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Aliases for EIF5 Gene

Aliases for EIF5 Gene

  • Eukaryotic Translation Initiation Factor 5 2 3
  • EIF-5 3 4
  • EIF-5A 3

External Ids for EIF5 Gene

Previous GeneCards Identifiers for EIF5 Gene

  • GC14P101191
  • GC14P097615
  • GC14P101790
  • GC14P102870
  • GC14P103800
  • GC14P083978

Summaries for EIF5 Gene

Entrez Gene Summary for EIF5 Gene

  • Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

GeneCards Summary for EIF5 Gene

EIF5 (Eukaryotic Translation Initiation Factor 5) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for EIF5 Gene

  • Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F])

Gene Wiki entry for EIF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF5 Gene

Genomics for EIF5 Gene

Regulatory Elements for EIF5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF5 Gene

Chromosome:
14
Start:
103,333,544 bp from pter
End:
103,345,025 bp from pter
Size:
11,482 bases
Orientation:
Plus strand

Genomic View for EIF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5 Gene

Proteins for EIF5 Gene

  • Protein details for EIF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55010-IF5_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5
    Protein Accession:
    P55010
    Secondary Accessions:
    • Q53XB3
    • Q9H5N2
    • Q9UG48

    Protein attributes for EIF5 Gene

    Size:
    431 amino acids
    Molecular mass:
    49223 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for EIF5 Gene

neXtProt entry for EIF5 Gene

Proteomics data for EIF5 Gene at MOPED

Post-translational modifications for EIF5 Gene

  • Ubiquitination at Lys 55
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF5 (eIF5)

No data available for DME Specific Peptides for EIF5 Gene

Domains & Families for EIF5 Gene

Suggested Antigen Peptide Sequences for EIF5 Gene

Graphical View of Domain Structure for InterPro Entry

P55010

UniProtKB/Swiss-Prot:

IF5_HUMAN :
  • Contains 1 W2 domain.
  • Belongs to the eIF-2-beta/eIF-5 family.
Domain:
  • Contains 1 W2 domain.
Family:
  • Belongs to the eIF-2-beta/eIF-5 family.
genes like me logo Genes that share domains with EIF5: view

No data available for Gene Families for EIF5 Gene

Function for EIF5 Gene

Molecular function for EIF5 Gene

GENATLAS Biochemistry:
eukaryotic translation initiation factor 5,hydrolyzing GTP of the 40S ribosomal initiation complex
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F])

Gene Ontology (GO) - Molecular Function for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity NAS 8663286
GO:0003924 GTPase activity TAS 8663286
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with EIF5: view
genes like me logo Genes that share phenotypes with EIF5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5 Gene

Localization for EIF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF5 Gene COMPARTMENTS Subcellular localization image for EIF5 gene
Compartment Confidence
cytosol 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with EIF5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF5 Gene

Pathways & Interactions for EIF5 Gene

genes like me logo Genes that share pathways with EIF5: view

Pathways by source for EIF5 Gene

1 Qiagen pathway for EIF5 Gene
1 Cell Signaling Technology pathway for EIF5 Gene
1 BioSystems pathway for EIF5 Gene

SIGNOR curated interactions for EIF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IDA 22156057
GO:0010467 gene expression TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with EIF5: view

Drugs & Compounds for EIF5 Gene

(4) Drugs for EIF5 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
arginine Nutra 346

(2) Additional Compounds for EIF5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gtp
Partial agonist, Agonist
retinoic acid
302-79-4
genes like me logo Genes that share compounds with EIF5: view

Transcripts for EIF5 Gene

Unigene Clusters for EIF5 Gene

Eukaryotic translation initiation factor 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3:
SP4:
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - -
SP11: - - - -
SP12: - -
SP13: - - - - - - - - -
SP14: -
SP15: -
SP16:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for EIF5 Gene

GeneLoc Exon Structure for
EIF5
ECgene alternative splicing isoforms for
EIF5

Expression for EIF5 Gene

mRNA expression in normal human tissues for EIF5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF5 Gene



SOURCE GeneReport for Unigene cluster for EIF5 Gene Hs.433702

genes like me logo Genes that share expression patterns with EIF5: view

Protein tissue co-expression partners for EIF5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF5 Gene

Orthologs for EIF5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF5 35
  • 93.01 (n)
  • 96.27 (a)
EIF5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF5 35
  • 93.18 (n)
  • 96.98 (a)
EIF5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif5 35
  • 92 (n)
  • 96.74 (a)
Eif5 16
Eif5 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF5 35
  • 99.61 (n)
  • 99.77 (a)
EIF5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif5 35
  • 92.46 (n)
  • 96.5 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF5 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF5 35
  • 86.56 (n)
  • 92.36 (a)
EIF5 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF5 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif5 35
  • 80.88 (n)
  • 85.06 (a)
Str.6939 35
zebrafish
(Danio rerio)
Actinopterygii eif5 35
  • 72.02 (n)
  • 75.91 (a)
wufb54h04 35
eif5 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6088 35
fruit fly
(Drosophila melanogaster)
Insecta eIF5 37
  • 50 (a)
eIF5 35
  • 58.25 (n)
  • 53.68 (a)
eIF5 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011203 35
  • 54.43 (n)
  • 53.91 (a)
worm
(Caenorhabditis elegans)
Secernentea C37C3.2a 37
  • 49 (a)
C37C3.2b 37
  • 44 (a)
C37C3.2 35
  • 54.8 (n)
  • 51.9 (a)
C37C3.2 36
  • 48 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER400C 35
  • 59.65 (n)
  • 60.53 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06095g 35
  • 54.47 (n)
  • 46.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF5 35
  • 51.68 (n)
  • 41.69 (a)
TIF5 36
  • 39 (a)
OneToOne
TIF5 38
barley
(Hordeum vulgare)
Liliopsida Hv.2257 35
rice
(Oryza sativa)
Liliopsida Os.8401 35
corn
(Zea mays)
Liliopsida Zm.97 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5403 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00366 35
  • 50 (n)
  • 42.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F7.05c 35
  • 52.78 (n)
  • 44.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8311 36
  • 56 (a)
OneToOne
Species with no ortholog for EIF5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF5 Gene

ENSEMBL:
Gene Tree for EIF5 (if available)
TreeFam:
Gene Tree for EIF5 (if available)

Paralogs for EIF5 Gene

Pseudogenes.org Pseudogenes for EIF5 Gene

genes like me logo Genes that share paralogs with EIF5: view

No data available for Paralogs for EIF5 Gene

Variants for EIF5 Gene

Sequence variations from dbSNP and Humsavar for EIF5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs373125881 -- 103,339,346(+) AAGTG(C/T)TCTGG intron-variant
rs372895277 -- 103,343,844(+) ATTTA(C/T)TTGAC utr-variant-3-prime
rs372833392 -- 103,340,649(+) TGGCA(-/G)GTTTG intron-variant
rs372776152 -- 103,344,093(+) GTCAT(C/T)TCTGT utr-variant-3-prime
rs372527871 -- 103,341,352(+) TTGGT(C/T)GTTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF5 Gene

Variant ID Type Subtype PubMed ID
nsv9168 CNV Loss 18304495
nsv902295 CNV Loss 21882294
nsv827067 CNV Gain 20364138

Variation tolerance for EIF5 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF5 Gene

HapMap Linkage Disequilibrium report
EIF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5 Gene

Disorders for EIF5 Gene

Relevant External Links for EIF5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF5
genes like me logo Genes that share disorders with EIF5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF5 Gene

Publications for EIF5 Gene

  1. Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. (PMID: 20092987) Yue Q.X. … Guo D.A. (Phytomedicine 2010) 23 67
  2. eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. (PMID: 20485439) Jennings M.D. … Pavitt G.D. (Nature 2010) 23 67
  3. eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation. (PMID: 19751744) Nanda J.S. … Lorsch J.R. (J. Mol. Biol. 2009) 23 67
  4. Positively selected disease response orthologous gene sets in the cereals identified using Sorghum bicolor L. Moench expression profiles and comparative genomics. (PMID: 19506000) Zamora A. … Kresovich S. (Mol. Biol. Evol. 2009) 23 67
  5. Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation. (PMID: 18639529) Rajesh K. … Ramaiah K.V. (Biochem. Biophys. Res. Commun. 2008) 23 67

Products for EIF5 Gene

Sources for EIF5 Gene

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