Aliases for EIF6 Gene
External Ids for EIF6 Gene
Previous HGNC Symbols for EIF6 Gene
Previous GeneCards Identifiers for EIF6 Gene
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
GeneCards Summary for EIF6 Gene
EIF6 (Eukaryotic Translation Initiation Factor 6) is a Protein Coding gene. Diseases associated with EIF6 include shwachman-diamond syndrome and mucous membrane pemphigoid. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p70S6K Signaling. GO annotations related to this gene include translation initiation factor activity and ribosomal large subunit binding.
UniProtKB/Swiss-Prot for EIF6 Gene
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.