Aliases for EIF4ENIF1 Gene
External Ids for EIF4ENIF1 Gene
Previous GeneCards Identifiers for EIF4ENIF1 Gene
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for EIF4ENIF1 Gene
EIF4ENIF1 (Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1) is a Protein Coding gene. Diseases associated with EIF4ENIF1 include Erythromelalgia and Hemorrhagic Thrombocythemia. Among its related pathways are Translational Control. GO annotations related to this gene include poly(A) RNA binding and protein transporter activity.
UniProtKB/Swiss-Prot for EIF4ENIF1 Gene
Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism.