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Aliases for EIF4E Gene

Aliases for EIF4E Gene

  • Eukaryotic Translation Initiation Factor 4E 2 3
  • EIF4EL1 3 4 6
  • MRNA Cap-Binding Protein 3 4
  • EIF-4F 25 KDa Subunit 3 4
  • AUTS19 3 6
  • EIF-4E 3 4
  • EIF4F 3 4
  • Eukaryotic Translation Initiation Factor 4E-Like 1 3
  • EIF4E1 3
  • EIF4E 4
  • CBP 3

External Ids for EIF4E Gene

Previous HGNC Symbols for EIF4E Gene

  • EIF4EL1
  • EIF4F

Previous GeneCards Identifiers for EIF4E Gene

  • GC04M100046
  • GC04M100193
  • GC04M100259
  • GC04M100158
  • GC04M099799
  • GC04M095536

Summaries for EIF4E Gene

Entrez Gene Summary for EIF4E Gene

  • The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for EIF4E Gene

EIF4E (Eukaryotic Translation Initiation Factor 4E) is a Protein Coding gene. Diseases associated with EIF4E include autism 19 and hypopharynx cancer. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include translation initiation factor activity and eukaryotic initiation factor 4G binding. An important paralog of this gene is EIF4E1B.

UniProtKB/Swiss-Prot for EIF4E Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Gene Wiki entry for EIF4E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4E Gene

Genomics for EIF4E Gene

Regulatory Elements for EIF4E Gene

Genomic Location for EIF4E Gene

Start:
98,871,684 bp from pter
End:
98,930,637 bp from pter
Size:
58,954 bases
Orientation:
Minus strand

Genomic View for EIF4E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E Gene

Proteins for EIF4E Gene

  • Protein details for EIF4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06730-IF4E_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E
    Protein Accession:
    P06730
    Secondary Accessions:
    • B7Z6V1
    • D6RCQ6
    • Q96E95

    Protein attributes for EIF4E Gene

    Size:
    217 amino acids
    Molecular mass:
    25097 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:24207126, PubMed:25533957, PubMed:21661078). Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1. Interacts with CLOCK (By similarity). Interacts with Lassa virus Z protein. Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with LARP1.

    Three dimensional structures from OCA and Proteopedia for EIF4E Gene

    Alternative splice isoforms for EIF4E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4E Gene

Proteomics data for EIF4E Gene at MOPED

Post-translational modifications for EIF4E Gene

  • Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
  • Ubiquitination at Lys36 and Lys119
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF4E Gene

No data available for DME Specific Peptides for EIF4E Gene

Domains for EIF4E Gene

Graphical View of Domain Structure for InterPro Entry

P06730

UniProtKB/Swiss-Prot:

IF4E_HUMAN :
  • P06730
Family:
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E: view

No data available for Gene Families for EIF4E Gene

Function for EIF4E Gene

Molecular function for EIF4E Gene

GENATLAS Biochemistry: eukaryotic translation initiation factor 4E,amplified in head and neck squamous cell carcinomas
UniProtKB/Swiss-Prot Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Gene Ontology (GO) - Molecular Function for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 3469651
GO:0003723 RNA binding --
GO:0003743 translation initiation factor activity ISS --
GO:0005515 protein binding IPI 10772338
GO:0031370 eukaryotic initiation factor 4G binding IEA --
genes like me logo Genes that share ontologies with EIF4E: view

Phenotypes for EIF4E Gene

MGI mutant phenotypes for EIF4E:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with EIF4E: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF4E Gene

Localization for EIF4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF4E Gene

Cytoplasm, P-body. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4E Gene COMPARTMENTS Subcellular localization image for EIF4E gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 20616046
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005845 mRNA cap binding complex IDA 16271312
GO:0010494 cytoplasmic stress granule IDA 21883093
genes like me logo Genes that share ontologies with EIF4E: view

Pathways for EIF4E Gene

genes like me logo Genes that share pathways with EIF4E: view

Gene Ontology (GO) - Biological Process for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 14673156
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006412 translation TAS --
genes like me logo Genes that share ontologies with EIF4E: view

Compounds for EIF4E Gene

(73) Novoseek inferred chemical compound relationships for EIF4E Gene

Compound -log(P) Hits PubMed IDs
m7gtp 93.5 36
7-methylguanosine 87 13
rapamycin 85.7 84
7-methyl-gdp 79.9 5
m(7)gpppg 62.1 2
genes like me logo Genes that share compounds with EIF4E: view

Transcripts for EIF4E Gene

Unigene Clusters for EIF4E Gene

Eukaryotic translation initiation factor 4E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for EIF4E Gene

GeneLoc Exon Structure for
EIF4E
ECgene alternative splicing isoforms for
EIF4E

Expression for EIF4E Gene

mRNA expression in normal human tissues for EIF4E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EIF4E Gene

SOURCE GeneReport for Unigene cluster for EIF4E Gene Hs.249718

genes like me logo Genes that share expressions with EIF4E: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4E Gene

Orthologs for EIF4E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4E 35
  • 99.85 (n)
  • 100 (a)
EIF4E 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4E 35
  • 96.93 (n)
  • 99.08 (a)
EIF4E 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4E 35
  • 97.08 (n)
  • 99.54 (a)
EIF4E 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4e 35
  • 94.01 (n)
  • 98.16 (a)
Eif4e 16
Eif4e 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF4E 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4E 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4e 35
  • 95.08 (n)
  • 98.16 (a)
chicken
(Gallus gallus)
Aves EIF4E 35
  • 91.67 (n)
  • 97.4 (a)
EIF4E 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4E 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.59 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4e 35
  • 86.46 (n)
  • 91.88 (a)
Str.1980 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2851 35
zebrafish
(Danio rerio)
Actinopterygii eif4e-1 35
eif4ea 36
  • 84 (a)
OneToMany
eif4eb 35
  • 76.41 (n)
  • 89.23 (a)
eif4eb 36
  • 85 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007172 35
  • 54.85 (n)
  • 55.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF-4E 35
  • 56.34 (n)
  • 53.26 (a)
eIF-4E 36
  • 41 (a)
ManyToMany
eIF4E-3 36
  • 34 (a)
ManyToMany
eIF4E-4 36
  • 42 (a)
ManyToMany
eIF4E-5 36
  • 36 (a)
ManyToMany
eIF4E-6 36
  • 42 (a)
ManyToMany
eIF4E-7 36
  • 23 (a)
ManyToMany
CG8023 37
  • 41 (a)
CG1442 37
  • 48 (a)
CG10124 37
  • 45 (a)
EG:BACR42I17.1 37
  • 48 (a)
CG8277 37
  • 46 (a)
eIF-4E 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea ife-3 35
  • 54.01 (n)
  • 50.27 (a)
ife-3 36
  • 38 (a)
OneToMany
B0348.6c 37
  • 51 (a)
ife-2 37
  • 38 (a)
F53A2.6 37
  • 38 (a)
ife-5 37
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 36
  • 33 (a)
OneToMany
CDC33 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF4E 35
  • 53.56 (n)
  • 43.93 (a)
rice
(Oryza sativa)
Liliopsida Os01g0970400 35
  • 51.21 (n)
  • 47.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6167 36
  • 53 (a)
OneToMany
Species with no ortholog for EIF4E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E Gene

ENSEMBL:
Gene Tree for EIF4E (if available)
TreeFam:
Gene Tree for EIF4E (if available)

Paralogs for EIF4E Gene

Paralogs for EIF4E Gene

Selected SIMAP similar genes for EIF4E Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EIF4E: view

Variants for EIF4E Gene

Sequence variations from dbSNP and Humsavar for EIF4E Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs994636 -- 98,887,721(+) TTTTA(C/T)AAACA intron-variant
rs1052438 -- 98,929,688(-) GGGGA(C/T)GTGGG upstream-variant-2KB, utr-variant-5-prime
rs1052440 -- 98,929,685(-) GACGT(G/T)GGAGG upstream-variant-2KB, utr-variant-5-prime
rs1063526 -- 98,879,875(-) TCATA(A/T)ATATG utr-variant-3-prime
rs1237658 -- 98,930,331(+) ACAAC(G/T)GCAGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF4E Gene

Variant ID Type Subtype PubMed ID
nsv879654 CNV Loss 21882294
nsv879655 CNV Loss 21882294
nsv822666 CNV Loss 20364138
nsv821288 CNV Duplication 20802225
nsv819967 CNV Loss 19587683
esv27868 CNV Loss 19812545
esv1000667 CNV Gain 20482838
esv260038 OTHER Complex 20981092
esv997164 CNV Insertion 20482838

Relevant External Links for EIF4E Gene

HapMap Linkage Disequilibrium report
EIF4E
Human Gene Mutation Database (HGMD)
EIF4E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4E Gene

Disorders for EIF4E Gene

(1) OMIM Diseases for EIF4E Gene (133440)

UniProtKB/Swiss-Prot

IF4E_HUMAN
  • Autism 19 (AUTS19) [MIM:615091]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269 PubMed:19556253}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in families affected by autism. The variant results in increased promoter activity and is involved in disease pathogenesis through EIF4E deregulation (PubMed:19556253). {ECO:0000269 PubMed:19556253}.
  • Note=A chromosomal aberration involving EIF4E has been found in a patient with classic autism. Translocation t(45)(q23q31.3). The breakpoint on chromosome 4 is located 56 kb downstream of EIF4E (PubMed:19556253). {ECO:0000269 PubMed:19556253}.

(1) University of Copenhagen DISEASES for EIF4E Gene

(55) Novoseek inferred disease relationships for EIF4E Gene

Disease -log(P) Hits PubMed IDs
promyelocytic leukemia 54.3 8
vocal cord polyp 50.5 2
hnscc 48.1 20
neoplastic transformation 44.5 7
cancer recurrence 44.5 30

Relevant External Links for EIF4E

Genetic Association Database (GAD)
EIF4E
Human Genome Epidemiology (HuGE) Navigator
EIF4E
Tumor Gene Database (TGDB):
EIF4E
genes like me logo Genes that share disorders with EIF4E: view

Publications for EIF4E Gene

  1. Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. (PMID: 1916814) Pelletier J. … Housman D.E. (Genomics 1991) 2 3 23
  2. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor- 4E. (PMID: 8521827) Haghighat A. … Sonenberg N. (EMBO J. 1995) 3 4 23
  3. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PMID: 9878069) Pyronnet S. … Sonenberg N. (EMBO J. 1999) 3 4 23
  4. Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. (PMID: 11879179) Tomoo K. … Miura K. (Biochem. J. 2002) 3 4 23
  5. The N and C termini of the splice variants of the human mitogen- activated protein kinase-interacting kinase Mnk2 determine activity and localization. (PMID: 12897141) Scheper G.C. … Proud C.G. (Mol. Cell. Biol. 2003) 3 4 23

Products for EIF4E Gene

  • Addgene plasmids for EIF4E

Sources for EIF4E Gene

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