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ELF2 Gene

protein-coding   GIFtS: 59
GCID: GC04M139978

E74-Like Factor 2 (Ets Domain Transcription Factor)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
E74-Like Factor 2 (Ets Domain Transcription Factor)1 2     NERF-22
New ETS-Related Factor2 3     Ets Family Transcription Factor ELF2C2
NERF2 3     ETS-Related Transcription Factor Elf-22
EU322     E74-Like Factor 23
NERF-1A2     BRUNOL35
NERF-1B2     CCUGBP25
NERF-1a,b2     ETR35

External Ids:    HGNC: 33171   Entrez Gene: 19982   Ensembl: ENSG000001093817   OMIM: 6025385   UniProtKB: Q157233   
ORGUL members:         

Export aliases for ELF2 gene to outside databases

Previous GC identifers: GC04M140884 GC04M140278 GC04M140445 GC04M140556 GC04M140336 GC04M140198 GC04M135708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ELF2 Gene:
ELF2 (E74-like factor 2 (ets domain transcription factor)) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ELF2_HUMAN, Q15723
Function: Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to
transactivate the BLK promoter
Function: Isoform 2 may function in repression of RUNX1-mediated transactivation

Gene Wiki entry for ELF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELF2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELF2 promoter sequence
   Search Chromatin IP Primers for ELF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q28

ELF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELF2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M139978:  view genomic region     (about GC identifiers)

Start:
139,949,266 bp from pter      End:
140,098,372 bp from pter
Size:
149,107 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ELF2_HUMAN, Q15723 (See protein sequence)
Recommended Name: ETS-related transcription factor Elf-2  
Size: 593 amino acids; 63967 Da
Subunit: Interacts with the LIM domains of LMO2 (By similarity). Interacts via its N-terminal region with RUNX1
Secondary accessions: Q15724 Q15725 Q6P1K5
Alternative splicing: 5 isoforms:  Q15723-5   Q15723-1   Q15723-2   Q15723-3   Q15723-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ELF2: NX_Q15723

Explore proteomics data for ELF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys244
  • Modification sites at PhosphoSitePlus

  • See ELF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001263386.1  NP_001263387.1  NP_001263388.1  NP_006865.1  NP_973728.1  

    ENSEMBL proteins: 
     ENSP00000377782   ENSP00000351458   ENSP00000426997   ENSP00000397796   ENSP00000426087  
     ENSP00000421278   ENSP00000368868   ENSP00000265495   ENSP00000368867  

    ELF2 Human Recombinant Protein Products:

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    Novus Biologicals ELF2 Proteins
    Novus Biologicals ELF2 Lysates
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    Cloud-Clone Corp. Proteins for ELF2

     
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    antibodies-online proteins for ELF2 (4 products) 

     
    antibodies-online peptides for ELF2

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    antibodies-online antibodies for ELF2 (18 products) 

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    antibodies-online kits for ELF2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000418 Ets_dom
     IPR022084 TF_Elf_N

    Graphical View of Domain Structure for InterPro Entry Q15723

    ProtoNet protein and cluster: Q15723

    UniProtKB/Swiss-Prot: ELF2_HUMAN, Q15723
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    Find genes that share domains with ELF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELF2_HUMAN, Q15723
    Function: Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to
    transactivate the BLK promoter
    Function: Isoform 2 may function in repression of RUNX1-mediated transactivation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA14970218
    GO:0005515protein binding IPI14970218
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ELF2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ELF2:
     Cells with protrusions  Decreased viability with pacli 

         1 MGI phenotypic allele for Elf2 (no phenotypes)

    Find genes that share phenotypes with ELF2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ELF2

    miRNA
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    hsa-miR-607 hsa-miR-300 hsa-miR-429 hsa-miR-200a hsa-miR-29a hsa-miR-105 hsa-miR-141 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidELF2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELF2_HUMAN, Q15723: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with ELF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    2ADP signalling through P2Y purinoceptor 12
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ELF2
        Development Angiopoietin - Tie2 signaling

    1 BioSystems Pathway for ELF2
        Angiopoietin receptor Tie2-mediated signaling

    1 PharmGKB Pathway for ELF2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELF2
    Interactions:

        GeneGlobe Interaction Network for ELF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for ELF2 (Q157231, 2, 3 ENSP000002654954) via UniProtKB, MINT, STRING, and/or I2D (see all 569)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUNX1Q011961, 3, ENSP000003003054EBI-956941,EBI-925904 I2D: score=4 STRING: ENSP00000300305
    EIF2AK2P195253, ENSP000002330574I2D: score=1 STRING: ENSP00000233057
    LMO2P257913, ENSP000002578184I2D: score=2 STRING: ENSP00000257818
    ZBTB32Q9Y2Y43, ENSP000002626304I2D: score=1 STRING: ENSP00000262630
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA14970218
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0030154cell differentiation IBA--

    Find genes that share ontologies with ELF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ELF2 gene (5 alternative transcripts): 
    NM_001276457.1  NM_001276458.1  NM_001276459.1  NM_006874.3  NM_201999.2  

    Unigene Cluster for ELF2:

    E74-like factor 2 (ets domain transcription factor)
    Hs.634040  [show with all ESTs]
    Unigene Representative Sequence: NM_201999
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515489 ENST00000394235(uc003ihp.1) ENST00000358635(uc003ihm.1 uc003ihn.1 uc003iho.1)
    ENST00000510408 ENST00000420916 ENST00000512627 ENST00000514577 ENST00000504314
    ENST00000514606(uc010ioh.3) ENST00000511184 ENST00000511006 ENST00000379550
    ENST00000265495 ENST00000379549(uc011chc.1)
    miRNA
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    hsa-miR-607 hsa-miR-300 hsa-miR-429 hsa-miR-200a hsa-miR-29a hsa-miR-105 hsa-miR-141 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidELF2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ELF2
      QuantiFast Probe-based Assays in human, mouse, rat ELF2

    Additional mRNA sequence: 

    AF256222.1 AF256223.1 AK301307.1 AK311505.1 AK316455.1 BC034951.1 BC065025.1 U43188.1 
    U43189.1 

    15 DOTS entries:

    DT.91763418  DT.456073  DT.91763428  DT.100702561  DT.91920081  DT.40232522  DT.97784693  DT.100731458 
    DT.121274253  DT.75164010  DT.100746098  DT.100773182  DT.95263465  DT.40189386  DT.75194303 

    Selected AceView cDNA sequences (see all 207):

    AI435042 AA281424 BX954881 AA086254 BM979780 AA431882 AI123584 AA280836 
    BQ892356 BE620515 CR603502 AA808094 CA950459 BM969346 BU674973 N23190 
    BM684235 BM712909 AW779952 BM719404 BQ027182 AA296451 BM991993 BU621268 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ELF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b
    SP1:                                                                                                                                    
    SP2:                                                                                -     -                                             
    SP3:                                                              -                 -     -                                             
    SP4:                          -     -     -     -                                                                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ELF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAGTGGG
    ELF2 Expression
    About this image


    ELF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ELF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.634040

    UniProtKB/Swiss-Prot: ELF2_HUMAN, Q15723
    Tissue specificity: Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of
    expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest
    levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary.
    Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain
    and peripheral blood lymphocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELF2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elf21 , 5 E74-like factor 21, 5 88.54(n)1
    92.23(a)1
      3 (22.19 cM)5
    692571  NM_023502.11  NP_075991.11 
     512556655 
    chicken
    (Gallus gallus)
    Aves ELF21 E74-like factor 2 (ets domain transcription factor) 80.26(n)
    85.2(a)
      422439  XM_004940937.1  XP_004940994.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELF26
    E74-like factor 2 (ets domain transcription factor...
    82(a)
    1 ↔ 1
    5(120389787-120418932)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193572 Xenopus laevis transcribed sequence with moderate similarity more 77.87(n)    48043460 
    zebrafish
    (Danio rerio)
    Actinopterygii elf22 E74-like factor 2 (ets domain transcription factor) 78.19(n)   387534  BC056554.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C24A1.23   -- 56(a)   III(706423-715521)   --


    ENSEMBL Gene Tree for ELF2 (if available)
    TreeFam Gene Tree for ELF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELF2 gene
    ELK42  ELF32  ELF42  ELF12  ELF52  ETV72  ELK12  ETV62  
    EHF2  SPDEF2  ELK32  
    8 SIMAP similar genes for ELF2 using alignment to 6 protein entries:     ELF2_HUMAN (see all proteins):
    ELK3    ETV1    ETV2    ELF5    EWSR1/FLI1 fusion    ELF1
    ELF4    DKFZp686H0575

    Find genes that share paralogs with ELF2           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ELF2
    PGOHUM00000240451 PGOHUM00000243040 PGOHUM00000236679 PGOHUM00000241484


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELF2 (see all 1469)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159732531,2
    F--139978471(+) TTACAA/GAGGGA 5 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1400144891,2
    --139978642(+) TTACAC/TAGTTT 5 -- ds50010--------
    rs1452118181,2
    C--139978879(+) AATATC/TAATAT 5 -- ut310--------
    rs1924433521,2
    --139979064(+) TTGAAA/GCAAGA 5 -- ut310--------
    rs559601321,2
    C--139979117(+) CTATTA/GTAGTT 5 -- ut310--------
    rs1509897821,2
    --139979138(+) CACTGC/GTATTT 5 -- ut310--------
    rs115560741,2
    C--139979170(+) AAAAAG/AAAAAA 5 -- ut311Minor allele frequency- A:0.00NA 2
    rs1138006391,2
    C--139979562(+) GTATG-/TATATAT 5 -- ut311Minor allele frequency- TA:0.00CSA 2
    rs774522371,2
    C--139979658(+) TTCTAA/CAATAC 5 -- ut310--------
    rs1837327241,2
    --139979860(+) TGATAC/TCGTAG 5 -- ut310--------

    HapMap Linkage Disequilibrium report for ELF2 (139949266 - 140098372 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ELF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv880160CNV Gain21882294
    esv275286CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELF2
    DNA2.0 Custom Variant and Variant Library Synthesis for ELF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602538    OMIM disorders: --


    Find genes that share disorders with ELF2           About GenesLikeMe

    Genetic Association Database (GAD): ELF2
    Human Genome Epidemiology (HuGE) Navigator: ELF2 (1 document)

    Export disorders for ELF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELF2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with ELF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. (PubMed id 8756667)1, 2, 3, 9 Oettgen P....Libermann T.A. (Mol. Cell. Biol. 1996)
    2. Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. (PubMed id 14970218)1, 2, 9 Cho J.-Y.... Libermann T.A. (J. Biol. Chem. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)1, 4 King J.K....Chen P.J. (Hepatology 2002)
    5. Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. (PubMed id 10207087)1, 2 Mao S.... Nimer S.D. (Mol. Cell. Biol. 1999)
    6. E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth. (PubMed id 18544453)1, 9 Qiu Y....Aozasa K. (Exp. Mol. Pathol. 2008)
    7. NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia. (PubMed id 11967990)1, 9 Christensen R.A....Varticovski L. (J. Cell. Biochem. 2002)
    8. E74-like factor 2 regulates valosin-containing protein expression. (PubMed id 17368566)1, 9 Zhang B....Aozasa K. (Biochem. Biophys. Res. Commun. 2007)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1998 HGNC: 3317 AceView: ELF2 Ensembl:ENSG00000109381 euGenes: HUgn1998
    ECgene: ELF2 H-InvDB: ELF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELF2 gene:
    Search GeneIP for patents involving ELF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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