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ELK4 Gene

protein-coding   GIFtS: 56
GCID: GC01M205577

ELK4, ETS-Domain Protein (SRF Accessory Protein 1)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ELK4, ETS-Domain Protein (SRF Accessory Protein 1)1 2
SAP12 3 5
Serum Response Factor Accessory Protein 12 3
SAP-12 3
ETS Domain-Containing Protein Elk-42
SRF Accessory Protein 13

External Ids:    HGNC: 33261   Entrez Gene: 20052   Ensembl: ENSG000001587117   OMIM: 6002465   UniProtKB: P283243   

Export aliases for ELK4 gene to outside databases

Previous GC identifers: GC01M203506 GC01M201046 GC01M201927 GC01M202744 GC01M202762 GC01M202298 GC01M203833 GC01M203851 GC01M176751


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELK4 Gene:
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF)
subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and
the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is
phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ELK4 Gene:
ELK4 (ELK4, ETS-domain protein (SRF accessory protein 1)) is a protein-coding gene. Diseases associated with ELK4 include prostate cancer, and prostatitis. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELF3.

UniProtKB/Swiss-Prot: ELK4_HUMAN, P28324
Function: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment
and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and
subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires
DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not
bind DNA autonomously

Gene Wiki entry for ELK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELK4 gene promoter:
         p53   FOXF2   GATA-1   S8   POU2F1   FOXO4   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ELK4 promoter sequence
   Search Chromatin IP Primers for ELK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

ELK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELK4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205577:  view genomic region     (about GC identifiers)

Start:
205,577,071 bp from pter      End:
205,602,000 bp from pter
Size:
24,930 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ELK4_HUMAN, P28324 (See protein sequence)
Recommended Name: ETS domain-containing protein Elk-4  
Size: 431 amino acids; 46900 Da
Subunit: Interacts with SIRT7
4 PDB 3D structures from and Proteopedia for ELK4:
1BC7 (3D)        1BC8 (3D)        1HBX (3D)        1K6O (3D)    
Secondary accessions: P28323 Q6GSJ2
Alternative splicing: 2 isoforms:  P28324-1   P28324-2   

Explore the universe of human proteins at neXtProt for ELK4: NX_P28324

Explore proteomics data for ELK4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ELK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001964.2  NP_068567.1  

    ENSEMBL proteins: 
     ENSP00000350681   ENSP00000289703  

    ELK4 Human Recombinant Protein Products:

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    Novus Biologicals ELK4 Proteins
    Novus Biologicals ELK4 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ELK4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ELK4
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    Novus Biologicals ELK4 Antibodies
    Abcam antibodies for ELK4 (P28324, Q6GSJ2)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ELK4
    LSBio Antibodies in human, mouse, rat for ELK4

    ELK4 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry P28324

    ProtoNet protein and cluster: P28324

    UniProtKB/Swiss-Prot: ELK4_HUMAN, P28324
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ELK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELK4_HUMAN, P28324
    Function: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment
    and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and
    subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires
    DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not
    bind DNA autonomously

         Genatlas biochemistry entry for ELK4:
    ets related protooncogene 4,homologous to murine Sap1,ubiquitously expressed,associating with a ternary complex
    factor 1 and SRF transcription factor and recruited to the c-fos serum response element,divergent member of the
    winged helix-turn-helix superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0001047core promoter binding TAS--
    GO:0003677DNA binding TAS1339307
    GO:0003682chromatin binding IDA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7851904
         
    ELK4 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Elk4):
     behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     other  skeleton  vision/eye 

    ELK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Elk4tm1Rtr for ELK4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELK4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELK4

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NRYTTCCGGY 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ELK4:
    hsa-mir-484 (MIRT041755), hsa-let-7b-5p (MIRT052289)

    Block miRNA regulation of human, mouse, rat ELK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELK4 (see all 132):
    hsa-miR-124* hsa-miR-520f hsa-miR-106a hsa-miR-1260b hsa-miR-519a hsa-miR-3622b-3p hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidELK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ELK4
    Predesigned siRNA for gene silencing in human, mouse, rat ELK4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ELK4

    Clone
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    OriGene clones in human, mouse for ELK4 (see all 12)
    OriGene ORF clones in mouse, rat for ELK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELK4 (NM_021795)
    Sino Biological Human cDNA Clone for ELK4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELK4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ELK4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELK4_HUMAN, P28324: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ELK4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELK4 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    ERK5 Signaling0.61
    2ERK Signaling
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51
    3NGF Pathway
    TRKA Signaling0.75
    4Akt Signaling
    p38 Signaling0.60
    5MAPK signaling pathway
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ELK4 (see all 8)
        FLT3 Signaling
    Rac1 Pathway
    ERK Signaling
    Molecular Mechanisms of Cancer
    TRKA Signaling

    2 GeneGo (Thomson Reuters) Pathways for ELK4
        Signal transduction JNK pathway
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades

    5 BioSystems Pathways for ELK4
        EGFR1 Signaling Pathway
    Serotonin Receptor 4/6/7 and NR3C Signaling
    Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
    Id Signaling Pathway
    Signaling mediated by p38-alpha and p38-beta



    3 Kegg Pathways  (Kegg details for ELK4):
        MAPK signaling pathway
    HTLV-I infection
    Transcriptional misregulation in cancer


    ELK4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ELK4: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ELK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for ELK4 (P283243 ENSP000003506814) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRFP118313, ENSP000002653544I2D: score=3 STRING: ENSP00000265354
    MAPK11Q157593, ENSP000003336854I2D: score=2 STRING: ENSP00000333685
    MAPK3P273613, ENSP000002630254I2D: score=2 STRING: ENSP00000263025
    BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
    ID3Q025353, ENSP000003636894I2D: score=1 STRING: ENSP00000363689
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0030154cell differentiation IBA--

    ELK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELK4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ELK4 gene (2 alternative transcripts): 
    NM_001973.3  NM_021795.2  

    Unigene Cluster for ELK4:

    ELK4, ETS-domain protein (SRF accessory protein 1)
    Hs.497520  [show with all ESTs]
    Unigene Representative Sequence: NM_001973
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357992(uc021pid.1 uc001hcy.2) ENST00000289703(uc001hcz.3)
    ENST00000468523(uc010prq.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat ELK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELK4 (see all 132):
    hsa-miR-124* hsa-miR-520f hsa-miR-106a hsa-miR-1260b hsa-miR-519a hsa-miR-3622b-3p hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidELK4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ELK4 (NM_021795)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELK4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELK4
      QuantiTect SYBR Green Assays in human, mouse, rat ELK4
      QuantiFast Probe-based Assays in human, mouse, rat ELK4

    Additional mRNA sequence: 

    AF075044.1 AK024944.1 AL117645.1 BC063676.1 M85164.1 M85165.1 

    10 DOTS entries:

    DT.97838796  DT.92423912  DT.112518  DT.97819121  DT.40298893  DT.92423913  DT.100751161  DT.91773250 
    DT.100799986  DT.100848809 

    Selected AceView cDNA sequences (see all 81):

    CK821104 BC063676 T27937 AW950095 NM_001973 AA970359 BM458403 BC040145 
    BI792972 NM_021795 BG290746 AW945159 AW150970 CK821103 CR623173 BI793265 
    BE676052 AI339924 M85164 AI005122 BX346360 BI754790 BF433322 M85165 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELK4 expression in normal human tissues (normalized intensities)      ELK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACCAAAAA
    ELK4 Expression
    About this image


    ELK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    ELK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497520
        Pathway & Disease-focused RT2 Profiler PCR Array including ELK4: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ELK4
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    QuantiFast Probe-based Assays in human, mouse, rat ELK4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ELK4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elk41 , 5 ELK4, member of ETS oncogene family1, 5 85.63(n)1
    87.41(a)1
      1 (57.24 cM)5
    137141  NM_007923.21  NP_031949.21 
     1320076075 
    chicken
    (Gallus gallus)
    Aves ELK41 ELK4, ETS-domain protein (SRF accessory protein 1) 75.66(n)
    79.07(a)
      419832  XM_417965.3  XP_417965.2 
    lizard
    (Anolis carolinensis)
    Reptilia ELK46
    ELK4, ETS-domain protein (SRF accessory protein 1)...
    70(a)
    1 ↔ 1
    GL343228.1(396439-426386)
    African clawed frog
    (Xenopus laevis)
    Amphibia elk4-A2 ELK4, ETS-domain protein (SRF accessory protein 1) 79.54(n)    AY029410.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elk42 ELK4, ETS-domain protein 75.68(n)   30093  AJ249170.1 


    ENSEMBL Gene Tree for ELK4 (if available)
    TreeFam Gene Tree for ELK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELK4 gene
    ELF32  ELF42  ELF12  ELF52  ETV72  ELK12  SPDEF2  ETV62  
    EHF2  ELF22  ELK32  
    2 SIMAP similar genes for ELK4 using alignment to 1 protein entry:     ELK4_HUMAN:
    ELF5    ELK3

    ELK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELK4 (see all 596)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358097081,2
    C--205582202(+) CATTT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs360446481,2
    C--205584231(+) AAAAA-/A/AA  
            
    GTTGA
    2 -- ut312NA CSA 4
    rs570876681,2
    C--205587144(+) AGAGA-/ATGTGTG 1 -- int10--------
    rs798803781,2
    C--205587144(+) GAGAGA/TGTGTG 1 -- int10--------
    rs679492051,2
    C--205587145(+) GAGAG-/ATTGTGT 1 -- int10--------
    rs1116337081,2
    F--205587866(+) GAATCA/GCTTGA 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs782750441,2
    C,F--205595817(+) AAATAT/CTGGCA 2 -- int12Minor allele frequency- C:0.03WA NA 238
    rs613744961,2
    C--205598316(+) AAAAA-/A/GGAAAA 2 -- int10--------
    rs1134021261,2
    C--205598876(+) TAAAG-/AAAAAA 2 -- int11Minor allele frequency- A:0.00CSA 2
    rs350181641,2
    C--205598883(+) AAAAA-/A/AA  
            
    TCCCC
    2 -- int11NA 2

    HapMap Linkage Disequilibrium report for ELK4 (205577071 - 205602000 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ELK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4188CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELK4
    DNA2.0 Custom Variant and Variant Library Synthesis for ELK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600246    OMIM disorders: --

    3 diseases for ELK4:    About MalaCards
    prostate cancer    prostatitis    breast cancer


    ELK4 for disorders           About GeneDecksing


    Export disorders for ELK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELK4 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with ELK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PubMed id 7851904)1, 3, 9 Shipley J....Patel K. (Genomics 1994)
    2. Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. (PubMed id 9734357)1, 2, 9 Mo Y.... Marmorstein R. (Mol. Cell 1998)
    3. Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes. (PubMed id 8575773)1, 3 Giovane A....Wasylyk B. (Genomics 1995)
    4. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (PubMed id 8293474)1, 2 Dalton S. and Treisman R. (Cell 1994)
    5. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (PubMed id 1339307)1, 2 Dalton S. and Treisman R. (Cell 1992)
    6. Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. (PubMed id 11846562)1, 9 Mo Y....Marmorstein R. (J. Mol. Biol. 2001)
    7. c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. (PubMed id 11313879)1, 9 Chai Y....Rao V.N. (Oncogene 2001)
    8. Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. (PubMed id 18469865)1, 9 Makkonen H....Palvimo J.J. (Oncogene 2008)
    9. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). (PubMed id 7540136)1, 9 Price M.A.... Treisman R. (EMBO J. 1995)
    10. Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation. (PubMed id 22719019)1 Zhang Y....Li H. (Cancer Discov 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2005 HGNC: 3326 AceView: ELK4 Ensembl:ENSG00000158711 euGenes: HUgn2005
    ECgene: ELK4 Kegg: 2005 H-InvDB: ELK4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ELK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELK4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ELK4 gene:
    Search GeneIP for patents involving ELK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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