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Aliases for ELAVL4 Gene

Aliases for ELAVL4 Gene

  • ELAV Like RNA Binding Protein 4 2 3 5
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D) 2 3
  • ELAV Like Neuron-Specific RNA Binding Protein 4 2 3
  • Paraneoplastic Encephalomyelitis Antigen HuD 3 4
  • Hu Antigen D 2 3
  • PNEM 3 4
  • HUD 3 4
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 2
  • ELAV-Like Protein 4 3
  • Hu-Antigen D 4

External Ids for ELAVL4 Gene

Previous HGNC Symbols for ELAVL4 Gene

  • HUD

Previous GeneCards Identifiers for ELAVL4 Gene

  • GC01P050199
  • GC01P049460
  • GC01P049928
  • GC01P049941
  • GC01P050283
  • GC01P050347
  • GC01P050513
  • GC01P048632

Summaries for ELAVL4 Gene

GeneCards Summary for ELAVL4 Gene

ELAVL4 (ELAV Like RNA Binding Protein 4) is a Protein Coding gene. Diseases associated with ELAVL4 include Hallucinogen Abuse and Paraneoplastic Neurologic Disorders. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ELAVL2.

UniProtKB/Swiss-Prot for ELAVL4 Gene

  • May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.

Gene Wiki entry for ELAVL4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL4 Gene

Genomics for ELAVL4 Gene

Regulatory Elements for ELAVL4 Gene

Enhancers for ELAVL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G050332 1.2 Ensembl ENCODE 9.8 +285.4 285369 1.3 ATF1 AGO1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 ZNF263 REST ZNF610 RPS2P11 ENSG00000237337 ELAVL4 GC01M050274
GH01G050109 1 Ensembl ENCODE dbSUPER 10.7 +62.2 62187 1.6 MXI1 POLR2A SMARCA4 EZH2 ELAVL4 ENSG00000237337 ENSG00000230828 GC01P050110
GH01G050115 0.5 dbSUPER 10.6 +69.2 69239 3.1 CTCF POLR2A SMARCA4 SCRT2 ELAVL4 LOC105378711 ENSG00000237337 ENSG00000230828 GC01M050123
GH01G050271 0.5 ENCODE 10.4 +223.5 223450 0.2 POLR2A SMARCA4 REST RAD21 ENSG00000237337 ELAVL4 GC01P050269 LOC105378712
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELAVL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELAVL4 Gene

50,048,014 bp from pter
50,203,786 bp from pter
155,773 bases
Plus strand

Genomic View for ELAVL4 Gene

Genes around ELAVL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL4 Gene

Proteins for ELAVL4 Gene

  • Protein details for ELAVL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ELAV-like protein 4
    Protein Accession:
    Secondary Accessions:
    • B1APY6
    • B1APY7
    • B7Z4G7
    • Q8IYD4
    • Q96J74
    • Q96J75
    • Q9UD24

    Protein attributes for ELAVL4 Gene

    380 amino acids
    Molecular mass:
    41770 Da
    Quaternary structure:
    • Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP.

    Three dimensional structures from OCA and Proteopedia for ELAVL4 Gene

    Alternative splice isoforms for ELAVL4 Gene


neXtProt entry for ELAVL4 Gene

Post-translational modifications for ELAVL4 Gene

  • Methylation at Arg-243 by CARM1 weakens protective binding to the 3-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ELAVL4 Gene

Domains & Families for ELAVL4 Gene

Gene Families for ELAVL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRM elav family.
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL4: view

Function for ELAVL4 Gene

Molecular function for ELAVL4 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 4 (embryonic,lethal,abnormal vision),neural specific,expressed in brain,identified using sera from patients with a paraplastic multifocal neurologic disorder,homologous to HD,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded
UniProtKB/Swiss-Prot Function:
May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.

Gene Ontology (GO) - Molecular Function for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS 1655278
GO:0003729 mRNA binding IEA --
GO:0003730 mRNA 3-UTR binding TAS 10848602
GO:0017091 AU-rich element binding IDA 10710437
genes like me logo Genes that share ontologies with ELAVL4: view
genes like me logo Genes that share phenotypes with ELAVL4: view

Animal Models for ELAVL4 Gene

MGI Knock Outs for ELAVL4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL4 Gene

Localization for ELAVL4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELAVL4 gene
Compartment Confidence
nucleus 4
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ELAVL4 Gene

Pathways & Interactions for ELAVL4 Gene

SuperPathways for ELAVL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 1655278
GO:0006397 mRNA processing TAS 10348344
GO:0007612 learning IEA --
GO:0007626 locomotory behavior IEA --
GO:0048813 dendrite morphogenesis IEA --
genes like me logo Genes that share ontologies with ELAVL4: view

No data available for Pathways by source and SIGNOR curated interactions for ELAVL4 Gene

Drugs & Compounds for ELAVL4 Gene

(2) Additional Compounds for ELAVL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELAVL4: view

Transcripts for ELAVL4 Gene

Unigene Clusters for ELAVL4 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: -
SP7: - -
SP9: - - -

Relevant External Links for ELAVL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ELAVL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELAVL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x11.3), Brain - Anterior cingulate cortex (BA24) (x8.6), Brain - Cortex (x6.5), Brain - Hypothalamus (x5.2), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for ELAVL4 Gene

This gene is overexpressed in Brain (39.1) and Fetal Brain (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ELAVL4 Gene

Protein tissue co-expression partners for ELAVL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELAVL4 Gene:


SOURCE GeneReport for Unigene cluster for ELAVL4 Gene:


mRNA Expression by UniProt/SwissProt for ELAVL4 Gene:

Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for ELAVL4 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ELAVL4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ELAVL4 Gene

Orthologs for ELAVL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ELAVL4 34 35
  • 99.36 (n)
(Monodelphis domestica)
Mammalia ELAVL4 35
  • 97 (a)
(Bos Taurus)
Mammalia ELAVL4 34 35
  • 96.36 (n)
(Ornithorhynchus anatinus)
Mammalia ELAVL4 35
  • 96 (a)
(Canis familiaris)
Mammalia ELAVL4 34 35
  • 95.35 (n)
(Rattus norvegicus)
Mammalia Elavl4 34
  • 94.91 (n)
(Mus musculus)
Mammalia Elavl4 34 16 35
  • 94.08 (n)
(Gallus gallus)
Aves ELAVL4 35 34
  • 87.7 (n)
(Anolis carolinensis)
Reptilia ELAVL4 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl4 34
  • 84.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia elrD 34
(Danio rerio)
Actinopterygii elavl4 34 35
  • 82.23 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Rbp9 34 35
  • 62.2 (n)
fne 36 35
  • 57 (a)
elav 36 35
  • 52 (a)
Sxl 36
  • 46 (a)
EG:132E8.1 36
  • 43 (a)
CG5213 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea exc-7 36 34 35
  • 54.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 35
  • 55 (a)
Species where no ortholog for ELAVL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL4 Gene

Gene Tree for ELAVL4 (if available)
Gene Tree for ELAVL4 (if available)

Paralogs for ELAVL4 Gene

(7) SIMAP similar genes for ELAVL4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ELAVL4: view

Variants for ELAVL4 Gene

Sequence variations from dbSNP and Humsavar for ELAVL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000016218 -- 50,159,631(+) TGGGG(C/G)GCTCT intron-variant
rs1000036171 -- 50,201,742(+) AACTT(C/T)TGCAA utr-variant-3-prime
rs1000040766 -- 50,066,645(+) GAAGA(G/T)AAAAA intron-variant
rs1000045948 -- 50,160,572(+) TTTCT(G/T)CATTT intron-variant
rs1000054716 -- 50,194,161(+) AGGGT(G/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL4 Gene

Variant ID Type Subtype PubMed ID
esv2665070 CNV deletion 23128226
esv3586005 CNV loss 21293372
nsv1003968 CNV gain 25217958
nsv1110659 CNV insertion 24896259
nsv498670 CNV loss 21111241
nsv810 CNV deletion 18451855
nsv829826 CNV gain 17160897

Variation tolerance for ELAVL4 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELAVL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL4 Gene

Disorders for ELAVL4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ELAVL4 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ELAVL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ELAVL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL4 Gene

Publications for ELAVL4 Gene

  1. Molecular analysis of the HuD gene in neuroendocrine lung cancers. (PMID: 19410329) D'Alessandro V. … Vendemiale G. (Lung Cancer 2010) 3 22 46 64
  2. CARM1 regulates proliferation of PC12 cells by methylating HuD. (PMID: 16508003) Fujiwara T. … Tohyama M. (Mol. Cell. Biol. 2006) 3 4 22 64
  3. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PMID: 12209604) Behrends U. … Mautner J.M. (Int. J. Cancer 2002) 3 4 22 64
  4. Structural basis for recognition of AU-rich element RNA by the HuD protein. (PMID: 11175903) Wang X. … Tanaka Hall T.M. (Nat. Struct. Biol. 2001) 3 4 22 64
  5. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'- untranslated regions using a novel ELISA-based assay. (PMID: 10710437) King P.H. (Nucleic Acids Res. 2000) 3 4 22 64

Products for ELAVL4 Gene

Sources for ELAVL4 Gene

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