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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EIF4EBP2 Gene

protein-coding GIFtS: 59
GCID: GC10P072163

eukaryotic translation initiation factor 4E binding protein...

Explore 5 diseases affiliated with
EIF4EBP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 4E Binding Protein 2¹ ²		PHASII²
4E-BP2² ³		Eukaryotic Translation Initiation Factor 4E-Binding Protein 2²
EIF4E-Binding Protein 2² ³		Phosphorylated, Heat And Acid Stable Regulated By Insulin Protein II²
4EBP2² ⁵

External Ids:	HGNC: 3289¹	Entrez Gene: 1979²	Ensembl: ENSG00000148730⁷	OMIM: 602224⁵	UniProtKB: Q13542³

Export aliases for EIF4EBP2 gene to outside databases

Previous GC identifers: GC10P070925 GC10P071250 GC10P072056 GC10P071508 GC10P071834 GC10P066157

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EIF4EBP2:

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products

of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release

this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production

through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.

(provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542

Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of

protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway

Gene Wiki entry for EIF4EBP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EIF4EBP2 gene promoter:
NRSF form 1 AP-2alpha isoform 2 AP-2alpha MRF-2 NRSF form 2 Gfi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EIF4EBP2 promoter sequence

Search SABiosciences Chromatin IP Primers for EIF4EBP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF4EBP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21-q22 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q21-q22

EIF4EBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4EBP2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P072163: view genomic region (about GC identifiers)

Start:	72,163,861 bp from pter	End:	72,188,374 bp from pter
Size:	24,514 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542 (See protein sequence)

Recommended Name: Eukaryotic translation initiation factor 4E-binding protein 2

Size: 120 amino acids; 12939 Da

Subunit: Nonphosphorylated EIF4EBP2 interacts with EIF4E

1 PDB 3D structure from and Proteopedia for EIF4EBP2:

3AM7 (3D)

Explore the universe of human proteins at neXtProt for EIF4EBP2: NX_Q13542

Post-translational modifications:

Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13542

EIF4EBP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004087.1

ENSEMBL proteins:

ENSP00000362314

Human Recombinant Protein Products:

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	Uscn Proteins for EIF4EBP2

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	ThermoFisher Antibody for EIF4EBP2

Assay Products for EIF4EBP2:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for EIF4EBP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EIF4EBP2 for domains About GeneDecksing

1 InterPro domain/family:

IPR008606 EIF4EBP

Graphical View of Domain Structure for InterPro Entry Q13542

ProtoNet protein and cluster: Q13542

1 Blocks protein family: IPB008606 Eukaryotic translation initiation factor 4E binding

UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542

Similarity: Belongs to the eIF4E-binding protein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542

Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of

protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway

Genatlas biochemistry entry for EIF4EBP2:

eukaryotic translation initiation factor 4E,binding protein 2,implicated in the progression of cancer

miRNA Products:		OriGene 3'-UTR Clone: EIF4EBP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EIF4EBP2
		8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF4EBP2 (see all 78):
		hsa-miR-3194-5p hsa-miR-200a hsa-miR-4267 hsa-miR-29a* hsa-miR-3909 hsa-miR-509-3-5p hsa-miR-30b* hsa-miR-4324

		SwitchGear 3'UTR luciferase reporter plasmid: EIF4EBP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF4EBP2 (see all 7) OriGene shRNA RFP: EIF4EBP2 OriGene siRNA: EIF4EBP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF4EBP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for EIF4EBP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4EBP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4EBP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EIF4EBP2 (NM_004096)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EIF4EBP2
		Search LifeMap BioReagents cell lines for EIF4EBP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4EBP2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16271312
GO:0008190	eukaryotic initiation factor 4E binding	IEA	--

EIF4EBP2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for EIF4EBP2:

Increased G1 DNA content

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Eif4ebp2^tm1Klan for EIF4EBP2
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Eif4ebp2):

behavior/neurological

nervous system

EIF4EBP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translation Factors

Translation Factors

1.00

Translational Control

Translational Control

1.00

TGF-Beta Pathway

Regulation of eIF4 and p70S6K

0.43

Erythropoietin Pathway

Insulin Receptor Pathway

0.37

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF4EBP2

	Regulation of eIF4 and p70S6K
	Insulin Receptor Pathway

1 Cell Signaling Technology (CST) Pathway for EIF4EBP2

Translational Control

1 BioSystems Pathway for EIF4EBP2

Translation Factors

EIF4EBP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for EIF4EBP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for EIF4EBP2 (Q13542^{2, 3} ENSP00000362314⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF4E	P06730²^,³, ENSP00000280892⁴	MINT-19025 I2D: score=6 STRING: ENSP00000280892
CREBBP	ENSP00000262367⁴	STRING: ENSP00000262367
MTOR	ENSP00000354558⁴	STRING: ENSP00000354558
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
COPS4	ENSP00000264389⁴	STRING: ENSP00000264389

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	TAS	7935836
GO:0008286	insulin receptor signaling pathway	IEA	--
GO:0019933	cAMP-mediated signaling	IEA	--
GO:0045947	negative regulation of translational initiation	IEA	--

EIF4EBP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EIF4EBP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EIF4EBP2
2 Novoseek chemical compound relationships for EIF4EBP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rapamycin	54.4	1	20347422 (1)
retinoic acid	26.2	6	11069026 (3), 10092805 (1)

Search CenterWatch for drugs/clinical trials and news about EIF4EBP2 / 4EBP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EIF4EBP2 gene:

NM_004096.4

Unigene Cluster for EIF4EBP2:

Eukaryotic translation initiation factor 4E binding protein 2

Hs.621200 [show with all ESTs]

Unigene Representative Sequence: NM_004096

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000373218(uc001jrb.3)

miRNA Products:		OriGene 3'-UTR Clone: EIF4EBP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EIF4EBP2
		8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF4EBP2 (see all 78):
		hsa-miR-3194-5p hsa-miR-200a hsa-miR-4267 hsa-miR-29a* hsa-miR-3909 hsa-miR-509-3-5p hsa-miR-30b* hsa-miR-4324

		SwitchGear 3'UTR luciferase reporter plasmid: EIF4EBP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF4EBP2 (see all 7) OriGene shRNA RFP: EIF4EBP2 OriGene siRNA: EIF4EBP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF4EBP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4EBP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4EBP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EIF4EBP2 (NM_004096)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF4EBP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4EBP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF4EBP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat EIF4EBP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF4EBP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF4EBP2

Additional cDNA sequence:

AK001936.1 AK057643.1 AK313724.1 BC005057.1 BC050633.1 BT007317.1 CR542240.1 CR627373.1

L36056.1

20 DOTS entries:

DT.95274108 DT.449454 DT.100819197 DT.100655113 DT.100692498 DT.100819206 DT.100674359 DT.100739373

DT.92457651 DT.95153802 DT.121272024 DT.100819199 DT.121271907 DT.92445281 DT.92457645 DT.95153797

DT.95153798 DT.95153800 DT.95153808 DT.95084454

24/664 AceView cDNA sequences (see all 664):

BU188949 AI128334 AU141744 AL599416 CR610579 BM696421 AI874393 AI224895

N73759 BU845324 AI568785 BU156716 BU156717 AL583676 AI241560 AA757533

AA454517 BU956663 AK057643 BU686568 AI202186 CA310309 AJ573247 AA318547

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EIF4EBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCAGTTGTT

About this image

EIF4EBP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Mandibular Arch Muscles

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See EIF4EBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF4EBP2

SOURCE GeneReport for Unigene cluster: Hs.621200

SABiosciences Expression via Pathway-Focused PCR Array including EIF4EBP2:

mTOR Signaling in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF4EBP2 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4EBP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for EIF4EBP2 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EIF4EBP2⁶	Uncharacterized protein	65(a)	1 ↔ 1	6(12600770-12601091)
lizard (Anolis carolinensis)	Reptilia	EIF4EBP2⁶	--	86(a)	1 ↔ 1	3(50947927-50969204)
African clawed frog (Xenopus laevis)	Amphibia	Xl.19119²	Xenopus laevis, Similar to eukaryotic translation initiation more	81.79(n)		BC047251.1
zebrafish (Danio rerio)	Actinopterygii	wufp45e09²	wufp45e09	75.8(n)		386945 CD583784.1
fruit fly (Drosophila melanogaster)	Insecta	Thor⁶	Thor	38(a)	1 → many	2L(3478434-3479612)

ENSEMBL Gene Tree for EIF4EBP2 (if available)
TreeFam Gene Tree for EIF4EBP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EIF4EBP2 gene

EIF4EBP1² EIF4EBP3²

2 SIMAP similar genes for EIF4EBP2 using alignment to 2 protein entries: 4EBP2_HUMAN (see all proteins):

EIF4EBP3 EIF4EBP1

EIF4EBP2 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for EIF4EBP2
PGOHUM00000246762 PGOHUM00000247538 PGOHUM00000243304

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74534342^1,2		--	72161993(+)	`TCGTAG/ACTCAC`	1	--	us2k¹		2		CSA WA	120
rs189105736^1,2		--	72162055(+)	`GTAGGC/TTGGGA`	1	--	us2k¹		0	--	--	--	--
rs181442662^1,2		--	72162064(+)	`GACTAC/TAGGTG`	1	--	us2k¹		0	--	--	--	--
rs185881553^1,2		--	72162082(+)	`CCATGC/TCTGGA`	1	--	us2k¹		0	--	--	--	--
rs74472409^1,2	C,	--	72162087(+)	`TCTGGA/TTAATT`	1	--	us2k¹		0	--	--	--	--
rs75777743^1,2	C,F,	--	72162137(+)	`GTCTCG/ACTTTT`	1	--	us2k¹		1		WA	118
rs142512128^1,2		--	72162511(+)	`TGTCTA/GTGTTC`	1	--	us2k¹		0	--	--	--	--
rs146094834^1,2		--	72162556(+)	`AGCAAC/TAGCTG`	1	--	us2k¹		0	--	--	--	--
rs61858101^1,2	C,	--	72162596(+)	`NNNNTC/AATTTG`	1	--	us2k¹		2		NA	122
rs74346202^1,2	F,	--	72162729(+)	`GAGAGC/TCCCTC`	1	--	us2k¹		2		WA EA	238

HapMap Linkage Disequilibrium report for EIF4EBP2 (72163861 - 72188374 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EIF4EBP2
1 CNV: 6879

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF4EBP2

DNA2.0 Custom Variant and Variant Library Synthesis for EIF4EBP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

EIF4EBP2 for disorders           About GeneDecksing

OMIM gene information: 602224    OMIM disorders: --

5 diseases for EIF4EBP2:    About MalaCards

sleep apnea apnea alzheimer's disease ovarian cancer

breast cancer

Human Genome Epidemiology (HuGE) Navigator: EIF4EBP2 (8 documents)

Export disorders for EIF4EBP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for EIF4EBP2 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with EIF4EBP2)

Utopia: connect your pdf to the dynamic
world of online information

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. (PubMed id 7935836)^{1, 2, 3} Pause A.... Sonenberg N. (1994)
Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. (PubMed id 8975712)^{1, 3, 9} Tsukiyama-Kohara K....Sonenberg N. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Defect in the regulation of 4E-BP1 and 2, two repressors of translation initiation, in the retinoid acid resistant cell lines, NB4-R1 and NB4-R2. (PubMed id 11069026)^{1, 9} Grolleau A....Beretta L. (2000)
Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation. (PubMed id 10092805)^{1, 9} Grolleau A....Beretta L. (1999)
Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis. (PubMed id 17316564)^{1, 9} Abiko F....Ishida T. (2007)
Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturation. (PubMed id 9531283)^{1, 9} Beretta L....Sonenberg N. (1998)
Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. (PubMed id 16271312)^{1, 9} Tomoo K.... Ishida T. (2005)
Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. (PubMed id 11865047)^{1, 9} Tee A.R. and Proud C.G. (2002)
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. (PubMed id 9465032)^{1, 9} Burnett P.E....Sabatini D.M. (1998)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1979	HGNC: 3289	AceView: EIF4EBP2	Ensembl:ENSG00000148730	euGenes: HUgn1979
ECgene: EIF4EBP2	H-InvDB: EIF4EBP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
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