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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF5B Gene

protein-coding   GIFtS: 57
GCID: GC02P099953

Eukaryotic Translation Initiation Factor 5B

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 5B1 2
Translation Initiation Factor IF21 2
Translation Initiation Factor IF-22 3
IF22 3
eIF-5B2 3
KIAA07413

External Ids:    HGNC: 307931   Entrez Gene: 96692   Ensembl: ENSG000001584177   OMIM: 6060865   UniProtKB: O608413   

Export aliases for EIF5B gene to outside databases

Previous GC identifers: GC02P099575 GC02P099412 GC02P099320 GC02P093719


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EIF5B Gene:
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed
of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2,
IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is
eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation
factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation
initiates accurately. (provided by RefSeq, Jul 2008)

GeneCards Summary for EIF5B Gene: 
EIF5B (eukaryotic translation initiation factor 5B) is a protein-coding gene. Diseases associated with EIF5B include von hippel-lindau disease, and glucose intolerance, and among its related super-pathways are GTP hydrolysis and joining of the 60S ribosomal subunit and Generic Transcription Pathway. GO annotations related to this gene include GTP binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841
Function: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to
ribosomes. Seems to function along with eIF-2 (By similarity)

Gene Wiki entry for EIF5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF5B gene promoter:
         Elk-1   NF-YA   AREB6   NF-YB   IRF-2   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF5B promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

EIF5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF5B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P099953:  view genomic region     (about GC identifiers)

Start:
99,953,816 bp from pter      End:
100,016,728 bp from pter
Size:
62,913 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 5B  
Size: 1220 amino acids; 138827 Da
Subunit: Interacts with ANXA5 in a calcium and phospholipid-dependent manner (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA34461.2; Type=Erroneous initiation;
Secondary accessions: O95805 Q53RV7 Q53SI8 Q9UF81 Q9UMN7

Explore the universe of human proteins at neXtProt for EIF5B: NX_O60841

Explore proteomics data for EIF5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60841

  • EIF5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF5B Protein Expression
    REFSEQ proteins: NP_056988.3  
    ENSEMBL proteins: 
     ENSP00000289371  
    Reactome Protein details: O60841
    Human Recombinant Protein Products for EIF5B: 
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    Cloud-Clone Corp. Proteins for EIF5B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    EIF5B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR027417 P-loop_NTPase
     IPR000795 EF_GTP-bd_dom
     IPR023115 TIF_IF2_dom3
     IPR005225 Small_GTP-bd_dom
     IPR004161 Transl_elong_EFTu/EF1A_2

    Graphical View of Domain Structure for InterPro Entry O60841

    ProtoNet protein and cluster: O60841

    UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841
    Similarity: Belongs to the IF-2 family


    EIF5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF2P_HUMAN, O60841
    Function: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to
    ribosomes. Seems to function along with eIF-2 (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity NAS10200264
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI12569173
    GO:0005525GTP binding IEA--
         
    EIF5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EIF5B:
     Decreased viability 

    Animal Models:
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    hsa-miR-429 hsa-miR-4318 hsa-miR-509-5p hsa-miR-570 hsa-miR-298 hsa-miR-199b-5p hsa-miR-330-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidEIF5B 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF5B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit0.94
    Eukaryotic Translation Initiation0.94
    Cap-dependent Translation Initiation0.94
    Translation0.78
    2Generic Transcription Pathway
    Gene Expression0.47
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Translation Factors
    Translation Factors
    5RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EIF5B
        Translation Factors

    5/6        Reactome Pathways for EIF5B (see all 6)
        Cap-dependent Translation Initiation
    Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Eukaryotic Translation Initiation
    Metabolism of proteins


    1         Kegg Pathway  (Kegg details for EIF5B):
        RNA transport


    EIF5B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/879 Interacting proteins for EIF5B (O608411, 2, 3 ENSP000002893714) via UniProtKB, MINT, STRING, and/or I2D (see all 879)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELL1Q928322, 3, ENSP000002989254MINT-8187685 I2D: score=1 STRING: ENSP00000298925
    ETS1P149211, 3EBI-928530,EBI-913209 I2D: score=1 
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation NAS10200264
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--

    EIF5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EIF5B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF5B (IF2P)

    1 HMDB Compound for EIF5B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for EIF5B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 63.3 23 16461768 (4), 16284619 (3), 18381064 (2), 18758445 (2) (see all 10)
    phosphotyrosine 31.1 1 9598977 (1)
    serine 0 2 10712589 (1), 14607111 (1)

    Search CenterWatch for drugs/clinical trials and news about EIF5B / IF2P

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF5B gene: 
    NM_015904.3  

    Unigene Cluster for EIF5B:

    Eukaryotic translation initiation factor 5B
    Hs.158688  [show with all ESTs]
    Unigene Representative Sequence: NM_015904
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289371(uc002tab.3 uc010yvq.2) ENST00000470868 ENST00000494190
    ENST00000470023
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF5B (see all 18):
    hsa-miR-429 hsa-miR-4318 hsa-miR-509-5p hsa-miR-570 hsa-miR-298 hsa-miR-199b-5p hsa-miR-330-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidEIF5B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB018284.1 AF078035.1 AJ006412.1 AJ006776.1 AK001386.1 AK091864.1 AK308175.1 AK308176.1 
    AL133563.1 BC006970.1 BC022260.1 BC032639.1 

    24/47 DOTS entries (see all 47):

    DT.115828  DT.95207194  DT.100037843  DT.91682701  DT.100827572  DT.91652870  DT.86999396  DT.97857766 
    DT.91765315  DT.120952507  DT.100827569  DT.95139591  DT.102843417  DT.100827565  DT.120952415  DT.87008566 
    DT.120952404  DT.75102490  DT.120952335  DT.120952392  DT.120952465  DT.120952551  DT.97770770  DT.100800390 

    24/556 AceView cDNA sequences (see all 556):

    AI522228 CN485327 BM456168 AJ006412 AI301442 AA197157 BF195451 AB018284 
    AI590303 F24780 BF063922 BF063994 AI167243 BG031641 AL700848 AA045408 
    AW470948 AI917101 F21081 AA977243 BM999905 CB107479 BM971043 BG941336 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF5B expression in normal human tissues (normalized intensities)      EIF5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCCACAGT
    EIF5B Expression
    About this image


    EIF5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)
             Bone marrow-derived hematopoietic stem cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Endothelium (Cardiovascular System)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Eye (Sensory Organs)
             lens   
     
     Ovary (Reproductive System)

    See EIF5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF5B

    SOURCE GeneReport for Unigene cluster: Hs.158688
        SABiosciences Expression via Pathway-Focused PCR Arrays including EIF5B: 
              Telomeres & Telomerase in human mouse rat
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF5B gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif5b1 , 5 eukaryotic translation initiation factor 5B1, 5 87.81(n)1
    91.93(a)1
      1 (16.40 cM)5
    2269821  NM_198303.21  NP_938045.21 
     379980105 
    chicken
    (Gallus gallus)
    Aves EIF5B1 eukaryotic translation initiation factor 5B 78.6(n)
    84.96(a)
      395514  NM_001038496.1  NP_001033585.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF5B6
    eukaryotic translation initiation factor 5B
    81(a)
    1 ↔ 1
    GL343456.1(35008-77540)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68002 Xenopus laevis transcribed sequence with moderate similarity more 80.36(n)    CB209494.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eif5b1 eukaryotic translation initiation factor 5B 67.12(n)
    74.38(a)
      561194  XM_001923538.4  XP_001923573.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF5B1 CG10840-PB 56.24(n)
    55.97(a)
      44261  NM_143717.2  NP_651974.1 
    worm
    (Caenorhabditis elegans)
    Secernentea iffb-11 Protein IFFB-1 53.38(n)
    46.72(a)
      175353  NM_065135.5  NP_497536.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FUN12(YAL035W)4
    FUN121
    GTPase, required for general translation initiation more4
    Fun12p1
    53.37(n)1
    45.97(a)1
      1(76427-79435)4
    8511961, 4  NP_009365.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G768101 translation initiation factor eIF-5B 51.65(n)
    44.36(a)
      844015  NM_106331.4  NP_177807.3 
    rice
    (Oryza sativa)
    Liliopsida AK073484.12   -- 78.65(n)    AK073484.1 


    ENSEMBL Gene Tree for EIF5B (if available)
    TreeFam Gene Tree for EIF5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1158 SNPs in EIF5B are shown (see all 1158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443839201,2
    --99954894(+) CGTACA/GCTACC 1 -- int10--------
    rs1409788251,2
    --99955009(+) TTTACC/TAATTA 1 -- int10--------
    rs170225841,2
    C,F,H--99955047(+) ACCTAG/ACGTTT 1 -- int110Minor allele frequency- A:0.03NA NS EA WA 684
    rs1823087091,2
    --99955067(+) ATGAGC/TAGAAT 1 -- int10--------
    rs1864349291,2
    --99955115(+) GGTCTA/GTTGGA 1 -- int10--------
    rs106441721,2
    C--99955385(+) GTGTG-/TGTA  
            
    tatat
    1 -- int10--------
    rs105547481,2
    C--99955429(+) TATAA-/ATATATA 1 -- int10--------
    rs608234471,2
    C--99955440(+) ATATA-/TACAAAT 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs1906522931,2
    --99955479(+) TTTTTC/TTTTTT 1 -- int10--------
    rs356376271,2
    C,F--99955509(+) TGTTGC/TCCAGA 1 -- int12Minor allele frequency- T:0.50NA 4

    HapMap Linkage Disequilibrium report for EIF5B (99953816 - 100016728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EIF5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524466CNV Loss19592680
    nsv874699CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606086    OMIM disorders: --

    15 diseases for EIF5B:    About MalaCards
    von hippel-lindau disease    glucose intolerance    vitiligo    acute promyelocytic leukemia
    polycythemia    germ cell tumors    insulin resistance    obesity
    tuberculosis    prostate cancer    leukemia    endotheliitis
    hepatitis    breast cancer    prostatitis


    EIF5B for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for EIF5B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 0.383 2 7799945 (1), 14981762 (1)
    tumors 0 2 8863671 (2)


    Export disorders for EIF5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF5B gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with EIF5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2 and its interaction with HIV-1 matrix. (PubMed id 10432305)1, 2, 3 Wilson S.A....Martin-Rendon E. (1999)
    2. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. (PubMed id 10200264)1, 2, 3 Lee J.H.... Dever T.E. (1999)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
    5. Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. (PubMed id 12569173)1, 9 Marintchev A....Wagner G. (2003)
    6. Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PubMed id 12514125)1, 9 Olsen D.S....Hinnebusch A.G. (2003)
    7. Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases. (PubMed id 18572216)1, 9 de Breyne S....Hellen C.U. (2008)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9669 HGNC: 30793 AceView: EIF5B Ensembl:ENSG00000158417 euGenes: HUgn9669
    ECgene: EIF5B Kegg: 9669 H-InvDB: EIF5B

    (According to HUGE)
    About This Section
    HUGE: KIAA0741

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EIF5B gene:
    Search GeneIP for patents involving EIF5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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