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Aliases for ELF3 Gene

Aliases for ELF3 Gene

  • E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific ) 2 3
  • ESX 3 4 6
  • Epithelium-Specific Ets Transcription Factor 1 3 4
  • Epithelial-Restricted With Serine Box 3 4
  • Epithelium-Restricted Ets Protein ESX 3 4
  • ESE-1 3 4
  • ERT 3 4
  • E74-Like Factor 3 (ETS Domain Transcription Factor, Serine Box, Epithelial-Specific) 3
  • Ets Domain Transcription Factor, Serine Box (Epithelial-Specific) 3
  • E74-Like Factor 3 (Ets Domain Transcription Factor) 3
  • ETS-Related Transcription Factor Elf-3 3
  • E74-Like Factor 3 4
  • EPR-1 3
  • JEN 4

External Ids for ELF3 Gene

Previous HGNC Symbols for ELF3 Gene

  • ESX

Previous GeneCards Identifiers for ELF3 Gene

  • GC01P199635
  • GC01P197413
  • GC01P198446
  • GC01P199265
  • GC01P198708
  • GC01P200243
  • GC01P201977
  • GC01P173145

Summaries for ELF3 Gene

GeneCards Summary for ELF3 Gene

ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific )) is a Protein Coding gene. Diseases associated with ELF3 include retroperitoneal sarcoma. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELF3 Gene

  • Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF3 Gene

Genomics for ELF3 Gene

Regulatory Elements for ELF3 Gene

Genomic Location for ELF3 Gene

Start:
202,007,945 bp from pter
End:
202,017,188 bp from pter
Size:
9,244 bases
Orientation:
Plus strand

Genomic View for ELF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF3 Gene

Proteins for ELF3 Gene

  • Protein details for ELF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78545-ELF3_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-3
    Protein Accession:
    P78545
    Secondary Accessions:
    • B2R5Q6
    • Q6IAP8
    • Q7RU03
    • Q7Z3X2
    • Q8NFG2
    • Q99718

    Protein attributes for ELF3 Gene

    Size:
    371 amino acids
    Molecular mass:
    41454 Da
    Quaternary structure:
    • Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.

    Three dimensional structures from OCA and Proteopedia for ELF3 Gene

    Alternative splice isoforms for ELF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELF3 Gene

Proteomics data for ELF3 Gene at MOPED

Post-translational modifications for ELF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELF3 Gene

No data available for DME Specific Peptides for ELF3 Gene

Domains for ELF3 Gene

Suggested Antigen Peptide Sequences for ELF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78545

UniProtKB/Swiss-Prot:

ELF3_HUMAN :
  • P78545
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Contains 1 ETS DNA-binding domain.
  • Contains 1 PNT (pointed) domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELF3: view

No data available for Gene Families for ELF3 Gene

Function for ELF3 Gene

Molecular function for ELF3 Gene

GENATLAS Biochemistry: E74-like factor 3,transcription regulator family,expressed in the majority of epithelial cell types,targetting SPR2A during keratinocyte differentiation,putative regulation of epithelial cell differentiation,overexpressed in breast tumorigenesis
UniProtKB/Swiss-Prot Function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
UniProtKB/Swiss-Prot Induction: Transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells. Up-regulated by phorbol 12-myristate 13-acetate (PMA) in bronchial epithelial cells. By retinoic acid in MCF-7 mammary epithelial cells (at protein level).

Gene Ontology (GO) - Molecular Function for ELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 9234700
genes like me logo Genes that share ontologies with ELF3: view
genes like me logo Genes that share phenotypes with ELF3: view

miRNA for ELF3 Gene

miRTarBase miRNAs that target ELF3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ELF3 Gene

Localization for ELF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF3 Gene

Cytoplasm. Nucleus. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. {ECO:0000269 PubMed:10391676, ECO:0000269 PubMed:15169914, ECO:0000269 PubMed:17060315}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELF3 Gene COMPARTMENTS Subcellular localization image for ELF3 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for ELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9234700
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ELF3: view

Pathways for ELF3 Gene

SuperPathways for ELF3 Gene

Superpath Contained pathways
1 EGFR1 Signaling Pathway
genes like me logo Genes that share pathways with ELF3: view

Pathways by source for ELF3 Gene

1 BioSystems pathway for ELF3 Gene

Gene Ontology (GO) - Biological Process for ELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9234700
GO:0006954 inflammatory response IEP 14715662
genes like me logo Genes that share ontologies with ELF3: view

Compounds for ELF3 Gene

(6) Novoseek inferred chemical compound relationships for ELF3 Gene

Compound -log(P) Hits PubMed IDs
thymidylate 28.3 2
retinoic acid 15.6 2
5fluorouracil 3.28 1
oligonucleotide 0 2
thymidine 0 2
genes like me logo Genes that share compounds with ELF3: view

Transcripts for ELF3 Gene

Unigene Clusters for ELF3 Gene

E74-like factor 3 (ets domain transcription factor, epithelial-specific ):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELF3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a ·
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - -
SP14: -
SP15:
SP16:

ExUns: 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14:
SP15:
SP16: -

Relevant External Links for ELF3 Gene

GeneLoc Exon Structure for
ELF3
ECgene alternative splicing isoforms for
ELF3

Expression for ELF3 Gene

mRNA expression in normal human tissues for ELF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELF3 Gene

This gene is overexpressed in Bladder (6.6), Esophagus - Mucosa (6.2), Colon - Transverse (6.1), and Minor Salivary Gland (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELF3 Gene

SOURCE GeneReport for Unigene cluster for ELF3 Gene Hs.603657

mRNA Expression by UniProt/SwissProt for ELF3 Gene

P78545-ELF3_HUMAN
Tissue specificity: Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
genes like me logo Genes that share expressions with ELF3: view

Orthologs for ELF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELF3 35
  • 99.55 (n)
  • 99.73 (a)
ELF3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELF3 35
  • 83.47 (n)
  • 81.67 (a)
ELF3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELF3 35
  • 87.08 (n)
  • 86.99 (a)
ELF3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elf3 35
  • 85.14 (n)
  • 87.84 (a)
Elf3 16
Elf3 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELF3 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELF3 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elf3 35
  • 85.14 (n)
  • 88.38 (a)
chicken
(Gallus gallus)
Aves ELF3 35
  • 72.87 (n)
  • 69.44 (a)
ELF3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELF3 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elf3 35
  • 56.76 (n)
  • 56.76 (a)
zebrafish
(Danio rerio)
Actinopterygii elf3 35
  • 52.91 (n)
  • 47.56 (a)
elf3 36
  • 38 (a)
OneToOne
wufb06f04 35
fruit fly
(Drosophila melanogaster)
Insecta aop 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-97 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for ELF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELF3 Gene

ENSEMBL:
Gene Tree for ELF3 (if available)
TreeFam:
Gene Tree for ELF3 (if available)

Paralogs for ELF3 Gene

Paralogs for ELF3 Gene

Selected SIMAP similar genes for ELF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ELF3: view

Variants for ELF3 Gene

Sequence variations from dbSNP and Humsavar for ELF3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13690 -- 202,015,482(+) GTCCT(G/T)GGACT utr-variant-3-prime
rs1130193 -- 202,016,603(+) AAAGT(A/G)TAGTC utr-variant-3-prime
rs1135542 - 202,013,972(+) GGGGC(A/C)AAAAG missense, reference
rs1135660 -- 202,015,846(+) TTTTT(C/T)TAAAA utr-variant-3-prime
rs1135680 -- 202,015,951(+) CCTTT(C/T)TCCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ELF3 Gene

Variant ID Type Subtype PubMed ID
nsv873102 CNV Gain 21882294
nsv516812 CNV Loss 19592680

Relevant External Links for ELF3 Gene

HapMap Linkage Disequilibrium report
ELF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELF3 Gene

Disorders for ELF3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ELF3 Gene including...

Search for ELF3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ELF3 Gene

(8) Novoseek inferred disease relationships for ELF3 Gene

Disease -log(P) Hits PubMed IDs
sarcoma synovial 51.4 4
breast cancer 31.1 17
tumors 26.3 6
cancer 25.6 4
adenocarcinoma 22.4 1

Relevant External Links for ELF3

Genetic Association Database (GAD)
ELF3
genes like me logo Genes that share disorders with ELF3: view

No data available for UniProtKB/Swiss-Prot for ELF3 Gene

Publications for ELF3 Gene

  1. A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. (PMID: 9395241) Tymms M.J. … Kola I. (Oncogene 1997) 2 3 4 23
  2. A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor. (PMID: 9417054) Choi S.-G. … Kim S.-J. (J. Biol. Chem. 1998) 3 4 23
  3. Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP). (PMID: 10391676) Chang C.-H. … Benz C.C. (Oncogene 1999) 3 4 23
  4. Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. (PMID: 10773884) Brembeck F.H. … Rustgi A.K. (Oncogene 2000) 3 4 23
  5. ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. (PMID: 12414801) Kwon J.H. … Keates A.C. (J. Biol. Chem. 2003) 3 4 23

Products for ELF3 Gene

  • Addgene plasmids for ELF3

Sources for ELF3 Gene

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