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Aliases for ELK4 Gene

Aliases for ELK4 Gene

  • ELK4, ETS Transcription Factor 2 3
  • ELK4, ETS-Domain Protein (SRF Accessory Protein 1) 2 3 5
  • Serum Response Factor Accessory Protein 1 3 4
  • SRF Accessory Protein 1 2 4
  • SAP-1 3 4
  • SAP1 3 4

External Ids for ELK4 Gene

Previous GeneCards Identifiers for ELK4 Gene

  • GC01M203506
  • GC01M201046
  • GC01M201927
  • GC01M202744
  • GC01M202762
  • GC01M202298
  • GC01M203833
  • GC01M203851
  • GC01M176751

Summaries for ELK4 Gene

Entrez Gene Summary for ELK4 Gene

  • This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELK4 Gene

ELK4 (ELK4, ETS Transcription Factor) is a Protein Coding gene. Among its related pathways are HTLV-I infection and Serotonin Receptor 2 and ELK-SRF/GATA4 signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELK4 Gene

  • Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at Lys-18 (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5side of SRF, but does not bind DNA autonomously.

Gene Wiki entry for ELK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELK4 Gene

Genomics for ELK4 Gene

Regulatory Elements for ELK4 Gene

Enhancers for ELK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELK4 Gene

Chromosome:
1
Start:
205,593,466 bp from pter
End:
205,634,085 bp from pter
Size:
40,620 bases
Orientation:
Minus strand

Genomic View for ELK4 Gene

Genes around ELK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELK4 Gene

Proteins for ELK4 Gene

  • Protein details for ELK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28324-ELK4_HUMAN
    Recommended name:
    ETS domain-containing protein Elk-4
    Protein Accession:
    P28324
    Secondary Accessions:
    • P28323
    • Q6GSJ2

    Protein attributes for ELK4 Gene

    Size:
    431 amino acids
    Molecular mass:
    46900 Da
    Quaternary structure:
    • Interacts with SIRT7.

    Three dimensional structures from OCA and Proteopedia for ELK4 Gene

    Alternative splice isoforms for ELK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELK4 Gene

Proteomics data for ELK4 Gene at MOPED

Post-translational modifications for ELK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELK4 Gene

No data available for DME Specific Peptides for ELK4 Gene

Domains & Families for ELK4 Gene

Gene Families for ELK4 Gene

Protein Domains for ELK4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28324

UniProtKB/Swiss-Prot:

ELK4_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELK4: view

Function for ELK4 Gene

Molecular function for ELK4 Gene

GENATLAS Biochemistry:
ets related protooncogene 4,homologous to murine Sap1,ubiquitously expressed,associating with a ternary complex factor 1 and SRF transcription factor and recruited to the c-fos serum response element,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function:
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at Lys-18 (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5side of SRF, but does not bind DNA autonomously.

Gene Ontology (GO) - Molecular Function for ELK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003682 chromatin binding IDA 22722849
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,NAS 7851904
GO:0005515 protein binding IPI 22722849
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ELK4: view
genes like me logo Genes that share phenotypes with ELK4: view

Animal Models for ELK4 Gene

MGI Knock Outs for ELK4:

Animal Model Products

miRNA for ELK4 Gene

miRTarBase miRNAs that target ELK4
Targeted motifs for ELK4 Gene
HOMER Transcription Factor Regulatory Elements motif ELK4
  • Consensus sequence: NRYTTCCGGY Submotif: canonical Cell Type: Hela GEO ID: GSE31477

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ELK4 Gene

Localization for ELK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELK4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELK4 Gene COMPARTMENTS Subcellular localization image for ELK4 gene
Compartment Confidence
nucleus 5
cytosol 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for ELK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ELK4: view

Pathways & Interactions for ELK4 Gene

genes like me logo Genes that share pathways with ELK4: view

SIGNOR curated interactions for ELK4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ELK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with ELK4: view

Drugs & Compounds for ELK4 Gene

No Compound Related Data Available

Transcripts for ELK4 Gene

Unigene Clusters for ELK4 Gene

ELK4, ETS-domain protein (SRF accessory protein 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELK4 Gene

No ASD Table

Relevant External Links for ELK4 Gene

GeneLoc Exon Structure for
ELK4
ECgene alternative splicing isoforms for
ELK4

Expression for ELK4 Gene

mRNA expression in normal human tissues for ELK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELK4 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ELK4 Gene



SOURCE GeneReport for Unigene cluster for ELK4 Gene Hs.497520

genes like me logo Genes that share expression patterns with ELK4: view

Protein tissue co-expression partners for ELK4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ELK4 Gene

Orthologs for ELK4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELK4 35
  • 89.4 (n)
  • 90.26 (a)
ELK4 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELK4 35
  • 84.11 (n)
  • 84.65 (a)
ELK4 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elk4 35
  • 85.63 (n)
  • 87.41 (a)
Elk4 16
Elk4 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELK4 35
  • 99.69 (n)
  • 99.07 (a)
ELK4 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elk4 35
  • 84.93 (n)
  • 86.71 (a)
oppossum
(Monodelphis domestica)
Mammalia ELK4 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELK4 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELK4 35
  • 75.66 (n)
  • 79.07 (a)
ELK4 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELK4 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elk4 35
  • 65.23 (n)
  • 66.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia elk4-A 35
zebrafish
(Danio rerio)
Actinopterygii elk4 35
  • 58.8 (n)
  • 60.24 (a)
elk4 36
  • 55 (a)
OneToOne
Species with no ortholog for ELK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELK4 Gene

ENSEMBL:
Gene Tree for ELK4 (if available)
TreeFam:
Gene Tree for ELK4 (if available)

Paralogs for ELK4 Gene

Paralogs for ELK4 Gene

(2) SIMAP similar genes for ELK4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ELK4: view

Variants for ELK4 Gene

Sequence variations from dbSNP and Humsavar for ELK4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs13757 -- 205,632,071(-) GCAGA(C/T)GCGGC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1064406 -- 205,620,446(-) CCACC(A/G)GTTGA nc-transcript-variant, reference, synonymous-codon
rs1064407 -- 205,620,155(-) TTGTC(A/C/G/T)CTGGA nc-transcript-variant, reference, synonymous-codon
rs2185811 -- 205,627,742(+) CCTAC(C/T)TCCAA intron-variant, utr-variant-5-prime
rs3065075 -- 205,627,522(+) aaaag(-/AAAAG)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELK4 Gene

Variant ID Type Subtype PubMed ID
nsv4188 CNV Insertion 18451855

Variation tolerance for ELK4 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ELK4 Gene

Disorders for ELK4 Gene

Relevant External Links for ELK4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELK4

No disorders were found for ELK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELK4 Gene

Publications for ELK4 Gene

  1. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PMID: 7851904) Shipley J. … Patel K. (Genomics 1994) 2 3 23 67
  2. Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. (PMID: 18469865) Makkonen H. … Palvimo J.J. (Oncogene 2008) 3 23
  3. c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. (PMID: 11313879) Chai Y. … Rao V.N. (Oncogene 2001) 3 23
  4. Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. (PMID: 11846562) Mo Y. … Marmorstein R. (J. Mol. Biol. 2001) 3 23
  5. Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. (PMID: 9734357) Mo Y. … Marmorstein R. (Mol. Cell 1998) 3 23

Products for ELK4 Gene

Sources for ELK4 Gene

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