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Aliases for EIF4B Gene

Aliases for EIF4B Gene

  • Eukaryotic Translation Initiation Factor 4B 2 3 5
  • EIF-4B 3 4
  • PRO1843 3

External Ids for EIF4B Gene

Previous GeneCards Identifiers for EIF4B Gene

  • GC12P053558
  • GC12P053323
  • GC12P053116
  • GC12P051696
  • GC12P051686
  • GC12P053400
  • GC07P103668

Summaries for EIF4B Gene

GeneCards Summary for EIF4B Gene

EIF4B (Eukaryotic Translation Initiation Factor 4B) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is EIF4H.

UniProtKB/Swiss-Prot for EIF4B Gene

  • Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Gene Wiki entry for EIF4B Gene

Additional gene information for EIF4B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4B Gene

Genomics for EIF4B Gene

GeneHancer (GH) Regulatory Elements for EIF4B Gene

Promoters and enhancers for EIF4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I053003 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 592.2 +0.5 495 5.3 CLOCK MLX YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 EIF4B ZNF740 AAAS ATF7 CSAD PCBP2 SP1 MAP3K12 HOXC9 ENSG00000257808
GH12I053043 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.8 +43.5 43455 12 CLOCK MLX DMAP1 YY1 ZNF143 SP3 PPARGC1A SSRP1 ZNF610 GLIS1 TNS2 LOC283335 EIF4B MAP3K12 IGFBP6 C12orf10 SPRYD3
GH12I052894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 27.3 -103.2 -103230 16.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC12M052900 ZNF740 AAAS PCBP2 SP1 MAP3K12 ATF7 LOC100652999 EIF4B ENSG00000257808
GH12I052022 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.5 -980.9 -980924 5.1 HDGF ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 ZNF213 E2F8 NR4A1 HNRNPA3P10 EIF4B RNU6-574P ATG101 KRT80 GRASP ACVRL1 ENSG00000259884
GH12I053622 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 26 +619.0 618977 5 CLOCK MLX DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ATF7 ENSG00000267281 SP1 EIF4B ATP5MC2 PCBP2 AAAS ITGB7 HNRNPA1 ENSG00000258344
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF4B gene promoter:

Genomic Locations for EIF4B Gene

Genomic Locations for EIF4B Gene
chr12:53,006,158-53,042,209
(GRCh38/hg38)
Size:
36,052 bases
Orientation:
Plus strand
chr12:53,399,942-53,435,993
(GRCh37/hg19)

Genomic View for EIF4B Gene

Genes around EIF4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4B Gene

Proteins for EIF4B Gene

  • Protein details for EIF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23588-IF4B_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4B
    Protein Accession:
    P23588
    Secondary Accessions:
    • B4DS13
    • Q4G0E3
    • Q53HQ2
    • Q6GPH5
    • Q6IB46
    • Q8WYK5

    Protein attributes for EIF4B Gene

    Size:
    611 amino acids
    Molecular mass:
    69151 Da
    Quaternary structure:
    • Self-associates and interacts with EIF3 p170 subunit.

    Three dimensional structures from OCA and Proteopedia for EIF4B Gene

    Alternative splice isoforms for EIF4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4B Gene

Post-translational modifications for EIF4B Gene

  • Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.

No data available for DME Specific Peptides for EIF4B Gene

Domains & Families for EIF4B Gene

Gene Families for EIF4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF4B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EIF4B: view

No data available for UniProtKB/Swiss-Prot for EIF4B Gene

Function for EIF4B Gene

Molecular function for EIF4B Gene

UniProtKB/Swiss-Prot Function:
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Phenotypes From GWAS Catalog for EIF4B Gene

Gene Ontology (GO) - Molecular Function for EIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003743 translation initiation factor activity IBA,TAS --
GO:0004386 helicase activity TAS --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with EIF4B: view
genes like me logo Genes that share phenotypes with EIF4B: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4B Gene

Localization for EIF4B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4B gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005844 polysome IBA --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 2390971
genes like me logo Genes that share ontologies with EIF4B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4B Gene

Pathways & Interactions for EIF4B Gene

genes like me logo Genes that share pathways with EIF4B: view

SIGNOR curated interactions for EIF4B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0001731 formation of translation preinitiation complex IBA --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS,IEA --
GO:0006446 regulation of translational initiation TAS 2390971
genes like me logo Genes that share ontologies with EIF4B: view

Drugs & Compounds for EIF4B Gene

(4) Drugs for EIF4B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with EIF4B: view

Transcripts for EIF4B Gene

Unigene Clusters for EIF4B Gene

Eukaryotic translation initiation factor 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4B Gene

No ASD Table

Relevant External Links for EIF4B Gene

GeneLoc Exon Structure for
EIF4B
ECgene alternative splicing isoforms for
EIF4B

Expression for EIF4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF4B Gene

This gene is overexpressed in Nasal epithelium (8.6), Peripheral blood mononuclear cells (8.1), Lymph node (7.1), and Bone marrow stromal cell (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF4B Gene



Protein tissue co-expression partners for EIF4B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4B Gene:

EIF4B

SOURCE GeneReport for Unigene cluster for EIF4B Gene:

Hs.648394

Evidence on tissue expression from TISSUES for EIF4B Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.8)
  • Blood(4.1)
  • Intestine(4.1)
  • Skin(3.9)
  • Kidney(3.7)
  • Eye(3.6)
  • Pancreas(3.2)
  • Stomach(2.7)
  • Muscle(2.6)
  • Heart(2.5)
  • Spleen(2.5)
  • Bone(2)
genes like me logo Genes that share expression patterns with EIF4B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4B Gene

Orthologs for EIF4B Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4B 33
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia EIF4B 33 34
  • 92.8 (n)
cow
(Bos Taurus)
Mammalia EIF4B 33 34
  • 92.79 (n)
rat
(Rattus norvegicus)
Mammalia Eif4b 33
  • 90.89 (n)
mouse
(Mus musculus)
Mammalia Eif4b 33 16 34
  • 89.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 74 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves EIF4B 33 34
  • 75.28 (n)
lizard
(Anolis carolinensis)
Reptilia EIF4B 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4b 33
  • 68.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5042 33
zebrafish
(Danio rerio)
Actinopterygii eif4bb 33 34
  • 65.2 (n)
eif4ba 34
  • 65 (a)
OneToMany
wufb15c09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11972 33
fruit fly
(Drosophila melanogaster)
Insecta eIF-4B 34
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
CSA.9242 34
  • 30 (a)
OneToMany
Species where no ortholog for EIF4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4B Gene

ENSEMBL:
Gene Tree for EIF4B (if available)
TreeFam:
Gene Tree for EIF4B (if available)

Paralogs for EIF4B Gene

Variants for EIF4B Gene

Sequence variations from dbSNP and Humsavar for EIF4B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000161747 -- 53,029,514(+) TA/TATA intron_variant
rs1000168433 -- 53,037,264(+) A/G intron_variant
rs1000172573 -- 53,005,101(+) C/T upstream_transcript_variant
rs1000665301 -- 53,032,189(+) A/G intron_variant
rs1000773746 -- 53,038,679(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4B Gene

Variant ID Type Subtype PubMed ID
dgv188e201 CNV deletion 23290073
esv2668811 CNV deletion 23128226
esv2745902 CNV deletion 23290073
nsv1071031 CNV deletion 25765185
nsv517066 CNV loss 19592680
nsv973069 CNV duplication 23825009
nsv973070 CNV duplication 23825009
nsv976625 CNV duplication 23825009

Variation tolerance for EIF4B Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4B Gene

Disorders for EIF4B Gene

Additional Disease Information for EIF4B

No disorders were found for EIF4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4B Gene

Publications for EIF4B Gene

  1. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. (PMID: 16763566) Shahbazian D … Sonenberg N (The EMBO journal 2006) 3 4 22 58
  2. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. (PMID: 15071500) Raught B … Hershey JW (The EMBO journal 2004) 3 4 22 58
  3. A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3. (PMID: 8816444) Méthot N … Sonenberg N (Molecular and cellular biology 1996) 3 4 22 58
  4. Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. (PMID: 2390971) Milburn SC … Kaufman RJ (The EMBO journal 1990) 3 4 22 58
  5. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. (PMID: 17361185) Wilker EW … Yaffe MB (Nature 2007) 3 22 58

Products for EIF4B Gene

Sources for EIF4B Gene

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