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Aliases for ELF5 Gene

Aliases for ELF5 Gene

  • E74 Like ETS Transcription Factor 5 2 3
  • E74-Like Factor 5 (Ets Domain Transcription Factor) 2 3 5
  • Epithelium-Restricted ESE-1-Related Ets Factor 3 4
  • Epithelium-Specific Ets Transcription Factor 2 3 4
  • ESE2 3 4
  • E74-Like Factor 5 4
  • ESE-2 4

External Ids for ELF5 Gene

Previous GeneCards Identifiers for ELF5 Gene

  • GC11M036053
  • GC11M035178
  • GC11M034539
  • GC11M034464
  • GC11M034456
  • GC11M034197

Summaries for ELF5 Gene

Entrez Gene Summary for ELF5 Gene

  • The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for ELF5 Gene

ELF5 (E74 Like ETS Transcription Factor 5) is a Protein Coding gene. Among its related pathways are Prolactin Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELF5 Gene

  • Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.

  • Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.

Gene Wiki entry for ELF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF5 Gene

Genomics for ELF5 Gene

Regulatory Elements for ELF5 Gene

Genomic Location for ELF5 Gene

Chromosome:
11
Start:
34,478,793 bp from pter
End:
34,513,805 bp from pter
Size:
35,013 bases
Orientation:
Minus strand

Genomic View for ELF5 Gene

Genes around ELF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF5 Gene

Proteins for ELF5 Gene

  • Protein details for ELF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKW6-ELF5_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-5
    Protein Accession:
    Q9UKW6
    Secondary Accessions:
    • A6XAE6
    • A8K452
    • O95175
    • Q8N2K9
    • Q96QY3
    • Q9UKW5

    Protein attributes for ELF5 Gene

    Size:
    265 amino acids
    Molecular mass:
    31263 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ELF5 Gene

    Alternative splice isoforms for ELF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELF5 Gene

Proteomics data for ELF5 Gene at MOPED

Post-translational modifications for ELF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELF5 Gene

No data available for DME Specific Peptides for ELF5 Gene

Domains & Families for ELF5 Gene

Gene Families for ELF5 Gene

Protein Domains for ELF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKW6

UniProtKB/Swiss-Prot:

ELF5_HUMAN :
  • The PNT domain acts as a transcriptional activator.
  • Belongs to the ETS family.
Domain:
  • The PNT domain acts as a transcriptional activator.
  • Contains 1 ETS DNA-binding domain.
  • Contains 1 PNT (pointed) domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELF5: view

Function for ELF5 Gene

Molecular function for ELF5 Gene

GENATLAS Biochemistry:
E74-like factor 5,ETS transcription factor family,expressed in differentiated keratinocytes and glandular epithelium,lung,stomach,kidney,prostate,bladder,mammary gland,putative regulator of epithelial cell differentiation,not expressed in hematopoietic compartiments,possibly involved in humorigenesis
UniProtKB/Swiss-Prot Function:
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.
UniProtKB/Swiss-Prot Function:
Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
genes like me logo Genes that share phenotypes with ELF5: view

Animal Model Products

Targeted motifs for ELF5 Gene
HOMER Transcription Factor Regulatory Elements motif ELF5
  • Consensus sequence: ACVAGGAAGT Submotif: canonical Cell Type: T47D GEO ID: GSE30407

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ELF5 Gene

Localization for ELF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELF5 Gene COMPARTMENTS Subcellular localization image for ELF5 gene
Compartment Confidence
nucleus 4
cytosol 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ELF5 Gene

Pathways & Interactions for ELF5 Gene

SuperPathways for ELF5 Gene

Superpath Contained pathways
1 Prolactin Signaling Pathway
genes like me logo Genes that share pathways with ELF5: view

Pathways by source for ELF5 Gene

1 KEGG pathway for ELF5 Gene

Gene Ontology (GO) - Biological Process for ELF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0030154 cell differentiation IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0060644 mammary gland epithelial cell differentiation IEA --
genes like me logo Genes that share ontologies with ELF5: view

No data available for SIGNOR curated interactions for ELF5 Gene

Drugs & Compounds for ELF5 Gene

No Compound Related Data Available

Transcripts for ELF5 Gene

Unigene Clusters for ELF5 Gene

E74-like factor 5 (ets domain transcription factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELF5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for ELF5 Gene

GeneLoc Exon Structure for
ELF5
ECgene alternative splicing isoforms for
ELF5

Expression for ELF5 Gene

mRNA expression in normal human tissues for ELF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELF5 Gene

This gene is overexpressed in Minor Salivary Gland (x19.4), Breast - Mammary Tissue (x13.0), and Bladder (x4.5).

SOURCE GeneReport for Unigene cluster for ELF5 Gene Hs.11713

mRNA Expression by UniProt/SwissProt for ELF5 Gene

Q9UKW6-ELF5_HUMAN
Tissue specificity: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression.
genes like me logo Genes that share expression patterns with ELF5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ELF5 Gene

Orthologs for ELF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELF5 35
  • 99.62 (n)
  • 99.25 (a)
ELF5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELF5 36
  • 95 (a)
OneToOne
ELF5 35
  • 91.9 (n)
  • 94.9 (a)
dog
(Canis familiaris)
Mammalia ELF5 35
  • 89.65 (n)
  • 93.56 (a)
ELF5 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elf5 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELF5 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELF5 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910896 35
  • 100 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves ELF5 35
  • 77.43 (n)
  • 78.21 (a)
ELF5 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELF5 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elf5 35
  • 64.24 (n)
  • 60.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta aop 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-97 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 9 (a)
OneToMany
Species with no ortholog for ELF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ELF5 Gene

ENSEMBL:
Gene Tree for ELF5 (if available)
TreeFam:
Gene Tree for ELF5 (if available)

Paralogs for ELF5 Gene

Paralogs for ELF5 Gene

(15) SIMAP similar genes for ELF5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ELF5: view

Variants for ELF5 Gene

Sequence variations from dbSNP and Humsavar for ELF5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10312 -- 34,478,806(+) TAAAT(A/G)CTTTA utr-variant-3-prime
rs942222 -- 34,489,568(-) TAAGA(A/C/T)GATGG intron-variant
rs737254 -- 34,493,394(-) TGTGA(A/C/G/T)TTGCA intron-variant
rs836144 -- 34,513,110(-) GTTAG(C/G)GTTTT intron-variant, upstream-variant-2KB
rs1323690 -- 34,479,140(-) TCAAG(A/C/G/T)GCTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ELF5 Gene

Variant ID Type Subtype PubMed ID
dgv1068n71 CNV Gain 21882294
dgv1069n71 CNV Gain 21882294
nsv832114 CNV Gain 17160897
esv2667974 CNV Deletion 23128226
dgv1070n71 CNV Gain 21882294

Variation tolerance for ELF5 Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELF5 Gene

HapMap Linkage Disequilibrium report
ELF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELF5 Gene

Disorders for ELF5 Gene

Relevant External Links for ELF5

Genetic Association Database (GAD)
ELF5
Human Genome Epidemiology (HuGE) Navigator
ELF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELF5

No disorders were found for ELF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELF5 Gene

Publications for ELF5 Gene

  1. A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. (PMID: 9840936) Zhou J. … Kola I. (Oncogene 1998) 2 3 4 23 67
  2. Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor. (PMID: 16229011) Tummala R. … Sinha S. (J. Cell. Biochem. 2006) 3 23
  3. Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1. (PMID: 15987600) Yaniw D. … Hu J. (Cell Res. 2005) 3 23
  4. Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. (PMID: 10506207) Oettgen P. … Libermann T.A. (J. Biol. Chem. 1999) 3 23
  5. Elf5 inhibits TGF-I^-driven epithelial-mesenchymal transition in prostate cancer by repressing SMAD3 activation. (PMID: 25728398) Yao B. … Xu Y. (Prostate 2015) 3

Products for ELF5 Gene

Sources for ELF5 Gene

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