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EIF4E Gene

protein-coding   GIFtS: 72
GCID: GC04M099799

Eukaryotic Translation Initiation Factor 4E


(Previous symbols: EIF4EL1, EIF4F)
  See EIF4E-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 4E1 2     AUTS192 5
EIF4EL11 2 3 5     CBP2
EIF4F1 2 3     EIF4E12
eIF-4E2 3     Eukaryotic Translation Initiation Factor 4E-Like 12
EIF-4F 25 KDa Subunit2 3     eIF4E3
MRNA Cap-Binding Protein2 3     

External Ids:    HGNC: 32871   Entrez Gene: 19772   Ensembl: ENSG000001512477   OMIM: 1334405   UniProtKB: P067303   

Export aliases for EIF4E gene to outside databases

Previous GC identifers: GC04M100046 GC04M100193 GC04M100259 GC04M100158 GC04M095536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF4E Gene:
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which
recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in
translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is
the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for EIF4E Gene:
EIF4E (eukaryotic translation initiation factor 4E) is a protein-coding gene. Diseases associated with EIF4E include autism 19, and hypopharynx cancer. GO annotations related to this gene include eukaryotic initiation factor 4G binding and translation initiation factor activity. An important paralog of this gene is EIF4E3.

UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730
Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of
protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In
the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap

Gene Wiki entry for EIF4E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF4E gene promoter:
         E2F-1   AP-1   ATF-2   STAT3   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF4E promoter sequence
   Search Chromatin IP Primers for EIF4E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF4E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21-q25   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q21-q25

EIF4E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4E gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M099799:  view genomic region     (about GC identifiers)

Start:
99,792,835 bp from pter      End:
99,851,788 bp from pter
Size:
58,954 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 4E  
Size: 217 amino acids; 25097 Da
Subunit: eIF4F is a multi-subunit complex, the composition of which varies with external and internal
environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to
interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus.
Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin
stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing
EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation,
mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component
of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1 (By
similarity). Interacts with Lassa virus Z protein. Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and
AJUBA. Interacts with APOBEC3G in an RNA-dependent manner
Mass spectrometry: Mass=24964.3; Method=Electrospray; Range=2-217; Source=PubMed:17036047;
Mass spectrometry: Mass=24960; Method=Electrospray; Range=2-217; Source=PubMed:17631896;
Caution: Was originally thought to be phosphorylated on Ser-53 (PubMed:3112145); this was later shown to be wrong
(PubMed:7665584)
Selected PDB 3D structures from and Proteopedia for EIF4E (see all 15):
1IPB (3D)        1IPC (3D)        1WKW (3D)        2GPQ (3D)        2V8W (3D)        2V8X (3D)    
Secondary accessions: B7Z6V1 D6RCQ6 Q96E95
Alternative splicing: 3 isoforms:  P06730-1   P06730-2   P06730-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EIF4E: NX_P06730

Explore proteomics data for EIF4E at MOPED

Post-translational modifications: 

  • Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex1
  • Ubiquitination2 at Lys36, Lys119
  • Modification sites at PhosphoSitePlus

  • See EIF4E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124150.1  NP_001124151.1  NP_001959.1  

    ENSEMBL proteins: 
     ENSP00000389624   ENSP00000280892   ENSP00000426602   ENSP00000421287   ENSP00000423977  
     ENSP00000425561  
    Reactome Protein details: P06730

    EIF4E Human Recombinant Protein Products:

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    Novus Biologicals EIF4E Proteins
    Novus Biologicals EIF4E Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for EIF4E
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for EIF4E 

    EIF4E Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EIF4E
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for EIF4E 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001040 TIF_eIF_4E
     IPR019770 TIF_eIF_4E_CS
     IPR023398 TIF_eIF4e-like_dom

    Graphical View of Domain Structure for InterPro Entry P06730

    ProtoNet protein and cluster: P06730

    1 Blocks protein domain: IPB001040 Eukaryotic translation initiation factor 4E (eIF-4E)

    UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730
    Similarity: Belongs to the eukaryotic initiation factor 4E family


    Find genes that share domains with EIF4E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF4E_HUMAN, P06730
    Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of
    protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
    Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In
    the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap

         Genatlas biochemistry entry for EIF4E:
    eukaryotic translation initiation factor 4E,amplified in head and neck squamous cell carcinomas

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000339RNA cap binding TAS3469651
    GO:0003723RNA binding ----
    GO:0003743translation initiation factor activity ISS--
    GO:0005515protein binding IPI10772338
    GO:0031370eukaryotic initiation factor 4G binding IEA--
         
    Find genes that share ontologies with EIF4E           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Eif4e):
     cellular  tumorigenesis 

    Find genes that share phenotypes with EIF4E           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF4E
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    miRNA
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    miRTarBase miRNAs that target EIF4E:
    hsa-mir-141-3p (MIRT005479), hsa-mir-7-5p (MIRT025789), hsa-mir-505-5p (MIRT037944), hsa-mir-124-3p (MIRT022728), hsa-mir-145-5p (MIRT005878), hsa-mir-16-5p (MIRT001469), hsa-mir-1 (MIRT023809), hsa-mir-769-5p (MIRT039192)

    Block miRNA regulation of human, mouse, rat EIF4E using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF4E (see all 91):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-1258 hsa-miR-759 hsa-miR-550a* hsa-miR-637 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidEIF4E 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EIF4E

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): EIF4E (NM_001968)
    Sino Biological Human cDNA Clone for EIF4E
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF4E
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    Addgene plasmids for EIF4E 

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    eBioscience FlowRNA Probe Sets ( VA1-10846) for EIF4E 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IF4E_HUMAN, P06730: Cytoplasm, P-body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    cytoskeleton1
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005845mRNA cap binding complex IDA16271312
    GO:0010494cytoplasmic stress granule IDA--

    Find genes that share ontologies with EIF4E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF4E About   (see all 38)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    mTOR signaling pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Insulin signaling pathway0.32
    Translation Regulation activity of EIF4F0.44
    2Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.87
    IRS-related events0.94
    Signaling by Insulin receptor0.80
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PKB-mediated events0.41
    IRS-mediated signalling0.92
    mTOR signalling0.39
    3Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    Cap-dependent Translation Initiation0.89
    4Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Transport of the SLBP independent Mature mRNA0.91
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Mature mRNA Derived from an Intronless Transcript0.91
    5Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42


    Find genes that share SuperPaths with EIF4E           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for EIF4E
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF4E (see all 11)
        FLT3 Signaling
    IGF1R Signaling
    UVB-Induced MAPK Signaling
    eIF2 Pathway
    Interferon Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF4E
        Translational Control

    4 GeneGo (Thomson Reuters) Pathways for EIF4E
        Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation
    Translation Regulation of EIF4F activity
    Translation Translation regulation by Alpha-1 adrenergic receptors

    Selected BioSystems Pathways for EIF4E (see all 11)
        Insulin Signaling
    Translation Factors
    BDNF signaling pathway
    Interferon type I
    Alpha6-Beta4 Integrin Signaling Pathway


    Selected Reactome Pathways for EIF4E (see all 12)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    Release of eIF4E
    Transport of Mature mRNA Derived from an Intronless Transcript
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Transport of the SLBP independent Mature mRNA


    5 Kegg Pathways  (Kegg details for EIF4E):
        RNA transport
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    Insulin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EIF4E: 
              mTOR Signaling in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EIF4E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF4E (P067301, 2, 3 ENSP000002808924) via UniProtKB, MINT, STRING, and/or I2D (see all 472)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=2 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=2 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IMP14673156
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006406mRNA export from nucleus TAS--
    GO:0006412translation TAS--

    Find genes that share ontologies with EIF4E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for EIF4E (IF4E)

    4 DrugBank Compounds for EIF4E    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    7-Methyl-Guanosine-5'-Triphosphate-- --target--17139284 17016423 10592235
    7n-Methyl-8-Hydroguanosine-5'-Diphosphate-- --target--17139284 17016423 10592235
    7-Methyl-Gpppa-- --target--17139284 17016423
    2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for EIF4E gene (see all 73)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    m7gtp 93.5 48 10772338 (3), 11959093 (3), 11879179 (3), 7666354 (2) (see all 24)
    7-methylguanosine 87 19 15601771 (2), 18367715 (2), 16043507 (1), 19433856 (1) (see all 11)
    rapamycin 85.7 132 16103051 (4), 11847216 (4), 19560264 (4), 20177775 (3) (see all 66)
    7-methyl-gdp 79.9 9 9478191 (2), 9200613 (2), 10349744 (1)
    m(7)gpppg 62.1 2 11156290 (1), 12356315 (1)
    wortmannin 57.6 10 15683719 (1), 9160663 (1), 11855825 (1), 15292274 (1) (see all 10)
    ribavirin triphosphate 57.6 2 16043507 (1), 16131589 (1)
    5-bromo-4-chloro-3-indolyl phosphate 56.9 1 9605667 (1)
    7-methylguanine 55.2 3 10349744 (1)
    phosphatidylinositol 51 12 11778052 (1), 17724079 (1), 11855825 (1), 12193593 (1) (see all 8)



    Find genes that share compounds with EIF4E           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for EIF4E gene (3 alternative transcripts): 
    NM_001130678.1  NM_001130679.1  NM_001968.3  

    Unigene Cluster for EIF4E:

    Eukaryotic translation initiation factor 4E
    Hs.249718  [show with all ESTs]
    Unigene Representative Sequence: NM_001130679
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450253(uc011cea.1 uc011ceb.1 uc003hue.2 uc011cec.1)
    ENST00000280892 ENST00000515638 ENST00000511644 ENST00000504432 ENST00000505992
    ENST00000505194 ENST00000507665 ENST00000505829 ENST00000504472 ENST00000418385

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate EIF4E (see all 91):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-1258 hsa-miR-759 hsa-miR-550a* hsa-miR-637 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidEIF4E 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): EIF4E (NM_001968)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF4E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4E
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    Additional mRNA sequence: 

    AK295083.1 AK300982.1 BC012611.1 BC035166.1 BC043226.1 BC107715.1 M15353.1 

    23 DOTS entries:

    DT.91841951  DT.102831086  DT.40222616  DT.121245794  DT.100674184  DT.95364700  DT.100674186  DT.121245767 
    DT.405888  DT.121245764  DT.121245812  DT.310004  DT.92024643  DT.97854792  DT.100674178  DT.100835561 
    DT.121245754  DT.121245758  DT.120950180  DT.120950183  DT.121245779  DT.95193233  DT.99967230 

    Selected AceView cDNA sequences (see all 485):

    BI833459 AL557603 BU507883 BU195126 BQ022976 AW074034 BM754582 AA923475 
    BM476326 BU188278 BM788373 CA446802 BM803630 AA736593 BM791786 BQ949591 
    BU165917 BM788059 AA928352 AA369700 BM829425 BE550426 AV711283 F11703 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:              -                 -                                             
    SP2:                    -           -                                             
    SP3:                                                                              
    SP4:              -     -                                                         


    ECgene alternative splicing isoforms for EIF4E

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF4E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACATTGGT
    EIF4E Expression
    About this image


    EIF4E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    EIF4E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF4E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249718
        Pathway & Disease-focused RT2 Profiler PCR Arrays including EIF4E: 
              mTOR Signaling in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for EIF4E
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    QuantiFast Probe-based Assays in human, mouse, rat EIF4E
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF4E gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif4e1 , 5 eukaryotic translation initiation factor 4E1, 5 94.01(n)1
    98.16(a)1
      3 (64.30 cM)5
    136841  NM_007917.31  NP_031943.31 
     1385261915 
    chicken
    (Gallus gallus)
    Aves EIF4E1 eukaryotic translation initiation factor 4E 91.67(n)
    97.4(a)
      422703  XM_420655.4  XP_420655.4 
    lizard
    (Anolis carolinensis)
    Reptilia EIF4E6
    eukaryotic translation initiation factor 4E
    95(a)
    1 ↔ 1
    GL343307.1(1418634-1438253)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.592 Xenopus laevis mRNA for translation initiation factor more 81.8(n)    D31837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eif4e-12 eukaryotic translation initiation factor eIF4E-1 79.63(n)   79380  AF257519.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF-4E1 , 3 protein biosynthesis translation
    initiation factor3
    Eukaryotic initiation factor 4E1
    52(a)
    (best of 6)3
    56.34(n)1
    53.26(a)1
      3 67B23
    455251  NM_168338.21  NP_729485.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0348.6c3
    ife-31
    ife-31 51(a)
    (best of 4)3
    54.01(n)1
    50.27(a)1
      1785361  NM_070723.61  NP_503124.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC33(YOL139C)4 Cytoplasmic mRNA cap binding protein and translation more   --   15(61024-60383) 854026  NP_014502.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF4E1 EIF4E 53.56(n)
    43.93(a)
      827529  NM_117914.3  NP_193538.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g09704001 Os01g0970400 51.21(n)
    47.49(a)
      4323837  NM_001052060.1  NP_001045525.1 


    ENSEMBL Gene Tree for EIF4E (if available)
    TreeFam Gene Tree for EIF4E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF4E gene
    EIF4E32  EIF4E1B2  EIF4E22  
    4 SIMAP similar genes for EIF4E using alignment to 5 protein entries:     IF4E_HUMAN (see all proteins):
    EIF4E1B    EIF4E2    tmp_locus_9    EIF4E3

    Find genes that share paralogs with EIF4E           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for EIF4E
    PGOHUM00000237104 PGOHUM00000247583 PGOHUM00000237887 PGOHUM00000250890 PGOHUM00000249577


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF4E (see all 1017)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117259321,2
    C,F,A,H--99799310(+) TGACTG/AAACTA 3 -- ds500120Minor allele frequency- A:0.42NS EA NA WA CSA 935
    rs1479198981,2
    C--99799457(+) TATTCA/GCCCAT 3 -- ds50010--------
    rs709559501,2
    C--99799733(+) AAAAAA/-GAAAA 3 -- ut312Minor allele frequency- -:0.25NA 4
    rs344178011,2
    C--99799734(+) GTCTC-/AAAAAA 3 -- ut310--------
    rs1856806161,2
    --99799749(+) AAAAAA/GAAAGA 3 -- ut310--------
    rs1167167241,2
    C,F--99799831(+) ATAGCC/TTAATT 3 -- ut311Minor allele frequency- T:0.02NA 120
    rs104338901,2
    C,F,H--99799922(+) TCAGCA/GTAATT 3 -- ut3115Minor allele frequency- G:0.38EA NS NA WA CSA 968
    rs1417563671,2
    C--99800030(+) AAAATG/TTAGAA 3 -- ut310--------
    rs1437895681,2
    --99800065(+) CCTCCC/TTTGCA 3 -- ut310--------
    rs1885937771,2
    --99800092(+) TAAAAC/TTGGAC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for EIF4E (99792835 - 99851788 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for EIF4E:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821288CNV Duplication20802225
    esv997164CNV Insertion20482838
    nsv822666CNV Loss20364138
    esv27868CNV Loss19812545
    nsv879655CNV Loss21882294
    nsv879654CNV Loss21882294
    nsv819967CNV Loss19587683
    esv1000667CNV Gain20482838
    esv260038OTHER Complex20981092

    Human Gene Mutation Database (HGMD): EIF4E
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF4E
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF4E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 133440   
    OMIM disorders: 615091  
    UniProtKB/Swiss-Prot: IF4E_HUMAN, P06730
  • Autism 19 (AUTS19) [MIM:615091]: A complex multifactorial, pervasive developmental disorder characterized
    by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of
    interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals
    with autism also manifest moderate mental retardation. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in
    families affected by autism. The variant results in increased promoter activity and is involved in disease
    pathogenesis through EIF4E deregulation (PubMed:19556253)
  • Note=A chromosomal aberration involving EIF4E has been found in a patient with classic autism.
    Translocation t(45)(q23q31.3). The breakpoint on chromosome 4 is located 56 kb downstream of EIF4E
    (PubMed:19556253)

  • 6 diseases for EIF4E:    
    About MalaCards
    autism 19    hypopharynx cancer    laryngeal squamous cell carcinoma    mouth disease
    skin squamous cell carcinoma    laryngeal carcinoma

    1 disease from the University of Copenhagen DISEASES database for EIF4E:
    Cancer

    Find genes that share disorders with EIF4E           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EIF4E gene (see all 55)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 54.3 9 12167712 (1), 12438698 (1), 11959093 (1), 11963652 (1) (see all 8)
    vocal cord polyp 50.5 4 12838026 (1), 15510630 (1)
    hnscc 48.1 29 10077200 (4), 10383835 (3), 9247311 (3), 10561370 (2) (see all 9)
    neoplastic transformation 44.5 10 16024782 (2), 8246956 (1), 8529209 (1), 15894932 (1) (see all 6)
    cancer recurrence 44.5 38 18719964 (7), 16192819 (4), 11981220 (4), 19628077 (3) (see all 10)
    cancer 42.2 128 17091471 (4), 19367274 (4), 16633004 (4), 19628077 (3) (see all 61)
    squamous cell cancer 39.8 5 10910074 (1), 10561370 (1), 11745262 (1), 16280668 (1) (see all 5)
    tumors 37.1 181 10928042 (5), 16280668 (5), 19665145 (5), 16260273 (4) (see all 72)
    laryngeal squamous cell carcinoma 32.6 10 12838026 (3), 16124648 (2), 15510630 (2), 12889116 (1)
    breast carcinoma 24.8 29 18327707 (5), 9191527 (4), 9605667 (3), 15193258 (2) (see all 10)

    Genetic Association Database (GAD): EIF4E
    Human Genome Epidemiology (HuGE) Navigator: EIF4E (3 documents)
    Tumor Gene Database (TGDB): EIF4E

    Export disorders for EIF4E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF4E gene, integrated from 10 sources (see all 697):
    (articles sorted by number of sources associating them with EIF4E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. (PubMed id 16271312)1, 2, 9 Tomoo K.... Ishida T. (Biochim. Biophys. Acta 2005)
    2. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PubMed id 9878069)1, 2, 9 Pyronnet S....Sonenberg N. (EMBO J. 1999)
    3. Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives. (PubMed id 17631896)1, 2, 9 Brown C.J.... Walkinshaw M.D. (J. Mol. Biol. 2007)
    4. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor- 4E. (PubMed id 8521827)1, 2, 9 Haghighat A.... Sonenberg N. (EMBO J. 1995)
    5. Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. (PubMed id 11879179)1, 2, 9 Tomoo K.... Miura K. (Biochem. J. 2002)
    6. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. (PubMed id 11154262)1, 2, 9 Scheper G.C.... Proud C.G. (Mol. Cell. Biol. 2001)
    7. The N and C termini of the splice variants of the human mitogen- activated protein kinase-interacting kinase Mnk2 determine activity and localization. (PubMed id 12897141)1, 2, 9 Scheper G.C.... Proud C.G. (Mol. Cell. Biol. 2003)
    8. Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. (PubMed id 1916814)1, 3, 9 Pelletier J....Housman D.E. (Genomics 1991)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Deregulation of EIF4E: a novel mechanism for autism. (PubMed id 19556253)1, 2 Neves-Pereira M.... Miedzybrodzka Z. (J. Med. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1977 HGNC: 3287 AceView: EIF4E Ensembl:ENSG00000151247 euGenes: HUgn1977
    ECgene: EIF4E Kegg: 1977 H-InvDB: EIF4E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF4E Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF4E Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF4E gene:
    Search GeneIP for patents involving EIF4E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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