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Aliases for EIF4G3 Gene

Aliases for EIF4G3 Gene

  • Eukaryotic Translation Initiation Factor 4 Gamma 3 2 3
  • Eukaryotic Translation Initiation Factor 4 Gamma, 3 2 3 5
  • EIF-4-Gamma II 3 4
  • EIF-4-Gamma 3 3 4
  • EIF-4G 3 3 4
  • EIF4G 3 3 4
  • EIF4GII 3 4

External Ids for EIF4G3 Gene

Previous GeneCards Identifiers for EIF4G3 Gene

  • GC01M020703
  • GC01M020168
  • GC01M020278
  • GC01M020602
  • GC01M021005
  • GC01M021132
  • GC01M019378

Summaries for EIF4G3 Gene

GeneCards Summary for EIF4G3 Gene

EIF4G3 (Eukaryotic Translation Initiation Factor 4 Gamma 3) is a Protein Coding gene. Diseases associated with EIF4G3 include mouth disease. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is EIF4G1.

UniProtKB/Swiss-Prot for EIF4G3 Gene

  • Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Gene Wiki entry for EIF4G3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4G3 Gene

Genomics for EIF4G3 Gene

Regulatory Elements for EIF4G3 Gene

Promoters for EIF4G3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF4G3 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF4G3 Gene

Chromosome:
1
Start:
20,806,292 bp from pter
End:
21,177,320 bp from pter
Size:
371,029 bases
Orientation:
Minus strand

Genomic View for EIF4G3 Gene

Genes around EIF4G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4G3 Gene

Proteins for EIF4G3 Gene

  • Protein details for EIF4G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43432-IF4G3_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 3
    Protein Accession:
    O43432
    Secondary Accessions:
    • B9EGQ7
    • Q15597
    • Q504Z1
    • Q5SWC3
    • Q8NEN1

    Protein attributes for EIF4G3 Gene

    Size:
    1585 amino acids
    Molecular mass:
    176652 Da
    Quaternary structure:
    • Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity).

    Three dimensional structures from OCA and Proteopedia for EIF4G3 Gene

    Alternative splice isoforms for EIF4G3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4G3 Gene

Proteomics data for EIF4G3 Gene at MOPED

Post-translational modifications for EIF4G3 Gene

  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
  • Ubiquitination at Lys 1069
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for EIF4G3 Gene

Domains & Families for EIF4G3 Gene

Suggested Antigen Peptide Sequences for EIF4G3 Gene

Graphical View of Domain Structure for InterPro Entry

O43432

UniProtKB/Swiss-Prot:

IF4G3_HUMAN :
  • Contains 1 MI domain.
  • Belongs to the eukaryotic initiation factor 4G family.
  • Contains 5 HEAT repeats.
Domain:
  • Contains 1 MI domain.
  • Contains 1 MIF4G domain.
  • Contains 1 W2 domain.
Family:
  • Belongs to the eukaryotic initiation factor 4G family.
Similarity:
  • Contains 5 HEAT repeats.
genes like me logo Genes that share domains with EIF4G3: view

No data available for Gene Families for EIF4G3 Gene

Function for EIF4G3 Gene

Molecular function for EIF4G3 Gene

UniProtKB/Swiss-Prot Function:
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Gene Ontology (GO) - Molecular Function for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 9418880
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IEA --
GO:0008135 translation factor activity, RNA binding TAS 9418880
genes like me logo Genes that share ontologies with EIF4G3: view
genes like me logo Genes that share phenotypes with EIF4G3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4G3 Gene

Localization for EIF4G3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4G3 Gene COMPARTMENTS Subcellular localization image for EIF4G3 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EIF4G3 Gene

Pathways & Interactions for EIF4G3 Gene

genes like me logo Genes that share pathways with EIF4G3: view

SIGNOR curated interactions for EIF4G3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with EIF4G3: view

Drugs & Compounds for EIF4G3 Gene

(2) Drugs for EIF4G3 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0
4EGI-1 Pharma Competitive eIF4E/eIF4G interaction inhibitor 0
genes like me logo Genes that share compounds with EIF4G3: view

Transcripts for EIF4G3 Gene

Unigene Clusters for EIF4G3 Gene

Eukaryotic translation initiation factor 4 gamma, 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2:
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:

Relevant External Links for EIF4G3 Gene

GeneLoc Exon Structure for
EIF4G3
ECgene alternative splicing isoforms for
EIF4G3

Expression for EIF4G3 Gene

mRNA expression in normal human tissues for EIF4G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF4G3 Gene

This gene is overexpressed in Urine (25.9), Adrenal (15.9), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for EIF4G3 Gene



SOURCE GeneReport for Unigene cluster for EIF4G3 Gene Hs.467084

genes like me logo Genes that share expression patterns with EIF4G3: view

Protein tissue co-expression partners for EIF4G3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4G3 Gene

Orthologs for EIF4G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4G3 35
  • 99.66 (n)
  • 99.62 (a)
EIF4G3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4G3 36
  • 92 (a)
OneToOne
EIF4G3 35
  • 92.08 (n)
  • 92.68 (a)
dog
(Canis familiaris)
Mammalia EIF4G3 35
  • 92.79 (n)
  • 93.22 (a)
EIF4G3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4g3 36
  • 86 (a)
OneToOne
Eif4g3 16
Eif4g3 35
  • 85.77 (n)
  • 87.16 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF4G3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif4g3 35
  • 85.83 (n)
  • 87.68 (a)
chicken
(Gallus gallus)
Aves EIF4G3 36
  • 79 (a)
OneToOne
EIF4G3 35
  • 77.55 (n)
  • 79.62 (a)
lizard
(Anolis carolinensis)
Reptilia EIF4G3 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20831 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216088 35
  • 68.4 (n)
  • 71.82 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4652 35
zebrafish
(Danio rerio)
Actinopterygii EIF4G3 (2 of 2) 36
  • 55 (a)
OneToMany
eif4g3b 36
  • 55 (a)
OneToMany
Dr.20489 35
eif4g3b 35
  • 64.68 (n)
  • 64.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10192 37
  • 36 (a)
eIF-4G 37
  • 31 (a)
eIF4G 36
  • 21 (a)
ManyToMany
eIF4G2 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ifg-1 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF4631 36
  • 20 (a)
ManyToMany
TIF4632 36
  • 20 (a)
ManyToMany
TIF4632 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for EIF4G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4G3 Gene

ENSEMBL:
Gene Tree for EIF4G3 (if available)
TreeFam:
Gene Tree for EIF4G3 (if available)

Paralogs for EIF4G3 Gene

Paralogs for EIF4G3 Gene

genes like me logo Genes that share paralogs with EIF4G3: view

Variants for EIF4G3 Gene

Sequence variations from dbSNP and Humsavar for EIF4G3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35176330 - 20,941,500(+) GACAG(C/G)GCTCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs35731992 - 20,941,853(+) CTTCC(C/T)GTTTT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs2230572 - 20,851,307(-) GTGGA(A/T)GTGGA reference, missense
rs885363 -- 20,998,867(-) TTTTT(G/T)CTCCT intron-variant
rs906254 -- 20,998,267(-) TTAAC(C/T)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4G3 Gene

Variant ID Type Subtype PubMed ID
nsv870827 CNV Gain 21882294
nsv871858 CNV Loss 21882294
esv1356855 CNV Deletion 17803354
esv2669682 CNV Deletion 23128226
esv2745031 CNV Deletion 23290073
esv2675549 CNV Deletion 23128226
esv2672607 CNV Deletion 23128226
nsv834380 CNV Gain 17160897
nsv160811 CNV Loss 16902084
esv1007787 CNV Insertion 20482838

Variation tolerance for EIF4G3 Gene

Residual Variation Intolerance Score: 5.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4G3 Gene

HapMap Linkage Disequilibrium report
EIF4G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4G3 Gene

Disorders for EIF4G3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF4G3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mouth disease
  • mouth diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EIF4G3

Genetic Association Database (GAD)
EIF4G3
Human Genome Epidemiology (HuGE) Navigator
EIF4G3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4G3
genes like me logo Genes that share disorders with EIF4G3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4G3 Gene

Publications for EIF4G3 Gene

  1. A novel functional human eukaryotic translation initiation factor 4G. (PMID: 9418880) Gradi A. … Sonenberg N. (Mol. Cell. Biol. 1998) 2 3 4 23 67
  2. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L- protease cleavage site in vitro. (PMID: 15016848) Gradi A. … Belsham G.J. (J. Virol. 2004) 3 23
  3. Human rhin4ovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. (PMID: 12663812) Gradi A. … Sonenberg N. (J. Virol. 2003) 3 23
  4. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PMID: 14507913) Qin H. … Edelman A.M. (J. Biol. Chem. 2003) 3 23
  5. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. (PMID: 9857202) Imataka H. … Sonenberg N. (EMBO J. 1998) 3 23

Products for EIF4G3 Gene

Sources for EIF4G3 Gene

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