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ELAVL4 Gene

protein-coding   GIFtS: 61
GCID: GC01P050513

ELAV Like Neuron-Specific RNA Binding Protein 4

(Previous names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like...)
(Previous symbol: HUD)
  See ELAVL4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ELAV Like Neuron-Specific RNA Binding Protein 41 2     Paraneoplastic Encephalomyelitis Antigen HuD2 3
HUD1 2 3 5     ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 41
PNEM2 3 5     ELAV-Like Protein 42
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D)1 2     Embryonic Lethal, Abnormal Vision, Drosophila, Homolog Of, Like-42
Hu Antigen D1 2     HuD3
Hu-Antigen D2 3     

External Ids:    HGNC: 33151   Entrez Gene: 19962   Ensembl: ENSG000001623747   OMIM: 1683605   UniProtKB: P263783   

Export aliases for ELAVL4 gene to outside databases

Previous GC identifers: GC01P050199 GC01P049460 GC01P049928 GC01P049941 GC01P050283 GC01P050347 GC01P048632


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ELAVL4 Gene:
ELAVL4 (ELAV like neuron-specific RNA binding protein 4) is a protein-coding gene. Diseases associated with ELAVL4 include neuropathy, paraneoplastic sensory, and encephalomyelitis. GO annotations related to this gene include mRNA 3'-UTR binding and RNA binding. An important paralog of this gene is PABPC1L.

UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
Function: May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its
3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA

Gene Wiki entry for ELAVL4 (HuD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELAVL4 gene promoter:
         E2F-3a   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELAVL4 promoter sequence
   Search Chromatin IP Primers for ELAVL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELAVL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34

ELAVL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELAVL4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P050513:  view genomic region     (about GC identifiers)

Start:
50,513,686 bp from pter      End:
50,669,458 bp from pter
Size:
155,773 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378 (See protein sequence)
Recommended Name: ELAV-like protein 4  
Size: 380 amino acids; 41770 Da
Subunit: Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity)
2 PDB 3D structures from and Proteopedia for ELAVL4:
1FXL (3D)        1G2E (3D)    
Secondary accessions: B1APY6 B1APY7 B7Z4G7 Q8IYD4 Q96J74 Q96J75 Q9UD24
Alternative splicing: 5 isoforms:  P26378-1   P26378-2   P26378-3   P26378-4   P26378-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ELAVL4: NX_P26378

Explore proteomics data for ELAVL4 at MOPED

Post-translational modifications: 

  • Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A
    protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which
    facilitates neurite outgrowth (By similarity)1
  • Ubiquitination2 at Lys81, Lys102, Lys118
  • Modification sites at PhosphoSitePlus

  • See ELAVL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138246.1  NP_001138247.1  NP_001138248.1  NP_001138249.1  NP_068771.2  

    ENSEMBL proteins: 
     ENSP00000360892   ENSP00000349594   ENSP00000360889   ENSP00000360888   ENSP00000360886  
     ENSP00000360884   ENSP00000399939  

    ELAVL4 Human Recombinant Protein Products:

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    Novus Biologicals ELAVL4 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ELAVL4

     
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    antibodies-online proteins for ELAVL4 (7 products) 

     
    antibodies-online peptides for ELAVL4

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    ELAVL4 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR000504 RRM_dom
     IPR006548 ELAD_HUD_SF
     IPR002343 Hud_Sxl_RNA
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P26378

    ProtoNet protein and cluster: P26378

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002343 Paraneoplastic encephalomyelitis antigen family signature


    UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
    Similarity: Belongs to the RRM elav family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Find genes that share domains with ELAVL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELAV4_HUMAN, P26378
    Function: May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its
    3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA

         Genatlas biochemistry entry for ELAVL4:
    Drosophila Elav-like 4 (embryonic,lethal,abnormal vision),neural specific,expressed in brain,identified using sera
    from patients with a paraplastic multifocal neurologic disorder,homologous to HD,shuttling the ERG class of mRNA
    to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS1655278
    GO:0003730mRNA 3'-UTR binding TAS10848602
    GO:0017091AU-rich element binding IDA10710437
         
    Find genes that share ontologies with ELAVL4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ELAVL4:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Elavl4):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging  nervous system 
     reproductive system 

    Find genes that share phenotypes with ELAVL4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Elavl4tm1Okn for ELAVL4

       genOway: Develop your customized and physiologically relevant rodent model for ELAVL4

    miRNA
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    miRTarBase miRNAs that target ELAVL4:
    hsa-mir-21-5p (MIRT030948), hsa-mir-141-3p (MIRT021646), hsa-mir-375 (MIRT005543)

    Block miRNA regulation of human, mouse, rat ELAVL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELAVL4 (see all 45):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-4307 hsa-miR-429 hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidELAVL4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ELAVL4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELAVL4
    Interactions:

        GeneGlobe Interaction Network for ELAVL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ELAVL4 (P263782, 3 ENSP000003495944) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU93, ENSP000002941724I2D: score=1 STRING: ENSP00000294172
    ELAVL2Q129263, ENSP000003694604I2D: score=1 STRING: ENSP00000369460
    NFX1Q129863, ENSP000003688564I2D: score=1 STRING: ENSP00000368856
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    IGF2BP1Q9NZI83I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing TAS1655278
    GO:0006397mRNA processing TAS10348344

    Find genes that share ontologies with ELAVL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELAVL4 (ELAV4)

    2 Novoseek inferred chemical compound relationships for ELAVL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly u 56.2 2 12900401 (1), 17234598 (1)
    adenylate 0.441 4 12034726 (3), 17234598 (1)



    Find genes that share compounds with ELAVL4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ELAVL4 gene (5 alternative transcripts): 
    NM_001144774.1  NM_001144775.1  NM_001144776.1  NM_001144777.1  NM_021952.3  

    Unigene Cluster for ELAVL4:

    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4
    Hs.213050  [show with all ESTs]
    Unigene Representative Sequence: BC036071
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371827(uc001crz.3) ENST00000463650 ENST00000357083 ENST00000371824(uc001csb.2 uc001csc.3)
    ENST00000371823 ENST00000371821 ENST00000371819(uc009vyu.3 uc010omz.2)
    ENST00000494555 ENST00000492299 ENST00000474675 ENST00000448907(uc001cry.3 uc001csa.3)

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    Selected qRT-PCR Assays for microRNAs that regulate ELAVL4 (see all 45):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-4307 hsa-miR-429 hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidELAVL4 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ELAVL4

    Additional mRNA sequence: 

    AK297338.1 AK298817.1 AK298902.1 AK309653.1 AY033995.1 AY033996.1 AY033997.1 AY033998.1 
    BC036071.1 BX648050.1 M62843.1 S73887.1 

    10 DOTS entries:

    DT.312181  DT.410852  DT.92417808  DT.95371093  DT.40212820  DT.455326  DT.101966995  DT.121377620 
    DT.121377635  DT.91897490 

    Selected AceView cDNA sequences (see all 83):

    BX106243 AW088230 AY033997 CA772196 AU100542 AW665788 AA975446 AY033996 
    AA211071 BM669192 AW341000 T16673 AY033995 CR613627 CR625475 BQ720948 
    CR595508 T28890 BM693606 BM711406 AV725356 BX464139 BM716630 NM_021952 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL4 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:              -     -     -     -     -                       -                                   -         
    SP2:                    -     -     -     -                       -                                             
    SP3:                    -     -     -     -                       -                                   -         
    SP4:        -     -     -     -     -     -                       -                                   -         
    SP5:                                      -                       -                                             


    ECgene alternative splicing isoforms for ELAVL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELAVL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTTATAA
    ELAVL4 Expression
    About this image


    ELAVL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Endothelial Cells Blood Brain Barrier
             Thalamus
             Neural progenitor cells
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
    ELAVL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELAVL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.213050

    UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
    Tissue specificity: Brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELAVL4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elavl41 , 5 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more1, 5 94.08(n)1
    99.18(a)1
      4 (51.42 cM)5
    155721  NM_001163399.11  NP_001156871.11 
     1102037225 
    chicken
    (Gallus gallus)
    Aves ELAVL41 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 87.7(n)
    97.81(a)
      395634  NM_204830.1  NP_990161.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELAVL46
    ELAV like neuron-specific RNA binding protein 4
    94(a)
    1 ↔ 1
    4(113114085-113204996)
    African clawed frog
    (Xenopus laevis)
    Amphibia elrD2 RNA-binding protein HuD 85.03(n)    U17599.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131453.12   -- 83.07(n)   30737  NM_131453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fne3
    Rbp91
    RNA binding3
    RNA-binding protein 91
    57(a)
    (best of 5)3
    62.2(n)1
    65.01(a)1
      11D43
    334981  NM_001273045.11  NP_001259974.11 
    worm
    (Caenorhabditis elegans)
    Secernentea exc-71 , 3 HUD3
    exc-71
    65(a)3
    54.05(n)1
    57.73(a)1
      II(9576218-9580987)3
    1745061  NM_063656.41  NP_496057.11 


    ENSEMBL Gene Tree for ELAVL4 (if available)
    TreeFam Gene Tree for ELAVL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELAVL4 gene
    PABPC1L2  PABPC52  PABPC42  ELAVL12  PABPC4L2  RBMS12  ELAVL32  RBMS32  
    PABPC32  ELAVL22  RBMS22  PABPC12  
    7 SIMAP similar genes for ELAVL4 using alignment to 3 protein entries:     ELAV4_HUMAN (see all proteins):
    ELAVL2    ELAVL3    ELAVL1    PABPC4    TIAL1    HNRNPA1
    RBM4B

    Find genes that share paralogs with ELAVL4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELAVL4 (see all 2465)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857506561,2
    --50511716(+) CTGTTC/TTTAGG 1 -- us2k10--------
    rs1152022211,2
    C,F--50511727(+) CTTTAG/AAAGGA 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1908997801,2
    --50512284(+) ATAATA/GTTGAT 1 -- us2k10--------
    rs1819497861,2
    --50512307(+) TTTCAA/TAGAAT 1 -- us2k10--------
    rs1446584221,2
    --50512405(+) CAATGC/GATTTG 1 -- us2k10--------
    rs1478755711,2
    --50512558(+) GAATTA/GCATGA 1 -- us2k10--------
    rs1862527811,2
    --50512657(+) TGTCAC/TCCCAA 1 -- us2k10--------
    rs1414941651,2
    --50512700(+) TATTTA/GGGCCT 1 -- us2k10--------
    rs1907701911,2
    --50512813(+) ATAATC/TTTTCC 1 -- us2k10--------
    rs1500120131,2
    --50512850(+) GGTCTC/TCCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ELAVL4 (50513686 - 50669458 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ELAVL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665070CNV Deletion23128226
    nsv498670CNV Loss21111241
    nsv810CNV Loss18451855
    nsv829826CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELAVL4
    DNA2.0 Custom Variant and Variant Library Synthesis for ELAVL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 168360    OMIM disorders: --

    3 diseases for ELAVL4:    
    About MalaCards
    neuropathy, paraneoplastic sensory    encephalomyelitis    paraneoplastic neurologic disorders


    Find genes that share disorders with ELAVL4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ELAVL4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraneoplastic encephalomyelitis 95.7 17 7541976 (3), 8222755 (2), 1655278 (2), 9288629 (2) (see all 10)
    sensory neuropathy 74.5 3 8069866 (1), 9288629 (1)
    small cell lung cancer 68.9 10 11090964 (2), 9288629 (2), 14512168 (1), 8069866 (1) (see all 7)
    cancer lung 52.1 14 8069866 (6), 7541976 (2), 9288629 (2), 10385591 (1) (see all 5)
    paraneoplastic syndromes 49.2 1 8069866 (1)
    lung carcinoma 38.3 4 9291425 (2), 8619556 (1)
    medulloblastoma 26.4 2 9988134 (2)
    sjogrens syndrome 23.4 1 11283468 (1)
    neurological disorders 21.6 1 9829748 (1)
    tumors 13.8 23 9829748 (5), 9815574 (3), 11090964 (2), 8982120 (1) (see all 12)

    Genetic Association Database (GAD): ELAVL4
    Human Genome Epidemiology (HuGE) Navigator: ELAVL4 (4 documents)

    Export disorders for ELAVL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELAVL4 gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with ELAVL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CARM1 regulates proliferation of PC12 cells by methylating HuD. (PubMed id 16508003)1, 2, 9 Fujiwara T.... Tohyama M. (Mol. Cell. Biol. 2006)
    2. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. (PubMed id 1655278)1, 2, 9 Szabo A.... Furneaux H.M. (Cell 1991)
    3. Molecular analysis of the HuD gene in neuroendocrine lung cancers. (PubMed id 19410329)1, 4, 9 D'Alessandro V....Vendemiale G. (Lung Cancer 2010)
    4. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'- untranslated regions using a novel ELISA-based assay. (PubMed id 10710437)1, 2, 9 King P.H. (Nucleic Acids Res. 2000)
    5. Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. (PubMed id 8222755)1, 3, 9 Muresu R....Siniscalco M. (Cytogenet. Cell Genet. 1994)
    6. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PubMed id 12209604)1, 2, 9 Behrends U.... Mautner J.M. (Int. J. Cancer 2002)
    7. Structural basis for recognition of AU-rich element RNA by the HuD protein. (PubMed id 11175903)1, 2, 9 Wang X. and Tanaka Hall T.M. (Nat. Struct. Biol. 2001)
    8. Replication of association between ELAVL4 and Parkinson disease: the GenePD study. (PubMed id 18587682)1, 4 DeStefano A.L....Myers R.H. (Hum. Genet. 2008)
    9. ELAVL4, PARK10, and the Celts. (PubMed id 17230446)1, 4 Haugarvoll K....Farrer M.J. (Mov. Disord. 2007)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1996 HGNC: 3315 AceView: ELAVL4 Ensembl:ENSG00000162374 euGenes: HUgn1996
    ECgene: ELAVL4 H-InvDB: ELAVL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELAVL4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELAVL4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELAVL4 gene:
    Search GeneIP for patents involving ELAVL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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