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Aliases for ELAVL1 Gene

Aliases for ELAVL1 Gene

  • ELAV Like RNA Binding Protein 1 2 3 5
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) 2 3
  • Hu Antigen R 2 3
  • Hu-Antigen R 3 4
  • HUR 3 4
  • Embryonic Lethal, Abnormal Vision, Drosophila, Homolog-Like 1 3
  • Embryonic Lethal 2
  • Abnormal Vision 2
  • Homolog-Like 1 2
  • Drosophila 2
  • ELAV1 3
  • MelG 3
  • Hua 3

External Ids for ELAVL1 Gene

Previous HGNC Symbols for ELAVL1 Gene

  • HUR

Previous GeneCards Identifiers for ELAVL1 Gene

  • GC19M007986
  • GC19M008132
  • GC19M007933
  • GC19M007929
  • GC19M008023
  • GC19M007693

Summaries for ELAVL1 Gene

Entrez Gene Summary for ELAVL1 Gene

  • The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

GeneCards Summary for ELAVL1 Gene

ELAVL1 (ELAV Like RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with ELAVL1 include periampullary adenocarcinoma. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBMS2.

UniProtKB/Swiss-Prot for ELAVL1 Gene

  • RNA-binding protein that binds to the 3-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5-UUUU[AG]UUU-3 motif in vitro. With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.

Gene Wiki entry for ELAVL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL1 Gene

Genomics for ELAVL1 Gene

Regulatory Elements for ELAVL1 Gene

Promoters for ELAVL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ELAVL1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ELAVL1 gene promoter:

Genomic Location for ELAVL1 Gene

Chromosome:
19
Start:
7,958,573 bp from pter
End:
8,445,041 bp from pter
Size:
486,469 bases
Orientation:
Minus strand

Genomic View for ELAVL1 Gene

Genes around ELAVL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL1 Gene

Proteins for ELAVL1 Gene

  • Protein details for ELAVL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15717-ELAV1_HUMAN
    Recommended name:
    ELAV-like protein 1
    Protein Accession:
    Q15717
    Secondary Accessions:
    • B4DVB8
    • Q53XN6
    • Q9BTT1

    Protein attributes for ELAVL1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36092 Da
    Quaternary structure:
    • Interacts with ANP32A (By similarity). Interact with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with ANP32A, AGO1 and AGO2. Interacts with IGF2BP2 and IGF2BP3.

    Three dimensional structures from OCA and Proteopedia for ELAVL1 Gene

    Alternative splice isoforms for ELAVL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELAVL1 Gene

Proteomics data for ELAVL1 Gene at MOPED

Post-translational modifications for ELAVL1 Gene

  • Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
  • Phosphorylated by MAPKAPK2.
  • Ubiquitination at Lys 50, Lys 55, Lys 72, Lys 104, Lys 120, Lys 191, Lys 313, and Lys 320
  • Modification sites at PhosphoSitePlus

Other Protein References for ELAVL1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ELAVL1 (HuR)

No data available for DME Specific Peptides for ELAVL1 Gene

Domains & Families for ELAVL1 Gene

Gene Families for ELAVL1 Gene

Suggested Antigen Peptide Sequences for ELAVL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15717

UniProtKB/Swiss-Prot:

ELAV1_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM elav family.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL1: view

Function for ELAVL1 Gene

Molecular function for ELAVL1 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 1 (embryonic,lethal,abnormal vision),HuR,widely expressed,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded
UniProtKB/Swiss-Prot Function:
RNA-binding protein that binds to the 3-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5-UUUU[AG]UUU-3 motif in vitro. With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.

Gene Ontology (GO) - Molecular Function for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003729 mRNA binding TAS 10660597
GO:0019901 protein kinase binding IPI 14517288
GO:0042803 protein homodimerization activity IPI 17632515
genes like me logo Genes that share ontologies with ELAVL1: view
genes like me logo Genes that share phenotypes with ELAVL1: view

Animal Models for ELAVL1 Gene

MGI Knock Outs for ELAVL1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL1 Gene

Localization for ELAVL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELAVL1 Gene

Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELAVL1 Gene COMPARTMENTS Subcellular localization image for ELAVL1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ELAVL1: view

Pathways & Interactions for ELAVL1 Gene

genes like me logo Genes that share pathways with ELAVL1: view

Pathways by source for ELAVL1 Gene

SIGNOR curated interactions for ELAVL1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ELAVL1 Gene

None

Drugs & Compounds for ELAVL1 Gene

(11) Drugs for ELAVL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for ELAVL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELAVL1: view

Transcripts for ELAVL1 Gene

Unigene Clusters for ELAVL1 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL1 Gene

No ASD Table

Relevant External Links for ELAVL1 Gene

GeneLoc Exon Structure for
ELAVL1
ECgene alternative splicing isoforms for
ELAVL1

Expression for ELAVL1 Gene

mRNA expression in normal human tissues for ELAVL1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELAVL1 Gene



SOURCE GeneReport for Unigene cluster for ELAVL1 Gene Hs.184492

mRNA Expression by UniProt/SwissProt for ELAVL1 Gene

Q15717-ELAV1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ELAVL1: view

Protein tissue co-expression partners for ELAVL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ELAVL1 Gene

Orthologs for ELAVL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELAVL1 35
  • 93.15 (n)
  • 99.39 (a)
ELAVL1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELAVL1 35
  • 93.25 (n)
  • 99.69 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Elavl1 35
  • 91 (n)
  • 98.47 (a)
Elavl1 16
Elavl1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELAVL1 35
  • 99.69 (n)
  • 100 (a)
ELAVL1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elavl1 35
  • 90.59 (n)
  • 98.47 (a)
oppossum
(Monodelphis domestica)
Mammalia ELAVL1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELAVL1 35
  • 86.3 (n)
  • 98.47 (a)
ELAVL1 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl1 35
  • 79.24 (n)
  • 92.94 (a)
Str.2596 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5177 35
zebrafish
(Danio rerio)
Actinopterygii elavl1 35
hug 35
  • 74.53 (n)
  • 82.92 (a)
elavl1 36
  • 81 (a)
OneToMany
hug 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5213 37
  • 35 (a)
EG:132E8.1 37
  • 46 (a)
elav 37
  • 52 (a)
fne 37
  • 58 (a)
Sxl 37
  • 44 (a)
elav 36
  • 37 (a)
ManyToMany
fne 36
  • 56 (a)
ManyToMany
Rbp9 36
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea exc-7 37
  • 54 (a)
exc-7 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 36
  • 48 (a)
OneToMany
Species with no ortholog for ELAVL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL1 Gene

ENSEMBL:
Gene Tree for ELAVL1 (if available)
TreeFam:
Gene Tree for ELAVL1 (if available)

Paralogs for ELAVL1 Gene

(14) SIMAP similar genes for ELAVL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ELAVL1: view

Variants for ELAVL1 Gene

Sequence variations from dbSNP and Humsavar for ELAVL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10818 -- 7,962,433(+) AATCA(A/C)AGGTT utr-variant-3-prime
rs14394 -- 7,963,660(-) TTTGG(C/T)GCCGT reference, synonymous-codon
rs14610 -- 7,962,349(+) CAAAA(A/G)AAAAT utr-variant-3-prime
rs745123 -- 7,968,647(-) TAGCC(A/G)GGAAC intron-variant
rs890905 -- 7,968,690(-) GACGG(G/T)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL1 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
dgv3716n71 CNV Loss 21882294
nsv833734 CNV Loss 17160897
nsv138435 CNV Insertion 16902084
nsv910994 CNV Loss 21882294

Variation tolerance for ELAVL1 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELAVL1 Gene

HapMap Linkage Disequilibrium report
ELAVL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL1 Gene

Disorders for ELAVL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ELAVL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
periampullary adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ELAVL1

Genetic Association Database (GAD)
ELAVL1
Human Genome Epidemiology (HuGE) Navigator
ELAVL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELAVL1
genes like me logo Genes that share disorders with ELAVL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL1 Gene

Publications for ELAVL1 Gene

  1. Cloning and characterization of HuR, a ubiquitously expressed Elav- like protein. (PMID: 8626503) Ma W.-J. … Furneaux H.M. (J. Biol. Chem. 1996) 2 3 4 67
  2. Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT. (PMID: 19917608) Fernau N.S. … Klotz L.O. (J. Biol. Chem. 2010) 3 23
  3. Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes. (PMID: 19931428) Papadopoulou C. … Guialis A. (Biochim. Biophys. Acta 2010) 3 23
  4. Transcriptional control of human antigen R by bone morphogenetic protein. (PMID: 20018854) Jeyaraj S.C. … Lee B.S. (J. Biol. Chem. 2010) 3 23
  5. Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR. (PMID: 20086103) Doller A. … Eberhardt W. (Mol. Cell. Biol. 2010) 3 23

Products for ELAVL1 Gene

Sources for ELAVL1 Gene

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