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ELAVL3 Gene

protein-coding   GIFtS: 55
GCID: GC19M011562

ELAV Like Neuron-Specific RNA Binding Protein 3

(Previous names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ELAV Like Neuron-Specific RNA Binding Protein 31 2     ELAV-Like Protein 31 2
Paraneoplastic Cerebellar Degeneration-Associated Antigen1 2 3     Hu Antigen C1 2
Paraneoplastic Limbic Encephalitis Antigen 211 2 3     Hu-Antigen C2 3
HUC2 3 5     HUCL2
PLE212 3 5     HuC3
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 3 (Hu Antigen C)1 2     

External Ids:    HGNC: 33141   Entrez Gene: 19952   Ensembl: ENSG000001963617   OMIM: 6034585   UniProtKB: Q145763   

Export aliases for ELAVL3 gene to outside databases

Previous GC identifers: GC19M011694 GC19M011786 GC19M011409 GC19M011425 GC19M011426 GC19M011140


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELAVL3 Gene:
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three
RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific
RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic
encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively
spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for ELAVL3 Gene:
ELAVL3 (ELAV like neuron-specific RNA binding protein 3) is a protein-coding gene. Diseases associated with ELAVL3 include bladder carcinoma in situ, and sensory peripheral neuropathy. GO annotations related to this gene include AU-rich element binding and nucleotide binding. An important paralog of this gene is PABPC1L.

UniProtKB/Swiss-Prot: ELAV3_HUMAN, Q14576
Function: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via
RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance

Gene Wiki entry for ELAVL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELAVL3 gene promoter:
         Spz1   Tal-1   HTF   Lmo2   Olf-1   IRF-1   Nkx2-5   GATA-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELAVL3 promoter sequence
   Search Chromatin IP Primers for ELAVL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELAVL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ELAVL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELAVL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M011562:  view genomic region     (about GC identifiers)

Start:
11,562,141 bp from pter      End:
11,591,861 bp from pter
Size:
29,721 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ELAV3_HUMAN, Q14576 (See protein sequence)
Recommended Name: ELAV-like protein 3  
Size: 367 amino acids; 39547 Da
Secondary accessions: Q16135 Q96CL8 Q96QS9
Alternative splicing: 2 isoforms:  Q14576-1   Q14576-2   

Explore the universe of human proteins at neXtProt for ELAVL3: NX_Q14576

Explore proteomics data for ELAVL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys111
  • Modification sites at PhosphoSitePlus

  • See ELAVL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001411.2  NP_115657.2  

    ENSEMBL proteins: 
     ENSP00000352162   ENSP00000390878   ENSP00000467314  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR000504 RRM_dom
     IPR006548 ELAD_HUD_SF
     IPR002343 Hud_Sxl_RNA
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q14576

    ProtoNet protein and cluster: Q14576

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002343 Paraneoplastic encephalomyelitis antigen family signature


    UniProtKB/Swiss-Prot: ELAV3_HUMAN, Q14576
    Domain: RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA
    sequences (By similarity)
    Similarity: Belongs to the RRM elav family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    ELAVL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELAV3_HUMAN, Q14576
    Function: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via
    RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance

         Genatlas biochemistry entry for ELAVL3:
    Drosophila Elav-like 3 (embryonic,lethal,abnormal vision),onconeural specific,expressed at an early stage of
    neural development,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they
    become stabilized,translated or rapidly degraded,required for neuronal differentiation in the mammalian nervous
    system

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0017091AU-rich element binding IDA10710437
         
    ELAVL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ELAVL3:
     Decreased viability with cispl 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Elavl3):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    ELAVL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Elavl3tm1.1Rbd for ELAVL3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELAVL3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELAVL3

    miRNA
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    miRTarBase miRNAs that target ELAVL3:
    hsa-mir-26b-5p (MIRT028772)

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    Selected qRT-PCR Assays for microRNAs that regulate ELAVL3 (see all 94):
    hsa-miR-582-3p hsa-miR-1914* hsa-miR-1224-3p hsa-miR-938 hsa-miR-1260b hsa-miR-30d hsa-miR-3142 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton2
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELAVL3
    Interactions:

        Search GeneGlobe Interaction Network for ELAVL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ELAVL3 (Q145762, 3 ENSP000003521624) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL2Q129263, ENSP000003694604I2D: score=1 STRING: ENSP00000369460
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    MAST1Q9Y2H93, ENSP000002514724I2D: score=1 STRING: ENSP00000251472
    NOS3P294743, ENSP000002974944I2D: score=1 STRING: ENSP00000297494
    A2MP010233I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    ELAVL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELAVL3 (ELAV3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ELAVL3 gene (2 alternative transcripts): 
    NM_001420.3  NM_032281.2  

    Unigene Cluster for ELAVL3:

    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
    Hs.1701  [show with all ESTs]
    Unigene Representative Sequence: NM_001420
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359227(uc002mry.1) ENST00000438662(uc002mrx.1) ENST00000588853
    ENST00000592218
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ELAVL3 (see all 94):
    hsa-miR-582-3p hsa-miR-1914* hsa-miR-1224-3p hsa-miR-938 hsa-miR-1260b hsa-miR-30d hsa-miR-3142 hsa-miR-30a
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      QuantiFast Probe-based Assays in human, mouse, rat ELAVL3

    Additional mRNA sequence: 

    AL512714.1 AY034002.1 AY036909.1 BC011875.2 BC080533.1 L26405.1 

    8 DOTS entries:

    DT.112237  DT.100746296  DT.455715  DT.91658192  DT.121411101  DT.100705626  DT.91796955  DT.97846287 

    Selected AceView cDNA sequences (see all 144):

    CR623347 F02930 BM694032 BC080533 BC011875 AI369630 BM721960 BM709540 
    AI690046 F02739 BM710886 BM695835 BM727008 NM_032281 AL512714 AI091476 
    AI086399 BM666923 BQ894508 BM698118 BQ069786 BU195559 BI117426 BM680395 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELAVL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGAAAATA
    ELAVL3 Expression
    About this image


    ELAVL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Endothelial Cells Blood Brain Barrier
             Globus Pallidus
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     NULL (Uncategorized)
             Neural rosettes
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
    ELAVL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELAVL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1701

    UniProtKB/Swiss-Prot: ELAV3_HUMAN, Q14576
    Tissue specificity: Brain specific

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELAVL3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elavl31 , 5 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more1, 5 91.76(n)1
    99.44(a)1
      9 (8.07 cM)5
    155711  NM_010487.21  NP_034617.11 
     220150055 
    lizard
    (Anolis carolinensis)
    Reptilia ELAVL36
    ELAV like neuron-specific RNA binding protein 3
    84(a)
    1 ↔ 1
    2(78684169-78804893)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.108632 Transcribed sequence with moderate similarity to protein more 80.31(n)    BX742851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elavl31 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 80.87(n)
    89.57(a)
      30732  NM_131449.1  NP_571524.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fne3 RNA binding 57(a)
    (best of 5)
      11D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea exc-73 HUD 63(a)   II(9576218-9580987)   --


    ENSEMBL Gene Tree for ELAVL3 (if available)
    TreeFam Gene Tree for ELAVL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELAVL3 gene
    PABPC1L2  PABPC52  PABPC42  ELAVL12  PABPC4L2  ELAVL42  RBMS12  RBMS32  
    PABPC32  ELAVL22  RBMS22  PABPC12  
    4 SIMAP similar genes for ELAVL3 using alignment to 4 protein entries:     ELAV3_HUMAN (see all proteins):
    ELAVL4    ELAVL2    ELAVL1    HNRNPA1

    ELAVL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELAVL3 (see all 669)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3694000191,2
    C--11562295(+) TTTTT-/GTCTT 
    TTGTTTTG
    TCTTT
    2 -- ut310--------
    rs1383546121,2
    C--11562459(+) AGGGAC/TGTGGA 2 -- ut310--------
    rs1825334861,2
    --11562475(+) CAAGTC/TCCCCT 2 -- ut310--------
    rs1401605741,2
    --11562616(+) TCGGT-/GGGGGG 2 -- ut310--------
    rs1492566581,2
    --11562847(+) AACCAC/TGAGAA 2 -- ut310--------
    rs1503291911,2
    C--11562925(+) AAGAC-/AAGAGCA 2 -- ut310--------
    rs768805981,2
    C,F--11562996(+) ACGCCC/GCCGCG 2 -- ut311Minor allele frequency- G:0.02WA 118
    rs1864952401,2
    --11563072(+) TATAAA/GTAAAT 2 -- ut310--------
    rs1917755801,2
    --11563124(+) GAACAC/TTGTCG 2 -- ut310--------
    rs1835874421,2
    --11563147(+) GCAAAC/TCGGAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ELAVL3 (11562141 - 11591861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ELAVL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819522CNV Loss19587683
    nsv911066CNV Loss21882294
    dgv3731n71CNV Loss21882294
    nsv911062CNV Loss21882294
    nsv911065CNV Loss21882294
    nsv519802CNV Loss19592680
    nsv819321CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603458    OMIM disorders: --

    Selected diseases for ELAVL3 (see all 22):    
    About MalaCards
    bladder carcinoma in situ    sensory peripheral neuropathy    paraneoplastic cerebellar degeneration    encephalomyelitis
    cerebellar degeneration    paraneoplastic neurologic disorders    encephalitis    lambert-eaton myasthenic syndrome
    limbic encephalitis    bladder carcinoma    peripheral neuropathy    neuronitis
    neuropathy    lung cancer    transitional cell carcinoma    lateral sclerosis
    amyotrophic lateral sclerosis    neuroblastoma    endotheliitis    ischemia

    1 disease from the University of Copenhagen DISEASES database for ELAVL3:
    Urinary bladder cancer

    ELAVL3 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for ELAVL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraneoplastic encephalomyelitis 93.4 3 7541976 (2), 9288629 (1)
    sensory neuropathy 67.9 1 9288629 (1)
    small cell lung cancer 52.7 1 9288629 (1)
    cancer lung 40.9 1 7541976 (1)


    Export disorders for ELAVL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELAVL3 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with ELAVL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'- untranslated regions using a novel ELISA-based assay. (PubMed id 10710437)1, 2, 9 King P.H. (Nucleic Acids Res. 2000)
    2. A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. (PubMed id 7511893)1, 2, 9 Sakai K.... Steinman L. (Biochem. Biophys. Res. Commun. 1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique. (PubMed id 9799595)1, 3 Van Tine B.A....King P.H. (Genomics 1998)
    5. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PubMed id 12209604)1, 9 Behrends U.... Mautner J.M. (Int. J. Cancer 2002)
    6. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PubMed id 21163940)1 Soler-LA^pez M....Aloy P. (Genome Res. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (BMB Rep 2010)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1995 HGNC: 3314 AceView: ELAVL3 Ensembl:ENSG00000196361 euGenes: HUgn1995
    ECgene: ELAVL3 H-InvDB: ELAVL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELAVL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELAVL3 gene:
    Search GeneIP for patents involving ELAVL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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