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Aliases for EIF5A Gene

Aliases for EIF5A Gene

  • Eukaryotic Translation Initiation Factor 5A 2 3
  • Rev-Binding Factor 3 4
  • EIF-5A-1 3 4
  • EIF-5A1 3 4
  • EIF-5A 3 4
  • EIF-4D 3 4
  • Eukaryotic Initiation Factor 5A Isoform 1 4
  • Eukaryotic Initiation Factor 5A 3
  • EIF5A1 3
  • EIF5AI 3

External Ids for EIF5A Gene

Previous GeneCards Identifiers for EIF5A Gene

  • GC17P007609
  • GC17P007940
  • GC17P007153
  • GC17P007411
  • GC17P007412
  • GC17P007151
  • GC17P007210
  • GC17P007104

Summaries for EIF5A Gene

GeneCards Summary for EIF5A Gene

EIF5A (Eukaryotic Translation Initiation Factor 5A) is a Protein Coding gene. Diseases associated with EIF5A include hiv-1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and protein N-terminus binding. An important paralog of this gene is EIF5A2.

UniProtKB/Swiss-Prot for EIF5A Gene

  • mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

Gene Wiki entry for EIF5A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF5A Gene

Genomics for EIF5A Gene

Regulatory Elements for EIF5A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF5A Gene

Chromosome:
17
Start:
7,306,999 bp from pter
End:
7,312,463 bp from pter
Size:
5,465 bases
Orientation:
Plus strand

Genomic View for EIF5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5A Gene

Proteins for EIF5A Gene

  • Protein details for EIF5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63241-IF5A1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5A-1
    Protein Accession:
    P63241
    Secondary Accessions:
    • A8K9A0
    • D3DTP2
    • P10159
    • Q16182
    • Q7L7L3
    • Q7Z4L1
    • Q9D0G2

    Protein attributes for EIF5A Gene

    Size:
    154 amino acids
    Molecular mass:
    16832 Da
    Quaternary structure:
    • Interacts with DHPS, with SDCBP and DOHH. Interacts with HIV-1 protein Rev. Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4.

    Three dimensional structures from OCA and Proteopedia for EIF5A Gene

    Alternative splice isoforms for EIF5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF5A Gene

Proteomics data for EIF5A Gene at MOPED

Post-translational modifications for EIF5A Gene

  • Acetylated. Deacetylated by SIRT2.
  • eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine)
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF5A (eIF5A)

No data available for DME Specific Peptides for EIF5A Gene

Domains & Families for EIF5A Gene

Suggested Antigen Peptide Sequences for EIF5A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63241

UniProtKB/Swiss-Prot:

IF5A1_HUMAN :
  • Belongs to the eIF-5A family.
Family:
  • Belongs to the eIF-5A family.
genes like me logo Genes that share domains with EIF5A: view

No data available for Gene Families for EIF5A Gene

Function for EIF5A Gene

Molecular function for EIF5A Gene

GENATLAS Biochemistry:
eukaryotic translation initiation factor 5 A complexing with CRM1,cofactor for the HIV-1 transactivator Rev
UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

Gene Ontology (GO) - Molecular Function for EIF5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 15303967
GO:0003746 translation elongation factor activity ISS --
GO:0005515 protein binding IPI 9442029
GO:0017070 U6 snRNA binding IDA 9285100
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with EIF5A: view
genes like me logo Genes that share phenotypes with EIF5A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5A Gene

Localization for EIF5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF5A Gene

Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF5A Gene COMPARTMENTS Subcellular localization image for EIF5A gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for EIF5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12210765
GO:0005642 annulate lamellae IDA 12210765
GO:0005643 nuclear pore IDA 10381392
GO:0005737 cytoplasm IDA 12210765
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with EIF5A: view

Pathways & Interactions for EIF5A Gene

genes like me logo Genes that share pathways with EIF5A: view

Pathways by source for EIF5A Gene

1 Qiagen pathway for EIF5A Gene
1 Cell Signaling Technology pathway for EIF5A Gene

Gene Ontology (GO) - Biological Process for EIF5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus IMP 9465063
GO:0006452 translational frameshifting IEA --
GO:0006611 protein export from nucleus IMP 8596953
GO:0006913 nucleocytoplasmic transport IMP 10381392
GO:0006915 apoptotic process IDA 15371445
genes like me logo Genes that share ontologies with EIF5A: view

No data available for SIGNOR curated interactions for EIF5A Gene

Drugs & Compounds for EIF5A Gene

(15) Drugs for EIF5A Gene - From: NovoSeek, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved Pharma 957
Mimosine Approved Pharma 0
Ornithine Approved Nutra Full agonist, Agonist 31
S-Adenosylmethionine Approved Nutra 0
spermine Approved Nutra Channel blocker 0

(13) Additional Compounds for EIF5A Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hypusine
  • N(6)-(4-Amino-2-hydroxybutyl)-L-lysine
34994-11-1
1,3-diaminopropane
  • 1,3-Diamino-N-propane
  • 1,3-Propanediamine
  • 1,3-Propylenediamine
  • 1,3-Trimethylenediamine
  • 3-Aminopropylamine
109-76-2
1,7-Diaminoheptane
Actinomycin D
deoxyhypusine
  • N(6)-(4-Aminobutyl)-L-lysine
  • N(6)-(4-Aminobutyl)lysine
82543-85-9
genes like me logo Genes that share compounds with EIF5A: view

Drug Products

Transcripts for EIF5A Gene

Unigene Clusters for EIF5A Gene

Eukaryotic translation initiation factor 5A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF5A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5A Gene

No ASD Table

Relevant External Links for EIF5A Gene

GeneLoc Exon Structure for
EIF5A
ECgene alternative splicing isoforms for
EIF5A

Expression for EIF5A Gene

mRNA expression in normal human tissues for EIF5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF5A Gene

This gene is overexpressed in Salivary gland (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF5A Gene



SOURCE GeneReport for Unigene cluster for EIF5A Gene Hs.534314

mRNA Expression by UniProt/SwissProt for EIF5A Gene

P63241-IF5A1_HUMAN
Tissue specificity: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
genes like me logo Genes that share expression patterns with EIF5A: view

Protein tissue co-expression partners for EIF5A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EIF5A Gene

Orthologs for EIF5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF5A 35
  • 94.59 (n)
  • 100 (a)
EIF5A 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia EIF5A 35
  • 95.02 (n)
  • 98.28 (a)
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif5a 35
  • 97.19 (n)
  • 100 (a)
Eif5a 16
Eif5a 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia EIF5A 35
  • 99.78 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif5a 35
  • 96.54 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eif5a 35
  • 73.59 (n)
  • 85.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20890 35
zebrafish
(Danio rerio)
Actinopterygii eif5a2 35
  • 71.68 (n)
  • 79.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF-5A 37
  • 69 (a)
eIF-5A 36
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea iff-1 37
  • 57 (a)
iff-2 37
  • 61 (a)
iff-1 36
  • 48 (a)
ManyToMany
iff-2 36
  • 59 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ANB1 36
  • 61 (a)
ManyToMany
HYP2 36
  • 62 (a)
ManyToMany
HYP2 38
rice
(Oryza sativa)
Liliopsida Os.23719 35
Species with no ortholog for EIF5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF5A Gene

ENSEMBL:
Gene Tree for EIF5A (if available)
TreeFam:
Gene Tree for EIF5A (if available)

Paralogs for EIF5A Gene

Paralogs for EIF5A Gene

(2) SIMAP similar genes for EIF5A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for EIF5A Gene

genes like me logo Genes that share paralogs with EIF5A: view

Variants for EIF5A Gene

Sequence variations from dbSNP and Humsavar for EIF5A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1007605 -- 7,310,573(+) TAGTT(A/G)TTTCT intron-variant, utr-variant-3-prime
rs1063982 -- 7,312,129(+) ttttt(A/T)AATTC utr-variant-3-prime
rs4467109 -- 7,305,013(-) CCCAG(A/C)TACTT upstream-variant-2KB
rs4796300 -- 7,305,010(+) GGGAA(C/G)TAGCT upstream-variant-2KB
rs4796399 -- 7,310,375(+) TCTTG(A/C)TAGCA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF5A Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294
nsv1963 CNV Loss 18451855
nsv907641 CNV Loss 21882294
nsv509650 CNV Insertion 20534489
nsv827872 CNV Gain 20364138
nsv827873 CNV Gain 20364138

Variation tolerance for EIF5A Gene

Residual Variation Intolerance Score: 54.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF5A Gene

HapMap Linkage Disequilibrium report
EIF5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5A Gene

Disorders for EIF5A Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF5A Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association
Search EIF5A in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF5A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF5A
genes like me logo Genes that share disorders with EIF5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF5A Gene

Publications for EIF5A Gene

  1. The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2. (PMID: 7759117) Steinkasserer A. … Bevec D. (Genomics 1995) 2 23 67
  2. Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway. (PMID: 20232312) Sun Z. … Thompson J.E. (J. Cell. Physiol. 2010) 23 67
  3. eIF5A promotes translation elongation, polysome disassembly and stress granule assembly. (PMID: 20376341) Li C.H. … Anderson P. (PLoS ONE 2010) 23 67
  4. Assessment of deoxyhypusine hydroxylase as a putative, novel drug target. (PMID: 19956997) Kerscher B. … Kaiser A. (Amino Acids 2010) 23 67
  5. Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani. (PMID: 19880510) Chawla B. … Madhubala R. (J. Biol. Chem. 2010) 23 67

Products for EIF5A Gene

  • Addgene plasmids for EIF5A

Sources for EIF5A Gene

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