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Aliases for ELF4 Gene

Aliases for ELF4 Gene

  • E74-Like Factor 4 (Ets Domain Transcription Factor) 2 3
  • MEF 3 4 6
  • Myeloid Elf-1-Like Factor 3 4
  • ELFR 3 4
  • ETS-Related Transcription Factor Elf-4 3
  • E74-Like Factor 4 4

External Ids for ELF4 Gene

Previous GeneCards Identifiers for ELF4 Gene

  • GC0XM123844
  • GC0XM126044
  • GC0XM127143
  • GC0XM127904
  • GC0XM127885
  • GC0XM128924
  • GC0XM129026
  • GC0XM129198
  • GC0XM118596

Summaries for ELF4 Gene

Entrez Gene Summary for ELF4 Gene

  • The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

GeneCards Summary for ELF4 Gene

ELF4 (E74-Like Factor 4 (Ets Domain Transcription Factor)) is a Protein Coding gene. Diseases associated with ELF4 include agammaglobulinemia and isolated hormone deficiency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ELF3.

UniProtKB/Swiss-Prot for ELF4 Gene

  • Transcriptional activator that binds to DNA sequences containing the consensus 5-WGGA-3. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.

Gene Wiki entry for ELF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF4 Gene

Genomics for ELF4 Gene

Regulatory Elements for ELF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ELF4 Gene

Start:
130,064,874 bp from pter
End:
130,110,716 bp from pter
Size:
45,843 bases
Orientation:
Minus strand

Genomic View for ELF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF4 Gene

Proteins for ELF4 Gene

  • Protein details for ELF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99607-ELF4_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-4
    Protein Accession:
    Q99607
    Secondary Accessions:
    • D3DTG1
    • O60435

    Protein attributes for ELF4 Gene

    Size:
    663 amino acids
    Molecular mass:
    70730 Da
    Quaternary structure:
    • Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.
    SequenceCaution:
    • Sequence=AAC17452.1; Type=Frameshift; Positions=334, 412; Evidence={ECO:0000305};

neXtProt entry for ELF4 Gene

Proteomics data for ELF4 Gene at MOPED

Post-translational modifications for ELF4 Gene

  • Ubiquitination at Lys257 and Lys291
  • Modification sites at PhosphoSitePlus

Other Protein References for ELF4 Gene

No data available for DME Specific Peptides for ELF4 Gene

Domains for ELF4 Gene

Protein Domains for ELF4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99607

UniProtKB/Swiss-Prot:

ELF4_HUMAN :
  • Q99607
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELF4: view

No data available for Gene Families for ELF4 Gene

Function for ELF4 Gene

Molecular function for ELF4 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator that binds to DNA sequences containing the consensus 5-WGGA-3. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
UniProtKB/Swiss-Prot Induction: By ponisterone A in erythroleukemia cells.

Gene Ontology (GO) - Molecular Function for ELF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 14625302
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 14625302
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 10207087
genes like me logo Genes that share ontologies with ELF4: view

Phenotypes for ELF4 Gene

genes like me logo Genes that share phenotypes with ELF4: view

Animal Models for ELF4 Gene

MGI Knock Outs for ELF4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ELF4 Gene

Localization for ELF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF4 Gene

Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELF4 Gene COMPARTMENTS Subcellular localization image for ELF4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ELF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0016605 PML body IDA 14970218
genes like me logo Genes that share ontologies with ELF4: view

Pathways for ELF4 Gene

SuperPathways for ELF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001787 natural killer cell proliferation ISS --
GO:0001866 NK T cell proliferation ISS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with ELF4: view

No data available for Pathways by source for ELF4 Gene

Compounds for ELF4 Gene

(1) Novoseek inferred chemical compound relationships for ELF4 Gene

Compound -log(P) Hits PubMed IDs
agar 28.3 1
genes like me logo Genes that share compounds with ELF4: view

Transcripts for ELF4 Gene

Unigene Clusters for ELF4 Gene

E74-like factor 4 (ets domain transcription factor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELF4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELF4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2:
SP3: - - -
SP4:

Relevant External Links for ELF4 Gene

GeneLoc Exon Structure for
ELF4
ECgene alternative splicing isoforms for
ELF4

Expression for ELF4 Gene

mRNA expression in normal human tissues for ELF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELF4 Gene

This gene is overexpressed in Whole Blood (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELF4 Gene

SOURCE GeneReport for Unigene cluster for ELF4 Gene Hs.271940

mRNA Expression by UniProt/SwissProt for ELF4 Gene

Q99607-ELF4_HUMAN
Tissue specificity: Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.
genes like me logo Genes that share expressions with ELF4: view

In Situ Assay Products

Orthologs for ELF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELF4 35
  • 88.27 (n)
  • 88.07 (a)
ELF4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELF4 35
  • 89.46 (n)
  • 89.56 (a)
ELF4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elf4 35
  • 83.21 (n)
  • 79.08 (a)
Elf4 16
Elf4 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ELF4 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elf4 35
  • 83.84 (n)
  • 79.24 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ef1 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip74EF 37
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea elf-1 36
  • 26 (a)
ManyToMany
ets-8 36
  • 34 (a)
ManyToMany
C24A1.2 37
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for ELF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ELF4 Gene

ENSEMBL:
Gene Tree for ELF4 (if available)
TreeFam:
Gene Tree for ELF4 (if available)

Paralogs for ELF4 Gene

Paralogs for ELF4 Gene

Selected SIMAP similar genes for ELF4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ELF4: view

Variants for ELF4 Gene

Sequence variations from dbSNP and Humsavar for ELF4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs209990 -- 130,098,416(-) CTGCC(C/T)GGACT intron-variant
rs209991 -- 130,098,098(-) GCTCC(A/G)GGCTG intron-variant
rs209992 -- 130,096,340(-) CCGGT(A/G)TGGCT intron-variant
rs209993 -- 130,096,007(-) GCTTA(C/G)TGGGA intron-variant
rs209994 -- 130,093,478(+) GACTT(A/C)CACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELF4 Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV Gain 19592680
nsv7090 CNV Loss 18451855
esv1493190 CNV Deletion 17803354
esv25673 CNV Loss 19812545

Relevant External Links for ELF4 Gene

HapMap Linkage Disequilibrium report
ELF4
Human Gene Mutation Database (HGMD)
ELF4
Locus Specific Mutation Databases (LSDB)
ELF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELF4 Gene

Disorders for ELF4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ELF4 Gene including...

Search for ELF4 Gene in MalaCards »

UniProtKB/Swiss-Prot

ELF4_HUMAN
  • Note=A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.

(3) Novoseek inferred disease relationships for ELF4 Gene

Disease -log(P) Hits PubMed IDs
promyelocytic leukemia 58.1 2
tumors 0 4
cancer 0 1
genes like me logo Genes that share disorders with ELF4: view

Publications for ELF4 Gene

  1. MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties. (PMID: 8895518) Miyazaki Y. … Nimer S. (Oncogene 1996) 2 3 4 23
  2. Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein. (PMID: 14976184) Suico M.A. … Kai H. (J. Biol. Chem. 2004) 3 4 23
  3. MEF up-regulates human beta-defensin 2 expression in epithelial cells. (PMID: 15013761) Lu Z. … Kai H. (FEBS Lett. 2004) 3 23
  4. Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells. (PMID: 15907486) Koga T. … Kai H. (FEBS Lett. 2005) 3 23
  5. The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. (PMID: 16581786) Liu Y. … Nimer S.D. (Mol. Cell. Biol. 2006) 3 23

Products for ELF4 Gene

Sources for ELF4 Gene

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