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Aliases for ELF1 Gene

Aliases for ELF1 Gene

  • E74 Like ETS Transcription Factor 1 2 3 5
  • E74-Like Factor 1 (Ets Domain Transcription Factor) 2 3
  • ETS-Related Transcription Factor Elf-1 3
  • E74-Like Factor 1 4
  • EFTUD1 3
  • RIA1 3

External Ids for ELF1 Gene

Previous GeneCards Identifiers for ELF1 Gene

  • GC13M039492
  • GC13M035492
  • GC13M040442
  • GC13M039304
  • GC13M040404
  • GC13M041506
  • GC13M022305

Summaries for ELF1 Gene

Entrez Gene Summary for ELF1 Gene

  • This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

GeneCards Summary for ELF1 Gene

ELF1 (E74 Like ETS Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Immune response IL-23 signaling pathway and IL2 signaling events mediated by PI3K. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELF1 Gene

  • Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.

Additional gene information for ELF1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF1 Gene

Genomics for ELF1 Gene

Regulatory Elements for ELF1 Gene

Enhancers for ELF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H040972 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.8 +81.7 81716 15 PKNOX1 FOXA2 ATF1 ARNT FEZF1 YY1 TCF12 GATA2 ZNF143 ATF7 ELF1 WBP4 CYCSP34 SUGT1P3 RGCC NAA16 FOXO1 RGS17P1 PIR56183
GH13H041014 1.7 FANTOM5 ENCODE dbSUPER 15.2 +43.3 43310 8 ATF1 FOXA2 ARNT SIN3A ZNF2 YY1 FOS ATF7 RUNX3 JUNB WBP4 ELF1 SLC25A15 RGCC NAA16 GC13M041023 RGS17P1
GH13H041001 1.6 Ensembl ENCODE dbSUPER 12.5 +56.1 56099 8 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 TCF12 SLC30A9 FOS WBP4 ELF1 NAA16 CYCSP34 SLC25A15 RGS17P1 GC13M041023
GH13H040991 1.3 Ensembl ENCODE dbSUPER 11.7 +66.9 66899 5 CTCF ESRRA ZFP64 SIN3A MAX EBF1 RAD21 ZNF7 CTBP1 ZNF316 WBP4 ELF1 CYCSP34 SLC25A15 RGS17P1 GC13M041023
GH13H040770 1.2 ENCODE 12 +290.3 290344 1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SSRP1 ZNF610 LINC00548 KBTBD6 MORF4L1P4 ELF1 FOXO1 SUGT1P3 NAA16 SLC25A15 MRPS31 ENSG00000277794
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELF1 on UCSC Golden Path with GeneCards custom track

Promoters for ELF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000061756 440 4001 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZNF610 ZNF585B GLIS1

Genomic Location for ELF1 Gene

Chromosome:
13
Start:
40,931,919 bp from pter
End:
41,061,440 bp from pter
Size:
129,522 bases
Orientation:
Minus strand

Genomic View for ELF1 Gene

Genes around ELF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF1 Gene

Proteins for ELF1 Gene

  • Protein details for ELF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32519-ELF1_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-1
    Protein Accession:
    P32519
    Secondary Accessions:
    • B4E2I5
    • E9PDQ9
    • Q8N6F6
    • Q9UDE1

    Protein attributes for ELF1 Gene

    Size:
    619 amino acids
    Molecular mass:
    67498 Da
    Quaternary structure:
    • Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1.

    Alternative splice isoforms for ELF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELF1 Gene

Post-translational modifications for ELF1 Gene

  • Ubiquitination at posLast=571571
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ELF1 Gene

Domains & Families for ELF1 Gene

Gene Families for ELF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ELF1 Gene

Suggested Antigen Peptide Sequences for ELF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32519

UniProtKB/Swiss-Prot:

ELF1_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELF1: view

Function for ELF1 Gene

Molecular function for ELF1 Gene

GENATLAS Biochemistry:
E74-like factor 1,ETS transcription regulator family,expressed in lymphoid and myeloid cells,binding to both the Ets binding sites (EBS1,EBS2) of IL2 enhancer,also binding to RB1 in resting normal T cells
UniProtKB/Swiss-Prot Function:
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.

Phenotypes From GWAS Catalog for ELF1 Gene

Gene Ontology (GO) - Molecular Function for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 8756667
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 8756667
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA,IEA 14970218
GO:0005515 protein binding IPI 10207087
genes like me logo Genes that share ontologies with ELF1: view
genes like me logo Genes that share phenotypes with ELF1: view

Animal Models for ELF1 Gene

MGI Knock Outs for ELF1:

Animal Model Products

CRISPR Products

miRNA for ELF1 Gene

miRTarBase miRNAs that target ELF1
Targeted motifs for ELF1 Gene
HOMER Transcription Factor Regulatory Elements motif ELF1
  • Consensus sequence: AACCGGAAGT Submotif: canonical Cell Type: Jurkat GEO ID: SRA014231

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ELF1
  • Applied Biological Materials Clones for ELF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ELF1 Gene

Localization for ELF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELF1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19674970
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ELF1: view

Pathways & Interactions for ELF1 Gene

genes like me logo Genes that share pathways with ELF1: view

Gene Ontology (GO) - Biological Process for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IEA --
GO:0001959 regulation of cytokine-mediated signaling pathway TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ELF1: view

No data available for SIGNOR curated interactions for ELF1 Gene

Drugs & Compounds for ELF1 Gene

(1) Additional Compounds for ELF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELF1: view

Transcripts for ELF1 Gene

Unigene Clusters for ELF1 Gene

E74-like factor 1 (ets domain transcription factor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ELF1
  • Applied Biological Materials Clones for ELF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ELF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: -
SP7: -

Relevant External Links for ELF1 Gene

GeneLoc Exon Structure for
ELF1
ECgene alternative splicing isoforms for
ELF1

Expression for ELF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELF1 Gene

This gene is overexpressed in CD8 Tcells (25.1), Peripheral blood mononuclear cells (11.8), Blymphocyte (9.9), and NK cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ELF1 Gene



Protein tissue co-expression partners for ELF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELF1 Gene:

ELF1

SOURCE GeneReport for Unigene cluster for ELF1 Gene:

Hs.135646

mRNA Expression by UniProt/SwissProt for ELF1 Gene:

P32519-ELF1_HUMAN
Tissue specificity: In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.

Evidence on tissue expression from TISSUES for ELF1 Gene

  • Liver(4.3)
  • Nervous system(2.5)
  • Spleen(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with ELF1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELF1 Gene

Orthologs for ELF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELF1 34 33
  • 99.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ELF1 33 34
  • 91.87 (n)
mouse
(Mus musculus)
Mammalia Elf1 33 16 34
  • 87.67 (n)
cow
(Bos Taurus)
Mammalia ELF1 34 33
  • 87.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elf1 33
  • 86.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ELF1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELF1 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELF1 33 34
  • 76.44 (n)
lizard
(Anolis carolinensis)
Reptilia ELF1 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elf1 33
  • 70.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia elf-1-prov 33
zebrafish
(Danio rerio)
Actinopterygii ef1 33
  • 62.1 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1074 33
fruit fly
(Drosophila melanogaster)
Insecta Eip74EF 35
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea C24A1.2 35
  • 69 (a)
ets-8 34
  • 34 (a)
ManyToMany
elf-1 34
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
Species where no ortholog for ELF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELF1 Gene

ENSEMBL:
Gene Tree for ELF1 (if available)
TreeFam:
Gene Tree for ELF1 (if available)

Paralogs for ELF1 Gene

Paralogs for ELF1 Gene

(4) SIMAP similar genes for ELF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ELF1: view

Variants for ELF1 Gene

Sequence variations from dbSNP and Humsavar for ELF1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000010532 -- 41,034,609(+) GTACT(-/AA)GATTA intron-variant
rs1000031246 -- 41,058,727(+) TAGCA(A/C)TTTGG intron-variant
rs1000037688 -- 40,966,715(+) TGTTT(A/T)CCAAG intron-variant
rs1000038690 -- 40,946,570(+) AGTTA(C/T)ATCAA intron-variant
rs1000039882 -- 41,015,262(+) ATATG(A/G)CAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELF1 Gene

Variant ID Type Subtype PubMed ID
dgv986e59 CNV tandem duplication 20981092
esv1709140 CNV deletion 17803354
esv2672182 CNV deletion 23128226
esv2747296 CNV deletion 23290073
esv2747298 CNV deletion 23290073
esv3373421 CNV duplication 20981092
nsv561538 CNV loss 21841781
nsv64500 CNV deletion 16902084
nsv952542 CNV duplication 24416366

Variation tolerance for ELF1 Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.00; 97.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELF1 Gene

Disorders for ELF1 Gene

Relevant External Links for ELF1

Genetic Association Database (GAD)
ELF1
Human Genome Epidemiology (HuGE) Navigator
ELF1
Tumor Gene Database (TGDB):
ELF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELF1

No disorders were found for ELF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELF1 Gene

Publications for ELF1 Gene

  1. cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. (PMID: 1545787) Thompson CB … Karpinski B (Molecular and cellular biology 1992) 2 3 4 22 60
  2. Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1. (PMID: 9524226) Aryee DN … Kovar H (Gene 1998) 3 4 22 60
  3. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. (PMID: 8756667) Oettgen P … Libermann TA (Molecular and cellular biology 1996) 3 4 22 60
  4. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. (PMID: 8493578) Wang CY … Leiden JM (Science (New York, N.Y.) 1993) 3 4 22 60
  5. A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. (PMID: 1527846) Leiden JM … Thompson CB (Journal of virology 1992) 3 4 22 60

Products for ELF1 Gene

  • Addgene plasmids for ELF1

Sources for ELF1 Gene

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