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Aliases for EIF4E3 Gene

Aliases for EIF4E3 Gene

  • Eukaryotic Translation Initiation Factor 4E Family Member 3 2 3
  • EIF-4E3 3 4
  • EIF4E-3 3 4
  • Eukaryotic Translation Initiation Factor 4E Member 3 2
  • EIF-4E Type 3 4
  • EIF4E Type 3 4

External Ids for EIF4E3 Gene

Previous GeneCards Identifiers for EIF4E3 Gene

  • GC03U900551
  • GC03M071814

Summaries for EIF4E3 Gene

Entrez Gene Summary for EIF4E3 Gene

  • EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]

GeneCards Summary for EIF4E3 Gene

EIF4E3 (Eukaryotic Translation Initiation Factor 4E Family Member 3) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E1B.

UniProtKB/Swiss-Prot for EIF4E3 Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).

Gene Wiki entry for EIF4E3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4E3 Gene

Genomics for EIF4E3 Gene

Regulatory Elements for EIF4E3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF4E3 Gene

Chromosome:
3
Start:
71,675,416 bp from pter
End:
71,754,773 bp from pter
Size:
79,358 bases
Orientation:
Minus strand

Genomic View for EIF4E3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF4E3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E3 Gene

Proteins for EIF4E3 Gene

  • Protein details for EIF4E3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5X7-IF4E3_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E type 3
    Protein Accession:
    Q8N5X7
    Secondary Accessions:
    • B2R963
    • Q6NUT1

    Protein attributes for EIF4E3 Gene

    Size:
    224 amino acids
    Molecular mass:
    24441 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (By similarity).

    Alternative splice isoforms for EIF4E3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4E3 Gene

Proteomics data for EIF4E3 Gene at MOPED

Post-translational modifications for EIF4E3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for EIF4E3 Gene

Domains & Families for EIF4E3 Gene

Protein Domains for EIF4E3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF4E3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5X7

UniProtKB/Swiss-Prot:

IF4E3_HUMAN :
  • Belongs to the eukaryotic initiation factor 4E family.
Family:
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E3: view

No data available for Gene Families for EIF4E3 Gene

Function for EIF4E3 Gene

Molecular function for EIF4E3 Gene

UniProtKB/Swiss-Prot Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).

Gene Ontology (GO) - Molecular Function for EIF4E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003743 translation initiation factor activity IEA --
genes like me logo Genes that share ontologies with EIF4E3: view

Phenotypes for EIF4E3 Gene

MGI mutant phenotypes for EIF4E3:
inferred from 1 alleles
GenomeRNAi human phenotypes for EIF4E3:
genes like me logo Genes that share phenotypes with EIF4E3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF4E3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4E3 Gene

Localization for EIF4E3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4E3 Gene COMPARTMENTS Subcellular localization image for EIF4E3 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for EIF4E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005845 mRNA cap binding complex ISS --
genes like me logo Genes that share ontologies with EIF4E3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4E3 Gene

Pathways & Interactions for EIF4E3 Gene

genes like me logo Genes that share pathways with EIF4E3: view

Interacting Proteins for EIF4E3 Gene

Gene Ontology (GO) - Biological Process for EIF4E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with EIF4E3: view

No data available for SIGNOR curated interactions for EIF4E3 Gene

Drugs & Compounds for EIF4E3 Gene

No Compound Related Data Available

Transcripts for EIF4E3 Gene

mRNA/cDNA for EIF4E3 Gene

(6) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF4E3 Gene

Eukaryotic translation initiation factor 4E family member 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF4E3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - -
SP2:
SP3: -
SP4: - - -
SP5: - - - - -

Relevant External Links for EIF4E3 Gene

GeneLoc Exon Structure for
EIF4E3
ECgene alternative splicing isoforms for
EIF4E3

Expression for EIF4E3 Gene

mRNA expression in normal human tissues for EIF4E3 Gene

mRNA differential expression in normal tissues according to GTEx for EIF4E3 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for EIF4E3 Gene

This gene is overexpressed in Ovary (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4E3 Gene



SOURCE GeneReport for Unigene cluster for EIF4E3 Gene Hs.581355

genes like me logo Genes that share expression patterns with EIF4E3: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EIF4E3 Gene

Orthologs for EIF4E3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4E3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4E3 35
  • 95.16 (n)
  • 96.89 (a)
EIF4E3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4E3 35
  • 95.35 (n)
  • 99.39 (a)
EIF4E3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4e3 35
  • 89.12 (n)
  • 95.79 (a)
Eif4e3 16
Eif4e3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4E3 35
  • 100 (n)
  • 100 (a)
EIF4E3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4e3 35
  • 87.91 (n)
  • 95.34 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF4E3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4E3 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4E3 35
  • 76.46 (n)
  • 82.47 (a)
EIF4E3 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4E3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4e3 35
  • 75.36 (n)
  • 83.7 (a)
zebrafish
(Danio rerio)
Actinopterygii eif4e3 35
  • 74.69 (n)
  • 79.06 (a)
eif4e3 36
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ife-1 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for EIF4E3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E3 Gene

ENSEMBL:
Gene Tree for EIF4E3 (if available)
TreeFam:
Gene Tree for EIF4E3 (if available)

Paralogs for EIF4E3 Gene

Paralogs for EIF4E3 Gene

(3) SIMAP similar genes for EIF4E3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EIF4E3: view

Variants for EIF4E3 Gene

Sequence variations from dbSNP and Humsavar for EIF4E3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14826 -- 71,756,287(-) AACAA(C/T)CATCA upstream-variant-2KB
rs697253 -- 71,681,926(+) TACCA(C/T)GAATC utr-variant-3-prime
rs704296 -- 71,680,850(+) GAAGT(A/G)AACAA utr-variant-3-prime
rs704297 -- 71,681,714(+) AAGTT(C/T)GGCCA utr-variant-3-prime
rs704298 -- 71,682,197(+) TCAGA(C/T)TTCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF4E3 Gene

Variant ID Type Subtype PubMed ID
nsv834729 CNV Loss 17160897
esv6263 CNV Gain 19470904
esv25003 CNV Loss 19812545
nsv524847 CNV Loss 19592680
esv28633 CNV Loss 19812545

Variation tolerance for EIF4E3 Gene

Residual Variation Intolerance Score: 38.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4E3 Gene

HapMap Linkage Disequilibrium report
EIF4E3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4E3 Gene

Disorders for EIF4E3 Gene

Relevant External Links for EIF4E3

Genetic Association Database (GAD)
EIF4E3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4E3
genes like me logo Genes that share disorders with EIF4E3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4E3 Gene

Publications for EIF4E3 Gene

  1. Characterization of mammalian eIF4E-family members. (PMID: 15153109) Joshi B. … Jagus R. (Eur. J. Biochem. 2004) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition. (PMID: 23431134) Osborne M.J. … Borden K.L. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67
  4. eIF4E3, a new actor in mRNA metabolism and tumor suppression. (PMID: 23587918) Volpon L. … Borden K.L. (Cell Cycle 2013) 67
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 67

Products for EIF4E3 Gene

Sources for EIF4E3 Gene

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