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Aliases for ELK3 Gene

Aliases for ELK3 Gene

  • ELK3, ETS Transcription Factor 2 3 5
  • SRF Accessory Protein 2 2 3 4
  • ELK3, ETS-Domain Protein (SRF Accessory Protein 2) 2 3
  • Serum Response Factor Accessory Protein 2 3 4
  • ETS-Related Protein ERP 3 4
  • ETS-Related Protein NET 3 4
  • SAP-2 3 4
  • SAP2 3 4
  • NET 3 4
  • ETS Domain-Containing Protein Elk-3 3
  • ERP 3

External Ids for ELK3 Gene

Previous GeneCards Identifiers for ELK3 Gene

  • GC12P096023
  • GC12P096951
  • GC12P096521
  • GC12P095090
  • GC12P093649

Summaries for ELK3 Gene

Entrez Gene Summary for ELK3 Gene

  • This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for ELK3 Gene

ELK3 (ELK3, ETS Transcription Factor) is a Protein Coding gene. Among its related pathways are CNTF Signaling and ERK Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot for ELK3 Gene

  • May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Gene Wiki entry for ELK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELK3 Gene

Genomics for ELK3 Gene

Regulatory Elements for ELK3 Gene

Enhancers for ELK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F096419 1.7 FANTOM5 Ensembl ENCODE 31.5 +231.5 231498 12.6 PKNOX1 ZFP64 ZNF493 SIN3A BRCA1 GTF3C2 ZNF121 KLF7 ZNF548 FOS ELK3 NEDD1 CDK17 CFAP54 METAP2 SNRPF USP44 RN7SKP11 GC12P096416
GH12F096033 1.2 ENCODE 31.5 -159.1 -159144 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 NEDD1 ELK3 HAL PGAM1P5 LOC102723340 ENSG00000258272 ENSG00000258313 ENSG00000202368 ENSG00000257470 NTN4
GH12F095652 1.6 FANTOM5 Ensembl ENCODE 22.8 -540.7 -540650 2.4 ZNF133 FEZF1 YY1 ZNF302 ZNF207 FOS YY2 JUNB MXD4 REST ELK3 ENSG00000258313 ENSG00000258272 NTN4 SNRPF METAP2 LTA4H ENSG00000212448 GC12M095719
GH12F095941 1.1 ENCODE 21 -251.2 -251216 2.4 PKNOX1 ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 CBX5 ZNF263 AMDHD1 ELK3 NEDD1 METAP2 SNRPF USP44 HAL CCDC38 GC12P095914
GH12F095632 1.7 FANTOM5 Ensembl ENCODE 12.5 -556.7 -556726 10.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ENSG00000258313 ENSG00000258272 PGAM1P5 ELK3 NTN4 LTA4H ENSG00000212448 GC12M095719
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELK3 on UCSC Golden Path with GeneCards custom track

Promoters for ELK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001466256 1118 3801 PKNOX1 WRNIP1 ARID4B SIN3A ZNF2 GLIS2 ELK1 CBX5 FOS SP3

Genomic Location for ELK3 Gene

Chromosome:
12
Start:
96,194,382 bp from pter
End:
96,269,835 bp from pter
Size:
75,454 bases
Orientation:
Plus strand

Genomic View for ELK3 Gene

Genes around ELK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELK3 Gene

Proteins for ELK3 Gene

  • Protein details for ELK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41970-ELK3_HUMAN
    Recommended name:
    ETS domain-containing protein Elk-3
    Protein Accession:
    P41970
    Secondary Accessions:
    • B2R6S6
    • Q6FG57
    • Q6GU29
    • Q9UD17

    Protein attributes for ELK3 Gene

    Size:
    407 amino acids
    Molecular mass:
    44240 Da
    Quaternary structure:
    • Interacts with CTBP1.

neXtProt entry for ELK3 Gene

Post-translational modifications for ELK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELK3 Gene

No data available for DME Specific Peptides for ELK3 Gene

Domains & Families for ELK3 Gene

Gene Families for ELK3 Gene

Protein Domains for ELK3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41970

UniProtKB/Swiss-Prot:

ELK3_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELK3: view

Function for ELK3 Gene

Molecular function for ELK3 Gene

GENATLAS Biochemistry:
ets related protooncogene 3,homologous to murine Net (Erp),ubiquitous but expressed primarily at early stages of B-lymphocyte development with a drastic decline,upon B-cell maturation,activated by RAS,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function:
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Gene Ontology (GO) - Molecular Function for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12788937
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 12788937
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,NAS 7851904
GO:0003714 transcription corepressor activity IDA 12933792
genes like me logo Genes that share ontologies with ELK3: view
genes like me logo Genes that share phenotypes with ELK3: view

Animal Models for ELK3 Gene

MGI Knock Outs for ELK3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELK3 Gene

Localization for ELK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELK3 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IC 12933792
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ELK3: view

Pathways & Interactions for ELK3 Gene

genes like me logo Genes that share pathways with ELK3: view

Pathways by source for ELK3 Gene

SIGNOR curated interactions for ELK3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007165 signal transduction TAS 7958835
genes like me logo Genes that share ontologies with ELK3: view

Transcripts for ELK3 Gene

Unigene Clusters for ELK3 Gene

ELK3, ETS-domain protein (SRF accessory protein 2):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELK3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for ELK3 Gene

GeneLoc Exon Structure for
ELK3
ECgene alternative splicing isoforms for
ELK3

Expression for ELK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ELK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELK3 Gene

This gene is overexpressed in Liver (61.9) and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ELK3 Gene



Protein tissue co-expression partners for ELK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELK3 Gene:

ELK3

SOURCE GeneReport for Unigene cluster for ELK3 Gene:

Hs.46523
genes like me logo Genes that share expression patterns with ELK3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ELK3 Gene

Orthologs for ELK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELK3 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia ELK3 34 35
  • 92.7 (n)
cow
(Bos Taurus)
Mammalia ELK3 34 35
  • 92.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ELK3 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elk3 34 16 35
  • 88.86 (n)
rat
(Rattus norvegicus)
Mammalia Elk3 34
  • 88.86 (n)
oppossum
(Monodelphis domestica)
Mammalia ELK3 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELK3 34 35
  • 81.9 (n)
lizard
(Anolis carolinensis)
Reptilia ELK3 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elk3 34
  • 72.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia elk3-prov 34
zebrafish
(Danio rerio)
Actinopterygii elk3 34 35
  • 70.81 (n)
Species where no ortholog for ELK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELK3 Gene

ENSEMBL:
Gene Tree for ELK3 (if available)
TreeFam:
Gene Tree for ELK3 (if available)

Paralogs for ELK3 Gene

Paralogs for ELK3 Gene

genes like me logo Genes that share paralogs with ELK3: view

Variants for ELK3 Gene

Sequence variations from dbSNP and Humsavar for ELK3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10160897 -- 96,204,113(+) TGGTC(A/G)GTTAA intron-variant
rs10161226 -- 96,201,770(+) GAATT(G/T)AAACA intron-variant
rs10161227 -- 96,201,815(+) ATAAG(C/T)TTCCC intron-variant
rs10161271 -- 96,202,357(+) AGAAT(G/T)TTCCC intron-variant
rs1019416 -- 96,264,087(-) AGGTG(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELK3 Gene

Variant ID Type Subtype PubMed ID
nsv836 CNV insertion 18451855
nsv7234 OTHER inversion 18451855
nsv559848 CNV gain 21841781
nsv559846 CNV loss 21841781
nsv559842 CNV gain 21841781
nsv559841 CNV loss 21841781
nsv559837 CNV loss 21841781
nsv1113511 CNV deletion 24896259
nsv1035411 CNV gain 25217958
esv3630447 CNV loss 21293372
esv3549624 CNV deletion 23714750
esv26105 CNV loss 19812545
dgv858n106 CNV tandem duplication 24896259
dgv2807n54 CNV loss 21841781
dgv2806n54 CNV gain 21841781
dgv2805n54 CNV loss 21841781

Variation tolerance for ELK3 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELK3 Gene

Disorders for ELK3 Gene

Relevant External Links for ELK3

Genetic Association Database (GAD)
ELK3
Human Genome Epidemiology (HuGE) Navigator
ELK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELK3

No disorders were found for ELK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELK3 Gene

Publications for ELK3 Gene

  1. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). (PMID: 7540136) Price M.A. … Treisman R. (EMBO J. 1995) 3 4 22 64
  2. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PMID: 7851904) Shipley J. … Patel K. (Genomics 1994) 2 3 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. (PMID: 8918463) Maira S.M. … Wasylyk B. (EMBO J. 1996) 3 22 64

Products for ELK3 Gene

Sources for ELK3 Gene

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