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Aliases for EIF4G1 Gene

Aliases for EIF4G1 Gene

  • Eukaryotic Translation Initiation Factor 4 Gamma 1 2 3 5
  • EIF-4-Gamma 1 3 4
  • EIF-4G1 3 4
  • EIF4GI 3 4
  • EIF4F 3 4
  • EIF4G 3 4
  • P220 3 4
  • Eukaryotic Translation Initiation Factor 4 Gamma, 1 2
  • Eucaryotic Translation Initiation Factor 4G 3
  • EIF4-Gamma 3
  • EIF-4G 1 4
  • PARK18 3

External Ids for EIF4G1 Gene

Previous HGNC Symbols for EIF4G1 Gene

  • EIF4G
  • EIF4F

Previous GeneCards Identifiers for EIF4G1 Gene

  • GC03M180550
  • GC03P185026
  • GC03P185434
  • GC03P185355
  • GC03P185356
  • GC03P185515
  • GC03P184032
  • GC03P181439

Summaries for EIF4G1 Gene

Entrez Gene Summary for EIF4G1 Gene

  • The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

GeneCards Summary for EIF4G1 Gene

EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma 1) is a Protein Coding gene. Diseases associated with EIF4G1 include Parkinson Disease 18 and Eif4g1-Related Parkinson Disease. Among its related pathways are Interferon gamma signaling and mTOR signaling pathway (KEGG). GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is EIF4G3.

UniProtKB/Swiss-Prot for EIF4G1 Gene

  • Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome.

Gene Wiki entry for EIF4G1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4G1 Gene

Genomics for EIF4G1 Gene

Regulatory Elements for EIF4G1 Gene

Enhancers for EIF4G1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F184523 1.3 Ensembl ENCODE 10.7 +210.7 210707 2.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 FOS PAF1 SP3 SP5 MAGEF1 LINC02054 CHRD THPO LINC01840 CLCN2 POLR2H EPHB3 FAM131A EIF4G1
GH03F184371 1.2 Ensembl ENCODE 10.9 +57.4 57406 1.0 ELF3 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 RAD21 RARA ZNF143 LINC02054 FAM131A EIF4G1 SNORD66 LINC01840 EPHB3 PSMD2 THPO POLR2H
GH03F184543 1.2 Ensembl ENCODE 10.3 +229.7 229721 0.7 SREBF2 ZNF76 SIN3A INSM2 ARID4B NFXL1 FEZF1 ZBTB40 ZNF2 RAD21 CHRD THPO MAGEF1 FAM131A EIF4G1 LINC01840 LINC01839
GH03F184184 1.1 ENCODE 10.3 -128.4 -128398 3.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 VWA5B2 POLR2H ABCF3 EIF2B5 ALG3 ECE2 MIR1224 CAMK2N2 PSMD2 EIF4G1
GH03F184513 1.1 Ensembl ENCODE 10.3 +199.6 199645 1.7 ZNF76 ARID4B ZSCAN9 ZNF2 RAD21 GLIS2 ZNF143 ZNF280D ZNF654 REST LINC02054 LINC01840 EPHB3 FAM131A EIF4G1 EIF2B5-IT1 VPS8 LINC01839
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF4G1 on UCSC Golden Path with GeneCards custom track

Promoters for EIF4G1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001381295 805 2601 HDGF ARNT MLX ARID4B SIN3A ZNF2 YY1 GLIS2 ELK1 FOS

Genomic Location for EIF4G1 Gene

Chromosome:
3
Start:
184,314,495 bp from pter
End:
184,335,358 bp from pter
Size:
20,864 bases
Orientation:
Plus strand

Genomic View for EIF4G1 Gene

Genes around EIF4G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4G1 Gene

Proteins for EIF4G1 Gene

  • Protein details for EIF4G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04637-IF4G1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 1
    Protein Accession:
    Q04637
    Secondary Accessions:
    • D3DNT2
    • D3DNT4
    • D3DNT5
    • E9PFM1
    • G5E9S1
    • O43177
    • O95066
    • Q5HYG0
    • Q6ZN21
    • Q8N102

    Protein attributes for EIF4G1 Gene

    Size:
    1599 amino acids
    Molecular mass:
    175491 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4. Interacts with HNRNPD/AUF1; the interaction requires RNA. Interacts with human adenovirus 5 100K protein; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs (PubMed:15314025).
    SequenceCaution:
    • Sequence=AAC78444.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC82471.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA02185.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD18554.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF4G1 Gene

    Alternative splice isoforms for EIF4G1 Gene

neXtProt entry for EIF4G1 Gene

Post-translational modifications for EIF4G1 Gene

  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
  • Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.
  • Ubiquitination at Lys 580, Lys 593, Lys 602, Lys 770, Lys 795, Lys 832, and Lys 1059
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4G1 Gene

Domains & Families for EIF4G1 Gene

Gene Families for EIF4G1 Gene

Graphical View of Domain Structure for InterPro Entry

Q04637

UniProtKB/Swiss-Prot:

IF4G1_HUMAN :
  • Contains 1 MI domain.
  • Belongs to the eukaryotic initiation factor 4G family.
Domain:
  • Contains 1 MI domain.
  • Contains 1 MIF4G domain.
  • Contains 1 W2 domain.
Family:
  • Belongs to the eukaryotic initiation factor 4G family.
genes like me logo Genes that share domains with EIF4G1: view

Function for EIF4G1 Gene

Molecular function for EIF4G1 Gene

GENATLAS Biochemistry:
eukaryotic translation initiation factor 4 gamma 1,p220 (154kDa),complexing with other EIF,involved in the binding of mRNA cap structure to ribosome,also interacting with the poly (A)-binding protein (PABPx) and increasing its RNA binding activity
UniProtKB/Swiss-Prot Function:
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome.

Gene Ontology (GO) - Molecular Function for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,TAS 25255371
GO:0003729 mRNA binding IDA 24092755
GO:0003743 translation initiation factor activity TAS 8961935
GO:0005515 protein binding IPI 10523622
GO:0005524 ATP binding IDA 25255371
genes like me logo Genes that share ontologies with EIF4G1: view
genes like me logo Genes that share phenotypes with EIF4G1: view

Human Phenotype Ontology for EIF4G1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EIF4G1 Gene

MGI Knock Outs for EIF4G1:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for EIF4G1 Gene

Localization for EIF4G1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4G1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 18426977
GO:0005737 cytoplasm IMP,IDA 18426977
GO:0005829 cytosol TAS --
GO:0005844 polysome IMP 18426977
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with EIF4G1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4G1 Gene

Pathways & Interactions for EIF4G1 Gene

genes like me logo Genes that share pathways with EIF4G1: view

Gene Ontology (GO) - Biological Process for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0001662 behavioral fear response IEA --
GO:0002191 cap-dependent translational initiation TAS 25765080
GO:0006412 translation IEA,IPI 24092755
genes like me logo Genes that share ontologies with EIF4G1: view

No data available for SIGNOR curated interactions for EIF4G1 Gene

Drugs & Compounds for EIF4G1 Gene

(16) Drugs for EIF4G1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0
4EGI-1 Pharma Competitive eIF4E/eIF4G interaction inhibitor 0

(10) Additional Compounds for EIF4G1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for EIF4G1 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4G1: view

Drug Products

Transcripts for EIF4G1 Gene

Unigene Clusters for EIF4G1 Gene

Eukaryotic translation initiation factor 4 gamma, 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^
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SP36: - - -
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ExUns: 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^
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ExUns: 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c · 29d ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^
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ExUns: 38a · 38b ^ 39 ^ 40a · 40b · 40c ·
SP1: - -
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Relevant External Links for EIF4G1 Gene

GeneLoc Exon Structure for
EIF4G1
ECgene alternative splicing isoforms for
EIF4G1

Expression for EIF4G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF4G1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for EIF4G1 Gene

This gene is overexpressed in Lymph node (6.2) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF4G1 Gene



Protein tissue co-expression partners for EIF4G1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4G1 Gene:

EIF4G1

SOURCE GeneReport for Unigene cluster for EIF4G1 Gene:

Hs.433750
genes like me logo Genes that share expression patterns with EIF4G1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for EIF4G1 Gene

Orthologs for EIF4G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4G1 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia EIF4G1 34 35
  • 91.64 (n)
cow
(Bos Taurus)
Mammalia EIF4G1 34 35
  • 90.8 (n)
mouse
(Mus musculus)
Mammalia Eif4g1 34 16 35
  • 88.09 (n)
rat
(Rattus norvegicus)
Mammalia Eif4g1 34
  • 87.91 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4G1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4G1 34 35
  • 74.49 (n)
lizard
(Anolis carolinensis)
Reptilia EIF4G1 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4g3 34
  • 64.68 (n)
zebrafish
(Danio rerio)
Actinopterygii EIF4G1 (2 of 3) 35
  • 67 (a)
OneToMany
EIF4G1 (1 of 3) 35
  • 59 (a)
OneToMany
CABZ01085054.1 35
  • 54 (a)
OneToMany
Dr.16403 34
fruit fly
(Drosophila melanogaster)
Insecta eIF4G 35
  • 22 (a)
ManyToMany
eIF4G2 35
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ifg-1 35
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF4631 35
  • 21 (a)
ManyToMany
TIF4632 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for EIF4G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4G1 Gene

ENSEMBL:
Gene Tree for EIF4G1 (if available)
TreeFam:
Gene Tree for EIF4G1 (if available)

Paralogs for EIF4G1 Gene

Variants for EIF4G1 Gene

Sequence variations from dbSNP and Humsavar for EIF4G1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111290936 Parkinson disease 18 (PARK18) [MIM:614251], other 184,322,089(+) GGCAG(C/T)AGCAG reference, missense
rs112176450 Parkinson disease 18 (PARK18) [MIM:614251], other 184,327,401(+) GCTGC(A/G)CAAGG reference, missense
rs754755344 A colorectal cancer sample 184,323,240(+) TGGGC(C/T)GGTGA reference, missense
rs1061353 -- 184,335,219(+) ATTTT(C/T)TGAAA upstream-variant-2KB, utr-variant-3-prime
rs111226425 -- 184,319,711(+) GCCCA(A/C)GGGGT upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF4G1 Gene

Variant ID Type Subtype PubMed ID
nsv829813 CNV loss 17160897
esv2422400 CNV duplication 17116639
dgv2650n106 CNV deletion 24896259

Variation tolerance for EIF4G1 Gene

Residual Variation Intolerance Score: 2.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4G1 Gene

Human Gene Mutation Database (HGMD)
EIF4G1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4G1 Gene

Disorders for EIF4G1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EIF4G1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
parkinson disease 18
  • parkinson disease 18 autosomal dominant
eif4g1-related parkinson disease
  • parkinson disease 18
hereditary late-onset parkinson disease
  • autosomal dominant late-onset parkinson disease
mouth disease
  • mouth disorders
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

IF4G1_HUMAN
  • Parkinson disease 18 (PARK18) [MIM:614251]: An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269 PubMed:21907011}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for EIF4G1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4G1
genes like me logo Genes that share disorders with EIF4G1: view

No data available for Genatlas for EIF4G1 Gene

Publications for EIF4G1 Gene

  1. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. (PMID: 9372926) Imataka H. … Sonenberg N. (Mol. Cell. Biol. 1997) 2 3 4 22 64
  2. Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma. (PMID: 1429670) Yan R. … Rhoads R.E. (J. Biol. Chem. 1992) 2 3 4 22 64
  3. Translation initiator EIF4G1 mutations in familial Parkinson disease. (PMID: 21907011) Chartier-Harlin M.C. … Farrer M.J. (Am. J. Hum. Genet. 2011) 2 3 4 64
  4. Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. (PMID: 16698552) Bellsolell L. … Burley S.K. (Structure 2006) 3 4 22 64
  5. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PMID: 9878069) Pyronnet S. … Sonenberg N. (EMBO J. 1999) 3 4 22 64

Products for EIF4G1 Gene

Sources for EIF4G1 Gene