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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ELK3 Gene

protein-coding GIFtS: 60
GCID: GC12P096521

ELK3, ETS-domain protein (SRF accessory protein 2)

Explore 10 diseases affiliated with
ELK3 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ELK3, ETS-Domain Protein (SRF Accessory Protein 2)¹ ²		ETS-Related Protein ERP² ³
SAP2¹ ² ³ ⁵		ETS-Related Protein NET² ³
NET¹ ² ³		SRF Accessory Protein 2² ³
ERP¹ ² ⁵		ETS Domain-Containing Protein Elk-3²
Serum Response Factor Accessory Protein 2² ³		ETS-Domain Protein²
SAP-2² ³

External Ids:	HGNC: 3325¹	Entrez Gene: 2004²	Ensembl: ENSG00000111145⁷	OMIM: 600247⁵	UniProtKB: P41970³

Export aliases for ELK3 gene to outside databases

Previous GC identifers: GC12P096023 GC12P096951 GC12P095090 GC12P093649

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ELK3:

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex

factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to

bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents

suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970

Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src

or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response

element

summary for ELK3:

ELK3 belongs to the ETS-domain family of transcription factors.

Gene Wiki entry for ELK3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ELK3 gene promoter:
E2F-4 E2F-3a E2F-5 C/EBPbeta E2F-2 CUTL1 RORalpha2 E2F E2F-1 COMP1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ELK3 promoter sequence

Search SABiosciences Chromatin IP Primers for ELK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q23

ELK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELK3 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P096521: view genomic region (about GC identifiers)

Start:	96,588,160 bp from pter	End:	96,663,613 bp from pter
Size:	75,454 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970 (See protein sequence)

Recommended Name: ETS domain-containing protein Elk-3

Size: 407 amino acids; 44240 Da

Subunit: Interacts with CTBP1

Subcellular location: Nucleus

Secondary accessions: B2R6S6 Q6FG57 Q6GU29 Q9UD17

Explore the universe of human proteins at neXtProt for ELK3: NX_P41970

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P41970

ELK3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005221.2

ENSEMBL proteins:

ENSP00000228741 ENSP00000446806 ENSP00000449430 ENSP00000447857 ENSP00000449420

Human Recombinant Protein Products:

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	Novus Biologicals ELK3 Proteins Novus Biologicals ELK3 Lysates
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	Uscn Proteins for ELK3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005739	mitochondrion	IDA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

ELK3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ELK3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ELK3 for domains About GeneDecksing

2 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR000418 Ets_dom

Graphical View of Domain Structure for InterPro Entry P41970

ProtoNet protein and cluster: P41970

UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ELK3_HUMAN, P41970

Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src

or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response

element

Genatlas biochemistry entry for ELK3:

ets related protooncogene 3,homologous to murine Net (Erp),ubiquitous but expressed primarily at early stages of

B-lymphocyte development with a drastic decline,upon B-cell maturation,activated by RAS,divergent member of the winged

helix-turn-helix superfamily

miRNA Products:		miRTarBase miRNAs that target ELK3: hsa-mir-210 (MIRT003178), hsa-mir-124 (MIRT003523)

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		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate ELK3 (see all 32):
		hsa-miR-124* hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-93 hsa-miR-506 hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: ELK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ELK3
		Search LifeMap BioReagents cell lines for ELK3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003714	transcription corepressor activity	IDA	12933792
GO:0005515	protein binding	IPI	17474147
GO:0032422	purine-rich negative regulatory element binding	IDA	12933792

ELK3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for ELK3:

Decreased TP53 protein express

Increased cell death HMECs cel

Animal Models:
Mouse knock-out Elk3^tm1Wlyk for ELK3
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Elk3):

behavior/neurological	cardiovascular system	homeostasis/metabolism	immune system	mortality/aging
respiratory system

ELK3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Rho Family GTPases

ERK Signaling

0.61

Molecular Mechanisms of Cancer

0.51

TRKA Signaling

TRKA Signaling

1.00

Id Signaling Pathway

Id Signaling Pathway

1.00

CNTF Signaling

FLT3 Signaling

0.50

Erythropoietin Pathway

Insulin Receptor Pathway

0.37

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ELK3

	FLT3 Signaling
	ERK Signaling
	Molecular Mechanisms of Cancer
	TRKA Signaling
	Insulin Receptor Pathway

1 BioSystems Pathway for ELK3

Id Signaling Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ELK3

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for ELK3 (P41970^{1, 2, 3} ENSP00000228741⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8111943 I2D: score=3 STRING: ENSP00000274335
NCK1	P16333¹^,³, ENSP00000288986⁴	EBI-1758534,EBI-3448658 I2D: score=2 STRING: ENSP00000288986
TCF3	P15923³, ENSP00000262965⁴	I2D: score=3 STRING: ENSP00000262965
MAPK8	P45983³, ENSP00000353483⁴	I2D: score=2 STRING: ENSP00000353483
MAPK9	P45984³, ENSP00000321410⁴	I2D: score=2 STRING: ENSP00000321410

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007165	signal transduction	TAS	7958835
GO:0042060	wound healing	IEA	--

ELK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ELK3 available from Tocris Bioscience About this table

Compound	Action	CAS #
XRP44X	Ras-Net pathway inhibitor	[729605-21-4]

Search CenterWatch for drugs/clinical trials and news about ELK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ELK3 gene:

NM_005230.2

Unigene Cluster for ELK3:

ELK3, ETS-domain protein (SRF accessory protein 2)

Hs.46523 [show with all ESTs]

Unigene Representative Sequence: NM_005230

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000228741(uc001teo.1) ENST00000547249 ENST00000552142 ENST00000547860

ENST00000549985 ENST00000549529

miRNA Products:		OriGene 3'-UTR Clone: ELK3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELK3
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate ELK3 (see all 32):
		hsa-miR-124* hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-93 hsa-miR-506 hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: ELK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELK3

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		GenScript: all cDNA clones in your preferred vector: ELK3 (NM_005230)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELK3
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELK3

Additional cDNA sequence:

AK026078.1 AK312694.1 BC017371.1 CR542251.1 Z36715.1

9 DOTS entries:

DT.99932846 DT.317487 DT.40124776 DT.100044669 DT.121214954 DT.40204463 DT.91938037 DT.100791197

DT.40272038

24/205 AceView cDNA sequences (see all 205):

BM998534 BG656390 CB852715 AI346154 F12932 AW303921 CA393990 CD515292

CR542251 AW295741 AI499197 AW576181 BE122722 AA983721 AL705041 BU431353

BM460796 BU683844 AA029694 BM023351 AI754275 BM921503 AI241820 AA599413

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ELK3 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	·	11c
SP1:					-		-		-												-
SP2:					-
SP3:							-		-
SP4:																					-
SP5:

ECgene alternative splicing isoforms for ELK3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ELK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTGTTAG

About this image

ELK3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ELK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ELK3

SOURCE GeneReport for Unigene cluster: Hs.46523

SABiosciences Custom PCR Arrays for ELK3

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELK3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ELK3 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ELK3¹	ELK3, ETS-domain protein (SRF accessory protein 2)	81.9(n) 89.68(a)		417919 NM_001030749.1 NP_001025920.1
lizard (Anolis carolinensis)	Reptilia	ELK3⁶	--	88(a)	1 ↔ 1	5(30462541-30488942)
African clawed frog (Xenopus laevis)	Amphibia	elk3-prov²	ELK3, member of ETS oncogene family	75.35(n)		BC056051.1
zebrafish (Danio rerio)	Actinopterygii	elk3¹	ELK3, ETS-domain protein	67.46(n) 72.07(a)		557074 NM_001030108.1 NP_001025279.1
worm (Caenorhabditis elegans)	Secernentea	ets-7⁶ ets-8⁶ (see all 4)	Protein ETS-8 (see all 4)	19(a) 18(a) (see all 4)	possible ortholog possible ortholog (see all 4)	V(7557738-7558764) IV(1159637-1161545)

ENSEMBL Gene Tree for ELK3 (if available)
TreeFam Gene Tree for ELK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ELK3 gene

ELK4² ETV1² ETV3² ERF² ETV5² ETV3L² ETS1² GABPA²

ETS2² ERG² FEV² ELK1² ETV4² ETV2² FLI1²

18 SIMAP similar genes for ELK3 using alignment to 5 protein entries: ELK3_HUMAN (see all proteins):

EHF ETV1 ETV3L ELF5 ETS1 ELK4

ELF2 ETV2 ETV5 ERG DDX5-ETV4 fusion ETV4

GABPA GABPAP FEV ELK1 EWSR1/FLI1 fusion FLI1

ELK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186876595^1,2		--	96586239(+)	`CAGACC/TGGTTT`	1	--	us2k¹		0	--	--	--	--
rs11300801^1,2	C	--	96586299(+)	`GTGGA-/TTTTTT`	1	--	us2k¹ trp³		1		NA	2
rs145530113^1,2		--	96586595(+)	`ACTACC/GCACAG`	1	--	us2k¹		0	--	--	--	--
rs7132101^1,2	C,F,A,H,	--	96586621(+)	`TGCCCG/AAAGGA`	1	--	us2k¹ tfbs³		20		NS EA NA WA	2318
rs148853964^1,2		--	96586763(+)	`CAGGAA/GAGACT`	1	--	us2k¹		0	--	--	--	--
rs145099326^1,2		--	96586822(+)	`TTTGAA/GAGGAC`	1	--	us2k¹		0	--	--	--	--
rs12297663^1,2	C,F,H,	--	96586924(+)	`TTAGCC/TGGGGC`	1	--	us2k¹		18		NS EA NA WA	2342
rs117682550^1,2	F,	--	96587050(+)	`GGCATG/AGGAAT`	1	--	us2k¹		1		NA	120
rs147719453^1,2		--	96587110(+)	`GGAGAA/GGCTCT`	1	--	us2k¹		0	--	--	--	--
rs191773655^1,2		--	96587315(+)	`GTTGTG/TGCTCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ELK3 (96588160 - 96663613 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ELK3
1 CNV: 71541

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ELK3

DNA2.0 Custom Variant and Variant Library Synthesis for ELK3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ELK3 for disorders           About GeneDecksing

OMIM gene information: 600247    OMIM disorders: --

10 diseases for ELK3:    About MalaCards

tick-borne relapsing fever mccune albright syndrome precocious puberty relapsing fever

lyme disease candidiasis pancreatic carcinoma pancreatitis

hypoxia carcinoma

2 diseases from the University of Copenhagen DISEASES database for ELK3:

Lyme disease tick-borne relapsing fever

Human Genome Epidemiology (HuGE) Navigator: ELK3 (5 documents)

Export disorders for ELK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ELK3 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with ELK3)

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Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). (PubMed id 7540136)^{1, 2, 9} Price M.A.... Treisman R. (1995)
Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PubMed id 7851904)^{1, 3, 9} Shipley J....Patel K. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Net, a new ets transcription factor that is activated by Ras. (PubMed id 7958835)^{1, 2} Giovane A.... Wasylyk B. (1994)
Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. (PubMed id 8918463)^{1, 9} Maira S.M....Wasylyk B. (1996)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Involvement of net and Hif1alpha in distinct yet intr icately linked hypoxia-induced signaling pathways. (PubMed id 20427288)¹ Serchov T....Wasylyk B. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2004	HGNC: 3325	AceView: ELK3	Ensembl:ENSG00000111145	euGenes: HUgn2004
ECgene: ELK3	H-InvDB: ELK3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ELK3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ELK3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ELK3 gene
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Patent Information for ELK3 gene:
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ELK3 Gene

ELK3, ETS-domain protein (SRF accessory protein 2)

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ELK3 Gene

ELK3, ETS-domain protein (SRF accessory protein 2)

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