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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ELK3 Gene

protein-coding   GIFtS: 62
GCID: GC12P096521

ELK3, ETS-Domain Protein (SRF Accessory Protein 2)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ELK3, ETS-Domain Protein (SRF Accessory Protein 2)1 2     ETS-Related Protein NET2 3
SAP22 3 5     SRF Accessory Protein 22 3
Serum Response Factor Accessory Protein 22 3     ERP2 5
NET2 3     ETS Domain-Containing Protein Elk-32
SAP-22 3     ETS-Domain Protein2
ETS-Related Protein ERP2 3     

External Ids:    HGNC: 33251   Entrez Gene: 20042   Ensembl: ENSG000001111457   OMIM: 6002475   UniProtKB: P419703   

Export aliases for ELK3 gene to outside databases

Previous GC identifers: GC12P096023 GC12P096951 GC12P095090 GC12P093649


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ELK3 Gene:
The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex
factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor
to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in
rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when
Ras is present. (provided by RefSeq, Jul 2008)

GeneCards Summary for ELK3 Gene: 
ELK3 (ELK3, ETS-domain protein (SRF accessory protein 2)) is a protein-coding gene. Diseases associated with ELK3 include tick-borne relapsing fever, and relapsing fever, and among its related super-pathways are Rho Family GTPases and NGF Pathway. GO annotations related to this gene include purine-rich negative regulatory element binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970
Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras,
Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum
response element

Gene Wiki entry for ELK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ELK3 gene promoter:
         E2F-4   E2F-3a   E2F-5   C/EBPbeta   E2F-2   CUTL1   RORalpha2   E2F   E2F-1   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ELK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23

ELK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELK3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P096521:  view genomic region     (about GC identifiers)

Start:
96,588,160 bp from pter      End:
96,663,613 bp from pter
Size:
75,454 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970 (See protein sequence)
Recommended Name: ETS domain-containing protein Elk-3  
Size: 407 amino acids; 44240 Da
Subunit: Interacts with CTBP1
Subcellular location: Nucleus
Secondary accessions: B2R6S6 Q6FG57 Q6GU29 Q9UD17

Explore the universe of human proteins at neXtProt for ELK3: NX_P41970

Explore proteomics data for ELK3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41970

  • ELK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ELK3 Protein Expression
    REFSEQ proteins: NP_005221.2  
    ENSEMBL proteins: 
     ENSP00000228741   ENSP00000446806   ENSP00000449430   ENSP00000447857   ENSP00000449420  

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    Browse Sino Biological Cell Lysates 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    ELK3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry P41970

    ProtoNet protein and cluster: P41970

    UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ELK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELK3_HUMAN, P41970
    Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras,
    Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum
    response element

         Genatlas biochemistry entry for ELK3:
    ets related protooncogene 3,homologous to murine Net (Erp),ubiquitous but expressed primarily at early stages of
    B-lymphocyte development with a drastic decline,upon B-cell maturation,activated by RAS,divergent member of the
    winged helix-turn-helix superfamily

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IDA12933792
    GO:0005515protein binding IPI17474147
    GO:0032422purine-rich negative regulatory element binding IDA12933792
         
    ELK3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ELK3:
     Decreased TP53 protein express  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Elk3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  mortality/aging 
     respiratory system 

    ELK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Elk3tm1Wlyk for ELK3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ELK3 
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate ELK3 (see all 32):
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    SwitchGear 3'UTR luciferase reporter plasmidELK3 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ELK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho Family GTPases
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51
    2TRKA Signaling
    TRKA Signaling0.75
    3CNTF Signaling
    FLT3 Signaling0.50
    4Erythropoietin Pathway
    Insulin Receptor Pathway0.37
    5Id Signaling Pathway
    Id Signaling Pathway

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ELK3
        FLT3 Signaling
    ERK Signaling
    Molecular Mechanisms of Cancer
    TRKA Signaling
    Insulin Receptor Pathway

    1 BioSystems Pathway for ELK3
        Id Signaling Pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ELK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for ELK3 (P419701, 2, 3 ENSP000002287414) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8111943 I2D: score=3 STRING: ENSP00000274335
    NCK1P163331, 3, ENSP000002889864EBI-1758534,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    TCF3P159233, ENSP000002629654I2D: score=3 STRING: ENSP00000262965
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    MAPK9P459843, ENSP000003214104I2D: score=2 STRING: ENSP00000321410
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007165signal transduction TAS7958835
    GO:0042060wound healing IEA--

    ELK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ELK3

    Search CenterWatch for drugs/clinical trials and news about ELK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for ELK3 gene: 
    NM_005230.2  

    Unigene Cluster for ELK3:

    ELK3, ETS-domain protein (SRF accessory protein 2)
    Hs.46523  [show with all ESTs]
    Unigene Representative Sequence: NM_005230
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228741(uc001teo.1) ENST00000547249 ENST00000552142 ENST00000547860
    ENST00000549985 ENST00000549529
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK026078.1 AK312694.1 BC017371.1 CR542251.1 Z36715.1 

    9 DOTS entries:

    DT.99932846  DT.317487  DT.40124776  DT.100044669  DT.121214954  DT.40204463  DT.91938037  DT.100791197 
    DT.40272038 

    24/205 AceView cDNA sequences (see all 205):

    AI241820 AW576181 BU753216 AA029694 BU902349 AA886353 BU431353 F12932 
    AI346154 BM460796 CA418141 AA724402 BE122722 BF476772 AW450808 BM921503 
    CA393990 CR542251 AA344225 AI088541 F10001 CD515292 Z40737 AA599413 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ELK3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:              -     -     -                                   -                           
    SP2:              -                                                                           
    SP3:                    -     -                                                               
    SP4:                                                              -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ELK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ELK3 expression in normal human tissues (normalized intensities)      ELK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGTTAG
    ELK3 Expression
    About this image


    ELK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             heart/ventricle   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
             Thymus
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
             mouse/organ system/cardiovascular system   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             brain/hindbrain   

    See ELK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ELK3

    SOURCE GeneReport for Unigene cluster: Hs.46523
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ELK3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elk31 , 5 ELK3, member of ETS oncogene family1, 5 89.43(n)1
    92.38(a)1
      10 (48.04 cM)5
    137131  NM_013508.21  NP_038536.21 
     932474145 
    chicken
    (Gallus gallus)
    Aves ELK31 ELK3, ETS-domain protein (SRF accessory protein 2) 81.9(n)
    89.68(a)
      417919  NM_001030749.1  NP_001025920.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELK36
    Uncharacterized protein
    88(a)
    1 ↔ 1
    5(30462541-30506274)
    African clawed frog
    (Xenopus laevis)
    Amphibia elk3-prov2 ELK3, member of ETS oncogene family 75.35(n)    BC056051.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elk31 ELK3, ETS-domain protein 67.46(n)
    72.07(a)
      557074  NM_001030108.1  NP_001025279.1 


    ENSEMBL Gene Tree for ELK3 (if available)
    TreeFam Gene Tree for ELK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ELK3 gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  
    ETS22  ELK12  ERG2  FEV2  ETV42  ETV22  FLI12  
    16 SIMAP similar genes for ELK3 using alignment to 5 protein entries:     ELK3_HUMAN (see all proteins):
    ETV1    ETV3L    ELF5    ETS1    ELK4    ELF2
    ETV2    ETV5    ERG    DDX5-ETV4 fusion    ETV4    GABPA
    GABPAP    FEV    ELK1    EWSR1/FLI1 fusion

    ELK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1617 SNPs in ELK3 are shown (see all 1617)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73166991,2
    C,F,A,H--96425642(+) cttttT/Gtacta 1 -- us2k111Minor allele frequency- G:0.13WA NA CSA EA 374
    rs415112461,2
    C--96586208(-) AATTCG/AAACTA 1 -- us2k11Minor allele frequency- A:0.00NA 6
    rs1868765951,2
    C--96586239(+) CAGACC/TGGTTT 1 -- us2k10--------
    rs113008011,2
    C--96586299(+) GTGGA-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs1455301131,2
    C--96586595(+) ACTACC/GCACAG 1 -- us2k10--------
    rs71321011,2
    C,F,A,H--96586621(+) TGCCCG/AAAGGA 1 -- us2k1 tfbs320Minor allele frequency- A:0.39NS EA NA WA 2318
    rs1125513861,2
    C--96586652(+) TCTGAC/TAGGCA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1488539641,2
    --96586763(+) CAGGAA/GAGACT 1 -- us2k10--------
    rs1450993261,2
    --96586822(+) TTTGAA/GAGGAC 1 -- us2k10--------
    rs122976631,2
    C,F,H--96586924(+) TTAGCC/TGGGGC 1 -- us2k118Minor allele frequency- T:0.37NS EA NA WA 2342

    HapMap Linkage Disequilibrium report for ELK3 (96588160 - 96663613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ELK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv836CNV Insertion18451855
    esv26105CNV Loss19812545
    nsv7234OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600247    OMIM disorders: --

    8 diseases for ELK3:    About MalaCards
    tick-borne relapsing fever    relapsing fever    mccune albright syndrome    lyme disease
    precocious puberty    candidiasis    hypoxia    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for ELK3:
    Lyme disease     tick-borne relapsing fever

    ELK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ELK3
    Human Genome Epidemiology (HuGE) Navigator: ELK3 (5 documents)

    Export disorders for ELK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ELK3 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with ELK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). (PubMed id 7540136)1, 2, 9 Price M.A.... Treisman R. (1995)
    2. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PubMed id 7851904)1, 3, 9 Shipley J....Patel K. (1994)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Net, a new ets transcription factor that is activated by Ras. (PubMed id 7958835)1, 2 Giovane A.... Wasylyk B. (1994)
    6. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. (PubMed id 8918463)1, 9 Maira S.M....Wasylyk B. (1996)
    7. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Involvement of net and Hif1alpha in distinct yet intr icately linked hypoxia-induced signaling pathways. (PubMed id 20427288)1 Serchov T....Wasylyk B. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2004 HGNC: 3325 AceView: ELK3 Ensembl:ENSG00000111145 euGenes: HUgn2004
    ECgene: ELK3 H-InvDB: ELK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ELK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ELK3 gene:
    Search GeneIP for patents involving ELK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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