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ELK1 Gene

protein-coding GIFtS: 66

GC0XM047379

ELK1, member of ETS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000023224 ^²
OTTHUMP00000023225 ^²

Descriptions
ELK1 protein ^²
ELK1, member of ETS oncogene family ^²
ETS-like gene 1 ^²

External Ids
HGNC: 3321¹
Entrez Gene: 2002²
UniProtKB: P19419³
Ensembl: ENSG00000126767⁷

Search outside databases for aliases for ELK1 gene

Previous GC identifers: GC0XM046297 GC0XM045755 GC0XM046540 GC0XM047252

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ELK1:

This gene is a member of the Ets family of transcription factors and of the ternary complex factor

(TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum

response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The

protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade.

Alternatively spliced transcript variants encoding the same protein have been found for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419

Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex

with the serum response factor and the ETS and SRF motifs of the fos serum response element

Gene Wiki entry for ELK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ELK1 gene

Entrez Gene cytogenetic band: Xp11.2 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23

ELK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM047379: (about GC identifiers)

Start:	47,379,864 bp from pter
End:	47,394,964 bp from pter
Size:	15,101 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419 (See protein sequence)

Recommended Name: ETS domain-containing protein Elk-1

Size: 428 amino acids; 44888 Da

Subunit: Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional

activator activity

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1DUX (3D)

Secondary accessions: O75606 O95058 Q969X8 Q9UJM4

Alternative splicing: 2 isoforms: P19419-1 P19419-2

Post-translational modifications:

Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to

target gene promoters which leads to decreased histone acetylation and reduced transactivator

activity. It also regulates nuclear retention¹

On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1.

Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1

potentiates ternary complex formation with the serum responses factors, SRE and SRF.

Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001107595.1 NP_005220.2

ENSEMBL proteins:

ENSP00000247161 ENSP00000345585 ENSP00000366182 ENSP00000366184

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ELK1)
	Human Recombinant Proteins from Abnova (ELK1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IC	14970218

About this table

Antibodies for ELK1:

	Invitrogen Antibodies for ELK1
	Millipore Mono- and Polyclonal Antibodies for the study of ELK1
	Sigma-Aldrich Antibodies for ELK1
	R&D Systems Antibodies for ELK1 (Elk-1)
	Cell Signaling Technology (CST) Antibodies for ELK1 (Elk-1)
	Antibodies from Abcam (ELK1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ELK1)
	Novus Biologicals Antibodies for ELK1

Assays for ELK1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P19419

ProtoNet protein and cluster: P19419

UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ELK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ELK1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001114123

Applied Biosystems Silencer® siRNAs for ELK1

Sigma-Aldrich siRNA for ELK1

Sigma-Aldrich shRNA for ELK1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ELK1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114123
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114123
untagged cDNA clones in CMV expression vector (see all 2): NM_001114123

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001114123

UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419

Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex

with the serum response factor and the ETS and SRF motifs of the fos serum response element

Genatlas biochemistry entry for ELK1:

ets related protooncogene 1,activated by several mitogen-activated protein kinases

(MAPKs),associating with a ternary complex factor 1 and SRF transcription factor and recruited to

the c-fos serum response element,divergent member of the winged helix-turn-helix superfamily

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Elk1):

immune system

nervous system

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	14970218
GO:0005515	protein binding	IPI	16291755 16533805
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/41 Sigma-Aldrich "Your Favorite Gene" Pathways for ELK1 (Your Favorite Gene powered by Ingenuity) (see all 41 )

Endometrial Cancer Signaling
Growth Hormone Signaling
GM-CSF Signaling
Renin-Angiotensin Signaling
Antiproliferative Role of Somatostatin Receptor 2

GeneDecks ELK1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ELK1

5/35 Interacting proteins for ELK1 (P19419^{1, 2} ENSP00000366184³) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK1	P28482¹, ENSP00000215832³	EBI-726632, EBI-959949 STRING (score=.999)
MAPK3	P27361¹, ENSP00000263025³	EBI-726632, EBI-73995 STRING (score=.999)
Mapk1 Mapk1 (xeno)	P63085¹	EBI-726632, EBI-397697
UBE2I	P63279²	MINT-3380249 MINT-3380321 MINT-3380287 MINT-3380209 MINT-3380651
SUMO1	P63165²	MINT-3380148 MINT-3380179 MINT-3380443

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	14970218

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ELK1
10/19 Novoseek chemical compound relationships for ELK1 gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pd 98,059	73.88	11	11701445 (1), 11208903 (1), 11166731 (1), 15607527 (1) (see all 9)
sp 600125	53.58	3	19302787 (1), 19147541 (1)
phosphatidylinositol	43.12	3	11959812 (1), 10958680 (1), 12193575 (1)
tyrosine	38.60	7	16515541 (3), 8208531 (2), 11443118 (1), 10958680 (1)
12-o-tetradecanoylphorbol 13-acetate	29.60	6	9880563 (1), 11050045 (1), 10535756 (1)
threonine	29.47	2	8892757 (1), 8208531 (1)
wortmannin	29.32	1	15194438 (1)
bisindolylmaleimide	25.69	3	11943676 (1), 17146445 (1)
forskolin	15.81	5	9512670 (1), 10406459 (1), 9165004 (1)
ionomycin	8.88	3	9367995 (1), 11402055 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ELK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ELK1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001114123

Sigma-Aldrich siRNA for ELK1

Sigma-Aldrich shRNA for ELK1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001114123 NM_005229

REFSEQ mRNAs for ELK1 gene (2 alternative transcripts):

NM_001114123.1 NM_005229.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001114123 NM_005229

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114123
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114123
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001114123

Additional cDNA sequence:

AB016193.1 AB209047.1 AF000672.1 AK093966.1 AK312984.1 BC048296.1 BC056150.1 CR542252.1

CR598341.1 M25269.1

12 DOTS entries:

DT.100785120 DT.100785119 DT.100785117 DT.100771256 DT.102843928 DT.213807 DT.95082760 DT.101959439

DT.121637185 DT.92432597 DT.97842842 DT.100035717

24/164 AceView cDNA sequences (see all 164 ):

CR598341 AI203709 AA655006 BU501322 BE293251 BX388204 AA831352 AA576028

CR542252 BI755351 AW305143 BF116169 BX367275 AL560620 BM699844 BM802647

BE877400 BM713955 BM475656 BX493565 CN478486 AA844141 BC056150 BE645946

highest scoring ESTs for ELK1:

M25269 AA134796 AB016193 AF000672 AL525431 AL556333 BC048296 BE787446 BE883422 BF953438

Unigene Cluster for ELK1:

ELK1, member of ETS oncogene family

Hs.181128 [show with all ESTs]

Unigene Representative Sequence: AB209047

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ELK1 (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	^	8
SP1:							-				-				-
SP2:							-				-				-				-		-		-		-
SP3:							-		-		-				-
SP4:
SP5:							-

About this scheme

ECgene alternative splicing isoforms for ELK1

4 Ensembl transcripts including schematic representations:

ENST00000247161 ENST00000343894 ENST00000376983 ENST00000376985

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ELK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ELK1

¹ / ² / ³

10 probe-sets matching ELK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1781_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.86	M25269	1.00	1.00	1.00	1
33275_at²^{, 3}	U95-A	1	1.00	1.00	0.73	1.15	AB016194	0.20	1.00	0.72	1
203617_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005229	0.60	1.00	0.82	1
210850_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF000672	0.80	1.00	0.91	1
210376_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M25269	1.00	1.00	1.00	1
217039_x_at²	U133-A	1	0.55	1.00	--	--	--	--	--	--	--
203617_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210850_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210376_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217039_x_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

GeneDecks ELK1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATTTTCAGT

SOURCE GeneReport for Unigene cluster: Hs.181128
Expression variation in blood from EXPOLDB for ELK1
UniProtKB/Swiss-Prot: ELK1_HUMAN, P19419
Tissue specificity: Lung and testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ELK1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ELK1¹	--	ELK1, member of ETS oncogene family	89.17(n) 92.06(a)	491860 XM_548979.2 XP_548979.2
cow (Bos taurus)	ELK1¹	--	ELK1, member of ETS oncogene family	88.94(n) 90.89(a)	786886 XM_001254442.1 XP_001254443.1
rat (Rattus norvegicus)	Elk1¹	--	ELK1, member of ETS oncogene family	83.92(n) 86.42(a)	314436 XM_001078496.1 XP_001078496.1
mouse (Mus musculus)	Elk1^{1, 5}	X (6.20 cM)⁵	ELK1, member of ETS oncogene family^{1, 5}	84.54(n)¹ 85.95(a)¹	13712¹ NM_007922.4¹ NP_031948.4¹ AI385733⁵ AK132354⁵ (see all 14)
zebrafish (Danio rerio)	LOC567895¹	--	similar to ELK1, member of ETS oncogene family	56.9(n) 51.9(a)	567895 XM_691202.3 XP_696294.2

About this table Species with no ortholog for ELK1

ENSEMBL Gene Tree for ELK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ELK1 gene

ETS2² GABPA² ETS1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/38 NCBI SNPs in ELK1 are shown (see all 38 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 36)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1059579^1,2	A,C,F	47383344(+)	`CTGCAT/CTGGGG`	2	N/S	mis¹ ese³		4		EA MN NA	434
--	rs1997639^1,2	C,F	47383462(+)	`CAAACC/TGCCTG`	2	G/S	mis¹ ese³		4		NA EA MN	354
--	rs6609542^1,2	C	47395178(+)	`CTGAAA/GAGGCT`	1	--	ng3¹		0	--	--	--	--
	rs2227997^1,2	C,F,H,O	47385644(-)	`TGGGGG/ACTACG`	2	G/G	syn¹		6		MN EU EA WA NA	546
--	rs2227996^1,2	F	47381205(-)	`ACCCCC/TGTGGT`	2	P/P	syn¹ ese³		1		MN	64
	rs2229088^1,2	F	47382508(-)	`CCGCCC/AGAGGC`	2	P/P	syn¹ ese³		1		MN	34
	rs1998837^1,2	A,C,F,H,O	47387809(+)	`tttggC/Tggcaa`	1	--	int¹		12		EU EA WA NA	944
--	rs2283735^1,2	C,F,H	47392685(-)	`TTCTAA/GGAGTG`	1	--	int¹		4		EU EA WA	420
	rs11798941^1,2	C,H	47389991(+)	`CTTCAG/AGCGGA`	1	--	int¹		4		EU EA WA	416
	rs6608736^1,2	F,H	47389194(+)	`CACAAG/CAGGGT`	1	--	int¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for ELK1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 311040

10/13 Novoseek disease relationships for ELK1 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate carcinoma	36.00	1	16369914 (1)
tumors	22.61	6	10514437 (1), 10934204 (1), 11050045 (1), 17203534 (1) (see all 6)
necrosis	11.38	2	10913190 (1), 11520792 (1)
prostate cancer	10.41	1	18712680 (1)
breast cancer	10.06	7	11313879 (2), 9696047 (2), 11773443 (1), 19170108 (1)
choriocarcinoma	4.43	1	15829977 (1)
hyperplasia	0.00	1	11701445 (1)
shock	0.00	2	10969830 (1), 8562482 (1)
cancer	0.00	1	17519035 (1)
inflammation	0.00	1	18752500 (1)

About this table

Human Gene Mutation Database: ELK1
Tumor Gene Database: ELK1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/375 PubMed articles for ELK1 gene (see all 375 ):

elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. (PubMed id 2539641)^{2, 3, 4} Rao V.N....Reddy E.S.P. (1989)
SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. (PubMed id 15210726)^{1, 3, 4} Salinas S.... Hipskind R.A. (2004)
PIASx acts as an Elk-1 coactivator by facilitating derepression. (PubMed id 15920481)^{1, 3, 4} Yang S.-H. and Sharrocks A.D. (2005)
Elk-1 protein domains required for direct and SRF-assisted DNA- binding. (PubMed id 1630903)^{1, 3, 4} Janknecht R. and Nordheim A. (1992)
Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. (PubMed id 12887893)^{1, 3, 4} Yang S.-H.... Sharrocks A.D. (2003)
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. (PubMed id 7889942)^{1, 3, 4} Gille H.... Shaw P.E. (1995)
Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. (PubMed id 10742173)^{1, 3, 4} Mo Y.... Marmorstein R. (2000)
Structural organization of the human Elk1 gene and its processed pseudogene Elk2. (PubMed id 10231026)^{1, 3, 4} Yamauchi T....Isobe M. (1999)
The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus. (PubMed id 9795224)^{1, 3, 4} Harindranath N.... Max E.E. (1998)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2002	HGNC: 3321	AceView: ELK1	Ensembl:ENSG00000126767	euGenes: HUgn2002
ECgene: ELK1	H-InvDB: ELK1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ELK1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ELK1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ELK1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ELK1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Predesigned and custom siRNAs for ELK1		Antibodies for ELK1
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	Lentivirus-delivered shRNAs for ELK1		Browse small molecules at Sigma-Aldrich
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Antibodies & Assays for ELK1 (Elk-1)

	Recombinant Proteins (ELK1)
	Antibodies (ELK1)

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Antibodies for ELK1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ELK1 Gene at Home site.
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ELK1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ELK1

Summaries
for ELK1

Genomic Location
for ELK1

Proteins
for ELK1

Protein Domains/
Families
for ELK1

Gene Function
for ELK1

Pathways & Interactions
for ELK1

Drugs & Compounds
for ELK1

Transcripts
for ELK1

Expression
for ELK1

Orthologs
for ELK1

Paralogs
for ELK1

SNPs/Variants
for ELK1

Disorders & Mutations
for ELK1

Medical News
for ELK1

Publications
for ELK1

Search for ELK1

Genome Databases showing ELK1

Other Databases showing ELK1

Specialized Databases showing ELK1

Licensable Technologies
for ELK1

Services
for ELK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ELK1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ELK1

Summariesfor ELK1

Genomic Locationfor ELK1

Proteinsfor ELK1

Protein Domains/Familiesfor ELK1

Gene Functionfor ELK1

Pathways & Interactionsfor ELK1

Drugs & Compoundsfor ELK1

Transcriptsfor ELK1

Expression for ELK1

Orthologsfor ELK1

Paralogsfor ELK1

SNPs/Variantsfor ELK1

Disorders & Mutationsfor ELK1

Medical Newsfor ELK1

Publicationsfor ELK1

Search for ELK1

Genome Databases showing ELK1

Other Databases showing ELK1

Specialized Databases showing ELK1

Licensable Technologiesfor ELK1

Servicesfor ELK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ELK1

Summaries
for ELK1

Genomic Location
for ELK1

Proteins
for ELK1

Protein Domains/
Families
for ELK1

Gene Function
for ELK1

Pathways & Interactions
for ELK1

Drugs & Compounds
for ELK1

Transcripts
for ELK1

Expression
for ELK1

Orthologs
for ELK1

Paralogs
for ELK1

SNPs/Variants
for ELK1

Disorders & Mutations
for ELK1

Medical News
for ELK1

Publications
for ELK1

Licensable Technologies
for ELK1

Services
for ELK1