Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ELK3 Gene

Aliases for ELK3 Gene

  • ELK3, ETS-Domain Protein (SRF Accessory Protein 2) 2 3
  • SAP2 3 4 6
  • Serum Response Factor Accessory Protein 2 3 4
  • ETS-Related Protein ERP 3 4
  • ETS-Related Protein NET 3 4
  • SRF Accessory Protein 2 3 4
  • SAP-2 3 4
  • NET 3 4
  • ERP 3 6
  • ETS Domain-Containing Protein Elk-3 3

External Ids for ELK3 Gene

Summaries for ELK3 Gene

Entrez Gene Summary for ELK3 Gene

  • This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for ELK3 Gene

ELK3 (ELK3, ETS-Domain Protein (SRF Accessory Protein 2)) is a Protein Coding gene. Diseases associated with ELK3 include tick-borne relapsing fever and relapsing fever. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and purine-rich negative regulatory element binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELK3 Gene

  • May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element

Gene Wiki entry for ELK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELK3 Gene

Genomics for ELK3 Gene

Genomic Location for ELK3 Gene

Start:
96,194,382 bp from pter
End:
96,269,835 bp from pter
Size:
75,454 bases
Orientation:
Plus strand

Genomic View for ELK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELK3 Gene

Regulatory Elements for ELK3 Gene

Proteins for ELK3 Gene

  • Protein details for ELK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41970-ELK3_HUMAN
    Recommended name:
    ETS domain-containing protein Elk-3
    Protein Accession:
    P41970
    Secondary Accessions:
    • B2R6S6
    • Q6FG57
    • Q6GU29
    • Q9UD17

    Protein attributes for ELK3 Gene

    Size:
    407 amino acids
    Molecular mass:
    44240 Da
    Quaternary structure:
    • Interacts with CTBP1

neXtProt entry for ELK3 Gene

Proteomics data for ELK3 Gene at MOPED

Post-translational modifications for ELK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELK3 Gene

No data available for DME Specific Peptides for ELK3 Gene

Domains for ELK3 Gene

Protein Domains for ELK3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ELK3_HUMAN
Domain:
  • Contains 1 ETS DNA-binding domain.:
    • P41970
Family:
  • Belongs to the ETS family.:
    • P41970
genes like me logo Genes that share domains with ELK3: view

No data available for Gene Families for ELK3 Gene

Function for ELK3 Gene

Molecular function for ELK3 Gene

GENATLAS Biochemistry: ets related protooncogene 3,homologous to murine Net (Erp),ubiquitous but expressed primarily at early stages of B-lymphocyte development with a drastic decline,upon B-cell maturation,activated by RAS,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element

Gene Ontology (GO) - Molecular Function for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12788937
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 12788937
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 7851904
genes like me logo Genes that share ontologies with ELK3: view
genes like me logo Genes that share phenotypes with ELK3: view

Animal Models for ELK3 Gene

MGI Knock Outs for ELK3:

miRNA for ELK3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ELK3 Gene

Localization for ELK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELK3 Gene COMPARTMENTS Subcellular localization image for ELK3 gene
Compartment Confidence
nucleus 5
mitochondrion 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 12933792
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ELK3: view

Pathways for ELK3 Gene

genes like me logo Genes that share pathways with ELK3: view

Pathways by source for ELK3 Gene

Gene Ontology (GO) - Biological Process for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007165 signal transduction TAS 7958835
genes like me logo Genes that share ontologies with ELK3: view

Transcripts for ELK3 Gene

Unigene Clusters for ELK3 Gene

ELK3, ETS-domain protein (SRF accessory protein 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELK3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for ELK3 Gene

GeneLoc Exon Structure for
ELK3
ECgene alternative splicing isoforms for
ELK3

Expression for ELK3 Gene

mRNA expression in normal human tissues for ELK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELK3 Gene

SOURCE GeneReport for Unigene cluster for ELK3 Gene Hs.46523

genes like me logo Genes that share expressions with ELK3: view

Orthologs for ELK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELK3 36
  • 99.59 (n)
  • 99.75 (a)
ELK3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELK3 36
  • 92.37 (n)
  • 96.02 (a)
ELK3 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELK3 36
  • 92.7 (n)
  • 95.27 (a)
ELK3 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elk3 36
  • 88.86 (n)
  • 91.4 (a)
Elk3 16
Elk3 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELK3 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELK3 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elk3 36
  • 88.86 (n)
  • 92.63 (a)
chicken
(Gallus gallus)
Aves ELK3 36
  • 81.9 (n)
  • 89.68 (a)
ELK3 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELK3 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia elk3-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia elk3 36
  • 72.54 (n)
  • 79.16 (a)
zebrafish
(Danio rerio)
Actinopterygii elk3 36
  • 70.81 (n)
  • 75.13 (a)
elk3 37
  • 65 (a)
OneToOne
Species with no ortholog for ELK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELK3 Gene

ENSEMBL:
Gene Tree for ELK3 (if available)
TreeFam:
Gene Tree for ELK3 (if available)

Paralogs for ELK3 Gene

Paralogs for ELK3 Gene

genes like me logo Genes that share paralogs with ELK3: view

Variants for ELK3 Gene

Sequence variations from dbSNP and Humsavar for ELK3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs722527 -- 96,202,444(-) CCCAA(G/T)AAAAC intron-variant
rs759769 -- 96,221,035(-) CCGAG(C/T)TGGGG intron-variant
rs957087 -- 96,262,982(-) TGAAA(A/G)AAAAT intron-variant
rs1019416 -- 96,264,087(-) AGGTG(A/G)GAGGA intron-variant
rs1030137 -- 96,222,273(-) CAAAT(A/G)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELK3 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
esv26105 CNV Loss 19812545
nsv836 CNV Insertion 18451855

Relevant External Links for ELK3 Gene

HapMap Linkage Disequilibrium report
ELK3

Disorders for ELK3 Gene

(2) University of Copenhagen DISEASES for ELK3 Gene

Relevant External Links for ELK3

Genetic Association Database (GAD)
ELK3
Human Genome Epidemiology (HuGE) Navigator
ELK3
genes like me logo Genes that share disorders with ELK3: view

No data available for UniProtKB/Swiss-Prot for ELK3 Gene

Publications for ELK3 Gene

  1. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). (PMID: 7540136) Price M.A. … Treisman R. (EMBO J. 1995) 3 4 23
  2. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PMID: 7851904) Shipley J. … Patel K. (Genomics 1994) 2 3 23
  3. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. (PMID: 8918463) Maira S.M. … Wasylyk B. (EMBO J. 1996) 3 23
  4. Net, a new ets transcription factor that is activated by Ras. (PMID: 7958835) Giovane A. … Wasylyk B. (Genes Dev. 1994) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ELK3 Gene

Sources for ELK3 Gene

Back to Top

Content