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Aliases for ELK3 Gene

Aliases for ELK3 Gene

  • ELK3, ETS Transcription Factor 2 3
  • ELK3, ETS-Domain Protein (SRF Accessory Protein 2) 2 3 5
  • SRF Accessory Protein 2 2 3 4
  • Serum Response Factor Accessory Protein 2 3 4
  • ETS-Related Protein ERP 3 4
  • ETS-Related Protein NET 3 4

External Ids for ELK3 Gene

Previous GeneCards Identifiers for ELK3 Gene

  • GC12P096023
  • GC12P096951
  • GC12P096521
  • GC12P095090
  • GC12P093649

Summaries for ELK3 Gene

Entrez Gene Summary for ELK3 Gene

  • This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for ELK3 Gene

ELK3 (ELK3, ETS Transcription Factor) is a Protein Coding gene. Among its related pathways are ERK Signaling and Id Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELK3 Gene

  • May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Gene Wiki entry for ELK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELK3 Gene

Genomics for ELK3 Gene

Regulatory Elements for ELK3 Gene

Promoters for ELK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ELK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELK3 Gene

Chromosome:
12
Start:
96,194,382 bp from pter
End:
96,269,835 bp from pter
Size:
75,454 bases
Orientation:
Plus strand

Genomic View for ELK3 Gene

Genes around ELK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELK3 Gene

Proteins for ELK3 Gene

  • Protein details for ELK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41970-ELK3_HUMAN
    Recommended name:
    ETS domain-containing protein Elk-3
    Protein Accession:
    P41970
    Secondary Accessions:
    • B2R6S6
    • Q6FG57
    • Q6GU29
    • Q9UD17

    Protein attributes for ELK3 Gene

    Size:
    407 amino acids
    Molecular mass:
    44240 Da
    Quaternary structure:
    • Interacts with CTBP1.

neXtProt entry for ELK3 Gene

Proteomics data for ELK3 Gene at MOPED

Post-translational modifications for ELK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELK3 Gene

No data available for DME Specific Peptides for ELK3 Gene

Domains & Families for ELK3 Gene

Gene Families for ELK3 Gene

Protein Domains for ELK3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41970

UniProtKB/Swiss-Prot:

ELK3_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELK3: view

Function for ELK3 Gene

Molecular function for ELK3 Gene

GENATLAS Biochemistry:
ets related protooncogene 3,homologous to murine Net (Erp),ubiquitous but expressed primarily at early stages of B-lymphocyte development with a drastic decline,upon B-cell maturation,activated by RAS,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function:
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Gene Ontology (GO) - Molecular Function for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 12788937
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with ELK3: view
genes like me logo Genes that share phenotypes with ELK3: view

Animal Models for ELK3 Gene

MGI Knock Outs for ELK3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELK3 Gene

Localization for ELK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELK3 Gene COMPARTMENTS Subcellular localization image for ELK3 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ELK3: view

Pathways & Interactions for ELK3 Gene

genes like me logo Genes that share pathways with ELK3: view

Pathways by source for ELK3 Gene

SIGNOR curated interactions for ELK3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 7958835
GO:0042060 wound healing IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 12933792
genes like me logo Genes that share ontologies with ELK3: view

Drugs & Compounds for ELK3 Gene

No Compound Related Data Available

Transcripts for ELK3 Gene

Unigene Clusters for ELK3 Gene

ELK3, ETS-domain protein (SRF accessory protein 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELK3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for ELK3 Gene

GeneLoc Exon Structure for
ELK3
ECgene alternative splicing isoforms for
ELK3

Expression for ELK3 Gene

mRNA expression in normal human tissues for ELK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELK3 Gene

This gene is overexpressed in Liver (61.9) and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELK3 Gene



SOURCE GeneReport for Unigene cluster for ELK3 Gene Hs.46523

genes like me logo Genes that share expression patterns with ELK3: view

Protein tissue co-expression partners for ELK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ELK3 Gene

Orthologs for ELK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELK3 35
  • 99.59 (n)
  • 99.75 (a)
ELK3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELK3 36
  • 96 (a)
OneToOne
ELK3 35
  • 92.37 (n)
  • 96.02 (a)
dog
(Canis familiaris)
Mammalia ELK3 35
  • 92.7 (n)
  • 95.27 (a)
ELK3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elk3 16
Elk3 36
  • 92 (a)
OneToOne
Elk3 35
  • 88.86 (n)
  • 91.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ELK3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELK3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elk3 35
  • 88.86 (n)
  • 92.63 (a)
chicken
(Gallus gallus)
Aves ELK3 36
  • 90 (a)
OneToOne
ELK3 35
  • 81.9 (n)
  • 89.68 (a)
lizard
(Anolis carolinensis)
Reptilia ELK3 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia elk3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia elk3 35
  • 72.54 (n)
  • 79.16 (a)
zebrafish
(Danio rerio)
Actinopterygii elk3 36
  • 65 (a)
OneToOne
elk3 35
  • 70.81 (n)
  • 75.13 (a)
Species with no ortholog for ELK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELK3 Gene

ENSEMBL:
Gene Tree for ELK3 (if available)
TreeFam:
Gene Tree for ELK3 (if available)

Paralogs for ELK3 Gene

Paralogs for ELK3 Gene

genes like me logo Genes that share paralogs with ELK3: view

Variants for ELK3 Gene

Sequence variations from dbSNP and Humsavar for ELK3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs35332676 - 96,247,238(+) GGAGC(C/T)GCCCG reference, missense
rs957087 -- 96,262,982(-) TGAAA(A/G)AAAAT intron-variant
rs759769 -- 96,221,035(-) CCGAG(C/T)TGGGG intron-variant
rs1063997 -- 96,247,073(+) CAAGG(C/T)GTCTC reference, missense
rs1063998 -- 96,247,115(+) GGCCG(C/T)CCTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ELK3 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
esv26105 CNV Loss 19812545
nsv836 CNV Insertion 18451855

Variation tolerance for ELK3 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELK3 Gene

HapMap Linkage Disequilibrium report
ELK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELK3 Gene

Disorders for ELK3 Gene

Relevant External Links for ELK3

Genetic Association Database (GAD)
ELK3
Human Genome Epidemiology (HuGE) Navigator
ELK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELK3

No disorders were found for ELK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELK3 Gene

Publications for ELK3 Gene

  1. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). (PMID: 7540136) Price M.A. … Treisman R. (EMBO J. 1995) 3 4 23 67
  2. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PMID: 7851904) Shipley J. … Patel K. (Genomics 1994) 2 3 23
  3. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. (PMID: 8918463) Maira S.M. … Wasylyk B. (EMBO J. 1996) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The Oncogenic MicroRNA Hsa-miR-155-5p Targets the Transcription Factor ELK3 and Links It to the Hypoxia Response. (PMID: 25401928) Robertson E.D. … Wasylyk B. (PLoS ONE 2014) 3

Products for ELK3 Gene

Sources for ELK3 Gene

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