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Aliases for ELF1 Gene

Aliases for ELF1 Gene

  • E74-Like Factor 1 (Ets Domain Transcription Factor) 2 3
  • E74-Like Factor 1 4

External Ids for ELF1 Gene

Summaries for ELF1 Gene

Entrez Gene Summary for ELF1 Gene

  • This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

GeneCards Summary for ELF1 Gene

ELF1 (E74-Like Factor 1 (Ets Domain Transcription Factor)) is a Protein Coding gene. Among its related pathways are Immune response IL-23 signaling pathway and IL2 signaling events mediated by PI3K. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELF1 Gene

  • Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF1 Gene

Genomics for ELF1 Gene

Genomic Location for ELF1 Gene

Start:
40,931,919 bp from pter
End:
41,061,440 bp from pter
Size:
129,522 bases
Orientation:
Minus strand

Genomic View for ELF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF1 Gene

Regulatory Elements for ELF1 Gene

Proteins for ELF1 Gene

  • Protein details for ELF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32519-ELF1_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-1
    Protein Accession:
    P32519
    Secondary Accessions:
    • B4E2I5
    • E9PDQ9
    • Q8N6F6
    • Q9UDE1

    Protein attributes for ELF1 Gene

    Size:
    619 amino acids
    Molecular mass:
    67498 Da
    Quaternary structure:
    • Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1.

    Alternative splice isoforms for ELF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELF1 Gene

Proteomics data for ELF1 Gene at MOPED

Post-translational modifications for ELF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys256, Lys290, and Lys571

Other Protein References for ELF1 Gene

No data available for DME Specific Peptides for ELF1 Gene

Domains for ELF1 Gene

Protein Domains for ELF1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ELF1_HUMAN
Domain:
  • Contains 1 ETS DNA-binding domain.:
    • P32519
Family:
  • Belongs to the ETS family.:
    • P32519
genes like me logo Genes that share domains with ELF1: view

No data available for Gene Families for ELF1 Gene

Function for ELF1 Gene

Molecular function for ELF1 Gene

GENATLAS Biochemistry: E74-like factor 1,ETS transcription regulator family,expressed in lymphoid and myeloid cells,binding to both the Ets binding sites (EBS1,EBS2) of IL2 enhancer,also binding to RB1 in resting normal T cells
UniProtKB/Swiss-Prot Function: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.

Gene Ontology (GO) - Molecular Function for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 8756667
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 8756667
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 14970218
GO:0005515 protein binding IPI 10207087
genes like me logo Genes that share ontologies with ELF1: view

Phenotypes for ELF1 Gene

genes like me logo Genes that share phenotypes with ELF1: view

Animal Models for ELF1 Gene

MGI Knock Outs for ELF1:

miRNA for ELF1 Gene

miRTarBase miRNAs that target ELF1
Targeting motifs for ELF1 Gene
HOMER Transcription Factor Regulatory Elements motif ELF1
  • Consensus sequence: AACCGGAAGT Submotif: canonical Cell Type: Jurkat GeoId: SRA014231

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for ELF1 Gene

Localization for ELF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELF1 Gene COMPARTMENTS Subcellular localization image for ELF1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19674970
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ELF1: view

Pathways for ELF1 Gene

genes like me logo Genes that share pathways with ELF1: view

Gene Ontology (GO) - Biological Process for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0030154 cell differentiation IBA --
GO:0045893 positive regulation of transcription, DNA-templated NAS 1527846
genes like me logo Genes that share ontologies with ELF1: view

Compounds for ELF1 Gene

(1) Novoseek inferred chemical compound relationships for ELF1 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 0.263 1
genes like me logo Genes that share compounds with ELF1: view

Transcripts for ELF1 Gene

Unigene Clusters for ELF1 Gene

E74-like factor 1 (ets domain transcription factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: -
SP7: -

Relevant External Links for ELF1 Gene

GeneLoc Exon Structure for
ELF1
ECgene alternative splicing isoforms for
ELF1

Expression for ELF1 Gene

mRNA expression in normal human tissues for ELF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELF1 Gene

SOURCE GeneReport for Unigene cluster for ELF1 Gene Hs.135646

mRNA Expression by UniProt/SwissProt for ELF1 Gene

P32519-ELF1_HUMAN
Tissue specificity: In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.
genes like me logo Genes that share expressions with ELF1: view

Orthologs for ELF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELF1 36
  • 99.78 (n)
  • 99.84 (a)
ELF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELF1 36
  • 87.62 (n)
  • 87.95 (a)
ELF1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELF1 36
  • 91.87 (n)
  • 92.57 (a)
ELF1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elf1 36
  • 87.67 (n)
  • 89.85 (a)
Elf1 16
Elf1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELF1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELF1 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elf1 36
  • 86.29 (n)
  • 87.48 (a)
chicken
(Gallus gallus)
Aves ELF1 36
  • 76.44 (n)
  • 77.2 (a)
ELF1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELF1 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia elf-1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia elf1 36
  • 70.31 (n)
  • 70.53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1074 36
zebrafish
(Danio rerio)
Actinopterygii ef1 36
  • 62.1 (n)
  • 60.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eip74EF 38
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea elf-1 37
  • 26 (a)
ManyToMany
ets-8 37
  • 34 (a)
ManyToMany
C24A1.2 38
  • 69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for ELF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELF1 Gene

ENSEMBL:
Gene Tree for ELF1 (if available)
TreeFam:
Gene Tree for ELF1 (if available)

Paralogs for ELF1 Gene

Paralogs for ELF1 Gene

Selected SIMAP similar genes for ELF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ELF1: view

Variants for ELF1 Gene

Sequence variations from dbSNP and Humsavar for ELF1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs7799 - 40,958,916(-) GCCCA(A/G)TGACA reference, missense
rs1028833 -- 41,039,590(-) AAAAC(A/C)TAGAA intron-variant
rs1028834 -- 41,039,570(-) AATTG(A/G)TCAAT intron-variant
rs1028835 -- 41,039,223(-) ggggt(A/T)ttgcc intron-variant
rs1056820 - 40,941,150(-) CCACT(A/T)CAGTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ELF1 Gene

Variant ID Type Subtype PubMed ID
nsv900012 CNV Loss 21882294
esv1709140 CNV Deletion 17803354
esv2747296 CNV Deletion 23290073
esv2747298 CNV Deletion 23290073
esv2672182 CNV Deletion 23128226
nsv64500 CNV Loss 16902084
esv259449 OTHER Complex 20981092
esv259991 OTHER Complex 20981092

Relevant External Links for ELF1 Gene

HapMap Linkage Disequilibrium report
ELF1

Disorders for ELF1 Gene

(8) Novoseek inferred disease relationships for ELF1 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 52.7 1
immunodeficiency 21.3 2
retinoblastoma 19.2 1
osteosarcoma 16.9 2
breast cancer 13.3 3

Relevant External Links for ELF1

Genetic Association Database (GAD)
ELF1
Human Genome Epidemiology (HuGE) Navigator
ELF1
Tumor Gene Database (TGDB):
ELF1
genes like me logo Genes that share disorders with ELF1: view

No data available for UniProtKB/Swiss-Prot for ELF1 Gene

Publications for ELF1 Gene

  1. Cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. (PMID: 1545787) Thompson C.B. … Karpinski B. (Mol. Cell. Biol. 1992) 2 3 4 23
  2. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. (PMID: 8756667) Oettgen P. … Libermann T.A. (Mol. Cell. Biol. 1996) 3 4 23
  3. Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF- 1. (PMID: 9524226) Aryee D.N.T. … Kovar H. (Gene 1998) 3 4 23
  4. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. (PMID: 8493578) Wang C.Y. … Leiden J.M. (Science 1993) 3 4 23
  5. A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. (PMID: 1527846) Leiden J.M. … Thompson C.B. (J. Virol. 1992) 3 4 23

Products for ELF1 Gene

Sources for ELF1 Gene

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