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Aliases for ELAC1 Gene

Aliases for ELAC1 Gene

  • ElaC Ribonuclease Z 1 2 3 5
  • ElaC Homolog Protein 1 3 4
  • TRNA 3 Endonuclease 1 3 4
  • TRNA Z (Short Form) 2 3
  • Ribonuclease Z 1 3 4
  • Deleted In Ma29 3 4
  • EC 3.1.26.11 4 61
  • TRNase Z 1 3 4
  • RNaseZ(S) 2 3
  • RNase Z 1 3 4
  • D29 3 4
  • Zinc Phosphodiesterase ELAC Protein 1 3
  • TRNA 3 Processing Endoribonuclease 3
  • ElaC (E. Coli) Homolog 1 2
  • ElaC Homolog 1 (E. Coli) 2
  • ElaC Homolog 1 3
  • TRNase ZS 3

External Ids for ELAC1 Gene

Previous GeneCards Identifiers for ELAC1 Gene

  • GC18P048678
  • GC18P048429
  • GC18P046746
  • GC18P046748
  • GC18P045349
  • GC18P048496

Summaries for ELAC1 Gene

GeneCards Summary for ELAC1 Gene

ELAC1 (ElaC Ribonuclease Z 1) is a Protein Coding gene. Diseases associated with ELAC1 include Prostate Cancer Susceptibility. Among its related pathways are RNA transport. GO annotations related to this gene include endoribonuclease activity, producing 5-phosphomonoesters and 3-tRNA processing endoribonuclease activity. An important paralog of this gene is ENSG00000267699.

UniProtKB/Swiss-Prot for ELAC1 Gene

  • Zinc phosphodiesterase, which displays some tRNA 3-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3-trailer from precursor tRNA.

Gene Wiki entry for ELAC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAC1 Gene

Genomics for ELAC1 Gene

Regulatory Elements for ELAC1 Gene

Enhancers for ELAC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G051189 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +226.6 226570 9.4 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF416 ZNF263 SP3 NFYC SMAD4 MEX3C ELAC1 LOC105372118 PIR40243
GH18G050283 1.4 ENCODE dbSUPER 13.7 -681.8 -681836 5.0 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 SMAD4 RPL17 ELAC1 DYM CXXC1 CFAP53 MBD1
GH18G050628 1 dbSUPER 13.7 -339.2 -339216 3.5 FOXA2 ARID4B FEZF1 ZNF2 YY1 SLC30A9 ZNF263 SP3 SP5 REST ELAC1 PIR50564 GC18M050544
GH18G050629 1 dbSUPER 13.7 -339.2 -339235 3.2 FOXA2 ARID4B FEZF1 ZNF2 YY1 SLC30A9 ZNF263 SP3 SP5 REST ELAC1 PIR50564 GC18M050544
GH18G050724 0.7 ENCODE 12.7 -241.4 -241431 4.4 PKNOX1 FOXA2 CREB3L1 POLR2A EED ZNF26 SCRT2 IKZF2 CREM SCRT1 ELAC1 MAPK4 LOC105372116 ENSG00000267713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELAC1 on UCSC Golden Path with GeneCards custom track

Promoters for ELAC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103337 409 1601 CREB3L1 WRNIP1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 REST

Genomic Location for ELAC1 Gene

Chromosome:
18
Start:
50,967,991 bp from pter
End:
50,988,121 bp from pter
Size:
20,131 bases
Orientation:
Plus strand

Genomic View for ELAC1 Gene

Genes around ELAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAC1 Gene

Proteins for ELAC1 Gene

  • Protein details for ELAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H777-RNZ1_HUMAN
    Recommended name:
    Zinc phosphodiesterase ELAC protein 1
    Protein Accession:
    Q9H777
    Secondary Accessions:
    • Q9NS99

    Protein attributes for ELAC1 Gene

    Size:
    363 amino acids
    Molecular mass:
    40019 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for ELAC1 Gene

neXtProt entry for ELAC1 Gene

Selected DME Specific Peptides for ELAC1 Gene

Q9H777:
  • WLFDCGE
  • DCGEGTQ
  • FGLPGLL
  • LLIHEAT

Post-translational modifications for ELAC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ELAC1 Gene

Protein Domains for ELAC1 Gene

Suggested Antigen Peptide Sequences for ELAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H777

UniProtKB/Swiss-Prot:

RNZ1_HUMAN :
  • Belongs to the RNase Z family.
Family:
  • Belongs to the RNase Z family.
genes like me logo Genes that share domains with ELAC1: view

No data available for Gene Families for ELAC1 Gene

Function for ELAC1 Gene

Molecular function for ELAC1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing extra 3 nucleotides from tRNA precursor, generating 3 termini of tRNAs. A 3-hydroxy group is left at the tRNA terminus and a 5-phosphoryl group is left at the trailer molecule.
UniProtKB/Swiss-Prot Function:
Zinc phosphodiesterase, which displays some tRNA 3-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3-trailer from precursor tRNA.

Enzyme Numbers (IUBMB) for ELAC1 Gene

Gene Ontology (GO) - Molecular Function for ELAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016891 endoribonuclease activity, producing 5-phosphomonoesters IEA --
GO:0042781 3-tRNA processing endoribonuclease activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ELAC1: view
genes like me logo Genes that share phenotypes with ELAC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ELAC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ELAC1 Gene

Localization for ELAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELAC1 Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELAC1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ELAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21593607
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 21593607
genes like me logo Genes that share ontologies with ELAC1: view

Pathways & Interactions for ELAC1 Gene

SuperPathways for ELAC1 Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with ELAC1: view

Pathways by source for ELAC1 Gene

1 KEGG pathway for ELAC1 Gene

Interacting Proteins for ELAC1 Gene

Gene Ontology (GO) - Biological Process for ELAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0034414 tRNA 3-trailer cleavage, endonucleolytic IEA --
GO:0042779 tRNA 3-trailer cleavage IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with ELAC1: view

No data available for SIGNOR curated interactions for ELAC1 Gene

Transcripts for ELAC1 Gene

Unigene Clusters for ELAC1 Gene

ElaC homolog 1 (E. coli):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for ELAC1 Gene

GeneLoc Exon Structure for
ELAC1
ECgene alternative splicing isoforms for
ELAC1

Expression for ELAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELAC1 Gene

Protein differential expression in normal tissues from HIPED for ELAC1 Gene

This gene is overexpressed in Platelet (49.4), Ovary (8.6), and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ELAC1 Gene



Protein tissue co-expression partners for ELAC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ELAC1 Gene:

ELAC1

SOURCE GeneReport for Unigene cluster for ELAC1 Gene:

Hs.657360

mRNA Expression by UniProt/SwissProt for ELAC1 Gene:

Q9H777-RNZ1_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for ELAC1 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ELAC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELAC1 Gene

Orthologs for ELAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELAC1 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia ELAC1 34 35
  • 92.19 (n)
cow
(Bos Taurus)
Mammalia ELAC1 34 35
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Elac1 34 16
  • 86.65 (n)
rat
(Rattus norvegicus)
Mammalia Elac1 34
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia elac1 34
  • 67.03 (n)
Str.3800 34
zebrafish
(Danio rerio)
Actinopterygii elac1 34 35
  • 58.86 (n)
Dr.13263 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7442 34
Species where no ortholog for ELAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELAC1 Gene

ENSEMBL:
Gene Tree for ELAC1 (if available)
TreeFam:
Gene Tree for ELAC1 (if available)

Paralogs for ELAC1 Gene

Paralogs for ELAC1 Gene

genes like me logo Genes that share paralogs with ELAC1: view

Variants for ELAC1 Gene

Sequence variations from dbSNP and Humsavar for ELAC1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000197488 -- 50,978,762(+) TGAAT(C/G)TCTAG intron-variant, nc-transcript-variant
rs1000481110 -- 50,985,368(+) CAAAA(C/T)CCTGT intron-variant
rs1000833459 -- 50,966,706(+) GGAGG(A/C)CGAGG upstream-variant-2KB
rs1001154473 -- 50,972,625(+) CTACA(A/G)GTGTG intron-variant
rs1001211418 -- 50,979,824(+) CAGGT(G/T)GAAGT intron-variant

Variation tolerance for ELAC1 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ELAC1 Gene

Disorders for ELAC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ELAC1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer susceptibility
- elite association - COSMIC cancer census association via MalaCards
Search ELAC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ELAC1

Genetic Association Database (GAD)
ELAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELAC1
genes like me logo Genes that share disorders with ELAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAC1 Gene

Publications for ELAC1 Gene

  1. A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. (PMID: 12711671) Takaku H. … Nashimoto M. (Nucleic Acids Res. 2003) 2 3 4 22 64
  2. Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. (PMID: 11401430) Yanaihara N. … Yokota J. (Genomics 2001) 3 4 22 64
  3. Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation. (PMID: 21559454) Rossmanith W. (PLoS ONE 2011) 2 3 64
  4. Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs. (PMID: 21593607) Brzezniak L.K. … Stepien P.P. (RNA Biol 2011) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ELAC1 Gene

Sources for ELAC1 Gene

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