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Aliases for EIF5A2 Gene

Aliases for EIF5A2 Gene

  • Eukaryotic Translation Initiation Factor 5A2 2 3
  • EIF-5A-2 3 4
  • EIF-5A2 3 4
  • Eukaryotic Initiation Factor 5A Isoform 2 4
  • Eukaryotic Initiation Factor 5A 3
  • EIF5AII 3

External Ids for EIF5A2 Gene

Previous GeneCards Identifiers for EIF5A2 Gene

  • GC03M167752
  • GC03M171659
  • GC03M172010
  • GC03M171927
  • GC03M172088
  • GC03M170607
  • GC03M167976

Summaries for EIF5A2 Gene

GeneCards Summary for EIF5A2 Gene

EIF5A2 (Eukaryotic Translation Initiation Factor 5A2) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Transport to the Golgi and subsequent modification. GO annotations related to this gene include RNA binding and translation elongation factor activity. An important paralog of this gene is EIF5AL1.

UniProtKB/Swiss-Prot for EIF5A2 Gene

  • mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Gene Wiki entry for EIF5A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF5A2 Gene

Genomics for EIF5A2 Gene

Regulatory Elements for EIF5A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF5A2 Gene

Chromosome:
3
Start:
170,888,415 bp from pter
End:
170,908,693 bp from pter
Size:
20,279 bases
Orientation:
Minus strand

Genomic View for EIF5A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF5A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5A2 Gene

Proteins for EIF5A2 Gene

  • Protein details for EIF5A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZV4-IF5A2_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5A-2
    Protein Accession:
    Q9GZV4
    Secondary Accessions:
    • B2R4V5

    Protein attributes for EIF5A2 Gene

    Size:
    153 amino acids
    Molecular mass:
    16793 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EIF5A2 Gene

Proteomics data for EIF5A2 Gene at MOPED

Post-translational modifications for EIF5A2 Gene

  • eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine)
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF5A2 Gene

Antibody Products

No data available for DME Specific Peptides for EIF5A2 Gene

Domains & Families for EIF5A2 Gene

Suggested Antigen Peptide Sequences for EIF5A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZV4

UniProtKB/Swiss-Prot:

IF5A2_HUMAN :
  • Belongs to the eIF-5A family.
Family:
  • Belongs to the eIF-5A family.
genes like me logo Genes that share domains with EIF5A2: view

No data available for Gene Families for EIF5A2 Gene

Function for EIF5A2 Gene

Molecular function for EIF5A2 Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003746 translation elongation factor activity IEA --
GO:0005515 protein binding IPI 14622290
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with EIF5A2: view

Phenotypes for EIF5A2 Gene

GenomeRNAi human phenotypes for EIF5A2:
genes like me logo Genes that share phenotypes with EIF5A2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF5A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5A2 Gene

Localization for EIF5A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF5A2 Gene

Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF5A2 Gene COMPARTMENTS Subcellular localization image for EIF5A2 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 3
nucleus 3

Gene Ontology (GO) - Cellular Components for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF5A2: view

Pathways & Interactions for EIF5A2 Gene

genes like me logo Genes that share pathways with EIF5A2: view

Gene Ontology (GO) - Biological Process for EIF5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006452 translational frameshifting IEA --
GO:0007283 spermatogenesis NAS 11161802
GO:0008284 positive regulation of cell proliferation IGI 14622290
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS --
GO:0010509 polyamine homeostasis NAS 11161802
genes like me logo Genes that share ontologies with EIF5A2: view

No data available for SIGNOR curated interactions for EIF5A2 Gene

Drugs & Compounds for EIF5A2 Gene

(1) Additional Compounds for EIF5A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hypusine
  • N(6)-(4-Amino-2-hydroxybutyl)-L-lysine
34994-11-1
genes like me logo Genes that share compounds with EIF5A2: view

Transcripts for EIF5A2 Gene

Unigene Clusters for EIF5A2 Gene

Eukaryotic translation initiation factor 5A2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF5A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: - -
SP4: - -

Relevant External Links for EIF5A2 Gene

GeneLoc Exon Structure for
EIF5A2
ECgene alternative splicing isoforms for
EIF5A2

Expression for EIF5A2 Gene

mRNA expression in normal human tissues for EIF5A2 Gene

Protein differential expression in normal tissues from HIPED for EIF5A2 Gene

This gene is overexpressed in Saliva (25.4), Heart (15.3), Plasma (8.8), and Urine (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF5A2 Gene



SOURCE GeneReport for Unigene cluster for EIF5A2 Gene Hs.164144

mRNA Expression by UniProt/SwissProt for EIF5A2 Gene

Q9GZV4-IF5A2_HUMAN
Tissue specificity: Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.
genes like me logo Genes that share expression patterns with EIF5A2: view

Protein tissue co-expression partners for EIF5A2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF5A2 Gene

Orthologs for EIF5A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF5A2 35
  • 95.86 (n)
  • 100 (a)
EIF5A2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF5A2 35
  • 94.99 (n)
  • 100 (a)
EIF5A2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif5a2 35
  • 94.12 (n)
  • 100 (a)
Eif5a2 16
Eif5a2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF5A2 35
  • 100 (n)
  • 100 (a)
EIF5A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif5a2 35
  • 93.25 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF5A2 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF5A2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF5A2 35
  • 81.7 (n)
  • 92.16 (a)
EIF5A2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF5A2 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.290 35
African clawed frog
(Xenopus laevis)
Amphibia iff-2-prov 35
zebrafish
(Danio rerio)
Actinopterygii pax6a 35
eif5a 36
  • 75 (a)
OneToMany
eif5a2 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF-5A 37
  • 68 (a)
eIF-5A 36
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea iff-1 37
  • 58 (a)
iff-2 37
  • 63 (a)
iff-1 36
  • 45 (a)
ManyToMany
iff-2 36
  • 58 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ANB1 36
  • 62 (a)
ManyToMany
HYP2 36
  • 62 (a)
ManyToMany
ANB1 38
soybean
(Glycine max)
eudicotyledons Gma.15407 35
barley
(Hordeum vulgare)
Liliopsida Hv.7334 35
rice
(Oryza sativa)
Liliopsida Os.6385 35
corn
(Zea mays)
Liliopsida Zm.761 35
Species with no ortholog for EIF5A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF5A2 Gene

ENSEMBL:
Gene Tree for EIF5A2 (if available)
TreeFam:
Gene Tree for EIF5A2 (if available)

Paralogs for EIF5A2 Gene

Paralogs for EIF5A2 Gene

(2) SIMAP similar genes for EIF5A2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for EIF5A2 Gene

genes like me logo Genes that share paralogs with EIF5A2: view

Variants for EIF5A2 Gene

Sequence variations from dbSNP and Humsavar for EIF5A2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1356012 -- 170,900,974(+) attta(C/T)ctaat intron-variant
rs1356013 -- 170,901,010(+) tcctg(C/G/T)taaag intron-variant
rs1384976 -- 170,892,444(-) ctttt(C/T)ttttt utr-variant-3-prime
rs1384977 -- 170,892,406(-) catca(C/G)ccagg utr-variant-3-prime
rs1879441 -- 170,904,925(+) CTTGT(C/T)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF5A2 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877978 CNV Loss 21882294

Variation tolerance for EIF5A2 Gene

Residual Variation Intolerance Score: 41.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF5A2 Gene

HapMap Linkage Disequilibrium report
EIF5A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5A2 Gene

Disorders for EIF5A2 Gene

Relevant External Links for EIF5A2

Genetic Association Database (GAD)
EIF5A2
Human Genome Epidemiology (HuGE) Navigator
EIF5A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF5A2
genes like me logo Genes that share disorders with EIF5A2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF5A2 Gene

Publications for EIF5A2 Gene

  1. Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. (PMID: 20112425) Tang D.J. … Guan X.Y. (Hepatology 2010) 23 67
  2. Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. (PMID: 16519677) Clement P.M.J. … Park M.H. (FEBS J. 2006) 23 67
  3. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. (PMID: 11325856) Guan X.-Y.Y. … Yang J.-M. (Cancer Res. 2001) 23 67
  4. Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression. (PMID: 11161802) Jenkins Z.A. … Johansson H.E. (Genomics 2001) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for EIF5A2 Gene

Sources for EIF5A2 Gene

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