V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

EIF4E Gene

protein-coding GIFtS: 71

GC04M100046

eukaryotic translation initiation factor 4E
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: EIF4EL1, EIF4F)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CBP ^²
EIF4E1 ^¹, ²
EIF4EL1 ^², ³, ⁵
EIF4F ^², ³
MGC111573 ^²
eIF-4E ^³
eIF4E ^³

Descriptions
eIF-4F 25 kDa subunit ^², ³
eukaryotic translation initiation factor 4E ^²
eukaryotic translation initiation factor 4E-like 1 ^²
mRNA cap-binding protein ^², ³

External Ids
HGNC: 3287¹
Entrez Gene: 1977²
UniProtKB: P06730³
Ensembl: ENSG00000151247⁷

Search outside databases for aliases for EIF4E gene

Previous GC identifers: GC04M100193 GC04M100259 GC04M100158

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EIF4E:

All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap

structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular

processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear

export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the

cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a

multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the

eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic

protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM

601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G (MIM

600495) (Rychlik et al., 1987 [PubMed 3469651]).[supplied by OMIM]

UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730

Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in

the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of

the mRNAs secondary structures

Gene Wiki entry for EIF4E

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EIF4E gene

Entrez Gene cytogenetic band: 4q21-q25 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q21-q25

EIF4E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M100046: (about GC identifiers)

Start:	100,020,235 bp from pter
End:	100,070,139 bp from pter
Size:	49,905 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730 (See protein sequence)

Recommended Name: Eukaryotic translation initiation factor 4E

Size: 217 amino acids; 25097 Da

Subunit: eIF4F is a multi-subunit complex, the composition of which varies with external and

internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3.

EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the

import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with

EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3)

phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and

consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by

FKBPs. Interacts mutually exclusive with EIF4A1 and EIF4A2. Interacts with NGDN and PIWIL2 (By

similarity). Interacts with Lassa virus Z protein

Caution: Was originally thought to be phosphorylated on Ser-53 (PubMed:3112145); this was later

shown to be wrong (PubMed:7665584)

PDB structures from and Proteopedia :

1IPB (3D)

1IPC (3D)

1WKW (3D)

2GPQ (3D)

2V8W (3D)

2V8X (3D)

2V8Y (3D)

Secondary accessions: Q96E95

Post-translational modifications:

Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F

complex¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001124150.1 NP_001124151.1 NP_001959.1

ENSEMBL proteins:

ENSP00000378376 ENSP00000280892

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (eIF4E)
	Human Recombinant Proteins from Abnova (EIF4E)

OriGene Purified Recombinant Human Protein: EIF4E

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	7935836 8449919 12588972 15809305
GO:0016281	eukaryotic translation initiation factor 4F complex	TAS	3469651

About this table

Antibodies for EIF4E:

	Invitrogen Antibodies for EIF4E
	Millipore Mono- and Polyclonal Antibodies for the study of EIF4E
	Sigma-Aldrich Antibodies for EIF4E
	R&D Systems Antibodies for EIF4E
	Cell Signaling Technology (CST) Antibodies for EIF4E
	Antibodies from Abcam (eIF4E), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EIF4E)
	Novus Biologicals Antibodies for EIF4E

Assays for EIF4E:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Cell Signaling Technology (CST) Sandwich ELISA Kits for EIF4E
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06730

ProtoNet protein and cluster: P06730

1 Blocks protein family: IPB001040 Eukaryotic translation initiation factor 4E (eIF-4E)

UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730

Similarity: Belongs to the eukaryotic initiation factor 4E family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EIF4E)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001968

Applied Biosystems Silencer® siRNAs for EIF4E

Sigma-Aldrich siRNA for EIF4E

Sigma-Aldrich shRNA for EIF4E

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EIF4E
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130678
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130678
untagged cDNA clones in CMV expression vector (see all 3): NM_001130678

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001130679

UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730

Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in

the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of

the mRNAs secondary structures

Genatlas biochemistry entry for EIF4E:

eukaryotic translation initiation factor 4E,amplified in head and neck squamous cell carcinomas

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000339	RNA cap binding	TAS	3469651
GO:0003743	translation initiation factor activity	ISS	--
GO:0005515	protein binding	IPI	9878069 10856257 15153109 15247416 16739988 17353931 18805096

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for EIF4E (Your Favorite Gene powered by Ingenuity) (see all 6 )

Cardiac Hypertrophy Signaling
Insulin Receptor Signaling
PI3K/AKT Signaling
FLT3 Signaling in Hematopoietic Progenitor Cells
Axonal Guidance Signaling

GeneDecks EIF4E for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for EIF4E

5/199 Interacting proteins for EIF4E (P06730^{1, 2} ENSP00000280892³) via UniProtKB, MINT, and/or STRING (see all 199 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF4A1	P60842¹, ENSP00000369881³	EBI-73440, EBI-73449 STRING (score=.997)
EIF3A	Q14152², ENSP00000358140³	MINT-4791425 STRING (score=.995)
NCBP1	Q09161², ENSP00000364289³	MINT-4791425 STRING (score=.975)
EIF4A2	Q14240¹, ENSP00000326381³	EBI-73440, EBI-73473 STRING (score=.964)
EMX2	Q04743¹, ENSP00000358202³	EBI-73440, EBI-399831 STRING (score=.945)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006413	translational initiation	IEA	--
GO:0006417	regulation of translation	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EIF4E
10/39 Novoseek chemical compound relationships for EIF4E gene (see all 39 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
m7gtp	93.18	43	10772338 (3), 11959093 (3), 11879179 (3), 7666354 (2) (see all 22)
7-methylguanosine	84.46	17	15601771 (2), 18367715 (2), 16043507 (1), 10216941 (1) (see all 9)
7-methyl-gdp	80.60	9	9478191 (2), 9200613 (2), 10349744 (1)
m(7)gpppg	63.07	2	11156290 (1), 12356315 (1)
wortmannin	59.25	10	15683719 (1), 9160663 (1), 11855825 (1), 15292274 (1) (see all 10)
ribavirin triphosphate	58.94	2	16043507 (1), 16131589 (1)
5-bromo-4-chloro-3-indolyl phosphate	58.20	1	9605667 (1)
7-methylguanine	56.60	3	10349744 (1)
phosphatidylinositol	52.12	12	11778052 (1), 17724079 (1), 11855825 (1), 12193593 (1) (see all 8)
ornithine	44.46	4	10206976 (1), 10928042 (1), 8577715 (1), 19134194 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EIF4E)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001968

Sigma-Aldrich siRNA for EIF4E

Sigma-Aldrich shRNA for EIF4E

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130678 NM_001130679 NM_001968

REFSEQ mRNAs for EIF4E gene (3 alternative transcripts):

NM_001130678.1 NM_001130679.1 NM_001968.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001130678 NM_001130679 NM_001968

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130678
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130678
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001130678

Additional cDNA sequence:

AK295083.1 AK300982.1 BC012611.1 BC035166.1 BC043226.1 BC107715.1 CR600733.1 CR603932.1

CR606387.1 CR623172.1 M15353.1

24 DOTS entries:

DT.91841951 DT.102831086 DT.40222616 DT.121245794 DT.100674184 DT.95364700 DT.100674186 DT.121245767

DT.121245773 DT.405888 DT.121245764 DT.121245812 DT.310004 DT.92024643 DT.97854792 DT.100674178

DT.100835561 DT.121245754 DT.121245758 DT.95193233 DT.120950180 DT.120950183 DT.121245779 DT.99967230

24/485 AceView cDNA sequences (see all 485 ):

AV711283 BP377778 CB158948 BM754582 AL557603 BF447428 BQ022976 AI751010

BM788059 CA438559 CA441675 BM785456 BP377777 AA928352 CB151890 AA648270

BM803630 BF594389 BM476326 BM791786 BM470190 CA442757 BM755971 BU195126

highest scoring ESTs for EIF4E:

AA913840 AL698728 AU118135 AU129730 AU130285 AU133617 AU139526 BC012611 BC035166 BC043226

Unigene Cluster for EIF4E:

Eukaryotic translation initiation factor 4E

Hs.249718 [show with all ESTs]

Unigene Representative Sequence: NM_001130679

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10
SP1:					-						-
SP2:							-				-
SP3:
SP4:					-		-

About this scheme

ECgene alternative splicing isoforms for EIF4E

2 Ensembl transcripts including schematic representations:

ENST00000394918 ENST00000280892

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EIF4E expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EIF4E

¹ / ² / ³

12 probe-sets matching EIF4E gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56060_at²^{, 3}	U95-B	1	1.00	1.00	0.26	0.60	AA913840	0.80	1.00	0.91	1
37752_at²^{, 3}	U95-A	1	1.00	1.00	0.63	0.90	M15353	0.80	1.00	0.91	1
73201_at²^{, 3}	U95-E	1	1.00	1.00	0.52	1.51	AW019946	0.60	1.00	0.82	1
56158_r_at²^{, 3}	U95-C	1	1.00	1.00	0.49	0.29	AA040026	0.40	1.00	0.76	1
201435_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW268640	0.60	1.00	0.82	1
201437_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001968	0.60	1.00	0.82	1
237718_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA913840	0.80	1.00	0.91	1
201436_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI742789	0.40	1.00	0.76	1
201435_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201437_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
237718_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201436_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EIF4E for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAACATTGGT

SOURCE GeneReport for Unigene cluster: Hs.249718
Expression variation in blood from EXPOLDB for EIF4E

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EIF4E gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EIF4E¹	--	eukaryotic translation initiation factor 4E	97.08(n) 99.54(a)	487870 XM_544992.2 XP_544992.2
cow (Bos taurus)	EIF4E¹	--	eukaryotic translation initiation factor 4E	96.93(n) 99.08(a)	281751 NM_174310.3 NP_776735.2
rat (Rattus norvegicus)	Eif4e¹	--	eukaryotic translation initiation factor 4E	95.08(n) 98.16(a)	117045 NM_053974.2 NP_446426.1
mouse (Mus musculus)	Eif4e^{1, 5}	3 (25.00 cM)⁵	eukaryotic translation initiation factor 4E^{1, 5}	94.01(n)¹ 98.16(a)¹	13684¹ NM_007917.3¹ NP_031943.3¹ AK082867⁵ AK133004⁵ (see all 15)
chicken (Gallus gallus)	EIF4E¹	--	eukaryotic translation initiation factor 4E	90.23(n) 95.35(a)	422703 XM_420655.2 XP_420655.2

About this table Species with no ortholog for EIF4E

ENSEMBL Gene Tree for EIF4E

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EIF4E gene

EIF4E3² EIF4E1B² EIF4E2²

Pseudogenes

4 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/276 NCBI SNPs in EIF4E are shown (see all 276 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 83)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11723037^1,2	A,C,F,H	100069149(+)	`CATGAG/AGGGGA`	2	--	int¹ ut5¹ trp³		4	EU EA WA	410
	rs10433891^1,2	C,F,H	100019333(+)	`TAAACA/GCAGAA`	3	--	ut3¹		8	EU EA WA	810
	rs4699688^1,2	A,C,F	100019197(+)	`TACCAC/GTAACA`	3	--	ut3¹		3	NA	142
	rs10433890^1,2	C,F,H	100018945(+)	`TCAGCA/GTAATT`	3	--	ut3¹		10	EU EA WA	1018
	rs13107892^1,2	C,F,H	100071418(+)	`GTTGTT/CATTTT`	1	--	ng3¹		7	EU EA WA NA	542
	rs17028283^1,2	H	100070056(+)	`TTCTGT/CGCAAC`	2	--	ut5¹ ese³		7	NA EU EA WA	544
--	rs17008789^1,2	F	100020456(-)	`TGATTT/CCCTAA`	3	--	ut3¹		1	MN	184
	rs1237658^1,2	H	100070505(+)	`ACAACT/GGCAGC`	2	--	ut5¹		4	EU EA WA	418
	rs10004975^1,2	A,C,F,H	100035250(+)	`TATATG/CGCCAA`	1	--	int¹		3	EA WA	288
	rs12498533^1,2	A,C,F,H	100037856(+)	`CTGTAC/AAACAA`	1	--	int¹		11	EU EA WA NA	916

About this table

HapMap Linkage Disequilibrium images for EIF4E (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 133440

10/54 Novoseek disease relationships for EIF4E gene (see all 54 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
promyelocytic leukemia	54.24	8	12167712 (1), 12438698 (1), 11959093 (1), 11963652 (1) (see all 7)
vocal cord polyp	52.50	4	12838026 (1), 15510630 (1)
hnscc	48.48	29	10077200 (4), 10383835 (3), 9247311 (3), 10561370 (2) (see all 9)
neoplastic transformation	46.38	10	16024782 (2), 8246956 (1), 8529209 (1), 15894932 (1) (see all 6)
squamous cell cancer	42.00	5	10910074 (1), 10561370 (1), 11745262 (1), 16280668 (1) (see all 5)
cancer recurrence	41.05	30	18719964 (7), 16192819 (4), 11981220 (4), 9605667 (3) (see all 8)
cancer	39.45	115	17091471 (4), 19367274 (4), 16633004 (4), 16280668 (3) (see all 54)
laryngeal squamous cell carcinoma	35.30	10	12838026 (3), 16124648 (2), 15510630 (2), 12889116 (1)
tumors	34.52	163	10928042 (5), 16280668 (5), 16260273 (4), 10077200 (4) (see all 67)
breast carcinoma	27.05	29	18327707 (5), 9191527 (4), 9605667 (3), 15193258 (2) (see all 10)

About this table

Tumor Gene Database: EIF4E

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/543 PubMed articles for EIF4E gene (see all 543 ):

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PubMed id 9878069)^{1, 3, 4} Pyronnet S....Sonenberg N. (1999)
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor- 4E. (PubMed id 8521827)^{1, 3, 4} Haghighat A.... Sonenberg N. (1995)
Role of Ser-53 phosphorylation in the activity of human translation initiation factor eIF-4E in mammalian and yeast cells. (PubMed id 7590282)^{1, 3, 4} Zhang Y.... Schneider R.J. (1995)
Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. (PubMed id 11879179)^{1, 3, 4} Tomoo K.... Miura K. (2002)
The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. (PubMed id 11154262)^{1, 3, 4} Scheper G.C.... Proud C.G. (2001)
Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. (PubMed id 1916814)^{1, 2, 3} Pelletier J....Housman D.E. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII. (PubMed id 12975586)^{3, 4} Miura T.... Shimma N. (2003)
Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. (PubMed id 11408474)^{3, 4} Li W.... Proud C.G. (2001)
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. (PubMed id 10856257)^{3, 4} Dostie J.... Sonenberg N. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1977	HGNC: 3287	AceView: EIF4E	Ensembl:ENSG00000151247	euGenes: HUgn1977
ECgene: EIF4E	H-InvDB: EIF4E

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EIF4E	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for EIF4E
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EIF4E:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EIF4E-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EIF4E		Antibodies for EIF4E
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EIF4E		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EIF4E)
	Antibodies (EIF4E)
	Chimera RNAi (EIF4E)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for EIF4E

	Recombinant Proteins (eIF4E)
	Antibodies (eIF4E)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for EIF4E

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EIF4E

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
EIF4E Gene at Home site.
Version 2.41.1
server4.xennexinc.com

EIF4E Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for EIF4E

Summaries
for EIF4E

Genomic Location
for EIF4E

Proteins
for EIF4E

Protein Domains/
Families
for EIF4E

Gene Function
for EIF4E

Pathways & Interactions
for EIF4E

Drugs & Compounds
for EIF4E

Transcripts
for EIF4E

Expression
for EIF4E

Orthologs
for EIF4E

Paralogs
for EIF4E

SNPs/Variants
for EIF4E

Disorders & Mutations
for EIF4E

Medical News
for EIF4E

Publications
for EIF4E

Search for EIF4E

Genome Databases showing EIF4E

Other Databases showing EIF4E

Specialized Databases showing EIF4E

Licensable Technologies
for EIF4E

Services
for EIF4E

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EIF4E Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor EIF4E

Summariesfor EIF4E

Genomic Locationfor EIF4E

Proteinsfor EIF4E

Protein Domains/Familiesfor EIF4E

Gene Functionfor EIF4E

Pathways & Interactionsfor EIF4E

Drugs & Compoundsfor EIF4E

Transcriptsfor EIF4E

Expression for EIF4E

Orthologsfor EIF4E

Paralogsfor EIF4E

SNPs/Variantsfor EIF4E

Disorders & Mutationsfor EIF4E

Medical Newsfor EIF4E

Publicationsfor EIF4E

Search for EIF4E

Genome Databases showing EIF4E

Other Databases showing EIF4E

Specialized Databases showing EIF4E

Licensable Technologiesfor EIF4E

Servicesfor EIF4E

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EIF4E

Summaries
for EIF4E

Genomic Location
for EIF4E

Proteins
for EIF4E

Protein Domains/
Families
for EIF4E

Gene Function
for EIF4E

Pathways & Interactions
for EIF4E

Drugs & Compounds
for EIF4E

Transcripts
for EIF4E

Expression
for EIF4E

Orthologs
for EIF4E

Paralogs
for EIF4E

SNPs/Variants
for EIF4E

Disorders & Mutations
for EIF4E

Medical News
for EIF4E

Publications
for EIF4E

Licensable Technologies
for EIF4E

Services
for EIF4E