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Aliases for EIF4EBP1 Gene

Aliases for EIF4EBP1 Gene

  • Eukaryotic Translation Initiation Factor 4E Binding Protein 1 2 3 5
  • Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 2 3 4
  • EIF4E-Binding Protein 1 3 4
  • 4E-BP1 3 4
  • PHAS-I 3 4
  • Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 3
  • 4EBP1 3
  • BP-1 3

External Ids for EIF4EBP1 Gene

Previous GeneCards Identifiers for EIF4EBP1 Gene

  • GC04P9B0162
  • GC04M9B0161
  • GC08M9E0078
  • GC08P037888
  • GC08P036422

Summaries for EIF4EBP1 Gene

Entrez Gene Summary for EIF4EBP1 Gene

  • This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

GeneCards Summary for EIF4EBP1 Gene

EIF4EBP1 (Eukaryotic Translation Initiation Factor 4E Binding Protein 1) is a Protein Coding gene. Diseases associated with EIF4EBP1 include Tracheal Cancer and Tuberous Sclerosis-1. Among its related pathways are mTOR signaling pathway (KEGG) and Translation Insulin regulation of translation. GO annotations related to this gene include translation initiation factor binding and eukaryotic initiation factor 4E binding. An important paralog of this gene is EIF4EBP2.

UniProtKB/Swiss-Prot for EIF4EBP1 Gene

  • Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Gene Wiki entry for EIF4EBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4EBP1 Gene

Genomics for EIF4EBP1 Gene

Regulatory Elements for EIF4EBP1 Gene

Enhancers for EIF4EBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F038764 1.2 FANTOM5 Ensembl ENCODE 15.2 +738.1 738056 7.5 HDGF PKNOX1 WRNIP1 SIN3A ARID4B YBX1 FEZF1 ZNF2 YY1 ZNF766 TACC1 ENSG00000255201 ADAM5 ADAM3A LOC100130964 LETM2 EIF4EBP1 FGFR1 DDHD2 PLEKHA2
GH08F037848 0.2 ENCODE 12.3 -180.6 -180563 2.5 PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC100507403 BRF2 EIF4EBP1 ENSG00000254290 GC08P037836
GH08F037779 0.5 Ensembl ENCODE 12.3 -246.1 -246129 9.5 HDGF PKNOX1 ARNT WRNIP1 SIN3A ARID4B FEZF1 DMAP1 YBX1 ZNF2 ENSG00000254306 EIF4EBP1 LOC100507403 ENSG00000255201 ADGRA2 LOC105379381
GH08F038910 1.4 FANTOM5 Ensembl ENCODE 12.3 +882.3 882322 5.3 HDGF ATF1 PKNOX1 ZNF493 ARID4B GLI4 YBX1 ZNF2 YY1 ZNF302 ADAM5 ADAM3A LOC100130964 IDO1 EIF4EBP1 ENSG00000253645 HTRA4 TM2D2 ADAM9 DDHD2
GH08F037993 0.5 ENCODE 12 -36.5 -36454 0.2 CTCF ZNF2 RAD21 ZNF324 ZNF335 GATAD1 EED ZNF143 SMC3 PRDM10 EIF4EBP1 GOT1L1 RAB11FIP1 RNU6-323P GC08P037988
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EIF4EBP1 on UCSC Golden Path with GeneCards custom track

Promoters for EIF4EBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001440554 359 2601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 KLF13 ZNF263

Genomic Location for EIF4EBP1 Gene

Chromosome:
8
Start:
38,030,341 bp from pter
End:
38,060,365 bp from pter
Size:
30,025 bases
Orientation:
Plus strand

Genomic View for EIF4EBP1 Gene

Genes around EIF4EBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4EBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4EBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4EBP1 Gene

Proteins for EIF4EBP1 Gene

  • Protein details for EIF4EBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13541-4EBP1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E-binding protein 1
    Protein Accession:
    Q13541
    Secondary Accessions:
    • B2R502
    • D3DSW8
    • Q6IBN3

    Protein attributes for EIF4EBP1 Gene

    Size:
    118 amino acids
    Molecular mass:
    12580 Da
    Quaternary structure:
    • Hypophosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1 (PubMed:12747827).

    Three dimensional structures from OCA and Proteopedia for EIF4EBP1 Gene

neXtProt entry for EIF4EBP1 Gene

Post-translational modifications for EIF4EBP1 Gene

  • Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
  • Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.
  • Ubiquitination at Lys 57
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF4EBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF4EBP1 Gene

Domains & Families for EIF4EBP1 Gene

Protein Domains for EIF4EBP1 Gene

Suggested Antigen Peptide Sequences for EIF4EBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13541

UniProtKB/Swiss-Prot:

4EBP1_HUMAN :
  • The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.
  • Belongs to the eIF4E-binding protein family.
Domain:
  • The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.
Family:
  • Belongs to the eIF4E-binding protein family.
genes like me logo Genes that share domains with EIF4EBP1: view

No data available for Gene Families for EIF4EBP1 Gene

Function for EIF4EBP1 Gene

Molecular function for EIF4EBP1 Gene

GENATLAS Biochemistry:
eukaryotic translation initiation factor 4E,binding protein 1,implicated in the progression of cancer
UniProtKB/Swiss-Prot Function:
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Gene Ontology (GO) - Molecular Function for EIF4EBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7651417
GO:0008190 eukaryotic initiation factor 4E binding IDA 23814182
GO:0030371 translation repressor activity IDA 22578813
GO:0031369 translation initiation factor binding IEA --
GO:0051721 protein phosphatase 2A binding IEA --
genes like me logo Genes that share ontologies with EIF4EBP1: view
genes like me logo Genes that share phenotypes with EIF4EBP1: view

Animal Models for EIF4EBP1 Gene

MGI Knock Outs for EIF4EBP1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF4EBP1 Gene

Localization for EIF4EBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4EBP1 Gene COMPARTMENTS Subcellular localization image for EIF4EBP1 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3
extracellular 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EIF4EBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with EIF4EBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4EBP1 Gene

Pathways & Interactions for EIF4EBP1 Gene

genes like me logo Genes that share pathways with EIF4EBP1: view

SIGNOR curated interactions for EIF4EBP1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF4EBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 14673156
GO:0002192 IRES-dependent translational initiation IEA --
GO:0002931 response to ischemia IEA --
GO:0006417 regulation of translation IEA --
GO:0008286 insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with EIF4EBP1: view

Drugs & Compounds for EIF4EBP1 Gene

(29) Drugs for EIF4EBP1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0

(18) Additional Compounds for EIF4EBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for EIF4EBP1 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
genes like me logo Genes that share compounds with EIF4EBP1: view

Transcripts for EIF4EBP1 Gene

mRNA/cDNA for EIF4EBP1 Gene

Unigene Clusters for EIF4EBP1 Gene

Eukaryotic translation initiation factor 4E binding protein 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4EBP1 Gene

No ASD Table

Relevant External Links for EIF4EBP1 Gene

GeneLoc Exon Structure for
EIF4EBP1
ECgene alternative splicing isoforms for
EIF4EBP1

Expression for EIF4EBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4EBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF4EBP1 Gene

This gene is overexpressed in Pancreas (x6.6).

Protein differential expression in normal tissues from HIPED for EIF4EBP1 Gene

This gene is overexpressed in Pancreas (20.7), Skin (14.7), and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF4EBP1 Gene



Protein tissue co-expression partners for EIF4EBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF4EBP1 Gene:

EIF4EBP1

SOURCE GeneReport for Unigene cluster for EIF4EBP1 Gene:

Hs.411641
genes like me logo Genes that share expression patterns with EIF4EBP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for EIF4EBP1 Gene

Orthologs for EIF4EBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF4EBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4EBP1 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia EIF4EBP1 34 35
  • 92.94 (n)
rat
(Rattus norvegicus)
Mammalia Eif4ebp1 34
  • 90.88 (n)
mouse
(Mus musculus)
Mammalia Eif4ebp1 34 16 35
  • 90.6 (n)
cow
(Bos Taurus)
Mammalia EIF4EBP1 34 35
  • 89.83 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF4EBP1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4EBP1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4EBP1 34 35
  • 66.96 (n)
lizard
(Anolis carolinensis)
Reptilia EIF4EBP1 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii eif4ebp1 34 35
  • 60.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Thor 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5022 35
  • 18 (a)
OneToMany
Species where no ortholog for EIF4EBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4EBP1 Gene

ENSEMBL:
Gene Tree for EIF4EBP1 (if available)
TreeFam:
Gene Tree for EIF4EBP1 (if available)

Paralogs for EIF4EBP1 Gene

Paralogs for EIF4EBP1 Gene

(2) SIMAP similar genes for EIF4EBP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for EIF4EBP1 Gene

genes like me logo Genes that share paralogs with EIF4EBP1: view

Variants for EIF4EBP1 Gene

Sequence variations from dbSNP and Humsavar for EIF4EBP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10106996 -- 38,048,048(-) ctcaa(A/G)tgatc intron-variant
rs1048925 -- 38,060,099(+) CTCCT(C/T)TTCGT utr-variant-3-prime
rs1048934 -- 38,060,267(+) GGGGG(C/T)GCAAC utr-variant-3-prime
rs111227978 -- 38,036,802(+) CACCA(C/T)CACAA intron-variant
rs111313394 -- 38,059,487(+) TGGCT(C/T)GCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4EBP1 Gene

Variant ID Type Subtype PubMed ID
esv3616914 CNV loss 21293372
nsv610947 CNV loss 21841781
nsv824600 CNV gain 20364138

Variation tolerance for EIF4EBP1 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4EBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4EBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4EBP1 Gene

Disorders for EIF4EBP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for EIF4EBP1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
tracheal cancer
  • ca trachea
tuberous sclerosis-1
  • tuberous sclerosis
large intestine adenocarcinoma
  • adenocarcinoma of large intestine
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EIF4EBP1

Genetic Association Database (GAD)
EIF4EBP1
Human Genome Epidemiology (HuGE) Navigator
EIF4EBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4EBP1
genes like me logo Genes that share disorders with EIF4EBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4EBP1 Gene

Publications for EIF4EBP1 Gene

  1. Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes. (PMID: 18442140) Soma H. … Sasaki H. (Mov. Disord. 2008) 3 22 46 64
  2. Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. (PMID: 16271312) Tomoo K. … Ishida T. (Biochim. Biophys. Acta 2005) 3 4 22 64
  3. The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. (PMID: 12588975) Wang X. … Proud C.G. (Mol. Cell. Biol. 2003) 3 4 22 64
  4. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. (PMID: 12150926) Hara K. … Yonezawa K. (Cell 2002) 3 4 22 64
  5. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. (PMID: 9465032) Burnett P.E. … Sabatini D.M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 22 64

Products for EIF4EBP1 Gene

Sources for EIF4EBP1 Gene

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