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Aliases for ELAVL1 Gene

Aliases for ELAVL1 Gene

  • ELAV Like RNA Binding Protein 1 2 3
  • HUR 3 4 6
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) 2 3
  • Hu Antigen R 2 3
  • Hu-Antigen R 3 4
  • Embryonic Lethal, Abnormal Vision, Drosophila, Homolog-Like 1 3
  • ELAV-Like Protein 1 3
  • Embryonic Lethal 2
  • Abnormal Vision 2
  • Homolog-Like 1 2
  • Drosophila 2
  • ELAV1 3
  • MelG 3
  • Hua 3

External Ids for ELAVL1 Gene

Previous HGNC Symbols for ELAVL1 Gene

  • HUR

Previous GeneCards Identifiers for ELAVL1 Gene

  • GC19M007986
  • GC19M008132
  • GC19M007933
  • GC19M007929
  • GC19M008023
  • GC19M007693

Summaries for ELAVL1 Gene

Entrez Gene Summary for ELAVL1 Gene

  • The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

GeneCards Summary for ELAVL1 Gene

ELAVL1 (ELAV Like RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with ELAVL1 include breast cancer. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include RNA binding and protein kinase binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for ELAVL1 Gene

  • RNA-binding protein that binds to the 3-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5-UUUU[AG]UUU-3 motif in vitro. With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.

Gene Wiki entry for ELAVL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL1 Gene

Genomics for ELAVL1 Gene

Regulatory Elements for ELAVL1 Gene

Transcription factor binding sites by QIAGEN in the ELAVL1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ELAVL1 Gene

Start:
7,958,573 bp from pter
End:
8,445,041 bp from pter
Size:
486,469 bases
Orientation:
Minus strand

Genomic View for ELAVL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELAVL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL1 Gene

Proteins for ELAVL1 Gene

  • Protein details for ELAVL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15717-ELAV1_HUMAN
    Recommended name:
    ELAV-like protein 1
    Protein Accession:
    Q15717
    Secondary Accessions:
    • B4DVB8
    • Q53XN6
    • Q9BTT1

    Protein attributes for ELAVL1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36092 Da
    Quaternary structure:
    • Interacts with ANP32A (By similarity). Interact with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with ANP32A, AGO1 and AGO2. Interacts with IGF2BP2 and IGF2BP3.

    Three dimensional structures from OCA and Proteopedia for ELAVL1 Gene

    Alternative splice isoforms for ELAVL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELAVL1 Gene

Proteomics data for ELAVL1 Gene at MOPED

Post-translational modifications for ELAVL1 Gene

  • Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
  • Phosphorylated by MAPKAPK2.
  • Ubiquitination at Lys50, Lys55, Lys72, Lys92, Lys104, Lys120, Lys191, Lys313, and Lys320
  • Modification sites at PhosphoSitePlus

Other Protein References for ELAVL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ELAVL1 (HuR)

No data available for DME Specific Peptides for ELAVL1 Gene

Domains for ELAVL1 Gene

Gene Families for ELAVL1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for ELAVL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15717

UniProtKB/Swiss-Prot:

ELAV1_HUMAN :
  • Q15717
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL1: view

Function for ELAVL1 Gene

Molecular function for ELAVL1 Gene

GENATLAS Biochemistry: Drosophila Elav-like 1 (embryonic,lethal,abnormal vision),HuR,widely expressed,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded
UniProtKB/Swiss-Prot Function: RNA-binding protein that binds to the 3-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5-UUUU[AG]UUU-3 motif in vitro. With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.

Gene Ontology (GO) - Molecular Function for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 19561594
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003729 mRNA binding TAS 10660597
genes like me logo Genes that share ontologies with ELAVL1: view
genes like me logo Genes that share phenotypes with ELAVL1: view

Animal Models for ELAVL1 Gene

MGI Knock Outs for ELAVL1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAVL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ELAVL1 Gene

Localization for ELAVL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELAVL1 Gene

Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELAVL1 Gene COMPARTMENTS Subcellular localization image for ELAVL1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14517288
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 14517288
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ELAVL1: view

Pathways for ELAVL1 Gene

genes like me logo Genes that share pathways with ELAVL1: view

Pathways by source for ELAVL1 Gene

1 Qiagen pathway for ELAVL1 Gene
1 Cell Signaling Technology pathway for ELAVL1 Gene

Gene Ontology (GO) - Biological Process for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development TAS 9003489
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
GO:0016071 mRNA metabolic process --
GO:0045727 positive regulation of translation IDA 21613615
genes like me logo Genes that share ontologies with ELAVL1: view

Compounds for ELAVL1 Gene

(19) Novoseek inferred chemical compound relationships for ELAVL1 Gene

Compound -log(P) Hits PubMed IDs
leptomycin b 68.7 6
adenine 44.6 8
vegf 40.9 23
adenylate 31.3 6
uridine 22.8 3
genes like me logo Genes that share compounds with ELAVL1: view

Transcripts for ELAVL1 Gene

Unigene Clusters for ELAVL1 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAVL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL1 Gene

No ASD Table

Relevant External Links for ELAVL1 Gene

GeneLoc Exon Structure for
ELAVL1
ECgene alternative splicing isoforms for
ELAVL1

Expression for ELAVL1 Gene

mRNA expression in normal human tissues for ELAVL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELAVL1 Gene

SOURCE GeneReport for Unigene cluster for ELAVL1 Gene Hs.184492

mRNA Expression by UniProt/SwissProt for ELAVL1 Gene

Q15717-ELAV1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ELAVL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ELAVL1 Gene

Orthologs for ELAVL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELAVL1 35
  • 99.69 (n)
  • 100 (a)
ELAVL1 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELAVL1 35
  • 93.15 (n)
  • 99.39 (a)
ELAVL1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
ELAVL1 35
  • 93.25 (n)
  • 99.69 (a)
mouse
(Mus musculus)
Mammalia Elavl1 35
  • 91 (n)
  • 98.47 (a)
Elavl1 16
Elavl1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELAVL1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elavl1 35
  • 90.59 (n)
  • 98.47 (a)
chicken
(Gallus gallus)
Aves ELAVL1 35
  • 86.3 (n)
  • 98.47 (a)
ELAVL1 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5177 35
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl1 35
  • 79.24 (n)
  • 92.94 (a)
Str.2596 35
zebrafish
(Danio rerio)
Actinopterygii elavl1 35
elavl1 36
  • 81 (a)
OneToMany
hug 35
  • 74.53 (n)
  • 82.92 (a)
hug 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta elav 36
  • 37 (a)
ManyToMany
fne 36
  • 56 (a)
ManyToMany
Rbp9 36
  • 44 (a)
ManyToMany
EG:132E8.1 37
  • 46 (a)
fne 37
  • 58 (a)
Sxl 37
  • 44 (a)
elav 37
  • 52 (a)
CG5213 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea exc-7 36
  • 39 (a)
OneToMany
exc-7 37
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 36
  • 48 (a)
OneToMany
Species with no ortholog for ELAVL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL1 Gene

ENSEMBL:
Gene Tree for ELAVL1 (if available)
TreeFam:
Gene Tree for ELAVL1 (if available)

Paralogs for ELAVL1 Gene

Selected SIMAP similar genes for ELAVL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ELAVL1: view

Variants for ELAVL1 Gene

Sequence variations from dbSNP and Humsavar for ELAVL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10818 -- 7,962,433(+) AATCA(A/C)AGGTT utr-variant-3-prime, nc-transcript-variant
rs14394 -- 7,963,660(-) TTTGG(C/T)GCCGT synonymous-codon, reference, nc-transcript-variant
rs14610 -- 7,962,349(+) CAAAA(A/G)AAAAT utr-variant-3-prime, nc-transcript-variant
rs731604 -- 7,968,464(-) TCTGA(C/T)GGCAA intron-variant
rs745123 -- 7,968,647(-) TAGCC(A/G)GGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL1 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
dgv3716n71 CNV Loss 21882294
nsv833734 CNV Loss 17160897
nsv138435 CNV Insertion 16902084
nsv910994 CNV Loss 21882294

Relevant External Links for ELAVL1 Gene

HapMap Linkage Disequilibrium report
ELAVL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL1 Gene

Disorders for ELAVL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ELAVL1 Gene including...

Search for ELAVL1 Gene in MalaCards »

(26) Novoseek inferred disease relationships for ELAVL1 Gene

Disease -log(P) Hits PubMed IDs
visual impairment 55.9 13
tumors 37.1 66
colorectal carcinoma 34.5 6
cancer 30.8 24
breast cancer 30 26

Relevant External Links for ELAVL1

Genetic Association Database (GAD)
ELAVL1
Human Genome Epidemiology (HuGE) Navigator
ELAVL1
genes like me logo Genes that share disorders with ELAVL1: view

No data available for UniProtKB/Swiss-Prot for ELAVL1 Gene

Publications for ELAVL1 Gene

  1. Localization of the human HuR gene to chromosome 19p13.2. (PMID: 9003489) Ma W.J. … Furneaux H. (Hum. Genet. 1997) 2 3 23
  2. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PMID: 12237300) Li H. … Laird-Offringa I.A. (J. Biol. Chem. 2002) 3 4 23
  3. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen- activated protein kinase-activated protein kinase 2. (PMID: 14517288) Tran H. … Nagamine Y. (Mol. Cell. Biol. 2003) 3 4 23
  4. Cloning and characterization of HuR, a ubiquitously expressed Elav- like protein. (PMID: 8626503) Ma W.-J. … Furneaux H.M. (J. Biol. Chem. 1996) 2 3 4
  5. HuR knockdown changes the oncogenic potential of oral cancer cells. (PMID: 20332213) Kakuguchi W. … Higashino F. (Mol. Cancer Res. 2010) 3 23

Products for ELAVL1 Gene

  • antibodies-online proteins for ELAVL1
  • antibodies-online antibodies for ELAVL1
  • antibodies-online kits for ELAVL1

Sources for ELAVL1 Gene

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