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Aliases for ELAVL2 Gene

Aliases for ELAVL2 Gene

  • ELAV Like Neuron-Specific RNA Binding Protein 2 2 3 5
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2 (Hu Antigen B) 2 3
  • Nervous System-Specific RNA-Binding Protein Hel-N1 3 4
  • Hu-Antigen B 3 4
  • HUB 3 4
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2 2
  • ELAV-Like Neuronal Protein 1 Isoform Hel-N2 3
  • ELAV-Like Neuronal Protein 1 4
  • Hu Antigen B 2
  • HEL-N1 3
  • HELN1 3

External Ids for ELAVL2 Gene

Previous GeneCards Identifiers for ELAVL2 Gene

  • GC09M024002
  • GC09M023680
  • GC09M023638

Summaries for ELAVL2 Gene

Entrez Gene Summary for ELAVL2 Gene

  • The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for ELAVL2 Gene

ELAVL2 (ELAV Like Neuron-Specific RNA Binding Protein 2) is a Protein Coding gene. Diseases associated with ELAVL2 include Contagious Pustular Dermatitis. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PABPC1L2A.

UniProtKB/Swiss-Prot for ELAVL2 Gene

  • Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3-UTR, the FOS 3-UTR and the ID 3-UTR.

Gene Wiki entry for ELAVL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL2 Gene

Genomics for ELAVL2 Gene

Regulatory Elements for ELAVL2 Gene

Enhancers for ELAVL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELAVL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELAVL2 Gene

Chromosome:
9
Start:
23,690,104 bp from pter
End:
23,850,706 bp from pter
Size:
160,603 bases
Orientation:
Minus strand

Genomic View for ELAVL2 Gene

Genes around ELAVL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL2 Gene

Proteins for ELAVL2 Gene

  • Protein details for ELAVL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12926-ELAV2_HUMAN
    Recommended name:
    ELAV-like protein 2
    Protein Accession:
    Q12926
    Secondary Accessions:
    • D3DRK3
    • Q13235
    • Q59G15
    • Q8NEM4
    • Q9H1Q8

    Protein attributes for ELAVL2 Gene

    Size:
    359 amino acids
    Molecular mass:
    39504 Da
    Quaternary structure:
    • Interacts with IGF2BP1.
    SequenceCaution:
    • Sequence=BAD92531.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ELAVL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELAVL2 Gene

Proteomics data for ELAVL2 Gene at MOPED

Post-translational modifications for ELAVL2 Gene

  • Ubiquitination at Lys 209
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ELAVL2 Gene

Domains & Families for ELAVL2 Gene

Gene Families for ELAVL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q12926

UniProtKB/Swiss-Prot:

ELAV2_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM elav family.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL2: view

Function for ELAVL2 Gene

Molecular function for ELAVL2 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 2 (embryonic,lethal,abnormal vision),neuronal protein 1,expressed in brain,homolog to HEL-N1,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded,required for normal neuronal development in the embryonic CNS
UniProtKB/Swiss-Prot Function:
Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3-UTR, the FOS 3-UTR and the ID 3-UTR.

Gene Ontology (GO) - Molecular Function for ELAVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ELAVL2: view
genes like me logo Genes that share phenotypes with ELAVL2: view

Animal Model Products

CRISPR Products

miRNA for ELAVL2 Gene

miRTarBase miRNAs that target ELAVL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELAVL2 Gene

Localization for ELAVL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELAVL2 Gene COMPARTMENTS Subcellular localization image for ELAVL2 gene
Compartment Confidence
nucleus 4
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ELAVL2 Gene

Pathways & Interactions for ELAVL2 Gene

genes like me logo Genes that share pathways with ELAVL2: view

Pathways by source for ELAVL2 Gene

Gene Ontology (GO) - Biological Process for ELAVL2 Gene

None

No data available for SIGNOR curated interactions for ELAVL2 Gene

Drugs & Compounds for ELAVL2 Gene

No Compound Related Data Available

Transcripts for ELAVL2 Gene

Unigene Clusters for ELAVL2 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - -

Relevant External Links for ELAVL2 Gene

GeneLoc Exon Structure for
ELAVL2
ECgene alternative splicing isoforms for
ELAVL2

Expression for ELAVL2 Gene

mRNA expression in normal human tissues for ELAVL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.6), Brain - Anterior cingulate cortex (BA24) (x8.4), Brain - Hypothalamus (x6.4), Brain - Substantia nigra (x4.7), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for ELAVL2 Gene

This gene is overexpressed in Testis (22.0), Fetal Brain (16.3), Brain (10.5), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELAVL2 Gene



SOURCE GeneReport for Unigene cluster for ELAVL2 Gene Hs.166109

mRNA Expression by UniProt/SwissProt for ELAVL2 Gene

Q12926-ELAV2_HUMAN
Tissue specificity: Brain; neural-specific.
genes like me logo Genes that share expression patterns with ELAVL2: view

Protein tissue co-expression partners for ELAVL2 Gene

- Elite partner

Primer Products

Orthologs for ELAVL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100296271 35
  • 97.59 (n)
  • 100 (a)
ELAVL2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELAVL2 35
  • 97.68 (n)
  • 100 (a)
ELAVL2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elavl2 35
  • 95.2 (n)
  • 99.42 (a)
Elavl2 16
Elavl2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELAVL2 35
  • 99.72 (n)
  • 100 (a)
ELAVL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elavl2 35
  • 95.17 (n)
  • 99.72 (a)
oppossum
(Monodelphis domestica)
Mammalia ELAVL2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL2 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELAVL2 35
  • 89.11 (n)
  • 96.37 (a)
ELAVL2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELAVL2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl2 35
  • 83.72 (n)
  • 96.53 (a)
Str.19223 35
African clawed frog
(Xenopus laevis)
Amphibia elavl2-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii elavl2 35
  • 76.72 (n)
  • 91.34 (a)
elavl2 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5213 37
  • 38 (a)
EG:132E8.1 37
  • 47 (a)
elav 37
  • 54 (a)
fne 37
  • 59 (a)
Sxl 37
  • 47 (a)
fne 35
  • 60.62 (n)
  • 66.77 (a)
CG5213 36
  • 34 (a)
ManyToMany
elav 36
  • 39 (a)
ManyToMany
fne 36
  • 60 (a)
ManyToMany
Rbp9 36
  • 49 (a)
ManyToMany
ssx 36
  • 26 (a)
ManyToMany
Sxl 36
  • 29 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009952 35
  • 61.35 (n)
  • 69.37 (a)
worm
(Caenorhabditis elegans)
Secernentea exc-7 37
  • 65 (a)
exc-7 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 36
  • 54 (a)
OneToMany
Species with no ortholog for ELAVL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL2 Gene

ENSEMBL:
Gene Tree for ELAVL2 (if available)
TreeFam:
Gene Tree for ELAVL2 (if available)

Paralogs for ELAVL2 Gene

genes like me logo Genes that share paralogs with ELAVL2: view

Variants for ELAVL2 Gene

Sequence variations from dbSNP and Humsavar for ELAVL2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs702216 -- 23,792,086(+) tacac(A/C)atcat intron-variant
rs702217 -- 23,792,676(+) TTCTC(C/T)CAACT intron-variant
rs702218 -- 23,792,962(+) GTAGA(A/C)ACAGG intron-variant
rs702219 -- 23,803,533(+) AGCCA(C/G)ATCAG intron-variant
rs702220 -- 23,804,286(-) TTTCT(A/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL2 Gene

Variant ID Type Subtype PubMed ID
nsv892790 CNV Gain 21882294
nsv892791 CNV Gain 21882294
nsv510190 CNV Loss 20534489
nsv438098 CNV Loss 16468122
nsv892792 CNV Gain 21882294
nsv892793 CNV Gain 21882294
nsv892794 CNV Gain 21882294

Variation tolerance for ELAVL2 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELAVL2 Gene

Human Gene Mutation Database (HGMD)
ELAVL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL2 Gene

Disorders for ELAVL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ELAVL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
contagious pustular dermatitis
  • ecthyma contagiosum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ELAVL2

Genetic Association Database (GAD)
ELAVL2
Human Genome Epidemiology (HuGE) Navigator
ELAVL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELAVL2
genes like me logo Genes that share disorders with ELAVL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL2 Gene

Publications for ELAVL2 Gene

  1. Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization. (PMID: 8812435) Han J. … King P.H. (Genomics 1996) 2 3 23 67
  2. Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. (PMID: 8907704) Gao F.B. … Keene J.D. (J. Cell. Sci. 1996) 3 23
  3. Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. (PMID: 7972035) Gao F.B. … Keene J.D. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ELAVL2 Gene

Sources for ELAVL2 Gene

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