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Aliases for ELAVL1 Gene

Aliases for ELAVL1 Gene

  • ELAV Like RNA Binding Protein 1 2 3 5
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) 2 3
  • Embryonic Lethal, Abnormal Vision, Drosophila, Homolog-Like 1 2 3
  • Hu Antigen R 2 3
  • Hu-Antigen R 3 4
  • HUR 3 4
  • ELAV-Like Protein 1 3
  • ELAV1 3
  • MelG 3
  • Hua 3

External Ids for ELAVL1 Gene

Previous HGNC Symbols for ELAVL1 Gene

  • HUR

Previous GeneCards Identifiers for ELAVL1 Gene

  • GC19M007986
  • GC19M008132
  • GC19M007933
  • GC19M007929
  • GC19M008023
  • GC19M007693

Summaries for ELAVL1 Gene

Entrez Gene Summary for ELAVL1 Gene

  • The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

GeneCards Summary for ELAVL1 Gene

ELAVL1 (ELAV Like RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with ELAVL1 include Hepatitis C Virus and Juvenile Astrocytoma. Among its related pathways are mRNA Splicing - Major Pathway and Toll Comparative Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ELAVL2.

UniProtKB/Swiss-Prot for ELAVL1 Gene

  • RNA-binding protein that binds to the 3-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5-UUUU[AG]UUU-3 motif in vitro (PubMed:8626503). With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).

Gene Wiki entry for ELAVL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL1 Gene

Genomics for ELAVL1 Gene

Regulatory Elements for ELAVL1 Gene

Enhancers for ELAVL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F007177 1.2 Ensembl ENCODE 59.2 +824.6 824585 7.1 HDGF PKNOX1 SIN3A FEZF1 ZNF121 ZNF302 CBX5 ZNF143 ZNF207 ZNF202 ELAVL1 XAB2 ZNF557 GTF2F1 ARHGEF18 INSR GC19P007151 GC19P007214
GH19F007521 1.5 FANTOM5 ENCODE 46.7 +482.8 482802 2.0 HDGF CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ELAVL1 HNRNPM ZNF414 XAB2 TIMM44 ZNF557 SNAPC2 PEX11G MCOLN1 GC19M007510
GH19F007390 1.5 FANTOM5 Ensembl ENCODE 42.7 +614.1 614066 2.0 ELF3 INSM2 ZNF76 KLF17 ARID4B RARA ZNF155 ZNF335 ZNF366 SMARCC2 ELAVL1 ZNF557 XAB2 GTF2F1 MIR6791 LRRC8E ARHGEF18 ENSG00000267852 ENSG00000268861
GH19F008388 1.4 Ensembl ENCODE 44.5 -387.2 -387186 10.3 HDGF PKNOX1 ARNT CREB3L1 MLX SIN3A ARID4B ZNF2 YY1 ZNF143 ZNF558 ZNF699 HNRNPM ELAVL1 XAB2 ZNF559 MARCH2 LINC01862 ENSG00000261866 LYPLA2P2
GH19F008239 1.4 Ensembl ENCODE 39.4 -235.4 -235390 3.3 HDGF PKNOX1 ARNT MLX SIN3A ARID4B ZNF2 YY1 CBX5 ZNF416 HNRNPM ELAVL1 ZNF558 XAB2 ZNF414 CERS4 ENSG00000271717 GC19P008268
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELAVL1 on UCSC Golden Path with GeneCards custom track

Promoters for ELAVL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001815805 59 2400 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5

Genomic Location for ELAVL1 Gene

Chromosome:
19
Start:
7,958,573 bp from pter
End:
8,005,659 bp from pter
Size:
47,087 bases
Orientation:
Minus strand

Genomic View for ELAVL1 Gene

Genes around ELAVL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL1 Gene

Proteins for ELAVL1 Gene

  • Protein details for ELAVL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15717-ELAV1_HUMAN
    Recommended name:
    ELAV-like protein 1
    Protein Accession:
    Q15717
    Secondary Accessions:
    • B4DVB8
    • Q53XN6
    • Q9BTT1

    Protein attributes for ELAVL1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36092 Da
    Quaternary structure:
    • Monomer and homodimer (in vitro) (PubMed:17632515, PubMed:20219472). Interacts with ANP32A (PubMed:11729309). Interacts with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1 (PubMed:19029303). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with IGF2BP2 and IGF2BP3 (PubMed:23640942). Interacts with HNRNPL (PubMed:18161049).

    Three dimensional structures from OCA and Proteopedia for ELAVL1 Gene

    Alternative splice isoforms for ELAVL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELAVL1 Gene

Post-translational modifications for ELAVL1 Gene

  • Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
  • Phosphorylated by MAPKAPK2 (PubMed:14517288). Phosphorylated by PRKCD (PubMed:18285462).
  • Ubiquitination at Lys 50, Lys 55, Lys 72, Lys 104, Lys 120, Lys 191, Lys 313, and Lys 320
  • Modification sites at PhosphoSitePlus

Other Protein References for ELAVL1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ELAVL1 (HuR)

No data available for DME Specific Peptides for ELAVL1 Gene

Domains & Families for ELAVL1 Gene

Gene Families for ELAVL1 Gene

Suggested Antigen Peptide Sequences for ELAVL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15717

UniProtKB/Swiss-Prot:

ELAV1_HUMAN :
  • The first RRM (RNA recognition motif) domain is essential for binding to AU-rich elements.
  • Belongs to the RRM elav family.
Domain:
  • The first RRM (RNA recognition motif) domain is essential for binding to AU-rich elements.
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL1: view

Function for ELAVL1 Gene

Molecular function for ELAVL1 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 1 (embryonic,lethal,abnormal vision),HuR,widely expressed,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded
UniProtKB/Swiss-Prot Function:
RNA-binding protein that binds to the 3-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5-UUUU[AG]UUU-3 motif in vitro (PubMed:8626503). With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).

Gene Ontology (GO) - Molecular Function for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 19561594
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003729 mRNA binding TAS 10660597
genes like me logo Genes that share ontologies with ELAVL1: view
genes like me logo Genes that share phenotypes with ELAVL1: view

Animal Models for ELAVL1 Gene

MGI Knock Outs for ELAVL1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL1 Gene

Localization for ELAVL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELAVL1 Gene

Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462). {ECO:0000269 PubMed:14517288, ECO:0000269 PubMed:18285462}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELAVL1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 14517288
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 14517288
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ELAVL1: view

Pathways & Interactions for ELAVL1 Gene

genes like me logo Genes that share pathways with ELAVL1: view

Pathways by source for ELAVL1 Gene

1 Cell Signaling Technology pathway for ELAVL1 Gene
1 BioSystems pathway for ELAVL1 Gene
1 KEGG pathway for ELAVL1 Gene
1 Qiagen pathway for ELAVL1 Gene

SIGNOR curated interactions for ELAVL1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0007275 multicellular organism development TAS 9003489
GO:0043488 regulation of mRNA stability TAS --
GO:0045727 positive regulation of translation IDA 21613615
GO:0048255 mRNA stabilization IMP,IDA 19029303
genes like me logo Genes that share ontologies with ELAVL1: view

Drugs & Compounds for ELAVL1 Gene

(12) Drugs for ELAVL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for ELAVL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELAVL1: view

Transcripts for ELAVL1 Gene

Unigene Clusters for ELAVL1 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL1 Gene

No ASD Table

Relevant External Links for ELAVL1 Gene

GeneLoc Exon Structure for
ELAVL1
ECgene alternative splicing isoforms for
ELAVL1

Expression for ELAVL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ELAVL1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ELAVL1 Gene



Protein tissue co-expression partners for ELAVL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELAVL1 Gene:

ELAVL1

SOURCE GeneReport for Unigene cluster for ELAVL1 Gene:

Hs.184492

mRNA Expression by UniProt/SwissProt for ELAVL1 Gene:

Q15717-ELAV1_HUMAN
Tissue specificity: Ubiquitous. Detected in brain, liver, thymus and muscle.
genes like me logo Genes that share expression patterns with ELAVL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ELAVL1 Gene

Orthologs for ELAVL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELAVL1 35 34
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
ELAVL1 34
  • 93.25 (n)
-- 35
  • 66 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ELAVL1 34 35
  • 93.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL1 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elavl1 16 35 34
  • 91 (n)
rat
(Rattus norvegicus)
Mammalia Elavl1 34
  • 90.59 (n)
oppossum
(Monodelphis domestica)
Mammalia ELAVL1 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELAVL1 34 35
  • 86.3 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl1 34
  • 79.24 (n)
Str.2596 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5177 34
zebrafish
(Danio rerio)
Actinopterygii elavl1 34 35
  • 81 (a)
hug 34 35
  • 74.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta fne 36 35
  • 58 (a)
elav 36 35
  • 52 (a)
EG:132E8.1 36
  • 46 (a)
Sxl 36
  • 44 (a)
Rbp9 35
  • 44 (a)
ManyToMany
CG5213 36
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea exc-7 36 35
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 35
  • 48 (a)
OneToMany
Species where no ortholog for ELAVL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL1 Gene

ENSEMBL:
Gene Tree for ELAVL1 (if available)
TreeFam:
Gene Tree for ELAVL1 (if available)

Paralogs for ELAVL1 Gene

(14) SIMAP similar genes for ELAVL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ELAVL1: view

Variants for ELAVL1 Gene

Sequence variations from dbSNP and Humsavar for ELAVL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401186 -- 7,976,499(+) gtgaa(A/G)atgga intron-variant
rs10402424 -- 7,977,093(+) TGAAC(A/G)GCAGG intron-variant
rs10402477 -- 7,961,562(+) TGTGT(C/T)GAATC nc-transcript-variant, utr-variant-3-prime
rs10407901 -- 7,974,842(+) ATCTG(C/T)GTGCT intron-variant
rs10416815 -- 7,984,968(+) agggt(C/G)tcagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL1 Gene

Variant ID Type Subtype PubMed ID
nsv953963 CNV deletion 24416366
nsv833734 CNV loss 17160897
nsv833733 CNV gain 17160897
nsv472991 CNV novel sequence insertion 20440878
nsv138435 CNV insertion 16902084
nsv1071903 CNV deletion 25765185
dgv1705n106 CNV deletion 24896259

Variation tolerance for ELAVL1 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELAVL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELAVL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL1 Gene

Disorders for ELAVL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ELAVL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
juvenile astrocytoma
  • pediatric astrocytoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ELAVL1

Genetic Association Database (GAD)
ELAVL1
Human Genome Epidemiology (HuGE) Navigator
ELAVL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELAVL1
genes like me logo Genes that share disorders with ELAVL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL1 Gene

Publications for ELAVL1 Gene

  1. The x-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism. (PMID: 20219472) Benoit R.M. … Auer M. (J. Mol. Biol. 2010) 3 4 22 64
  2. Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. (PMID: 18285462) Doller A. … Eberhardt W. (Mol. Cell. Biol. 2008) 3 4 22 64
  3. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen- activated protein kinase-activated protein kinase 2. (PMID: 14517288) Tran H. … Nagamine Y. (Mol. Cell. Biol. 2003) 3 4 22 64
  4. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PMID: 12237300) Li H. … Laird-Offringa I.A. (J. Biol. Chem. 2002) 3 4 22 64
  5. Cloning and characterization of HuR, a ubiquitously expressed Elav- like protein. (PMID: 8626503) Ma W.-J. … Furneaux H.M. (J. Biol. Chem. 1996) 2 3 4 64

Products for ELAVL1 Gene

Sources for ELAVL1 Gene

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