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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ELAVL1 Gene

protein-coding   GIFtS: 61
GCID: GC19M008023

ELAV (embryonic lethal, abnormal vision, Drosophila)-like...


(Previous symbol: HUR)
 Explore 57 diseases affiliated with
ELAVL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ELAVL1    

Aliases
for ELAVL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen
R)1 2
     Hu-Antigen R2 3
HUR1 2 3 5     ELAV12
Hua1 2     ELAV-Like Protein 12
MelG1 2     Embryonic Lethal, Abnormal Vision, Drosophila, Homolog-Like 12
HuR1 3     Hu Antigen R2

External Ids:    HGNC: 33121   Entrez Gene: 19942   Ensembl: ENSG000000660447   OMIM: 6034665   UniProtKB: Q157173   

Export aliases for ELAVL1 gene to outside databases

Previous GC identifers: GC19M007986 GC19M008132 GC19M007933 GC19M007929 GC19M007693


Summaries
for ELAVL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ELAVL1:
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA
recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs
signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins
play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes
and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be
potentially useful in cancer diagnosis, prognosis, and therapy. (provided by RefSeq, Sep 2012)

UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717
Function: Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and
IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that
contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro

Gene Wiki entry for ELAVL1


Genomic Views
for ELAVL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_077812.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ELAVL1 gene promoter:
         AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ELAVL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELAVL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ELAVL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELAVL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M008023:  view genomic region     (about GC identifiers)

Start:
 8,023,457 bp from pter      End:
 8,070,529 bp from pter
Size:
 47,073 bases      Orientation:
 minus strand

Proteins
for ELAVL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717 (See protein sequence)
Recommended Name: ELAV-like protein 1  
Size: 326 amino acids; 36092 Da
Subunit: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2,
PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with ANP32A, EIF2C1 and EIF2C2
Subcellular location: Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2
4 PDB 3D structures from and Proteopedia for ELAVL1:
3HI9 (3D)        4ED5 (3D)        4EGL (3D)        4FXV (3D)    
Secondary accessions: Q53XN6 Q9BTT1

Explore the universe of human proteins at neXtProt for ELAVL1: NX_Q15717

Post-translational modifications:

  • Phosphorylated by MAPKAPK21
  • Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15717

    • ELAVL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001410.2  
    ENSEMBL proteins: 
     ENSP00000264073   ENSP00000385269  
    Reactome Protein details: Q15717
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ELAVL1
    OriGene Protein Over-expression Lysate: ELAVL1
    OriGene Custom Protein Services for ELAVL1 
    GenScript Custom Purified and Recombinant Proteins Services for ELAVL1
    Novus Biologicals ELAVL1 Proteins
    Novus Biologicals ELAVL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ELAVL1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14517288
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA14517288
    GO:0005829cytosol TAS--


    ELAVL1 for ontologies           About GeneDecksing



    ELAVL1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ELAVL1
    Browse R&D Systems for Antibodies
    OriGene Antibodies: ELAVL1
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    Novus Biologicals ELAVL1 Antibodies
    Abcam antibodies for ELAVL1 
    Uscn Antibodies for ELAVL1
    ThermoFisher Antibodies for ELAVL1

    Assay Products for ELAVL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELAVL1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ELAVL1

    Protein Domains /
    Families
    for ELAVL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ELAVL1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000504 RRM_dom
     IPR006548 ELAD_HUD_SF
     IPR002343 Hud_Sxl_RNA
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q15717

    ProtoNet protein and cluster: Q15717

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002343 Paraneoplastic encephalomyelitis antigen family signature


    UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717
    Similarity: Belongs to the RRM elav family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Function
    for ELAVL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717
    Function: Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and
    IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that
    contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro

         Genatlas biochemistry entry for ELAVL1:
    Drosophila Elav-like 1 (embryonic,lethal,abnormal vision),HuR,widely expressed,shuttling the ERG class of mRNA to the
    cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded

    miRNA
    Products:            		miRTarBase miRNAs that target ELAVL1:
    hsa-mir-125a-5p (MIRT005421), hsa-mir-519c-3p (MIRT003732), hsa-mir-519b-3p (MIRT003731), hsa-mir-519a (MIRT003733)

    OriGene 3'-UTR Clone: ELAVL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELAVL1
    8/127 QIAGEN miScript miRNA Assays for microRNAs that regulate ELAVL1 (see all 127):
    hsa-miR-124* hsa-miR-579 hsa-miR-548j hsa-miR-582-3p hsa-miR-26a-2* hsa-miR-3152-3p hsa-miR-607 hsa-miR-300
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELAVL1 (see all 7)
    OriGene shRNA RFP: ELAVL1
    OriGene siRNA: ELAVL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELAVL1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ELAVL1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELAVL1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELAVL1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ELAVL1 (NM_001419)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELAVL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELAVL1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ELAVL1
    Search LifeMap BioReagents cell lines for ELAVL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELAVL1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IDA--
    GO:0003729mRNA binding TAS10660597
    GO:0005515protein binding IPI17932509
    GO:0017091AU-rich element binding IDA14517288


    ELAVL1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ELAVL1:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for ELAVL1: Elavl1tm1.1Thla Elavl1tm1.2Dkon
         15/17 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Elavl1) (see all 17):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  normal  reproductive system  respiratory system 

    ELAVL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ELAVL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Stabilization of mRNA by HuR
    		Stabilization of mRNA by HuR1.00
    		Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm0.75
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Selected targets of CREB1
    		Selected targets of CREB11.00
    4AMPK signaling
    		AMPK signaling1.00
    5Ubiquitinated Orc1 is degraded by the proteasome
    		Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.55

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ELAVL1
        Selected targets of CREB1

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ELAVL1
        iNOS Signaling

    1 BioSystems Pathway for ELAVL1 
        AMPK signaling

    5/6        Reactome Pathways for ELAVL1 (see all 6)
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Metabolism of RNA
    Metabolism of mRNA
    Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm
    Gene Expression



    ELAVL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ELAVL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/2387 Interacting proteins for ELAVL1 (Q157172, 3 ENSP000003852694) via UniProtKB, MINT, STRING, and/or I2D (see all 2387)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5206079 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    KPNA1P522942, 3, ENSP000003437014MINT-7945693 I2D: score=1 STRING: ENSP00000343701
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    SREK1Q8WXA92, 3, ENSP000003345384MINT-7947479 I2D: score=1 STRING: ENSP00000334538
    TNPO1Q929732, 3, ENSP000003367124MINT-7947479 I2D: score=1 STRING: ENSP00000336712
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS9003489
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--
    GO:0045727positive regulation of translation IDA--


    ELAVL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ELAVL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ELAVL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ELAVL1
    10/19 Novoseek chemical compound relationships for ELAVL1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 68.7 10 14633672 (1), 11018049 (1), 11565755 (1), 18202756 (1) (see all 6)
    adenine 44.6 9 16289864 (2), 11280780 (2), 14729623 (1), 16788138 (1) (see all 6)
    vegf 40.9 30 9497373 (5), 16306087 (3), 15707649 (3), 16170373 (2) (see all 12)
    adenylate 31.3 8 16714065 (2), 17127772 (1), 10859327 (1), 17581403 (1) (see all 5)
    uridine 22.8 4 11280780 (2), 16890199 (1)
    prostaglandin 4.86 1 19208339 (1)
    dihydrotestosterone 2.18 8 11356683 (3), 15325278 (1)
    glucose 1.8 1 11741601 (1)
    infliximab 1.55 3 17599736 (3)
    atp 0 22 16788138 (4), 17392515 (3), 14523003 (1), 17466948 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about ELAVL1 / ELAV1 

    Transcripts
    for ELAVL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ELAVL1 gene: 
    NM_001419.2  

    Unigene Cluster for ELAVL1:

    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
    Hs.184492  [show with all ESTs]
    Unigene Representative Sequence: NM_001419
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351593 ENST00000407627(uc002mjb.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ELAVL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELAVL1
    8/127 QIAGEN miScript miRNA Assays for microRNAs that regulate ELAVL1 (see all 127):
    hsa-miR-124* hsa-miR-579 hsa-miR-548j hsa-miR-582-3p hsa-miR-26a-2* hsa-miR-3152-3p hsa-miR-607 hsa-miR-300
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELAVL1 (see all 7)
    OriGene shRNA RFP: ELAVL1
    OriGene siRNA: ELAVL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELAVL1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELAVL1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELAVL1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ELAVL1 (NM_001419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELAVL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELAVL1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELAVL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELAVL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELAVL1

    Additional cDNA sequence: 

    AK096659.1 AK301013.1 AL713686.1 BC003376.2 BT009793.1 BX647856.1 U38175.1 

    10 DOTS entries:

    DT.318483  DT.100818939  DT.95127039  DT.95274284  DT.121485795  DT.430165  DT.121485798  DT.91850162 
    DT.95222866  DT.95247517 

    24/372 AceView cDNA sequences (see all 372):

    BQ946768 BG739950 BE296753 BG939333 CD678096 AA677725 BU619726 AA322971 
    AW612662 BM554851 Z42016 AW069128 AA341426 AI140426 AI378336 AI669986 
    AL045054 BG116700 AL045141 AA912172 AA876724 AA812505 BM979090 F13501 

    GeneLoc Exon Structure


    Expression
    for ELAVL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ELAVL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACAGCGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ELAVL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyDistal TubuleDistal Tubule CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyDistal TubuleKidney
    KidneyEpithelial TubuleKidney
    KidneyInterstitial StromaKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ELAVL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ELAVL1

    SOURCE GeneReport for Unigene cluster: Hs.184492

    UniProtKB/Swiss-Prot: ELAV1_HUMAN, Q15717
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for ELAVL1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ELAVL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELAVL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELAVL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELAVL1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELAVL1

    Orthologs
    for ELAVL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ELAVL1 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ELAVL11 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 86.3(n)
    98.47(a)    		   395637  NM_204833.1  NP_990164.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.51772 Xenopus laevis ribonucleoprotein (elrA) mRNA, complete more 78.93(n)    U17596.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii elavl12 ELAV (embryonic lethal, abnormal vision, Drosophila)-like more 79.54(n)   30736  AF184244.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fne3 RNA binding 58(a)
    (best of 5)    		   11D4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea exc-71 , 3 HUD3
    Protein EXC-71    		 54(a)3
    57.1(n)1
    61.72(a)1    		   II(9576218-9580987)3
    1745061  NM_063656.31  NP_496057.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons FCA6
    AT2G473106
    		 flowering time control protein-like protein
    		 8(a)
    11(a)
    		 many ↔ many
    many ↔ many
    		 4(9206597-9214825)
    2(19423684-19427277)
    rice
    (Oryza sativa)    		 Liliopsida FCA6
    		 flowering time control protein FCA, putative, expr...
    		 8(a)
    		 1 → many
    		 9(1789446-1798611)


    ENSEMBL Gene Tree for ELAVL1 (if available)
    TreeFam Gene Tree for ELAVL1 (if available) 

    Paralogs
    for ELAVL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ELAVL1 gene
    PABPC1L2  PABPC52  PABPC42  PABPC4L2  RBMS12  ELAVL42  RBMS32  ELAVL32  
    PABPC32  PABPC1L2B2  ELAVL22  PABPC1L2A2  PUF602  RBMS22  PABPC12  
    11 SIMAP similar genes for ELAVL1 using alignment to 4 protein entries:     ELAV1_HUMAN (see all proteins):
    ELAVL2    ELAVL4    ELAVL3    HNRNPA1    SF3B4    RBMS1
    PABPC1L2A    PABPC1L2B    PABPC4    SRSF9    TIAL1

    ELAVL1 for paralogs           About GeneDecksing



    Genomic Variants
    for ELAVL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/752 NCBI SNPs in ELAVL1 are shown (see all 752)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs785484501,2
    		F,--7696382(+) GAGTTT/CCAGAA 1 -- ut311Minor allele frequency- C:0.03EA 120
    rs81123791,2
    		C,--8023232(+) CACTCA/GGTGGG 1 -- ds50010--------
    rs104245431,2
    		C,F,H,--8023260(+) CTGGAG/AAAGAG 1 -- ds500110Minor allele frequency- A:0.10NS EA NA WA 1020
    rs1501125511,2
    		--8023282(+) TGGGAA/GCTGAA 1 -- ds50010--------
    rs1125968381,2
    		--8023320(+) CACCCG/AAACTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1402917481,2
    		--8023335(+) TCCCCC/TCGTGG 1 -- ds50010--------
    rs752785011,2
    		C,--8023388(+) CCCAT-/CCCCTG 1 -- ds50010--------
    rs58269911,2
    		C--8023389(+) ATCCCC/-TGGCA 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1454111921,2
    		--8023532(+) AACACA/GAACCT 1 -- ut310--------
    rs1171798511,2
    		--8023571(+) GACAAT/CTGAGT 1 -- ut311Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for ELAVL1 (8023457 - 8070529 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ELAVL1
         1 CNV: 5078

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ELAVL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ELAVL1 for disorders           About GeneDecksing

    OMIM gene information: 603466    OMIM disorders: --

    20/57 diseases for ELAVL1 (see all 57):    About MalaCards
    estrogen-receptor positive breast cancer    anaplastic large cell lymphoma    paraneoplastic neurologic disorders    familial adenomatous polyposis
    amyotrophic lateral sclerosis    b-cell lymphomas    laryngeal squamous cell carcinoma    lateral sclerosis
    merkel cell carcinoma    squamous cell carcinoma    breast cancer susceptibility    pleomorphic adenoma
    rheumatoid arthritis    breast cancer    carcinoma    mucoepidermoid carcinoma
    myeloid leukemia    malignant glioma    renal cell carcinoma    anoxia

    10/26 Novoseek disease relationships for ELAVL1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    visual impairment 55.9 15 18705402 (1), 18463097 (1), 11018049 (1), 10859327 (1) (see all 13)
    tumors 37.1 84 15328200 (6), 16799479 (5), 15781626 (4), 18824170 (4) (see all 36)
    colorectal carcinoma 34.5 6 18094611 (2), 19707506 (2), 12944397 (1), 19009247 (1)
    cancer 30.8 37 20370918 (3), 19487279 (2), 18468781 (2), 19114552 (2) (see all 18)
    breast cancer 30 30 19875930 (4), 19777567 (3), 18056170 (3), 19010922 (3) (see all 13)
    colon cancer 25 9 16799479 (3), 14562043 (1), 15473260 (1), 19208339 (1) (see all 5)
    ovarian carcinoma 22.4 17 14729623 (5), 16126263 (3), 14633672 (2), 19281587 (2)
    adenocarcinoma gastric 21 4 16243808 (2), 18056170 (1)
    carcinoma renal cell 20.9 2 20219773 (1), 14517280 (1)
    necrosis 12.5 6 17599736 (2), 12237300 (1), 12874024 (1), 11602610 (1)

    Human Genome Epidemiology (HuGE) Navigator: ELAVL1 (3 documents)

    Export disorders for ELAVL1 gene to outside databases

    Publications
    for ELAVL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ELAVL1 gene, integrated from 9 sources (see all 368):
    (articles sorted by number of sources associating them with ELAVL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of HuR, a ubiquitously expressed Elav- like protein. (PubMed id 8626503)1, 2, 3 Ma W.-J.... Furneaux H.M. (1996)
    2. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PubMed id 12237300)1, 2, 9 Li H.... Laird-Offringa I.A. (2002)
    3. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. (PubMed id 14517288)1, 2, 9 Tran H....Nagamine Y. (2003)
    4. Delineation of mRNA export pathways by the use of cell-permeable peptides. (PubMed id 11729309)1, 2, 9 Gallouzi I.-E. and Steitz J.A. (2001)
    5. Localization of the human HuR gene to chromosome 19p13.2. (PubMed id 9003489)1, 3, 9 Ma W.J. and Furneaux H. (1997)
    6. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2 Weidensdorfer D....HA1ttelmaier S. (2009)
    7. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D....Hughes T.R. (2009)
    8. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (2007)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for ELAVL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ELAVL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1994 HGNC: 3312 AceView: ELAVL1 Ensembl:ENSG00000066044 euGenes: HUgn1994
    ECgene: ELAVL1 H-InvDB: ELAVL1

    Other Databases showing ELAVL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ELAVL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ELAVL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ELAVL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ELAVL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ELAVL1 gene:
    Search GeneIP for patents involving ELAVL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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