Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EIF4EBP2 Gene

protein-coding   GIFtS: 61
GCID: GC10P072163

Eukaryotic Translation Initiation Factor 4E Binding Protein...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Eukaryotic Translation Initiation Factor 4E Binding Protein 21 2     PHASII2
4E-BP22 3     Eukaryotic Translation Initiation Factor 4E-Binding Protein 22
EIF4E-Binding Protein 22 3     Phosphorylated, Heat And Acid Stable Regulated By Insulin Protein II2
4EBP22 5     

External Ids:    HGNC: 32891   Entrez Gene: 19792   Ensembl: ENSG000001487307   OMIM: 6022245   UniProtKB: Q135423   

Export aliases for EIF4EBP2 gene to outside databases

Previous GC identifers: GC10P070925 GC10P071250 GC10P072056 GC10P071508 GC10P071834 GC10P066157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EIF4EBP2 Gene:
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene
products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors
can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of
protein production through these gene products have been implicated in cell proliferation, cell differentiation
and viral infection. (provided by RefSeq, Oct 2008)

GeneCards Summary for EIF4EBP2 Gene:
EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2) is a protein-coding gene. Diseases associated with EIF4EBP2 include sleep apnea, and ovarian cancer. GO annotations related to this gene include eukaryotic initiation factor 4E binding. An important paralog of this gene is EIF4EBP1.

UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542
Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of
protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway

Gene Wiki entry for EIF4EBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF4EBP2 gene promoter:
         NRSF form 1   AP-2alpha isoform 2   AP-2alpha   MRF-2   NRSF form 2   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF4EBP2 promoter sequence
   Search Chromatin IP Primers for EIF4EBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF4EBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21-q22   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21-q22

EIF4EBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4EBP2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P072163:  view genomic region     (about GC identifiers)

Start:
72,163,861 bp from pter      End:
72,188,374 bp from pter
Size:
24,514 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 4E-binding protein 2  
Size: 120 amino acids; 12939 Da
Subunit: Nonphosphorylated EIF4EBP2 interacts with EIF4E
1 PDB 3D structure from and Proteopedia for EIF4EBP2:
3AM7 (3D)    

Explore the universe of human proteins at neXtProt for EIF4EBP2: NX_Q13542

Explore proteomics data for EIF4EBP2 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EIF4EBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004087.1  
    ENSEMBL proteins: 
     ENSP00000362314  

    EIF4EBP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for EIF4EBP2
    OriGene Protein Over-expression Lysate for EIF4EBP2
    OriGene MassSpec for EIF4EBP2
    OriGene Custom Protein Services for EIF4EBP2
    GenScript Custom Purified and Recombinant Proteins Services for EIF4EBP2
    Novus Biologicals EIF4EBP2 Proteins
    Novus Biologicals EIF4EBP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for EIF4EBP2
    Cloud-Clone Corp. Proteins for EIF4EBP2

    EIF4EBP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for EIF4EBP2  (4E-BP2)
    OriGene Antibodies for EIF4EBP2
    OriGene Custom Antibody Services for EIF4EBP2
    Novus Biologicals EIF4EBP2 Antibodies
    Abcam antibodies for EIF4EBP2
    Cloud-Clone Corp. Antibodies for EIF4EBP2
    ThermoFisher Antibody for EIF4EBP2
    LSBio Antibodies in human, mouse, rat for EIF4EBP2

    EIF4EBP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EIF4EBP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EIF4EBP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EIF4EBP2
    Cloud-Clone Corp. CLIAs for EIF4EBP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR008606 EIF4EBP

    Graphical View of Domain Structure for InterPro Entry Q13542

    ProtoNet protein and cluster: Q13542

    1 Blocks protein domain: IPB008606 Eukaryotic translation initiation factor 4E binding

    UniProtKB/Swiss-Prot: 4EBP2_HUMAN, Q13542
    Similarity: Belongs to the eIF4E-binding protein family


    EIF4EBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 4EBP2_HUMAN, Q13542
    Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of
    protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway

         Genatlas biochemistry entry for EIF4EBP2:
    eukaryotic translation initiation factor 4E,binding protein 2,implicated in the progression of cancer

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16271312
    GO:0008190eukaryotic initiation factor 4E binding IEA--
         
    EIF4EBP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EIF4EBP2:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Eif4ebp2):
     behavior/neurological  nervous system 

    EIF4EBP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Eif4ebp2tm1Klan for EIF4EBP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF4EBP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF4EBP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF4EBP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF4EBP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target EIF4EBP2:
    hsa-mir-760 (MIRT036785), hsa-let-7e-5p (MIRT051622), hsa-mir-877-3p (MIRT036867), hsa-mir-7-5p (MIRT025698), hsa-mir-375 (MIRT019719), hsa-mir-18a-5p (MIRT050703), hsa-mir-21-5p (MIRT030777)

    Block miRNA regulation of human, mouse, rat EIF4EBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF4EBP2 (see all 78):
    hsa-miR-3194-5p hsa-miR-200a hsa-miR-4267 hsa-miR-29a* hsa-miR-3909 hsa-miR-509-3-5p hsa-miR-30b* hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidEIF4EBP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EIF4EBP2
    Predesigned siRNA for gene silencing in human, mouse, rat EIF4EBP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EIF4EBP2

    Clone
    Products:
         
    OriGene clones in human, mouse for EIF4EBP2 (see all 6)
    OriGene ORF clones in mouse, rat for EIF4EBP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF4EBP2 (NM_004096)
    Sino Biological Human cDNA Clone for EIF4EBP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF4EBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4EBP2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EIF4EBP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for EIF4EBP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4EBP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EIF4EBP2 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    Regulation of eIF4 and p70S6K0.43
    2Beta-Adrenergic Signaling
    Insulin Receptor Pathway0.37
    3Translational Control
    Translational Control
    4Translation Factors
    Translation Factors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF4EBP2
        Regulation of eIF4 and p70S6K
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF4EBP2
        Translational Control

    1 BioSystems Pathway for EIF4EBP2
        Translation Factors




    EIF4EBP2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including EIF4EBP2: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EIF4EBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF4EBP2 (Q135422, 3 ENSP000003623144) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4EP067302, 3, ENSP000002808924MINT-19025 I2D: score=6 STRING: ENSP00000280892
    UNKLENSP000003017124STRING: ENSP00000384850 STRING: ENSP00000301712
    CREBBPENSP000002623674STRING: ENSP00000262367
    COPS4ENSP000002643894STRING: ENSP00000264389
    IBTKENSP000003057214STRING: ENSP00000305721
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS7935836
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0019933cAMP-mediated signaling IEA--
    GO:0045947negative regulation of translational initiation IEA--

    EIF4EBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF4EBP2 (4EBP2)

    2 Novoseek inferred chemical compound relationships for EIF4EBP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 54.4 1 20347422 (1)
    retinoic acid 26.2 6 11069026 (3), 10092805 (1)



    EIF4EBP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EIF4EBP2 gene: 
    NM_004096.4  

    Unigene Cluster for EIF4EBP2:

    Eukaryotic translation initiation factor 4E binding protein 2
    Hs.621200  [show with all ESTs]
    Unigene Representative Sequence: NM_004096
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373218(uc001jrb.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EIF4EBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF4EBP2 (see all 78):
    hsa-miR-3194-5p hsa-miR-200a hsa-miR-4267 hsa-miR-29a* hsa-miR-3909 hsa-miR-509-3-5p hsa-miR-30b* hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidEIF4EBP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EIF4EBP2
    Predesigned siRNA for gene silencing in human, mouse, rat EIF4EBP2
    Clone
    Products:
         
    OriGene clones in human, mouse for EIF4EBP2 (see all 6)
    OriGene ORF clones in mouse, rat for EIF4EBP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF4EBP2 (NM_004096)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF4EBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4EBP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EIF4EBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF4EBP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF4EBP2
      QuantiTect SYBR Green Assays in human, mouse, rat EIF4EBP2
      QuantiFast Probe-based Assays in human, mouse, rat EIF4EBP2

    Additional mRNA sequence: 

    AK001936.1 AK057643.1 AK313724.1 BC005057.1 BC050633.1 BT007317.1 CR542240.1 CR627373.1 
    L36056.1 

    19 DOTS entries:

    DT.95274108  DT.449454  DT.100819197  DT.100655113  DT.100692498  DT.100819206  DT.100674359  DT.100739373 
    DT.92457651  DT.95153802  DT.121272024  DT.100819199  DT.121271907  DT.92445281  DT.92457645  DT.95153798 
    DT.95153800  DT.95084454  DT.95153808 

    Selected AceView cDNA sequences (see all 664):

    BF478028 AA491499 BM806740 BM562738 AA487457 BG430823 AA701298 BU188949 
    CA419743 BU956663 CA440031 AJ573247 AA757533 BE296568 CR611424 BE219517 
    BM710817 W84449 BM696421 AI874393 CR610579 AI783514 BQ446757 AL583350 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EIF4EBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAGTTGTT
    EIF4EBP2 Expression
    About this image


    EIF4EBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             Mandibular Arch Muscles
     
     Adipose (Muscoskeletal System)
    EIF4EBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF4EBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.621200
        Pathway & Disease-focused RT2 Profiler PCR Array including EIF4EBP2: 
              mTOR Signaling in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EIF4EBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF4EBP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF4EBP2
    QuantiTect SYBR Green Assays in human, mouse, rat EIF4EBP2
    QuantiFast Probe-based Assays in human, mouse, rat EIF4EBP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4EBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for EIF4EBP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif4ebp21 , 5 eukaryotic translation initiation factor 4E binding more1, 5 91.39(n)1
    95(a)1
      10 (32.21 cM)5
    136881  NM_010124.21  NP_034254.11 
     614324975 
    lizard
    (Anolis carolinensis)
    Reptilia EIF4EBP26
    eukaryotic translation initiation factor 4E bindin...
    81(a)
    1 ↔ 1
    3(50947915-50969657)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.191192 Xenopus laevis, Similar to eukaryotic translation initiation more 81.79(n)    BC047251.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufp45e092 wufp45e09 75.8(n)   386945  CD583784.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Thor6
    Thor
    38(a)
    1 → many
    2L(3478434-3479612)


    ENSEMBL Gene Tree for EIF4EBP2 (if available)
    TreeFam Gene Tree for EIF4EBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EIF4EBP2 gene
    EIF4EBP12  EIF4EBP32  
    2 SIMAP similar genes for EIF4EBP2 using alignment to 2 protein entries:     4EBP2_HUMAN (see all proteins):
    EIF4EBP3    EIF4EBP1

    EIF4EBP2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for EIF4EBP2
    PGOHUM00000246762 PGOHUM00000247538 PGOHUM00000243304


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EIF4EBP2 (see all 498)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745343421,2
    C,F--72161993(+) TCGTAG/ACTCAC 1 -- us2k12Minor allele frequency- A:0.07CSA WA 120
    rs1891057361,2
    --72162055(+) GTAGGC/TTGGGA 1 -- us2k10--------
    rs1814426621,2
    --72162064(+) GACTAC/TAGGTG 1 -- us2k10--------
    rs1858815531,2
    --72162082(+) CCATGC/TCTGGA 1 -- us2k10--------
    rs744724091,2
    C--72162087(+) TCTGGA/TTAATT 1 -- us2k10--------
    rs757777431,2
    C,F--72162137(+) GTCTCG/ACTTTT 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1425121281,2
    --72162511(+) TGTCTA/GTGTTC 1 -- us2k10--------
    rs1460948341,2
    --72162556(+) AGCAAC/TAGCTG 1 -- us2k10--------
    rs618581011,2
    C--72162596(+) TCTCTC/AATTTG 1 -- us2k12Minor allele frequency- A:0.03NA 122
    rs743462021,2
    C,F--72162729(+) GAGAGC/TCCCTC 1 -- us2k12Minor allele frequency- T:0.10WA EA 238

    HapMap Linkage Disequilibrium report for EIF4EBP2 (72163861 - 72188374 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EIF4EBP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv32737CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF4EBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF4EBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602224    OMIM disorders: --

    5 diseases for EIF4EBP2:    
    About MalaCards
    sleep apnea    ovarian cancer    alzheimer's disease    breast cancer
    thyroiditis


    EIF4EBP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EIF4EBP2
    Human Genome Epidemiology (HuGE) Navigator: EIF4EBP2 (8 documents)

    Export disorders for EIF4EBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EIF4EBP2 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with EIF4EBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. (PubMed id 7935836)1, 2, 3 Pause A.... Sonenberg N. (Nature 1994)
    2. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. (PubMed id 8975712)1, 3, 9 Tsukiyama-Kohara K....Sonenberg N. (Genomics 1996)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Defect in the regulation of 4E-BP1 and 2, two repressors of translation initiation, in the retinoid acid resistant cell lines, NB4-R1 and NB4-R2. (PubMed id 11069026)1, 9 Grolleau A....Beretta L. (Leukemia 2000)
    8. Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation. (PubMed id 10092805)1, 9 Grolleau A....Beretta L. (J. Immunol. 1999)
    9. Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis. (PubMed id 17316564)1, 9 Abiko F....Ishida T. (Biochem. Biophys. Res. Commun. 2007)
    10. Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturation. (PubMed id 9531283)1, 9 Beretta L....Sonenberg N. (J. Immunol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1979 HGNC: 3289 AceView: EIF4EBP2 Ensembl:ENSG00000148730 euGenes: HUgn1979
    ECgene: EIF4EBP2 H-InvDB: EIF4EBP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EIF4EBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EIF4EBP2 gene:
    Search GeneIP for patents involving EIF4EBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EIF4EBP2   OriGene RNAi products in human, mouse, rat for EIF4EBP2  
     OriGene qPCR primer pairs and template standards for EIF4EBP2   OriGene Protein Over-expression Lysate for EIF4EBP2  
     OriGene MassSpec something-or-other for EIF4EBP2   OriGene clones in human, mouse for EIF4EBP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for EIF4EBP2   OriGene Purified Protein for EIF4EBP2  
     OriGene ORF clones in mouse, rat for EIF4EBP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EIF4EBP2   OriGene Custom Protein Services for EIF4EBP2  

     
     
     Block miRNA regulation of human, mouse, rat EIF4EBP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EIF4EBP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF4EBP2 Predesigned siRNA for gene silencing in human, mouse, rat EIF4EBP2
     QuantiFast Probe-based Assays in human, mouse, rat EIF4EBP2 QuantiTect SYBR Green Assays in human, mouse, rat EIF4EBP2
     PCR Arrays including human, mouse, rat EIF4EBP2 Search Chromatin IP Primers for EIF4EBP2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF4EBP2  GeneGlobe Interaction Network for EIF4EBP2
     Regulatory tfbs in EIF4EBP2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EIF4EBP2 GenScript cDNA clones with any tag delivered in your preferred vector for EIF4EBP2
     GenScript Custom Assay Services for EIF4EBP2 GenScript Custom overexpressing Cell Line Services for EIF4EBP2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for EIF4EBP2  (4E-BP2)

     Search Tocris compounds for EIF4EBP2 (4EBP2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for EIF4EBP2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EIF4EBP2 antibodies
     EIF4EBP2 proteins
     EIF4EBP2 lysates
     Antibodies for EIF4EBP2
     See all of Abcam's Antibodies, Kits and Proteins for EIF4EBP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for EIF4EBP2
     Proteins for EIF4EBP2
     Antibodies for EIF4EBP2
     ELISAs for EIF4EBP2
     CLIAs for EIF4EBP2



     Browse ESI BIO Cell Lines and PureStem Progenitors for EIF4EBP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4EBP2
     SwitchGear 3'UTR luciferase reporter plasmids for EIF4EBP2
     SwitchGear Promoter luciferase reporter plasmids for EIF4EBP2
     ThermoFisher Antibody for EIF4EBP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4EBP2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF4EBP2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF4EBP2
     LSBio Antibodies in human, mouse, rat for EIF4EBP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EIF4EBP2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4