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Aliases for EIF5A2 Gene

Aliases for EIF5A2 Gene

  • Eukaryotic Translation Initiation Factor 5A2 2 3 5
  • EIF-5A-2 3 4
  • EIF-5A2 3 4
  • Eukaryotic Translation Initiation Factor 5A-2 3
  • Eukaryotic Initiation Factor 5A Isoform 2 4
  • Eukaryotic Initiation Factor 5A 3
  • EIF5AII 3

External Ids for EIF5A2 Gene

Previous GeneCards Identifiers for EIF5A2 Gene

  • GC03M167752
  • GC03M171659
  • GC03M172010
  • GC03M171927
  • GC03M172088
  • GC03M170607
  • GC03M167976

Summaries for EIF5A2 Gene

GeneCards Summary for EIF5A2 Gene

EIF5A2 (Eukaryotic Translation Initiation Factor 5A2) is a Protein Coding gene. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Metabolism of proteins. GO annotations related to this gene include RNA binding and translation elongation factor activity. An important paralog of this gene is EIF5A.

UniProtKB/Swiss-Prot for EIF5A2 Gene

  • mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Gene Wiki entry for EIF5A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF5A2 Gene

Genomics for EIF5A2 Gene

Regulatory Elements for EIF5A2 Gene

Enhancers for EIF5A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G170723 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +182.1 182060 5.7 HDGF ARNT SIN3A YBX1 ZNF766 ELK1 GATA2 FOS CAVIN1 JUNB LOC101928583 EIF5A2 CLDN11 RPL22L1 ENSG00000239739
GH03G170907 1.4 FANTOM5 ENCODE 5.7 -0.1 -124 2.9 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF302 CBX5 ZNF548 SEC62-AS1 RPL22L1 EIF5A2 GC03M170953
GH03G170808 1.6 FANTOM5 Ensembl ENCODE 3.5 +97.2 97156 6.6 HDGF ATF1 PKNOX1 ARNT ZNF133 BRCA1 ZNF2 ZNF766 GATA2 ZNF143 CLDN11 ENSG00000242578 RPL22L1 LOC101928583 EIF5A2 RNY5P3 LOC105374211
GH03G170953 0.6 dbSUPER 4.8 -45.1 -45146 0.8 ATF1 RNF2 POLR2A SMARCA4 IKZF1 ZNF512 ATF2 RPL22L1 SLC2A2 EIF5A2 GC03M170953
GH03G170749 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.5 +156.2 156151 6.9 PKNOX1 SIN3A FEZF1 ZNF121 ZNF766 GATA2 FOS TSHZ1 ZNF592 SMARCA4 LOC101928583 CLDN11 EIF5A2 ENSG00000239739 LOC105374211
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF5A2 on UCSC Golden Path with GeneCards custom track

Promoters for EIF5A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000161698 393 1401 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF302 CBX5 ZNF548

Genomic Location for EIF5A2 Gene

Chromosome:
3
Start:
170,888,415 bp from pter
End:
170,908,693 bp from pter
Size:
20,279 bases
Orientation:
Minus strand

Genomic View for EIF5A2 Gene

Genes around EIF5A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF5A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF5A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5A2 Gene

Proteins for EIF5A2 Gene

  • Protein details for EIF5A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZV4-IF5A2_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5A-2
    Protein Accession:
    Q9GZV4
    Secondary Accessions:
    • B2R4V5

    Protein attributes for EIF5A2 Gene

    Size:
    153 amino acids
    Molecular mass:
    16793 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EIF5A2 Gene

Post-translational modifications for EIF5A2 Gene

  • eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF5A2 Gene

No data available for DME Specific Peptides for EIF5A2 Gene

Domains & Families for EIF5A2 Gene

Suggested Antigen Peptide Sequences for EIF5A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZV4

UniProtKB/Swiss-Prot:

IF5A2_HUMAN :
  • Belongs to the eIF-5A family.
Family:
  • Belongs to the eIF-5A family.
genes like me logo Genes that share domains with EIF5A2: view

No data available for Gene Families for EIF5A2 Gene

Function for EIF5A2 Gene

Molecular function for EIF5A2 Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
GO:0005515 protein binding IPI 14622290
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with EIF5A2: view

Phenotypes for EIF5A2 Gene

genes like me logo Genes that share phenotypes with EIF5A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5A2 Gene

Localization for EIF5A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF5A2 Gene

Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF5A2 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with EIF5A2: view

Pathways & Interactions for EIF5A2 Gene

genes like me logo Genes that share pathways with EIF5A2: view

Gene Ontology (GO) - Biological Process for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006414 translational elongation IEA --
GO:0006452 translational frameshifting IEA --
GO:0006810 transport IEA --
GO:0007283 spermatogenesis NAS 11161802
genes like me logo Genes that share ontologies with EIF5A2: view

No data available for SIGNOR curated interactions for EIF5A2 Gene

Drugs & Compounds for EIF5A2 Gene

(1) Additional Compounds for EIF5A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hypusine
  • N(6)-(4-Amino-2-hydroxybutyl)-L-lysine
34994-11-1
genes like me logo Genes that share compounds with EIF5A2: view

Transcripts for EIF5A2 Gene

Unigene Clusters for EIF5A2 Gene

Eukaryotic translation initiation factor 5A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: - -
SP4: - -

Relevant External Links for EIF5A2 Gene

GeneLoc Exon Structure for
EIF5A2
ECgene alternative splicing isoforms for
EIF5A2

Expression for EIF5A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF5A2 Gene

Protein differential expression in normal tissues from HIPED for EIF5A2 Gene

This gene is overexpressed in Saliva (25.4), Heart (15.3), Plasma (8.8), and Urine (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF5A2 Gene



Protein tissue co-expression partners for EIF5A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF5A2 Gene:

EIF5A2

SOURCE GeneReport for Unigene cluster for EIF5A2 Gene:

Hs.164144

mRNA Expression by UniProt/SwissProt for EIF5A2 Gene:

Q9GZV4-IF5A2_HUMAN
Tissue specificity: Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.

Evidence on tissue expression from TISSUES for EIF5A2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with EIF5A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF5A2 Gene

Orthologs for EIF5A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF5A2 34 35
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF5A2 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF5A2 34 35
  • 95.86 (n)
dog
(Canis familiaris)
Mammalia EIF5A2 34 35
  • 94.99 (n)
mouse
(Mus musculus)
Mammalia Eif5a2 34 16 35
  • 94.12 (n)
rat
(Rattus norvegicus)
Mammalia Eif5a2 34
  • 93.25 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF5A2 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF5A2 34 35
  • 81.7 (n)
lizard
(Anolis carolinensis)
Reptilia EIF5A2 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.290 34
African clawed frog
(Xenopus laevis)
Amphibia iff-2-prov 34
zebrafish
(Danio rerio)
Actinopterygii eif5a 35
  • 75 (a)
OneToMany
eif5a2 35
  • 74 (a)
OneToMany
pax6a 34
fruit fly
(Drosophila melanogaster)
Insecta eIF-5A 36 35
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea iff-2 36 35
  • 63 (a)
iff-1 36 35
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ANB1 35 37
  • 62 (a)
ManyToMany
HYP2 35
  • 62 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.15407 34
barley
(Hordeum vulgare)
Liliopsida Hv.7334 34
rice
(Oryza sativa)
Liliopsida Os.6385 34
corn
(Zea mays)
Liliopsida Zm.761 34
Species where no ortholog for EIF5A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF5A2 Gene

ENSEMBL:
Gene Tree for EIF5A2 (if available)
TreeFam:
Gene Tree for EIF5A2 (if available)

Paralogs for EIF5A2 Gene

Paralogs for EIF5A2 Gene

(2) SIMAP similar genes for EIF5A2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for EIF5A2 Gene

genes like me logo Genes that share paralogs with EIF5A2: view

Variants for EIF5A2 Gene

Sequence variations from dbSNP and Humsavar for EIF5A2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000100359 -- 170,900,199(+) AACCT(C/G/T)GTCTC intron-variant
rs1000231879 -- 170,907,413(+) GTCAC(C/T)AGGAT intron-variant
rs1000696157 -- 170,890,481(+) AGTGA(C/T)TGAGC utr-variant-3-prime
rs1000777466 -- 170,910,474(+) CCTCT(A/G)CACCC upstream-variant-2KB
rs1001207487 -- 170,897,608(+) GGCAA(C/G)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF5A2 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER inversion 18451855

Variation tolerance for EIF5A2 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF5A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF5A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5A2 Gene

Disorders for EIF5A2 Gene

Relevant External Links for EIF5A2

Genetic Association Database (GAD)
EIF5A2
Human Genome Epidemiology (HuGE) Navigator
EIF5A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF5A2

No disorders were found for EIF5A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF5A2 Gene

Publications for EIF5A2 Gene

  1. Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. (PMID: 16519677) Clement P.M.J. … Park M.H. (FEBS J. 2006) 3 4 22 64
  2. Screening the SPO11 and EIF5A2 genes in a population of infertile men. (PMID: 16169419) Christensen G.L. … Carrell D.T. (Fertil. Steril. 2005) 3 4 46 64
  3. Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression. (PMID: 11161802) Jenkins Z.A. … Johansson H.E. (Genomics 2001) 3 4 22 64
  4. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. (PMID: 11325856) Guan X.-Y.Y. … Yang J.-M. (Cancer Res. 2001) 3 4 22 64
  5. Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. (PMID: 20112425) Tang D.J. … Guan X.Y. (Hepatology 2010) 3 22 64

Products for EIF5A2 Gene

Sources for EIF5A2 Gene

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