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EIF5B Gene

protein-coding   GIFtS: 59
GCID: GC02P099953

Eukaryotic Translation Initiation Factor 5B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 5B1 2
Translation Initiation Factor IF21 2
Translation Initiation Factor IF-22 3
IF22 3
eIF-5B2 3
KIAA07413

External Ids:    HGNC: 307931   Entrez Gene: 96692   Ensembl: ENSG000001584177   OMIM: 6060865   UniProtKB: O608413   

Export aliases for EIF5B gene to outside databases

Previous GC identifers: GC02P099575 GC02P099412 GC02P099320 GC02P093719


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF5B Gene:
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed
of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2,
IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is
eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation
factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation
initiates accurately. (provided by RefSeq, Jul 2008)

GeneCards Summary for EIF5B Gene:
EIF5B (eukaryotic translation initiation factor 5B) is a protein-coding gene. GO annotations related to this gene include GTP binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841
Function: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to
ribosomes. Seems to function along with eIF-2 (By similarity)

Gene Wiki entry for EIF5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF5B gene promoter:
         Elk-1   NF-YA   AREB6   NF-YB   IRF-2   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF5B promoter sequence
   Search Chromatin IP Primers for EIF5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

EIF5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF5B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P099953:  view genomic region     (about GC identifiers)

Start:
99,953,816 bp from pter      End:
100,017,789 bp from pter
Size:
63,974 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 5B  
Size: 1220 amino acids; 138827 Da
Subunit: Interacts with ANXA5 in a calcium and phospholipid-dependent manner (By similarity)
Sequence caution: Sequence=BAA34461.2; Type=Erroneous initiation;
Secondary accessions: O95805 Q53RV7 Q53SI8 Q9UF81 Q9UMN7

Explore the universe of human proteins at neXtProt for EIF5B: NX_O60841

Explore proteomics data for EIF5B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys932, Lys1185
  • Modification sites at PhosphoSitePlus

  • See EIF5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056988.3  
    ENSEMBL proteins: 
     ENSP00000289371  
    Reactome Protein details: O60841

    EIF5B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for EIF5B

     
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    Cloud-Clone Corp. ELISAs for EIF5B
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    Search eBioscience for ELISAs for EIF5B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR027417 P-loop_NTPase
     IPR000795 EF_GTP-bd_dom
     IPR023115 TIF_IF2_dom3
     IPR005225 Small_GTP-bd_dom
     IPR004161 Transl_elong_EFTu/EF1A_2

    Graphical View of Domain Structure for InterPro Entry O60841

    ProtoNet protein and cluster: O60841

    UniProtKB/Swiss-Prot: IF2P_HUMAN, O60841
    Similarity: Belongs to the IF-2 family


    Find genes that share domains with EIF5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF2P_HUMAN, O60841
    Function: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to
    ribosomes. Seems to function along with eIF-2 (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity NAS10200264
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI12569173
    GO:0005525GTP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with EIF5B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EIF5B:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF5B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF5B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF5B

    miRNA
    Products:
        
    miRTarBase miRNAs that target EIF5B:
    hsa-mir-15b-5p (MIRT046523), hsa-mir-484 (MIRT042049), hsa-mir-16-5p (MIRT031635)

    Block miRNA regulation of human, mouse, rat EIF5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF5B (see all 18):
    hsa-miR-429 hsa-miR-4318 hsa-miR-509-5p hsa-miR-570 hsa-miR-298 hsa-miR-199b-5p hsa-miR-330-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidEIF5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EIF5B
    Predesigned siRNA for gene silencing in human, mouse, rat EIF5B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: EIF5B (NM_015904)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF5B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IF2P_HUMAN, O60841: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with EIF5B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF5B About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Eukaryotic Translation Initiation0.89
    Cap-dependent Translation Initiation0.89
    Translation0.82
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Translation Factors
    Translation Factors
    5RNA transport
    RNA transport


    Find genes that share SuperPaths with EIF5B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EIF5B
        Translation Factors

    1 Reactome Pathway for EIF5B
        GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for EIF5B):
        RNA transport

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EIF5B: 
              Telomeres & Telomerase in human mouse rat
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EIF5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF5B (O608411, 2, 3 ENSP000002893714) via UniProtKB, MINT, STRING, and/or I2D (see all 937)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELL1Q928322, 3, ENSP000002989254MINT-8187685 I2D: score=1 STRING: ENSP00000298925
    ETS1P149211, 3EBI-928530,EBI-913209 I2D: score=1 
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation NAS10200264
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with EIF5B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF5B (IF2P)

    1 HMDB Compound for EIF5B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for EIF5B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 63.3 23 16461768 (4), 16284619 (3), 18381064 (2), 18758445 (2) (see all 10)
    phosphotyrosine 31.1 1 9598977 (1)
    serine 0 2 10712589 (1), 14607111 (1)



    Find genes that share compounds with EIF5B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF5B gene: 
    NM_015904.3  

    Unigene Cluster for EIF5B:

    Eukaryotic translation initiation factor 5B
    Hs.158688  [show with all ESTs]
    Unigene Representative Sequence: NM_015904
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289371(uc002tab.3 uc010yvq.2) ENST00000470868 ENST00000494190
    ENST00000470023
    miRNA
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    Block miRNA regulation of human, mouse, rat EIF5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF5B (see all 18):
    hsa-miR-429 hsa-miR-4318 hsa-miR-509-5p hsa-miR-570 hsa-miR-298 hsa-miR-199b-5p hsa-miR-330-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidEIF5B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EIF5B
    Clone
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    OriGene ORF clones in mouse, rat for EIF5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF5B (NM_015904)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF5B
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat EIF5B
      QuantiFast Probe-based Assays in human, mouse, rat EIF5B

    Additional mRNA sequence: 

    AB018284.1 AF078035.1 AJ006412.1 AJ006776.1 AK001386.1 AK091864.1 AK308175.1 AK308176.1 
    AL133563.1 BC006970.1 BC022260.1 BC032639.1 

    Selected DOTS entries (see all 47):

    DT.115828  DT.95207194  DT.100037843  DT.91682701  DT.100827572  DT.91652870  DT.86999396  DT.97857766 
    DT.91765315  DT.120952507  DT.100827569  DT.95139591  DT.102843417  DT.100827565  DT.120952415  DT.87008566 
    DT.120952404  DT.75102490  DT.120952335  DT.120952392  DT.120952465  DT.120952551  DT.97770770  DT.100800390 

    Selected AceView cDNA sequences (see all 556):

    BG942939 BG941637 BM698174 AI201421 BP363043 BF063922 BF063994 AA112002 
    AW470948 AA180796 BG941697 AI917101 BU186301 BI091981 BU194723 AW237263 
    BG777759 AL133563 BG942223 BM543001 BG187857 AA554283 AA988620 BE936017 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCCACAGT
    EIF5B Expression
    About this image


    EIF5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Ovary (Reproductive System)
    EIF5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158688
        Pathway & Disease-focused RT2 Profiler PCR Arrays including EIF5B: 
              Telomeres & Telomerase in human mouse rat
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF5B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF5B
    QuantiTect SYBR Green Assays in human, mouse, rat EIF5B
    QuantiFast Probe-based Assays in human, mouse, rat EIF5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF5B gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif5b1 , 5 eukaryotic translation initiation factor 5B1, 5 87.15(n)1
    90.61(a)1
      1 (16.40 cM)5
    2269821  NM_198303.21  NP_938045.21 
     379980105 
    chicken
    (Gallus gallus)
    Aves EIF5B1 eukaryotic translation initiation factor 5B 78.24(n)
    84.79(a)
      395514  NM_001038496.1  NP_001033585.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF5B6
    eukaryotic translation initiation factor 5B
    83(a)
    1 ↔ 1
    GL343456.1(35008-77540)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68002 Xenopus laevis transcribed sequence with moderate similarity more 80.36(n)    CB209494.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eif5b1 eukaryotic translation initiation factor 5B 65.96(n)
    71.4(a)
      561194  XM_001923538.5  XP_001923573.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF5B6
    eIF5B
    52(a)
    1 ↔ 1
    3L(3428658-3460977)
    worm
    (Caenorhabditis elegans)
    Secernentea iffb-16
    Protein IFFB-1 (iffb-1) mRNA, complete cds
    45(a)
    1 ↔ 1
    III(2314436-2326901) WBGene00021857
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FUN12(YAL035W)4 GTPase, required for general translation initiation more   --   1(76427-79435) 851196  NP_009365.1 
    soybean
    (Glycine max)
    eudicotyledons BM269948.12   -- 80.37(n)    BM269948.1 
    rice
    (Oryza sativa)
    Liliopsida AK073484.12   -- 78.65(n)    AK073484.1 


    ENSEMBL Gene Tree for EIF5B (if available)
    TreeFam Gene Tree for EIF5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF5B (see all 1158)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443839201,2
    --99954894(+) CGTACA/GCTACC 1 -- int10--------
    rs1409788251,2
    --99955009(+) TTTACC/TAATTA 1 -- int10--------
    rs170225841,2
    C,F,H--99955047(+) ACCTAG/ACGTTT 1 -- int110Minor allele frequency- A:0.03NA NS EA WA 684
    rs1823087091,2
    --99955067(+) ATGAGC/TAGAAT 1 -- int10--------
    rs1864349291,2
    --99955115(+) GGTCTA/GTTGGA 1 -- int10--------
    rs106441721,2
    C--99955385(+) GTGTG-/TGTA  
            
    tatat
    1 -- int10--------
    rs105547481,2
    C--99955429(+) TATAA-/ATATATA 1 -- int10--------
    rs608234471,2
    C--99955440(+) ATATA-/TACAAAT 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs1906522931,2
    --99955479(+) TTTTTC/TTTTTT 1 -- int10--------
    rs356376271,2
    C,F--99955509(+) TGTTGC/TCCAGA 1 -- int12Minor allele frequency- T:0.50NA 4

    HapMap Linkage Disequilibrium report for EIF5B (99953816 - 100017789 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EIF5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524466CNV Loss19592680
    nsv874699CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF5B
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606086    OMIM disorders: --


    Find genes that share disorders with EIF5B           About GenesLikeMe

    2 Novoseek inferred disease relationships for EIF5B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 0.383 2 7799945 (1), 14981762 (1)
    tumors 0 2 8863671 (2)


    Export disorders for EIF5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF5B gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with EIF5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2 and its interaction with HIV-1 matrix. (PubMed id 10432305)1, 2, 3 Wilson S.A....Martin-Rendon E. (Biochem. J. 1999)
    2. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. (PubMed id 10200264)1, 2, 3 Lee J.H.... Dever T.E. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    5. Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. (PubMed id 12569173)1, 9 Marintchev A....Wagner G. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PubMed id 12514125)1, 9 Olsen D.S....Hinnebusch A.G. (EMBO J. 2003)
    7. Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases. (PubMed id 18572216)1, 9 de Breyne S....Hellen C.U. (Virology 2008)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9669 HGNC: 30793 AceView: EIF5B Ensembl:ENSG00000158417 euGenes: HUgn9669
    ECgene: EIF5B Kegg: 9669 H-InvDB: EIF5B

    (According to HUGE)
    About This Section

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    HUGE: KIAA0741

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EIF5B gene:
    Search GeneIP for patents involving EIF5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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