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ELF4 Gene

protein-coding   GIFtS: 53
GCID: GC0XM129198

E74-Like Factor 4 (Ets Domain Transcription Factor)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E74-Like Factor 4 (Ets Domain Transcription Factor)1 2
MEF2 3 5
Myeloid Elf-1-Like Factor2 3
ELFR2 3
ETS-Related Transcription Factor Elf-42
E74-Like Factor 43

External Ids:    HGNC: 33191   Entrez Gene: 20002   Ensembl: ENSG000001020347   OMIM: 3007755   UniProtKB: Q996073   

Export aliases for ELF4 gene to outside databases

Previous GC identifers: GC0XM123844 GC0XM126044 GC0XM127143 GC0XM127904 GC0XM127885 GC0XM128924 GC0XM129026 GC0XM118596


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELF4 Gene:
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the
CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function,
innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the
same protein have been found for this gene.(provided by RefSeq, Jan 2010)

GeneCards Summary for ELF4 Gene:
ELF4 (E74-like factor 4 (ets domain transcription factor)) is a protein-coding gene. Diseases associated with ELF4 include agammaglobulinemia and isolated hormone deficiency, and dental caries. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ELF4_HUMAN, Q99607
Function: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'.
Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme
gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the
PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and
in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and
KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular
transformation through inhibition of the p16 pathway

Gene Wiki entry for ELF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELF4 gene promoter:
         Max   RORalpha1   USF1   USF-1   POU6F1 (c2)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELF4 promoter sequence
   Search Chromatin IP Primers for ELF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq26

ELF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELF4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM129198:  view genomic region     (about GC identifiers)

Start:
129,198,849 bp from pter      End:
129,244,691 bp from pter
Size:
45,843 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ELF4_HUMAN, Q99607 (See protein sequence)
Recommended Name: ETS-related transcription factor Elf-4  
Size: 663 amino acids; 70730 Da
Subunit: Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts
(via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances
transactivation of LYZ
Sequence caution: Sequence=AAC17452.1; Type=Frameshift; Positions=334, 412;
Secondary accessions: D3DTG1 O60435

Explore the universe of human proteins at neXtProt for ELF4: NX_Q99607

Explore proteomics data for ELF4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys257, Lys291
  • Modification sites at PhosphoSitePlus

  • See ELF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120669.1  NP_001412.1  

    ENSEMBL proteins: 
     ENSP00000338608   ENSP00000311280   ENSP00000407572  

    ELF4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000418 Ets_dom
     IPR022084 TF_Elf_N

    Graphical View of Domain Structure for InterPro Entry Q99607

    ProtoNet protein and cluster: Q99607

    UniProtKB/Swiss-Prot: ELF4_HUMAN, Q99607
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ELF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELF4_HUMAN, Q99607
    Function: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'.
    Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme
    gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the
    PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and
    in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and
    KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular
    transformation through inhibition of the p16 pathway
    Induction: By ponisterone A in erythroleukemia cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding IPI10207087
    GO:0043565sequence-specific DNA binding IEA--
         
    ELF4 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Elf4):
     hematopoietic system  immune system 

    ELF4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Elf4tm1Nim for ELF4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELF4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELF4

    miRNA
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    miRTarBase miRNAs that target ELF4:
    hsa-mir-505-3p (MIRT041006), hsa-mir-92a-3p (MIRT049601), hsa-mir-25-3p (MIRT050308), hsa-mir-26b-5p (MIRT029730), hsa-mir-877-5p (MIRT037325), hsa-mir-615-3p (MIRT039637), hsa-mir-124-3p (MIRT002580)

    Block miRNA regulation of human, mouse, rat ELF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELF4 (see all 22):
    hsa-miR-1226 hsa-let-7d hsa-let-7c hsa-miR-1285 hsa-miR-4267 hsa-let-7g hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidELF4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ELF4

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    GenScript: all cDNA clones in your preferred vector (see all 2): ELF4 (NM_001421)
    Sino Biological Human cDNA Clone for ELF4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELF4_HUMAN, Q99607: Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016605PML body IDA14970218

    ELF4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELF4
    Interactions:

        GeneGlobe Interaction Network for ELF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ELF4 (Q996073 ENSP000003112804) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP2Q133093, ENSP000002742554I2D: score=3 STRING: ENSP00000274255
    FBXO7Q9Y3I13, ENSP000002660874I2D: score=2 STRING: ENSP00000266087
    UBBP0CG473, ENSP000003046974I2D: score=2 STRING: ENSP00000304697
    FBXO4Q9UKT53, ENSP000002816234I2D: score=1 STRING: ENSP00000281623
    PMLP295903, ENSP000002680584I2D: score=1 STRING: ENSP00000268058
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001787natural killer cell proliferation ISS--
    GO:0001866NK T cell proliferation ISS--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IBA--

    ELF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELF4

    1 Novoseek inferred chemical compound relationship for ELF4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agar 28.3 1 17213815 (1)



    ELF4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ELF4 gene (2 alternative transcripts): 
    NM_001127197.1  NM_001421.3  

    Unigene Cluster for ELF4:

    E74-like factor 4 (ets domain transcription factor)
    Hs.271940  [show with all ESTs]
    Unigene Representative Sequence: NM_001421
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335997(uc004eve.4) ENST00000308167(uc004evd.4) ENST00000434609

    miRNA
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    Block miRNA regulation of human, mouse, rat ELF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELF4 (see all 22):
    hsa-miR-1226 hsa-let-7d hsa-let-7c hsa-miR-1285 hsa-miR-4267 hsa-let-7g hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidELF4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ELF4
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    GenScript: all cDNA clones in your preferred vector (see all 2): ELF4 (NM_001421)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF4
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      QuantiTect SYBR Green Assays in human, mouse, rat ELF4
      QuantiFast Probe-based Assays in human, mouse, rat ELF4

    Additional mRNA sequence: 

    AF000670.1 AK314972.1 BC017194.2 BC114355.1 BC114356.1 U32645.1 

    7 DOTS entries:

    DT.100782422  DT.114252  DT.100782423  DT.92072049  DT.100691235  DT.100666498  DT.95142872 

    Selected AceView cDNA sequences (see all 146):

    BQ065494 BQ049888 CD370476 BM781570 AI382735 AW503592 AL541157 BQ058019 
    AW664603 AI707524 AI926320 BX438675 BF058677 AI678327 AW337816 BF921755 
    CD364651 BX112896 BC017194 BQ684033 BG682239 BU557163 BF056399 AI343390 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ELF4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:        -     -                                                                           
    SP2:                                                                                          
    SP3:                    -     -     -                                                         
    SP4:                                                                                          


    ECgene alternative splicing isoforms for ELF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCTGCTG
    ELF4 Expression
    About this image


    ELF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Brain (Nervous System)
             Hypothalamus
     
     Lymph (Hematopoietic System)
    ELF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271940

    UniProtKB/Swiss-Prot: ELF4_HUMAN, Q99607
    Tissue specificity: Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate
    levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels
    of expression in Jurkat T-cells and other T-cell lines and no expression in brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELF4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elf41 , 5 E74-like factor 4 (ets domain transcription factor)1, 5 83.21(n)1
    79.08(a)1
      X (25.67 cM)5
    565011  NM_019680.21  NP_062654.21 
     484110465 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131159.12   -- 80.88(n)   30396  NM_131159.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C24A1.23   -- 72(a)   III(706423-715521)   --


    ENSEMBL Gene Tree for ELF4 (if available)
    TreeFam Gene Tree for ELF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELF4 gene
    ELK42  ELF32  ELF12  ELF52  ETV72  ELK12  ETV62  EHF2  
    ELF22  SPDEF2  ELK32  
    3 SIMAP similar genes for ELF4 using alignment to 2 protein entries:     ELF4_HUMAN (see all proteins):
    ELF5    ELF1    ELF2

    ELF4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELF4 (see all 711)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411090731,2
    --129154330(+) AAAGGC/TTGGGA 2 -- ds50010--------
    rs1808023441,2
    --129154432(+) TGAAGA/CACCAG 2 -- ds50010--------
    rs735698471,2
    C,F--129154447(+) GGAAAC/GGGTGA 2 -- ds50013Minor allele frequency- G:0.20WA CSA 5
    rs1379172821,2
    C--129154874(+) AGAGCA/GCGGCC 2 -- ut310--------
    rs1154784751,2
    C,F--129154875(+) GAGCGC/TGGCCA 2 -- ut310--------
    rs1908534561,2
    --129154895(+) GTTAGA/GTCAAG 2 -- ut310--------
    rs1816297591,2
    --129154996(+) CTGACA/GTTTCT 2 -- ut310--------
    rs1862560451,2
    --129155158(+) GAAGAC/GAGAGA 2 -- ut310--------
    rs1915779741,2
    --129155196(+) CTCCCA/GTCTTC 2 -- ut310--------
    rs37888481,2
    C,F,A,H--129155611(-) CGGGGA/GTGAAG 2 -- ut3119Minor allele frequency- G:0.33NS EA WA NA CSA 1984

    HapMap Linkage Disequilibrium report for ELF4 (129198849 - 129244691 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ELF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1493190CNV Deletion17803354
    nsv7090CNV Loss18451855
    esv25673CNV Loss19812545
    nsv528290CNV Gain19592680

    Human Gene Mutation Database (HGMD): ELF4
    Locus Specific Mutation Databases (LSDB): ELF4

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300775    OMIM disorders: --

    UniProtKB/Swiss-Prot: ELF4_HUMAN, Q99607
  • Note=A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML).
    Translocation t(X;21)(q25-26;q22) with ERG

  • 9 diseases for ELF4:    
    About MalaCards
    agammaglobulinemia and isolated hormone deficiency    dental caries    acute myeloid leukemia    myeloid leukemia
    ovarian cancer    leukemia    endotheliitis    multiple myeloma
    myeloma


    ELF4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ELF4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 58.1 2 14976184 (1), 15286431 (1)
    tumors 0 5 17213815 (3), 12438253 (1)
    cancer 0 2 16581786 (1)


    Export disorders for ELF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELF4 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with ELF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties. (PubMed id 8895518)1, 2, 3, 9 Miyazaki Y.... Nimer S. (Oncogene 1996)
    2. Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein. (PubMed id 14976184)1, 2, 9 Suico M.A.... Kai H. (J. Biol. Chem. 2004)
    3. ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22). (PubMed id 16303180)1, 2 Moore S.D....Dal Cin P. (Leuk. Res. 2006)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells. (PubMed id 14625302)1, 2 Hedvat C.V.... Nimer S.D. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. (PubMed id 10207087)1, 2 Mao S.... Nimer S.D. (Mol. Cell. Biol. 1999)
    8. Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF- 1. (PubMed id 9524226)1, 2 Aryee D.N.T.... Kovar H. (Gene 1998)
    9. The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. (PubMed id 16581786)1, 9 Liu Y....Nimer S.D. (Mol. Cell. Biol. 2006)
    10. MEF up-regulates human beta-defensin 2 expression in epithelial cells. (PubMed id 15013761)1, 9 Lu Z....Kai H. (FEBS Lett. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2000 HGNC: 3319 AceView: ELF4 Ensembl:ENSG00000102034 euGenes: HUgn2000
    ECgene: ELF4 H-InvDB: ELF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELF4 gene:
    Search GeneIP for patents involving ELF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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