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Aliases for EIF4EBP2 Gene

Aliases for EIF4EBP2 Gene

  • Eukaryotic Translation Initiation Factor 4E Binding Protein 2 2 3
  • EIF4E-Binding Protein 2 3 4
  • 4E-BP2 3 4
  • 4EBP2 3 6
  • Phosphorylated, Heat And Acid Stable Regulated By Insulin Protein II 3
  • Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 3
  • PHASII 3

External Ids for EIF4EBP2 Gene

Summaries for EIF4EBP2 Gene

Entrez Gene Summary for EIF4EBP2 Gene

  • This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

GeneCards Summary for EIF4EBP2 Gene

EIF4EBP2 (Eukaryotic Translation Initiation Factor 4E Binding Protein 2) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Translational Control. GO annotations related to this gene include eukaryotic initiation factor 4E binding. An important paralog of this gene is EIF4EBP1.

UniProtKB/Swiss-Prot for EIF4EBP2 Gene

  • Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).

Gene Wiki entry for EIF4EBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4EBP2 Gene

Genomics for EIF4EBP2 Gene

Genomic Location for EIF4EBP2 Gene

Start:
70,404,105 bp from pter
End:
70,428,618 bp from pter
Size:
24,514 bases
Orientation:
Plus strand

Genomic View for EIF4EBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF4EBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4EBP2 Gene

Regulatory Elements for EIF4EBP2 Gene

Proteins for EIF4EBP2 Gene

  • Protein details for EIF4EBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13542-4EBP2_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E-binding protein 2
    Protein Accession:
    Q13542
    Secondary Accessions:

    Protein attributes for EIF4EBP2 Gene

    Size:
    120 amino acids
    Molecular mass:
    12939 Da
    Quaternary structure:
    • Hypophosphorylated EIF4EBP2 interacts with EIF4E; phosphorylation of EIF4EBP2 by mTORC1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:7935836, PubMed:24207126, PubMed:21661078, PubMed:25533957). Interacts with RPTOR; promoting phosphorylation by mTORC1 (By similarity). Interacts with PCMT1; required to prevent isoaspartate accumulation and convert isoaspartate to Asp (By similarity).

    Three dimensional structures from OCA and Proteopedia for EIF4EBP2 Gene

neXtProt entry for EIF4EBP2 Gene

Proteomics data for EIF4EBP2 Gene at MOPED

Post-translational modifications for EIF4EBP2 Gene

  • Deamidated at Asn-99 and Asn-102 to aspartate (Asp) in brain. Deamidation promotes interaction with RPTOR, subsequent phosphorylation by mTORC1 and increased translation, leading to impair kinetics of excitatory synaptic transmission. Deamidation takes place during postnatal development, when the PI3K-Akt-mTOR signaling is reduced, suggesting it acts as a compensatory mechanism to promote translation despite attenuated PI3K-Akt-mTOR signaling in neuron development. Deamidation converts Asn residues into a mixture of Asp and isoaspartate; interactions with PCMT1 is required to prevent isoaspartate accumulation and convert isoaspartate to Asp.
  • Phosphorylation at Thr-37, Thr-46, Ser-65, Thr-70 and Ser-83 is mediated by MTOR and corresponds to the hyperphosphorylated form: it abolishes binding to EIF4E by inducing folding of intrinsically disordered regions (PubMed:24207126, PubMed:25533957). First phosphorylated at Thr-37 and Thr-46 by MTOR, inducing folding of region encompassing residues from Pro-18 to Arg-62 of into a four-stranded beta-domain that sequesters the helical YXXXXLPhi motif into a partly buried beta-strand, blocking accessibility to EIF4E. Protein phosphorylated at Thr-37 and Thr-46 is however unstable and subsequent phosphorylation at Ser-65, Thr-70 and Ser-83 is required to stabilize the fold, decreasing affinity for EIF4E by a factor of 4000 (PubMed:24207126, PubMed:25533957). Phosphorylated in response to insulin, EGF and PDGF.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF4EBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF4EBP2 Gene

Domains for EIF4EBP2 Gene

Protein Domains for EIF4EBP2 Gene

UniProtKB/Swiss-Prot:

4EBP2_HUMAN
Domain:
  • The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.:
    • Q13542
  • Intrinsically disordered protein that undergoes folding upon phosphorylation (PubMed:25533957). Hypophosphorylated form interacts strongly with EIF4E using (1) the YXXXXLPhi motif, that undergoes a disorder-to-helix transition upon binding and (2) the secondary EIF4E binding sites (residues 78-82) (PubMed:24207126, PubMed:25533957). Phosphorylation at Thr-37 and Thr-46 induces folding of region encompassing residues from Pro-18 to Arg-62 of into a four-stranded beta-domain that sequesters the helical YXXXXLPhi motif into a buried beta-strand, blocking accessibility to EIF4E. Protein phosphorylated at Thr-37 and Thr-46 is however unstable and subsequent phosphorylation at Ser-65, Thr-70 and Ser-83 is required to stabilize the fold, decreasing affinity for EIF4E by a factor of 4000 (PubMed:24207126, PubMed:25533957).:
    • Q13542
Family:
  • Belongs to the eIF4E-binding protein family.:
    • Q13542
genes like me logo Genes that share domains with EIF4EBP2: view

No data available for Gene Families for EIF4EBP2 Gene

Function for EIF4EBP2 Gene

Molecular function for EIF4EBP2 Gene

GENATLAS Biochemistry: eukaryotic translation initiation factor 4E,binding protein 2,implicated in the progression of cancer
UniProtKB/Swiss-Prot Function: Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).

Gene Ontology (GO) - Molecular Function for EIF4EBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15153109
GO:0008190 eukaryotic initiation factor 4E binding ISS --
GO:0030371 translation repressor activity ISS --
genes like me logo Genes that share ontologies with EIF4EBP2: view

Phenotypes for EIF4EBP2 Gene

genes like me logo Genes that share phenotypes with EIF4EBP2: view

Animal Models for EIF4EBP2 Gene

MGI Knock Outs for EIF4EBP2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EIF4EBP2 Gene

Localization for EIF4EBP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4EBP2 Gene COMPARTMENTS Subcellular localization image for EIF4EBP2 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF4EBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with EIF4EBP2: view

Pathways for EIF4EBP2 Gene

genes like me logo Genes that share pathways with EIF4EBP2: view

Pathways by source for EIF4EBP2 Gene

2 Qiagen pathways for EIF4EBP2 Gene
1 Cell Signaling Technology pathway for EIF4EBP2 Gene
1 BioSystems pathway for EIF4EBP2 Gene

Gene Ontology (GO) - Biological Process for EIF4EBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 7935836
GO:0007613 memory ISS --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0019933 cAMP-mediated signaling IEA --
GO:0031929 TOR signaling ISS --
genes like me logo Genes that share ontologies with EIF4EBP2: view

Compounds for EIF4EBP2 Gene

(2) Novoseek inferred chemical compound relationships for EIF4EBP2 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 54.4 1
retinoic acid 26.2 4
genes like me logo Genes that share compounds with EIF4EBP2: view

Transcripts for EIF4EBP2 Gene

mRNA/cDNA for EIF4EBP2 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(664) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF4EBP2 Gene

Eukaryotic translation initiation factor 4E binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4EBP2 Gene

No ASD Table

Relevant External Links for EIF4EBP2 Gene

GeneLoc Exon Structure for
EIF4EBP2
ECgene alternative splicing isoforms for
EIF4EBP2

Expression for EIF4EBP2 Gene

mRNA expression in normal human tissues for EIF4EBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4EBP2 Gene

SOURCE GeneReport for Unigene cluster for EIF4EBP2 Gene Hs.621200

genes like me logo Genes that share expressions with EIF4EBP2: view

Orthologs for EIF4EBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF4EBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4EBP2 36
  • 99.72 (n)
  • 100 (a)
EIF4EBP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4EBP2 36
  • 96.39 (n)
  • 99.17 (a)
EIF4EBP2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4EBP2 36
  • 95 (n)
  • 99.17 (a)
EIF4EBP2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4ebp2 36
  • 91.39 (n)
  • 95 (a)
Eif4ebp2 16
Eif4ebp2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF4EBP2 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4ebp2 36
  • 90.56 (n)
  • 95 (a)
lizard
(Anolis carolinensis)
Reptilia EIF4EBP2 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19119 36
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4ebp2 36
  • 80.18 (n)
  • 82.88 (a)
MGC75579 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10645 36
zebrafish
(Danio rerio)
Actinopterygii eif4ebp2 36
  • 70.87 (n)
  • 75.68 (a)
eif4ebp2 37
  • 73 (a)
OneToOne
wufp45e09 36
fruit fly
(Drosophila melanogaster)
Insecta Thor 37
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5022 37
  • 18 (a)
OneToMany
Species with no ortholog for EIF4EBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4EBP2 Gene

ENSEMBL:
Gene Tree for EIF4EBP2 (if available)
TreeFam:
Gene Tree for EIF4EBP2 (if available)

Paralogs for EIF4EBP2 Gene

Paralogs for EIF4EBP2 Gene

Selected SIMAP similar genes for EIF4EBP2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF4EBP2 Gene

genes like me logo Genes that share paralogs with EIF4EBP2: view

Variants for EIF4EBP2 Gene

Sequence variations from dbSNP and Humsavar for EIF4EBP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1173 -- 70,425,838(-) TTTTC(C/T)TCAGC utr-variant-3-prime
rs7463 -- 70,427,038(+) TCTAG(C/G)ATAAC utr-variant-3-prime
rs7784 -- 70,428,433(+) TTCAC(C/T)GTGTG utr-variant-3-prime
rs9914 -- 70,423,275(-) GGAAA(G/T)AGCTC utr-variant-3-prime
rs14761 -- 70,423,219(-) CTTGC(C/T)TATGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF4EBP2 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407

Relevant External Links for EIF4EBP2 Gene

HapMap Linkage Disequilibrium report
EIF4EBP2

Disorders for EIF4EBP2 Gene

Relevant External Links for EIF4EBP2

Genetic Association Database (GAD)
EIF4EBP2
Human Genome Epidemiology (HuGE) Navigator
EIF4EBP2
genes like me logo Genes that share disorders with EIF4EBP2: view

No data available for UniProtKB/Swiss-Prot for EIF4EBP2 Gene

Publications for EIF4EBP2 Gene

  1. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. (PMID: 8975712) Tsukiyama-Kohara K. … Sonenberg N. (Genomics 1996) 2 3 23
  2. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. (PMID: 7935836) Pause A. … Sonenberg N. (Nature 1994) 2 3 4
  3. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. (PMID: 9465032) Burnett P.E. … Sabatini D.M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 23
  4. Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturation. (PMID: 9531283) Beretta L. … Sonenberg N. (J. Immunol. 1998) 3 23
  5. Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation. (PMID: 10092805) Grolleau A. … Beretta L. (J. Immunol. 1999) 3 23

Products for EIF4EBP2 Gene

Sources for EIF4EBP2 Gene

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