Aliases for ELF3 Gene
External Ids for ELF3 Gene
Previous HGNC Symbols for ELF3 Gene
Previous GeneCards Identifiers for ELF3 Gene
GeneCards Summary for ELF3 Gene
ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific )) is a Protein Coding gene. Diseases associated with ELF3 include n syndrome and sarcoma, synovial. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is ELF4.
UniProtKB/Swiss-Prot for ELF3 Gene
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).