Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ELAVL2 Gene

Aliases for ELAVL2 Gene

  • ELAV Like Neuron-Specific RNA Binding Protein 2 2 3
  • HUB 3 4 6
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2 (Hu Antigen B) 2 3
  • Nervous System-Specific RNA-Binding Protein Hel-N1 3 4
  • Hu-Antigen B 3 4
  • HELN1 3 6
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2 2
  • ELAV-Like Neuronal Protein 1 Isoform Hel-N2 3
  • ELAV-Like Neuronal Protein 1 4
  • ELAV-Like Protein 2 3
  • Hu Antigen B 2
  • HEL-N1 3

External Ids for ELAVL2 Gene

Previous GeneCards Identifiers for ELAVL2 Gene

  • GC09M024002
  • GC09M023680
  • GC09M023638

Summaries for ELAVL2 Gene

Entrez Gene Summary for ELAVL2 Gene

  • The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for ELAVL2 Gene

ELAVL2 (ELAV Like Neuron-Specific RNA Binding Protein 2) is a Protein Coding gene. Diseases associated with ELAVL2 include contagious pustular dermatitis. GO annotations related to this gene include nucleotide binding and mRNA 3-UTR binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for ELAVL2 Gene

  • Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3-UTR, the FOS 3-UTR and the ID 3-UTR

Gene Wiki entry for ELAVL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL2 Gene

Genomics for ELAVL2 Gene

Regulatory Elements for ELAVL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ELAVL2 Gene

23,690,099 bp from pter
23,826,344 bp from pter
136,246 bases
Minus strand

Genomic View for ELAVL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELAVL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL2 Gene

Proteins for ELAVL2 Gene

  • Protein details for ELAVL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ELAV-like protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DRK3
    • Q13235
    • Q59G15
    • Q8NEM4
    • Q9H1Q8

    Protein attributes for ELAVL2 Gene

    359 amino acids
    Molecular mass:
    39504 Da
    Quaternary structure:
    • Interacts with IGF2BP1.
    • Sequence=BAD92531.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ELAVL2 Gene


neXtProt entry for ELAVL2 Gene

Proteomics data for ELAVL2 Gene at MOPED

Post-translational modifications for ELAVL2 Gene

  • Ubiquitination at Lys74, Lys95, Lys111, and Lys209
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ELAVL2 Gene

Domains for ELAVL2 Gene

Gene Families for ELAVL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM elav family.
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL2: view

Function for ELAVL2 Gene

Molecular function for ELAVL2 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 2 (embryonic,lethal,abnormal vision),neuronal protein 1,expressed in brain,homolog to HEL-N1,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded,required for normal neuronal development in the embryonic CNS
UniProtKB/Swiss-Prot Function:
Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3-UTR, the FOS 3-UTR and the ID 3-UTR

Gene Ontology (GO) - Molecular Function for ELAVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003730 mRNA 3-UTR binding TAS 8158249
GO:0005515 protein binding IPI 17289661
genes like me logo Genes that share ontologies with ELAVL2: view

Animal Model Products

CRISPR Products

miRNA for ELAVL2 Gene

miRTarBase miRNAs that target ELAVL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAVL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ELAVL2 Gene

Localization for ELAVL2 Gene

Subcellular locations from

Jensen Localization Image for ELAVL2 Gene COMPARTMENTS Subcellular localization image for ELAVL2 gene
Compartment Confidence
nucleus 3
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ELAVL2 Gene

Pathways for ELAVL2 Gene

SuperPathways for ELAVL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 8158249
genes like me logo Genes that share ontologies with ELAVL2: view

No data available for Pathways by source for ELAVL2 Gene

Transcripts for ELAVL2 Gene

Unigene Clusters for ELAVL2 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAVL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - -

Relevant External Links for ELAVL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ELAVL2 Gene

mRNA expression in normal human tissues for ELAVL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.6), Brain - Anterior cingulate cortex (BA24) (8.4), Brain - Hypothalamus (6.4), Brain - Substantia nigra (4.7), and Brain - Cortex (4.4).

Protein differential expression in normal tissues for ELAVL2 Gene

This gene is overexpressed in Testis (22.0), Fetal Brain (16.3), Brain (10.5), and Ovary (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELAVL2 Gene

SOURCE GeneReport for Unigene cluster for ELAVL2 Gene Hs.166109

mRNA Expression by UniProt/SwissProt for ELAVL2 Gene

Tissue specificity: Brain; neural-specific
genes like me logo Genes that share expressions with ELAVL2: view

Expression partners for ELAVL2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for ELAVL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100296271 35
  • 97.59 (n)
  • 100 (a)
  • 92 (a)
(Canis familiaris)
Mammalia ELAVL2 35
  • 97.68 (n)
  • 100 (a)
  • 93 (a)
(Mus musculus)
Mammalia Elavl2 35
  • 95.2 (n)
  • 99.42 (a)
Elavl2 16
Elavl2 36
  • 96 (a)
(Pan troglodytes)
Mammalia ELAVL2 35
  • 99.72 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Elavl2 35
  • 95.17 (n)
  • 99.72 (a)
(Monodelphis domestica)
Mammalia ELAVL2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ELAVL2 36
  • 83 (a)
(Gallus gallus)
Aves ELAVL2 35
  • 89.11 (n)
  • 96.37 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia ELAVL2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl2 35
  • 83.72 (n)
  • 96.53 (a)
Str.19223 35
African clawed frog
(Xenopus laevis)
Amphibia elavl2-A-prov 35
(Danio rerio)
Actinopterygii elavl2 35
  • 76.72 (n)
  • 91.34 (a)
elavl2 36
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5213 37
  • 38 (a)
EG:132E8.1 37
  • 47 (a)
elav 37
  • 54 (a)
fne 37
  • 59 (a)
Sxl 37
  • 47 (a)
fne 35
  • 60.62 (n)
  • 66.77 (a)
CG5213 36
  • 34 (a)
elav 36
  • 39 (a)
fne 36
  • 60 (a)
Rbp9 36
  • 49 (a)
ssx 36
  • 26 (a)
Sxl 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009952 35
  • 61.35 (n)
  • 69.37 (a)
(Caenorhabditis elegans)
Secernentea exc-7 37
  • 65 (a)
exc-7 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 36
  • 54 (a)
Species with no ortholog for ELAVL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL2 Gene

Gene Tree for ELAVL2 (if available)
Gene Tree for ELAVL2 (if available)

Paralogs for ELAVL2 Gene

genes like me logo Genes that share paralogs with ELAVL2: view

Variants for ELAVL2 Gene

Sequence variations from dbSNP and Humsavar for ELAVL2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs702216 -- 23,792,086(+) tacac(A/C)atcat intron-variant
rs702217 -- 23,792,676(+) TTCTC(C/T)CAACT intron-variant
rs702218 -- 23,792,962(+) GTAGA(A/C)ACAGG intron-variant
rs702219 -- 23,803,533(+) AGCCA(C/G)ATCAG intron-variant
rs702220 -- 23,804,286(-) TTTCT(A/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL2 Gene

Variant ID Type Subtype PubMed ID
nsv892790 CNV Gain 21882294
nsv892791 CNV Gain 21882294
nsv510190 CNV Loss 20534489
nsv438098 CNV Loss 16468122
nsv892792 CNV Gain 21882294
nsv892793 CNV Gain 21882294
nsv892794 CNV Gain 21882294

Relevant External Links for ELAVL2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL2 Gene

Disorders for ELAVL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ELAVL2 Gene in MalaCards »

(1) Disease for ELAVL2 Gene

(1) University of Copenhagen DISEASES for ELAVL2 Gene

(6) Novoseek inferred disease relationships for ELAVL2 Gene

Disease -log(P) Hits PubMed IDs
paraneoplastic encephalomyelitis 91.3 3
medulloblastoma 53.9 2
lung carcinoma 35.5 3
cancer lung 26.6 3
tumors 0 3

Relevant External Links for ELAVL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ELAVL2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ELAVL2 Gene

Publications for ELAVL2 Gene

  1. Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. (PMID: 7972035) Gao F.B. … Keene J.D. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  2. Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization. (PMID: 8812435) Han J. … King P.H. (Genomics 1996) 2 3 23
  3. Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. (PMID: 8158249) King P.H. … Keene J.D. (J. Neurosci. 1994) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ELAVL2 Gene

Sources for ELAVL2 Gene

Back to Top