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ELAVL1 Gene

protein-coding   GIFtS: 61
GCID: GC19M008023

ELAV Like RNA Binding Protein 1

(Previous names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like...)
(Previous symbol: HUR)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ELAV Like RNA Binding Protein 11 2     Homolog-Like 11
HUR1 2 3 5     ELAV12
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R)1 2     Hua2
Hu Antigen R1 2     MelG2
Hu-Antigen R2 3     ELAV-Like Protein 12
Abnormal Vision1     Embryonic Lethal, Abnormal Vision, Drosophila, Homolog-Like 12
drosophila1     HuR3
Embryonic Lethal1     

External Ids:    HGNC: 33121   Entrez Gene: 19942   Ensembl: ENSG000000660447   OMIM: 6034665   UniProtKB: Q157173   

Export aliases for ELAVL1 gene to outside databases

Previous GC identifers: GC19M007986 GC19M008132 GC19M007933 GC19M007929 GC19M007693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELAVL1 Gene:
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA
recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs.
AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family
of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of
biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in
many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. (provided by RefSeq,
Sep 2012)

GeneCards Summary for ELAVL1 Gene:
ELAVL1 (ELAV like RNA binding protein 1) is a protein-coding gene. Diseases associated with ELAVL1 include paraneoplastic neurologic disorders, and alk-positive anaplastic large cell lymphoma. GO annotations related to this gene include protein kinase binding and RNA binding. An important paralog of this gene is PABPC1L.

UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717
Function: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in
embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by
N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich
elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3
mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA,
AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the
3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53
expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA

Gene Wiki entry for ELAVL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELAVL1 gene promoter:
         AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ELAVL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELAVL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ELAVL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELAVL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M008023:  view genomic region     (about GC identifiers)

Start:
8,023,457 bp from pter      End:
8,070,543 bp from pter
Size:
47,087 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717 (See protein sequence)
Recommended Name: ELAV-like protein 1  
Size: 326 amino acids; 36092 Da
Subunit: Interacts with ANP32A (By similarity). Interact with ZNF385A; the interaction is indirect and
mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least
composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.
Interacts with ANP32A, AGO1 and AGO2. Interacts with IGF2BP2 and IGF2BP3
4 PDB 3D structures from and Proteopedia for ELAVL1:
3HI9 (3D)        4ED5 (3D)        4EGL (3D)        4FXV (3D)    
Secondary accessions: Q53XN6 Q9BTT1

Explore the universe of human proteins at neXtProt for ELAVL1: NX_Q15717

Explore proteomics data for ELAVL1 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPKAPK21
  • Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge1
  • Ubiquitination2 at Lys50, Lys55, Lys72, Lys92, Lys104, Lys120, Lys191, Lys313, Lys320
  • Modification sites at PhosphoSitePlus

  • See ELAVL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001410.2  
    ENSEMBL proteins: 
     ENSP00000385269   ENSP00000471011   ENSP00000472197   ENSP00000470727   ENSP00000264073  
    Reactome Protein details: Q15717

    ELAVL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ELAVL1

    ELAVL1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ELAVL1
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    ELAVL1 Assay Products:

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    Cloud-Clone Corp. CLIAs for ELAVL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR000504 RRM_dom
     IPR006548 ELAD_HUD_SF
     IPR002343 Hud_Sxl_RNA
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q15717

    ProtoNet protein and cluster: Q15717

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002343 Paraneoplastic encephalomyelitis antigen family signature


    UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717
    Similarity: Belongs to the RRM elav family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    ELAVL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELAV1_HUMAN, Q15717
    Function: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in
    embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by
    N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich
    elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3
    mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA,
    AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the
    3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53
    expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA

         Genatlas biochemistry entry for ELAVL1:
    Drosophila Elav-like 1 (embryonic,lethal,abnormal vision),HuR,widely expressed,shuttling the ERG class of mRNA to
    the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA19561594
    GO:0003725double-stranded RNA binding IDA--
    GO:0003729mRNA binding TAS10660597
         
    ELAVL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ELAVL1:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Elavl1) (see all 17):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  normal  reproductive system  respiratory system 

    ELAVL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ELAVL1: Elavl1tm1.1Thla Elavl1tm1.2Dkon

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELAVL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ELAVL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELAVL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELAVL1

    miRNA
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    miRTarBase miRNAs that target ELAVL1:
    hsa-mir-125a-5p (MIRT005421), hsa-mir-93-5p (MIRT048754), hsa-mir-340-5p (MIRT019606), hsa-mir-519c-3p (MIRT003732), hsa-mir-519b-3p (MIRT003731), hsa-mir-519a-3p (MIRT003733)

    Block miRNA regulation of human, mouse, rat ELAVL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELAVL1 (see all 127):
    hsa-miR-124* hsa-miR-579 hsa-miR-548j hsa-miR-582-3p hsa-miR-26a-2* hsa-miR-3152-3p hsa-miR-607 hsa-miR-300
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ELAVL1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ELAVL1 (NM_001419)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELAVL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELAVL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELAV1_HUMAN, Q15717: Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by
    MAPKAPK2
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14517288
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA14517288
    GO:0005829cytosol TAS--

    ELAVL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELAVL1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Stabilization of mRNA by HuR0.00
    2Gene Expression
    Gene Expression0.40
    3Toll Comparative Pathway
    iNOS Signaling0.34
    4Translational Control
    Translational Control
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ELAVL1
        iNOS Signaling

    1 Cell Signaling Technology (CST) Pathway for ELAVL1
        Translational Control

    1 BioSystems Pathway for ELAVL1
        AMPK signaling

    1 Reactome Pathway for ELAVL1
        HuR stabilizes mRNA



    ELAVL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELAVL1
    Interactions:

        GeneGlobe Interaction Network for ELAVL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ELAVL1 (Q157171, 2, 3 ENSP000003852694) via UniProtKB, MINT, STRING, and/or I2D (see all 2435)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5206079 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    KPNA1P522942, 3, ENSP000003437014MINT-7945693 I2D: score=1 STRING: ENSP00000343701
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    SREK1Q8WXA92, 3, ENSP000003345384MINT-7947479 I2D: score=1 STRING: ENSP00000334538
    TNPO1Q929732, 3, ENSP000003367124MINT-7947479 I2D: score=1 STRING: ENSP00000336712
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation ----
    GO:0007275multicellular organismal development TAS9003489
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    ELAVL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELAVL1 (ELAV1)

    Selected Novoseek inferred chemical compound relationships for ELAVL1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 68.7 10 14633672 (1), 11018049 (1), 11565755 (1), 18202756 (1) (see all 6)
    adenine 44.6 9 16289864 (2), 11280780 (2), 14729623 (1), 16788138 (1) (see all 6)
    vegf 40.9 30 9497373 (5), 16306087 (3), 15707649 (3), 16170373 (2) (see all 12)
    adenylate 31.3 8 16714065 (2), 17127772 (1), 10859327 (1), 17581403 (1) (see all 5)
    uridine 22.8 4 11280780 (2), 16890199 (1)
    prostaglandin 4.86 1 19208339 (1)
    dihydrotestosterone 2.18 8 11356683 (3), 15325278 (1)
    glucose 1.8 1 11741601 (1)
    infliximab 1.55 3 17599736 (3)
    atp 0 22 16788138 (4), 17392515 (3), 14523003 (1), 17466948 (1) (see all 6)



    ELAVL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ELAVL1 gene: 
    NM_001419.2  

    Unigene Cluster for ELAVL1:

    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
    Hs.184492  [show with all ESTs]
    Unigene Representative Sequence: NM_001419
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407627(uc002mjb.3) ENST00000596154 ENST00000596459 ENST00000593807
    ENST00000595499 ENST00000351593
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate ELAVL1 (see all 127):
    hsa-miR-124* hsa-miR-579 hsa-miR-548j hsa-miR-582-3p hsa-miR-26a-2* hsa-miR-3152-3p hsa-miR-607 hsa-miR-300
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      QuantiTect SYBR Green Assays in human, mouse, rat ELAVL1
      QuantiFast Probe-based Assays in human, mouse, rat ELAVL1

    Additional mRNA sequence: 

    AK096659.1 AK301013.1 AL713686.1 BC003376.2 BT009793.1 BX647856.1 U38175.1 

    10 DOTS entries:

    DT.318483  DT.100818939  DT.95127039  DT.95274284  DT.121485795  DT.430165  DT.121485798  DT.91850162 
    DT.95222866  DT.95247517 

    Selected AceView cDNA sequences (see all 372):

    AA677725 AI140426 AW516189 BU620178 BC003376 BQ945013 BQ954812 BU619726 
    AL045054 BU754443 AA995630 BG339113 BG231495 AA593572 AW316517 AL713686 
    AA812505 BM471895 F13501 AL045072 CB157706 CN483266 CD367328 BG674062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELAVL1 expression in normal human tissues (normalized intensities)      ELAVL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGCGCCC
    ELAVL1 Expression
    About this image


    ELAVL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Distal Tubule Cells Distal Tubule
             Metanephros
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Epithelial Cells
             Distal Tubule Cells Distal Tubule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    ELAVL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELAVL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.184492

    UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELAVL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elavl11 , 5 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) less5
    ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) less1
    91(n)1
    98.47(a)1
      8 (2.00 cM)5
    155681  NM_010485.31  NP_034615.21 
     42847825 
    chicken
    (Gallus gallus)
    Aves ELAVL11 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) less 86.3(n)
    98.47(a)
      395637  NM_204833.1  NP_990164.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.51772 Xenopus laevis ribonucleoprotein (elrA) mRNA, complete cds less 78.93(n)    U17596.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elavl12 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) less 79.54(n)   30736  AF184244.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fne3 RNA binding 58(a)
    (best of 5)
      11D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea exc-73 HUD 54(a)   II(9576218-9580987)   --


    ENSEMBL Gene Tree for ELAVL1 (if available)
    TreeFam Gene Tree for ELAVL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELAVL1 gene
    PABPC1L2  PABPC52  PABPC42  PABPC4L2  ELAVL42  RBMS12  ELAVL32  RBMS32  
    PABPC32  ELAVL22  RBMS22  PABPC12  
    14 SIMAP similar genes for ELAVL1 using alignment to 4 protein entries:     ELAV1_HUMAN (see all proteins):
    ELAVL2    ELAVL4    ELAVL3    HNRNPA1    SF3B4    RBMS1
    TIA1    PABPC1L2A    PABPC1L2B    SRSF9    PABPC1    PABPC4
    HNRNPD    TIAL1

    ELAVL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELAVL1 (see all 911)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81123791,2
    C--8023232(+) CACTCA/GGTGGG 1 -- ds50010--------
    rs104245431,2
    C,F,H--8023260(+) CTGGAG/AAAGAG 1 -- ds500110Minor allele frequency- A:0.10NS EA NA WA 1020
    rs1501125511,2
    C--8023282(+) TGGGAA/GCTGAA 1 -- ds50010--------
    rs1125968381,2
    F--8023320(+) CACCCG/AAACTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1402917481,2
    --8023335(+) TCCCCC/TCGTGG 1 -- ds50010--------
    rs1454111921,2
    --8023532(+) AACACA/GAACCT 1 -- ut310--------
    rs1171798511,2
    F--8023571(+) GACAAT/CTGAGT 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1915985011,2
    --8023685(+) AACAAC/TTGTTT 1 -- ut310--------
    rs1380437821,2
    --8023687(+) CAATTA/GTTTAA 1 -- ut310--------
    rs58269921,2
    C--8023942(+) GGATT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for ELAVL1 (8023457 - 8070543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ELAVL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv138435CNV Insertion16902084
    nsv910994CNV Loss21882294
    nsv833734CNV Loss17160897
    dgv3716n71CNV Loss21882294
    dgv3715n71CNV Loss21882294
    nsv833733CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603466    OMIM disorders: --

    Selected diseases for ELAVL1 (see all 55):    About MalaCards
    paraneoplastic neurologic disorders    alk-positive anaplastic large cell lymphoma    estrogen-receptor positive breast cancer    anoxia
    anaplastic large cell lymphoma    merkel cell carcinoma    mucoepidermoid carcinoma    pleomorphic adenoma
    keratoconus    noma    medulloblastoma    familial adenomatous polyposis
    laryngeal squamous cell carcinoma    breast cancer    encephalomyelitis    oral cancer
    laryngitis    malignant glioma    lateral sclerosis    ovarian cancer


    ELAVL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ELAVL1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    visual impairment 55.9 15 18705402 (1), 18463097 (1), 11018049 (1), 10859327 (1) (see all 13)
    tumors 37.1 84 15328200 (6), 16799479 (5), 15781626 (4), 18824170 (4) (see all 36)
    colorectal carcinoma 34.5 6 18094611 (2), 19707506 (2), 12944397 (1), 19009247 (1)
    cancer 30.8 37 20370918 (3), 19487279 (2), 18468781 (2), 19114552 (2) (see all 18)
    breast cancer 30 30 19875930 (4), 19777567 (3), 18056170 (3), 19010922 (3) (see all 13)
    colon cancer 25 9 16799479 (3), 14562043 (1), 15473260 (1), 19208339 (1) (see all 5)
    ovarian carcinoma 22.4 17 14729623 (5), 16126263 (3), 14633672 (2), 19281587 (2)
    adenocarcinoma gastric 21 4 16243808 (2), 18056170 (1)
    carcinoma renal cell 20.9 2 20219773 (1), 14517280 (1)
    necrosis 12.5 6 17599736 (2), 12237300 (1), 12874024 (1), 11602610 (1)

    Genetic Association Database (GAD): ELAVL1
    Human Genome Epidemiology (HuGE) Navigator: ELAVL1 (3 documents)

    Export disorders for ELAVL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELAVL1 gene, integrated from 10 sources (see all 406):
    (articles sorted by number of sources associating them with ELAVL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of HuR, a ubiquitously expressed Elav- like protein. (PubMed id 8626503)1, 2, 3 Ma W.-J.... Furneaux H.M. (J. Biol. Chem. 1996)
    2. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PubMed id 12237300)1, 2, 9 Li H.... Laird-Offringa I.A. (J. Biol. Chem. 2002)
    3. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen- activated protein kinase-activated protein kinase 2. (PubMed id 14517288)1, 2, 9 Tran H.... Nagamine Y. (Mol. Cell. Biol. 2003)
    4. Delineation of mRNA export pathways by the use of cell-permeable peptides. (PubMed id 11729309)1, 2, 9 Gallouzi I.-E. and Steitz J.A. (Science 2001)
    5. Localization of the human HuR gene to chromosome 19p13.2. (PubMed id 9003489)1, 3, 9 Ma W.J. and Furneaux H. (Hum. Genet. 1997)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2 Weidensdorfer D.... Huettelmaiery S. (RNA 2009)
    8. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D.... Hughes T.R. (Nat. Biotechnol. 2009)
    9. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (EMBO Rep. 2007)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1994 HGNC: 3312 AceView: ELAVL1 Ensembl:ENSG00000066044 euGenes: HUgn1994
    ECgene: ELAVL1 H-InvDB: ELAVL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELAVL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELAVL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELAVL1 gene:
    Search GeneIP for patents involving ELAVL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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