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ELF3 Gene

protein-coding   GIFtS: 61
GCID: GC01P201977

E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific...


(Previous symbol: ESX)
  See ELF3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific
)1 2
     EPR-12
ESX1 2 3 5     E74-Like Factor 3 (Ets Domain Transcription Factor)2
Epithelial-Restricted With Serine Box2 3     E74-Like Factor 3 (ETS Domain Transcription Factor, Serine Box,
Epithelial-Specific)2
Epithelium-Restricted Ets Protein ESX2 3     Ets Domain Transcription Factor, Serine Box (Epithelial-Specific)2
Epithelium-Specific Ets Transcription Factor 12 3     ETS-Related Transcription Factor Elf-32
ERT2 3     JEN3
ESE-12 3     E74-Like Factor 33

External Ids:    HGNC: 33181   Entrez Gene: 19992   Ensembl: ENSG000001634357   OMIM: 6021915   UniProtKB: P785453   

Export aliases for ELF3 gene to outside databases

Previous GC identifers: GC01P199635 GC01P197413 GC01P198446 GC01P199265 GC01P198708 GC01P200243 GC01P173145


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ELF3 Gene:
ELF3 (E74-like factor 3 (ets domain transcription factor, epithelial-specific )) is a protein-coding gene. Diseases associated with ELF3 include retroperitoneal sarcoma. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ELF3_HUMAN, P78545
Function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus
nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with
RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2,
PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular
inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical
downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and
involution. Plays an important role in the regulation of transcription with TATA-less promoters in
preimplantation embryos, which is essential in preimplantation development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELF3 gene promoter:
         c-Fos   E2F-1   Sp1   AP-1   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ELF3 promoter sequence
   Search Chromatin IP Primers for ELF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.2   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.2

ELF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELF3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P201977:  view genomic region     (about GC identifiers)

Start:
201,977,073 bp from pter      End:
201,986,316 bp from pter
Size:
9,244 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ELF3_HUMAN, P78545 (See protein sequence)
Recommended Name: ETS-related transcription factor Elf-3  
Size: 371 amino acids; 41454 Da
Subunit: Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3
and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3
to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3
1 PDB 3D structure from and Proteopedia for ELF3:
2E8P (3D)    
Secondary accessions: B2R5Q6 Q6IAP8 Q7RU03 Q7Z3X2 Q8NFG2 Q99718
Alternative splicing: 2 isoforms:  P78545-1   P78545-2   

Explore the universe of human proteins at neXtProt for ELF3: NX_P78545

Explore proteomics data for ELF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ELF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107781.1  NP_004424.3  

    ENSEMBL proteins: 
     ENSP00000352673   ENSP00000356253   ENSP00000356252   ENSP00000405162  

    ELF3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for ELF3
    OriGene Custom Protein Services for ELF3
    GenScript Custom Purified and Recombinant Proteins Services for ELF3
    Novus Biologicals ELF3 Proteins
    Novus Biologicals ELF3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ELF3

     
    Search eBioscience for Proteins for ELF3 

    ELF3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ELF3 Antibodies
    Abcam antibodies for ELF3
    Cloud-Clone Corp. Antibodies for ELF3
    ThermoFisher Antibody for ELF3
    LSBio Antibodies in human, mouse, rat for ELF3

    ELF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ELF3
    Cloud-Clone Corp. CLIAs for ELF3
    Search eBioscience for ELISAs for ELF3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR017956 AT_hook_DNA-bd_motif
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry P78545

    ProtoNet protein and cluster: P78545

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ELF3_HUMAN, P78545
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    Find genes that share domains with ELF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELF3_HUMAN, P78545
    Function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus
    nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with
    RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2,
    PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular
    inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical
    downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and
    involution. Plays an important role in the regulation of transcription with TATA-less promoters in
    preimplantation embryos, which is essential in preimplantation development (By similarity)
    Induction: Transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells. Up-regulated
    by phorbol 12-myristate 13-acetate (PMA) in bronchial epithelial cells. By retinoic acid in MCF-7 mammary
    epithelial cells (at protein level)

         Genatlas biochemistry entry for ELF3:
    E74-like factor 3,transcription regulator family,expressed in the majority of epithelial cell types,targetting
    SPR2A during keratinocyte differentiation,putative regulation of epithelial cell differentiation,overexpressed in
    breast tumorigenesis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS9234700
    GO:0003713transcription coactivator activity IDA12624109
    GO:0005515protein binding IPI10391676
         
    Find genes that share ontologies with ELF3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ELF3:
     Elongated cells  Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Elf3):
     behavior/neurological  digestive/alimentary  growth/size/body  mortality/aging 

    Find genes that share phenotypes with ELF3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELF3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ELF3:
    hsa-mir-124-3p (MIRT023041), hsa-mir-9-5p (MIRT021421)

    Block miRNA regulation of human, mouse, rat ELF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELF3 (see all 17):
    hsa-miR-1321 hsa-miR-513a-5p hsa-miR-1205 hsa-miR-3162-5p hsa-miR-124 hsa-miR-133a hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidELF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ELF3
    Predesigned siRNA for gene silencing in human, mouse, rat ELF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ELF3

    Clone
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    OriGene clones in human, mouse for ELF3 (see all 12)
    OriGene ORF clones in mouse, rat for ELF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELF3 (NM_001114309)
    Sino Biological Human cDNA Clone for ELF3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF3
    Addgene plasmids for ELF3 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ELF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELF3_HUMAN, P78545: Cytoplasm. Nucleus. Note=Localizes to the cytoplasm where it has been shown to transform
    MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to
    the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a
    transcription-dependent mechanism
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus4
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9234700
    GO:0005737cytoplasm IEA--
    GO:0005794Golgi apparatus ----

    Find genes that share ontologies with ELF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELF3 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of ESR1
    Selected targets of ESR1
    2EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway


    1 BioSystems Pathway for ELF3
        EGFR1 Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELF3
    Interactions:

        GeneGlobe Interaction Network for ELF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ELF3 (P785453 ENSP000003526734) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BFP628073, ENSP000003530744I2D: score=1 STRING: ENSP00000353074
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter TAS9234700
    GO:0006954inflammatory response IEP14715662

    Find genes that share ontologies with ELF3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELF3

    6 Novoseek inferred chemical compound relationships for ELF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidylate 28.3 2 16892554 (1), 16243820 (1)
    retinoic acid 15.6 3 12894236 (1), 15059897 (1)
    5fluorouracil 3.28 1 16243820 (1)
    oligonucleotide 0 2 15075319 (1), 14582709 (1)
    thymidine 0 2 16892554 (1), 16243820 (1)
    serine 0 2 15169914 (1), 17491012 (1)



    Find genes that share compounds with ELF3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ELF3 gene (2 alternative transcripts): 
    NM_001114309.1  NM_004433.4  

    Unigene Cluster for ELF3:

    E74-like factor 3 (ets domain transcription factor, epithelial-specific )
    Hs.603657  [show with all ESTs]
    Unigene Representative Sequence: NM_001114309
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359651(uc001gxg.4) ENST00000367284(uc001gxi.4 uc001gxh.4)
    ENST00000367283 ENST00000495848 ENST00000490203 ENST00000498017 ENST00000446188
    ENST00000470384 ENST00000479874 ENST00000475698
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ELF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELF3 (see all 17):
    hsa-miR-1321 hsa-miR-513a-5p hsa-miR-1205 hsa-miR-3162-5p hsa-miR-124 hsa-miR-133a hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidELF3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ELF3
    Predesigned siRNA for gene silencing in human, mouse, rat ELF3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ELF3 (NM_001114309)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF3
    Addgene plasmids for ELF3 
    Primer
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    OriGene qPCR primer pairs and template standards for ELF3
    OriGene qSTAR qPCR primer pairs in human, mouse for ELF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELF3
      QuantiTect SYBR Green Assays in human, mouse, rat ELF3
      QuantiFast Probe-based Assays in human, mouse, rat ELF3

    Additional mRNA sequence: 

    AF016295.1 AF017307.1 AF517841.1 AK225446.1 AK309265.1 AK310814.1 AK312273.1 BC003569.1 
    BC107034.2 CR457106.1 U66894.1 U73843.1 U73844.1 U97156.1 

    Selected DOTS entries (see all 28):

    DT.447793  DT.100692616  DT.121353816  DT.121353824  DT.92024916  DT.100793150  DT.95244987  DT.100710385 
    DT.121353791  DT.95073728  DT.95266424  DT.100793155  DT.95166054  DT.121353998  DT.121354014  DT.121353977 
    DT.97854644  DT.87016355  DT.100793151  DT.100793162  DT.75116628  DT.91763788  DT.95166057  DT.95166059 

    Selected AceView cDNA sequences (see all 429):

    BI765097 BP334311 BE669909 AW630746 AW611847 AA299413 AI269799 AW294177 
    AA159295 AI634698 AI269797 BF590754 U73843 AI823854 AI984236 AA989350 
    CR597744 BM742829 BM664787 BM825276 AL698009 AI768934 BC003569 AW272190 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ELF3 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a ·
    SP1:                                            -           -     -           -                       -     -                 -                       -         
    SP2:                                                        -     -           -                       -     -                 -                       -         
    SP3:                                            -           -     -           -                       -     -           -     -                       -         
    SP4:                                                        -     -           -                       -     -                 -                       -         
    SP5:                                            -           -     -           -                       -     -                 -                                 

    ExUns: 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:              -           -                     
    SP2:              -           -                     
    SP3:              -           -                     
    SP4:              -           -                     
    SP5:                                                


    ECgene alternative splicing isoforms for ELF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGCACTG
    ELF3 Expression
    About this image


    ELF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Ovary (Reproductive System)
             Oviduct
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
    ELF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.603657

    UniProtKB/Swiss-Prot: ELF3_HUMAN, P78545
    Tissue specificity: Expressed exclusively in tissues containing a high content of terminally differentiated
    epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELF3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elf31 , 5 E74-like factor 31, 5 85.14(n)1
    87.84(a)1
      1 (58.42 cM)5
    137101  NM_001163131.11  NP_001156603.11 
     1352535745 
    chicken
    (Gallus gallus)
    Aves ELF31 E74-like factor 3 (ets domain transcription factor, more 72.87(n)
    69.44(a)
      421177  XM_419257.4  XP_419257.3 
    lizard
    (Anolis carolinensis)
    Reptilia ELF36
    E74-like factor 3 (ets domain transcription factor...
    59(a)
    1 ↔ 1
    4(132396259-132420457)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia elf31 E74-like factor 3 (ets domain transcription factor, more 56.76(n)
    56.76(a)
      100144720  XM_002932989.2  XP_002933035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb06f042 Transcribed sequence with weak similarity to protein more 81.41(n)    CA475132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aop6
    anterior open
    12(a)
    1 → many
    2L(2156484-2178749)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-976
    Protein TAG-97, isoform a
    19(a)
    1 → many
    X(15369998-15377685) WBGene00006462


    ENSEMBL Gene Tree for ELF3 (if available)
    TreeFam Gene Tree for ELF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELF3 gene
    ELK42  ELF42  ELF12  ELF52  ETV72  ELK12  ETV62  EHF2  
    ELF22  SPDEF2  ELK32  
    2 SIMAP similar genes for ELF3 using alignment to 2 protein entries:     ELF3_HUMAN (see all proteins):
    ELF5    EHF

    Find genes that share paralogs with ELF3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELF3 (see all 280)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94277151,2
    C,F,A,H--201977827(+) GGAGGT/GGGGTC 2 -- us2k127Minor allele frequency- G:0.40NS EA NA WA CSA 2772
    rs569439021,2
    C--201977861(+) TTTTG-/TTTTTT 2 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs354015721,2
    --201977866(+) TTTTTG/TTTTTT 2 -- us2k11Minor allele frequency- T:0.00NA 2
    rs2021164641,2
    C--201977867(+) TTTTTG/TTTTTT 2 -- us2k10--------
    rs1125908971,2
    F--201977889(+) GATTAC/TAGGTG 2 -- us2k12Minor allele frequency- T:0.07CSA WA 120
    rs730744531,2
    C--201977903(+) GCCACC/TGGATC 2 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1127252441,2
    F--201977922(+) CAAATG/ACATAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs108008071,2
    C,F,A,H--201978049(+) AACCCC/TGTCTC 2 -- us2k1 ese33Minor allele frequency- T:0.50NA 6
    rs787393831,2
    C--201978060(+) TACTAA/CAAATA 2 -- us2k10--------
    rs39287241,2
    C,F,A,H--201978068(+) ATACAA/GAAAGC 2 -- us2k18Minor allele frequency- G:0.31NA WA 134

    HapMap Linkage Disequilibrium report for ELF3 (201977073 - 201986316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ELF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516812CNV Loss19592680
    nsv873102CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602191    OMIM disorders: --

    1 disease for ELF3:    
    About MalaCards
    retroperitoneal sarcoma

    1 disease from the University of Copenhagen DISEASES database for ELF3:
    Retroperitoneal sarcoma

    Find genes that share disorders with ELF3           About GenesLikeMe

    8 Novoseek inferred disease relationships for ELF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma synovial 51.4 4 12414507 (2), 17060315 (2)
    breast cancer 31.1 20 14997048 (5), 12713734 (3), 15169914 (2), 12477051 (2) (see all 9)
    tumors 26.3 7 16319692 (2), 12894236 (1), 19961621 (1), 12031094 (1) (see all 5)
    cancer 25.6 4 16307850 (1), 9395241 (1), 10773884 (1), 14582709 (1)
    adenocarcinoma 22.4 1 9395241 (1)
    inflammation 1.81 7 18475289 (1), 12746898 (1), 14715662 (1), 15794755 (1) (see all 5)
    necrosis 0 2 12894236 (1), 12746898 (1)
    rheumatoid arthritis 0 2 12746898 (1), 14715662 (1)

    Genetic Association Database (GAD): ELF3

    Export disorders for ELF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELF3 gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with ELF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. (PubMed id 9395241)1, 2, 3, 9 Tymms M.J.... Kola I. (Oncogene 1997)
    2. ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis. (PubMed id 9129154)1, 2, 3 Chang C.-H.... Benz C.C. (Oncogene 1997)
    3. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. (PubMed id 14767472)1, 2, 9 Schedin P.J.... Gutierrez-Hartmann A. (Oncogene 2004)
    4. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. (PubMed id 14715662)1, 2, 9 Brown C.... Oettgen P. (J. Biol. Chem. 2004)
    5. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. (PubMed id 9234700)1, 2, 9 Oettgen P.... Libermann T.A. (Mol. Cell. Biol. 1997)
    6. Partially unspliced and fully spliced ELF3 mRNA, including a new Alu element in human breast cancer. (PubMed id 14997048)1, 2, 9 Kaplan M.H.... Dosik M.H. (Breast Cancer Res. Treat. 2004)
    7. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PubMed id 15075319)1, 2, 9 Wang H.... Oettgen P. (J. Biol. Chem. 2004)
    8. Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP). (PubMed id 10391676)1, 2, 9 Chang C.-H.... Benz C.C. (Oncogene 1999)
    9. Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. (PubMed id 10773884)1, 2, 9 Brembeck F.H.... Rustgi A.K. (Oncogene 2000)
    10. Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3. (PubMed id 17060315)1, 2, 9 Kohno Y.... Toguchida J. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1999 HGNC: 3318 AceView: ELF3 Ensembl:ENSG00000163435 euGenes: HUgn1999
    ECgene: ELF3 H-InvDB: ELF3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELF3 gene:
    Search GeneIP for patents involving ELF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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