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Aliases for EIF4E2 Gene

Aliases for EIF4E2 Gene

  • Eukaryotic Translation Initiation Factor 4E Family Member 2 2 3 5
  • Eukaryotic Translation Initiation Factor 4E-Like 3 2 3 4
  • Eukaryotic Translation Initiation Factor 4E Homologous Protein 3 4
  • MRNA Cap-Binding Protein Type 3 3 4
  • EIF4E-Like Protein 4E-LP 3 4
  • EIF-4E Type 2 3 4
  • EIF4EL3 3 4
  • EIF4E-Like Cap-Binding Protein 3
  • MRNA Cap-Binding Protein 4EHP 4
  • EIF4E Type 2 4
  • 4E-LP 3
  • 4EHP 3
  • IF4e 3

External Ids for EIF4E2 Gene

Previous HGNC Symbols for EIF4E2 Gene

  • EIF4EL3

Previous GeneCards Identifiers for EIF4E2 Gene

  • GC02P233240
  • GC02P233123
  • GC02P233414
  • GC02P225267

Summaries for EIF4E2 Gene

GeneCards Summary for EIF4E2 Gene

EIF4E2 (Eukaryotic Translation Initiation Factor 4E Family Member 2) is a Protein Coding gene. Among its related pathways are HIF-1 signaling pathway and Translation Insulin regulation of translation. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is EIF4E1B.

UniProtKB/Swiss-Prot for EIF4E2 Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

Gene Wiki entry for EIF4E2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4E2 Gene

Genomics for EIF4E2 Gene

Regulatory Elements for EIF4E2 Gene

Enhancers for EIF4E2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF4E2 on UCSC Golden Path with GeneCards custom track

Promoters for EIF4E2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF4E2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF4E2 Gene

Chromosome:
2
Start:
232,550,052 bp from pter
End:
232,583,645 bp from pter
Size:
33,594 bases
Orientation:
Plus strand

Genomic View for EIF4E2 Gene

Genes around EIF4E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E2 Gene

Proteins for EIF4E2 Gene

  • Protein details for EIF4E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60573-IF4E2_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E type 2
    Protein Accession:
    O60573
    Secondary Accessions:
    • B8ZZJ9
    • O75349

    Protein attributes for EIF4E2 Gene

    Size:
    245 amino acids
    Molecular mass:
    28362 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners (By similarity). EIF4E2 interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 but not with eIF4G.

    Three dimensional structures from OCA and Proteopedia for EIF4E2 Gene

    Alternative splice isoforms for EIF4E2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4E2 Gene

Proteomics data for EIF4E2 Gene at MOPED

Post-translational modifications for EIF4E2 Gene

  • ISGylation enhances its cap structure-binding activity and translation-inhibition activity.
  • Ubiquitinated by ARIH1, leading to its degradation by the proteasome.
  • Ubiquitination at Lys 239
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4E2 Gene

Domains & Families for EIF4E2 Gene

Protein Domains for EIF4E2 Gene

Suggested Antigen Peptide Sequences for EIF4E2 Gene

Graphical View of Domain Structure for InterPro Entry

O60573

UniProtKB/Swiss-Prot:

IF4E2_HUMAN :
  • Belongs to the eukaryotic initiation factor 4E family.
Family:
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E2: view

No data available for Gene Families for EIF4E2 Gene

Function for EIF4E2 Gene

Molecular function for EIF4E2 Gene

GENATLAS Biochemistry:
eukaryotic transcription factor 4E2,intron less,identified from chromosome 4-specific genome library
UniProtKB/Swiss-Prot Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

Gene Ontology (GO) - Molecular Function for EIF4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 9582349
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EIF4E2: view
genes like me logo Genes that share phenotypes with EIF4E2: view

Animal Models for EIF4E2 Gene

MGI Knock Outs for EIF4E2:

Animal Model Products

miRNA for EIF4E2 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF4E2 Gene

Localization for EIF4E2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4E2 Gene COMPARTMENTS Subcellular localization image for EIF4E2 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EIF4E2 Gene

Pathways & Interactions for EIF4E2 Gene

genes like me logo Genes that share pathways with EIF4E2: view

Gene Ontology (GO) - Biological Process for EIF4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with EIF4E2: view

No data available for SIGNOR curated interactions for EIF4E2 Gene

Drugs & Compounds for EIF4E2 Gene

(2) Drugs for EIF4E2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0
4EGI-1 Pharma Competitive eIF4E/eIF4G interaction inhibitor 0

(1) Additional Compounds for EIF4E2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for EIF4E2 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4E2: view

Transcripts for EIF4E2 Gene

Unigene Clusters for EIF4E2 Gene

Eukaryotic translation initiation factor 4E family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for EIF4E2 Gene

GeneLoc Exon Structure for
EIF4E2
ECgene alternative splicing isoforms for
EIF4E2

Expression for EIF4E2 Gene

mRNA expression in normal human tissues for EIF4E2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4E2 Gene



SOURCE GeneReport for Unigene cluster for EIF4E2 Gene Hs.292026

genes like me logo Genes that share expression patterns with EIF4E2: view

Protein tissue co-expression partners for EIF4E2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4E2 Gene

Orthologs for EIF4E2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4E2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4E2 35
  • 94.69 (n)
  • 99.18 (a)
EIF4E2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4E2 35
  • 96.05 (n)
  • 99.18 (a)
-- 36
  • 96 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
EIF4E2 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif4e2 35
  • 93.74 (n)
  • 98.37 (a)
Eif4e2 16
Eif4e2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4E2 35
  • 99.86 (n)
  • 100 (a)
EIF4E2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF4E2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4E2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4E2 35
  • 84.38 (n)
  • 96.4 (a)
EIF4E2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4E2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89871 35
  • 82.13 (n)
  • 95.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28437 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
eif4e2 35
  • 80 (n)
  • 92.27 (a)
eif4e2 36
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 4EHP 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ife-4 35
  • 60.08 (n)
  • 53.49 (a)
ife-4 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 36
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.894 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10582 35
  • 55.69 (n)
  • 49.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2600 36
  • 66 (a)
OneToOne
Species with no ortholog for EIF4E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E2 Gene

ENSEMBL:
Gene Tree for EIF4E2 (if available)
TreeFam:
Gene Tree for EIF4E2 (if available)

Paralogs for EIF4E2 Gene

Paralogs for EIF4E2 Gene

Pseudogenes.org Pseudogenes for EIF4E2 Gene

genes like me logo Genes that share paralogs with EIF4E2: view

Variants for EIF4E2 Gene

Sequence variations from dbSNP and Humsavar for EIF4E2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs719791 -- 232,554,336(+) TAGGG(C/T)GATAC intron-variant
rs719792 -- 232,554,256(+) GTTAA(C/T)TAGGC intron-variant
rs1550095 -- 232,563,738(-) AGTTA(C/G/T)TAAGC intron-variant
rs1550096 -- 232,563,675(-) TAAGC(A/G)TAAGT intron-variant
rs1550097 -- 232,563,565(-) GCTAG(A/G)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4E2 Gene

Variant ID Type Subtype PubMed ID
nsv821918 CNV Gain 20364138
nsv875977 CNV Loss 21882294
nsv875998 CNV Loss 21882294
nsv876000 CNV Gain 21882294
dgv4454n71 CNV Loss 21882294
nsv3212 CNV Loss 18451855
nsv876008 CNV Gain 21882294

Variation tolerance for EIF4E2 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4E2 Gene

HapMap Linkage Disequilibrium report
EIF4E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4E2 Gene

Disorders for EIF4E2 Gene

Relevant External Links for EIF4E2

Genetic Association Database (GAD)
EIF4E2
Human Genome Epidemiology (HuGE) Navigator
EIF4E2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4E2

No disorders were found for EIF4E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4E2 Gene

Publications for EIF4E2 Gene

  1. Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. (PMID: 9582349) Rom E. … Sonenberg N. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Weak binding affinity of human 4EHP for mRNA cap analogs. (PMID: 17369309) Zuberek J. … Darzynkiewicz E. (RNA 2007) 3 23
  3. Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms. (PMID: 17368478) Rosettani P. … Cameron A.D. (J. Mol. Biol. 2007) 3 23
  4. Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1. (PMID: 15094042) Tee A.R. … Blenis J. (FEBS Lett. 2004) 3 23
  5. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3

Products for EIF4E2 Gene

Sources for EIF4E2 Gene

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