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Aliases for EIF4G3 Gene

Aliases for EIF4G3 Gene

  • Eukaryotic Translation Initiation Factor 4 Gamma 3 2 3 5
  • EIF-4-Gamma II 3 4
  • EIF-4-Gamma 3 3 4
  • EIF-4G 3 3 4
  • EIF4G 3 3 4
  • EIF4GII 3 4
  • Eukaryotic Translation Initiation Factor 4 Gamma, 3 2

External Ids for EIF4G3 Gene

Previous GeneCards Identifiers for EIF4G3 Gene

  • GC01M020703
  • GC01M020168
  • GC01M020278
  • GC01M020602
  • GC01M021005
  • GC01M021132
  • GC01M019378

Summaries for EIF4G3 Gene

Entrez Gene Summary for EIF4G3 Gene

  • The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

GeneCards Summary for EIF4G3 Gene

EIF4G3 (Eukaryotic Translation Initiation Factor 4 Gamma 3) is a Protein Coding gene. Diseases associated with EIF4G3 include Mouth Disease. Among its related pathways are Interferon gamma signaling and Translation Insulin regulation of translation. GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is EIF4G1.

UniProtKB/Swiss-Prot for EIF4G3 Gene

  • Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Gene Wiki entry for EIF4G3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4G3 Gene

Genomics for EIF4G3 Gene

Regulatory Elements for EIF4G3 Gene

Enhancers for EIF4G3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F020884 0.4 ENCODE 29.2 +292.9 292871 0.6 CEBPA CEBPB PRDM1 EIF4G3 ENSG00000233069 SH2D5 LOC105376830 RNU7-200P
GH01F021259 0.9 FANTOM5 Ensembl ENCODE 21.7 -84.6 -84606 4.8 PKNOX1 ARID4B FOS KLF13 MCM3 NFYC MXD4 REST KAT8 MEF2D EIF4G3 NBPF2P MUL1 ECE1 ALPL ENSG00000236936 PIR51422
GH01F021148 1.4 FANTOM5 Ensembl ENCODE 15.3 +26.4 26409 4.6 INSM2 KLF17 ZNF2 ZEB1 ZNF121 ZNF366 SCRT2 FOS KLF7 ZNF391 EIF4G3 MIR1256 HP1BP3 HSPE1P27 GC01M021094
GH01F021254 0.2 ENCODE 13.8 -78.0 -77954 2.5 TBL1XR1 KLF17 ARID4B ZNF48 ZNF2 RAD21 ZNF366 SCRT2 ZNF143 DEK EIF4G3 ENSG00000236936 PIR51422
GH01F021250 0.9 Ensembl ENCODE 13.5 -74.5 -74527 3.5 ATF1 MLX ARID4B YY1 FOS NFYC PPARG KAT8 SREBF1 MBD2 EIF4G3 ENSG00000236936 PIR51422
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EIF4G3 on UCSC Golden Path with GeneCards custom track

Promoters for EIF4G3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000280026 1320 3201 HDGF PKNOX1 ARNT ARID4B DMAP1 YY1 ZNF263 REST KAT8 SSRP1

Genomic Location for EIF4G3 Gene

Chromosome:
1
Start:
20,806,292 bp from pter
End:
21,177,320 bp from pter
Size:
371,029 bases
Orientation:
Minus strand

Genomic View for EIF4G3 Gene

Genes around EIF4G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4G3 Gene

Proteins for EIF4G3 Gene

  • Protein details for EIF4G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43432-IF4G3_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 3
    Protein Accession:
    O43432
    Secondary Accessions:
    • B9EGQ7
    • Q15597
    • Q504Z1
    • Q5SWC3
    • Q8NEN1

    Protein attributes for EIF4G3 Gene

    Size:
    1585 amino acids
    Molecular mass:
    176652 Da
    Quaternary structure:
    • Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity).

    Three dimensional structures from OCA and Proteopedia for EIF4G3 Gene

    Alternative splice isoforms for EIF4G3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4G3 Gene

Post-translational modifications for EIF4G3 Gene

  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
  • Ubiquitination at Lys 1069
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4G3 Gene

Domains & Families for EIF4G3 Gene

Suggested Antigen Peptide Sequences for EIF4G3 Gene

Graphical View of Domain Structure for InterPro Entry

O43432

UniProtKB/Swiss-Prot:

IF4G3_HUMAN :
  • Contains 1 MI domain.
  • Belongs to the eukaryotic initiation factor 4G family.
  • Contains 5 HEAT repeats.
Domain:
  • Contains 1 MI domain.
  • Contains 1 MIF4G domain.
  • Contains 1 W2 domain.
Family:
  • Belongs to the eukaryotic initiation factor 4G family.
Similarity:
  • Contains 5 HEAT repeats.
genes like me logo Genes that share domains with EIF4G3: view

No data available for Gene Families for EIF4G3 Gene

Function for EIF4G3 Gene

Molecular function for EIF4G3 Gene

UniProtKB/Swiss-Prot Function:
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Gene Ontology (GO) - Molecular Function for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 9418880
GO:0003723 RNA binding IEA --
GO:0003743 translation initiation factor activity IEA --
GO:0008135 translation factor activity, RNA binding TAS 9418880
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with EIF4G3: view
genes like me logo Genes that share phenotypes with EIF4G3: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4G3 Gene

Localization for EIF4G3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4G3 Gene COMPARTMENTS Subcellular localization image for EIF4G3 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 9418880
genes like me logo Genes that share ontologies with EIF4G3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4G3 Gene

Pathways & Interactions for EIF4G3 Gene

genes like me logo Genes that share pathways with EIF4G3: view

SIGNOR curated interactions for EIF4G3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
GO:0006446 regulation of translational initiation TAS 9418880
GO:0010507 NOT negative regulation of autophagy IMP 18426977
genes like me logo Genes that share ontologies with EIF4G3: view

Drugs & Compounds for EIF4G3 Gene

(2) Drugs for EIF4G3 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0
4EGI-1 Pharma Competitive eIF4E/eIF4G interaction inhibitor 0

(2) ApexBio Compounds for EIF4G3 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4G3: view

Transcripts for EIF4G3 Gene

Unigene Clusters for EIF4G3 Gene

Eukaryotic translation initiation factor 4 gamma, 3:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2:
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:

Relevant External Links for EIF4G3 Gene

GeneLoc Exon Structure for
EIF4G3
ECgene alternative splicing isoforms for
EIF4G3

Expression for EIF4G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF4G3 Gene

This gene is overexpressed in Urine (25.9), Adrenal (15.9), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4G3 Gene



Protein tissue co-expression partners for EIF4G3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4G3 Gene:

EIF4G3

SOURCE GeneReport for Unigene cluster for EIF4G3 Gene:

Hs.467084
genes like me logo Genes that share expression patterns with EIF4G3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4G3 Gene

Orthologs for EIF4G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4G3 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia EIF4G3 34 35
  • 92.79 (n)
cow
(Bos Taurus)
Mammalia EIF4G3 34 35
  • 92.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif4g3 34
  • 85.83 (n)
mouse
(Mus musculus)
Mammalia Eif4g3 34 16 35
  • 85.77 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF4G3 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4G3 34 35
  • 77.55 (n)
lizard
(Anolis carolinensis)
Reptilia EIF4G3 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216088 34
  • 68.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20831 34
zebrafish
(Danio rerio)
Actinopterygii eif4g3b 34 35
  • 64.68 (n)
EIF4G3 (2 of 2) 35
  • 55 (a)
OneToMany
Dr.20489 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4652 34
fruit fly
(Drosophila melanogaster)
Insecta CG10192 36
  • 36 (a)
eIF-4G 36
  • 31 (a)
eIF4G 35
  • 21 (a)
ManyToMany
eIF4G2 35
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ifg-1 35
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF4631 35
  • 20 (a)
ManyToMany
TIF4632 35 37
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
Species where no ortholog for EIF4G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4G3 Gene

ENSEMBL:
Gene Tree for EIF4G3 (if available)
TreeFam:
Gene Tree for EIF4G3 (if available)

Paralogs for EIF4G3 Gene

Paralogs for EIF4G3 Gene

genes like me logo Genes that share paralogs with EIF4G3: view

Variants for EIF4G3 Gene

Sequence variations from dbSNP and Humsavar for EIF4G3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193921047 Uncertain significance 20,865,175(-) AAAAA(G/T)ATAAA downstream-variant-500B, reference, missense
rs10127757 -- 21,163,552(+) GATAC(A/G)ATCTT intron-variant
rs10127916 -- 21,163,667(+) CCTAA(A/G)GGTAA intron-variant
rs10157616 -- 20,918,089(+) AATAT(C/T)CCTCT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs10218584 -- 21,147,987(+) CACCT(C/G)TTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4G3 Gene

Variant ID Type Subtype PubMed ID
esv1007787 CNV insertion 20482838
esv1356855 CNV deletion 17803354
esv2669682 CNV deletion 23128226
esv2672607 CNV deletion 23128226
esv2675549 CNV deletion 23128226
esv3387129 CNV insertion 20981092
esv3555121 CNV deletion 23714750
esv3585432 CNV loss 21293372
esv3585433 CNV loss 21293372
esv3585434 CNV loss 21293372
esv3585436 CNV loss 21293372
esv3585437 CNV loss 21293372
esv3585439 CNV loss 21293372
nsv1009855 CNV loss 25217958
nsv1012238 CNV loss 25217958
nsv1075300 CNV deletion 25765185
nsv1114945 CNV deletion 24896259
nsv1125320 OTHER inversion 24896259
nsv1133821 CNV deletion 24896259
nsv1136066 CNV deletion 24896259
nsv1151121 CNV deletion 26484159
nsv160811 CNV deletion 16902084
nsv474786 CNV novel sequence insertion 20440878
nsv834380 CNV gain 17160897

Variation tolerance for EIF4G3 Gene

Residual Variation Intolerance Score: 5.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4G3 Gene

Disorders for EIF4G3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF4G3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mouth disease
  • mouth disorders
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EIF4G3

Genetic Association Database (GAD)
EIF4G3
Human Genome Epidemiology (HuGE) Navigator
EIF4G3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4G3
genes like me logo Genes that share disorders with EIF4G3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4G3 Gene

Publications for EIF4G3 Gene

  1. A novel functional human eukaryotic translation initiation factor 4G. (PMID: 9418880) Gradi A. … Sonenberg N. (Mol. Cell. Biol. 1998) 2 3 4 22 64
  2. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L- protease cleavage site in vitro. (PMID: 15016848) Gradi A. … Belsham G.J. (J. Virol. 2004) 3 4 22 64
  3. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PMID: 14507913) Qin H. … Edelman A.M. (J. Biol. Chem. 2003) 3 4 22 64
  4. Human rhin4ovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. (PMID: 12663812) Gradi A. … Sonenberg N. (J. Virol. 2003) 3 4 22 64
  5. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. (PMID: 9857202) Imataka H. … Sonenberg N. (EMBO J. 1998) 3 4 22 64

Products for EIF4G3 Gene

Sources for EIF4G3 Gene

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