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Aliases for ELF2 Gene

Aliases for ELF2 Gene

  • E74 Like ETS Transcription Factor 2 2 3
  • E74-Like Factor 2 (Ets Domain Transcription Factor) 2 3 5
  • NERF 3 4
  • Ets Family Transcription Factor ELF2C 3
  • New Ets-Related Factor 3
  • New ETS-Related Factor 4
  • E74-Like Factor 2 4
  • NERF-1a,B 3
  • NERF-1A 3
  • NERF-1B 3
  • NERF-2 3
  • EU32 3

External Ids for ELF2 Gene

Previous GeneCards Identifiers for ELF2 Gene

  • GC04M140884
  • GC04M140278
  • GC04M140445
  • GC04M140556
  • GC04M140336
  • GC04M140198
  • GC04M139978
  • GC04M135708

Summaries for ELF2 Gene

GeneCards Summary for ELF2 Gene

ELF2 (E74 Like ETS Transcription Factor 2) is a Protein Coding gene. Among its related pathways are G-protein activation and Immune response IL-23 signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELF2 Gene

  • Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.

  • Isoform 2 may function in repression of RUNX1-mediated transactivation.

Gene Wiki entry for ELF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF2 Gene

Genomics for ELF2 Gene

Regulatory Elements for ELF2 Gene

Enhancers for ELF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELF2 on UCSC Golden Path with GeneCards custom track

Promoters for ELF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ELF2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ELF2 gene promoter:

Genomic Location for ELF2 Gene

Chromosome:
4
Start:
139,028,112 bp from pter
End:
139,177,218 bp from pter
Size:
149,107 bases
Orientation:
Minus strand

Genomic View for ELF2 Gene

Genes around ELF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF2 Gene

Proteins for ELF2 Gene

  • Protein details for ELF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15723-ELF2_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-2
    Protein Accession:
    Q15723
    Secondary Accessions:
    • E9PCX3
    • Q15724
    • Q15725
    • Q6P1K5

    Protein attributes for ELF2 Gene

    Size:
    593 amino acids
    Molecular mass:
    63967 Da
    Quaternary structure:
    • Interacts with the LIM domains of LMO2 (By similarity). Interacts via its N-terminal region with RUNX1.
    SequenceCaution:
    • Sequence=AAH65025.1; Type=Frameshift; Positions=541; Evidence={ECO:0000305};

    Alternative splice isoforms for ELF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELF2 Gene

Proteomics data for ELF2 Gene at MOPED

Post-translational modifications for ELF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ELF2 Gene

Domains & Families for ELF2 Gene

Gene Families for ELF2 Gene

Protein Domains for ELF2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15723

UniProtKB/Swiss-Prot:

ELF2_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELF2: view

Function for ELF2 Gene

Molecular function for ELF2 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
UniProtKB/Swiss-Prot Function:
Isoform 2 may function in repression of RUNX1-mediated transactivation.

Gene Ontology (GO) - Molecular Function for ELF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 14970218
genes like me logo Genes that share ontologies with ELF2: view
genes like me logo Genes that share phenotypes with ELF2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELF2 Gene

Localization for ELF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELF2 Gene COMPARTMENTS Subcellular localization image for ELF2 gene
Compartment Confidence
nucleus 5
cytosol 2
vacuole 1

Gene Ontology (GO) - Cellular Components for ELF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ELF2: view

Pathways & Interactions for ELF2 Gene

genes like me logo Genes that share pathways with ELF2: view

Pathways by source for ELF2 Gene

1 BioSystems pathway for ELF2 Gene
1 PharmGKB pathway for ELF2 Gene
1 GeneGo (Thomson Reuters) pathway for ELF2 Gene

Interacting Proteins for ELF2 Gene

Gene Ontology (GO) - Biological Process for ELF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 14970218
genes like me logo Genes that share ontologies with ELF2: view

No data available for SIGNOR curated interactions for ELF2 Gene

Drugs & Compounds for ELF2 Gene

No Compound Related Data Available

Transcripts for ELF2 Gene

Unigene Clusters for ELF2 Gene

E74-like factor 2 (ets domain transcription factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1:
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for ELF2 Gene

GeneLoc Exon Structure for
ELF2
ECgene alternative splicing isoforms for
ELF2

Expression for ELF2 Gene

mRNA expression in normal human tissues for ELF2 Gene

Protein differential expression in normal tissues from HIPED for ELF2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (48.2) and Heart (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ELF2 Gene



SOURCE GeneReport for Unigene cluster for ELF2 Gene Hs.634040

mRNA Expression by UniProt/SwissProt for ELF2 Gene

Q15723-ELF2_HUMAN
Tissue specificity: Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with ELF2: view

Protein tissue co-expression partners for ELF2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ELF2 Gene

Orthologs for ELF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELF2 35
  • 94.66 (n)
  • 97.25 (a)
ELF2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELF2 35
  • 94.76 (n)
  • 97.93 (a)
ELF2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elf2 35
  • 88.54 (n)
  • 92.23 (a)
Elf2 16
Elf2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELF2 35
  • 99.83 (n)
  • 100 (a)
ELF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elf2 35
  • 89.69 (n)
  • 92.92 (a)
oppossum
(Monodelphis domestica)
Mammalia ELF2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELF2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELF2 35
  • 80.26 (n)
  • 85.2 (a)
ELF2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELF2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17593 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19357 35
zebrafish
(Danio rerio)
Actinopterygii elf2 35
elf2b 35
  • 61.61 (n)
  • 66.51 (a)
elf2a 36
  • 49 (a)
OneToMany
elf2b 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eip74EF 37
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea C24A1.2 37
  • 56 (a)
elf-1 36
  • 25 (a)
ManyToMany
ets-8 36
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for ELF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELF2 Gene

ENSEMBL:
Gene Tree for ELF2 (if available)
TreeFam:
Gene Tree for ELF2 (if available)

Paralogs for ELF2 Gene

Paralogs for ELF2 Gene

(8) SIMAP similar genes for ELF2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ELF2 Gene

genes like me logo Genes that share paralogs with ELF2: view

Variants for ELF2 Gene

Sequence variations from dbSNP and Humsavar for ELF2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs706307 -- 139,066,855(-) TTACA(G/T)ACAGg intron-variant
rs901724 -- 139,141,632(-) ACTTT(A/G)TGGGG intron-variant
rs901725 -- 139,141,631(-) CTTTG(G/T)GGGGG intron-variant
rs1055905 -- 139,149,039(-) TGGGA(C/G)AAAGT intron-variant
rs1063722 -- 139,115,073(-) AGCTC(C/T)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELF2 Gene

Variant ID Type Subtype PubMed ID
nsv880160 CNV Gain 21882294
esv275286 CNV Gain+Loss 21479260

Variation tolerance for ELF2 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ELF2 Gene

Disorders for ELF2 Gene

Relevant External Links for ELF2

Genetic Association Database (GAD)
ELF2
Human Genome Epidemiology (HuGE) Navigator
ELF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELF2

No disorders were found for ELF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELF2 Gene

Publications for ELF2 Gene

  1. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. (PMID: 8756667) Oettgen P. … Libermann T.A. (Mol. Cell. Biol. 1996) 2 3 4 23 67
  2. E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth. (PMID: 18544453) Qiu Y. … Aozasa K. (Exp. Mol. Pathol. 2008) 3 23
  3. E74-like factor 2 regulates valosin-containing protein expression. (PMID: 17368566) Zhang B. … Aozasa K. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. (PMID: 14970218) Cho J.-Y. … Libermann T.A. (J. Biol. Chem. 2004) 3 23
  5. NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia. (PMID: 11967990) Christensen R.A. … Varticovski L. (J. Cell. Biochem. 2002) 3 23

Products for ELF2 Gene

Sources for ELF2 Gene

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