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ELF1 Gene

protein-coding   GIFtS: 61
GCID: GC13M041506

E74-Like Factor 1 (Ets Domain Transcription Factor)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E74-Like Factor 1 (Ets Domain Transcription Factor)1 2
ETS-Related Transcription Factor Elf-12
E74-Like Factor 13

External Ids:    HGNC: 33161   Entrez Gene: 19972   Ensembl: ENSG000001206907   OMIM: 1899735   UniProtKB: P325193   

Export aliases for ELF1 gene to outside databases

Previous GC identifers: GC13M039492 GC13M035492 GC13M040442 GC13M039304 GC13M040404 GC13M022305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELF1 Gene:
This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily
expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various
genes. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2009)

GeneCards Summary for ELF1 Gene:
ELF1 (E74-like factor 1 (ets domain transcription factor)) is a protein-coding gene. Diseases associated with ELF1 include retinoblastoma, and conjunctivitis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ELF1_HUMAN, P32519
Function: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the
T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs
in the HIV-2 enhancer




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELF1 gene promoter:
         C/EBPbeta   AP-1   p53   AML1a   GCNF   GATA-1   AREB6   FAC1   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELF1 promoter sequence
   Search Chromatin IP Primers for ELF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13   Ensembl cytogenetic band:  13q14.11   HGNC cytogenetic band: 13q13

ELF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELF1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M041506:  view genomic region     (about GC identifiers)

Start:
41,506,055 bp from pter      End:
41,635,576 bp from pter
Size:
129,522 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ELF1_HUMAN, P32519 (See protein sequence)
Recommended Name: ETS-related transcription factor Elf-1  
Size: 619 amino acids; 67498 Da
Subunit: Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to
regulate specific genes. Interacts with RUNX1
Secondary accessions: B4E2I5 E9PDQ9 Q8N6F6 Q9UDE1
Alternative splicing: 2 isoforms:  P32519-1   P32519-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ELF1: NX_P32519

Explore proteomics data for ELF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys256, Lys290, Lys571
  • Modification sites at PhosphoSitePlus

  • See ELF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138825.1  NP_758961.1  

    ENSEMBL proteins: 
     ENSP00000239882   ENSP00000384135   ENSP00000405580  

    ELF1 Human Recombinant Protein Products:

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    Novus Biologicals ELF1 Proteins
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ELF1

    ELF1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ELF1

    ELF1 Assay Products:

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    Cloud-Clone Corp. CLIAs for ELF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000418 Ets_dom
     IPR022084 TF_Elf_N

    Graphical View of Domain Structure for InterPro Entry P32519

    ProtoNet protein and cluster: P32519

    UniProtKB/Swiss-Prot: ELF1_HUMAN, P32519
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ELF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELF1_HUMAN, P32519
    Function: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the
    T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs
    in the HIV-2 enhancer

         Genatlas biochemistry entry for ELF1:
    E74-like factor 1,ETS transcription regulator family,expressed in lymphoid and myeloid cells,binding to both the
    Ets binding sites (EBS1,EBS2) of IL2 enhancer,also binding to RB1 in resting normal T cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA14970218
    GO:0005515protein binding IPI10207087
    GO:0043565sequence-specific DNA binding IEA--
         
    ELF1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Elf1):
     hematopoietic system  immune system  normal 

    ELF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ELF1: Elf1tm1Jni Elf1tm1Jml

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELF1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AACCGGAAGT 

    miRNA
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    miRTarBase miRNAs that target ELF1:
    hsa-mir-194-5p (MIRT044877)

    Block miRNA regulation of human, mouse, rat ELF1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ELF1:
    hsa-miR-3149 hsa-miR-3673 hsa-miR-205 hsa-miR-3684 hsa-miR-4282 hsa-miR-570 hsa-miR-494 hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidELF1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ELF1
    Predesigned siRNA for gene silencing in human, mouse, rat ELF1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): ELF1 (NM_001145353)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELF1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELF1_HUMAN, P32519: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----

    ELF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELF1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response IL 2 activation and signaling pathway
    Immune response IL 2 activation and signaling pathway0.41
    Immune response IL 3 activation and signaling pathway0.41
    2IL2 signaling events mediated by PI3K
    IL2 signaling events mediated by STAT50.34
    3Immune response IL 23 signaling pathway
    Angiopoietin receptor Tie2-mediated signaling0.32
    4Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for ELF1
        Immune response IL-3 activation and signaling pathway
    Immune response IL-2 activation and signaling pathway

    3 BioSystems Pathways for ELF1
        IL2 signaling events mediated by STAT5
    Regulation of retinoblastoma protein
    Angiopoietin receptor Tie2-mediated signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELF1
    Interactions:

        GeneGlobe Interaction Network for ELF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for ELF1 (P325191, 3 ENSP000002398824) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXC13P312761, 3, ENSP000002430564EBI-765526,EBI-2293590 I2D: score=2 STRING: ENSP00000243056
    SP1P080471, 3, ENSP000003293574EBI-765526,EBI-298336 I2D: score=4 STRING: ENSP00000329357
    HMGA1P170963, ENSP000003082274I2D: score=4 STRING: ENSP00000308227
    NFKB1P198383, ENSP000002265744I2D: score=4 STRING: ENSP00000226574
    NFYBP252083, ENSP000002400554I2D: score=2 STRING: ENSP00000240055
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001817regulation of cytokine production IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0030154cell differentiation IBA--

    ELF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELF1

    1 Novoseek inferred chemical compound relationship for ELF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 0.263 2 8642278 (1)



    ELF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ELF1 gene (2 alternative transcripts): 
    NM_001145353.1  NM_172373.3  

    Unigene Cluster for ELF1:

    E74-like factor 1 (ets domain transcription factor)
    Hs.135646  [show with all ESTs]
    Unigene Representative Sequence: NM_172373
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498824(uc010acd.3) ENST00000239882(uc001uxs.3) ENST00000405737
    ENST00000442101(uc010tfc.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat ELF1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ELF1:
    hsa-miR-3149 hsa-miR-3673 hsa-miR-205 hsa-miR-3684 hsa-miR-4282 hsa-miR-570 hsa-miR-494 hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidELF1 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for ELF1
    OriGene qSTAR qPCR primer pairs in human, mouse for ELF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELF1
      QuantiTect SYBR Green Assays in human, mouse, rat ELF1
      QuantiFast Probe-based Assays in human, mouse, rat ELF1

    Additional mRNA sequence: 

    AK095466.1 AK128315.1 AK304289.1 BC010575.1 BC030507.2 BX640798.1 M82882.1 

    21 DOTS entries:

    DT.100794736  DT.100647730  DT.218074  DT.95200477  DT.92426388  DT.92459824  DT.92459860  DT.91943192 
    DT.95306264  DT.101977774  DT.120779047  DT.100794735  DT.100794738  DT.120778975  DT.120779062  DT.120779070 
    DT.40113081  DT.95099446  DT.107440  DT.107441  DT.92009492 

    Selected AceView cDNA sequences (see all 305):

    BM564395 CR607135 BM853142 AA371474 BQ440688 AA313968 AI292088 BM128984 
    BM476393 W21019 BX119844 BC030507 AA707146 BC010575 CD675015 AA503233 
    BE349204 AA376665 AU185893 BM955872 BI962856 AJ712532 BE220155 AI034029 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ELF1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                    -     -     -           -                                                                     
    SP2:                    -     -     -           -                                                                     
    SP3:                    -     -                 -                                                                     
    SP4:                                                                                                                  
    SP5:                    -     -     -                                                                                 


    ECgene alternative splicing isoforms for ELF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELF1 expression in normal human tissues (normalized intensities)      ELF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAATTGGA
    ELF1 Expression
    About this image


    ELF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
    ELF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.135646

    UniProtKB/Swiss-Prot: ELF1_HUMAN, P32519
    Tissue specificity: In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed
    in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed
    at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and
    colon, and weakly expressed in brain and testis

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    QuantiTect SYBR Green Assays in human, mouse, rat ELF1
    QuantiFast Probe-based Assays in human, mouse, rat ELF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELF1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elf11 , 5 E74-like factor 11, 5 87.67(n)1
    89.85(a)1
      14 (42.67 cM)5
    137091  NM_001286411.11  NP_001273340.11 
     794811945 
    chicken
    (Gallus gallus)
    Aves ELF11 E74-like factor 1 (ets domain transcription factor) 76.44(n)
    77.2(a)
      418828  NM_001006269.1  NP_001006269.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELF16
    E74-like factor 1 (ets domain transcription factor...
    66(a)
    1 ↔ 1
    3(70733357-70767463)
    African clawed frog
    (Xenopus laevis)
    Amphibia elf-1-prov2 E74-like factor 1 (ets domain transcription factor) 76.45(n)    BC044973.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ef11 ETS-related factor1 62.1(n)
    60.62(a)
      30396  NM_131159.1  NP_571234.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C24A1.23   -- 69(a)   III(706423-715521)   --


    ENSEMBL Gene Tree for ELF1 (if available)
    TreeFam Gene Tree for ELF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELF1 gene
    ELK42  ELF32  ELF42  ELF52  ETV72  ELK12  ETV62  EHF2  
    ELF22  SPDEF2  ELK32  
    4 SIMAP similar genes for ELF1 using alignment to 3 protein entries:     ELF1_HUMAN (see all proteins):
    DKFZp686H0575    ELF5    ELF4    ELF2

    ELF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELF1 (see all 1768)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558045761,2
    C--22479982(+) TACTT-/CTGTCAT 2 -- int12Minor allele frequency- CT:0.25NA 4
    rs95254291,2
    C,F,H--41505574(+) AACTAT/CTAACT 2 -- ds500123Minor allele frequency- C:0.04NS EA NA WA CSA 2073
    rs1872521361,2
    --41505602(+) GAAAAC/TTTGTT 2 -- ds50010--------
    rs95326741,2
    C,F,A--41505766(+) GCTGGG/ATGTGG 2 -- ds50013Minor allele frequency- A:0.50NA CSA 6
    rs95666241,2
    C--41505773(+) GTGGTC/GGTGGG 2 -- ds50010--------
    rs111478281,2
    C,F,A--41505863(+) GGTCAC/TGCCAC 2 -- ds50018Minor allele frequency- T:0.47NA WA CSA EA 252
    rs1894198651,2
    --41505883(+) GCCTGA/GGTGAC 2 -- ds50010--------
    rs1442672121,2
    --41505923(+) CAAAAC/TAAAAG 2 -- ds50010--------
    rs1119009811,2
    C,F--41505945(+) TTATTG/TCTGGG 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1478092511,2
    --41505976(+) TTTTTA/GCAACT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ELF1 (41506055 - 41635576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ELF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672182CNV Deletion23128226
    esv1709140CNV Deletion17803354
    esv2747296CNV Deletion23290073
    esv2747298CNV Deletion23290073
    nsv900012CNV Loss21882294
    nsv64500CNV Loss16902084
    esv259449OTHER Complex20981092
    esv259991OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189973    OMIM disorders: --

    17 diseases for ELF1:    About MalaCards
    retinoblastoma    conjunctivitis    burkitt's lymphoma    osteosarcoma
    t-cell leukemia    endometrial carcinoma    systemic lupus erythematosus    acute myeloid leukemia
    lupus erythematosus    leukemia    crohn's disease    myeloid leukemia
    prostate cancer    prostatitis    endotheliitis    breast cancer
    lung cancer


    ELF1 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for ELF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 52.7 1 8350410 (1)
    immunodeficiency 21.3 2 1527846 (1), 8702655 (1)
    retinoblastoma 19.2 1 8493578 (1)
    osteosarcoma 16.9 2 12883651 (1), 12798703 (1)
    breast cancer 13.3 3 12883651 (1), 12798703 (1), 11175365 (1)
    prostate cancer 3.39 2 12883651 (1), 12798703 (1)
    tumors 0 3 12883651 (1), 19624906 (1), 12798703 (1)
    cancer 0 2 11334730 (1)

    Genetic Association Database (GAD): ELF1
    Human Genome Epidemiology (HuGE) Navigator: ELF1 (2 documents)
    Tumor Gene Database (TGDB): ELF1

    Export disorders for ELF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELF1 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with ELF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. (PubMed id 1545787)1, 2, 3, 9 Thompson C.B.... Karpinski B. (Mol. Cell. Biol. 1992)
    2. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. (PubMed id 8756667)1, 2, 9 Oettgen P....Libermann T.A. (Mol. Cell. Biol. 1996)
    3. A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. (PubMed id 1527846)1, 2, 9 Leiden J.M....Thompson C.B. (J. Virol. 1992)
    4. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. (PubMed id 8493578)1, 2, 9 Wang C.Y.... Leiden J.M. (Science 1993)
    5. Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF- 1. (PubMed id 9524226)1, 2, 9 Aryee D.N.T.... Kovar H. (Gene 1998)
    6. ELF1 is associated with systemic lupus erythematosus in Asian populations. (PubMed id 21044949)1, 4 Yang J....Lau Y.L. (Hum. Mol. Genet. 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. (PubMed id 10207087)1, 2 Mao S.... Nimer S.D. (Mol. Cell. Biol. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1997 HGNC: 3316 AceView: ELF1 Ensembl:ENSG00000120690 euGenes: HUgn1997
    ECgene: ELF1 H-InvDB: ELF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELF1 gene:
    Search GeneIP for patents involving ELF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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