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ELAVL2 Gene

protein-coding   GIFtS: 60
GCID: GC09M023690

ELAV Like Neuron-Specific RNA Binding Protein 2

(Previous names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like...)
  See ELAVL2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ELAV Like Neuron-Specific RNA Binding Protein 21 2     Hu Antigen B1
HUB2 3 5     HEL-N12
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2 (Hu Antigen B)1 2     ELAV-Like Neuronal Protein 1 Isoform Hel-N22
Hu-Antigen B2 3     ELAV-Like Protein 22
Nervous System-Specific RNA-Binding Protein Hel-N12 3     HuB3
HELN12 5     ELAV-Like Neuronal Protein 13
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 21     

External Ids:    HGNC: 33131   Entrez Gene: 19932   Ensembl: ENSG000001071057   OMIM: 6016735   UniProtKB: Q129263   

Export aliases for ELAVL2 gene to outside databases

Previous GC identifers: GC09M024002 GC09M023680 GC09M023638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELAVL2 Gene:
The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3'
UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA.
Three transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jan
2010)

GeneCards Summary for ELAVL2 Gene:
ELAVL2 (ELAV like neuron-specific RNA binding protein 2) is a protein-coding gene. Diseases associated with ELAVL2 include contagious pustular dermatitis. GO annotations related to this gene include mRNA 3'-UTR binding and nucleotide binding. An important paralog of this gene is PABPC1L.

UniProtKB/Swiss-Prot: ELAV2_HUMAN, Q12926
Function: Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR

Gene Wiki entry for ELAVL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELAVL2 gene promoter:
         ER-alpha   Max1   FOXD3   GATA-1   FAC1   CBF-A   POU2F1   POU2F1a   CBF(2)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELAVL2 promoter sequence
   Search Chromatin IP Primers for ELAVL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELAVL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p21

ELAVL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELAVL2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M023690:  view genomic region     (about GC identifiers)

Start:
23,690,102 bp from pter      End:
23,826,335 bp from pter
Size:
136,234 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ELAV2_HUMAN, Q12926 (See protein sequence)
Recommended Name: ELAV-like protein 2  
Size: 359 amino acids; 39504 Da
Subunit: Interacts with IGF2BP1
Sequence caution: Sequence=BAD92531.1; Type=Erroneous initiation;
Secondary accessions: D3DRK3 Q13235 Q59G15 Q8NEM4 Q9H1Q8
Alternative splicing: 2 isoforms:  Q12926-1   Q12926-2   

Explore the universe of human proteins at neXtProt for ELAVL2: NX_Q12926

Explore proteomics data for ELAVL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys74, Lys95, Lys111, Lys209
  • Modification sites at PhosphoSitePlus

  • See ELAVL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164666.1  NP_001164668.1  NP_004423.2  

    ENSEMBL proteins: 
     ENSP00000369453   ENSP00000223951   ENSP00000369460   ENSP00000391757   ENSP00000412602  
     ENSP00000380479   ENSP00000440998  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR000504 RRM_dom
     IPR006548 ELAD_HUD_SF
     IPR002343 Hud_Sxl_RNA
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q12926

    ProtoNet protein and cluster: Q12926

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002343 Paraneoplastic encephalomyelitis antigen family signature


    UniProtKB/Swiss-Prot: ELAV2_HUMAN, Q12926
    Similarity: Belongs to the RRM elav family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Find genes that share domains with ELAVL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELAV2_HUMAN, Q12926
    Function: Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR

         Genatlas biochemistry entry for ELAVL2:
    Drosophila Elav-like 2 (embryonic,lethal,abnormal vision),neuronal protein 1,expressed in brain,homolog to
    HEL-N1,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become
    stabilized,translated or rapidly degraded,required for normal neuronal development in the embryonic CNS

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003730mRNA 3'-UTR binding TAS8158249
    GO:0005515protein binding IPI17289661
         
    Find genes that share ontologies with ELAVL2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Elavl2 (no phenotypes)

    Find genes that share phenotypes with ELAVL2           About GenesLikeMe

    Animal Models:
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    Block miRNA regulation of human, mouse, rat ELAVL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELAVL2 (see all 174):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-106a hsa-miR-3653 hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidELAVL2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELAVL2
    Interactions:

        Search GeneGlobe Interaction Network for ELAVL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ELAVL2 (Q129263 ENSP000003694604) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL3Q145763, ENSP000003521624I2D: score=1 STRING: ENSP00000352162
    ELAVL4P263783, ENSP000003495944I2D: score=1 STRING: ENSP00000349594
    HNRNPABQ997293, ENSP000003511084I2D: score=1 STRING: ENSP00000351108
    HOXC9P312743, ENSP000003028364I2D: score=1 STRING: ENSP00000302836
    RBFOX2O432513, ENSP000004130354I2D: score=1 STRING: ENSP00000413035
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS8158249

    Find genes that share ontologies with ELAVL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELAVL2 (ELAV2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ELAVL2 gene (3 alternative transcripts): 
    NM_001171195.1  NM_001171197.1  NM_004432.3  

    Unigene Cluster for ELAVL2:

    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
    Hs.166109  [show with all ESTs]
    Unigene Representative Sequence: NM_004432
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380110(uc003zps.3) ENST00000223951 ENST00000380117 ENST00000423281
    ENST00000440102 ENST00000462649 ENST00000397312(uc003zpu.3 uc003zpv.3 uc003zpw.3)
    ENST00000544538(uc003zpt.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ELAVL2 (see all 174):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-106a hsa-miR-3653 hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p hsa-miR-200b
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    Additional mRNA sequence: 

    AB209294.1 BC030692.1 BC035004.1 BC042393.1 

    9 DOTS entries:

    DT.91749013  DT.452065  DT.101981906  DT.121202018  DT.95244879  DT.121202010  DT.91938589  DT.95308703 
    DT.107784 

    Selected AceView cDNA sequences (see all 53):

    AA935601 Z41433 BF439651 BX646418 BX105616 Z45789 AW183530 BM553123 
    AA961066 AI453076 BC042393 CD722381 AL041228 AI028574 D61361 AI990307 
    AA628633 BM727226 BI458470 AA393346 AI376075 BC030692 AA431478 AI150282 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
    SP1:              -     -     -           -                                                         
    SP2:              -     -     -           -                                                         
    SP3:              -     -     -           -                                   -                     
    SP4:                          -           -                                   -                     
    SP5:                                      -                                                         


    ECgene alternative splicing isoforms for ELAVL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELAVL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAGTACAT
    ELAVL2 Expression
    About this image


    ELAVL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Gonad (Reproductive System)    fully expand to see all 2 entries
             Primordial Germ Cells Primitive Gonad
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
    ELAVL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELAVL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.166109

    UniProtKB/Swiss-Prot: ELAV2_HUMAN, Q12926
    Tissue specificity: Brain; neural-specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELAVL2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elavl21 , 5 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more1, 5 95.2(n)1
    99.42(a)1
      4 (42.36 cM)5
    155691  NM_207686.11  NP_997569.11 
     912507635 
    chicken
    (Gallus gallus)
    Aves ELAVL21 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 89.11(n)
    96.37(a)
      770158  XM_004949539.1  XP_004949596.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELAVL26
    ELAV like neuron-specific RNA binding protein 2
    86(a)
    1 ↔ 1
    2(60511637-60669645)
    African clawed frog
    (Xenopus laevis)
    Amphibia elavl2-A-prov2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 82.49(n)    U17597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elavl21 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 76.72(n)
    91.34(a)
      431719  NM_001002172.2  NP_001002172.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta fne1 , 3 RNA binding3
    found in neurons1
    59(a)
    (best of 5)3
    60.62(n)1
    66.77(a)1
      11D43
    322451  NM_001258718.21  NP_001245647.11 
    worm
    (Caenorhabditis elegans)
    Secernentea exc-73 HUD 65(a)   II(9576218-9580987)   --


    ENSEMBL Gene Tree for ELAVL2 (if available)
    TreeFam Gene Tree for ELAVL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELAVL2 gene
    PABPC1L2  PABPC52  PABPC42  ELAVL12  PABPC4L2  ELAVL42  RBMS12  ELAVL32  
    RBMS32  PABPC32  RBMS22  PABPC12  
    Selected SIMAP similar genes for ELAVL2 using alignment to 4 protein entries:     ELAV2_HUMAN (see all proteins) (see all similar genes):
    ELAVL4    ELAVL1    ELAVL3    HNRNPM    PABPC4L    PABPC1
    CIRBP    PABPC4    RBMX    MSI2    RBMS3    CELF2
    CELF5    PABPC1L    TIA1    RBMS2    CELF4    PABPC1L2A

    Find genes that share paralogs with ELAVL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELAVL2 (see all 3119)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1123223761,2
    C--23647044(+) ACAGCA/-AAAAT 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs785110991,2
    C--23656407(+) TTTTTT/CCCCAA 3 -- int11Minor allele frequency- C:0.00NA 2
    rs1414775951,2
    C--23656407(+) TTTTT-/CCCCAA 3 -- int10--------
    rs112907321,2
    C--23657802(+) TCCGA-/TTTTTT 3 -- int1 trp30--------
    rs787835071,2
    C,F--23661005(+) CTCTTG/AACAAT 3 -- ds50012Minor allele frequency- A:0.11CSA WA 120
    rs772069351,2
    C,F--23661034(+) AGTAAC/TTTTCA 3 -- ds50012Minor allele frequency- T:0.11CSA WA 120
    rs49778861,2
    C,F,A,H--23661089(+) GAAGCC/AGAGTA 3 -- ds500132Minor allele frequency- A:0.15EA NA NS WA 3118
    rs1382911201,2
    --23661090(+) AAGCCA/GAGTAA 3 -- ds50010--------
    rs1151207151,2
    F--23661247(+) GAGAAT/GTACTC 3 -- ds50011Minor allele frequency- G:0.02WA 118
    rs768533971,2
    C,F--23661248(+) AGAATT/AACTCA 3 -- ds50011Minor allele frequency- A:0.19WA 118

    HapMap Linkage Disequilibrium report for ELAVL2 (23690102 - 23826335 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ELAVL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510190CNV Loss20534489
    nsv438098CNV Loss16468122
    nsv892792CNV Gain21882294
    nsv892790CNV Gain21882294
    nsv892794CNV Gain21882294
    nsv892791CNV Gain21882294
    nsv892793CNV Gain21882294

    Human Gene Mutation Database (HGMD): ELAVL2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELAVL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ELAVL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601673    OMIM disorders: --

    1 disease for ELAVL2:    
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    contagious pustular dermatitis

    1 disease from the University of Copenhagen DISEASES database for ELAVL2:
    Contagious pustular dermatitis

    Find genes that share disorders with ELAVL2           About GenesLikeMe

    6 Novoseek inferred disease relationships for ELAVL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraneoplastic encephalomyelitis 91.3 3 7541976 (2), 8497264 (1)
    medulloblastoma 53.9 2 8907704 (1), 9988134 (1)
    lung carcinoma 35.5 3 8053656 (2), 8619556 (1)
    cancer lung 26.6 3 7541976 (1), 9393760 (1), 8053656 (1)
    tumors 0 4 9815574 (1), 9393760 (1), 10049360 (1)
    carcinoma 0 1 8053656 (1)

    Genetic Association Database (GAD): ELAVL2
    Human Genome Epidemiology (HuGE) Navigator: ELAVL2 (1 document)

    Export disorders for ELAVL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELAVL2 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with ELAVL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization. (PubMed id 8812435)1, 3, 9 Han J....King P.H. (Genomics 1996)
    2. Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. (PubMed id 7972035)1, 2, 9 Gao F.B.... Keene J.D. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    3. A Bayesian approach to genetic association studies with family-based designs. (PubMed id 20818722)1, 4 Naylor M.G....Lange C. (Genet. Epidemiol. 2010)
    4. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
    5. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. (PubMed id 8158249)1, 2 King P.H.... Keene J.D. (J. Neurosci. 1994)
    9. Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. (PubMed id 8907704)1, 9 Gao F.B. and Keene J.D. (J. Cell. Sci. 1996)
    10. Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (PubMed id 23512105)1 Beaty T.H....Ruczinski I. (Hum. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1993 HGNC: 3313 AceView: ELAVL2 Ensembl:ENSG00000107105 euGenes: HUgn1993
    ECgene: ELAVL2 H-InvDB: ELAVL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELAVL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELAVL2 gene:
    Search GeneIP for patents involving ELAVL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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