Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ELAVL4 Gene

protein-coding   GIFtS: 61
GCID: GC01P050513

ELAV Like Neuron-Specific RNA Binding Protein 4

(Previous names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like...)
(Previous symbol: HUD)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ELAV Like Neuron-Specific RNA Binding Protein 41     Hu-Antigen D2 3
HUD1 2 3 5     Paraneoplastic Encephalomyelitis Antigen HuD2 3
PNEM2 3 5     ELAV-Like Protein 42
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 41 2     Embryonic Lethal, Abnormal Vision, Drosophila, Homolog Of, Like-42
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D)1 2     HuD3
Hu Antigen D1 2     

External Ids:    HGNC: 33151   Entrez Gene: 19962   Ensembl: ENSG000001623747   OMIM: 1683605   UniProtKB: P263783   

Export aliases for ELAVL4 gene to outside databases

Previous GC identifers: GC01P050199 GC01P049460 GC01P049928 GC01P049941 GC01P050283 GC01P050347 GC01P048632


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ELAVL4 Gene: 
ELAVL4 (ELAV like neuron-specific RNA binding protein 4) is a protein-coding gene. Diseases associated with ELAVL4 include encephalomyelitis, and sensory peripheral neuropathy. GO annotations related to this gene include mRNA 3'-UTR binding and RNA binding. An important paralog of this gene is PABPC1L.

UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
Function: May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its
3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA

Gene Wiki entry for ELAVL4 (HuD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ELAVL4 gene promoter:
         E2F-3a   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELAVL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ELAVL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELAVL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34

ELAVL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELAVL4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P050513:  view genomic region     (about GC identifiers)

Start:
50,513,686 bp from pter      End:
50,669,458 bp from pter
Size:
155,773 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378 (See protein sequence)
Recommended Name: ELAV-like protein 4  
Size: 380 amino acids; 41770 Da
Subunit: Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity)
2 PDB 3D structures from and Proteopedia for ELAVL4:
1FXL (3D)        1G2E (3D)    
Secondary accessions: B1APY6 B1APY7 B7Z4G7 Q8IYD4 Q96J74 Q96J75 Q9UD24
Alternative splicing: 5 isoforms:  P26378-1   P26378-2   P26378-3   P26378-4   P26378-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ELAVL4: NX_P26378

Explore proteomics data for ELAVL4 at MOPED 

Post-translational modifications:

  • UniProtKB: Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A
    protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which
    facilitates neurite outgrowth (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26378

  • ELAVL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ELAVL4 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001138246.1  NP_001138247.1  NP_001138248.1  NP_001138249.1  NP_068771.2  

    ENSEMBL proteins: 
     ENSP00000360892   ENSP00000349594   ENSP00000360889   ENSP00000360888   ENSP00000360886  
     ENSP00000360884   ENSP00000399939  

    Human Recombinant Protein Products for ELAVL4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ELAVL4
    OriGene Protein Over-expression Lysate for ELAVL4
    OriGene MassSpec for ELAVL4 
    OriGene Custom Protein Services for ELAVL4
    GenScript Custom Purified and Recombinant Proteins Services for ELAVL4
    Novus Biologicals ELAVL4 Protein
    Novus Biologicals ELAVL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ELAVL4 


    ELAVL4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ELAVL4
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ELAVL4
    GenScript Custom Superior Antibodies Services for ELAVL4
    Novus Biologicals ELAVL4 Antibodies
    Abcam antibodies for ELAVL4
    Cloud-Clone Corp. Antibodies for ELAVL4 
    ThermoFisher Antibodies for ELAVL4
    LSBio Antibodies in human, mouse, rat for ELAVL4 

    Assay Products for ELAVL4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ELAVL4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELAVL4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ELAVL4 
    Cloud-Clone Corp. CLIAs for ELAVL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR000504 RRM_dom
     IPR006548 ELAD_HUD_SF
     IPR002343 Hud_Sxl_RNA
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P26378

    ProtoNet protein and cluster: P26378

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002343 Paraneoplastic encephalomyelitis antigen family signature


    UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
    Similarity: Belongs to the RRM elav family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    ELAVL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELAV4_HUMAN, P26378
    Function: May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its
    3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA

         Genatlas biochemistry entry for ELAVL4:
    Drosophila Elav-like 4 (embryonic,lethal,abnormal vision),neural specific,expressed in brain,identified using sera
    from patients with a paraplastic multifocal neurologic disorder,homologous to HD,shuttling the ERG class of mRNA
    to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS1655278
    GO:0003730mRNA 3'-UTR binding TAS10848602
    GO:0017091AU-rich element binding IDA10710437
         
    ELAVL4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ELAVL4:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Elavl4):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging  nervous system 
     reproductive system 

    ELAVL4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Elavl4tm1Okn for ELAVL4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ELAVL4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ELAVL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELAVL4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELAVL4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ELAVL4:
    hsa-mir-375 (MIRT005543)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELAVL4
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate ELAVL4 (see all 45):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-4307 hsa-miR-429 hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidELAVL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ELAVL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELAVL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ELAVL4
    Sirion Biotech Customized adenovirus for overexpression of ELAVL4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ELAVL4 (see all 29)
    OriGene ORF clones in mouse, rat for ELAVL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ELAVL4 (NM_001144774)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELAVL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELAVL4
    Sirion Biotech Customized lentivirus for stable overexpression of ELAVL4 
                         Customized lentivirus expression plasmids for stable overexpression of ELAVL4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ELAVL4
    Search LifeMap BioReagents cell lines for ELAVL4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELAVL4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ELAVL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for ELAVL4 (P263782, 3 ENSP000003495944) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU93, ENSP000002941724I2D: score=1 STRING: ENSP00000294172
    ELAVL2Q129263, ENSP000003694604I2D: score=1 STRING: ENSP00000369460
    NFX1Q129863, ENSP000003688564I2D: score=1 STRING: ENSP00000368856
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    IGF2BP1Q9NZI83I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing TAS1655278
    GO:0006397mRNA processing TAS10348344

    ELAVL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ELAVL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ELAVL4 (ELAV4)

    2 Novoseek inferred chemical compound relationships for ELAVL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly u 56.2 2 12900401 (1), 17234598 (1)
    adenylate 0.441 4 12034726 (3), 17234598 (1)

    Search CenterWatch for drugs/clinical trials and news about ELAVL4 / ELAV4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ELAVL4 gene (5 alternative transcripts): 
    NM_001144774.1  NM_001144775.1  NM_001144776.1  NM_001144777.1  NM_021952.3  

    Unigene Cluster for ELAVL4:

    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4
    Hs.213050  [show with all ESTs]
    Unigene Representative Sequence: BC036071
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371827(uc001crz.3) ENST00000463650 ENST00000357083 ENST00000371824(uc001csb.2 uc001csc.3)
    ENST00000371823 ENST00000371821 ENST00000371819(uc009vyu.3 uc010omz.2)
    ENST00000494555 ENST00000492299 ENST00000474675 ENST00000448907(uc001cry.3 uc001csa.3)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELAVL4
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate ELAVL4 (see all 45):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-4307 hsa-miR-429 hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidELAVL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ELAVL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELAVL4
    Clone
    Products:
         
    OriGene clones in human, mouse for ELAVL4 (see all 29)
    OriGene ORF clones in mouse, rat for ELAVL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ELAVL4 (NM_001144774)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELAVL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELAVL4
    Sirion Biotech Customized lentivirus for stable overexpression of ELAVL4 
                         Customized lentivirus expression plasmids for stable overexpression of ELAVL4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ELAVL4
    OriGene qSTAR qPCR primer pairs in human, mouse for ELAVL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELAVL4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELAVL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELAVL4

    Additional mRNA sequence: 

    AK297338.1 AK298817.1 AK298902.1 AK309653.1 AY033995.1 AY033996.1 AY033997.1 AY033998.1 
    BC036071.1 BX648050.1 M62843.1 S73887.1 

    10 DOTS entries:

    DT.312181  DT.410852  DT.92417808  DT.95371093  DT.40212820  DT.455326  DT.101966995  DT.121377620 
    DT.121377635  DT.91897490 

    24/83 AceView cDNA sequences (see all 83):

    BM711406 BX106243 BM693606 AV725356 T28890 AW341000 AY033995 AW088230 
    AU100542 AA975446 BM669192 AY033997 CR625475 AY033996 CA772196 BQ720948 
    T16673 AA211071 CR595508 AW665788 CR613627 BQ267762 AI291675 R45008 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL4 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:              -     -     -     -     -                       -                                   -         
    SP2:                    -     -     -     -                       -                                             
    SP3:                    -     -     -     -                       -                                   -         
    SP4:        -     -     -     -     -     -                       -                                   -         
    SP5:                                      -                       -                                             


    ECgene alternative splicing isoforms for ELAVL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ELAVL4 expression in normal human tissues (normalized intensities)      ELAVL4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTTATAA
    ELAVL4 Expression
    About this image


    ELAVL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 31 entries
             Endothelial Cells Blood Brain Barrier
             Thalamus
             Globus Pallidus   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Postnatal Endothelial Cells Blood Brain Barrier

    See ELAVL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ELAVL4

    SOURCE GeneReport for Unigene cluster: Hs.213050

    UniProtKB/Swiss-Prot: ELAV4_HUMAN, P26378
    Tissue specificity: Brain

        SABiosciences Custom PCR Arrays for ELAVL4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ELAVL4
    OriGene qSTAR qPCR primer pairs in human, mouse for ELAVL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELAVL4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELAVL4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELAVL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELAVL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ELAVL4 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elavl41 , 5 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more1, 5 94.65(n)1
    99.74(a)1
      4 (51.42 cM)5
    155721  NM_001038698.11  NP_001033787.11 
     1102037225 
    chicken
    (Gallus gallus)
    Aves ELAVL41 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 88(n)
    98.35(a)
      395634  NM_204830.1  NP_990161.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELAVL46
    ELAV (embryonic lethal, abnormal vision, Drosophil...
    94(a)
    1 ↔ 1
    4(113114085-113204996)
    African clawed frog
    (Xenopus laevis)
    Amphibia elrD2 RNA-binding protein HuD 85.03(n)    U17599.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131453.12   -- 83.07(n)   30737  NM_131453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fne3
    Rbp91
    RNA binding3
    RNA-binding protein 91
    57(a)
    (best of 5)3
    60.29(n)1
    62.86(a)1
      11D43
    334981  NM_001014462.21  NP_001014462.11 
    worm
    (Caenorhabditis elegans)
    Secernentea exc-73 HUD 65(a)   II(9576218-9580987)   --


    ENSEMBL Gene Tree for ELAVL4 (if available)
    TreeFam Gene Tree for ELAVL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ELAVL4 gene
    PABPC1L2  PABPC52  PABPC42  ELAVL12  PABPC4L2  RBMS12  ELAVL32  RBMS32  
    PABPC32  PABPC1L2B2  ELAVL22  PABPC1L2A2  RBMS22  PABPC12  
    7 SIMAP similar genes for ELAVL4 using alignment to 3 protein entries:     ELAV4_HUMAN (see all proteins):
    ELAVL2    ELAVL3    ELAVL1    PABPC4    TIAL1    HNRNPA1
    RBM4B

    ELAVL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2465 SNPs in ELAVL4 are shown (see all 2465)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857506561,2
    --50511716(+) CTGTTC/TTTAGG 1 -- us2k10--------
    rs1152022211,2
    C,F--50511727(+) CTTTAG/AAAGGA 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1908997801,2
    --50512284(+) ATAATA/GTTGAT 1 -- us2k10--------
    rs1819497861,2
    --50512307(+) TTTCAA/TAGAAT 1 -- us2k10--------
    rs1446584221,2
    --50512405(+) CAATGC/GATTTG 1 -- us2k10--------
    rs1478755711,2
    --50512558(+) GAATTA/GCATGA 1 -- us2k10--------
    rs1862527811,2
    --50512657(+) TGTCAC/TCCCAA 1 -- us2k10--------
    rs1414941651,2
    --50512700(+) TATTTA/GGGCCT 1 -- us2k10--------
    rs1907701911,2
    --50512813(+) ATAATC/TTTTCC 1 -- us2k10--------
    rs1500120131,2
    --50512850(+) GGTCTC/TCCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ELAVL4 (50513686 - 50669458 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ELAVL4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665070CNV Deletion23128226
    nsv498670CNV Loss21111241
    nsv810CNV Loss18451855
    nsv829826CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ELAVL4
    DNA2.0 Custom Variant and Variant Library Synthesis for ELAVL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 168360    OMIM disorders: --

    20/24 diseases for ELAVL4 (see all 24):    About MalaCards
    encephalomyelitis    sensory peripheral neuropathy    paraneoplastic neurologic disorders    lambert-eaton myasthenic syndrome
    paraneoplastic syndromes    peripheral neuropathy    motor neuron disease    sjogren's syndrome
    neurologic diseases    cerebellar ataxia    neuropathy    age related macular degeneration
    macular degeneration    lung cancer    medulloblastoma    neuroblastoma
    ataxia    t-cell leukemia    parkinson's disease    retinitis


    ELAVL4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for ELAVL4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraneoplastic encephalomyelitis 95.7 17 7541976 (3), 8222755 (2), 1655278 (2), 9288629 (2) (see all 10)
    sensory neuropathy 74.5 3 8069866 (1), 9288629 (1)
    small cell lung cancer 68.9 10 11090964 (2), 9288629 (2), 14512168 (1), 8069866 (1) (see all 7)
    cancer lung 52.1 14 8069866 (6), 7541976 (2), 9288629 (2), 10385591 (1) (see all 5)
    paraneoplastic syndromes 49.2 1 8069866 (1)
    lung carcinoma 38.3 4 9291425 (2), 8619556 (1)
    medulloblastoma 26.4 2 9988134 (2)
    sjogrens syndrome 23.4 1 11283468 (1)
    neurological disorders 21.6 1 9829748 (1)
    tumors 13.8 23 9829748 (5), 9815574 (3), 11090964 (2), 8982120 (1) (see all 12)

    Genetic Association Database (GAD): ELAVL4
    Human Genome Epidemiology (HuGE) Navigator: ELAVL4 (4 documents)

    Export disorders for ELAVL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ELAVL4 gene, integrated from 9 sources (see all 110):
    (articles sorted by number of sources associating them with ELAVL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CARM1 regulates proliferation of PC12 cells by methylating HuD. (PubMed id 16508003)1, 2, 9 Fujiwara T.... Tohyama M. (2006)
    2. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. (PubMed id 1655278)1, 2, 9 Szabo A.... Furneaux H.M. (1991)
    3. Molecular analysis of the HuD gene in neuroendocrine lung cancers. (PubMed id 19410329)1, 4, 9 D'Alessandro V....Vendemiale G. (2009)
    4. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'- untranslated regions using a novel ELISA-based assay. (PubMed id 10710437)1, 2, 9 King P.H. (2000)
    5. Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. (PubMed id 8222755)1, 3, 9 Muresu R....Siniscalco M. (1994)
    6. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PubMed id 12209604)1, 2, 9 Behrends U.... Mautner J.M. (2002)
    7. Structural basis for recognition of AU-rich element RNA by the HuD protein. (PubMed id 11175903)1, 2, 9 Wang X. and Tanaka Hall T.M. (2001)
    8. Replication of association between ELAVL4 and Parkinson disease: the GenePD study. (PubMed id 18587682)1, 4 DeStefano A.L....Myers R.H. (2008)
    9. ELAVL4, PARK10, and the Celts. (PubMed id 17230446)1, 4 Haugarvoll K....Farrer M.J. (2007)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1996 HGNC: 3315 AceView: ELAVL4 Ensembl:ENSG00000162374 euGenes: HUgn1996
    ECgene: ELAVL4 H-InvDB: ELAVL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ELAVL4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELAVL4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ELAVL4 gene:
    Search GeneIP for patents involving ELAVL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ELAVL4
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ELAVL4  
     OriGene qPCR primer pairs and template standards for ELAVL4   OriGene Protein Over-expression Lysate for ELAVL4  
     OriGene MassSpec something-or-other for ELAVL4   OriGene clones in human, mouse for ELAVL4  
     OriGene qSTAR qPCR primer pairs in human, mouse for ELAVL4   OriGene Purified Protein for ELAVL4  
     OriGene ORF clones in mouse, rat for ELAVL4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ELAVL4   OriGene Custom Protein Services for ELAVL4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ELAVL4
     QIAGEN SeqTarget long-range PCR primers for resequencing ELAVL4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELAVL4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELAVL4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELAVL4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELAVL4
     GenScript Custom Purified and Recombinant Proteins Services for ELAVL4 GenScript cDNA clones with any tag delivered in your preferred vector for ELAVL4
     GenScript Custom Assay Services for ELAVL4 GenScript Custom Superior Antibodies Services for ELAVL4
     GenScript Custom overexpressing Cell Line Services for ELAVL4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ELAVL4 promoter
     Search Chromatin IP Primers for ELAVL4
     RT2 qPCR Primer Assay in human, mouse, rat ELAVL4
     GNC Network for ELAVL4
     SABiosciences Custom PCR Arrays for ELAVL4
     Search Tocris compounds for ELAVL4 (ELAV4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ELAVL4 antibodies
     ELAVL4 proteins
     ELAVL4 lysates
     Antibodies for ELAVL4
     See all of Abcam's Antibodies, Kits and Proteins for ELAVL4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ELAVL4
     Antibodies for ELAVL4
     ELISAs for ELAVL4
     CLIAs for ELAVL4
     Search LifeMap BioReagents cell lines for ELAVL4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELAVL4
     SwitchGear 3'UTR luciferase reporter plasmids for ELAVL4
     SwitchGear Promoter luciferase reporter plasmids for ELAVL4
     ThermoFisher Antibodies for ELAVL4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELAVL4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ELAVL4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ELAVL4
    Customized:
     lentivirus for stable overexpression of ELAVL4
     lentivirus expression plasmids for stable overexpression of ELAVL4
     adenovirus for overexpression of ELAVL4
     LSBio Antibodies in human, mouse, rat for ELAVL4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ELAVL4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4