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GIFtS

ELAVL4 Gene

protein-coding   GIFtS: 61
GCID: GC01P050513

ELAV (embryonic lethal, abnormal vision, Drosophila)-like...

(Previous names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like...)
(Previous symbol: HUD)
 Explore 28 diseases affiliated with
ELAVL4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ELAVL4    

Aliases
for ELAVL4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 41 2     Paraneoplastic Encephalomyelitis Antigen HuD2 3
HUD1 2 3 5     ELAV-Like Protein 42
PNEM1 2 3 5     Embryonic Lethal, Abnormal Vision, Drosophila, Homolog Of, Like-42
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D)1 2     Hu Antigen D2
Hu-Antigen D2 3     HuD3

External Ids:    HGNC: 33151   Entrez Gene: 19962   Ensembl: ENSG000001623747   OMIM: 1683605   UniProtKB: P263783   

Export aliases for ELAVL4 gene to outside databases

Previous GC identifers: GC01P050199 GC01P049460 GC01P049928 GC01P049941 GC01P050283 GC01P050347 GC01P048632


Summaries
for ELAVL4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
Function: May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR
(By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA

Gene Wiki entry for ELAVL4 (HuD)


Genomic Views
for ELAVL4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ELAVL4 gene promoter:
         E2F-3a   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ELAVL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ELAVL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELAVL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34

ELAVL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELAVL4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P050513:  view genomic region     (about GC identifiers)

Start:
 50,513,686 bp from pter      End:
 50,669,458 bp from pter
Size:
 155,773 bases      Orientation:
 plus strand

Proteins
for ELAVL4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378 (See protein sequence)
Recommended Name: ELAV-like protein 4  
Size: 380 amino acids; 41770 Da
Subunit: Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity)
2 PDB 3D structures from and Proteopedia for ELAVL4:
1FXL (3D)        1G2E (3D)    
Secondary accessions: B1APY6 B1APY7 B7Z4G7 Q8IYD4 Q96J74 Q96J75 Q9UD24
Alternative splicing: 5 isoforms:  P26378-1   P26378-2   P26378-3   P26378-4   P26378-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ELAVL4: NX_P26378

Post-translational modifications:

  • Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A
    • protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which
    facilitates neurite outgrowth (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P26378

    • ELAVL4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138246.1  NP_001138247.1  NP_001138248.1  NP_001138249.1  NP_068771.2  

    ENSEMBL proteins: 
     ENSP00000360892   ENSP00000349594   ENSP00000360889   ENSP00000360888   ENSP00000360886  
     ENSP00000360884   ENSP00000399939  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): ELAVL4
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    Novus Biologicals ELAVL4 Protein
    Novus Biologicals ELAVL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ELAVL4


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    ThermoFisher Antibodies for ELAVL4

    Assay Products for ELAVL4: 
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    Uscn ELISAs and CLIAs for ELAVL4

    Protein Domains /
    Families
    for ELAVL4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ELAVL4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000504 RRM_dom
     IPR006548 ELAD_HUD_SF
     IPR002343 Hud_Sxl_RNA
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P26378

    ProtoNet protein and cluster: P26378

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002343 Paraneoplastic encephalomyelitis antigen family signature


    UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
    Similarity: Belongs to the RRM elav family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Function
    for ELAVL4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
    Function: May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR
    (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA

         Genatlas biochemistry entry for ELAVL4:
    Drosophila Elav-like 4 (embryonic,lethal,abnormal vision),neural specific,expressed in brain,identified using sera from
    patients with a paraplastic multifocal neurologic disorder,homologous to HD,shuttling the ERG class of mRNA to the
    cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded

    miRNA
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    hsa-mir-375 (MIRT005543)

    OriGene 3'-UTR Clone (see all 5): ELAVL4
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELAVL4
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate ELAVL4 (see all 45):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-4307 hsa-miR-429 hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmid: ELAVL4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELAVL4 (see all 7)
    OriGene shRNA RFP: ELAVL4
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELAVL4

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELAVL4 (see all 11)
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for ELAVL4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELAVL4

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding TAS1655278
    GO:0003730mRNA 3'-UTR binding TAS10848602
    GO:0017091AU-rich element binding IDA10710437


    ELAVL4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ELAVL4:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Elavl4tm1Okn for ELAVL4
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Elavl4):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging  nervous system 
     reproductive system 

    ELAVL4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ELAVL4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ELAVL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for ELAVL4 (P263782, 3 ENSP000003495944) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU93, ENSP000002941724I2D: score=1 STRING: ENSP00000294172
    ELAVL2Q129263, ENSP000003694604I2D: score=1 STRING: ENSP00000369460
    NFX1Q129863, ENSP000003688564I2D: score=1 STRING: ENSP00000368856
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    IGF2BP1Q9NZI83I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing TAS1655278
    GO:0006397mRNA processing TAS10348344


    ELAVL4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ELAVL4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ELAVL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ELAVL4
    2 Novoseek chemical compound relationships for ELAVL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly u 56.2 2 12900401 (1), 17234598 (1)
    adenylate 0.441 4 12034726 (3), 17234598 (1)

    Search CenterWatch for drugs/clinical trials and news about ELAVL4 / ELAV4 

    Transcripts
    for ELAVL4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ELAVL4 gene (5 alternative transcripts): 
    NM_001144774.1  NM_001144775.1  NM_001144776.1  NM_001144777.1  NM_021952.3  

    Unigene Cluster for ELAVL4:

    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4
    Hs.213050  [show with all ESTs]
    Unigene Representative Sequence: BC036071
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371827(uc001crz.3) ENST00000463650 ENST00000357083 ENST00000371824(uc001csb.2 uc001csc.3)
    ENST00000371823 ENST00000371821 ENST00000371819(uc009vyu.3 uc010omz.2)
    ENST00000494555 ENST00000492299 ENST00000474675 ENST00000448907(uc001cry.3 uc001csa.3)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELAVL4
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate ELAVL4 (see all 45):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-4307 hsa-miR-429 hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmid: ELAVL4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELAVL4 (see all 7)
    OriGene shRNA RFP: ELAVL4
    OriGene siRNA: ELAVL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELAVL4
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): ELAVL4 (NM_001144774)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELAVL4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELAVL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELAVL4

    Additional cDNA sequence: 

    AK297338.1 AK298817.1 AK298902.1 AK309653.1 AY033995.1 AY033996.1 AY033997.1 AY033998.1 
    BC036071.1 BX648050.1 M62843.1 S73887.1 

    10 DOTS entries:

    DT.312181  DT.410852  DT.92417808  DT.95371093  DT.40212820  DT.455326  DT.101966995  DT.121377620 
    DT.121377635  DT.91897490 

    24/83 AceView cDNA sequences (see all 83):

    CR625475 AW088230 AY033996 BQ720948 T16673 AY033997 AA975446 AW665788 
    BM693606 AU100542 BM711406 BM669192 CR595508 CR613627 BX106243 T28890 
    AW341000 AA211071 CA772196 AV725356 AY033995 BQ185858 M85762 AY033998 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL4 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:              -     -     -     -     -                       -                                   -         
    SP2:                    -     -     -     -                       -                                             
    SP3:                    -     -     -     -                       -                                   -         
    SP4:        -     -     -     -     -     -                       -                                   -         
    SP5:                                      -                       -                                             


    ECgene alternative splicing isoforms for ELAVL4

    Expression
    for ELAVL4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ELAVL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACTTTATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ELAVL4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    OvaryOvigerous CordOvarian Somatic CellsOvary
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ELAVL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ELAVL4

    SOURCE GeneReport for Unigene cluster: Hs.213050

    UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
    Tissue specificity: Brain

        SABiosciences Custom PCR Arrays for ELAVL4
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    In Situ
    Assay Products:     
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    Orthologs
    for ELAVL4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ELAVL4 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ELAVL41 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 88(n)
    98.35(a)    		   395634  NM_204830.1  NP_990161.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ELAVL46
    		 --
    		 96(a)
    		 1 ↔ 1
    		 4(113142383-113202082)
    African clawed frog
    (Xenopus laevis)    		 Amphibia elrD2 RNA-binding protein HuD 85.03(n)    U17599.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii NM_131453.12   -- 83.07(n)   30737  NM_131453.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fne3
    Rbp91    		 RNA binding3
    RNA-binding protein 91    		 57(a)
    (best of 5)3
    60.29(n)1
    62.86(a)1    		   11D43
    334981  NM_001014462.21  NP_001014462.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea exc-73 HUD 65(a)   II(9576218-9580987)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G473106
    FCA6
    		 RNA binding / abscisic acid binding protein
    		 12(a)
    10(a)
    		 many ↔ many
    many ↔ many
    		 2(19423684-19427277)
    4(9206597-9214825)
    rice
    (Oryza sativa)    		 Liliopsida FCA6
    		 flowering time control protein FCA, putative, expr...
    		 9(a)
    		 1 → many
    		 9(1789446-1798611)


    ENSEMBL Gene Tree for ELAVL4 (if available)
    TreeFam Gene Tree for ELAVL4 (if available) 

    Paralogs
    for ELAVL4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ELAVL4 gene
    PABPC1L2  PABPC52  PABPC42  PABPC4L2  ELAVL12  RBMS12  RBMS32  ELAVL32  
    PABPC32  PABPC1L2B2  ELAVL22  PABPC1L2A2  PUF602  RBMS22  PABPC12  
    7 SIMAP similar genes for ELAVL4 using alignment to 3 protein entries:     ELAV4_HUMAN (see all proteins):
    ELAVL2    ELAVL3    ELAVL1    PABPC4    TIAL1    HNRNPA1
    RBM4B

    ELAVL4 for paralogs           About GeneDecksing



    Genomic Variants
    for ELAVL4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2036 NCBI SNPs in ELAVL4 are shown (see all 2036)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1857506561,2
    		--50511716(+) CTGTTC/TTTAGG 1 -- us2k10--------
    rs1152022211,2
    		F,--50511727(+) CTTTAG/AAAGGA 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1908997801,2
    		--50512284(+) ATAATA/GTTGAT 1 -- us2k10--------
    rs1819497861,2
    		--50512307(+) TTTCAA/TAGAAT 1 -- us2k10--------
    rs1446584221,2
    		--50512405(+) CAATGC/GATTTG 1 -- us2k10--------
    rs1478755711,2
    		--50512558(+) GAATTA/GCATGA 1 -- us2k10--------
    rs1862527811,2
    		--50512657(+) TGTCAC/TCCCAA 1 -- us2k10--------
    rs1414941651,2
    		--50512700(+) TATTTA/GGGCCT 1 -- us2k10--------
    rs1907701911,2
    		--50512813(+) ATAATC/TTTTCC 1 -- us2k10--------
    rs1500120131,2
    		--50512850(+) GGTCTC/TCCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ELAVL4 (50513686 - 50669458 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ELAVL4
         1 CNV: 34825

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ELAVL4

    Disorders / Diseases
    for ELAVL4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ELAVL4 for disorders           About GeneDecksing

    OMIM gene information: 168360    OMIM disorders: --

    20/28 diseases for ELAVL4 (see all 28):    About MalaCards
    lambert-eaton myasthenic syndrome    encephalomyelitis    neuropathy, paraneoplastic sensory    age related macular degeneration
    sensory peripheral neuropathy    paraneoplastic neurologic disorders    myasthenic syndrome    peripheral neuropathy
    macular degeneration    paraneoplastic syndromes    neuropathy    sjogren's syndrome
    motor neuron disease    cerebellar ataxia    neurologic diseases    lung carcinoma
    lung cancer    parkinson's disease    ataxia    t-cell leukemia

    10/12 Novoseek disease relationships for ELAVL4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraneoplastic encephalomyelitis 95.7 17 7541976 (3), 8222755 (2), 1655278 (2), 9288629 (2) (see all 10)
    sensory neuropathy 74.5 3 8069866 (1), 9288629 (1)
    small cell lung cancer 68.9 10 11090964 (2), 9288629 (2), 14512168 (1), 8069866 (1) (see all 7)
    cancer lung 52.1 14 8069866 (6), 7541976 (2), 9288629 (2), 10385591 (1) (see all 5)
    paraneoplastic syndromes 49.2 1 8069866 (1)
    lung carcinoma 38.3 4 9291425 (2), 8619556 (1)
    medulloblastoma 26.4 2 9988134 (2)
    sjogrens syndrome 23.4 1 11283468 (1)
    neurological disorders 21.6 1 9829748 (1)
    tumors 13.8 23 9829748 (5), 9815574 (3), 11090964 (2), 8982120 (1) (see all 12)

    Genetic Association Database (GAD): ELAVL4
    Human Genome Epidemiology (HuGE) Navigator: ELAVL4 (4 documents)

    Export disorders for ELAVL4 gene to outside databases

    Publications
    for ELAVL4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ELAVL4 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with ELAVL4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CARM1 regulates proliferation of PC12 cells by methylating HuD. (PubMed id 16508003)1, 2, 9 Fujiwara T.... Tohyama M. (2006)
    2. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. (PubMed id 1655278)1, 2, 9 Szabo A.... Furneaux H.M. (1991)
    3. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'- untranslated regions using a novel ELISA-based assay. (PubMed id 10710437)1, 2, 9 King P.H. (2000)
    4. Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. (PubMed id 8222755)1, 3, 9 Muresu R....Siniscalco M. (1994)
    5. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PubMed id 12209604)1, 2, 9 Behrends U.... Mautner J.M. (2002)
    6. Structural basis for recognition of AU-rich element RNA by the HuD protein. (PubMed id 11175903)1, 2, 9 Wang X. and Tanaka Hall T.M. (2001)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Evaluation of the ELOVL4 gene in patients with age-related macular degeneration. (PubMed id 11803489)1, 4 Ayyagari R....Allikmets R. (2001)
    9. Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines. (PubMed id 8069866)1, 9 Sekido Y.... Minna J.D. (1994)
    10. Loss of one HuD allele on chromosome #1p selects for amplification of the N-myc proto-oncogene in human neuroblastoma cells. (PubMed id 16278682)1, 9 Grandinetti K.B....Ross R.A. (2006)

    External Searches for ELAVL4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing ELAVL4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1996 HGNC: 3315 AceView: ELAVL4 Ensembl:ENSG00000162374 euGenes: HUgn1996
    ECgene: ELAVL4 H-InvDB: ELAVL4

    Other Databases showing ELAVL4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ELAVL4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ELAVL4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELAVL4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ELAVL4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ELAVL4 gene:
    Search GeneIP for patents involving ELAVL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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