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EIF4G1 Gene

protein-coding   GIFtS: 68
GCID: GC03P184032

Eukaryotic Translation Initiation Factor 4 Gamma, 1


(Previous symbols: EIF4G, EIF4F)
  See EIF4G1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 4 Gamma, 11 2     EIF4-gamma2
EIF4G1 2 3 5     P2202
EIF4F1 2 3     Eucaryotic Translation Initiation Factor 4G2
EIF4GI2 3     Eukaryotic Translation Initiation Factor 4 Gamma 12
EIF-4-Gamma 12 3     eIF-4G13
PARK182 5     EIF-4G 13
EIF-4G12     p2203

External Ids:    HGNC: 32961   Entrez Gene: 19812   Ensembl: ENSG000001148677   OMIM: 6004955   UniProtKB: Q046373   

Export aliases for EIF4G1 gene to outside databases

Previous GC identifers: GC03M180550 GC03P185026 GC03P185434 GC03P185355 GC03P185356 GC03P185515 GC03P181439


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF4G1 Gene:
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex
facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of
protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary
structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding
protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also
interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation.
Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter
usage. (provided by RefSeq, Aug 2010)

GeneCards Summary for EIF4G1 Gene:
EIF4G1 (eukaryotic translation initiation factor 4 gamma, 1) is a protein-coding gene. Diseases associated with EIF4G1 include parkinson disease 18, and mouth disease. GO annotations related to this gene include translation factor activity, nucleic acid binding and translation initiation factor activity. An important paralog of this gene is EIF4G3.

UniProtKB/Swiss-Prot: IF4G1_HUMAN, Q04637
Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap,
ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome

Gene Wiki entry for EIF4G1 (Eukaryotic translation initiation factor 4 gamma) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF4G1 gene promoter:
         p53   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF4G1 promoter sequence
   Search Chromatin IP Primers for EIF4G1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF4G1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.1   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27.1

EIF4G1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4G1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P184032:  view genomic region     (about GC identifiers)

Start:
184,032,283 bp from pter      End:
184,053,146 bp from pter
Size:
20,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IF4G1_HUMAN, Q04637 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 4 gamma 1  
Size: 1599 amino acids; 175491 Da
Subunit: eIF4F is a multi-subunit complex, the composition of which varies with external and internal
environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3,
mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its
C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding
these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to
interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes
dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation.
EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin
stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A
NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis.
Interacts with RBM4
Sequence caution: Sequence=AAC78444.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC82471.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA02185.1;
Type=Frameshift; Positions=Several; Sequence=BAD18554.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
4 PDB 3D structures from and Proteopedia for EIF4G1:
1LJ2 (3D)        1UG3 (3D)        2W97 (3D)        4F02 (3D)    
Secondary accessions: D3DNT2 D3DNT4 D3DNT5 E9PFM1 G5E9S1 O43177 O95066 Q5HYG0 Q6ZN21 Q8N102
Alternative splicing, Alternative initiation: 8 isoforms:  Q04637-1   Q04637-3   Q04637-4   Q04637-5   Q04637-6   Q04637-7   Q04637-8   Q04637-9   
(Produced by alternative splicing. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for EIF4G1: NX_Q04637

Explore proteomics data for EIF4G1 at MOPED

Post-translational modifications: 

  • Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK11
  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral
    protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA
    transcription1
  • Ubiquitination2 at Lys580, Lys593, Lys597, Lys602, Lys770, Lys795, Lys832, Lys900, Lys1059
  • Modification sites at PhosphoSitePlus

  • See EIF4G1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001181875.1  NP_001181876.1  NP_001278086.1  NP_004944.3  NP_886553.3  NP_937884.1  NP_937885.1  NP_937887.1  

    ENSEMBL proteins: 
     ENSP00000316879   ENSP00000391935   ENSP00000376320   ENSP00000407244   ENSP00000400351  
     ENSP00000391412   ENSP00000413159   ENSP00000371767   ENSP00000390755   ENSP00000403269  
     ENSP00000317600   ENSP00000415842   ENSP00000407240   ENSP00000411214   ENSP00000407682  
     ENSP00000343450   ENSP00000416255   ENSP00000415943   ENSP00000395974   ENSP00000398145  
     ENSP00000399858   ENSP00000411707   ENSP00000411826   ENSP00000409545   ENSP00000399969  
     ENSP00000404754   ENSP00000392908   ENSP00000396888   ENSP00000338020   ENSP00000323737  
    Reactome Protein details: Q04637

    EIF4G1 Human Recombinant Protein Products:

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    antibodies-online proteins for EIF4G1 (3 products) 

     
    antibodies-online peptides for EIF4G1

    EIF4G1 Antibody Products:

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    antibodies-online antibodies for EIF4G1 (109 products) 

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    antibodies-online kits for EIF4G1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PARK: Parkinson disease

    5 InterPro protein domains:
     IPR003890 MIF4G-like_typ-3
     IPR016021 MIF4-like_typ_1/2/3
     IPR003891 Initiation_fac_eIF4g_MI
     IPR003307 W2_domain
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q04637

    ProtoNet protein and cluster: Q04637

    3 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB003890 Initiation factor eIF-4 gamma
    IPB003891 Initiation factor eIF-4 gamma


    UniProtKB/Swiss-Prot: IF4G1_HUMAN, Q04637
    Similarity: Belongs to the eukaryotic initiation factor 4G family
    Similarity: Contains 1 MI domain
    Similarity: Contains 1 MIF4G domain
    Similarity: Contains 1 W2 domain


    Find genes that share domains with EIF4G1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF4G1_HUMAN, Q04637
    Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap,
    ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome

         Genatlas biochemistry entry for EIF4G1:
    eukaryotic translation initiation factor 4 gamma 1,p220 (154kDa),complexing with other EIF,involved in the binding
    of mRNA cap structure to ribosome,also interacting with the poly (A)-binding protein (PABPx) and increasing its
    RNA binding activity

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003743translation initiation factor activity TAS8961935
    GO:0005488binding ----
    GO:0005515protein binding IPI10523622
    GO:0008135translation factor activity, nucleic acid binding TAS10880459
         
    Find genes that share ontologies with EIF4G1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EIF4G1:
     Increased S DNA content  Nuclear pre-40S maturation def  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Eif4g1):
     normal 

    Find genes that share phenotypes with EIF4G1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EIF4G1

    miRNA
    Products:
        
    miRTarBase miRNAs that target EIF4G1:
    hsa-mir-1260b (MIRT052684), hsa-mir-615-3p (MIRT040339), hsa-mir-16-5p (MIRT031636), hsa-mir-455-3p (MIRT037839), hsa-mir-34a-5p (MIRT025464), hsa-mir-96-5p (MIRT027930), hsa-mir-744-5p (MIRT037651), hsa-mir-1 (MIRT023744), hsa-mir-320a (MIRT044854)

    Block miRNA regulation of human, mouse, rat EIF4G1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF4G1 (see all 12):
    hsa-miR-4283 hsa-miR-4254 hsa-miR-185* hsa-miR-513a-3p hsa-miR-374b hsa-miR-503 hsa-miR-374a hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidEIF4G1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 7): EIF4G1 (NM_198241)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF4G1
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    Addgene plasmids for EIF4G1 

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    eBioscience FlowRNA Probe Sets ( VA1-12120) for EIF4G1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0016281eukaryotic translation initiation factor 4F complex TAS9857202

    Find genes that share ontologies with EIF4G1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF4G1 About   (see all 21)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    Signaling by Insulin receptor0.80
    IRS-related events0.94
    PKB-mediated events0.41
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    mTOR signalling0.39
    IRS-mediated signalling0.92
    mTORC1-mediated signalling0.00
    2Influenza Viral RNA Transcription and Replication
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Eukaryotic Translation Initiation0.89
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Nonsense-Mediated Decay0.89
    Cap-dependent Translation Initiation0.89
    Translation0.82
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    Ribosomal scanning and start codon recognition0.91
    5CDK-mediated phosphorylation and removal of Cdc6
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62


    Find genes that share SuperPaths with EIF4G1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for EIF4G1
        Akt Signaling Pathway

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF4G1
        eIF2 Pathway
    mTOR Pathway
    Regulation of eIF4 and p70S6K
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF4G1
        Translational Control

    3 GeneGo (Thomson Reuters) Pathways for EIF4G1
        Translation Insulin regulation of translation
    Translation Regulation of EIF4F activity
    Translation Translation regulation by Alpha-1 adrenergic receptors

    2 BioSystems Pathways for EIF4G1
        Translation Factors
    Validated targets of C-MYC transcriptional activation


    Selected Reactome Pathways for EIF4G1 (see all 11)
        Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    S6K1 signalling


    2 Kegg Pathways  (Kegg details for EIF4G1):
        RNA transport
    Viral myocarditis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EIF4G1: 
              PI3K-AKT Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EIF4G1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF4G1 (Q046371, 2, 3 ENSP000003168794) via UniProtKB, MINT, STRING, and/or I2D (see all 331)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119401, 2, 3, ENSP000003130074EBI-73711,EBI-81531 MINT-17563 MINT-17562 I2D: score=4 STRING: ENSP00000313007
    MKNK1Q9BUB52, 3, ENSP000003610144MINT-13801 MINT-13802 MINT-13800 I2D: score=5 STRING: ENSP00000361014
    EIF4A2Q142402, 3, ENSP000003263814MINT-17061 I2D: score=4 STRING: ENSP00000326381
    NCBP1Q091612, 3, ENSP000003642894MINT-4791425 I2D: score=4 STRING: ENSP00000364289
    EIF3BP558842, 3, ENSP000003541254MINT-8409716 I2D: score=3 STRING: ENSP00000354125
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    Find genes that share ontologies with EIF4G1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Selected Novoseek inferred chemical compound relationships for EIF4G1 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    m7gtp 78.8 5 14701818 (1), 16281055 (1), 17942399 (1)
    rapamycin 65.1 13 16990847 (2), 17634251 (1), 11855825 (1), 9879998 (1) (see all 9)
    adenylate 51.4 31 9918691 (3), 11533233 (3), 16772376 (2), 14645908 (2) (see all 17)
    phosphatidylinositol 24.3 3 10753934 (1), 11855825 (1), 15452223 (1)
    mg 132 22.5 6 11513883 (4), 15317596 (1)
    pd 98,059 20.6 2 11855825 (1), 16990847 (1)
    ly294002 15.3 1 17372272 (1)
    cysteine 14.5 4 12228254 (1), 9049313 (1), 16415022 (1)
    wortmannin 11.5 3 16990847 (2), 11855825 (1)
    guanosine 6 1 10802729 (1)



    Find genes that share compounds with EIF4G1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF4G1 gene (8 alternative transcripts): 
    NM_001194946.1  NM_001194947.1  NM_001291157.1  NM_004953.4  NM_182917.4  NM_198241.2  NM_198242.2  NM_198244.2  

    Unigene Cluster for EIF4G1:

    Eukaryotic translation initiation factor 4 gamma, 1
    Hs.433750  [show with all ESTs]
    Unigene Representative Sequence: NM_182917
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 39):
    ENST00000346169(uc003fno.2 uc010hxw.2 uc010hxx.3 uc010hxy.3 uc003fnp.3 uc003fnq.3 uc003fnr.3)
    ENST00000414031(uc003fns.3) ENST00000392537 ENST00000444134 ENST00000442406(uc003fnt.3)
    ENST00000450424 ENST00000421110 ENST00000382330 ENST00000413967 ENST00000426123
    ENST00000350481 ENST00000455679 ENST00000485712 ENST00000440448 ENST00000427141
    ENST00000427845(uc010hxz.2) ENST00000342981(uc003fnv.4) ENST00000424196(uc003fnw.3)

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    hsa-miR-4283 hsa-miR-4254 hsa-miR-185* hsa-miR-513a-3p hsa-miR-374b hsa-miR-503 hsa-miR-374a hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidEIF4G1 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat EIF4G1
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    OriGene ORF clones in mouse, rat for EIF4G1
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    GenScript: all cDNA clones in your preferred vector (see all 7): EIF4G1 (NM_198241)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF4G1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4G1
    Addgene plasmids for EIF4G1 
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    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12120) for EIF4G1 

    Additional mRNA sequence: 

    AF002815.1 AF002816.1 AF104913.1 AF281070.1 AJ001046.1 AK096719.1 AK128378.1 AK131407.1 
    AK226160.1 AK294567.1 AK299763.1 AK308319.1 AL832754.1 AY082886.1 BC007788.2 BC010688.1 
    BC065256.1 BC082764.1 BC140892.1 BC140896.1 BT007282.1 BX647812.1 D12686.1 

    Selected DOTS entries (see all 57):

    DT.97771411  DT.100644389  DT.100866154  DT.100654474  DT.40230468  DT.97793095  DT.97771566  DT.100654480 
    DT.100034468  DT.95192589  DT.100725669  DT.100654483  DT.120928742  DT.70103771  DT.100045274  DT.95285895 
    DT.100839598  DT.91719236  DT.100654475  DT.100857624  DT.120928797  DT.120928829  DT.95285930  DT.100843813 

    Selected AceView cDNA sequences (see all 1089):

    BQ021186 BC082764 BG818858 BQ070035 AU124800 BM909913 BE792956 BG476531 
    BM855118 BM453155 AA074421 AI676137 CD359128 CR614210 AU120219 NM_198244 
    BM670511 AU122303 BU682449 AW250908 AW369892 BU944064 AL045679 BU182649 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G1 (see all 37)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^
    SP1:                                                                                                                                                            
    SP2:                                                              -                             -           -     -     -     -     -     -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:  -           -                                                                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c · 29d ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 38a · 38b ^ 39 ^ 40a · 40b · 40c ·
    SP1:        -     -                     
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for EIF4G1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EIF4G1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCAATTA
    EIF4G1 Expression
    About this image


    EIF4G1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    EIF4G1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF4G1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433750
        Pathway & Disease-focused RT2 Profiler PCR Arrays including EIF4G1: 
              PI3K-AKT Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4G1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EIF4G1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif4g11 , 5 eukaryotic translation initiation factor 4, gamma 11, 5 88.09(n)1
    91.12(a)1
      16 (12.49 cM)5
    2086431  NM_145941.21  NP_666053.21 
     206683135 
    chicken
    (Gallus gallus)
    Aves EIF4G11 eukaryotic translation initiation factor 4 gamma, 1 74.49(n)
    82.65(a)
      424953  XM_004943411.1  XP_004943468.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF4G16
    eukaryotic translation initiation factor 4 gamma, ...
    68(a)
    1 ↔ 1
    GL343245.1(200116-262973)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA792687.12   -- 73.87(n)    CA792687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.164032 Transcribed sequence with weak similarity to protein more 81.91(n)    BI474896.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF4G6
    eIF4G26
    eukaryotic translation initiation factor 4G2
    22(a)
    16(a)
    many ↔ many
    many ↔ many
    4(935911-951347)
    3R(19635550-19644364)
    worm
    (Caenorhabditis elegans)
    Secernentea ifg-16
    Protein IFG-1, isoform a
    22(a)
    1 → many
    II(8217231-8222201) WBGene00002066
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF46326
    TIF46316
    Translation initiation factor eIF4G, subunit of th...
    Translation initiation factor eIF4G, subunit of th...
    21(a)
    21(a)
    many ↔ many
    many ↔ many
    VII(406860-409604) YGL049C
    VII(824059-826917) YGR162W


    ENSEMBL Gene Tree for EIF4G1 (if available)
    TreeFam Gene Tree for EIF4G1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF4G1 gene
    EIF4G32  EIF4G22  
    2 SIMAP similar genes for EIF4G1 using alignment to 23 protein entries:     IF4G1_HUMAN (see all proteins):
    EIF4G1 variant protein    EIF4G3

    Find genes that share paralogs with EIF4G1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EIF4G1 (see all 597)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1112909361,2,,4
    CParkinson disease 18 (PARK18)4 --184039877(+) GGCAGC/TAGCAG 14 A V mis10--------
    rs1121764501,2,,4
    CParkinson disease 18 (PARK18)4 --184045189(+) GCTGCA/GCAAGG 14 H R mis10--------
    VAR_0361174
    A colorectal cancer sample4--see VAR_0361172 P L mis40--------
    rs1128976631,2
    C,F--181437617(+) GGGTGG/CTCTCG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1814929521,2
    --181437670(+) GTGCTA/GGAATT 1 -- us2k10--------
    rs1864467511,2
    C--181437682(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs564082541,2
    --181437717(+) TTTTTA/CTTTTT 1 -- us2k10--------
    rs1433622011,2
    --181437745(+) CTCACC/TGTCAT 1 -- us2k10--------
    rs76491241,2
    C,F,H--181437791(+) tgcaaC/Gctctg 1 -- us2k16Minor allele frequency- G:0.33NA WA 12
    rs343905331,2
    C--181437802(+) CCTCCC/AGGGTT 1 -- us2k12Minor allele frequency- A:0.25NA 4

    HapMap Linkage Disequilibrium report for EIF4G1 (184032283 - 184053146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for EIF4G1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422400CNV Duplication17116639
    nsv878060CNV Loss21882294
    nsv829813CNV Loss17160897
    nsv878057CNV Loss21882294

    Human Gene Mutation Database (HGMD): EIF4G1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF4G1
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF4G1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600495   
    OMIM disorders: 614251  
    UniProtKB/Swiss-Prot: IF4G1_HUMAN, Q04637
  • Parkinson disease 18 (PARK18) [MIM:614251]: An autosomal dominant, late-onset form of Parkinson disease.
    Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular
    rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa.
    The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies
    (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 6 diseases for EIF4G1:    
    About MalaCards
    parkinson disease 18    mouth disease    parkinson disease 1    lewy body dementia
    laryngeal carcinoma    parkinson's disease


    Find genes that share disorders with EIF4G1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EIF4G1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    foot-and-mouth disease 72.9 10 9857201 (2), 11073214 (1), 8057448 (1), 11257179 (1) (see all 8)
    virus infection 43.3 12 9857201 (2), 11073214 (1), 8057448 (1), 11257179 (1) (see all 10)
    laryngeal carcinoma 15 1 16408751 (1)
    shock 4.95 15 19087191 (4), 10859165 (2), 16505970 (1), 10477262 (1) (see all 5)
    necrosis 4.42 3 15743837 (1), 1345341 (1)
    carcinoma squamous cell 0 3 17290396 (2), 11857405 (1)
    herpes simplex 0 1 16481474 (1)
    lung carcinoma 0 1 11857405 (1)
    breast cancer 0 1 18426977 (1)
    tumors 0 16 11857405 (2), 20398343 (1), 17060447 (1), 18426977 (1) (see all 11)


    Export disorders for EIF4G1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for EIF4G1 gene, integrated from 10 sources (see all 380):
    (articles sorted by number of sources associating them with EIF4G1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. (PubMed id 9372926)1, 2, 3, 9 Imataka H. and Sonenberg N. (Mol. Cell. Biol. 1997)
    2. Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma. (PubMed id 1429670)1, 2, 3, 9 Yan R.... Rhoads R.E. (J. Biol. Chem. 1992)
    3. Translation initiator EIF4G1 mutations in familial Parkinson disease. (PubMed id 21907011)1, 2, 3 Chartier-Harlin M.C.... Farrer M.J. (Am. J. Hum. Genet. 2011)
    4. A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases. (PubMed id 8961935)1, 2, 9 Lamphear B.J. and Rhoads R.E. (Biochemistry 1996)
    5. A novel functional human eukaryotic translation initiation factor 4G. (PubMed id 9418880)1, 2, 9 Gradi A....Sonenberg N. (Mol. Cell. Biol. 1998)
    6. Rotavirus RNA binding protein NSP3, interacts with eIF-4GI and evicts the poly(A) binding protein from eIF4F. (PubMed id 9755181)1, 2, 9 Piron M.... Poncet D. (EMBO J. 1998)
    7. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. (PubMed id 9857202)1, 2, 9 Imataka H.... Sonenberg N. (EMBO J. 1998)
    8. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. (PubMed id 10872469)1, 2, 9 Gingras A.-C.... Sonenberg N. (Annu. Rev. Biochem. 1999)
    9. Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. (PubMed id 16698552)1, 2, 9 Bellsolell L.... Burley S.K. (Structure 2006)
    10. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PubMed id 9878069)1, 2, 9 Pyronnet S....Sonenberg N. (EMBO J. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1981 HGNC: 3296 AceView: EIF4G1 Ensembl:ENSG00000114867 euGenes: HUgn1981
    ECgene: EIF4G1 Kegg: 1981 H-InvDB: EIF4G1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF4G1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF4G1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF4G1 gene:
    Search GeneIP for patents involving EIF4G1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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