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Aliases for EIF4EBP2 Gene

Aliases for EIF4EBP2 Gene

  • Eukaryotic Translation Initiation Factor 4E Binding Protein 2 2 3 5
  • EIF4E-Binding Protein 2 3 4
  • 4E-BP2 3 4
  • Phosphorylated, Heat And Acid Stable Regulated By Insulin Protein II 3
  • Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 3
  • PHASII 3
  • 4EBP2 3

External Ids for EIF4EBP2 Gene

Previous GeneCards Identifiers for EIF4EBP2 Gene

  • GC10P070925
  • GC10P071250
  • GC10P072056
  • GC10P071508
  • GC10P071834
  • GC10P072163
  • GC10P066157

Summaries for EIF4EBP2 Gene

Entrez Gene Summary for EIF4EBP2 Gene

  • This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

GeneCards Summary for EIF4EBP2 Gene

EIF4EBP2 (Eukaryotic Translation Initiation Factor 4E Binding Protein 2) is a Protein Coding gene. Among its related pathways are Longevity regulating pathway and Translational Control. GO annotations related to this gene include translation repressor activity and eukaryotic initiation factor 4E binding. An important paralog of this gene is EIF4EBP1.

UniProtKB/Swiss-Prot for EIF4EBP2 Gene

  • Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).

Gene Wiki entry for EIF4EBP2 Gene

Additional gene information for EIF4EBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4EBP2 Gene

Genomics for EIF4EBP2 Gene

Regulatory Elements for EIF4EBP2 Gene

Enhancers for EIF4EBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H070352 1.2 Ensembl ENCODE 12 -51.4 -51426 1 ELF3 FOXA2 ATF1 MLX ARID4B DMAP1 RAD21 RARA YY1 SMARCC2 EIF4EBP2 NPFFR1 PPA1 NODAL LRRC20
GH10H070357 1.2 Ensembl ENCODE dbSUPER 12 -45.9 -45930 1 PKNOX1 JUN GLI4 RELA ZNF316 POLR2A FOS NFE2 RUNX3 IKZF2 LRRC20 EIF4EBP2 NPFFR1 PPA1 NODAL UNC5B-AS1
GH10H070403 1.3 ENCODE dbSUPER 10.4 +1.1 1098 3 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 LRRC20 PALD1 NODAL EIF4EBP2 GC10M070403
GH10H071371 1.3 Ensembl ENCODE dbSUPER 10.3 +968.9 968912 3 PKNOX1 BACH1 BMI1 EBF1 BATF EED ATF7 ETV6 RUNX3 IKZF2 DNAJB12 EIF4EBP2 PIR36739 ENSG00000279406
GH10H070353 1.1 Ensembl ENCODE 12 -49.0 -48956 2 PKNOX1 ZFP64 BMI1 BATF ZNF143 ATF7 ETV6 RUNX3 CREM IKZF2 LRRC20 EIF4EBP2 NPFFR1 PPA1 UNC5B-AS1 ENSG00000280401
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF4EBP2 on UCSC Golden Path with GeneCards custom track

Promoters for EIF4EBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029394 695 2001 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1

Genomic Location for EIF4EBP2 Gene

Chromosome:
10
Start:
70,404,105 bp from pter
End:
70,428,618 bp from pter
Size:
24,514 bases
Orientation:
Plus strand

Genomic View for EIF4EBP2 Gene

Genes around EIF4EBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4EBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4EBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4EBP2 Gene

Proteins for EIF4EBP2 Gene

  • Protein details for EIF4EBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13542-4EBP2_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E-binding protein 2
    Protein Accession:
    Q13542

    Protein attributes for EIF4EBP2 Gene

    Size:
    120 amino acids
    Molecular mass:
    12939 Da
    Quaternary structure:
    • Hypophosphorylated EIF4EBP2 interacts with EIF4E; phosphorylation of EIF4EBP2 by mTORC1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:7935836, PubMed:24207126, PubMed:21661078, PubMed:25533957). Interacts with RPTOR; promoting phosphorylation by mTORC1 (By similarity). Interacts with PCMT1; required to prevent isoaspartate accumulation and convert isoaspartate to Asp (By similarity).

    Three dimensional structures from OCA and Proteopedia for EIF4EBP2 Gene

neXtProt entry for EIF4EBP2 Gene

Post-translational modifications for EIF4EBP2 Gene

  • Deamidated at Asn-99 and Asn-102 to aspartate (Asp) in brain. Deamidation promotes interaction with RPTOR, subsequent phosphorylation by mTORC1 and increased translation, leading to impair kinetics of excitatory synaptic transmission. Deamidation takes place during postnatal development, when the PI3K-Akt-mTOR signaling is reduced, suggesting it acts as a compensatory mechanism to promote translation despite attenuated PI3K-Akt-mTOR signaling in neuron development. Deamidation converts Asn residues into a mixture of Asp and isoaspartate; interactions with PCMT1 is required to prevent isoaspartate accumulation and convert isoaspartate to Asp.
  • Phosphorylation at Thr-37, Thr-46, Ser-65, Thr-70 and Ser-83 is mediated by MTOR and corresponds to the hyperphosphorylated form: it abolishes binding to EIF4E by inducing folding of intrinsically disordered regions (PubMed:24207126, PubMed:25533957). First phosphorylated at Thr-37 and Thr-46 by MTOR, inducing folding of region encompassing residues from Pro-18 to Arg-62 of into a four-stranded beta-domain that sequesters the helical YXXXXLPhi motif into a partly buried beta-strand, blocking accessibility to EIF4E. Protein phosphorylated at Thr-37 and Thr-46 is however unstable and subsequent phosphorylation at Ser-65, Thr-70 and Ser-83 is required to stabilize the fold, decreasing affinity for EIF4E by a factor of 4000 (PubMed:24207126, PubMed:25533957). Phosphorylated in response to insulin, EGF and PDGF.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF4EBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF4EBP2 (4E-BP2)

No data available for DME Specific Peptides for EIF4EBP2 Gene

Domains & Families for EIF4EBP2 Gene

Gene Families for EIF4EBP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF4EBP2 Gene

Suggested Antigen Peptide Sequences for EIF4EBP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13542

UniProtKB/Swiss-Prot:

4EBP2_HUMAN :
  • The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.
  • Belongs to the eIF4E-binding protein family.
Domain:
  • The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.
  • Intrinsically disordered protein that undergoes folding upon phosphorylation (PubMed:25533957). Hypophosphorylated form interacts strongly with EIF4E using (1) the YXXXXLPhi motif, that undergoes a disorder-to-helix transition upon binding and (2) the secondary EIF4E binding sites (residues 78-82) (PubMed:24207126, PubMed:25533957). Phosphorylation at Thr-37 and Thr-46 induces folding of region encompassing residues from Pro-18 to Arg-62 of into a four-stranded beta-domain that sequesters the helical YXXXXLPhi motif into a buried beta-strand, blocking accessibility to EIF4E. Protein phosphorylated at Thr-37 and Thr-46 is however unstable and subsequent phosphorylation at Ser-65, Thr-70 and Ser-83 is required to stabilize the fold, decreasing affinity for EIF4E by a factor of 4000 (PubMed:24207126, PubMed:25533957).
Family:
  • Belongs to the eIF4E-binding protein family.
genes like me logo Genes that share domains with EIF4EBP2: view

Function for EIF4EBP2 Gene

Molecular function for EIF4EBP2 Gene

GENATLAS Biochemistry:
eukaryotic translation initiation factor 4E,binding protein 2,implicated in the progression of cancer
UniProtKB/Swiss-Prot Function:
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).

Phenotypes From GWAS Catalog for EIF4EBP2 Gene

Gene Ontology (GO) - Molecular Function for EIF4EBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7935836
GO:0008190 eukaryotic initiation factor 4E binding ISS,IBA --
GO:0030371 translation repressor activity ISS --
genes like me logo Genes that share ontologies with EIF4EBP2: view
genes like me logo Genes that share phenotypes with EIF4EBP2: view

Animal Models for EIF4EBP2 Gene

MGI Knock Outs for EIF4EBP2:

Animal Model Products

CRISPR Products

miRNA for EIF4EBP2 Gene

miRTarBase miRNAs that target EIF4EBP2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF4EBP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF4EBP2 Gene

Localization for EIF4EBP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4EBP2 gene
Compartment Confidence
mitochondrion 3
nucleus 3
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF4EBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with EIF4EBP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4EBP2 Gene

Pathways & Interactions for EIF4EBP2 Gene

genes like me logo Genes that share pathways with EIF4EBP2: view

Pathways by source for EIF4EBP2 Gene

1 Cell Signaling Technology pathway for EIF4EBP2 Gene
1 BioSystems pathway for EIF4EBP2 Gene

SIGNOR curated interactions for EIF4EBP2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF4EBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 7935836
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
GO:0007613 memory ISS --
GO:0008286 insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with EIF4EBP2: view

Drugs & Compounds for EIF4EBP2 Gene

(1) Drugs for EIF4EBP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EIF4EBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF4EBP2: view

Transcripts for EIF4EBP2 Gene

mRNA/cDNA for EIF4EBP2 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(664) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF4EBP2 Gene

Eukaryotic translation initiation factor 4E binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF4EBP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4EBP2 Gene

No ASD Table

Relevant External Links for EIF4EBP2 Gene

GeneLoc Exon Structure for
EIF4EBP2
ECgene alternative splicing isoforms for
EIF4EBP2

Expression for EIF4EBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4EBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF4EBP2 Gene

This gene is overexpressed in Monocytes (24.6) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF4EBP2 Gene



Protein tissue co-expression partners for EIF4EBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF4EBP2 Gene:

EIF4EBP2

SOURCE GeneReport for Unigene cluster for EIF4EBP2 Gene:

Hs.621200

Evidence on tissue expression from TISSUES for EIF4EBP2 Gene

  • Nervous system(4)
  • Kidney(3.1)
  • Eye(2.8)
  • Heart(2.8)
  • Liver(2.8)
  • Muscle(2.8)
  • Lung(2.7)
  • Intestine(2.6)
  • Stomach(2.5)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with EIF4EBP2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4EBP2 Gene

Orthologs for EIF4EBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF4EBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4EBP2 33 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia EIF4EBP2 33 34
  • 96.39 (n)
dog
(Canis familiaris)
Mammalia EIF4EBP2 33 34
  • 95 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF4EBP2 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4ebp2 33 16 34
  • 91.39 (n)
rat
(Rattus norvegicus)
Mammalia Eif4ebp2 33
  • 90.56 (n)
lizard
(Anolis carolinensis)
Reptilia EIF4EBP2 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4ebp2 33
  • 80.18 (n)
MGC75579 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19119 33
zebrafish
(Danio rerio)
Actinopterygii eif4ebp2 33 34
  • 70.87 (n)
wufp45e09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10645 33
fruit fly
(Drosophila melanogaster)
Insecta Thor 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5022 34
  • 18 (a)
OneToMany
Species where no ortholog for EIF4EBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4EBP2 Gene

ENSEMBL:
Gene Tree for EIF4EBP2 (if available)
TreeFam:
Gene Tree for EIF4EBP2 (if available)

Paralogs for EIF4EBP2 Gene

Paralogs for EIF4EBP2 Gene

(2) SIMAP similar genes for EIF4EBP2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF4EBP2 Gene

genes like me logo Genes that share paralogs with EIF4EBP2: view

Variants for EIF4EBP2 Gene

Sequence variations from dbSNP and Humsavar for EIF4EBP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000089512 -- 70,409,420(+) TTTAA(C/T)AACAC intron-variant
rs1000121871 -- 70,421,409(+) GAATG(C/T)GCTCC intron-variant
rs1000229945 -- 70,412,135(+) TGTAA(A/G)GGAAG intron-variant
rs1000257142 -- 70,405,614(+) TCCTG(C/T)GGTCT intron-variant
rs1000353731 -- 70,405,788(+) GCTTT(A/G)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4EBP2 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
nsv1043245 CNV loss 25217958
nsv948059 CNV duplication 23825009

Variation tolerance for EIF4EBP2 Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4EBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4EBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4EBP2 Gene

Disorders for EIF4EBP2 Gene

Relevant External Links for EIF4EBP2

Genetic Association Database (GAD)
EIF4EBP2
Human Genome Epidemiology (HuGE) Navigator
EIF4EBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4EBP2

No disorders were found for EIF4EBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4EBP2 Gene

Publications for EIF4EBP2 Gene

  1. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. (PMID: 8975712) Tsukiyama-Kohara K … Sonenberg N (Genomics 1996) 2 3 22 60
  2. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. (PMID: 7935836) Pause A … Sonenberg N (Nature 1994) 2 3 4 60
  3. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. (PMID: 25533957) Bah A … Forman-Kay JD (Nature 2015) 3 4 60
  4. Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface. (PMID: 24207126) Lukhele S … Forman-Kay JD (Structure (London, England : 1993) 2013) 3 4 60
  5. Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1. (PMID: 21661078) Fukuyo A … Tomoo K (Journal of peptide science : an official publication of the European Peptide Society 2011) 3 4 60

Products for EIF4EBP2 Gene

Sources for EIF4EBP2 Gene

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