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Aliases for EIF4G3 Gene

Aliases for EIF4G3 Gene

  • Eukaryotic Translation Initiation Factor 4 Gamma, 3 2 3
  • EIF-4-Gamma II 3 4
  • EIF-4-Gamma 3 3 4
  • EIF-4G 3 3 4
  • EIF4G 3 3 4
  • EIF4GII 3 4
  • Eukaryotic Translation Initiation Factor 4 Gamma 3 3

External Ids for EIF4G3 Gene

Previous GeneCards Identifiers for EIF4G3 Gene

  • GC01M020703
  • GC01M020168
  • GC01M020278
  • GC01M020602
  • GC01M021005
  • GC01M021132
  • GC01M019378

Summaries for EIF4G3 Gene

GeneCards Summary for EIF4G3 Gene

EIF4G3 (Eukaryotic Translation Initiation Factor 4 Gamma, 3) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and p70S6K Signaling. GO annotations related to this gene include translation initiation factor activity and RNA cap binding. An important paralog of this gene is EIF4G1.

UniProtKB/Swiss-Prot for EIF4G3 Gene

  • Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Gene Wiki entry for EIF4G3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4G3 Gene

Genomics for EIF4G3 Gene

Regulatory Elements for EIF4G3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF4G3 Gene

Start:
20,806,292 bp from pter
End:
21,176,888 bp from pter
Size:
370,597 bases
Orientation:
Minus strand

Genomic View for EIF4G3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF4G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4G3 Gene

Proteins for EIF4G3 Gene

  • Protein details for EIF4G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43432-IF4G3_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 3
    Protein Accession:
    O43432
    Secondary Accessions:
    • B9EGQ7
    • Q15597
    • Q504Z1
    • Q5SWC3
    • Q8NEN1

    Protein attributes for EIF4G3 Gene

    Size:
    1585 amino acids
    Molecular mass:
    176652 Da
    Quaternary structure:
    • Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity).

    Three dimensional structures from OCA and Proteopedia for EIF4G3 Gene

    Alternative splice isoforms for EIF4G3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4G3 Gene

Proteomics data for EIF4G3 Gene at MOPED

Post-translational modifications for EIF4G3 Gene

  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
  • Ubiquitination at Lys1069
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF4G3 Gene

No data available for DME Specific Peptides for EIF4G3 Gene

Domains for EIF4G3 Gene

Suggested Antigen Peptide Sequences for EIF4G3 Gene

Graphical View of Domain Structure for InterPro Entry

O43432

UniProtKB/Swiss-Prot:

IF4G3_HUMAN :
  • O43432
Domain:
  • Contains 1 MI domain.
  • Contains 1 MIF4G domain.
  • Contains 1 W2 domain.
Family:
  • Belongs to the eukaryotic initiation factor 4G family.
Similarity:
  • Contains 5 HEAT repeats.
genes like me logo Genes that share domains with EIF4G3: view

No data available for Gene Families for EIF4G3 Gene

Function for EIF4G3 Gene

Molecular function for EIF4G3 Gene

UniProtKB/Swiss-Prot Function: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Gene Ontology (GO) - Molecular Function for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 9418880
GO:0003723 RNA binding --
GO:0003743 translation initiation factor activity IEA --
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with EIF4G3: view

Phenotypes for EIF4G3 Gene

genes like me logo Genes that share phenotypes with EIF4G3: view

Animal Model Products

CRISPR Products

miRNA for EIF4G3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF4G3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF4G3 Gene

Localization for EIF4G3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4G3 Gene COMPARTMENTS Subcellular localization image for EIF4G3 gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 9418880
genes like me logo Genes that share ontologies with EIF4G3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4G3 Gene

Pathways for EIF4G3 Gene

genes like me logo Genes that share pathways with EIF4G3: view

Interacting Proteins for EIF4G3 Gene

Gene Ontology (GO) - Biological Process for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation --
GO:0006413 translational initiation IEA --
GO:0006446 regulation of translational initiation TAS 9418880
GO:0007283 spermatogenesis --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with EIF4G3: view

Transcripts for EIF4G3 Gene

Unigene Clusters for EIF4G3 Gene

Eukaryotic translation initiation factor 4 gamma, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF4G3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EIF4G3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2:
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:

Relevant External Links for EIF4G3 Gene

GeneLoc Exon Structure for
EIF4G3
ECgene alternative splicing isoforms for
EIF4G3

Expression for EIF4G3 Gene

mRNA expression in normal human tissues for EIF4G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for EIF4G3 Gene

SOURCE GeneReport for Unigene cluster for EIF4G3 Gene Hs.467084

genes like me logo Genes that share expressions with EIF4G3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4G3 Gene

Orthologs for EIF4G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4G3 35
  • 99.66 (n)
  • 99.62 (a)
EIF4G3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4G3 35
  • 92.08 (n)
  • 92.68 (a)
EIF4G3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4G3 35
  • 92.79 (n)
  • 93.22 (a)
EIF4G3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4g3 35
  • 85.77 (n)
  • 87.16 (a)
Eif4g3 16
Eif4g3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF4G3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif4g3 35
  • 85.83 (n)
  • 87.68 (a)
chicken
(Gallus gallus)
Aves EIF4G3 35
  • 77.55 (n)
  • 79.62 (a)
EIF4G3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4G3 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20831 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216088 35
  • 68.4 (n)
  • 71.82 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4652 35
zebrafish
(Danio rerio)
Actinopterygii Dr.20489 35
EIF4G3 (2 of 2) 36
  • 55 (a)
OneToMany
eif4g3b 35
  • 64.68 (n)
  • 64.79 (a)
eif4g3b 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF4G 36
  • 21 (a)
ManyToMany
eIF4G2 36
  • 15 (a)
ManyToMany
CG10192 37
  • 36 (a)
eIF-4G 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea ifg-1 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF4631 36
  • 20 (a)
ManyToMany
TIF4632 36
  • 20 (a)
ManyToMany
TIF4632 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for EIF4G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4G3 Gene

ENSEMBL:
Gene Tree for EIF4G3 (if available)
TreeFam:
Gene Tree for EIF4G3 (if available)

Paralogs for EIF4G3 Gene

Paralogs for EIF4G3 Gene

genes like me logo Genes that share paralogs with EIF4G3: view

Variants for EIF4G3 Gene

Sequence variations from dbSNP and Humsavar for EIF4G3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs885363 -- 20,998,867(-) TTTTT(G/T)CTCCT intron-variant
rs906254 -- 20,998,267(-) TTAAC(C/T)GCATT intron-variant
rs906255 -- 20,997,759(-) TGTGT(C/T)GTTTT intron-variant
rs925036 -- 21,037,349(+) TTTAG(A/G)GGCTT intron-variant
rs935917 -- 20,840,609(+) TTACA(A/T)CATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4G3 Gene

Variant ID Type Subtype PubMed ID
nsv870827 CNV Gain 21882294
nsv871858 CNV Loss 21882294
esv1356855 CNV Deletion 17803354
esv2669682 CNV Deletion 23128226
esv2745031 CNV Deletion 23290073
esv2675549 CNV Deletion 23128226
esv2672607 CNV Deletion 23128226
nsv834380 CNV Gain 17160897
nsv160811 CNV Loss 16902084
esv1007787 CNV Insertion 20482838

Relevant External Links for EIF4G3 Gene

HapMap Linkage Disequilibrium report
EIF4G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4G3 Gene

Disorders for EIF4G3 Gene

Relevant External Links for EIF4G3

Genetic Association Database (GAD)
EIF4G3
Human Genome Epidemiology (HuGE) Navigator
EIF4G3
genes like me logo Genes that share disorders with EIF4G3: view

No data available for UniProtKB/Swiss-Prot for EIF4G3 Gene

Publications for EIF4G3 Gene

  1. A novel functional human eukaryotic translation initiation factor 4G. (PMID: 9418880) Gradi A. … Sonenberg N. (Mol. Cell. Biol. 1998) 2 3 4 23
  2. Human rhin4ovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. (PMID: 12663812) Gradi A. … Sonenberg N. (J. Virol. 2003) 3 4 23
  3. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PMID: 14507913) Qin H. … Edelman A.M. (J. Biol. Chem. 2003) 3 4 23
  4. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. (PMID: 9857202) Imataka H. … Sonenberg N. (EMBO J. 1998) 3 4 23
  5. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L- protease cleavage site in vitro. (PMID: 15016848) Gradi A. … Belsham G.J. (J. Virol. 2004) 3 4 23

Products for EIF4G3 Gene

Sources for EIF4G3 Gene

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