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Aliases for EIF4B Gene

Aliases for EIF4B Gene

  • Eukaryotic Translation Initiation Factor 4B 2 3 5
  • EIF-4B 3 4
  • PRO1843 3

External Ids for EIF4B Gene

Previous GeneCards Identifiers for EIF4B Gene

  • GC12P053558
  • GC12P053323
  • GC12P053116
  • GC12P051696
  • GC12P051686
  • GC12P053400
  • GC07P103668

Summaries for EIF4B Gene

GeneCards Summary for EIF4B Gene

EIF4B (Eukaryotic Translation Initiation Factor 4B) is a Protein Coding gene. Diseases associated with EIF4B include Mouth Disease. Among its related pathways are RET signaling and MAPK Signaling: Mitogen Stimulation Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is EIF4H.

UniProtKB/Swiss-Prot for EIF4B Gene

  • Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Gene Wiki entry for EIF4B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4B Gene

Genomics for EIF4B Gene

Regulatory Elements for EIF4B Gene

Enhancers for EIF4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053043 2.1 FANTOM5 Ensembl ENCODE dbSUPER 26.8 +43.5 43455 12.0 MLX AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC PPARGC1A MEF2D LOC283335 EIF4B TNS2 HOXC6 HOXC4 HOXC9 HOXC8 IGFBP6 C12orf10 SPRYD3
GH12G053003 1.2 ENCODE 32.6 +0.5 495 5.3 MLX CREB3L1 YBX1 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 MEF2D EIF4B SP1 MAP3K12 LOC100652999 AAAS ZNF740 ENSG00000257808 HOXC9 ENSG00000257475
GH12G052999 1 ENCODE dbSUPER 27.3 -6.3 -6329 1.5 TBP FOXA2 SAP130 ETV1 ARID4B CEBPG EGR1 ZNF3 ZNF362 BHLHE40 EIF4B KRT8
GH12G053038 0.9 ENCODE dbSUPER 29 +32.8 32849 1.4 ZFP69B PAF1 ZNF121 CTCF ZNF654 SMC3 PRDM1 ZZZ3 RAD21 NR2F2 EIF4B LOC283335 IGFBP6 SOAT2 C12orf10 TNS2 ENSG00000257475
GH12G053042 0.9 ENCODE dbSUPER 28.6 +36.7 36677 0.6 ZSCAN5A SIN3A ZNF155 POLR2A PRDM10 KDM5B BCLAF1 SUPT5H EIF4B ZNF740 AAAS LOC100652999 TARBP2 TNS2 ENSG00000257475
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF4B on UCSC Golden Path with GeneCards custom track

Promoters for EIF4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052128 442 2401 MLX CREB3L1 DMAP1 YY1 SLC30A9 SP3 TBX21 MEF2D SSRP1 ZNF610

Genomic Location for EIF4B Gene

Chromosome:
12
Start:
53,006,158 bp from pter
End:
53,042,209 bp from pter
Size:
36,052 bases
Orientation:
Plus strand

Genomic View for EIF4B Gene

Genes around EIF4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4B Gene

Proteins for EIF4B Gene

  • Protein details for EIF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23588-IF4B_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4B
    Protein Accession:
    P23588
    Secondary Accessions:
    • B4DS13
    • Q4G0E3
    • Q53HQ2
    • Q6GPH5
    • Q6IB46
    • Q8WYK5

    Protein attributes for EIF4B Gene

    Size:
    611 amino acids
    Molecular mass:
    69151 Da
    Quaternary structure:
    • Self-associates and interacts with EIF3 p170 subunit.

    Three dimensional structures from OCA and Proteopedia for EIF4B Gene

    Alternative splice isoforms for EIF4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4B Gene

Post-translational modifications for EIF4B Gene

  • Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF4B (EIF4B)
  • Abcam antibodies for EIF4B

No data available for DME Specific Peptides for EIF4B Gene

Domains & Families for EIF4B Gene

Gene Families for EIF4B Gene

Protein Domains for EIF4B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EIF4B: view

No data available for UniProtKB/Swiss-Prot for EIF4B Gene

Function for EIF4B Gene

Molecular function for EIF4B Gene

UniProtKB/Swiss-Prot Function:
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Gene Ontology (GO) - Molecular Function for EIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0003743 translation initiation factor activity IBA,TAS --
GO:0004386 helicase activity TAS --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with EIF4B: view
genes like me logo Genes that share phenotypes with EIF4B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4B Gene

Localization for EIF4B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4B gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for EIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005844 polysome IBA --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 2390971
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with EIF4B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4B Gene

Pathways & Interactions for EIF4B Gene

genes like me logo Genes that share pathways with EIF4B: view

SIGNOR curated interactions for EIF4B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0001731 formation of translation preinitiation complex IBA --
GO:0002181 cytoplasmic translation IBA --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS,IEA --
genes like me logo Genes that share ontologies with EIF4B: view

Drugs & Compounds for EIF4B Gene

(4) Drugs for EIF4B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with EIF4B: view

Transcripts for EIF4B Gene

Unigene Clusters for EIF4B Gene

Eukaryotic translation initiation factor 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4B Gene

No ASD Table

Relevant External Links for EIF4B Gene

GeneLoc Exon Structure for
EIF4B
ECgene alternative splicing isoforms for
EIF4B

Expression for EIF4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF4B Gene

This gene is overexpressed in Nasal epithelium (8.6), Peripheral blood mononuclear cells (8.1), Lymph node (7.1), and Bone marrow stromal cell (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF4B Gene



Protein tissue co-expression partners for EIF4B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4B Gene:

EIF4B

SOURCE GeneReport for Unigene cluster for EIF4B Gene:

Hs.648394

Evidence on tissue expression from TISSUES for EIF4B Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.8)
  • Blood(4.1)
  • Intestine(4.1)
  • Skin(3.9)
  • Kidney(3.7)
  • Eye(3.6)
  • Pancreas(3.2)
  • Stomach(2.7)
  • Muscle(2.6)
  • Heart(2.5)
  • Spleen(2.5)
  • Bone(2)
genes like me logo Genes that share expression patterns with EIF4B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4B Gene

Orthologs for EIF4B Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4B 34
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia EIF4B 34 35
  • 92.8 (n)
cow
(Bos Taurus)
Mammalia EIF4B 34 35
  • 92.79 (n)
rat
(Rattus norvegicus)
Mammalia Eif4b 34
  • 90.89 (n)
mouse
(Mus musculus)
Mammalia Eif4b 34 16 35
  • 89.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves EIF4B 34 35
  • 75.28 (n)
lizard
(Anolis carolinensis)
Reptilia EIF4B 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4b 34
  • 68.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5042 34
zebrafish
(Danio rerio)
Actinopterygii eif4bb 34 35
  • 65.2 (n)
eif4ba 35
  • 65 (a)
OneToMany
wufb15c09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11972 34
fruit fly
(Drosophila melanogaster)
Insecta eIF-4B 35
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
CSA.9242 35
  • 30 (a)
OneToMany
Species where no ortholog for EIF4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4B Gene

ENSEMBL:
Gene Tree for EIF4B (if available)
TreeFam:
Gene Tree for EIF4B (if available)

Paralogs for EIF4B Gene

Variants for EIF4B Gene

Sequence variations from dbSNP and Humsavar for EIF4B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000161747 -- 53,029,513(+) GGGAC(-/TA)TACAG intron-variant
rs1000168433 -- 53,037,264(+) TGGAA(A/G)TACTT intron-variant
rs1000172573 -- 53,005,101(+) GTACC(C/T)GCAAG upstream-variant-2KB
rs1000665301 -- 53,032,189(+) TCTGT(A/G)ACAGC intron-variant
rs1000773746 -- 53,038,679(+) GTGTG(C/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4B Gene

Variant ID Type Subtype PubMed ID
dgv188e201 CNV deletion 23290073
esv2668811 CNV deletion 23128226
esv2745902 CNV deletion 23290073
nsv1071031 CNV deletion 25765185
nsv517066 CNV loss 19592680
nsv973069 CNV duplication 23825009
nsv973070 CNV duplication 23825009
nsv976625 CNV duplication 23825009

Variation tolerance for EIF4B Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4B Gene

Disorders for EIF4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF4B Gene - From: GeneCards

Disorder Aliases PubMed IDs
mouth disease
  • mouth disorders
- elite association - COSMIC cancer census association via MalaCards
Search EIF4B in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4B
genes like me logo Genes that share disorders with EIF4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4B Gene

Publications for EIF4B Gene

  1. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. (PMID: 16763566) Shahbazian D. … Sonenberg N. (EMBO J. 2006) 3 4 22 64
  2. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. (PMID: 15071500) Raught B. … Hershey J.W. (EMBO J. 2004) 3 4 22 64
  3. A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self- association and interaction with eIF3. (PMID: 8816444) Methot N. … Sonenberg N. (Mol. Cell. Biol. 1996) 3 4 22 64
  4. Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. (PMID: 2390971) Milburn S.C. … Kaufman R.J. (EMBO J. 1990) 3 4 22 64
  5. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. (PMID: 17361185) Wilker E.W. … Yaffe M.B. (Nature 2007) 3 22 64

Products for EIF4B Gene

Sources for EIF4B Gene

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