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ELK3 Gene

protein-coding   GIFtS: 61
GCID: GC12P096521

ELK3, ETS-Domain Protein (SRF Accessory Protein 2)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ELK3, ETS-Domain Protein (SRF Accessory Protein 2)1 2     ETS-Related Protein NET2 3
SAP22 3 5     SRF Accessory Protein 22 3
Serum Response Factor Accessory Protein 22 3     ERP2 5
NET2 3     ETS Domain-Containing Protein Elk-32
SAP-22 3     ETS-Domain Protein2
ETS-Related Protein ERP2 3     

External Ids:    HGNC: 33251   Entrez Gene: 20042   Ensembl: ENSG000001111457   OMIM: 6002475   UniProtKB: P419703   

Export aliases for ELK3 gene to outside databases

Previous GC identifers: GC12P096023 GC12P096951 GC12P095090 GC12P093649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELK3 Gene:
The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex
factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor
to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in
rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when
Ras is present. (provided by RefSeq, Jul 2008)

GeneCards Summary for ELK3 Gene:
ELK3 (ELK3, ETS-domain protein (SRF accessory protein 2)) is a protein-coding gene. Diseases associated with ELK3 include tick-borne relapsing fever, and relapsing fever. GO annotations related to this gene include purine-rich negative regulatory element binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970
Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras,
Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum
response element

Gene Wiki entry for ELK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELK3 gene promoter:
         E2F-4   E2F-3a   E2F-5   C/EBPbeta   E2F-2   CUTL1   RORalpha2   E2F   E2F-1   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELK3 promoter sequence
   Search Chromatin IP Primers for ELK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23

ELK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELK3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P096521:  view genomic region     (about GC identifiers)

Start:
96,588,160 bp from pter      End:
96,663,613 bp from pter
Size:
75,454 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970 (See protein sequence)
Recommended Name: ETS domain-containing protein Elk-3  
Size: 407 amino acids; 44240 Da
Subunit: Interacts with CTBP1
Secondary accessions: B2R6S6 Q6FG57 Q6GU29 Q9UD17

Explore the universe of human proteins at neXtProt for ELK3: NX_P41970

Explore proteomics data for ELK3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ELK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005221.2  
    ENSEMBL proteins: 
     ENSP00000228741   ENSP00000446806   ENSP00000449430   ENSP00000447857   ENSP00000449420  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry P41970

    ProtoNet protein and cluster: P41970

    UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ELK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELK3_HUMAN, P41970
    Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras,
    Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum
    response element

         Genatlas biochemistry entry for ELK3:
    ets related protooncogene 3,homologous to murine Net (Erp),ubiquitous but expressed primarily at early stages of
    B-lymphocyte development with a drastic decline,upon B-cell maturation,activated by RAS,divergent member of the
    winged helix-turn-helix superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7851904
    GO:0003714transcription corepressor activity IDA12933792
    GO:0005515protein binding IPI17474147
         
    ELK3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ELK3:
     Decreased TP53 protein express  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Elk3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  mortality/aging 
     respiratory system 

    ELK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Elk3tm1Wlyk for ELK3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELK3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELK3

    miRNA
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    miRTarBase miRNAs that target ELK3:
    hsa-mir-193b-3p (MIRT016563), hsa-mir-210-3p (MIRT003178), hsa-mir-106b-5p (MIRT020463), hsa-mir-124-3p (MIRT003523)

    Block miRNA regulation of human, mouse, rat ELK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELK3 (see all 32):
    hsa-miR-124* hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-93 hsa-miR-506 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidELK3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ELK3

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    GenScript: all cDNA clones in your preferred vector: ELK3 (NM_005230)
    Sino Biological Human cDNA Clone for ELK3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELK3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELK3_HUMAN, P41970: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    ELK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51
    2NGF Pathway
    TRKA Signaling0.75
    3CNTF Signaling
    FLT3 Signaling0.50
    4Beta-Adrenergic Signaling
    Insulin Receptor Pathway0.37
    5Id Signaling Pathway
    Id Signaling Pathway

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ELK3
        FLT3 Signaling
    ERK Signaling
    Molecular Mechanisms of Cancer
    TRKA Signaling
    Insulin Receptor Pathway

    1 BioSystems Pathway for ELK3
        Id Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELK3
    Interactions:

        GeneGlobe Interaction Network for ELK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ELK3 (P419701, 2, 3 ENSP000002287414) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8111943 I2D: score=3 STRING: ENSP00000274335
    NCK1P163331, 3, ENSP000002889864EBI-1758534,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    TCF3P159233, ENSP000002629654I2D: score=3 STRING: ENSP00000262965
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    MAPK9P459843, ENSP000003214104I2D: score=2 STRING: ENSP00000321410
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    ELK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELK3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ELK3 gene: 
    NM_005230.2  

    Unigene Cluster for ELK3:

    ELK3, ETS-domain protein (SRF accessory protein 2)
    Hs.46523  [show with all ESTs]
    Unigene Representative Sequence: NM_005230
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228741(uc001teo.1) ENST00000547249 ENST00000552142 ENST00000547860
    ENST00000549985 ENST00000549529
    miRNA
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    Block miRNA regulation of human, mouse, rat ELK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELK3 (see all 32):
    hsa-miR-124* hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-93 hsa-miR-506 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidELK3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ELK3
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    GenScript: all cDNA clones in your preferred vector: ELK3 (NM_005230)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELK3
      QuantiTect SYBR Green Assays in human, mouse, rat ELK3
      QuantiFast Probe-based Assays in human, mouse, rat ELK3

    Additional mRNA sequence: 

    AK026078.1 AK312694.1 BC017371.1 CR542251.1 Z36715.1 

    9 DOTS entries:

    DT.99932846  DT.317487  DT.40124776  DT.100044669  DT.121214954  DT.40204463  DT.91938037  DT.100791197 
    DT.40272038 

    Selected AceView cDNA sequences (see all 205):

    AA724402 BM842757 AA557143 AL705041 F12932 AI077590 AW576181 AI499197 
    F10001 BM460796 CD515292 BF476772 CA418141 AA983721 AW780068 NM_005230 
    BM998534 BM973929 F12382 BU431353 F10531 AA344225 BU902349 BG656390 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ELK3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:              -     -     -                                   -                           
    SP2:              -                                                                           
    SP3:                    -     -                                                               
    SP4:                                                              -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ELK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELK3 expression in normal human tissues (normalized intensities)      ELK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGTTAG
    ELK3 Expression
    About this image


    ELK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
             Thymus
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Kidney (Urinary System)
             Metanephros
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Brain (Nervous System)
             Medulla Oblongata
    ELK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELK3 Protein Expression

    Genevestigator expression for ELK3

    SOURCE GeneReport for Unigene cluster: Hs.46523
        Custom PCR Arrays for ELK3
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ELK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ELK3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elk31 , 5 ELK3, member of ETS oncogene family1, 5 88.86(n)1
    91.4(a)1
      10 (48.04 cM)5
    137131  NM_013508.21  NP_038536.21 
     932474145 
    chicken
    (Gallus gallus)
    Aves ELK31 ELK3, ETS-domain protein (SRF accessory protein 2) 81.9(n)
    89.68(a)
      417919  NM_001030749.1  NP_001025920.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELK36
    ELK3, ETS-domain protein (SRF accessory protein 2)...
    88(a)
    1 ↔ 1
    5(30462541-30506274)
    African clawed frog
    (Xenopus laevis)
    Amphibia elk3-prov2 ELK3, member of ETS oncogene family 75.35(n)    BC056051.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elk31 ELK3, ETS-domain protein 70.81(n)
    75.13(a)
      557074  NM_001030108.1  NP_001025279.1 


    ENSEMBL Gene Tree for ELK3 (if available)
    TreeFam Gene Tree for ELK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELK3 gene
    ELK42  ELF32  ELF42  ELF12  ELF52  ETV72  ELK12  ETV62  
    EHF2  ELF22  SPDEF2  
    16 SIMAP similar genes for ELK3 using alignment to 5 protein entries:     ELK3_HUMAN (see all proteins):
    ETV1    ETV3L    ELF5    ETS1    ELK4    ELF2
    ETV2    ETV5    ERG    DDX5-ETV4 fusion    ETV4    GABPA
    GABPAP    FEV    ELK1    EWSR1/FLI1 fusion

    ELK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELK3 (see all 1617)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73166991,2
    C,F,A,H--96425642(+) cttttT/Gtacta 1 -- us2k111Minor allele frequency- G:0.13WA NA CSA EA 374
    rs415112461,2
    C--96586208(-) AATTCG/AAACTA 1 -- us2k11Minor allele frequency- A:0.00NA 6
    rs1868765951,2
    C--96586239(+) CAGACC/TGGTTT 1 -- us2k10--------
    rs113008011,2
    C--96586299(+) GTGGA-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs1455301131,2
    C--96586595(+) ACTACC/GCACAG 1 -- us2k10--------
    rs71321011,2
    C,F,A,H--96586621(+) TGCCCG/AAAGGA 1 -- us2k1 tfbs320Minor allele frequency- A:0.39NS EA NA WA 2318
    rs1125513861,2
    C--96586652(+) TCTGAC/TAGGCA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1488539641,2
    --96586763(+) CAGGAA/GAGACT 1 -- us2k10--------
    rs1450993261,2
    --96586822(+) TTTGAA/GAGGAC 1 -- us2k10--------
    rs122976631,2
    C,F,H--96586924(+) TTAGCC/TGGGGC 1 -- us2k118Minor allele frequency- T:0.37NS EA NA WA 2342

    HapMap Linkage Disequilibrium report for ELK3 (96588160 - 96663613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ELK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv836CNV Insertion18451855
    esv26105CNV Loss19812545
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600247    OMIM disorders: --

    9 diseases for ELK3:    About MalaCards
    tick-borne relapsing fever    relapsing fever    mccune albright syndrome    lyme disease
    precocious puberty    candidiasis    labyrinthitis    hypoxia
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for ELK3:
    Lyme disease     tick-borne relapsing fever

    ELK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ELK3
    Human Genome Epidemiology (HuGE) Navigator: ELK3 (5 documents)

    Export disorders for ELK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELK3 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with ELK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). (PubMed id 7540136)1, 2, 9 Price M.A.... Treisman R. (EMBO J. 1995)
    2. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PubMed id 7851904)1, 3, 9 Shipley J....Patel K. (Genomics 1994)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Net, a new ets transcription factor that is activated by Ras. (PubMed id 7958835)1, 2 Giovane A.... Wasylyk B. (Genes Dev. 1994)
    6. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. (PubMed id 8918463)1, 9 Maira S.M....Wasylyk B. (EMBO J. 1996)
    7. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Involvement of net and Hif1alpha in distinct yet intricately linked hypoxia-induced signaling pathways. (PubMed id 20427288)1 Serchov T....Wasylyk B. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2004 HGNC: 3325 AceView: ELK3 Ensembl:ENSG00000111145 euGenes: HUgn2004
    ECgene: ELK3 H-InvDB: ELK3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ELK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ELK3 gene:
    Search GeneIP for patents involving ELK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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