EIF4E Gene
protein-coding GIFtS: 73
GCID: GC04M099799
|
|
eukaryotic translation initiation factor 4E
(Previous symbols: EIF4EL1, EIF4F)
| |
Aliases
for EIF4E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 4E1 2 | | EIF-4F 25 KDa Subunit2 3 | | EIF4EL11 2 3 5 | | MRNA Cap-Binding Protein2 3 | | EIF4F1 2 3 | | CBP2 | | EIF4E11 2 | | Eukaryotic Translation Initiation Factor 4E-Like 12 | | EIF-4E1 | | EIF4E1 |
Export aliases for EIF4E gene to outside databasesPrevious GC identifers: GC04M100046 GC04M100193 GC04M100259 GC04M100158 GC04M095536 |
Summaries
for EIF4E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EIF4E:
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, whichrecognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids intranslation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is therate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been foundfor this gene. (provided by RefSeq, Jan 2012)
UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730Function: Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity).Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of proteinsynthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component ofthe CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In theCYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap
Gene Wiki entry for EIF4E
|
Genomic Views
for EIF4E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EIF4E gene promoter:
E2F-1 AP-1 ATF-2 STAT3 E2F-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF4E
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF4E |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q21-q25 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q21-q25EIF4E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M099799: view genomic region
(about GC identifiers)
Start:
|
99,792,835 bp from pter |
End:
|
99,851,788 bp from pter |
Size:
|
58,954 bases |
Orientation:
|
minus strand |
|
Proteins
for EIF4E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730 (See
protein sequence)Recommended Name: Eukaryotic translation initiation factor 4E Size: 217 amino acids; 25097 Da
Subunit: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmentalconditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with otherpartners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3)phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequentinitiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutuallyexclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composedof CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1 (By similarity). Interacts with Lassa virus Z protein. Bindsto MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner
Subcellular location: Cytoplasm, P-body
Mass spectrometry: Mass=24964.3; Method=Electrospray; Range=2-217; Source=PubMed:17036047;
Mass spectrometry: Mass=24960; Method=Electrospray; Range=2-217; Source=PubMed:17631896;
Caution: Was originally thought to be phosphorylated on Ser-53 (PubMed:3112145); this was later shown to be wrong(PubMed:7665584)
6/14 PDB 3D structures from  and Proteopedia  for EIF4E (see all 14):1IPB (3D)
1IPC (3D)
1WKW (3D)
2GPQ (3D)
2V8W (3D)
2V8X (3D)
Secondary accessions: B7Z6V1 D6RCQ6 Q96E95Alternative splicing: 3 isoforms: P06730-1 P06730-2 P06730-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for EIF4E: NX_P06730
Post-translational modifications:
Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P06730
EIF4E Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001124150.1 NP_001124151.1 NP_001959.1
ENSEMBL proteins: ENSP00000389624 ENSP00000280892 ENSP00000426602 ENSP00000421287 ENSP00000423977 ENSP00000425561 Reactome Protein details: P06730
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
EIF4E for ontologies About GeneDecksing
EIF4E Antibody Products:
Assay Products for EIF4E: |
Protein
Domains /
Families
for EIF4E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF4E for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P06730ProtoNet protein and cluster: P06730 1 Blocks protein family: IPB001040 Eukaryotic translation initiation factor 4E (eIF-4E)
UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730Similarity: Belongs to the eukaryotic initiation factor 4E family |
Function
for EIF4E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730Function: Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity).Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of proteinsynthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component ofthe CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In theCYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap Genatlas biochemistry entry for EIF4E:eukaryotic translation initiation factor 4E,amplified in head and neck squamous cell carcinomas
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4E (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4E (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for EIF4E | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4E |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4E |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EIF4E for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Eif4e):
EIF4E for phenotypes About GeneDecksing
|
Pathways & Interactions
for EIF4E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/40 super-pathways (see all 40) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | IRS-related events | | | 2 | Development_CNTF receptor signaling | | | 3 | Synthesis of PB1-F2 | | | 4 | Translation initiation complex formation | | | 5 | Translation_Translation regulation by Alpha-1 adrenergic receptors | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for EIF4E
5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF4E (see all 11)
1 
Cell Signaling Technology (CST) Pathway for EIF4E
4  GeneGo (Thomson Reuters) Pathways for EIF4E
5/9  BioSystems Pathways for EIF4E (see all 9)
5/42 
Reactome Pathways for EIF4E (see all 42)
3 
Kegg Pathways (Kegg details for EIF4E):
EIF4E for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF4E
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/369 Interacting proteins for EIF4E (P067301, 2, 3 ENSP000002808924) via UniProtKB, MINT, STRING, and/or I2D (see all 369)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000082 | G1/S transition of mitotic cell cycle |
IMP | 14673156 | | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
TAS | -- | | GO:0006406 | mRNA export from nucleus |
TAS | -- | | GO:0006412 | translation |
TAS | -- |
EIF4E for ontologies About GeneDecksing
|
Drugs & Compounds
for EIF4E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EIF4E for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for EIF4E |
 Browse Tocris compounds for EIF4E
4 DrugBank Compounds for EIF4E About this table
10/73 Novoseek chemical compound relationships for EIF4E gene (see all 73) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| m7gtp |
93.5 |
48 |
10772338 (3), 11959093 (3), 11879179 (3), 7666354 (2) (see all 24) |
| 7-methylguanosine |
87 |
19 |
15601771 (2), 18367715 (2), 16043507 (1), 19433856 (1) (see all 11) |
| rapamycin |
85.7 |
132 |
16103051 (4), 11847216 (4), 19560264 (4), 20177775 (3) (see all 66) |
| 7-methyl-gdp |
79.9 |
9 |
9478191 (2), 9200613 (2), 10349744 (1) |
| m(7)gpppg |
62.1 |
2 |
11156290 (1), 12356315 (1) |
| wortmannin |
57.6 |
10 |
15683719 (1), 9160663 (1), 11855825 (1), 15292274 (1) (see all 10) |
| ribavirin triphosphate |
57.6 |
2 |
16043507 (1), 16131589 (1) |
| 5-bromo-4-chloro-3-indolyl phosphate |
56.9 |
1 |
9605667 (1) |
| 7-methylguanine |
55.2 |
3 |
10349744 (1) |
| phosphatidylinositol |
51 |
12 |
11778052 (1), 17724079 (1), 11855825 (1), 12193593 (1) (see all 8) |
Search CenterWatch for drugs/clinical trials and news about EIF4E / IF4E
|
Transcripts
for EIF4E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EIF4E gene (3 alternative transcripts): NM_001130678.1 NM_001130679.1 NM_001968.3 Unigene Cluster for EIF4E: Eukaryotic translation initiation factor 4E Hs.249718 [show with all ESTs]Unigene Representative Sequence: NM_00113067911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450253(uc011cea.1 uc011ceb.1 uc003hue.2 uc011cec.1)
ENST00000280892 ENST00000515638 ENST00000511644 ENST00000504432 ENST00000505992
ENST00000505194 ENST00000507665 ENST00000505829 ENST00000504472 ENST00000418385
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4E (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4E (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): EIF4E (NM_001968) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF4E | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4E |
Additional cDNA sequence: AK295083.1 AK300982.1 BC012611.1 BC035166.1 BC043226.1 BC107715.1 M15353.1 23 DOTS entries: DT.91841951 DT.102831086 DT.40222616 DT.121245794 DT.100674184 DT.95364700 DT.100674186 DT.121245767 DT.405888 DT.121245764 DT.121245812 DT.310004 DT.92024643 DT.97854792 DT.100674178 DT.100835561 DT.121245754 DT.121245758 DT.120950180 DT.120950183 DT.121245779 DT.95193233 DT.99967230 24/485 AceView cDNA sequences (see all 485): CB151890 AW019946 CA442757 BQ022976 BU685005 CR623172 BQ948576 BQ048997 BU159748 BU182039 CA446421 BX101376 BE748389 AA736593 BU686657 AA804754 AU118135 BE550426 AL557603 BM470190 AA080948 BM755971 BF594389 CD369178
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EIF4E
|
Expression
for EIF4E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF4E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACATTGGT
About this image
See EIF4E Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF4E
SOURCE GeneReport for Unigene cluster: Hs.249718
SABiosciences Expression via Pathway-Focused PCR Arrays including EIF4E:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF4E
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF4E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF4E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF4E | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4E |
Orthologs
for EIF4E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF4E gene from 8/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
EIF4E1 |
eukaryotic translation initiation factor 4E |
85.71(n)
87.88(a) |
|
422703 XM_420655.3 XP_420655.3 |
lizard
(Anolis carolinensis) |
Reptilia |
EIF4E6 |
-- |
92(a) |
1 ↔ 1 |
GL343307.1(1422858-1438253) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.592 |
Xenopus laevis mRNA for translation initiation factor eIF-4E less |
81.8(n) |
|
D31837.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
eif4e-12 |
eukaryotic translation initiation factor eIF4E-1 |
79.63(n) |
|
79380 AF257519.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
eIF-4E3
eIF4E-71 |
protein biosynthesis translation initiation
factor less3
CG32859-PA1 |
52(a)
(best of 6)3
54.95(n)1
49.73(a)1 |
|
3 67B23
310591 NM_166870.11 NP_726718.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
B0348.6c3 |
-- |
51(a)
(best of 4) |
|
-- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
EIF4E1 |
translation initiation factor eIF-4E |
53.41(n)
44.44(a) |
|
827529 NM_117914.3 NP_193538.1 |
rice
(Oryza sativa) |
Liliopsida |
Os01g09704001 |
hypothetical protein |
51.21(n)
47.49(a) |
|
4323837 NM_001052060.1 NP_001045525.1 |
ENSEMBL Gene Tree for EIF4E (if available)
TreeFam Gene Tree for EIF4E (if available) |
Paralogs
for EIF4E gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EIF4E gene
- EIF4E1B2 EIF4E32 EIF4E22
4 SIMAP similar genes for EIF4E using alignment to 5 protein entries: IF4E_HUMAN (see all proteins):EIF4E1B EIF4E2 tmp_locus_9 EIF4E3
EIF4E for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for EIF4E
PGOHUM00000237104 PGOHUM00000247583 PGOHUM00000237887 PGOHUM00000250890 PGOHUM00000249577
|
Genomic Variants
for EIF4E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for EIF4E
2 CNVs: 63904 59157
Human Gene Mutation Database (HGMD): EIF4E
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF4E |
|
Disorders
/ Diseases
for EIF4E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EIF4E for disorders About GeneDecksing
OMIM gene information: 133440
OMIM disorders: --
20/68  diseases for EIF4E (see all 68): About MalaCardsdiffuse large b-cell lymphoma central nervous system lymphoma b-cell lymphomas laryngeal squamous cell carcinoma
mouth disease non-hodgkin lymphoma squamous cell carcinoma fragile x syndrome
skin squamous cell carcinoma hypopharynx cancer mantle cell lymphoma muscle hypertrophy
laryngitis acute promyelocytic leukemia myeloid leukemia hodgkin's lymphoma
pancreatic ductal adenocarcinoma cytomegalovirus infection tuberous sclerosis chronic lymphocytic leukemia
1 disease from the University of Copenhagen DISEASES database for EIF4E:Cancer 10/55 Novoseek disease relationships for EIF4E gene (see all 55) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| promyelocytic leukemia |
54.3 |
9 |
12167712 (1), 12438698 (1), 11959093 (1), 11963652 (1) (see all 8) |
| vocal cord polyp |
50.5 |
4 |
12838026 (1), 15510630 (1) |
| hnscc |
48.1 |
29 |
10077200 (4), 10383835 (3), 9247311 (3), 10561370 (2) (see all 9) |
| neoplastic transformation |
44.5 |
10 |
16024782 (2), 8246956 (1), 8529209 (1), 15894932 (1) (see all 6) |
| cancer recurrence |
44.5 |
38 |
18719964 (7), 16192819 (4), 11981220 (4), 19628077 (3) (see all 10) |
| cancer |
42.2 |
128 |
17091471 (4), 19367274 (4), 16633004 (4), 19628077 (3) (see all 61) |
| squamous cell cancer |
39.8 |
5 |
10910074 (1), 10561370 (1), 11745262 (1), 16280668 (1) (see all 5) |
| tumors |
37.1 |
181 |
10928042 (5), 16280668 (5), 19665145 (5), 16260273 (4) (see all 72) |
| laryngeal squamous cell carcinoma |
32.6 |
10 |
12838026 (3), 16124648 (2), 15510630 (2), 12889116 (1) |
| breast carcinoma |
24.8 |
29 |
18327707 (5), 9191527 (4), 9605667 (3), 15193258 (2) (see all 10) |
Human Genome Epidemiology (HuGE) Navigator: EIF4E (3 documents)
Tumor Gene Database (TGDB): EIF4E
Export disorders for EIF4E gene to outside databases
|
Publications
for EIF4E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EIF4E gene, integrated from 9 sources (see all 670):
(articles sorted by number of sources associating them with EIF4E) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. (PubMed id 16271312)1, 2, 9 Tomoo K.... Ishida T. (2005)
- Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PubMed id 9878069)1, 2, 9 Pyronnet S....Sonenberg N. (1999)
- Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives. (PubMed id 17631896)1, 2, 9 Brown C.J....Walkinshaw M.D. (2007)
- Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor- 4E. (PubMed id 8521827)1, 2, 9 Haghighat A.... Sonenberg N. (1995)
- Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. (PubMed id 11879179)1, 2, 9 Tomoo K.... Miura K. (2002)
- The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. (PubMed id 11154262)1, 2, 9 Scheper G.C.... Proud C.G. (2001)
- The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. (PubMed id 12897141)1, 2, 9 Scheper G.C....Proud C.G. (2003)
- Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. (PubMed id 1916814)1, 3, 9 Pelletier J....Housman D.E. (1991)
- Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2 Wichroski M.J....Rana T.M. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1, 2 Oh J.H....Kim N.S. (2005)
|
External Searches for EIF4E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing EIF4E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EIF4E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EIF4E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for EIF4E gene:
Search GeneIP for patents involving EIF4E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EIF4E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for EIF4E | | OriGene shRNA RFP for EIF4E | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF4E | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF4E | | | OriGene Protein Over-expression Lysate for EIF4E | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EIF4E | | OriGene 3'-UTR Clone for EIF4E | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4E | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4E | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EIF4E | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | Antibodies & Assays for EIF4E |
| | | | Search Tocris compounds for EIF4E |
| |  |  |  |  | | | | | | Recombinant Protein for EIF4E |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4E |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4E |
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