EIF5B Gene
protein-coding GIFtS: 54
GCID: GC02P099953
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eukaryotic translation initiation factor 5B
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Aliases for EIF5B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 5B1 2 | | EIF-5B1 | | IF21 2 3 | | DKFZp434I0361 | | KIAA07411 3 | | FLJ105241 | | Translation Initiation Factor IF-22 3 | | Translation Initiation Factor IF22 |
Export aliases for EIF5B gene to outside databasesPrevious GC identifers: GC02P099575 GC02P099412 GC02P099320 GC02P093719 |
Summaries for EIF5B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for EIF5B: Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed ofmultiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Twoof these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This geneencodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP toposition the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.(provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841Function: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA toribosomes. Seems to function along with eIF-2 (By similarity) Gene Wiki entry for EIF5B
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Genomic Views for EIF5B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the EIF5B gene promoter: Elk-1 NF-YA AREB6 NF-YB IRF-2 CBF-A CBF-B CP1A NF-Y CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF5B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF5B |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2EIF5B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P099953: view genomic region
(about GC identifiers)
Start:
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99,953,816 bp from pter |
End:
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100,016,728 bp from pter |
Size:
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62,913 bases |
Orientation:
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plus strand |
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Proteins for EIF5B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841 (See
protein sequence)Recommended Name: Eukaryotic translation initiation factor 5B Size: 1220 amino acids; 138827 Da
Subunit: Interacts with ANXA5 in a calcium and phospholipid-dependent manner (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA34461.2; Type=Erroneous initiation;
Secondary accessions: O95805 Q53RV7 Q53SI8 Q9UF81 Q9UMN7Explore the universe of human proteins at neXtProt for EIF5B: NX_O60841
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60841 EIF5B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056988.3 ENSEMBL proteins: ENSP00000289371 Reactome Protein details: O60841 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
EIF5B for ontologies About GeneDecksing
EIF5B Antibody Products: Assay Products for EIF5B: |
Protein
Domains / Families for EIF5B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF5B for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O60841ProtoNet protein and cluster: O60841 UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841Similarity: Belongs to the IF-2 family |
Function for EIF5B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841Function: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA toribosomes. Seems to function along with eIF-2 (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF5B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF5B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EIF5B (NM_015904) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF5B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF5B  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF5B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EIF5B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for EIF5B:
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Pathways & Interactions for EIF5B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Translation Factors | | | 3 | RNA transport | | | 4 | Generic Transcription Pathway | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
1 BioSystems Pathway for EIF5B 
5/6
Reactome Pathways for EIF5B (see all 6)
1
Kegg Pathway (Kegg details for EIF5B):
EIF5B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF5B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/837 Interacting proteins for EIF5B (O608411, 2, 3 ENSP000002893714) via UniProtKB, MINT, STRING, and/or I2D (see all 837)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
EIF5B for ontologies About GeneDecksing
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Drugs & Compounds for EIF5B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EIF5B for compounds About GeneDecksing
Browse Tocris compounds for EIF5B
1 HMDB Compound for EIF5B About this table 3 Novoseek chemical compound relationships for EIF5B gene About this table
Search CenterWatch for drugs/clinical trials and news about EIF5B / IF2P 
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Transcripts for EIF5B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for EIF5B gene: NM_015904.3 Unigene Cluster for EIF5B: Eukaryotic translation initiation factor 5B Hs.158688 [show with all ESTs]Unigene Representative Sequence: NM_0159044 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000289371(uc002tab.3 uc010yvq.2) ENST00000470868 ENST00000494190 ENST00000470023
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF5B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF5B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EIF5B (NM_015904) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF5B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF5B  |
Additional cDNA sequence: AB018284.1 AF078035.1 AJ006412.1 AJ006776.1 AK001386.1 AK091864.1 AK308175.1 AK308176.1 AL133563.1 BC006970.1 BC022260.1 BC032639.1 24/47 DOTS entries (see all 47): DT.115828 DT.95207194 DT.100037843 DT.91682701 DT.100827572 DT.91652870 DT.86999396 DT.97857766 DT.91765315 DT.120952507 DT.100827569 DT.95139591 DT.102843417 DT.100827565 DT.120952415 DT.87008566 DT.120952404 DT.75102490 DT.120952335 DT.120952392 DT.120952465 DT.120952551 DT.97770770 DT.100800390 24/556 AceView cDNA sequences (see all 556): AI053992 AA045302 AI867272 AI301442 BP341315 AI368900 BF594694 BG941697 AA180796 BF063994 AI190460 BG187857 CR613918 AI761747 F29452 BQ220870 F24780 CN485327 BI091981 AA954957 AI381943 BF514474 CB111477 BU677330 GeneLoc Exon Structure
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Expression for EIF5B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF5B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCCCCACAGT
About this image See EIF5B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for EIF5B
SOURCE GeneReport for Unigene cluster: Hs.158688 SABiosciences Expression via Pathway-Focused PCR Arrays including EIF5B:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF5B Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF5B | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF5B | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF5B | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF5B |
Orthologs for EIF5B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF5B gene from 10/41 species (see all 41) About this table
ENSEMBL Gene Tree for EIF5B (if available) TreeFam Gene Tree for EIF5B (if available)  |
Paralogs for EIF5B gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for EIF5B gene
- CYLC22 CYLC12
EIF5B for paralogs About GeneDecksing
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Genomic Variants for EIF5B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for EIF5B (99953816 - 100016728 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for EIF5B: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF5B |
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Disorders
/ Diseases for EIF5B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EIF5B for disorders About GeneDecksing
OMIM gene information: 606086
OMIM disorders: --
16 diseases for EIF5B: About MalaCardsvon hippel-lindau disease glucose intolerance acute promyelocytic leukemia germ cell tumor insulin resistance polycythemia vitiligo breast cancer myeloma obesity pneumonia leukemia tuberculosis hepatitis malaria mycobacterium tuberculosis
2 Novoseek disease relationships for EIF5B gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| virus infection |
0.383 |
2 |
7799945 (1), 14981762 (1) |
| tumors |
0 |
2 |
8863671 (2) |
Export disorders for EIF5B gene to outside databases
|
Publications for EIF5B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EIF5B gene, integrated from 9 sources (see all 96): (articles sorted by number of sources associating them with EIF5B) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2 and its interaction with HIV-1 matrix. (PubMed id 10432305)1, 2, 3 Wilson S.A....Martin-Rendon E. (1999)
- Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. (PubMed id 10200264)1, 2, 3 Lee J.H.... Dever T.E. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. (PubMed id 12569173)1, 9 Marintchev A....Wagner G. (2003)
- Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PubMed id 12514125)1, 9 Olsen D.S....Hinnebusch A.G. (2003)
- Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases. (PubMed id 18572216)1, 9 de Breyne S....Hellen C.U. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
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External Searches for EIF5B gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EIF5B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EIF5B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing EIF5B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for EIF5B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EIF5B gene: Search GeneIP for patents involving EIF5B
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for EIF5B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for EIF5B | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF5B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF5B | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for EIF5B | | OriGene 3'-UTR Clone for EIF5B | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF5B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF5B | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EIF5B | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF5B | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF5B | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF5B | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF5B | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF5B |
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 |  |  |  | |
| | | Search Tocris compounds for EIF5B |
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 | | EIF5B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF5B |
|  |  |  | | | Search ThermoFisher Antibodies for EIF5B |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF5B |
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