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Aliases for EIF4E3 Gene

Aliases for EIF4E3 Gene

  • Eukaryotic Translation Initiation Factor 4E Family Member 3 2 3 5
  • EIF-4E3 3 4
  • EIF4E-3 3 4
  • Eukaryotic Translation Initiation Factor 4E Member 3 2
  • Eukaryotic Translation Initiation Factor 4E Type 3 3
  • EIF-4E Type 3 4
  • EIF4E Type 3 4

External Ids for EIF4E3 Gene

Previous GeneCards Identifiers for EIF4E3 Gene

  • GC03U900551
  • GC03M071814

Summaries for EIF4E3 Gene

Entrez Gene Summary for EIF4E3 Gene

  • EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]

GeneCards Summary for EIF4E3 Gene

EIF4E3 (Eukaryotic Translation Initiation Factor 4E Family Member 3) is a Protein Coding gene. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E2.

UniProtKB/Swiss-Prot for EIF4E3 Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).

Gene Wiki entry for EIF4E3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4E3 Gene

Genomics for EIF4E3 Gene

Regulatory Elements for EIF4E3 Gene

Enhancers for EIF4E3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around EIF4E3 on UCSC Golden Path with GeneCards custom track

Promoters for EIF4E3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for EIF4E3 Gene

Chromosome:
3
Start:
71,675,416 bp from pter
End:
71,754,773 bp from pter
Size:
79,358 bases
Orientation:
Minus strand

Genomic View for EIF4E3 Gene

Genes around EIF4E3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4E3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4E3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E3 Gene

Proteins for EIF4E3 Gene

  • Protein details for EIF4E3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5X7-IF4E3_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E type 3
    Protein Accession:
    Q8N5X7
    Secondary Accessions:
    • B2R963
    • Q6NUT1

    Protein attributes for EIF4E3 Gene

    Size:
    224 amino acids
    Molecular mass:
    24441 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (By similarity).

    Alternative splice isoforms for EIF4E3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4E3 Gene

Post-translational modifications for EIF4E3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EIF4E3 Gene

Domains & Families for EIF4E3 Gene

Protein Domains for EIF4E3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF4E3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5X7

UniProtKB/Swiss-Prot:

IF4E3_HUMAN :
  • Belongs to the eukaryotic initiation factor 4E family.
Family:
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E3: view

No data available for Gene Families for EIF4E3 Gene

Function for EIF4E3 Gene

Molecular function for EIF4E3 Gene

UniProtKB/Swiss-Prot Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).

Gene Ontology (GO) - Molecular Function for EIF4E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
genes like me logo Genes that share ontologies with EIF4E3: view
genes like me logo Genes that share phenotypes with EIF4E3: view

Animal Models for EIF4E3 Gene

MGI Knock Outs for EIF4E3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF4E3 Gene

Localization for EIF4E3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4E3 Gene COMPARTMENTS Subcellular localization image for EIF4E3 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF4E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005845 mRNA cap binding complex ISS --
genes like me logo Genes that share ontologies with EIF4E3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4E3 Gene

Pathways & Interactions for EIF4E3 Gene

genes like me logo Genes that share pathways with EIF4E3: view

Gene Ontology (GO) - Biological Process for EIF4E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with EIF4E3: view

No data available for SIGNOR curated interactions for EIF4E3 Gene

Drugs & Compounds for EIF4E3 Gene

No Compound Related Data Available

Transcripts for EIF4E3 Gene

mRNA/cDNA for EIF4E3 Gene

(11) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF4E3 Gene

Eukaryotic translation initiation factor 4E family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - -
SP2:
SP3: -
SP4: - - -
SP5: - - - - -

Relevant External Links for EIF4E3 Gene

GeneLoc Exon Structure for
EIF4E3
ECgene alternative splicing isoforms for
EIF4E3

Expression for EIF4E3 Gene

mRNA expression in normal human tissues for EIF4E3 Gene

mRNA differential expression in normal tissues according to GTEx for EIF4E3 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for EIF4E3 Gene

This gene is overexpressed in Ovary (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF4E3 Gene



NURSA nuclear receptor signaling pathways regulating expression of EIF4E3 Gene:

EIF4E3

SOURCE GeneReport for Unigene cluster for EIF4E3 Gene:

Hs.581355
genes like me logo Genes that share expression patterns with EIF4E3: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for EIF4E3 Gene

Orthologs for EIF4E3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4E3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4E3 34
  • 95.16 (n)
  • 96.89 (a)
EIF4E3 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4E3 34
  • 95.35 (n)
  • 99.39 (a)
EIF4E3 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4e3 34
  • 89.12 (n)
  • 95.79 (a)
Eif4e3 16
Eif4e3 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4E3 34
  • 100 (n)
  • 100 (a)
EIF4E3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4e3 34
  • 87.91 (n)
  • 95.34 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF4E3 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4E3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4E3 34
  • 76.46 (n)
  • 82.47 (a)
EIF4E3 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4E3 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4e3 34
  • 75.36 (n)
  • 83.7 (a)
zebrafish
(Danio rerio)
Actinopterygii eif4e3 34
  • 74.69 (n)
  • 79.06 (a)
eif4e3 35
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ife-1 35
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToOne
Species where no ortholog for EIF4E3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E3 Gene

ENSEMBL:
Gene Tree for EIF4E3 (if available)
TreeFam:
Gene Tree for EIF4E3 (if available)

Paralogs for EIF4E3 Gene

Paralogs for EIF4E3 Gene

(3) SIMAP similar genes for EIF4E3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EIF4E3: view

Variants for EIF4E3 Gene

Sequence variations from dbSNP and Humsavar for EIF4E3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs877359 -- 71,730,337(+) AGGGT(A/G)CAGAT intron-variant, upstream-variant-2KB
rs935545 -- 71,729,771(-) AGAGA(C/G)AGGAA intron-variant, upstream-variant-2KB
rs935546 -- 71,715,379(-) GGAAA(A/G)GGCCT intron-variant
rs949642 -- 71,689,919(+) AGTAA(A/G)TCTGC intron-variant
rs949643 -- 71,689,969(+) ATGAT(A/G)GAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4E3 Gene

Variant ID Type Subtype PubMed ID
dgv8373n54 CNV gain 21841781
dgv8374n54 CNV gain 21841781
esv25003 CNV loss 19812545
esv28633 CNV loss 19812545
esv6263 CNV gain 19470904
nsv1144042 CNV deletion 24896259
nsv1144994 CNV deletion 24896259
nsv478618 CNV novel sequence insertion 20440878
nsv524847 CNV loss 19592680
nsv590600 CNV loss 21841781
nsv590601 CNV loss 21841781
nsv590606 CNV loss 21841781
nsv590610 CNV gain+loss 21841781
nsv590611 CNV loss 21841781
nsv834729 CNV loss 17160897
nsv999942 CNV gain 25217958

Variation tolerance for EIF4E3 Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4E3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4E3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4E3 Gene

Disorders for EIF4E3 Gene

Relevant External Links for EIF4E3

Genetic Association Database (GAD)
EIF4E3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4E3

No disorders were found for EIF4E3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4E3 Gene

Publications for EIF4E3 Gene

  1. Characterization of mammalian eIF4E-family members. (PMID: 15153109) Joshi B. … Jagus R. (Eur. J. Biochem. 2004) 2 3 65
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  3. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey M.L. … Hieter P. (Genetics 2015) 3 65
  4. MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. (PMID: 25403230) Landon A.L. … Gartenhaus R.B. (Nat Commun 2014) 3 65
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3 65

Products for EIF4E3 Gene

Sources for EIF4E3 Gene

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