linkage Disequilibrium report
ELL2
Human Gene Mutation Database (HGMD)
ELL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELL2 Gene

Disorders for ELL2 Gene

Relevant External Links for ELL2

Genetic Association Database (GAD)
ELL2
Human Genome Epidemiology (HuGE) Navigator
ELL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELL2
genes like me logo Genes that share disorders with ELL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELL2 Gene

Publications for ELL2 Gene

  1. ELL2, a new member of an ELL family of RNA polymerase II elongation factors. (PMID: 9108030) Shilatifard A. … Conaway R.C. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 23 67
  2. The expression of androgen-responsive genes is up-regulated in the epithelia of benign prostatic hyperplasia. (PMID: 19676094) O'Malley K.J. … Wang Z. (Prostate 2009) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. The transcription elongation factor ELL2 is specifically upregulated in HTLV-1-infected T-cells and is dependent on the viral oncoprotein Tax. (PMID: 25058508) Mann M.C. … Kress A.K. (Virology 2014) 67
  5. Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. (PMID: 25238757) Park K.S. … Milcarek C. (J. Immunol. 2014) 67

Products for ELL2 Gene

Sources for ELL2 Gene

Back to Top

Content