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Aliases for ELAC1 Gene

Aliases for ELAC1 Gene

  • ElaC Ribonuclease Z 1 2 3
  • ElaC Homolog Protein 1 3 4
  • TRNA 3 Endonuclease 1 3 4
  • TRNA Z (Short Form) 2 3
  • Ribonuclease Z 1 3 4
  • Deleted In Ma29 3 4
  • EC 3.1.26.11 4 63
  • TRNase Z 1 3 4
  • RNaseZ(S) 2 3
  • RNase Z 1 3 4
  • D29 3 4
  • TRNA 3 Processing Endoribonuclease 3
  • ElaC (E. Coli) Homolog 1 2
  • ElaC Homolog 1 (E. Coli) 2
  • ElaC Homolog 1 3
  • TRNase ZS 3

External Ids for ELAC1 Gene

Previous GeneCards Identifiers for ELAC1 Gene

  • GC18P048678
  • GC18P048429
  • GC18P046746
  • GC18P046748
  • GC18P045349
  • GC18P048496

Summaries for ELAC1 Gene

GeneCards Summary for ELAC1 Gene

ELAC1 (ElaC Ribonuclease Z 1) is a Protein Coding gene. Among its related pathways are RNA transport. GO annotations related to this gene include endoribonuclease activity, producing 5-phosphomonoesters and 3-tRNA processing endoribonuclease activity. An important paralog of this gene is ENSG00000267699.

UniProtKB/Swiss-Prot for ELAC1 Gene

  • Zinc phosphodiesterase, which displays some tRNA 3-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3-trailer from precursor tRNA

Gene Wiki entry for ELAC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAC1 Gene

Genomics for ELAC1 Gene

Regulatory Elements for ELAC1 Gene

Genomic Location for ELAC1 Gene

Chromosome:
18
Start:
50,967,991 bp from pter
End:
50,988,121 bp from pter
Size:
20,131 bases
Orientation:
Plus strand

Genomic View for ELAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAC1 Gene

Proteins for ELAC1 Gene

  • Protein details for ELAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H777-RNZ1_HUMAN
    Recommended name:
    Zinc phosphodiesterase ELAC protein 1
    Protein Accession:
    Q9H777
    Secondary Accessions:
    • Q9NS99

    Protein attributes for ELAC1 Gene

    Size:
    363 amino acids
    Molecular mass:
    40019 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions.;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for ELAC1 Gene

neXtProt entry for ELAC1 Gene

Proteomics data for ELAC1 Gene at MOPED

Selected DME Specific Peptides for ELAC1 Gene

Post-translational modifications for ELAC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ELAC1 Gene

Protein Domains for ELAC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H777

UniProtKB/Swiss-Prot:

RNZ1_HUMAN :
  • Belongs to the RNase Z family.
Family:
  • Belongs to the RNase Z family.
genes like me logo Genes that share domains with ELAC1: view

No data available for Gene Families for ELAC1 Gene

Function for ELAC1 Gene

Molecular function for ELAC1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing extra 3 nucleotides from tRNA precursor, generating 3 termini of tRNAs. A 3-hydroxy group is left at the tRNA terminus and a 5-phosphoryl group is left at the trailer molecule.
UniProtKB/Swiss-Prot Function:
Zinc phosphodiesterase, which displays some tRNA 3-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3-trailer from precursor tRNA

Enzyme Numbers (IUBMB) for ELAC1 Gene

Gene Ontology (GO) - Molecular Function for ELAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016891 endoribonuclease activity, producing 5-phosphomonoesters --
GO:0042781 3-tRNA processing endoribonuclease activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ELAC1: view

Phenotypes for ELAC1 Gene

genes like me logo Genes that share phenotypes with ELAC1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAC1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ELAC1 Gene

Localization for ELAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELAC1 Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELAC1 Gene COMPARTMENTS Subcellular localization image for ELAC1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ELAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21593607
GO:0005829 cytosol IDA 21593607
genes like me logo Genes that share ontologies with ELAC1: view

Pathways & Interactions for ELAC1 Gene

SuperPathways for ELAC1 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with ELAC1: view

Pathways by source for ELAC1 Gene

1 KEGG pathway for ELAC1 Gene

Interacting Proteins for ELAC1 Gene

Gene Ontology (GO) - Biological Process for ELAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034414 tRNA 3-trailer cleavage, endonucleolytic IBA --
GO:0042779 tRNA 3-trailer cleavage --
genes like me logo Genes that share ontologies with ELAC1: view

No data available for SIGNOR curated interactions for ELAC1 Gene

Drugs & Compounds for ELAC1 Gene

No Compound Related Data Available

Transcripts for ELAC1 Gene

Unigene Clusters for ELAC1 Gene

ElaC homolog 1 (E. coli):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for ELAC1 Gene

GeneLoc Exon Structure for
ELAC1
ECgene alternative splicing isoforms for
ELAC1

Expression for ELAC1 Gene

mRNA expression in normal human tissues for ELAC1 Gene

Protein differential expression in normal tissues from HIPED for ELAC1 Gene

This gene is overexpressed in Platelet (49.4), Ovary (8.6), and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ELAC1 Gene



SOURCE GeneReport for Unigene cluster for ELAC1 Gene Hs.657360

mRNA Expression by UniProt/SwissProt for ELAC1 Gene

Q9H777-RNZ1_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with ELAC1: view

Protein tissue co-expression partners for ELAC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ELAC1 Gene

Orthologs for ELAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELAC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELAC1 35
  • 91.92 (n)
  • 94.21 (a)
ELAC1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELAC1 35
  • 92.19 (n)
  • 94.77 (a)
ELAC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elac1 35
  • 86.65 (n)
  • 91.99 (a)
Elac1 16
chimpanzee
(Pan troglodytes)
Mammalia ELAC1 35
  • 99.45 (n)
  • 99.72 (a)
ELAC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elac1 35
  • 86.19 (n)
  • 92.54 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia elac1 35
  • 67.03 (n)
  • 70.17 (a)
Str.3800 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13263 35
elac1 35
  • 58.86 (n)
  • 58.13 (a)
elac1 36
  • 57 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7442 35
Species with no ortholog for ELAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELAC1 Gene

ENSEMBL:
Gene Tree for ELAC1 (if available)
TreeFam:
Gene Tree for ELAC1 (if available)

Paralogs for ELAC1 Gene

Paralogs for ELAC1 Gene

genes like me logo Genes that share paralogs with ELAC1: view

Variants for ELAC1 Gene

Sequence variations from dbSNP and Humsavar for ELAC1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs583276 -- 50,971,968(-) ATACT(G/T)GTGCA intron-variant
rs583677 -- 50,971,912(-) ATATA(C/T)ACACA intron-variant
rs590147 -- 50,985,214(+) TGTCT(C/T)CCCTT intron-variant
rs612329 -- 50,966,034(+) ATGCT(C/T)CTTAT upstream-variant-2KB
rs614884 -- 50,977,561(-) aaaaa(C/T)ggttt intron-variant

Variation tolerance for ELAC1 Gene

Residual Variation Intolerance Score: 40.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELAC1 Gene

HapMap Linkage Disequilibrium report
ELAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ELAC1 Gene

Disorders for ELAC1 Gene

Relevant External Links for ELAC1

Genetic Association Database (GAD)
ELAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELAC1
genes like me logo Genes that share disorders with ELAC1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELAC1 Gene

Publications for ELAC1 Gene

  1. A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. (PMID: 12711671) Takaku H. … Nashimoto M. (Nucleic Acids Res. 2003) 2 23 67
  2. Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation. (PMID: 21559454) Rossmanith W. (PLoS ONE 2011) 2 67
  3. Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. (PMID: 15892892) Chen Y. … Tavtigian S.V. (BMC Mol. Biol. 2005) 23 67
  4. Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. (PMID: 11401430) Yanaihara N. … Yokota J. (Genomics 2001) 23 67
  5. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 67

Products for ELAC1 Gene

Sources for ELAC1 Gene

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