Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ELK1 Gene

protein-coding   GIFtS: 66
GCID: GC0XM047494

ELK1, member of ETS oncogene family
 Explore 31 diseases affiliated with
ELK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ELK1    

Aliases
for ELK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ELK1, Member Of ETS Oncogene Family1 2
ETS Domain-Containing Protein Elk-12
ETS-Like Gene 12
Tyrosine Kinase (ELK1) Oncogene2

External Ids:    HGNC: 33211   Entrez Gene: 20022   Ensembl: ENSG000001267677   OMIM: 3110405   UniProtKB: P194193   

Export aliases for ELK1 gene to outside databases

Previous GC identifers: GC0XM046297 GC0XM045755 GC0XM046540 GC0XM047252 GC0XM047379 GC0XM045207


Summaries
for ELK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ELK1:
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily.
Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum
response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for
the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start
codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. (provided by
RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419
Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum
response factor and the ETS and SRF motifs of the fos serum response element

Gene Wiki entry for ELK1


Genomic Views
for ELK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ELK1 gene promoter:
         COUP-TF1   CREB   COUP-TF   deltaCREB   COUP   STAT3   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ELK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ELK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

ELK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELK1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM047494:  view genomic region     (about GC identifiers)

Start:
 47,494,920 bp from pter      End:
 47,510,003 bp from pter
Size:
 15,084 bases      Orientation:
 minus strand

Proteins
for ELK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419 (See protein sequence)
Recommended Name: ETS domain-containing protein Elk-1  
Size: 428 amino acids; 44888 Da
Subunit: Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity.
Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for ELK1:
1DUX (3D)    
Secondary accessions: B2R7H4 O75606 O95058 Q969X8 Q9UJM4
Alternative splicing: 2 isoforms:  P19419-1   P19419-2   

Explore the universe of human proteins at neXtProt for ELK1: NX_P19419

Post-translational modifications:

  • Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters
    • which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention1
  • On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are
    • the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum
    responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of
    sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and
    MAPK141
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P19419

    • ELK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001107595.1  NP_001244097.1  NP_005220.2  

    ENSEMBL proteins: 
     ENSP00000247161   ENSP00000467055   ENSP00000366182   ENSP00000345585  
    Reactome Protein details: P19419
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ELK1 
    GenScript Custom Purified and Recombinant Proteins Services for ELK1
    Novus Biologicals ELK1 Proteins
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ELK1
    Uscn Proteins for ELK1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--


    ELK1 for ontologies           About GeneDecksing



    ELK1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ELK1
    R&D Systems Antibodies for ELK1 (Elk-1)
    Cell Signaling Technology (CST) Antibodies for ELK1 
    OriGene Antibodies (see all 3): ELK1
    OriGene Custom Antibody Services for ELK1 
    GenScript Superior Antibodies for ELK1
    Novus Biologicals ELK1 Antibodies
    Abcam antibodies for ELK1 
    Uscn Antibodies for ELK1
    ThermoFisher Antibodies for ELK1

    Assay Products for ELK1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELK1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ELK1

    Protein Domains /
    Families
    for ELK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ELK1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry P19419

    ProtoNet protein and cluster: P19419

    UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    Function
    for ELK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419
    Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum
    response factor and the ETS and SRF motifs of the fos serum response element

         Genatlas biochemistry entry for ELK1:
    ets related protooncogene 1,activated by several mitogen-activated protein kinases (MAPKs),associating with a ternary
    complex factor 1 and SRF transcription factor and recruited to the c-fos serum response element,divergent member of
    the winged helix-turn-helix superfamily

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): ELK1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELK1
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate ELK1 (see all 74):
    hsa-miR-4254 hsa-miR-188-5p hsa-miR-631 hsa-miR-1224-3p hsa-miR-605 hsa-miR-1260b hsa-miR-219-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: ELK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELK1 (see all 7)
    OriGene shRNA RFP: ELK1
    OriGene siRNA: ELK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ELK1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELK1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELK1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ELK1 (NM_005229)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELK1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ELK1
    Search LifeMap BioReagents cell lines for ELK1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA14970218
    GO:0005515protein binding IPI17296730
    GO:0043565sequence-specific DNA binding IEA--


    ELK1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ELK1: Elk1tm2Nor Elk1tm1Nor
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Elk1):
     immune system  nervous system  reproductive system 

    ELK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ELK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/87 super-pathways (see all 87) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2Development HGF signaling pathway
    8/9 pathways (see all 9)
    		Development HGF signaling pathway1.00
    		Development EGFR signaling via small GTPases0.44
    		Development_HGF signaling pathway0.78
    		Development PDGF signaling via MAPK cascades0.41
    		Development_Neurotrophin family signaling0.45
    		Development_PDGF signaling via MAPK cascades0.41
    		Development Neurotrophin family signaling0.45
    		Signaling of Hepatocyte Growth Factor Receptor0.35
    3Development Angiotensin activation of ERK
    		Development Angiotensin activation of ERK1.00
    		Development_G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_Angiotensin activation of ERK0.98
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Development_EDNRB signaling0.54
    		Development ACM2 and ACM4 activation of ERK0.74
    		Development EDNRB signaling0.54
    4ErbB4 Pathway
    		ErbB Family Pathway0.59
    		TREM1 Pathway0.32
    		ErbB2-ErbB3 Heterodimers0.47
    		HMGB1 Pathway0.32
    		IL-2 Pathway0.46
    		Growth Hormone Signaling0.32
    		LPS Stimulated MAPK Signaling0.36
    		IL-4 Pathway0.28
    5Development_CNTF receptor signaling
    		Cell adhesion_PLAU signaling0.35
    		Immune response_IL-6 signaling pathway0.30
    		Cell adhesion PLAU signaling0.35
    		Immune response IL-6 signaling pathway0.30
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Insulin signaling pathway0.17
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/36 EMD Millipore Pathways for ELK1 (see all 36)
        Chemotaxis CXCR4 signaling pathway
    Cell adhesion PLAU signaling
    Cytoskeleton remodeling FAK signaling
    Signal transduction IP3 signaling
    Development TGF-beta receptor signaling

    1 R&D Systems Pathway for ELK1
        Adipocytokines & Insulin Signaling

    5/65 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ELK1 (see all 65)
        Molecular Mechanisms of Cancer
    JNK Pathway
    Rho Family GTPases
    ErbB Family Pathway
    RANK Signaling in Osteoclasts

    1 Cell Signaling Technology (CST) Pathway for ELK1
        MAP Kinase Signaling

    5/36 GeneGo (Thomson Reuters) Pathways for ELK1 (see all 36)
        Development A2A receptor signaling
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling
    Cell adhesion PLAU signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/27 BioSystems Pathways for ELK1 (see all 27) 
        SRF and miRs in Smooth Muscle Differentiation and Proliferation
    MAPK signaling pathway
    Focal Adhesion
    EGFR1 Signaling Pathway
    Estrogen signaling pathway

    5/27        Reactome Pathways for ELK1 (see all 27)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade

    1 PharmGKB Pathway for ELK1
        EGFR Inhibitor Pathway, Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for ELK1) (see all 8):
        MAPK signaling pathway
    ErbB signaling pathway
    Focal adhesion
    Insulin signaling pathway
    GnRH signaling pathway


    ELK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ELK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for ELK1 (P194192, 3 ENSP000002471614) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632792, 3, ENSP000003248974MINT-3380249 MINT-3380321 MINT-3380287 MINT-3380209 MINT-3380651 I2D: score=2 STRING: ENSP00000324897
    SUMO1P631652, 3, ENSP000003760764MINT-3380148 MINT-3380179 MINT-3380443 I2D: score=2 STRING: ENSP00000376076
    MAPK3P273613, ENSP000002630254I2D: score=7 STRING: ENSP00000263025
    MAPK1P284823, ENSP000002158324I2D: score=6 STRING: ENSP00000215832
    MAPK8P459833, ENSP000003534834I2D: score=4 STRING: ENSP00000353483
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----


    ELK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ELK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ELK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ELK1
    10/32 Novoseek chemical compound relationships for ELK1 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 73.1 11 11701445 (1), 11208903 (1), 11166731 (1), 15607527 (1) (see all 9)
    sp 600125 57 3 19302787 (1), 19147541 (1)
    sb 203580 51.2 2 9813041 (1), 11208903 (1)
    phosphatidylinositol 43 3 11959812 (1), 10958680 (1), 12193575 (1)
    anisomycin 41.6 5 12660819 (3), 7651411 (2)
    tyrosine 37.6 7 16515541 (3), 8208531 (2), 11443118 (1), 10958680 (1)
    threonine 30.3 2 8892757 (1), 8208531 (1)
    12-o-tetradecanoylphorbol 13-acetate 28.3 6 9880563 (1), 11050045 (1), 10535756 (1)
    wortmannin 27.5 1 15194438 (1)
    bisindolylmaleimide 24.3 3 11943676 (1), 17146445 (1)

    Search CenterWatch for drugs/clinical trials and news about ELK1 

    Transcripts
    for ELK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ELK1 gene (3 alternative transcripts): 
    NM_001114123.2  NM_001257168.1  NM_005229.4  

    Unigene Cluster for ELK1:

    ELK1, member of ETS oncogene family
    Hs.181128  [show with all ESTs]
    Unigene Representative Sequence: NM_001114123
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000247161(uc004dik.4 uc010nhv.3 uc010nhw.3 uc004dil.4)
    ENST00000592066 ENST00000376983 ENST00000480157 ENST00000468956 ENST00000343894


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ELK1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELK1
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate ELK1 (see all 74):
    hsa-miR-4254 hsa-miR-188-5p hsa-miR-631 hsa-miR-1224-3p hsa-miR-605 hsa-miR-1260b hsa-miR-219-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: ELK1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELK1 (see all 7)
    OriGene shRNA RFP: ELK1
    OriGene siRNA: ELK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELK1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELK1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELK1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ELK1 (NM_005229)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELK1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ELK1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELK1

    Additional cDNA sequence: 

    AB016193.1 AF000672.1 AK093966.1 AK312984.1 BC048296.1 BC056150.1 CR542252.1 M25269.1 

    11 DOTS entries:

    DT.100785120  DT.100785119  DT.100785117  DT.100771256  DT.102843928  DT.213807  DT.121637185  DT.92432597 
    DT.95082760  DT.97842842  DT.100035717 

    24/164 AceView cDNA sequences (see all 164):

    BM802647 BF116169 AA844141 BU501322 BM713955 BX388204 BE645946 AI363786 
    BC048296 AA655006 AI686060 BM699844 AL560620 AI264953 CN478486 BX367275 
    BC056150 BE877400 BI755351 CA489780 BM475656 AA831352 AW305143 AI203709 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ELK1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8
    SP1:                    -           -           -                                             
    SP2:                    -           -           -           -     -     -     -               
    SP3:                    -     -     -           -                                             
    SP4:                                                                                          
    SP5:                    -                                                                     


    ECgene alternative splicing isoforms for ELK1

    Expression
    for ELK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ELK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTTTCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ELK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ELK1

    SOURCE GeneReport for Unigene cluster: Hs.181128

    UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419
    Tissue specificity: Lung and testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including ELK1 (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ELK1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELK1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELK1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELK1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK1

    Orthologs
    for ELK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ELK1 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia ELK16
    		 --
    		 44(a)
    		 1 ↔ 1
    		 2(68501744-68511937)
    zebrafish
    (Danio rerio)    		 Actinopterygii elk11 ELK1, member of ETS oncogene family 56.56(n)
    52.37(a)    		   567895  XM_691202.3  XP_696294.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-11 Protein LIN-1 43.6(n)
    38.7(a)    		   177016  NM_001027880.1  NP_001023051.1 


    ENSEMBL Gene Tree for ELK1 (if available)
    TreeFam Gene Tree for ELK1 (if available) 

    Paralogs
    for ELK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ELK1 gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  
    ETS22  FEV2  ERG2  ETV42  ETV22  FLI12  ELK32  
    5 SIMAP similar genes for ELK1 using alignment to 3 protein entries:     ELK1_HUMAN (see all proteins):
    ETV6    ELF5    LOC402257    ELK3    FEV

    ELK1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ELK1
    PGOHUM00000247903 PGOHUM00000247909 PGOHUM00000250863


    Genomic Variants
    for ELK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/169 NCBI SNPs in ELK1 are shown (see all 169)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1426709191,2
    		--47494606(+) ACAGGA/TTCTTG 3 -- ds50010--------
    rs1136700791,2
    		--47494730(+) CACAAA/TCACAG 3 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1502993641,2
    		--47494767(+) GTTACC/TGATAT 3 -- ds50010--------
    rs583239301,2
    		C,--47494768(+) TTACCG/AATATG 3 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1494785851,2
    		--47494865(+) GCGTGC/TCACGC 3 -- ds50010--------
    rs1439705321,2
    		--47495210(+) TACCCA/GCCCGC 3 -- ut310--------
    rs10595871,2
    		C--47495294(-) CTGCCG/TCCTCC 3 -- ut311Minor allele frequency- T:0.00NA 2
    rs70523401,2
    		C--47495396(+) AAAATA/TGATTA 3 -- ut311Minor allele frequency- T:0.00NA 2
    rs1401119251,2
    		--47495564(+) GAAGAA/GCAAAA 3 -- ut310--------
    rs22279961,2
    		C,F,H,--47496261(-) ACCCCC/TGTGGT 5 P syn1 ut31 ese36--MN NS NA 2918

    HapMap Linkage Disequilibrium report for ELK1 (47494920 - 47510003 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ELK1: --
    Human Gene Mutation Database (HGMD): ELK1

    Locus Specific Mutation Databases (LSDB): ELK1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ELK1
    DNA2.0 Custom Variant and Variant Library Synthesis for ELK1

    Disorders / Diseases
    for ELK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ELK1 for disorders           About GeneDecksing

    OMIM gene information: 311040    OMIM disorders: --

    20/31 diseases for ELK1 (see all 31):    About MalaCards
    human t-cell leukemia virus type 1    esophageal squamous cell carcinoma    squamous cell carcinoma    prion disease
    insulin resistance    choriocarcinoma    hepatocellular carcinoma    t-cell leukemia
    embryonal carcinoma    neurodegenerative disease    hepatitis c    insulinoma
    leishmaniasis    astrocytoma    carcinoma    breast cancer
    endometrial cancer    prostatitis    leukemia    esophagitis

    10/13 Novoseek disease relationships for ELK1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 37.5 1 16369914 (1)
    tumors 24.2 6 10514437 (1), 10934204 (1), 11050045 (1), 17203534 (1) (see all 6)
    prostate cancer 16.2 1 18712680 (1)
    necrosis 10.7 2 10913190 (1), 11520792 (1)
    breast cancer 9.31 7 11313879 (2), 9696047 (2), 11773443 (1), 19170108 (1)
    choriocarcinoma 2.48 1 15829977 (1)
    astrocytoma 0 1 9917510 (1)
    leukemia 0 2 2250910 (1), 20362031 (1)
    shock 0 2 10969830 (1), 8562482 (1)
    inflammation 0 1 18752500 (1)

    Human Genome Epidemiology (HuGE) Navigator: ELK1 (4 documents)
    Tumor Gene Database (TGDB): ELK1

    Export disorders for ELK1 gene to outside databases

    Publications
    for ELK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ELK1 gene, integrated from 9 sources (see all 439):
    (articles sorted by number of sources associating them with ELK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. (PubMed id 2539641)1, 2, 3 Rao V.N....Reddy E.S.P. (1989)
    2. SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. (PubMed id 15210726)1, 2, 9 Salinas S.... Hipskind R.A. (2004)
    3. PIASx acts as an Elk-1 coactivator by facilitating derepression. (PubMed id 15920481)1, 2, 9 Yang S.-H. and Sharrocks A.D. (2005)
    4. Elk-1 protein domains required for direct and SRF-assisted DNA- binding. (PubMed id 1630903)1, 2, 9 Janknecht R. and Nordheim A. (1992)
    5. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. (PubMed id 12887893)1, 2, 9 Yang S.-H.... Sharrocks A.D. (2003)
    6. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. (PubMed id 7889942)1, 2, 9 Gille H.... Shaw P.E. (1995)
    7. Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. (PubMed id 10742173)1, 2, 9 Mo Y.... Marmorstein R. (2000)
    8. Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes. (PubMed id 10231026)1, 2, 9 Yamauchi T.... Isobe M. (1999)
    9. Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. (PubMed id 17296730)1, 2, 9 Zhang L....Sharrocks A.D. (2007)
    10. The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus. (PubMed id 9795224)1, 2, 9 Harindranath N.... Max E.E. (1998)

    External Searches for ELK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ELK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2002 HGNC: 3321 AceView: ELK1 Ensembl:ENSG00000126767 euGenes: HUgn2002
    ECgene: ELK1 Kegg: 2002 H-InvDB: ELK1

    Other Databases showing ELK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ELK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ELK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELK1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ELK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ELK1 gene:
    Search GeneIP for patents involving ELK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ELK1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of ELK1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ELK1 (Elk-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ELK1   OriGene shRNA RFP for ELK1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELK1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ELK1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ELK1   OriGene 3'-UTR Clone for ELK1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELK1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELK1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ELK1   OriGene Custom Protein Services for ELK1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ELK1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ELK1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELK1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELK1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELK1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELK1
     GenScript Custom Purified and Recombinant Proteins Services for ELK1 GenScript cDNA clones with any tag delivered in your preferred vector for ELK1
     GenScript Custom Assay Services for ELK1 GenScript Superior Antibodies for ELK1
     GenScript Custom overexpressing Cell Line Services for ELK1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ELK1 

     Regulatory tfbs in ELK1 promoter
     Search Chromatin IP Primers for ELK1
     RT2 qPCR Primer Assay in human, mouse, rat ELK1
     GNC Network for ELK1
     SABiosciences PCR Arrays including human, mouse, rat ELK1
     Search Tocris compounds for ELK1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ELK1 antibodies
     ELK1 proteins
     Antibodies for ELK1
     See all of Abcam's Antibodies, Kits and Proteins for ELK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ELK1




     ELK1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ELK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK1
     SwitchGear 3'UTR luciferase reporter plasmids for ELK1
     SwitchGear Promoter luciferase reporter plasmids for ELK1
     ThermoFisher Antibodies for ELK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELK1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ELK1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4