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Aliases for EIF4E1B Gene

Aliases for EIF4E1B Gene

  • Eukaryotic Translation Initiation Factor 4E Family Member 1B 2 3 5

External Ids for EIF4E1B Gene

Previous GeneCards Identifiers for EIF4E1B Gene

  • GC05P176004
  • GC05P176057
  • GC05P170981

Summaries for EIF4E1B Gene

GeneCards Summary for EIF4E1B Gene

EIF4E1B (Eukaryotic Translation Initiation Factor 4E Family Member 1B) is a Protein Coding gene. Among its related pathways are Longevity regulating pathway and mTOR signaling pathway (KEGG). GO annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E.

UniProtKB/Swiss-Prot for EIF4E1B Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.

Additional gene information for EIF4E1B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4E1B Gene

Genomics for EIF4E1B Gene

Regulatory Elements for EIF4E1B Gene

Enhancers for EIF4E1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H176596 0.7 Ensembl ENCODE 11.9 -33.5 -33455 2.3 CTCF POLR2A RAD21 SNCB EIF4E1B TSPAN17 RN7SL684P CDHR2 FAF2 MIR1271 ARL10 KIAA1191 PIR54069
GH05H176824 0.9 FANTOM5 ENCODE 6.2 +192.6 192647 0.3 KLF1 ZNF687 USF2 KLF17 ELF1 ZNF217 SCRT2 WT1 NR2C2 ZBTB20 UNC5A HK3 SNCB EIF4E1B NSD1 GPRIN1 GC05M176812
GH05H176816 1.4 FANTOM5 Ensembl ENCODE 1.5 +186.8 186810 2.7 SCRT2 IKZF2 EGR2 SP3 ZNF398 ZNF341 IKZF1 ZBTB26 SP7 ZNF785 HK3 TSPAN17 UNC5A EIF4E1B GC05M176812
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF4E1B on UCSC Golden Path with GeneCards custom track

Genomic Locations for EIF4E1B Gene

Genomic Locations for EIF4E1B Gene
chr5:176,630,640-176,646,641
(GRCh38/hg38)
Size:
16,002 bases
Orientation:
Plus strand
chr5:176,057,683-176,073,642
(GRCh37/hg19)

Genomic View for EIF4E1B Gene

Genes around EIF4E1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4E1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4E1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E1B Gene

Proteins for EIF4E1B Gene

  • Protein details for EIF4E1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMX2-I4E1B_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E type 1B
    Protein Accession:
    A6NMX2

    Protein attributes for EIF4E1B Gene

    Size:
    242 amino acids
    Molecular mass:
    27596 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E AND EIF4G (By similarity).

neXtProt entry for EIF4E1B Gene

Post-translational modifications for EIF4E1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF4E1B Gene

No data available for DME Specific Peptides for EIF4E1B Gene

Domains & Families for EIF4E1B Gene

Gene Families for EIF4E1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF4E1B Gene

Suggested Antigen Peptide Sequences for EIF4E1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMX2

UniProtKB/Swiss-Prot:

I4E1B_HUMAN :
  • Belongs to the eukaryotic initiation factor 4E family.
Family:
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E1B: view

Function for EIF4E1B Gene

Molecular function for EIF4E1B Gene

UniProtKB/Swiss-Prot Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.

Gene Ontology (GO) - Molecular Function for EIF4E1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
genes like me logo Genes that share ontologies with EIF4E1B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EIF4E1B Gene

Localization for EIF4E1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4E1B gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for EIF4E1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005845 mRNA cap binding complex ISS --
genes like me logo Genes that share ontologies with EIF4E1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for EIF4E1B Gene

Pathways & Interactions for EIF4E1B Gene

genes like me logo Genes that share pathways with EIF4E1B: view

Gene Ontology (GO) - Biological Process for EIF4E1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with EIF4E1B: view

No data available for SIGNOR curated interactions for EIF4E1B Gene

Drugs & Compounds for EIF4E1B Gene

No Compound Related Data Available

Transcripts for EIF4E1B Gene

mRNA/cDNA for EIF4E1B Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF4E1B Gene

Eukaryotic translation initiation factor 4E family member 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E1B Gene

No ASD Table

Relevant External Links for EIF4E1B Gene

GeneLoc Exon Structure for
EIF4E1B
ECgene alternative splicing isoforms for
EIF4E1B

Expression for EIF4E1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4E1B Gene

mRNA differential expression in normal tissues according to GTEx for EIF4E1B Gene

This gene is overexpressed in Brain - Cortex (x10.2), Brain - Frontal Cortex (BA9) (x9.7), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Cerebellar Hemisphere (x4.7), and Brain - Cerebellum (x4.5).

Protein differential expression in normal tissues from HIPED for EIF4E1B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EIF4E1B Gene



Protein tissue co-expression partners for EIF4E1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4E1B Gene:

EIF4E1B

SOURCE GeneReport for Unigene cluster for EIF4E1B Gene:

Hs.448362
genes like me logo Genes that share expression patterns with EIF4E1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4E1B Gene

Orthologs for EIF4E1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4E1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4E1B 33 34
  • 98.76 (n)
cow
(Bos Taurus)
Mammalia EIF4E1B 33 34
  • 88.71 (n)
dog
(Canis familiaris)
Mammalia EIF4E1B 33 34
  • 82.7 (n)
rat
(Rattus norvegicus)
Mammalia Eif4e1b 33
  • 82.52 (n)
mouse
(Mus musculus)
Mammalia Eif4e1b 16 34 33
  • 80.79 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4E1B 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4E1B 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4E1B 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4e 33
  • 71.64 (n)
zebrafish
(Danio rerio)
Actinopterygii eif4e1b 33 34
  • 69.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF4E-6 34
  • 42 (a)
ManyToMany
eIF4E-4 34
  • 39 (a)
ManyToMany
eIF4E-5 34
  • 36 (a)
ManyToMany
eIF-4E 34
  • 34 (a)
ManyToMany
eIF4E-3 34
  • 32 (a)
ManyToMany
eIF4E-7 34
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ife-3 34
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 34
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29550 33
  • 50.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6167 34
  • 51 (a)
OneToMany
Species where no ortholog for EIF4E1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E1B Gene

ENSEMBL:
Gene Tree for EIF4E1B (if available)
TreeFam:
Gene Tree for EIF4E1B (if available)

Paralogs for EIF4E1B Gene

Paralogs for EIF4E1B Gene

(3) SIMAP similar genes for EIF4E1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EIF4E1B: view

Variants for EIF4E1B Gene

Sequence variations from dbSNP and Humsavar for EIF4E1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000148037 -- 176,635,496(+) AGAGT(C/G)TCGAG intron-variant
rs1000308166 -- 176,640,888(+) CTCCC(C/T)GACCC intron-variant
rs1000401913 -- 176,646,544(+) CTAGG(C/T)CTCAC upstream-variant-2KB, utr-variant-3-prime
rs1000524445 -- 176,643,786(+) CTGGG(A/C)TCCCT intron-variant
rs1000865120 -- 176,636,312(+) CCACC(G/T)GCGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4E1B Gene

Variant ID Type Subtype PubMed ID
nsv600346 CNV loss 21841781

Variation tolerance for EIF4E1B Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4E1B Gene

Human Gene Mutation Database (HGMD)
EIF4E1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4E1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4E1B Gene

Disorders for EIF4E1B Gene

Relevant External Links for EIF4E1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4E1B

No disorders were found for EIF4E1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4E1B Gene

Publications for EIF4E1B Gene

  1. Phylogenetic analysis of eIF4E-family members. (PMID: 16191198) Joshi B … Jagus R (BMC evolutionary biology 2005) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 60

Products for EIF4E1B Gene

Sources for EIF4E1B Gene

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