Aliases for EIF4EBP3 Gene
External Ids for EIF4EBP3 Gene
Previous GeneCards Identifiers for EIF4EBP3 Gene
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
GeneCards Summary for EIF4EBP3 Gene
EIF4EBP3 (Eukaryotic Translation Initiation Factor 4E Binding Protein 3) is a Protein Coding gene. Among its related pathways are Translational Control and Beta-Adrenergic Signaling. GO annotations related to this gene include translation repressor activity and eukaryotic initiation factor 4E binding. An important paralog of this gene is EIF4EBP2.
UniProtKB/Swiss-Prot for EIF4EBP3 Gene
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.