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EIF4EBP1 Gene

protein-coding GIFtS: 68

GC08P038007

eukaryotic translation initiation factor 4E binding protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
4E-BP1 ^¹, ², ³
4EBP1 ^², ⁵
BP-1 ^²
MGC4316 ^²
PHAS-I ^¹, ², ³

Descriptions
Phosphorylated heat- and acid-stable protein regulated by insulin 1 ^², ³
eIF4E-binding protein 1 ^², ³
eukaryotic translation initiation factor 4E binding protein 1 ^²

External Ids
HGNC: 3288¹
Entrez Gene: 1978²
UniProtKB: Q13541³
Ensembl: ENSG00000187840⁷

Search outside databases for aliases for EIF4EBP1 gene

Previous GC identifers: GC04P9B0162 GC04M9B0161 GC08M9E0078

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for EIF4EBP1:

This gene encodes one member of a family of translation repressor proteins. The protein directly

interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component

of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs.

Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This

protein is phosphorylated in response to various signals including UV irradiation and insulin

signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided

by RefSeq]

UniProtKB/Swiss-Prot: 4EBP1_HUMAN, Q13541

Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the

regulation of protein translation by hormones, growth factors and other stimuli that signal

through the MAP kinase pathway

Gene Wiki entry for EIF4EBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EIF4EBP1 gene

Entrez Gene cytogenetic band: 8p12 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p12

EIF4EBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P038007: (about GC identifiers)

Start:	38,007,177 bp from pter
End:	38,037,040 bp from pter
Size:	29,864 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_007995.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: 4EBP1_HUMAN, Q13541 (See protein sequence)

Recommended Name: Eukaryotic translation initiation factor 4E-binding protein 1

Size: 118 amino acids; 12580 Da

Subunit: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin

stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the

complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can

attenuate insulin stimulation, mediated by FKBPs

PDB structures from and Proteopedia :

1WKW (3D)

2JGB (3D)

2JGC (3D)

2V8W (3D)

2V8X (3D)

2V8Y (3D)

Secondary accessions: Q6IBN3

Post-translational modifications:

Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF.

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004086.1

ENSEMBL proteins:

ENSP00000340691

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for EIF4EBP1
	Recombinant Proteins from Abcam (eIF4EBP1 + eIF4EBP2 + eIF4EBP3, eIF4EBP1)
	Human Recombinant Proteins from Abnova (EIF4EBP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	EXP	7935836 15809305

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Antibodies for EIF4EBP1:

	Invitrogen Antibodies for EIF4EBP1
	Millipore Mono- and Polyclonal Antibodies for the study of EIF4EBP1
	Sigma-Aldrich Antibodies for EIF4EBP1
	R&D Systems Antibodies for EIF4EBP1 (4EBP1)
	Cell Signaling Technology (CST) Antibodies for EIF4EBP1 (4E-BP1)
	Antibodies from Abcam (eIF4EBP1 + eIF4EBP2 + eIF4EBP3, eIF4EBP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EIF4EBP1)
	Novus Biologicals Antibodies for EIF4EBP1

Assays for EIF4EBP1:

	Invitrogen Assays for EIF4EBP1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Cell Signaling Technology (CST) Sandwich ELISA Kits for EIF4EBP1 (4E-BP1)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13541

ProtoNet protein and cluster: Q13541

1 Blocks protein family: IPB008606 Eukaryotic translation initiation factor 4E binding

UniProtKB/Swiss-Prot: 4EBP1_HUMAN, Q13541

Similarity: Belongs to the eIF4E-binding protein family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EIF4EBP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EIF4EBP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004095

Applied Biosystems Silencer® siRNAs for EIF4EBP1

Sigma-Aldrich siRNA for EIF4EBP1

Sigma-Aldrich shRNA for EIF4EBP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EIF4EBP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004095
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004095
untagged cDNA clone in CMV expression vector: NM_004095

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004095

UniProtKB/Swiss-Prot: 4EBP1_HUMAN, Q13541

Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the

regulation of protein translation by hormones, growth factors and other stimuli that signal

through the MAP kinase pathway

Genatlas biochemistry entry for EIF4EBP1:

eukaryotic translation initiation factor 4E,binding protein 1,implicated in the progression of

cancer

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Eif4ebp1):

adipose tissue

cellular

growth/size

homeostasis/metabolism

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15094042 15153109 17353931
GO:0008190	eukaryotic initiation factor 4E binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for EIF4EBP1 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Insulin Receptor Signaling
ERK/MAPK Signaling
IL-8 Signaling
Acute Myeloid Leukemia Signaling
FLT3 Signaling in Hematopoietic Progenitor Cells

GeneDecks EIF4EBP1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for EIF4EBP1

5/42 Interacting proteins for EIF4EBP1 (ENSP00000340691³ Q13541^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIAA1303	Q8N122²	STRING (score=.999) MINT-6549354
EIF4E	P06730¹^,²	STRING (score=.999) EBI-74090, EBI-73440 MINT-68432 MINT-1788697 MINT-19057 MINT-19056 EBI-74090, EBI-73440 MINT-68432 MINT-1788697 MINT-19057 MINT-19056
EIF4E2	O60573¹	EBI-74090, EBI-398610
UBAC1	Q9BSL1¹	EBI-74090, EBI-749370
Eif4e2 Eif4e2 (xeno)	Q80ZJ3¹	EBI-74090, EBI-934970

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008286	insulin receptor signaling pathway	IEA	--
GO:0045947	negative regulation of translational initiation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EIF4EBP1
10/24 Novoseek chemical compound relationships for EIF4EBP1 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
m7gtp	83.92	10	10772338 (3), 10864916 (1), 17440067 (1), 9504423 (1) (see all 5)
wortmannin	73.24	26	8633019 (2), 10580837 (2), 9468502 (1), 9160663 (1) (see all 18)
phosphatidylinositol	67.18	17	18810319 (2), 9468502 (1), 10681523 (1), 15520204 (1) (see all 13)
phosphoinositide	57.07	3	14769825 (1), 12529177 (1)
threonine	50.66	10	14522890 (1), 9204908 (1), 9020107 (1), 9472019 (1) (see all 7)
pd 98,059	49.19	4	11023817 (1), 11855825 (1), 11777913 (1), 16990847 (1)
leucine	49.05	20	10723090 (3), 9774438 (2), 9814971 (2), 10206976 (1) (see all 13)
ifn-alpha	36.48	5	17114181 (2), 15056668 (1), 15790787 (1)
alpha-ketoisocaproate	36.25	1	9774438 (1)
okadaic acid	33.17	7	9248697 (2), 10893325 (1), 10504405 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EIF4EBP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EIF4EBP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004095

Sigma-Aldrich siRNA for EIF4EBP1

Sigma-Aldrich shRNA for EIF4EBP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004095

REFSEQ mRNAs for EIF4EBP1 gene:

NM_004095.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004095

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004095
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004095
                                 untagged cDNA clone in CMV expression vector: NM_004095

Additional cDNA sequence:

AB044548.1 AK312011.1 BC004459.1 BC058073.1 BT007162.1 CR456769.1 L36055.1

7 DOTS entries:

DT.445314 DT.100785084 DT.121465783 DT.95318728 DT.100785083 DT.92437830 DT.97825318

24/220 AceView cDNA sequences (see all 220 ):

BE781403 BG033923 AI571181 BM552477 BG761376 BG251612 BM701955 AI199543

BC004459 BM853796 BG574763 NM_004095 CA427014 BP379870 BE794824 BC058073

AB044548 L36055 BM014495 CB105930 AI341842 BM795375 BI861025 BE795061

highest scoring ESTs for EIF4EBP1:

AI026669 L36055 AA147340 AA147371 AA290674 AA291063 AA401092 AA418646 AA643157 AA676503

Unigene Cluster for EIF4EBP1:

Eukaryotic translation initiation factor 4E binding protein 1

Hs.411641 [show with all ESTs]

Unigene Representative Sequence: BM564526

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000338825

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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EIF4EBP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EIF4EBP1

¹ / ² / ³

4 probe-sets matching EIF4EBP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54152_at²^{, 3}	U95-B	1	1.00	1.00	0.98	1.06	AI026669	1.00	1.00	1.00	1
31597_r_at²^{, 3}	U95-A	2	1.00	0.97	0.99	0.95	L36055	1.00	1.00	1.00	1
221539_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB044548	0.80	1.00	0.91	1
221539_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EIF4EBP1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAGCCAGCC

SOURCE GeneReport for Unigene cluster: Hs.411641
Expression variation in blood from EXPOLDB for EIF4EBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EIF4EBP1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EIF4EBP1¹	--	eukaryotic translation initiation factor 4E binding more	92.94(n) 94.92(a)	475590 XM_549448.2 XP_549448.2
chimpanzee (Pan troglodytes)	EIF4EBP1¹	--	eukaryotic translation initiation factor 4E binding more	99.44(n) 100(a)	464114 XM_531121.2 XP_531121.2
cow (Bos taurus)	EIF4EBP1¹	--	eukaryotic translation initiation factor 4E binding more	87.92(n) 86.96(a)	509613 XM_001251485.1 XP_001251486.1
rat (Rattus norvegicus)	Eif4ebp1¹	--	eukaryotic translation initiation factor 4E binding more	90.88(n) 93.16(a)	116636 NM_053857.1 NP_446309.1
mouse (Mus musculus)	Eif4ebp1^{1, 5}	8 (8.00 cM)⁵	eukaryotic translation initiation factor 4E binding more^{1, 5}	90.6(n)¹ 91.45(a)¹	13685¹ NM_007918.3¹ NP_031944.3¹ AA959816⁵ AK013033⁵ (see all 12)

About this table Species with no ortholog for EIF4EBP1

ENSEMBL Gene Tree for EIF4EBP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EIF4EBP1 gene

EIF4EBP2²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/107 NCBI SNPs in EIF4EBP1 are shown (see all 107 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 17)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3813521^1,2	C,F	38006579(+)	`ACCTCC/TGCGCC`	1	--	ng5¹		1		EA	1304
--	rs9692998^1,2	C	38005267(-)	`aagatA/Ggtgaa`	1	--	ng5¹		0	--	--	--	--
	rs1048934^1,2	C	38036942(+)	`GGGGGC/G/TGCAAC`	1	--	ut3¹		0	--	--	--	--
--	rs13260728^1,2	C	38037211(-)	`aacccA/Gggagg`	1	--	ng3¹		0	--	--	--	--
--	rs3750243^1,2	F	38007174(+)	`GGCGGG/CACGGG`	1	--	ng5¹		1		EA	738
	rs6605631^1,2	A,C,F	38021610(-)	`CAATCA/GTTGCC`	1	--	int¹		8		EA NA	576
--	rs6994465^1,2	A,C,F	38008650(-)	`CGGGAA/GTGGCA`	1	--	int¹		3		NA	142
	rs28570677^1,2	C,F	38027971(+)	`CTCCTG/TTACTT`	1	--	int¹		2		EA	180
--	rs7819149^1,2	A	38010444(-)	`actccA/Gtctca`	1	--	int¹		0	--	--	--	--
--	rs6605632^1,2	C	38021262(-)	`atggcA/Gtgcgc`	1	--	int¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for EIF4EBP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602223

10/30 Novoseek disease relationships for EIF4EBP1 gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tuberous sclerosis	60.82	1	12384518 (1)
ataxia telangiectasia	40.28	3	11114166 (1), 11146653 (1)
tumors	37.89	40	19251093 (5), 18708753 (2), 16375881 (2), 15501954 (2) (see all 20)
cancer	36.70	12	16652388 (3), 17230506 (1), 17440067 (1), 18644990 (1) (see all 7)
rhabdomyosarcoma	36.47	5	11410517 (2), 18708753 (1), 17585318 (1), 15735038 (1)
glioblastoma	28.08	2	19251093 (1)
hyperinsulinemia	27.43	4	11134159 (2), 12169454 (1), 7629182 (1)
retinoblastoma	25.87	1	11426655 (1)
myeloid leukemia chronic	24.26	1	14522890 (1)
lymphoma	23.88	2	19176054 (1), 15010827 (1)

About this table

Human Genome Epidemiology Navigator: EIF4EBP1 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/376 PubMed articles for EIF4EBP1 gene (see all 376 ):

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. (PubMed id 7935836)^{2, 3, 4} Pause A.... Sonenberg N. (1994)
Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. (PubMed id 16271312)^{1, 3, 4} Tomoo K....Ishida T. (2005)
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor- 4E. (PubMed id 8521827)^{1, 3, 4} Haghighat A.... Sonenberg N. (1995)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor. (PubMed id 12665511)^{1, 3} Choi K.M....Lawrence J.C. (2003)
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. (PubMed id 11777913)^{1, 3} Liu G....Dong Z. (2002)
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. (PubMed id 10364159)^{1, 3} Gingras A.C....Sonenberg N. (1999)
Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1. (PubMed id 18810319)^{1, 3} Azar R....Pyronnet S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1978	HGNC: 3288	AceView: EIF4EBP1	Ensembl:ENSG00000187840	euGenes: HUgn1978
ECgene: EIF4EBP1	H-InvDB: EIF4EBP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EIF4EBP1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for EIF4EBP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for EIF4EBP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EIF4EBP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EIF4EBP1		Antibodies for EIF4EBP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EIF4EBP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EIF4EBP1)
	Antibodies (EIF4EBP1)
	Chimera RNAi (EIF4EBP1)
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Antibodies & Assays for EIF4EBP1 (4E-BP1)

	Recombinant Proteins (eIF4EBP1 + eIF4EBP2 + eIF4EBP3, eIF4EBP1)
	Antibodies (eIF4EBP1 + eIF4EBP2 + eIF4EBP3, eIF4EBP1)

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	Proteins for EIF4EBP1
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Antibodies for EIF4EBP1

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EIF4EBP1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for EIF4EBP1

Summaries
for EIF4EBP1

Genomic Location
for EIF4EBP1

Proteins
for EIF4EBP1

Protein Domains/
Families
for EIF4EBP1

Gene Function
for EIF4EBP1

Pathways & Interactions
for EIF4EBP1

Drugs & Compounds
for EIF4EBP1

Transcripts
for EIF4EBP1

Expression
for EIF4EBP1

Orthologs
for EIF4EBP1

Paralogs
for EIF4EBP1

SNPs/Variants
for EIF4EBP1

Disorders & Mutations
for EIF4EBP1

Medical News
for EIF4EBP1

Publications
for EIF4EBP1

Search for EIF4EBP1

Genome Databases showing EIF4EBP1

Other Databases showing EIF4EBP1

Specialized Databases showing EIF4EBP1

Licensable Technologies
for EIF4EBP1

Services
for EIF4EBP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EIF4EBP1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor EIF4EBP1

Summariesfor EIF4EBP1

Genomic Locationfor EIF4EBP1

Proteinsfor EIF4EBP1

Protein Domains/Familiesfor EIF4EBP1

Gene Functionfor EIF4EBP1

Pathways & Interactionsfor EIF4EBP1

Drugs & Compoundsfor EIF4EBP1

Transcriptsfor EIF4EBP1

Expression for EIF4EBP1

Orthologsfor EIF4EBP1

Paralogsfor EIF4EBP1

SNPs/Variantsfor EIF4EBP1

Disorders & Mutationsfor EIF4EBP1

Medical Newsfor EIF4EBP1

Publicationsfor EIF4EBP1

Search for EIF4EBP1

Genome Databases showing EIF4EBP1

Other Databases showing EIF4EBP1

Specialized Databases showing EIF4EBP1

Licensable Technologiesfor EIF4EBP1

Servicesfor EIF4EBP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EIF4EBP1

Summaries
for EIF4EBP1

Genomic Location
for EIF4EBP1

Proteins
for EIF4EBP1

Protein Domains/
Families
for EIF4EBP1

Gene Function
for EIF4EBP1

Pathways & Interactions
for EIF4EBP1

Drugs & Compounds
for EIF4EBP1

Transcripts
for EIF4EBP1

Expression
for EIF4EBP1

Orthologs
for EIF4EBP1

Paralogs
for EIF4EBP1

SNPs/Variants
for EIF4EBP1

Disorders & Mutations
for EIF4EBP1

Medical News
for EIF4EBP1

Publications
for EIF4EBP1

Licensable Technologies
for EIF4EBP1

Services
for EIF4EBP1