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Aliases for EIF4ENIF1 Gene

Aliases for EIF4ENIF1 Gene

  • Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1 2 3 4 5
  • EIF4E Transporter 3 4
  • 4E-T 3 4
  • EIF4E-Transporter 3
  • 2610509L04Rik 3
  • Clast4 3

External Ids for EIF4ENIF1 Gene

Previous GeneCards Identifiers for EIF4ENIF1 Gene

  • GC22M028531
  • GC22M030159
  • GC22M031835
  • GC22M014796

Summaries for EIF4ENIF1 Gene

Entrez Gene Summary for EIF4ENIF1 Gene

  • The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for EIF4ENIF1 Gene

EIF4ENIF1 (Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1) is a Protein Coding gene. Diseases associated with EIF4ENIF1 include erythromelalgia and hemorrhagic thrombocythemia. GO annotations related to this gene include poly(A) RNA binding and protein transporter activity.

UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

  • Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism.

Gene Wiki entry for EIF4ENIF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4ENIF1 Gene

Genomics for EIF4ENIF1 Gene

Regulatory Elements for EIF4ENIF1 Gene

Promoters for EIF4ENIF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF4ENIF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF4ENIF1 Gene

Chromosome:
22
Start:
31,436,963 bp from pter
End:
31,496,108 bp from pter
Size:
59,146 bases
Orientation:
Minus strand

Genomic View for EIF4ENIF1 Gene

Genes around EIF4ENIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4ENIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4ENIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4ENIF1 Gene

Proteins for EIF4ENIF1 Gene

  • Protein details for EIF4ENIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRA8-4ET_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E transporter
    Protein Accession:
    Q9NRA8
    Secondary Accessions:
    • B1AKL2
    • B1AKL3
    • B2RBF1
    • Q8NCF2
    • Q9H708

    Protein attributes for EIF4ENIF1 Gene

    Size:
    985 amino acids
    Molecular mass:
    108201 Da
    Quaternary structure:
    • Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.
    SequenceCaution:
    • Sequence=BAB15092.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF4ENIF1 Gene

    Alternative splice isoforms for EIF4ENIF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4ENIF1 Gene

Proteomics data for EIF4ENIF1 Gene at MOPED

Post-translational modifications for EIF4ENIF1 Gene

  • Ubiquitination at Lys 492
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF4ENIF1 (4E-T)

No data available for DME Specific Peptides for EIF4ENIF1 Gene

Domains & Families for EIF4ENIF1 Gene

Protein Domains for EIF4ENIF1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EIF4ENIF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Function for EIF4ENIF1 Gene

Molecular function for EIF4ENIF1 Gene

UniProtKB/Swiss-Prot Function:
Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism.

Gene Ontology (GO) - Molecular Function for EIF4ENIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10856257
genes like me logo Genes that share ontologies with EIF4ENIF1: view
genes like me logo Genes that share phenotypes with EIF4ENIF1: view

Animal Model Products

CRISPR Products

miRNA for EIF4ENIF1 Gene

miRTarBase miRNAs that target EIF4ENIF1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4ENIF1 Gene

Localization for EIF4ENIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4ENIF1 Gene COMPARTMENTS Subcellular localization image for EIF4ENIF1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for EIF4ENIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EIF4ENIF1: view

Pathways & Interactions for EIF4ENIF1 Gene

SuperPathways for EIF4ENIF1 Gene

No Data Available

SIGNOR curated interactions for EIF4ENIF1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4ENIF1 Gene

None

No data available for Pathways by source for EIF4ENIF1 Gene

Drugs & Compounds for EIF4ENIF1 Gene

No Compound Related Data Available

Transcripts for EIF4ENIF1 Gene

Unigene Clusters for EIF4ENIF1 Gene

Eukaryotic translation initiation factor 4E nuclear import factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4ENIF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - -
SP2: - - - - - - - - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: - - - - - -
SP8:
SP9:
SP10: -
SP11:

ExUns: 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for EIF4ENIF1 Gene

GeneLoc Exon Structure for
EIF4ENIF1
ECgene alternative splicing isoforms for
EIF4ENIF1

Expression for EIF4ENIF1 Gene

mRNA expression in normal human tissues for EIF4ENIF1 Gene

Protein differential expression in normal tissues from HIPED for EIF4ENIF1 Gene

This gene is overexpressed in Testis (19.5), Peripheral blood mononuclear cells (7.0), Placenta (6.5), and Fetal testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4ENIF1 Gene



SOURCE GeneReport for Unigene cluster for EIF4ENIF1 Gene Hs.517559

mRNA Expression by UniProt/SwissProt for EIF4ENIF1 Gene

Q9NRA8-4ET_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with EIF4ENIF1: view

Protein tissue co-expression partners for EIF4ENIF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF4ENIF1 Gene

Orthologs for EIF4ENIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EIF4ENIF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4ENIF1 35
  • 91.87 (n)
  • 95.53 (a)
EIF4ENIF1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4ENIF1 35
  • 92.66 (n)
  • 95.94 (a)
EIF4ENIF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4enif1 35
  • 88.64 (n)
  • 90.31 (a)
Eif4enif1 16
Eif4enif1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4ENIF1 35
  • 99.76 (n)
  • 99.9 (a)
EIF4ENIF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4enif1 35
  • 88.96 (n)
  • 90.85 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF4ENIF1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves EIF4ENIF1 35
  • 76.22 (n)
  • 82.45 (a)
EIF4ENIF1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4enif1 35
  • 65.28 (n)
  • 66.88 (a)
Str.10069 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2368 35
zebrafish
(Danio rerio)
Actinopterygii eif4enif1 35
  • 59.53 (n)
  • 56.52 (a)
eif4enif1 36
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for EIF4ENIF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4ENIF1 Gene

ENSEMBL:
Gene Tree for EIF4ENIF1 (if available)
TreeFam:
Gene Tree for EIF4ENIF1 (if available)

Paralogs for EIF4ENIF1 Gene

No data available for Paralogs for EIF4ENIF1 Gene

Variants for EIF4ENIF1 Gene

Sequence variations from dbSNP and Humsavar for EIF4ENIF1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs13076 -- 31,441,958(-) ACTGG(A/G)AGAAA nc-transcript-variant, reference, synonymous-codon
rs695368 -- 31,443,419(+) TCCTT(-/CTGCAAAAG/CTGCGAAAG)GACAT intron-variant
rs695455 -- 31,437,773(+) CAGGT(A/G)TCTGT nc-transcript-variant
rs695653 -- 31,443,753(+) TTTTT(-/T)CCTTC intron-variant
rs738657 -- 31,445,763(+) CAATT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4ENIF1 Gene

Variant ID Type Subtype PubMed ID
nsv834176 CNV Loss 17160897
nsv483006 CNV Gain 15286789
nsv9897 CNV Gain 18304495

Variation tolerance for EIF4ENIF1 Gene

Residual Variation Intolerance Score: 5.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4ENIF1 Gene

HapMap Linkage Disequilibrium report
EIF4ENIF1
Human Gene Mutation Database (HGMD)
EIF4ENIF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Disorders for EIF4ENIF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF4ENIF1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
erythromelalgia
  • mitchell disease
hemorrhagic thrombocythemia
  • essential thrombocythaemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EIF4ENIF1

Genetic Association Database (GAD)
EIF4ENIF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4ENIF1
genes like me logo Genes that share disorders with EIF4ENIF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4ENIF1 Gene

Publications for EIF4ENIF1 Gene

  1. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. (PMID: 10856257) Dostie J. … Sonenberg N. (EMBO J. 2000) 2 3 4 23 67
  2. The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. (PMID: 19850929) Suzuki Y. … Minami Y. (J. Biol. Chem. 2009) 3 23
  3. Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. (PMID: 16343815) Villaescusa J.C. … Verrotti A.C. (Gene 2006) 3 23
  4. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. (PMID: 16157702) Ferraiuolo M.A. … Sonenberg N. (J. Cell Biol. 2005) 3 23
  5. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. (PMID: 24939585) Fransen E. … Friedman R.A. (Eur. J. Hum. Genet. 2015) 3

Products for EIF4ENIF1 Gene

Sources for EIF4ENIF1 Gene

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