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ELK1 Gene

protein-coding   GIFtS: 69
GCID: GC0XM047494

ELK1, Member Of ETS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ELK1, Member Of ETS Oncogene Family1 2
ETS Domain-Containing Protein Elk-12
ETS-Like Gene 12
Tyrosine Kinase (ELK1) Oncogene2

External Ids:    HGNC: 33211   Entrez Gene: 20022   Ensembl: ENSG000001267677   OMIM: 3110405   UniProtKB: P194193   

Export aliases for ELK1 gene to outside databases

Previous GC identifers: GC0XM046297 GC0XM045755 GC0XM046540 GC0XM047252 GC0XM047379 GC0XM045207


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELK1 Gene:
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF)
subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and
the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a
nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative
translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7
and 14. (provided by RefSeq, Mar 2012)

GeneCards Summary for ELK1 Gene:
ELK1 (ELK1, member of ETS oncogene family) is a protein-coding gene. Diseases associated with ELK1 include bladder transitional cell carcinoma, and transitional cell carcinoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419
Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum
response factor and the ETS and SRF motifs of the fos serum response element

Gene Wiki entry for ELK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELK1 gene promoter:
         COUP-TF1   CREB   COUP-TF   deltaCREB   COUP   STAT3   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELK1 promoter sequence
   Search Chromatin IP Primers for ELK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

ELK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELK1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM047494:  view genomic region     (about GC identifiers)

Start:
47,494,920 bp from pter      End:
47,510,003 bp from pter
Size:
15,084 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419 (See protein sequence)
Recommended Name: ETS domain-containing protein Elk-1  
Size: 428 amino acids; 44888 Da
Subunit: Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity.
Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9
1 PDB 3D structure from and Proteopedia for ELK1:
1DUX (3D)    
Secondary accessions: B2R7H4 O75606 O95058 Q969X8 Q9UJM4
Alternative splicing: 2 isoforms:  P19419-1   P19419-2   

Explore the universe of human proteins at neXtProt for ELK1: NX_P19419

Explore proteomics data for ELK1 at MOPED

Post-translational modifications: 

  • Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene
    promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates
    nuclear retention1
  • On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389
    are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with
    the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation
    leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by
    CAMK4, MAPK11, MAPK12 and MAPK141
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ELK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001107595.1  NP_001244097.1  NP_005220.2  

    ENSEMBL proteins: 
     ENSP00000247161   ENSP00000467055   ENSP00000366182   ENSP00000345585  
    Reactome Protein details: P19419

    ELK1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ELK1
    GenScript Custom Purified and Recombinant Proteins Services for ELK1
    Novus Biologicals ELK1 Proteins
    Sino Biological Recombinant Protein for ELK1
    Sino Biological Cell Lysate for ELK1
    ProSpec Recombinant Protein for ELK1
    Cloud-Clone Corp. Proteins for ELK1

    ELK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ELK1
    R&D Systems Antibodies for ELK1 (Elk-1)
    Cell Signaling Technology (CST) Antibodies for ELK1 
    OriGene Antibodies for ELK1
    OriGene Custom Antibody Services for ELK1
    Novus Biologicals ELK1 Antibodies
    Abcam antibodies for ELK1
    Cloud-Clone Corp. Antibodies for ELK1
    ThermoFisher Antibodies for ELK1
    LSBio Antibodies in human, mouse, rat for ELK1

    ELK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ELK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ELK1
    Cloud-Clone Corp. CLIAs for ELK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry P19419

    ProtoNet protein and cluster: P19419

    UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ELK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELK1_HUMAN, P19419
    Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum
    response factor and the ETS and SRF motifs of the fos serum response element

         Genatlas biochemistry entry for ELK1:
    ets related protooncogene 1,activated by several mitogen-activated protein kinases (MAPKs),associating with a
    ternary complex factor 1 and SRF transcription factor and recruited to the c-fos serum response element,divergent
    member of the winged helix-turn-helix superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA14970218
    GO:0005515protein binding IPI17036045
    GO:0043565sequence-specific DNA binding IEA--
         
    ELK1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Elk1):
     immune system  nervous system  reproductive system 

    ELK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ELK1: Elk1tm1Nor Elk1tm2Nor

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELK1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  HACTTCCGGY 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ELK1:
    hsa-mir-186-5p (MIRT021088)

    Block miRNA regulation of human, mouse, rat ELK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELK1 (see all 74):
    hsa-miR-4254 hsa-miR-188-5p hsa-miR-631 hsa-miR-1224-3p hsa-miR-605 hsa-miR-1260b hsa-miR-219-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidELK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ELK1
    Predesigned siRNA for gene silencing in human, mouse, rat ELK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ELK1

    Clone
    Products:
         
    OriGene clones in human, mouse for ELK1 (see all 12)
    OriGene ORF clones in mouse, rat for ELK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELK1 (NM_005229)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELK1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ELK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ELK1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELK1_HUMAN, P19419: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    ELK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELK1 About   (see all 87)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Immune response IL 4 signaling pathway0.39
    Development IGF 1 receptor signaling0.48
    3Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    4MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    5Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Development PDGF signaling via MAPK cascades0.41
    Development Neurotrophin family signaling0.45
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development EGFR signaling via small GTPases0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ELK1
        Adipocytokines & Insulin Signaling

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ELK1 (see all 65)
        Molecular Mechanisms of Cancer
    JNK Pathway
    Rho Family GTPases
    ErbB Family Pathway
    RANK Signaling in Osteoclasts

    1 Cell Signaling Technology (CST) Pathway for ELK1
        MAP Kinase Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ELK1 (see all 36)
        Development A2A receptor signaling
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling
    Cell adhesion PLAU signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for ELK1 (see all 30)
        MAPK signaling pathway
    Focal Adhesion
    EGFR1 Signaling Pathway
    Insulin Signaling
    Estrogen signaling pathway

    2 Sino Biological Pathways for ELK1
        TNF Signaling
    EGFR Signaling Pathway

    1 Reactome Pathway for ELK1
        ERK/MAPK targets

    1 PharmGKB Pathway for ELK1
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ELK1) (see all 13):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Focal adhesion
    Insulin signaling pathway


    ELK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ELK1 (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ELK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ELK1 (P194191, 2, 3 ENSP000002471614) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632791, 2, 3, ENSP000003248974EBI-726632,EBI-80168 MINT-3380249 MINT-3380321 MINT-3380287 MINT-3380209 MINT-3380651 I2D: score=2 STRING: ENSP00000324897
    SUMO1P631651, 2, 3, ENSP000003760764EBI-726632,EBI-80140 MINT-3380148 MINT-3380179 MINT-3380443 I2D: score=2 STRING: ENSP00000376076
    MAPK3P273613, ENSP000002630254I2D: score=7 STRING: ENSP00000263025
    MAPK1P284823, ENSP000002158324I2D: score=6 STRING: ENSP00000215832
    MAPK8P459833, ENSP000003534834I2D: score=4 STRING: ENSP00000353483
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----

    ELK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELK1

    Selected Novoseek inferred chemical compound relationships for ELK1 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 73.1 11 11701445 (1), 11208903 (1), 11166731 (1), 15607527 (1) (see all 9)
    sp 600125 57 3 19302787 (1), 19147541 (1)
    sb 203580 51.2 2 9813041 (1), 11208903 (1)
    phosphatidylinositol 43 3 11959812 (1), 10958680 (1), 12193575 (1)
    anisomycin 41.6 5 12660819 (3), 7651411 (2)
    tyrosine 37.6 7 16515541 (3), 8208531 (2), 11443118 (1), 10958680 (1)
    threonine 30.3 2 8892757 (1), 8208531 (1)
    12-o-tetradecanoylphorbol 13-acetate 28.3 6 9880563 (1), 11050045 (1), 10535756 (1)
    wortmannin 27.5 1 15194438 (1)
    bisindolylmaleimide 24.3 3 11943676 (1), 17146445 (1)



    ELK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ELK1 gene (3 alternative transcripts): 
    NM_001114123.2  NM_001257168.1  NM_005229.4  

    Unigene Cluster for ELK1:

    ELK1, member of ETS oncogene family
    Hs.181128  [show with all ESTs]
    Unigene Representative Sequence: NM_001114123
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000247161(uc004dik.4 uc010nhv.3 uc010nhw.3 uc004dil.4)
    ENST00000592066 ENST00000376983 ENST00000480157 ENST00000468956 ENST00000343894

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ELK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELK1 (see all 74):
    hsa-miR-4254 hsa-miR-188-5p hsa-miR-631 hsa-miR-1224-3p hsa-miR-605 hsa-miR-1260b hsa-miR-219-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidELK1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ELK1
    Predesigned siRNA for gene silencing in human, mouse, rat ELK1
    Clone
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    OriGene clones in human, mouse for ELK1 (see all 12)
    OriGene ORF clones in mouse, rat for ELK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELK1 (NM_005229)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELK1
    Primer
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    OriGene qPCR primer pairs and template standards for ELK1
    OriGene qSTAR qPCR primer pairs in human, mouse for ELK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELK1
      QuantiTect SYBR Green Assays in human, mouse, rat ELK1
      QuantiFast Probe-based Assays in human, mouse, rat ELK1

    Additional mRNA sequence: 

    AB016193.1 AF000672.1 AK093966.1 AK312984.1 BC048296.1 BC056150.1 CR542252.1 M25269.1 

    11 DOTS entries:

    DT.100785120  DT.100785119  DT.100785117  DT.100771256  DT.102843928  DT.213807  DT.121637185  DT.92432597 
    DT.95082760  DT.97842842  DT.100035717 

    Selected AceView cDNA sequences (see all 164):

    AI686060 BX493565 BC056150 AA732043 BC048296 BX367275 BX388204 BU501322 
    AW305143 AI203709 AL560620 BM802647 AA831352 AA655006 BM475656 CA489780 
    CR598341 AA844141 BM699844 BE293251 BI755351 CR542252 AA576028 BE877400 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ELK1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8
    SP1:                    -           -           -                                             
    SP2:                    -           -           -           -     -     -     -               
    SP3:                    -     -     -           -                                             
    SP4:                                                                                          
    SP5:                    -                                                                     


    ECgene alternative splicing isoforms for ELK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ELK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTCAGT
    ELK1 Expression
    About this image


    ELK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Neural Tube (Nervous System)
             Telencephalon
    ELK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181128

    UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419
    Tissue specificity: Lung and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ELK1 (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ELK1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elk11 , 5 ELK1, member of ETS oncogene family1, 5 84.15(n)1
    85.48(a)1
      X (16.45 cM)5
    137121  NM_007922.51  NP_031948.41 
     209333955 
    lizard
    (Anolis carolinensis)
    Reptilia ELK16
    ELK1, member of ETS oncogene family
    51(a)
    1 ↔ 1
    2(68501744-68511937)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004976091 ETS domain-containing protein Elk-1-like 59.93(n)
    58.79(a)
      100497609  XM_004919747.1  XP_004919804.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elk16
    ELK1, member of ETS oncogene family
    39(a)
    1 ↔ 1
    8(9257429-9294426) ENSDARG00000078066


    ENSEMBL Gene Tree for ELK1 (if available)
    TreeFam Gene Tree for ELK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELK1 gene
    ELK42  ELF32  ELF42  ELF12  ELF52  ETV72  SPDEF2  ETV62  
    EHF2  ELF22  ELK32  
    6 SIMAP similar genes for ELK1 using alignment to 3 protein entries:     ELK1_HUMAN (see all proteins):
    ETV6    ELF5    LOC402257    ERF    ELK3    FEV

    ELK1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ELK1
    PGOHUM00000247903 PGOHUM00000247909 PGOHUM00000250863


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELK1 (see all 238)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426709191,2
    --47414174(+) ACAGGA/TTCTTG 3 -- ds50010--------
    rs1136700791,2
    F--47414298(+) CACAAA/TCACAG 3 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1502993641,2
    --47414335(+) GTTACC/TGATAT 3 -- ds50010--------
    rs583239301,2
    C,F--47414336(+) TTACCG/AATATG 3 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1494785851,2
    C--47414433(+) GCGTGC/TCACGC 3 -- ds50010--------
    rs1439705321,2
    C--47414778(+) TACCCA/GCCCGC 3 -- ut310--------
    rs10595871,2
    C--47414862(-) CTGCCG/TCCTCC 3 -- ut311Minor allele frequency- T:0.00NA 2
    rs70523401,2
    C--47414964(+) AAAATA/TGATTA 3 -- ut311Minor allele frequency- T:0.00NA 2
    rs1401119251,2
    --47415132(+) GAAGAA/GCAAAA 3 -- ut310--------
    rs22279961,2
    C,F,H--47415829(-) ACCCCC/TGTGGT 5 P syn1 ut31 ese36--MN NS NA 2918

    HapMap Linkage Disequilibrium report for ELK1 (47494920 - 47510003 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ELK1: --
    Human Gene Mutation Database (HGMD): ELK1
    Locus Specific Mutation Databases (LSDB): ELK1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELK1
    DNA2.0 Custom Variant and Variant Library Synthesis for ELK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 311040    OMIM disorders: --

    Selected diseases for ELK1 (see all 40):    
    About MalaCards
    bladder transitional cell carcinoma    transitional cell carcinoma    prion disease    choriocarcinoma
    human t-cell leukemia virus type 1    insulinoma    astrocytoma    leishmaniasis
    esophageal squamous cell carcinoma    leprosy    t-cell leukemia    hypoxia
    huntington's disease    hepatocellular carcinoma    insulin resistance    hepatitis c virus
    prostatitis    colon adenocarcinoma    osteosarcoma    prostate cancer


    ELK1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ELK1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 37.5 1 16369914 (1)
    tumors 24.2 6 10514437 (1), 10934204 (1), 11050045 (1), 17203534 (1) (see all 6)
    prostate cancer 16.2 1 18712680 (1)
    necrosis 10.7 2 10913190 (1), 11520792 (1)
    breast cancer 9.31 7 11313879 (2), 9696047 (2), 11773443 (1), 19170108 (1)
    choriocarcinoma 2.48 1 15829977 (1)
    astrocytoma 0 1 9917510 (1)
    leukemia 0 2 2250910 (1), 20362031 (1)
    shock 0 2 10969830 (1), 8562482 (1)
    inflammation 0 1 18752500 (1)

    Genetic Association Database (GAD): ELK1
    Human Genome Epidemiology (HuGE) Navigator: ELK1 (4 documents)
    Tumor Gene Database (TGDB): ELK1

    Export disorders for ELK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELK1 gene, integrated from 10 sources (see all 458):
    (articles sorted by number of sources associating them with ELK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. (PubMed id 2539641)1, 2, 3 Rao V.N....Reddy E.S.P. (Science 1989)
    2. SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. (PubMed id 15210726)1, 2, 9 Salinas S.... Hipskind R.A. (J. Cell Biol. 2004)
    3. PIASx acts as an Elk-1 coactivator by facilitating derepression. (PubMed id 15920481)1, 2, 9 Yang S.-H. and Sharrocks A.D. (EMBO J. 2005)
    4. Elk-1 protein domains required for direct and SRF-assisted DNA- binding. (PubMed id 1630903)1, 2, 9 Janknecht R. and Nordheim A. (Nucleic Acids Res. 1992)
    5. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. (PubMed id 12887893)1, 2, 9 Yang S.-H.... Sharrocks A.D. (Mol. Cell 2003)
    6. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. (PubMed id 7889942)1, 2, 9 Gille H.... Shaw P.E. (EMBO J. 1995)
    7. Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. (PubMed id 10742173)1, 2, 9 Mo Y.... Marmorstein R. (Nat. Struct. Biol. 2000)
    8. Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes. (PubMed id 10231026)1, 2, 9 Yamauchi T.... Isobe M. (DNA Res. 1999)
    9. Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. (PubMed id 17296730)1, 2, 9 Zhang L.... Sharrocks A.D. (Mol. Cell. Biol. 2007)
    10. The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus. (PubMed id 9795224)1, 2, 9 Harindranath N.... Max E.E. (Gene 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2002 HGNC: 3321 AceView: ELK1 Ensembl:ENSG00000126767 euGenes: HUgn2002
    ECgene: ELK1 Kegg: 2002 H-InvDB: ELK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELK1 gene:
    Search GeneIP for patents involving ELK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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