External Ids for ELL2 Gene
Previous GeneCards Identifiers for ELL2 Gene
GeneCards Summary for ELL2 Gene
ELL2 (Elongation Factor, RNA Polymerase II, 2) is a Protein Coding gene. An important paralog of this gene is ELL3.
UniProtKB/Swiss-Prot for ELL2 Gene
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.