Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ELL Gene

protein-coding   GIFtS: 61
GCID: GC19M018553

Elongation Factor RNA Polymerase II

(Previous name: chromosome 19 open reading frame 17)
(Previous symbol: C19orf17)
  See ELL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Elongation Factor RNA Polymerase II1 2     ELL12
C19orf171 2 3     MEN2
Eleven-Nineteen Lysine-Rich Leukemia Protein2 3     PPP1R682
Chromosome 19 Open Reading Frame 171     ELL Gene (11-19 Lysine-Rich Leukemia Gene)2
Protein Phosphatase 11     Protein Phosphatase 1, Regulatory Subunit 682
Regulatory Subunit 681     RNA Polymerase II Elongation Factor ELL2

External Ids:    HGNC: 231141   Entrez Gene: 81782   Ensembl: ENSG000001056567   OMIM: 6002845   UniProtKB: P551993   

Export aliases for ELL gene to outside databases

Previous GC identifers: GC19M019048 GC19M018947 GC19M018399 GC19M018415 GC19M018416 GC19M018116


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ELL Gene:
ELL (elongation factor RNA polymerase II) is a protein-coding gene. Diseases associated with ELL include leukemia. GO annotations related to this gene include phosphatase binding. An important paralog of this gene is MARVELD2.

UniProtKB/Swiss-Prot: ELL_HUMAN, P55199
Function: Elongation factor component of the super elongation complex (SEC), a complex required to increase the
catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple
sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA
polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation
complex and early elongation

Gene Wiki entry for ELL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELL gene promoter:
         GR   Max1   GR-alpha   Nkx2-5   c-Myc   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELL promoter sequence
   Search Chromatin IP Primers for ELL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1

ELL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELL gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018553:  view genomic region     (about GC identifiers)

Start:
18,553,473 bp from pter      End:
18,632,937 bp from pter
Size:
79,465 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ELL_HUMAN, P55199 (See protein sequence)
Recommended Name: RNA polymerase II elongation factor ELL  
Size: 621 amino acids; 68265 Da
Subunit: Component of the super elongation complex (SEC), at least composed of EAF1, MLLT3/AF9, AFF (AFF1 or
AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with AFF4; the interaction is direct. Interacts
with EAF1 and EAF2
1 PDB 3D structure from and Proteopedia for ELL:
2DOA (3D)    

Explore the universe of human proteins at neXtProt for ELL: NX_P55199

Explore proteomics data for ELL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ELL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006523.1  
    ENSEMBL proteins: 
     ENSP00000262809   ENSP00000475681   ENSP00000475648  
    Reactome Protein details: P55199

    ELL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ELL
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ELL
    GenScript Custom Purified and Recombinant Proteins Services for ELL
    Novus Biologicals ELL Protein
    Novus Biologicals ELL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ELL

     
    Search eBioscience for Proteins for ELL 

     
    antibodies-online proteins for ELL (4 products) 

     
    antibodies-online peptides for ELL

    ELL Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ELL
    OriGene Custom Antibody Services for ELL
    Novus Biologicals ELL Antibodies
    Abcam antibodies for ELL
    Cloud-Clone Corp. Antibodies for ELL
    ThermoFisher Antibodies for ELL
    LSBio Antibodies in human, mouse, rat for ELL
    antibodies-online antibodies for ELL (59 products) 

    ELL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ELL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ELL
    Cloud-Clone Corp. CLIAs for ELL
    Search eBioscience for ELISAs for ELL 
    antibodies-online kits for ELL (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    2 InterPro protein domains:
     IPR019464 RNA_pol_II_elong_fac_ELL
     IPR010844 Occludin_RNApol2_elong_fac_ELL

    Graphical View of Domain Structure for InterPro Entry P55199

    ProtoNet protein and cluster: P55199

    1 Blocks protein domain: IPB010844 Occludin and RNA polymerase II elongation factor ELL

    UniProtKB/Swiss-Prot: ELL_HUMAN, P55199
    Similarity: Belongs to the ELL/occludin family


    Find genes that share domains with ELL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELL_HUMAN, P55199
    Function: Elongation factor component of the super elongation complex (SEC), a complex required to increase the
    catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple
    sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA
    polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation
    complex and early elongation

         Genatlas biochemistry entry for ELL:
    eleven-nineteen lysine-rich leukemia gene,fused with HRX(MLL) in t(11;19) acute lymphoblastic leukemia

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19389623
    GO:0019902phosphatase binding IDA19389623
         
    Find genes that share ontologies with ELL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ELL:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ell):
     mortality/aging 

    Find genes that share phenotypes with ELL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Elltm1Hhi for ELL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELL

    miRNA
    Products:
        
    miRTarBase miRNAs that target ELL:
    hsa-mir-769-3p (MIRT039101)

    Block miRNA regulation of human, mouse, rat ELL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELL (see all 68):
    hsa-miR-1321 hsa-miR-15a hsa-miR-3653 hsa-miR-30d hsa-miR-30a hsa-miR-629* hsa-miR-3622b-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidELL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ELL
    Predesigned siRNA for gene silencing in human, mouse, rat ELL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ELL

    Clone
    Products:
         
    OriGene clones in human, mouse for ELL (see all 6)
    OriGene ORF clones in mouse, rat for ELL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ELL (NM_018063)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELL
    Addgene plasmids for ELL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ELL
    Browse ESI BIO Cell Lines and PureStem Progenitors for ELL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ELL_HUMAN, P55199: Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Also
    localized to Cajal (coiled) bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0008023transcription elongation factor complex IEA--
    GO:0015030Cajal body IEA--
    GO:0016607nuclear speck IDA19389623

    Find genes that share ontologies with ELL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ELL About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of HIV elongation0.73
    HIV Transcription Elongation0.77
    HIV elongation arrest and recovery0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Polymerase II Transcription Elongation0.75
    Tat-mediated HIV elongation arrest and recovery0.72
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3Gene Expression
    Gene Expression0.40
    4Disease
    Disease


    Find genes that share SuperPaths with ELL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for ELL (see all 10)
        Pausing and recovery of Tat-mediated HIV elongation
    Formation of RNA Pol II elongation complex
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Pausing and recovery of HIV elongation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELL
    Interactions:

        GeneGlobe Interaction Network for ELL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ELL (P551991, 2, 3 ENSP000002628094) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNF8Q96H201, 2, 3, ENSP000002903304EBI-1245868,EBI-747719 MINT-7277085 MINT-7277072 MINT-7277100 I2D: score=3 STRING: ENSP00000290330
    CALM1P621583I2D: score=3 
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    MCM2P497362, 3, ENSP000002650564MINT-7277153 I2D: score=1 STRING: ENSP00000265056
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0010923negative regulation of phosphatase activity IDA19389623

    Find genes that share ontologies with ELL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ELL gene: 
    NM_006532.3  

    Unigene Cluster for ELL:

    Elongation factor RNA polymerase II
    Hs.515260  [show with all ESTs]
    Unigene Representative Sequence: NM_006532
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262809(uc002njg.3 uc002njh.3 uc010ebq.3) ENST00000594635
    ENST00000610152 ENST00000596124 ENST00000608165 ENST00000596915
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ELL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELL (see all 68):
    hsa-miR-1321 hsa-miR-15a hsa-miR-3653 hsa-miR-30d hsa-miR-30a hsa-miR-629* hsa-miR-3622b-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidELL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ELL
    Predesigned siRNA for gene silencing in human, mouse, rat ELL
    Clone
    Products:
         
    OriGene clones in human, mouse for ELL (see all 6)
    OriGene ORF clones in mouse, rat for ELL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ELL (NM_018063)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELL
    Addgene plasmids for ELL 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ELL
    OriGene qSTAR qPCR primer pairs in human, mouse for ELL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELL
      QuantiTect SYBR Green Assays in human, mouse, rat ELL
      QuantiFast Probe-based Assays in human, mouse, rat ELL

    Additional mRNA sequence: 

    AB208794.1 AF157562.1 AK225481.1 AK293105.1 AK309878.1 AL136771.1 BC010010.2 BC033673.1 
    BC049195.1 BC064558.1 BC108256.1 S77880.1 S77889.1 U16282.1 

    8 DOTS entries:

    DT.100746195  DT.411268  DT.100739993  DT.121456731  DT.97841700  DT.91681518  DT.75102546  DT.91731190 

    Selected AceView cDNA sequences (see all 166):

    BE293597 AI272237 BM680583 F11595 AL118983 BI225090 BE326983 CF593337 
    CR606202 BQ008204 BF593292 U16282 BE293559 CA434042 NM_006532 BM806318 
    BX100377 CF131209 AL543671 BM553152 AI676084 BC033673 BE293594 BE305035 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ELL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
    SP1:              -           -                                                                 -                           
    SP2:              -           -     -                                                           -                           
    SP3:                          -     -                                                           -                           
    SP4:                                                                                                                        
    SP5:              -                                                                                                         


    ECgene alternative splicing isoforms for ELL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ELL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTTGGTGT
    ELL Expression
    About this image


    ELL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    ELL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515260

    UniProtKB/Swiss-Prot: ELL_HUMAN, P55199
    Tissue specificity: Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and
    peripheral blood leukocytes

        Custom PCR Arrays for ELL
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ELL
    OriGene qSTAR qPCR primer pairs in human, mouse for ELL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELL
    QuantiTect SYBR Green Assays in human, mouse, rat ELL
    QuantiFast Probe-based Assays in human, mouse, rat ELL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ELL gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ell1 , 5 elongation factor RNA polymerase II1, 5 80.31(n)1
    83.86(a)1
      8 (34.15 cM)5
    137161  NM_007924.21  NP_031950.21 
     705396755 
    chicken
    (Gallus gallus)
    Aves ELL1 elongation factor RNA polymerase II 71.54(n)
    71.76(a)
      420124  NM_001012847.1  NP_001012865.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELL6
    elongation factor RNA polymerase II
    75(a)
    1 ↔ 1
    GL344399.1(5845-10661)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX855177.12   -- 74.13(n)    BX855177.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc60b112 wufc60b11 74.99(n)   325221  BC058072.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(Tpl)6
    Su(Tpl)
    16(a)
    1 → many
    3L(19882220-19902510)


    ENSEMBL Gene Tree for ELL (if available)
    TreeFam Gene Tree for ELL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ELL gene
    MARVELD22  ELL32  OCEL12  ELL22  
    1 SIMAP similar gene for ELL using alignment to 4 protein entries:     ELL_HUMAN (see all proteins):
    ELL2

    Find genes that share paralogs with ELL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ELL (see all 1600)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814701061,2
    --18115903(+) AGGGCC/TCTCTG 1 -- int10--------
    rs1466442741,2
    --18115911(+) CTGATA/TTGGTC 1 -- int10--------
    rs1865123241,2
    --18116047(+) CCCACA/CCCCAA 1 -- int10--------
    rs1126986241,2
    C--18141803(+) TCCAT-/ACACACA 1 -- int11Minor allele frequency- AC:0.50CSA 2
    rs1149292541,2
    C--18552985(+) CACACA/CCCACA 1 -- int10--------
    rs1147311791,2
    C--18552986(+) ACACAA/CCACAC 1 -- int10--------
    rs1145036641,2
    C--18553114(+) CCTCAC/TACCAC 1 -- int10--------
    rs3716803021,2
    C--18553131(+) AGATAC/TCCACA 1 -- int10--------
    rs2011992181,2
    C--18553138(+) CCACAC/TCCACA 1 -- int10--------
    rs2006177311,2
    --18553344(+) ACACC-/GACACAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ELL (18553473 - 18632937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ELL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657907CNV Deletion23128226
    esv2609171CNV Insertion19546169
    nsv911283CNV Loss21882294
    nsv911276CNV Loss21882294
    nsv911275CNV Loss21882294
    nsv911282CNV Loss21882294
    nsv911274CNV Loss21882294
    nsv911281CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELL
    DNA2.0 Custom Variant and Variant Library Synthesis for ELL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600284    OMIM disorders: --

    UniProtKB/Swiss-Prot: ELL_HUMAN, P55199
  • Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation
    t(11;19)(q23;p13.1) with KMT2A/MLL1. The result is a rogue activator protein

  • 1 disease for ELL:    
    About MalaCards
    leukemia

    1 disease from the University of Copenhagen DISEASES database for ELL:
    Leukemia

    Find genes that share disorders with ELL           About GenesLikeMe

    5 Novoseek inferred disease relationships for ELL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 66.2 2 9478981 (1)
    leukemia 31.1 9 15650021 (1), 19880750 (1), 19932689 (1), 11520560 (1)
    acute leukemia 29.8 2 15650021 (1)
    shock 0.265 2 15611125 (2)
    tumors 0 1 10765922 (1)


    Export disorders for ELL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ELL gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with ELL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An RNA polymerase II elongation factor encoded by the human ELL gene. (PubMed id 8596958)1, 2, 3, 9 Shilatifard A.... Conaway J.W. (Science 1996)
    2. Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. (PubMed id 7991593)1, 2, 3 Thirman M.J.... Rowley J.D. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    3. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. (PubMed id 16006523)1, 2, 9 Kong S.E.... Conaway R.C. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    4. ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. (PubMed id 12446457)1, 2, 9 Simone F.... Thirman M.J. (Blood 2003)
    5. ELL facilitates RNA polymerase II pause site entry and release. (PubMed id 22252557)1, 2 Byun J.S.... Gardner K. (Nat. Commun. 2012)
    6. The super elongation complex (SEC) family in transcriptional control. (PubMed id 22895430)1, 2 Luo Z.... Shilatifard A. (Nat. Rev. Mol. Cell Biol. 2012)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia. (PubMed id 12686606)1, 2 Polak P.E.... Thirman M.J. (Mol. Biol. Cell 2003)
    9. EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein. (PubMed id 11418481)1, 2 Simone F....Thirman M.J. (Blood 2001)
    10. Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex. (PubMed id 9268387)1, 9 Shilatifard A....Conaway J.W. (J. Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8178 HGNC: 23114 AceView: ELL Ensembl:ENSG00000105656 euGenes: HUgn8178
    ECgene: ELL H-InvDB: ELL

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ELL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ELL gene:
    Search GeneIP for patents involving ELL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ELL   OriGene RNAi products in human, mouse, rat for ELL  
     OriGene qPCR primer pairs and template standards for ELL   OriGene Protein Over-expression Lysate for ELL  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ELL  
     OriGene qSTAR qPCR primer pairs in human, mouse for ELL   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ELL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ELL   OriGene Custom Protein Services for ELL  

     
     
     Block miRNA regulation of human, mouse, rat ELL using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ELL
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELL Predesigned siRNA for gene silencing in human, mouse, rat ELL
     QuantiFast Probe-based Assays in human, mouse, rat ELL QuantiTect SYBR Green Assays in human, mouse, rat ELL
     Custom PCR Arrays for ELL Search Chromatin IP Primers for ELL
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELL  GeneGlobe Interaction Network for ELL
     Regulatory tfbs in ELL promoter
     GenScript Custom Purified and Recombinant Proteins Services for ELL GenScript cDNA clones with any tag delivered in your preferred vector for ELL
     GenScript Custom Assay Services for ELL GenScript Custom overexpressing Cell Line Services for ELL
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ELL
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ELL antibodies
     ELL proteins
     ELL lysates
     Antibodies for ELL
     See all of Abcam's Antibodies, Kits and Proteins for ELL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ELL
     Antibodies for ELL
     ELISAs for ELL
     CLIAs for ELL



     Browse ESI BIO Cell Lines and PureStem Progenitors for ELL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELL
     SwitchGear 3'UTR luciferase reporter plasmids for ELL
     SwitchGear Promoter luciferase reporter plasmids for ELL
     ThermoFisher Antibodies for ELL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELL
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELL
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELL
     LSBio Antibodies in human, mouse, rat for ELL
     Browse compounds at ApexBio
     Addgene plasmids for ELL
      Search eBioscience for proteins for ELL
      Search eBioscience for elisas for ELL
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for ELL (59 products)
     antibodies-online kits for ELL (4 products)
     antibodies-online peptides for ELL
     antibodies-online proteins for ELL (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ELL gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4