External Ids for ELF1 Gene
Previous GeneCards Identifiers for ELF1 Gene
This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
GeneCards Summary for ELF1 Gene
ELF1 (E74-Like Factor 1 (Ets Domain Transcription Factor)) is a Protein Coding gene. Among its related pathways are Immune response IL-23 signaling pathway and IL2 signaling events mediated by PI3K. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ELF4.
UniProtKB/Swiss-Prot for ELF1 Gene
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.