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Aliases for ELAVL4 Gene

Aliases for ELAVL4 Gene

  • ELAV Like Neuron-Specific RNA Binding Protein 4 2 3
  • PNEM 3 4 6
  • HUD 3 4 6
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D) 2 3
  • Paraneoplastic Encephalomyelitis Antigen HuD 3 4
  • Hu Antigen D 2 3
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 2
  • ELAV-Like Protein 4 3
  • Hu-Antigen D 4

External Ids for ELAVL4 Gene

Previous HGNC Symbols for ELAVL4 Gene

  • HUD

Previous GeneCards Identifiers for ELAVL4 Gene

  • GC01P050199
  • GC01P049460
  • GC01P049928
  • GC01P049941
  • GC01P050283
  • GC01P050347
  • GC01P050513
  • GC01P048632

Summaries for ELAVL4 Gene

GeneCards Summary for ELAVL4 Gene

ELAVL4 (ELAV Like Neuron-Specific RNA Binding Protein 4) is a Protein Coding gene. Diseases associated with ELAVL4 include paraneoplastic neurologic disorders and lung cancer. GO annotations related to this gene include RNA binding and mRNA 3-UTR binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for ELAVL4 Gene

  • May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.

Gene Wiki entry for ELAVL4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL4 Gene

Genomics for ELAVL4 Gene

Regulatory Elements for ELAVL4 Gene

Genomic Location for ELAVL4 Gene

Start:
50,048,014 bp from pter
End:
50,203,786 bp from pter
Size:
155,773 bases
Orientation:
Plus strand

Genomic View for ELAVL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELAVL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL4 Gene

Proteins for ELAVL4 Gene

  • Protein details for ELAVL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26378-ELAV4_HUMAN
    Recommended name:
    ELAV-like protein 4
    Protein Accession:
    P26378
    Secondary Accessions:
    • B1APY6
    • B1APY7
    • B7Z4G7
    • Q8IYD4
    • Q96J74
    • Q96J75
    • Q9UD24

    Protein attributes for ELAVL4 Gene

    Size:
    380 amino acids
    Molecular mass:
    41770 Da
    Quaternary structure:
    • Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP.

    Three dimensional structures from OCA and Proteopedia for ELAVL4 Gene

    Alternative splice isoforms for ELAVL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELAVL4 Gene

Proteomics data for ELAVL4 Gene at MOPED

Post-translational modifications for ELAVL4 Gene

  • Methylation at Arg-243 by CARM1 weakens protective binding to the 3-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).
  • Ubiquitination at Lys81, Lys102, and Lys118
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ELAVL4 Gene

Domains for ELAVL4 Gene

Gene Families for ELAVL4 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

P26378

UniProtKB/Swiss-Prot:

ELAV4_HUMAN :
  • P26378
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL4: view

Function for ELAVL4 Gene

Molecular function for ELAVL4 Gene

GENATLAS Biochemistry: Drosophila Elav-like 4 (embryonic,lethal,abnormal vision),neural specific,expressed in brain,identified using sera from patients with a paraplastic multifocal neurologic disorder,homologous to HD,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded
UniProtKB/Swiss-Prot Function: May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.

Gene Ontology (GO) - Molecular Function for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 1655278
GO:0003729 mRNA binding --
GO:0003730 mRNA 3-UTR binding TAS 10848602
genes like me logo Genes that share ontologies with ELAVL4: view
genes like me logo Genes that share phenotypes with ELAVL4: view

Animal Models for ELAVL4 Gene

MGI Knock Outs for ELAVL4:

Animal Model Products

CRISPR Products

miRNA for ELAVL4 Gene

miRTarBase miRNAs that target ELAVL4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAVL4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ELAVL4 Gene

Localization for ELAVL4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELAVL4 Gene COMPARTMENTS Subcellular localization image for ELAVL4 gene
Compartment Confidence
nucleus 3
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ELAVL4 Gene

Pathways for ELAVL4 Gene

SuperPathways for ELAVL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 1655278
GO:0006397 mRNA processing TAS 10348344
genes like me logo Genes that share ontologies with ELAVL4: view

No data available for Pathways by source for ELAVL4 Gene

Compounds for ELAVL4 Gene

(2) Novoseek inferred chemical compound relationships for ELAVL4 Gene

Compound -log(P) Hits PubMed IDs
poly u 56.2 2
adenylate 0.441 4
genes like me logo Genes that share compounds with ELAVL4: view

Transcripts for ELAVL4 Gene

Unigene Clusters for ELAVL4 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAVL4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: -
SP7: - -
SP8:
SP9: - - -
SP10:

Relevant External Links for ELAVL4 Gene

GeneLoc Exon Structure for
ELAVL4
ECgene alternative splicing isoforms for
ELAVL4

Expression for ELAVL4 Gene

mRNA expression in normal human tissues for ELAVL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (11.3), Brain - Anterior cingulate cortex (BA24) (8.6), Brain - Cortex (6.5), Brain - Hypothalamus (5.2), and Brain - Hippocampus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ELAVL4 Gene

SOURCE GeneReport for Unigene cluster for ELAVL4 Gene Hs.213050

mRNA Expression by UniProt/SwissProt for ELAVL4 Gene

P26378-ELAV4_HUMAN
Tissue specificity: Brain
genes like me logo Genes that share expressions with ELAVL4: view

In Situ Assay Products

Orthologs for ELAVL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELAVL4 35
  • 99.36 (n)
  • 99.45 (a)
ELAVL4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELAVL4 35
  • 96.36 (n)
  • 99.73 (a)
ELAVL4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELAVL4 35
  • 95.35 (n)
  • 98.68 (a)
ELAVL4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elavl4 35
  • 94.08 (n)
  • 99.18 (a)
Elavl4 16
Elavl4 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELAVL4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL4 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elavl4 35
  • 94.91 (n)
  • 99.73 (a)
chicken
(Gallus gallus)
Aves ELAVL4 35
  • 87.7 (n)
  • 97.81 (a)
ELAVL4 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELAVL4 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia elrD 35
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl4 35
  • 84.88 (n)
  • 98.09 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
elavl4 35
  • 82.23 (n)
  • 95.88 (a)
elavl4 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta elav 36
  • 40 (a)
ManyToMany
fne 36
  • 59 (a)
ManyToMany
Rbp9 35
  • 62.2 (n)
  • 65.01 (a)
Rbp9 36
  • 50 (a)
ManyToMany
EG:132E8.1 37
  • 43 (a)
fne 37
  • 57 (a)
Sxl 37
  • 46 (a)
elav 37
  • 52 (a)
CG5213 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea exc-7 35
  • 54.05 (n)
  • 57.73 (a)
exc-7 36
  • 43 (a)
OneToMany
exc-7 37
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 36
  • 55 (a)
OneToMany
Species with no ortholog for ELAVL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL4 Gene

ENSEMBL:
Gene Tree for ELAVL4 (if available)
TreeFam:
Gene Tree for ELAVL4 (if available)

Paralogs for ELAVL4 Gene

Selected SIMAP similar genes for ELAVL4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ELAVL4: view

Variants for ELAVL4 Gene

Sequence variations from dbSNP and Humsavar for ELAVL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs913858 -- 50,192,398(-) AGAAT(A/G)GGTCT intron-variant
rs967582 -- 50,116,500(-) TACTT(G/T)AGAAG intron-variant
rs967583 -- 50,116,417(-) CACAC(A/G)CACGC intron-variant
rs1018670 -- 50,171,882(+) GATTA(C/T)TGCCA intron-variant
rs1329965 -- 50,193,337(+) AAGGA(A/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL4 Gene

Variant ID Type Subtype PubMed ID
nsv810 CNV Loss 18451855
esv2665070 CNV Deletion 23128226
nsv498670 CNV Loss 21111241
nsv829826 CNV Gain 17160897

Relevant External Links for ELAVL4 Gene

HapMap Linkage Disequilibrium report
ELAVL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL4 Gene

Disorders for ELAVL4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ELAVL4 Gene including...

Search for ELAVL4 Gene in MalaCards »

(12) Novoseek inferred disease relationships for ELAVL4 Gene

Disease -log(P) Hits PubMed IDs
paraneoplastic encephalomyelitis 95.7 16
sensory neuropathy 74.5 2
small cell lung cancer 68.9 9
cancer lung 52.1 12
paraneoplastic syndromes 49.2 1

Relevant External Links for ELAVL4

Genetic Association Database (GAD)
ELAVL4
Human Genome Epidemiology (HuGE) Navigator
ELAVL4
genes like me logo Genes that share disorders with ELAVL4: view

No data available for UniProtKB/Swiss-Prot for ELAVL4 Gene

Publications for ELAVL4 Gene

  1. Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. (PMID: 8222755) Muresu R. … Siniscalco M. (Cytogenet. Cell Genet. 1994) 2 3 23
  2. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. (PMID: 1655278) Szabo A. … Furneaux H.M. (Cell 1991) 3 4 23
  3. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'- untranslated regions using a novel ELISA-based assay. (PMID: 10710437) King P.H. (Nucleic Acids Res. 2000) 3 4 23
  4. Structural basis for recognition of AU-rich element RNA by the HuD protein. (PMID: 11175903) Wang X. … Tanaka Hall T.M. (Nat. Struct. Biol. 2001) 3 4 23
  5. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PMID: 12209604) Behrends U. … Mautner J.M. (Int. J. Cancer 2002) 3 4 23

Products for ELAVL4 Gene

Sources for ELAVL4 Gene

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