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ELF5 Gene

protein-coding   GIFtS: 58
GCID: GC11M034500

E74-Like Factor 5 (Ets Domain Transcription Factor)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E74-Like Factor 5 (Ets Domain Transcription Factor)1 2     ETS-Related Transcription Factor Elf-52
ESE22 3 5     ESE-23
Epithelium-Restricted ESE-1-Related Ets Factor2 3     E74-Like Factor 53
Epithelium-Specific Ets Transcription Factor 22 3     

External Ids:    HGNC: 33201   Entrez Gene: 20012   Ensembl: ENSG000001353747   OMIM: 6051695   UniProtKB: Q9UKW63   

Export aliases for ELF5 gene to outside databases

Previous GC identifers: GC11M036053 GC11M035178 GC11M034539 GC11M034464 GC11M034456 GC11M034197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELF5 Gene:
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor
family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it
appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such
as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the
amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described
for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for ELF5 Gene:
ELF5 (E74-like factor 5 (ets domain transcription factor)) is a protein-coding gene. Diseases associated with ELF5 include down syndrome, and prostatitis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ELF5_HUMAN, Q9UKW6
Function: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes
terminal differentiation
Function: Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT].
Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters

Gene Wiki entry for ELF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELF5 gene promoter:
         CREB   deltaCREB   c-Myb   TGIF   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELF5 promoter sequence
   Search Chromatin IP Primers for ELF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13-p12   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13-p12

ELF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELF5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M034500:  view genomic region     (about GC identifiers)

Start:
34,500,340 bp from pter      End:
34,535,352 bp from pter
Size:
35,013 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ELF5_HUMAN, Q9UKW6 (See protein sequence)
Recommended Name: ETS-related transcription factor Elf-5  
Size: 265 amino acids; 31263 Da
1 PDB 3D structure from and Proteopedia for ELF5:
1WWX (3D)    
Secondary accessions: A8K452 O95175 Q8N2K9 Q96QY3 Q9UKW5
Alternative splicing: 3 isoforms:  Q9UKW6-1   Q9UKW6-2   Q9UKW6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ELF5: NX_Q9UKW6

Explore proteomics data for ELF5 at MOPED


See ELF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001230009.1  NP_001230010.1  NP_001413.1  NP_938195.1  

ENSEMBL proteins: 
 ENSP00000257832   ENSP00000311010   ENSP00000407589   ENSP00000436386  

ELF5 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR003118 Pointed_dom
 IPR013761 SAM/pointed
 IPR000418 Ets_dom

Graphical View of Domain Structure for InterPro Entry Q9UKW6

ProtoNet protein and cluster: Q9UKW6

1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

UniProtKB/Swiss-Prot: ELF5_HUMAN, Q9UKW6
Domain: The PNT domain acts as a transcriptional activator (By similarity)
Similarity: Belongs to the ETS family
Similarity: Contains 1 ETS DNA-binding domain
Similarity: Contains 1 PNT (pointed) domain


ELF5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ELF5_HUMAN, Q9UKW6
Function: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes
terminal differentiation
Function: Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT].
Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters

     Genatlas biochemistry entry for ELF5:
E74-like factor 5,ETS transcription factor family,expressed in differentiated keratinocytes and glandular
epithelium,lung,stomach,kidney,prostate,bladder,mammary gland,putative regulator of epithelial cell
differentiation,not expressed in hematopoietic compartiments,possibly involved in humorigenesis

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
GO:0003700sequence-specific DNA binding transcription factor activity ----
GO:0043565sequence-specific DNA binding IEA--
     
ELF5 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for ELF5:
 Increased cell death HMECs cel 

     6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Elf5):
 embryogenesis  endocrine/exocrine gland  growth/size/body  integument  mortality/aging 
 reproductive system 

ELF5 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for ELF5: Elf5tm1Mapr Elf5tm1Plp

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELF5
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELF5

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELF5
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELF5

Transcription Factor Targeting: 
Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                      Consensus sequence:  ACVAGGAAGT 

miRNA
Products:
    
miRTarBase miRNAs that target ELF5:
hsa-mir-5787 (MIRT006662)

Block miRNA regulation of human, mouse, rat ELF5 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ELF5 (see all 24):
hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-148b hsa-miR-539 hsa-miR-570 hsa-miR-374a* hsa-miR-223 hsa-miR-144
SwitchGear 3'UTR luciferase reporter plasmidELF5 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for ELF5
Predesigned siRNA for gene silencing in human, mouse, rat ELF5

Gene Editing
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DNA2.0 Custom Protein Engineering Service for ELF5

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GenScript: all cDNA clones in your preferred vector (see all 2): ELF5 (NM_001422)
Sino Biological Human cDNA Clone for ELF5
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELF5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF5

Cell Line
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GenScript Custom overexpressing Cell Line Services for ELF5
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF5


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ELF5_HUMAN, Q9UKW6: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2
cytosol1
extracellular1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IBA--
GO:0005737cytoplasm IEA--

ELF5 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ELF5 About    
See pathways by source

SuperPathContained pathways About
1Prolactin Signaling Pathway
Prolactin signaling pathway0.33

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




1 Kegg Pathway  (Kegg details for ELF5):
    Prolactin signaling pathway


ELF5 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELF5
Interactions:

    GeneGlobe Interaction Network for ELF5

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for ELF5 (Q9UKW62, 3 ENSP000003110104) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
InteractantInteraction Details
GeneCardExternal ID(s)
RPS15AP622442, 3, ENSP000003186464MINT-67543 I2D: score=5 STRING: ENSP00000318646
SIRT6Q8N6T72, 3, ENSP000003373324MINT-67097 I2D: score=4 STRING: ENSP00000337332
FRZBQ927652, 3, ENSP000002951134MINT-8255470 I2D: score=2 STRING: ENSP00000295113
UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2858473 I2D: score=3 STRING: ENSP00000357292
SS18L1O751773, ENSP000003330124I2D: score=1 STRING: ENSP00000333012
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated ----
GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
GO:0006366transcription from RNA polymerase II promoter TAS9840936
GO:0007398ectoderm development IEA--
GO:0008283cell proliferation TAS9840936

ELF5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ELF5



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ELF5 gene (4 alternative transcripts): 
NM_001243080.1  NM_001243081.1  NM_001422.3  NM_198381.1  

Unigene Cluster for ELF5:

E74-like factor 5 (ets domain transcription factor)
Hs.11713  [show with all ESTs]
Unigene Representative Sequence: NM_198381
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000257832(uc001mvp.2 uc009ykd.2) ENST00000312319(uc001mvo.1 uc021qft.1)
ENST00000429939 ENST00000528709 ENST00000532417(uc001mvq.2)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat ELF5 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ELF5 (see all 24):
hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-148b hsa-miR-539 hsa-miR-570 hsa-miR-374a* hsa-miR-223 hsa-miR-144
SwitchGear 3'UTR luciferase reporter plasmidELF5 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ELF5
Predesigned siRNA for gene silencing in human, mouse, rat ELF5
Clone
Products:
     
OriGene clones in human, mouse for ELF5 (see all 12)
OriGene ORF clones in mouse, rat for ELF5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): ELF5 (NM_001422)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELF5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF5
Primer
Products:
    
OriGene qPCR primer pairs and template standards for ELF5
OriGene qSTAR qPCR primer pairs in human, mouse for ELF5
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELF5
  QuantiTect SYBR Green Assays in human, mouse, rat ELF5
  QuantiFast Probe-based Assays in human, mouse, rat ELF5

Additional mRNA sequence: 

AF049703.1 AF115402.1 AF115403.1 AK075197.1 AK290808.1 AK290817.1 AK312537.1 BC029743.1 
DQ123839.1 

4 DOTS entries:

DT.95154581  DT.110132  DT.91912824  DT.120693381 

Selected AceView cDNA sequences (see all 60):

BP358543 BG260616 BX642191 CK430112 BP358329 BF002858 AF049703 BP358325 
BM832390 AI279543 AK075197 CK430123 AI279525 BM831565 BV188571 AW118829 
AI284295 NM_001422 BM822600 AF115402 AF115403 AK074633 AA055924 BM831491 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ELF5    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1:              -     -                 -                           
SP2:                                      -                           
SP3:                                -     -                           
SP4:              -     -                                             


ECgene alternative splicing isoforms for ELF5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ELF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTTTTCCAG
ELF5 Expression
About this image


ELF5 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Kidney (Urinary System)    fully expand to see all 4 entries
         Ureteric Bud Cells Ureteric Bud
         Renal Collecting Duct System
 
 Trophoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
         Trophoblast Cells Trophoblast
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Myoblasts Mandibular Arch Muscles
 
 Zygote (Early Embryonic Tissues)
         Morula Cells Morula
 
 Inner Cell Mass (Early Embryo)
         Morula Cells Morula
ELF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ELF5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.11713

UniProtKB/Swiss-Prot: ELF5_HUMAN, Q9UKW6
Tissue specificity: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in
salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform
2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate
expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte
differentiation. Several epithelial carcinoma cell lines showed lack of expression

    Custom PCR Arrays for ELF5
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QuantiTect SYBR Green Assays in human, mouse, rat ELF5
QuantiFast Probe-based Assays in human, mouse, rat ELF5
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ELF5 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Elf55 E74-like factor 5   --   2 (54.43 cM) 103411713 
chicken
(Gallus gallus)
Aves ELF51 E74-like factor 5 (ets domain transcription factor) 77.43(n)
78.21(a)
  428859  XM_004941538.1  XP_004941595.1 
lizard
(Anolis carolinensis)
Reptilia ELF56
E74-like factor 5 (ets domain transcription factor...
72(a)
1 ↔ 1
GL343283.1(1547910-1557700)
tropical clawed frog
(Xenopus tropicalis)
Amphibia elf51 E74-like factor 5 (ets domain transcription factor) 64.24(n)
60.73(a)
  100494059  XM_004913344.1  XP_004913401.1 
fruit fly
(Drosophila melanogaster)
Insecta aop6
anterior open
9(a)
1 → many
2L(2156484-2178749)
worm
(Caenorhabditis elegans)
Secernentea tag-976
Protein TAG-97, isoform a
16(a)
1 → many
X(15369998-15377685) WBGene00006462


ENSEMBL Gene Tree for ELF5 (if available)
TreeFam Gene Tree for ELF5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ELF5 gene
ELK42  ELF32  ELF42  ELF12  ETV72  ELK12  ETV62  EHF2  
ELF22  SPDEF2  ELK32  
15 SIMAP similar genes for ELF5 using alignment to 3 protein entries:     ELF5_HUMAN (see all proteins):
ELF3    ELF4    ELK3    ELK4    ETV6    ELF1
ELK1    ETV7    ETV3    ELF2    ETV3L    EHF
SPDEF    SPIC    ETV1

ELF5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ELF5 (see all 888)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs722823051,2
C--34231520(+) GGGGA-/T/TT  
        
TTTTT
4 -- us2k1 int10--------
rs110327161,2
C,F--34428536(+) TTTCGA/TTTTCT 4 -- ds50016Minor allele frequency- T:0.16NA WA EA 364
rs1923681651,2
--34428558(+) TGAAGA/TAACAG 4 -- ds50010--------
rs1434505851,2
--34428641(+) TGTGCA/GTCAAT 4 -- ds50010--------
rs15357211,2
C,F,A,H--34428741(-) ATTTTC/TAAAGA 4 -- ds500137Minor allele frequency- T:0.48EA NS NA WA CSA 3277
rs725564021,2
C,F--34428993(-) TGTCTG/ATGTAT 4 -- ds50012Minor allele frequency- A:0.02WA 210
rs1471661081,2
C--34429025(+) ATTCAC/TATTGT 4 -- ut310--------
rs15357201,2
C,H--34429093(-) AAAATG/ATGAAT 4 -- ut3115Minor allele frequency- A:0.09MN NA WA CSA EA 656
rs725564011,2
C,F--34429137(-) AAGACC/TTCCTT 4 -- ut312Minor allele frequency- T:0.02EA 204
rs725564001,2
C,F--34429212(-) GTGGAC/TTGCCC 4 -- ut312Minor allele frequency- T:0.04WA 204

HapMap Linkage Disequilibrium report for ELF5 (34500340 - 34535352 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for ELF5:    About this table    
Variant IDTypeSubtypePubMed ID
esv2667974CNV Deletion23128226
dgv1069n71CNV Gain21882294
nsv832114CNV Gain17160897
dgv1070n71CNV Gain21882294
dgv1068n71CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605169    OMIM disorders: --

13 diseases for ELF5:    
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down syndrome    prostatitis    lateral sclerosis    amyotrophic lateral sclerosis
asthma    ataxia    retinitis    cervicitis
thyroiditis    prostate cancer    breast cancer    neuronitis
endotheliitis


ELF5 for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for ELF5 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome 37.2 2 17168651 (1), 17559337 (1)
carcinoma 0 4 9840936 (3)

Genetic Association Database (GAD): ELF5
Human Genome Epidemiology (HuGE) Navigator: ELF5 (1 document)

Export disorders for ELF5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ELF5 gene, integrated from 10 sources (see all 49):
(articles sorted by number of sources associating them with ELF5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. (PubMed id 9840936)1, 2, 3, 9 Zhou J....Kola I. (Oncogene 1998)
  2. Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. (PubMed id 10506207)1, 2, 9 Oettgen P....Libermann T.A. (J. Biol. Chem. 1999)
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma. (PubMed id 12359648)1, 4 Baron R.M....Silverman E.S. (Am. J. Respir. Crit. Care Med. 2002)
  7. Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1. (PubMed id 15987600)1, 9 Yaniw D. and Hu J. (Cell Res. 2005)
  8. Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor. (PubMed id 16229011)1, 9 Tummala R. and Sinha S. (J. Cell. Biochem. 2006)
  9. Genetic determinants of plasma I^a88-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. (PubMed id 23279374)1 Athanasiadis G....Soria J.M. (J. Thromb. Haemost. 2013)
  10. Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. (PubMed id 23086238)1 Chakrabarti R....Kang Y. (Nat. Cell Biol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2001 HGNC: 3320 AceView: ELF5 Ensembl:ENSG00000135374 euGenes: HUgn2001
ECgene: ELF5 Kegg: 2001 H-InvDB: ELF5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ELF5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ELF5 gene:
Search GeneIP for patents involving ELF5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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