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EIF4G3 Gene

protein-coding   GIFtS: 67
GCID: GC01M021132

Eukaryotic Translation Initiation Factor 4 Gamma, 3

  Search for EIF4G3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 4 Gamma, 31 2     EIF-4G 32 3
eIF4GII2 3     EIF4G 32 3
EIF-4-Gamma 32 3     Eukaryotic Translation Initiation Factor 4 Gamma 32
EIF-4-Gamma II2 3     

External Ids:    HGNC: 32981   Entrez Gene: 86722   Ensembl: ENSG000000751517   OMIM: 6039295   UniProtKB: O434323   

Export aliases for EIF4G3 gene to outside databases

Previous GC identifers: GC01M020703 GC01M020168 GC01M020278 GC01M020602 GC01M020878 GC01M021005 GC01M019378


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF4G3 Gene:
EIF4G3 (eukaryotic translation initiation factor 4 gamma, 3) is a protein-coding gene. GO annotations related to this gene include RNA cap binding and translation initiation factor activity. An important paralog of this gene is EIF4G2.

UniProtKB/Swiss-Prot: IF4G3_HUMAN, O43432
Function: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap,
ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be
a functional homolog of EIF4G1

Gene Wiki entry for EIF4G3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF4G3 gene promoter:
         Nkx3-1   SRF   RP58   Nkx3-1 v4   AML1a   SRF (504 AA)   MyoD   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for EIF4G3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF4G3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

EIF4G3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4G3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M021132:  view genomic region     (about GC identifiers)

Start:
21,132,785 bp from pter      End:
21,503,381 bp from pter
Size:
370,597 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IF4G3_HUMAN, O43432 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 4 gamma 3  
Size: 1585 amino acids; 176652 Da
Subunit: Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit
complex, the composition of which varies with external and internal environmental conditions. It is composed of
at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine
kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to
phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin
stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing
EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring
about circularization of the mRNA (By similarity)
1 PDB 3D structure from and Proteopedia for EIF4G3:
1HU3 (3D)    
Secondary accessions: B9EGQ7 Q15597 Q5SWC3 Q8NEN1
Alternative splicing: 3 isoforms:  O43432-1   O43432-2   O43432-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EIF4G3: NX_O43432

Explore proteomics data for EIF4G3 at MOPED

Post-translational modifications: 

  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral
    protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA
    transcription1
  • Ubiquitination2 at Lys1069
  • Modification sites at PhosphoSitePlus

  • See EIF4G3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001185730.1  NP_001185731.1  NP_001185732.1  NP_003751.2  

    ENSEMBL proteins: 
     ENSP00000264211   ENSP00000473510   ENSP00000349386   ENSP00000395381   ENSP00000396083  
     ENSP00000383274   ENSP00000364071   ENSP00000364073   ENSP00000444693   ENSP00000442010  
     ENSP00000444401   ENSP00000364062  
    Reactome Protein details: O43432

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    Cloud-Clone Corp. Proteins for EIF4G3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR003890 MIF4G-like_typ-3
     IPR016021 MIF4-like_typ_1/2/3
     IPR003891 Initiation_fac_eIF4g_MI
     IPR003307 W2_domain
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O43432

    ProtoNet protein and cluster: O43432

    2 Blocks protein domains:
    IPB003307 eIF4-gamma/eIF5/eIF2-epsilon
    IPB003890 Initiation factor eIF-4 gamma


    UniProtKB/Swiss-Prot: IF4G3_HUMAN, O43432
    Similarity: Belongs to the eukaryotic initiation factor 4G family
    Similarity: Contains 5 HEAT repeats
    Similarity: Contains 1 MI domain
    Similarity: Contains 1 MIF4G domain
    Similarity: Contains 1 W2 domain


    Find genes that share domains with EIF4G3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF4G3_HUMAN, O43432
    Function: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap,
    ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be
    a functional homolog of EIF4G1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000339RNA cap binding TAS9418880
    GO:0003723RNA binding ----
    GO:0003743translation initiation factor activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with EIF4G3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EIF4G3:
     Increased cell number in G1, s 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Eif4g3):
     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with EIF4G3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF4G3
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    Block miRNA regulation of human, mouse, rat EIF4G3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF4G3 (see all 28):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-300 hsa-miR-517a hsa-miR-517c hsa-miR-378b hsa-miR-511 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidEIF4G3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016281eukaryotic translation initiation factor 4F complex TAS9418880

    Find genes that share ontologies with EIF4G3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF4G3 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF4F0.44
    3Translation Translation regulation by Alpha 1 adrenergic receptors
    Translation Translation regulation by Alpha 1 adrenergic receptors0.64
    4Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60
    5p70S6K Signaling
    mTOR Pathway0.54


    Find genes that share SuperPaths with EIF4G3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF4G3
        eIF2 Pathway
    mTOR Pathway
    Regulation of eIF4 and p70S6K
    Insulin Receptor Pathway

    3 GeneGo (Thomson Reuters) Pathways for EIF4G3
        Translation Insulin regulation of translation
    Translation Regulation of EIF4F activity
    Translation Translation regulation by Alpha-1 adrenergic receptors

    1 BioSystems Pathway for EIF4G3
        Translation Factors

    1 Reactome Pathway for EIF4G3
        ISG15 antiviral mechanism


    2 Kegg Pathways  (Kegg details for EIF4G3):
        RNA transport
    Viral myocarditis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF4G3
    Interactions:

        GeneGlobe Interaction Network for EIF4G3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF4G3 (O434322, 3 ENSP000002642114) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MKNK1Q9BUB52, 3, ENSP000003610144MINT-17051 MINT-8263148 I2D: score=4 STRING: ENSP00000361014
    PABPC1P119402, 3, ENSP000003130074MINT-15084 MINT-15083 I2D: score=4 STRING: ENSP00000313007
    CAMK1Q140123, ENSP000002564604I2D: score=2 STRING: ENSP00000256460
    EIF3HO153723, ENSP000002766824I2D: score=2 STRING: ENSP00000276682
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0006446regulation of translational initiation TAS9418880
    GO:0007283spermatogenesis IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with EIF4G3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF4G3 (IF4G3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF4G3 gene (4 alternative transcripts): 
    NM_001198801.1  NM_001198802.1  NM_001198803.1  NM_003760.4  

    Unigene Cluster for EIF4G3:

    Eukaryotic translation initiation factor 4 gamma, 3
    Hs.467084  [show with all ESTs]
    Unigene Representative Sequence: NM_001198801
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264211(uc010odi.2 uc010odj.2 uc009vpz.3 uc001bec.3)
    ENST00000602326 ENST00000435383 ENST00000496705 ENST00000374933 ENST00000485722
    ENST00000356916(uc001beg.3 uc010odk.2 uc001beh.3) ENST00000438975
    ENST00000411888 ENST00000476088 ENST00000463775 ENST00000400422(uc001bef.3 uc001bee.3)
    ENST00000374935 ENST00000374937 ENST00000536266 ENST00000537738 ENST00000544689
    ENST00000374927
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    hsa-miR-2052 hsa-miR-4307 hsa-miR-300 hsa-miR-517a hsa-miR-517c hsa-miR-378b hsa-miR-511 hsa-miR-374c
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    Additional mRNA sequence: 

    AB209119.1 AF012072.2 AK225489.1 AK294883.1 AK302087.1 AK302873.1 AK310195.1 BC030578.1 
    BC072413.1 BC094683.1 BC136643.1 BC144335.1 BX647897.1 Z34918.1 

    18 DOTS entries:

    DT.99973047  DT.446993  DT.100682647  DT.101973463  DT.121449040  DT.75113814  DT.75143879  DT.100660090 
    DT.95373783  DT.100817621  DT.121448922  DT.95373781  DT.95358735  DT.121448959  DT.86846346  DT.97800634 
    DT.121448903  DT.92437389 

    Selected AceView cDNA sequences (see all 268):

    AI989287 AA191463 AA293841 AA113265 BF057034 BQ721592 BM787716 CF780803 
    BP338006 AA490854 AA903329 BE670847 AW341682 BQ433783 AA134568 CD171863 
    AA665666 AI567339 BU193092 AW241316 AL040811 BE466545 BU620826 N66282 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                  -     -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                          
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for EIF4G3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF4G3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTTTTAA
    EIF4G3 Expression
    About this image


    EIF4G3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
    EIF4G3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF4G3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467084
        Custom PCR Arrays for EIF4G3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EIF4G3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif4g31 , 5 eukaryotic translation initiation factor 4 gamma, 31, 5 85.77(n)1
    87.16(a)1
      4 (70.02 cM)5
    2308611  NM_172703.31  NP_766291.21 
     1379930225 
    chicken
    (Gallus gallus)
    Aves EIF4G31 eukaryotic translation initiation factor 4 gamma, 3 77.55(n)
    79.62(a)
      425544  XM_004947540.1  XP_004947597.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF4G36
    eukaryotic translation initiation factor 4 gamma, ...
    72(a)
    1 ↔ 1
    GL343609.1(27358-59904)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208312 Xenopus laevis transcribed sequence with weak similarity more 84.11(n)    BQ884389.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.204892 Transcribed sequence with moderate similarity to protein more 83.11(n)    AW154022.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101923 translational initiation translation
    initiation more
    36(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea ifg-16
    Protein IFG-1, isoform a
    20(a)
    1 → many
    II(8217231-8222201) WBGene00002066
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF4632(YGL049C)4 Translation initiation factor eIF4G, subunit of the more   --   7(409604-406860) 852833  NP_011466.1 


    ENSEMBL Gene Tree for EIF4G3 (if available)
    TreeFam Gene Tree for EIF4G3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF4G3 gene
    EIF4G22  EIF4G12  
    3 SIMAP similar genes for EIF4G3 using alignment to 10 protein entries:     IF4G3_HUMAN (see all proteins):
    EIF4G1    EIF4G1 variant protein    EIF4G2

    Find genes that share paralogs with EIF4G3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF4G3 (see all 6806)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787762641,2
    C--21132381(+) TGGAGC/TTGGCA 3 -- ds50010--------
    rs1464707961,2
    --21132418(+) TGGCTC/TGATTT 3 -- ds50010--------
    rs2000399641,2
    C--21132419(+) GGCTTG/TATTTT 3 -- ds50010--------
    rs125655041,2
    C,F,H--21132575(+) AGTGGC/TAGTCT 3 -- ds500116Minor allele frequency- T:0.06NS EA NA 1846
    rs1852888461,2
    --21132685(+) TAGTGC/TTGGAA 3 -- ds50010--------
    rs341265131,2
    C,F--21132778(+) GTGAGT/AAGAGA 3 -- ds50014Minor allele frequency- A:0.08NA 126
    rs1409061031,2
    --21132850(+) TCACTC/GTCTCT 3 -- ut310--------
    rs1445696141,2
    C--21132856(+) TCTCTC/TGTTTT 3 -- ut310--------
    rs745228451,2
    C,F--21133215(+) ATGTAT/CGTTTT 3 -- ut311Minor allele frequency- C:0.07EA 120
    rs2003240021,2
    C--21133497(+) TCAAC-/TTTTTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for EIF4G3 (21132785 - 21382785 bp, first 250kb of EIF4G3)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for EIF4G3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1356855CNV Deletion17803354
    esv2675549CNV Deletion23128226
    esv2745031CNV Deletion23290073
    esv2669682CNV Deletion23128226
    esv2672607CNV Deletion23128226
    esv1007787CNV Insertion20482838
    nsv160811CNV Loss16902084
    nsv871858CNV Loss21882294
    nsv870827CNV Gain21882294
    nsv834380CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF4G3
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF4G3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603929    OMIM disorders: --


    Find genes that share disorders with EIF4G3           About GenesLikeMe

    Genetic Association Database (GAD): EIF4G3
    Human Genome Epidemiology (HuGE) Navigator: EIF4G3 (1 document)

    Export disorders for EIF4G3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF4G3 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with EIF4G3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel functional human eukaryotic translation initiation factor 4G. (PubMed id 9418880)1, 2, 3, 9 Gradi A....Sonenberg N. (Mol. Cell. Biol. 1998)
    2. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PubMed id 14507913)1, 2, 9 Qin H.... Edelman A.M. (J. Biol. Chem. 2003)
    3. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L- protease cleavage site in vitro. (PubMed id 15016848)1, 2, 9 Gradi A....Belsham G.J. (J. Virol. 2004)
    4. Human rhin4ovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. (PubMed id 12663812)1, 2, 9 Gradi A.... Sonenberg N. (J. Virol. 2003)
    5. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. (PubMed id 9857202)1, 2, 9 Imataka H.... Sonenberg N. (EMBO J. 1998)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII. (PubMed id 12975586)1, 2 Miura T.... Shimma N. (J. Biomol. NMR 2003)
    10. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. (PubMed id 11172724)1, 2 Marcotrigiano J.... Burley S.K. (Mol. Cell 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8672 HGNC: 3298 AceView: EIF4G3 Ensembl:ENSG00000075151 euGenes: HUgn8672
    ECgene: EIF4G3 Kegg: 8672 H-InvDB: EIF4G3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF4G3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF4G3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EIF4G3 gene:
    Search GeneIP for patents involving EIF4G3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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