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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ELF3 Gene

protein-coding   GIFtS: 61
GCID: GC01P201977

E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific...


(Previous symbol: ESX)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific
)1 2
     EPR-12
ESX1 2 3 5     E74-Like Factor 3 (Ets Domain Transcription Factor)2
Epithelial-Restricted With Serine Box2 3     E74-Like Factor 3 (ETS Domain Transcription Factor, Serine Box,
Epithelial-Specific)2
Epithelium-Restricted Ets Protein ESX2 3     Ets Domain Transcription Factor, Serine Box (Epithelial-Specific)2
Epithelium-Specific Ets Transcription Factor 12 3     ETS-Related Transcription Factor Elf-32
ERT2 3     JEN3
ESE-12 3     E74-Like Factor 33

External Ids:    HGNC: 33181   Entrez Gene: 19992   Ensembl: ENSG000001634357   OMIM: 6021915   UniProtKB: P785453   

Export aliases for ELF3 gene to outside databases

Previous GC identifers: GC01P199635 GC01P197413 GC01P198446 GC01P199265 GC01P198708 GC01P200243 GC01P173145


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ELF3 Gene: 
ELF3 (E74-like factor 3 (ets domain transcription factor, epithelial-specific )) is a protein-coding gene. Diseases associated with ELF3 include retroperitoneal sarcoma, and pandas. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot: ELF3_HUMAN, P78545
Function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus
nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with
RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2,
PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular
inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical
downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and
involution. Plays an important role in the regulation of transcription with TATA-less promoters in
preimplantation embryos, which is essential in preimplantation development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ELF3 gene promoter:
         c-Fos   E2F-1   Sp1   AP-1   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ELF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ELF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.2   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.2

ELF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELF3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P201977:  view genomic region     (about GC identifiers)

Start:
201,977,073 bp from pter      End:
201,986,316 bp from pter
Size:
9,244 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ELF3_HUMAN, P78545 (See protein sequence)
Recommended Name: ETS-related transcription factor Elf-3  
Size: 371 amino acids; 41454 Da
Subunit: Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3
and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3
to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3
Subcellular location: Cytoplasm. Nucleus. Note=Localizes to the cytoplasm where it has been shown to transform
MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to
the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a
transcription-dependent mechanism
1 PDB 3D structure from and Proteopedia for ELF3:
2E8P (3D)    
Secondary accessions: B2R5Q6 Q6IAP8 Q7RU03 Q7Z3X2 Q8NFG2 Q99718
Alternative splicing: 2 isoforms:  P78545-1   P78545-2   

Explore the universe of human proteins at neXtProt for ELF3: NX_P78545

Explore proteomics data for ELF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78545

  • ELF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ELF3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001107781.1  NP_004424.3  

    ENSEMBL proteins: 
     ENSP00000352673   ENSP00000356253   ENSP00000356252   ENSP00000405162  

    Human Recombinant Protein Products for ELF3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ELF3
    OriGene Protein Over-expression Lysate for ELF3
    OriGene MassSpec for ELF3 
    OriGene Custom Protein Services for ELF3
    GenScript Custom Purified and Recombinant Proteins Services for ELF3
    Novus Biologicals ELF3 Proteins
    Novus Biologicals ELF3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ELF3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9234700
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    ELF3 for ontologies           About GeneDecksing



    ELF3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ELF3
    OriGene Antibodies for ELF3
    OriGene Custom Antibody Services for ELF3
    GenScript Custom Superior Antibodies Services for ELF3
    Novus Biologicals ELF3 Antibodies
    Abcam antibodies for ELF3
    Cloud-Clone Corp. Antibodies for ELF3 
    ThermoFisher Antibody for ELF3
    LSBio Antibodies in human, mouse, rat for ELF3 

    Assay Products for ELF3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ELF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ELF3 
    Cloud-Clone Corp. CLIAs for ELF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR017956 AT_hook_DNA-bd_motif
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry P78545

    ProtoNet protein and cluster: P78545

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ELF3_HUMAN, P78545
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    ELF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELF3_HUMAN, P78545
    Function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus
    nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with
    RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2,
    PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular
    inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical
    downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and
    involution. Plays an important role in the regulation of transcription with TATA-less promoters in
    preimplantation embryos, which is essential in preimplantation development (By similarity)
    Induction: Transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells. Up-regulated
    by phorbol 12-myristate 13-acetate (PMA) in bronchial epithelial cells. By retinoic acid in MCF-7 mammary
    epithelial cells (at protein level)

         Genatlas biochemistry entry for ELF3:
    E74-like factor 3,transcription regulator family,expressed in the majority of epithelial cell types,targetting
    SPR2A during keratinocyte differentiation,putative regulation of epithelial cell differentiation,overexpressed in
    breast tumorigenesis

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS9234700
    GO:0003713transcription coactivator activity IDA12624109
    GO:0005515protein binding IPI10391676
    GO:0043565sequence-specific DNA binding IEA--
         
    ELF3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ELF3:
     Elongated cells  Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Elf3):
     behavior/neurological  digestive/alimentary  growth/size  mortality/aging 

    ELF3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ELF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ELF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELF3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELF3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELF3
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ELF3 (see all 17):
    hsa-miR-1321 hsa-miR-513a-5p hsa-miR-1205 hsa-miR-3162-5p hsa-miR-124 hsa-miR-133a hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidELF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ELF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELF3

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of ELF3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ELF3 (see all 14)
    OriGene ORF clones in mouse, rat for ELF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELF3 (NM_001114309)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF3
    Sirion Biotech Customized lentivirus for stable overexpression of ELF3 
                         Customized lentivirus expression plasmids for stable overexpression of ELF3 

    Cell Line
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    Search LifeMap BioReagents cell lines for ELF3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ELF3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway
    2Selected targets of ESR1
    Selected targets of ESR1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ELF3
        Selected targets of ESR1


    1 BioSystems Pathway for ELF3
        EGFR1 Signaling Pathway



    ELF3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ELF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for ELF3 (P785453 ENSP000003526734) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BFP628073, ENSP000003530744I2D: score=1 STRING: ENSP00000353074
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS9234700
    GO:0006954inflammatory response IEP14715662
    GO:0007275multicellular organismal development TAS9234700

    ELF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ELF3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ELF3

    6 Novoseek inferred chemical compound relationships for ELF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidylate 28.3 2 16892554 (1), 16243820 (1)
    retinoic acid 15.6 3 12894236 (1), 15059897 (1)
    5fluorouracil 3.28 1 16243820 (1)
    oligonucleotide 0 2 15075319 (1), 14582709 (1)
    thymidine 0 2 16892554 (1), 16243820 (1)
    serine 0 2 15169914 (1), 17491012 (1)

    Search CenterWatch for drugs/clinical trials and news about ELF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ELF3 gene (2 alternative transcripts): 
    NM_001114309.1  NM_004433.4  

    Unigene Cluster for ELF3:

    E74-like factor 3 (ets domain transcription factor, epithelial-specific )
    Hs.603657  [show with all ESTs]
    Unigene Representative Sequence: NM_001114309
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359651(uc001gxg.4) ENST00000367284(uc001gxi.4 uc001gxh.4)
    ENST00000367283 ENST00000495848 ENST00000490203 ENST00000498017 ENST00000446188
    ENST00000470384 ENST00000479874 ENST00000475698
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELF3
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ELF3 (see all 17):
    hsa-miR-1321 hsa-miR-513a-5p hsa-miR-1205 hsa-miR-3162-5p hsa-miR-124 hsa-miR-133a hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidELF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ELF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELF3
    Clone
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    OriGene clones in human, mouse for ELF3 (see all 14)
    OriGene ORF clones in mouse, rat for ELF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELF3 (NM_001114309)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF3
    Sirion Biotech Customized lentivirus for stable overexpression of ELF3 
                         Customized lentivirus expression plasmids for stable overexpression of ELF3 
    Primer
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    OriGene qPCR primer pairs and template standards for ELF3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELF3

    Additional mRNA sequence: 

    AF016295.1 AF017307.1 AF517841.1 AK225446.1 AK309265.1 AK310814.1 AK312273.1 BC003569.1 
    BC107034.2 CR457106.1 U66894.1 U73843.1 U73844.1 U97156.1 

    24/28 DOTS entries (see all 28):

    DT.447793  DT.100692616  DT.121353816  DT.121353824  DT.92024916  DT.100793150  DT.95244987  DT.100710385 
    DT.121353791  DT.95073728  DT.95266424  DT.100793155  DT.95166054  DT.121353998  DT.121354014  DT.121353977 
    DT.97854644  DT.87016355  DT.100793151  DT.100793162  DT.75116628  DT.91763788  DT.95166057  DT.95166059 

    24/429 AceView cDNA sequences (see all 429):

    BM825276 BM789309 BM784312 AI274658 AW294177 AA620466 AI079149 AW513831 
    BM753970 AI269799 BM746921 AI350214 AA516424 BI256831 AW272190 BE794085 
    BX092353 AI768934 AW613018 BM833500 BQ023145 AL698009 AI796580 AA299413 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ELF3 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a ·
    SP1:                                            -           -     -           -                       -     -                 -                       -         
    SP2:                                                        -     -           -                       -     -                 -                       -         
    SP3:                                            -           -     -           -                       -     -           -     -                       -         
    SP4:                                                        -     -           -                       -     -                 -                       -         
    SP5:                                            -           -     -           -                       -     -                 -                                 

    ExUns: 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:              -           -                     
    SP2:              -           -                     
    SP3:              -           -                     
    SP4:              -           -                     
    SP5:                                                


    ECgene alternative splicing isoforms for ELF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ELF3 expression in normal human tissues (normalized intensities)      ELF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGCACTG
    ELF3 Expression
    About this image


    ELF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
             rectum   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             urinary bladder ; urothelial cells   
             visceral organ/urethra of male/pelvic urethra of male   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             Human Renal Epithelial Cells (HREpiC)   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in tubules   

    See ELF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ELF3

    SOURCE GeneReport for Unigene cluster: Hs.603657

    UniProtKB/Swiss-Prot: ELF3_HUMAN, P78545
    Tissue specificity: Expressed exclusively in tissues containing a high content of terminally differentiated
    epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ELF3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elf31 , 5 E74-like factor 31, 5 85.14(n)1
    87.84(a)1
      1 (58.42 cM)5
    137101  NM_001163131.11  NP_001156603.11 
     1352535745 
    chicken
    (Gallus gallus)
    Aves ELF31 E74-like factor 3 (ets domain transcription factor, more 72.47(n)
    67.96(a)
      421177  XM_419257.3  XP_419257.3 
    lizard
    (Anolis carolinensis)
    Reptilia ELF36
    E74-like factor 3 (ets domain transcription factor...
    59(a)
    1 ↔ 1
    4(132396259-132420457)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb06f042 Transcribed sequence with weak similarity to protein more 81.41(n)    CA475132.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lin-16
    elk-26
    (see all 3)
    Protein ELK-2
    (see all 3)
    9(a)
    3(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    IV(2275877-2300351)
    X(106971-109378)


    ENSEMBL Gene Tree for ELF3 (if available)
    TreeFam Gene Tree for ELF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ELF3 gene
    ELF42  ELF12  ELF52  ETV72  EHF2  ELF22  SPDEF2  ETV62  
    2 SIMAP similar genes for ELF3 using alignment to 2 protein entries:     ELF3_HUMAN (see all proteins):
    ELF5    EHF

    ELF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/280 SNPs in ELF3 are shown (see all 280)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94277151,2
    C,F,A,H--201977827(+) GGAGGT/GGGGTC 2 -- us2k127Minor allele frequency- G:0.40NS EA NA WA CSA 2772
    rs569439021,2
    C--201977861(+) TTTTG-/TTTTTT 2 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs354015721,2
    --201977866(+) TTTTTG/TTTTTT 2 -- us2k11Minor allele frequency- T:0.00NA 2
    rs2021164641,2
    C--201977867(+) TTTTTG/TTTTTT 2 -- us2k10--------
    rs1125908971,2
    F--201977889(+) GATTAC/TAGGTG 2 -- us2k12Minor allele frequency- T:0.07CSA WA 120
    rs730744531,2
    C--201977903(+) GCCACC/TGGATC 2 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1127252441,2
    F--201977922(+) CAAATG/ACATAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs108008071,2
    C,F,A,H--201978049(+) AACCCC/TGTCTC 2 -- us2k1 ese33Minor allele frequency- T:0.50NA 6
    rs787393831,2
    C--201978060(+) TACTAA/CAAATA 2 -- us2k10--------
    rs39287241,2
    C,F,A,H--201978068(+) ATACAA/GAAAGC 2 -- us2k18Minor allele frequency- G:0.31NA WA 134

    HapMap Linkage Disequilibrium report for ELF3 (201977073 - 201986316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ELF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516812CNV Loss19592680
    nsv873102CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602191    OMIM disorders: --

    16 diseases for ELF3:    About MalaCards
    retroperitoneal sarcoma    pandas    synovial sarcoma    oligodendroglioma
    conjunctivitis    lung adenocarcinoma    sarcoma    oral squamous cell carcinoma
    adenocarcinoma    renal cell carcinoma    squamous cell carcinoma    breast cancer
    gastric cancer    colorectal cancer    retinitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ELF3:
    Retroperitoneal sarcoma

    ELF3 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for ELF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma synovial 51.4 4 12414507 (2), 17060315 (2)
    breast cancer 31.1 20 14997048 (5), 12713734 (3), 15169914 (2), 12477051 (2) (see all 9)
    tumors 26.3 7 16319692 (2), 12894236 (1), 19961621 (1), 12031094 (1) (see all 5)
    cancer 25.6 4 16307850 (1), 9395241 (1), 10773884 (1), 14582709 (1)
    adenocarcinoma 22.4 1 9395241 (1)
    inflammation 1.81 7 18475289 (1), 12746898 (1), 14715662 (1), 15794755 (1) (see all 5)
    necrosis 0 2 12894236 (1), 12746898 (1)
    rheumatoid arthritis 0 2 12746898 (1), 14715662 (1)

    Genetic Association Database (GAD): ELF3

    Export disorders for ELF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ELF3 gene, integrated from 9 sources (see all 102):
    (articles sorted by number of sources associating them with ELF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. (PubMed id 9395241)1, 2, 3, 9 Tymms M.J.... Kola I. (1997)
    2. ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis. (PubMed id 9129154)1, 2, 3 Chang C.-H.... Benz C.C. (1997)
    3. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. (PubMed id 14767472)1, 2, 9 Schedin P.J.... Gutierrez-Hartmann A. (2004)
    4. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. (PubMed id 14715662)1, 2, 9 Brown C.... Oettgen P. (2004)
    5. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. (PubMed id 9234700)1, 2, 9 Oettgen P.... Libermann T.A. (1997)
    6. Partially unspliced and fully spliced ELF3 mRNA, including a new Alu element in human breast cancer. (PubMed id 14997048)1, 2, 9 Kaplan M.H.... Dosik M.H. (2004)
    7. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PubMed id 15075319)1, 2, 9 Wang H.... Oettgen P. (2004)
    8. Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP). (PubMed id 10391676)1, 2, 9 Chang C.-H.... Benz C.C. (1999)
    9. Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. (PubMed id 10773884)1, 2, 9 Brembeck F.H.... Rustgi A.K. (2000)
    10. Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3. (PubMed id 17060315)1, 2, 9 Kohno Y.... Toguchida J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1999 HGNC: 3318 AceView: ELF3 Ensembl:ENSG00000163435 euGenes: HUgn1999
    ECgene: ELF3 H-InvDB: ELF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ELF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ELF3 gene:
    Search GeneIP for patents involving ELF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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