Aliases for ELAC2 Gene
External Ids for ELAC2 Gene
Previous GeneCards Identifiers for ELAC2 Gene
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for ELAC2 Gene
ELAC2 (ElaC Ribonuclease Z 2) is a Protein Coding gene. Diseases associated with ELAC2 include prostate cancer, hereditary, 2 and combined oxidative phosphorylation deficiency 17. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include poly(A) RNA binding and 3-tRNA processing endoribonuclease activity.
UniProtKB/Swiss-Prot for ELAC2 Gene
Zinc phosphodiesterase, which displays mitochondrial tRNA 3-processing endonuclease activity. Involved in tRNA maturation, by removing a 3-trailer from precursor tRNA.