External Ids for ELK1 Gene
Previous GeneCards Identifiers for ELK1 Gene
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
GeneCards Summary for ELK1 Gene
ELK1 (ELK1, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with ELK1 include Prostate Cancer. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and MAPK targets/ Nuclear events mediated by MAP kinases. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ELK4.
UniProtKB/Swiss-Prot for ELK1 Gene
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).