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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF4EBP2 Gene

protein-coding   GIFtS: 61
GCID: GC10P072163

Eukaryotic Translation Initiation Factor 4E Binding Protein...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 4E Binding Protein 21 2     PHASII2
4E-BP22 3     Eukaryotic Translation Initiation Factor 4E-Binding Protein 22
EIF4E-Binding Protein 22 3     Phosphorylated, Heat And Acid Stable Regulated By Insulin Protein II2
4EBP22 5     

External Ids:    HGNC: 32891   Entrez Gene: 19792   Ensembl: ENSG000001487307   OMIM: 6022245   UniProtKB: Q135423   

Export aliases for EIF4EBP2 gene to outside databases

Previous GC identifers: GC10P070925 GC10P071250 GC10P072056 GC10P071508 GC10P071834 GC10P066157


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EIF4EBP2 Gene:
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene
products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors
can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of
protein production through these gene products have been implicated in cell proliferation, cell differentiation
and viral infection. (provided by RefSeq, Oct 2008)

GeneCards Summary for EIF4EBP2 Gene: 
EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2) is a protein-coding gene. Diseases associated with EIF4EBP2 include sleep apnea, and alzheimer's disease, and among its related super-pathways are TGF-Beta Pathway and Erythropoietin Pathway. GO annotations related to this gene include eukaryotic initiation factor 4E binding and protein binding. An important paralog of this gene is EIF4EBP1.

UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542
Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of
protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway

Gene Wiki entry for EIF4EBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF4EBP2 gene promoter:
         NRSF form 1   AP-2alpha isoform 2   AP-2alpha   MRF-2   NRSF form 2   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF4EBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF4EBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF4EBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21-q22   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21-q22

EIF4EBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4EBP2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P072163:  view genomic region     (about GC identifiers)

Start:
72,163,861 bp from pter      End:
72,188,374 bp from pter
Size:
24,514 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 4E-binding protein 2  
Size: 120 amino acids; 12939 Da
Subunit: Nonphosphorylated EIF4EBP2 interacts with EIF4E
1 PDB 3D structure from and Proteopedia for EIF4EBP2:
3AM7 (3D)    

Explore the universe of human proteins at neXtProt for EIF4EBP2: NX_Q13542

Explore proteomics data for EIF4EBP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13542

  • EIF4EBP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF4EBP2 Protein Expression
    REFSEQ proteins: NP_004087.1  
    ENSEMBL proteins: 
     ENSP00000362314  

    Human Recombinant Protein Products for EIF4EBP2: 
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    Novus Biologicals EIF4EBP2 Proteins
    Novus Biologicals EIF4EBP2 Lysates
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for EIF4EBP2 


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008606 EIF4EBP

    Graphical View of Domain Structure for InterPro Entry Q13542

    ProtoNet protein and cluster: Q13542

    1 Blocks protein domain: IPB008606 Eukaryotic translation initiation factor 4E binding

    UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542
    Similarity: Belongs to the eIF4E-binding protein family


    EIF4EBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 4EBP2_HUMAN, Q13542
    Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of
    protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway

         Genatlas biochemistry entry for EIF4EBP2:
    eukaryotic translation initiation factor 4E,binding protein 2,implicated in the progression of cancer

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16271312
    GO:0008190eukaryotic initiation factor 4E binding IEA--
         
    EIF4EBP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EIF4EBP2:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Eif4ebp2):
     behavior/neurological  nervous system 

    EIF4EBP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Eif4ebp2tm1Klan for EIF4EBP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EIF4EBP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EIF4EBP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF4EBP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF4EBP2 

    miRNA
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    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF4EBP2 (see all 78):
    hsa-miR-3194-5p hsa-miR-200a hsa-miR-4267 hsa-miR-29a* hsa-miR-3909 hsa-miR-509-3-5p hsa-miR-30b* hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidEIF4EBP2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF4EBP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    Regulation of eIF4 and p70S6K0.43
    2Erythropoietin Pathway
    Insulin Receptor Pathway0.37
    3Translation Factors
    Translation Factors
    4Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF4EBP2
        Regulation of eIF4 and p70S6K
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF4EBP2
        Translational Control

    1 BioSystems Pathway for EIF4EBP2
        Translation Factors




    EIF4EBP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF4EBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for EIF4EBP2 (Q135422, 3 ENSP000003623144) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4EP067302, 3, ENSP000002808924MINT-19025 I2D: score=6 STRING: ENSP00000280892
    CREBBPENSP000002623674STRING: ENSP00000262367
    MTORENSP000003545584STRING: ENSP00000354558
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    COPS4ENSP000002643894STRING: ENSP00000264389
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS7935836
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0019933cAMP-mediated signaling IEA--
    GO:0045947negative regulation of translational initiation IEA--

    EIF4EBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EIF4EBP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF4EBP2 (4EBP2)

    2 Novoseek inferred chemical compound relationships for EIF4EBP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 54.4 1 20347422 (1)
    retinoic acid 26.2 6 11069026 (3), 10092805 (1)

    Search CenterWatch for drugs/clinical trials and news about EIF4EBP2 / 4EBP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF4EBP2 gene: 
    NM_004096.4  

    Unigene Cluster for EIF4EBP2:

    Eukaryotic translation initiation factor 4E binding protein 2
    Hs.621200  [show with all ESTs]
    Unigene Representative Sequence: NM_004096
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373218(uc001jrb.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF4EBP2 (see all 78):
    hsa-miR-3194-5p hsa-miR-200a hsa-miR-4267 hsa-miR-29a* hsa-miR-3909 hsa-miR-509-3-5p hsa-miR-30b* hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidEIF4EBP2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF4EBP2
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    Additional mRNA sequence: 

    AK001936.1 AK057643.1 AK313724.1 BC005057.1 BC050633.1 BT007317.1 CR542240.1 CR627373.1 
    L36056.1 

    19 DOTS entries:

    DT.95274108  DT.449454  DT.100819197  DT.100655113  DT.100692498  DT.100819206  DT.100674359  DT.100739373 
    DT.92457651  DT.95153802  DT.121272024  DT.100819199  DT.121271907  DT.92445281  DT.92457645  DT.95153798 
    DT.95153800  DT.95084454  DT.95153808 

    24/664 AceView cDNA sequences (see all 664):

    AI056185 AA421751 AA318547 CA310309 BU156716 AJ573247 AW614344 N73759 
    T32768 BU956663 BU686568 AI540632 CA412773 BF478028 BU845324 AI224895 
    CR611424 BX400222 BE646283 CR610579 BM698084 AI214818 CA413686 BU156824 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF4EBP2 expression in normal human tissues (normalized intensities)      EIF4EBP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAGTTGTT
    EIF4EBP2 Expression
    About this image


    EIF4EBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Arch Muscles
             deltoid muscle   
     
     Colon (Gastrointestinal Tract)
             colonic mucosa   
     
     Adipose (Muscoskeletal System)
             omental adipose tissue   
     
     Thyroid (Endocrine System)

    See EIF4EBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF4EBP2

    SOURCE GeneReport for Unigene cluster: Hs.621200
        SABiosciences Expression via Pathway-Focused PCR Array including EIF4EBP2: 
              mTOR Signaling in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4EBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EIF4EBP2 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif4ebp21 , 5 eukaryotic translation initiation factor 4E binding more1, 5 91.39(n)1
    95(a)1
      10 (32.21 cM)5
    136881  NM_010124.21  NP_034254.11 
     614324975 
    lizard
    (Anolis carolinensis)
    Reptilia EIF4EBP26
    Uncharacterized protein
    81(a)
    1 ↔ 1
    3(50947915-50969657)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.191192 Xenopus laevis, Similar to eukaryotic translation initiation more 81.79(n)    BC047251.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufp45e092 wufp45e09 75.8(n)   386945  CD583784.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Thor6
    Thor
    38(a)
    1 → many
    2L(3478434-3479612)


    ENSEMBL Gene Tree for EIF4EBP2 (if available)
    TreeFam Gene Tree for EIF4EBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF4EBP2 gene
    EIF4EBP12  EIF4EBP32  
    2 SIMAP similar genes for EIF4EBP2 using alignment to 2 protein entries:     4EBP2_HUMAN (see all proteins):
    EIF4EBP3    EIF4EBP1

    EIF4EBP2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for EIF4EBP2
    PGOHUM00000246762 PGOHUM00000247538 PGOHUM00000243304


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/498 SNPs in EIF4EBP2 are shown (see all 498)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745343421,2
    C,F--72161993(+) TCGTAG/ACTCAC 1 -- us2k12Minor allele frequency- A:0.07CSA WA 120
    rs1891057361,2
    --72162055(+) GTAGGC/TTGGGA 1 -- us2k10--------
    rs1814426621,2
    --72162064(+) GACTAC/TAGGTG 1 -- us2k10--------
    rs1858815531,2
    --72162082(+) CCATGC/TCTGGA 1 -- us2k10--------
    rs744724091,2
    C--72162087(+) TCTGGA/TTAATT 1 -- us2k10--------
    rs757777431,2
    C,F--72162137(+) GTCTCG/ACTTTT 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1425121281,2
    --72162511(+) TGTCTA/GTGTTC 1 -- us2k10--------
    rs1460948341,2
    --72162556(+) AGCAAC/TAGCTG 1 -- us2k10--------
    rs618581011,2
    C--72162596(+) TCTCTC/AATTTG 1 -- us2k12Minor allele frequency- A:0.03NA 122
    rs743462021,2
    C,F--72162729(+) GAGAGC/TCCCTC 1 -- us2k12Minor allele frequency- T:0.10WA EA 238

    HapMap Linkage Disequilibrium report for EIF4EBP2 (72163861 - 72188374 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EIF4EBP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv32737CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602224    OMIM disorders: --

    4 diseases for EIF4EBP2:    About MalaCards
    sleep apnea    alzheimer's disease    ovarian cancer    breast cancer


    EIF4EBP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): EIF4EBP2
    Human Genome Epidemiology (HuGE) Navigator: EIF4EBP2 (8 documents)

    Export disorders for EIF4EBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF4EBP2 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with EIF4EBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. (PubMed id 7935836)1, 2, 3 Pause A.... Sonenberg N. (1994)
    2. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. (PubMed id 8975712)1, 3, 9 Tsukiyama-Kohara K....Sonenberg N. (1996)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Defect in the regulation of 4E-BP1 and 2, two repressors of translation initiation, in the retinoid acid resistant cell lines, NB4-R1 and NB4-R2. (PubMed id 11069026)1, 9 Grolleau A....Beretta L. (2000)
    8. Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation. (PubMed id 10092805)1, 9 Grolleau A....Beretta L. (1999)
    9. Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis. (PubMed id 17316564)1, 9 Abiko F....Ishida T. (2007)
    10. Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturation. (PubMed id 9531283)1, 9 Beretta L....Sonenberg N. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1979 HGNC: 3289 AceView: EIF4EBP2 Ensembl:ENSG00000148730 euGenes: HUgn1979
    ECgene: EIF4EBP2 H-InvDB: EIF4EBP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF4EBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EIF4EBP2 gene:
    Search GeneIP for patents involving EIF4EBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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