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Aliases for EIF4G2 Gene

Aliases for EIF4G2 Gene

  • Eukaryotic Translation Initiation Factor 4 Gamma 2 2 3
  • Eukaryotic Translation Initiation Factor 4 Gamma, 2 2 3 5
  • Death-Associated Protein 5 3 4
  • EIF-4-Gamma 2 3 4
  • EIF-4G 2 3 4
  • EIF4G 2 3 4
  • DAP-5 3 4
  • DAP5 3 4
  • P97 3 4
  • Eukaryotic Translation Initiation Factor 4G-Like 1 3
  • Aging-Associated Protein 1 3
  • AAG1 3
  • NAT1 3

External Ids for EIF4G2 Gene

Previous GeneCards Identifiers for EIF4G2 Gene

  • GC11M011830
  • GC11M011388
  • GC11M010857
  • GC11M010782
  • GC11M010509

Summaries for EIF4G2 Gene

Entrez Gene Summary for EIF4G2 Gene

  • Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for EIF4G2 Gene

EIF4G2 (Eukaryotic Translation Initiation Factor 4 Gamma 2) is a Protein Coding gene. Among its related pathways are Allograft rejection and Immune System. GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is EIF4G1.

UniProtKB/Swiss-Prot for EIF4G2 Gene

  • Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.

Gene Wiki entry for EIF4G2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4G2 Gene

Genomics for EIF4G2 Gene

Regulatory Elements for EIF4G2 Gene

Enhancers for EIF4G2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF4G2 on UCSC Golden Path with GeneCards custom track

Promoters for EIF4G2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF4G2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF4G2 Gene

Chromosome:
11
Start:
10,797,046 bp from pter
End:
10,809,110 bp from pter
Size:
12,065 bases
Orientation:
Minus strand

Genomic View for EIF4G2 Gene

Genes around EIF4G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4G2 Gene

Proteins for EIF4G2 Gene

  • Protein details for EIF4G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78344-IF4G2_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 2
    Protein Accession:
    P78344
    Secondary Accessions:
    • O60877
    • P78404
    • Q0VH00
    • Q0VH01
    • Q2NKW9
    • Q49A79
    • Q53EU1
    • Q58EZ2
    • Q8NI71
    • Q96C16

    Protein attributes for EIF4G2 Gene

    Size:
    907 amino acids
    Molecular mass:
    102362 Da
    Quaternary structure:
    • Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD.
    Miscellaneous:
    • This gene has been shown to be extensively edited in the liver of APOBEC1 transgenic animal model. Its aberrant editing could contribute to the potent oncogenesis induced by overexpression of APOBEC1. The aberrant edited sequence, called NAT1, is likely to be a fundamental translational repressor.
    SequenceCaution:
    • Sequence=BAB93515.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD97268.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical GTG valine codon.; Evidence={ECO:0000305}; Sequence=CAA61857.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical GTG valine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF4G2 Gene

    Alternative splice isoforms for EIF4G2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4G2 Gene

Proteomics data for EIF4G2 Gene at MOPED

Post-translational modifications for EIF4G2 Gene

  • Phosphorylation; hyperphosphorylated during mitosis.
  • Ubiquitination at Lys 158, Lys 170, Lys 313, and Lys 332
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF4G2 (EIF4G2)
  • Abcam antibodies for DAP5

No data available for DME Specific Peptides for EIF4G2 Gene

Domains & Families for EIF4G2 Gene

Graphical View of Domain Structure for InterPro Entry

P78344

UniProtKB/Swiss-Prot:

IF4G2_HUMAN :
  • Contains 1 MI domain.
  • Belongs to the eukaryotic initiation factor 4G family.
Domain:
  • Contains 1 MI domain.
  • Contains 1 MIF4G domain.
  • Contains 1 W2 domain.
Family:
  • Belongs to the eukaryotic initiation factor 4G family.
genes like me logo Genes that share domains with EIF4G2: view

No data available for Gene Families for EIF4G2 Gene

Function for EIF4G2 Gene

Molecular function for EIF4G2 Gene

GENATLAS Biochemistry:
eukaryotic translation initiation factor 4 gamma 2 wheat eIF-(iso)4F,p82 subunit,and mammalian iIF-4G (EIF4G) homolog,involved in the binding of mRNA cap structure to ribosome,also interacting with the poly (A)-binding protein (PABPx) and increasing its RNA binding activity
UniProtKB/Swiss-Prot Function:
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.

Gene Ontology (GO) - Molecular Function for EIF4G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IDA 11943866
GO:0005515 protein binding IEA,IPI 16166382
GO:0008135 translation factor activity, RNA binding IDA 16289705
genes like me logo Genes that share ontologies with EIF4G2: view
genes like me logo Genes that share phenotypes with EIF4G2: view

Animal Models for EIF4G2 Gene

MGI Knock Outs for EIF4G2:

Animal Model Products

CRISPR Products

miRNA for EIF4G2 Gene

miRTarBase miRNAs that target EIF4G2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF4G2 Gene

Localization for EIF4G2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4G2 Gene COMPARTMENTS Subcellular localization image for EIF4G2 gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for EIF4G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EIF4G2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4G2 Gene

Pathways & Interactions for EIF4G2 Gene

genes like me logo Genes that share pathways with EIF4G2: view

Pathways by source for EIF4G2 Gene

2 KEGG pathways for EIF4G2 Gene
1 GeneGo (Thomson Reuters) pathway for EIF4G2 Gene

Gene Ontology (GO) - Biological Process for EIF4G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008219 cell death TAS 9032289
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with EIF4G2: view

No data available for SIGNOR curated interactions for EIF4G2 Gene

Drugs & Compounds for EIF4G2 Gene

(2) Drugs for EIF4G2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0
4EGI-1 Pharma Competitive eIF4E/eIF4G interaction inhibitor 0

(2) ApexBio Compounds for EIF4G2 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4G2: view

Transcripts for EIF4G2 Gene

Unigene Clusters for EIF4G2 Gene

Eukaryotic translation initiation factor 4 gamma, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4:
SP5: - - - - - - -
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18: - - - - - -
SP19: - -
SP20:
SP21:
SP22: - - - - - - -
SP23:

ExUns: 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5:
SP6:
SP7: - - -
SP8: - - - -
SP9: - -
SP10: -
SP11: - - - -
SP12:
SP13:
SP14:
SP15:
SP16: - - - -
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:

ExUns: 25b · 25c · 25d ^ 26a · 26b ^ 27a · 27b · 27c
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for EIF4G2 Gene

GeneLoc Exon Structure for
EIF4G2
ECgene alternative splicing isoforms for
EIF4G2

Expression for EIF4G2 Gene

mRNA expression in normal human tissues for EIF4G2 Gene

Protein differential expression in normal tissues from HIPED for EIF4G2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.1) and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EIF4G2 Gene



SOURCE GeneReport for Unigene cluster for EIF4G2 Gene Hs.183684

mRNA Expression by UniProt/SwissProt for EIF4G2 Gene

P78344-IF4G2_HUMAN
Tissue specificity: Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney.
genes like me logo Genes that share expression patterns with EIF4G2: view

Protein tissue co-expression partners for EIF4G2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF4G2 Gene

Orthologs for EIF4G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4G2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4G2 35
  • 96.95 (n)
  • 100 (a)
EIF4G2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4G2 35
  • 97.5 (n)
  • 99.89 (a)
EIF4G2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4g2 35
  • 95.3 (n)
  • 99.1 (a)
Eif4g2 16
Eif4g2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4G2 35
  • 99.78 (n)
  • 100 (a)
EIF4G2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4g2 35
  • 95.56 (n)
  • 99.22 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF4G2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4G2 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4G2 35
  • 89.95 (n)
  • 94.71 (a)
EIF4G2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4G2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4g2 35
  • 82.2 (n)
  • 88.06 (a)
Str.6664 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24133 35
zebrafish
(Danio rerio)
Actinopterygii naca 35
eif4g2a 36
  • 84 (a)
OneToMany
eif4g2b 36
  • 84 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13445 35
fruit fly
(Drosophila melanogaster)
Insecta l(2)01424 37
  • 41 (a)
NAT1 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ifg-1 36
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF4631 36
  • 12 (a)
ManyToMany
TIF4632 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2762 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3697 36
  • 36 (a)
OneToOne
Species with no ortholog for EIF4G2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4G2 Gene

ENSEMBL:
Gene Tree for EIF4G2 (if available)
TreeFam:
Gene Tree for EIF4G2 (if available)

Paralogs for EIF4G2 Gene

Paralogs for EIF4G2 Gene

genes like me logo Genes that share paralogs with EIF4G2: view

Variants for EIF4G2 Gene

Sequence variations from dbSNP and Humsavar for EIF4G2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_048923 -
rs1804746 -- 10,797,084(-) ATACT(G/T)GTATC utr-variant-3-prime
rs2242360 -- 10,804,794(-) AGGTA(C/T)GTATT intron-variant
rs2242361 -- 10,804,709(-) ATGGT(A/G)TGGTT intron-variant
rs7117587 -- 10,798,317(+) TACAA(C/G)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4G2 Gene

Variant ID Type Subtype PubMed ID
esv989984 CNV Insertion 20482838
esv1579756 CNV Insertion 17803354

Variation tolerance for EIF4G2 Gene

Residual Variation Intolerance Score: 5.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EIF4G2 Gene

Disorders for EIF4G2 Gene

Relevant External Links for EIF4G2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4G2

No disorders were found for EIF4G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4G2 Gene

Publications for EIF4G2 Gene

  1. DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. (PMID: 9032289) Levy-Strumpf N. … Kimchi A. (Mol. Cell. Biol. 1997) 2 3 4 23 67
  2. DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis. (PMID: 18450493) Marash L. … Kimchi A. (Mol. Cell 2008) 3 23
  3. The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage. (PMID: 18722383) Liberman N. … Kimchi A. (J. Mol. Biol. 2008) 3 23
  4. The eIF4G-homolog p97 can activate translation independent of caspase cleavage. (PMID: 17237356) Nousch M. … Preiss T. (RNA 2007) 3 23
  5. p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. (PMID: 16932749) Lee S.H. … McCormick F. (EMBO J. 2006) 3 23

Products for EIF4G2 Gene

Sources for EIF4G2 Gene

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