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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF4A3 Gene

protein-coding   GIFtS: 64
GCID: GC17M078109

Eukaryotic Translation Initiation Factor 4A3

(Previous names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 48, eukaryotic translation...)
(Previous symbol: DDX48)
  12 related diseases
at
MalaCards
 

Aliases
for EIF4A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Eukaryotic Translation Initiation Factor 4A31 2     NMP 2652 3
DDX481 2 3     Eukaryotic Translation Initiation Factor 4A, Isoform 31
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 481 2     NMP2652
Eukaryotic Initiation Factor 4A-Like NUK-342 3     NUK342
Nuclear Matrix Protein 2652 3     eIF4AIII2
ATP-Dependent RNA Helicase DDX482 3     Eukaryotic Initiation Factor 4A-III2
ATP-Dependent RNA Helicase EIF4A-32 3     Eukaryotic Translation Initiation Factor 4A2
DEAD Box Protein 482 3     EC 3.6.4.133
eIF-4A-III2 3     KIAA01113
eIF4A-III2 3     Eukaryotic Translation Initiation Factor 4A Isoform 33
HNMP 2652 3     EC 3.6.18

External Ids:    HGNC: 186831   Entrez Gene: 97752   Ensembl: ENSG000001415437   OMIM: 6085465   UniProtKB: P389193   

Export aliases for EIF4A3 gene to outside databases

Previous GC identifers: GC17M075724 GC17M073549


Summaries
for EIF4A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EIF4A3 Gene:
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes
involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial
splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this
family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The
protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino
acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box
protein family. (provided by RefSeq, Jul 2008)

GeneCards Summary for EIF4A3 Gene: 
EIF4A3 (eukaryotic translation initiation factor 4A3) is a protein-coding gene. Diseases associated with EIF4A3 include vaginal cancer, and vaginitis, and among its related super-pathways are Interferon Signaling and Metabolism of RNA. GO annotations related to this gene include ATP-dependent RNA helicase activity and poly(A) RNA binding. An important paralog of this gene is EIF4A1.

UniProtKB/Swiss-Prot: IF4A3_HUMAN, P38919
Function: ATP-dependent RNA helicase. Component of a splicing-dependent multiprotein exon junction complex (EJC)
deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and
several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either
during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to
spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction
in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing,
nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay
(NMD). Constitutes at least part of the platform anchoring other EJC proteins to spliced mRNAs. Its RNA-dependent
ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH/RBM8A
heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition
of ATPase activity by the MAGOH/RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in
translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in
sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for
single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed

Gene Wiki entry for EIF4A3 Gene


Genomic Views
for EIF4A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF4A3 gene promoter:
         Elk-1   p53   COMP1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EIF4A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF4A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF4A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

EIF4A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4A3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M078109:  view genomic region     (about GC identifiers)

Start:
 78,109,013 bp from pter      End:
 78,120,982 bp from pter
Size:
 11,970 bases      Orientation:
 minus strand

Proteins
for EIF4A3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: IF4A3_HUMAN, P38919 (See protein sequence)
Recommended Name: Eukaryotic initiation factor 4A-III  
Size: 411 amino acids; 46871 Da
Subunit: Part of the EJC core complex that contains CASC3, EIF4A3, MAGOH and RBM8A. Found in a mRNA
splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A,
RNPS1, SAP18 and ALYREF/THOC4. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. Identified in the
spliceosome C complex. May interact with NOM1. Interacts with POLDIP3
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to
the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as
the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By
similarity)
Sequence caution: Sequence=BAA04879.2; Type=Erroneous initiation;
6/7 PDB 3D structures from and Proteopedia for EIF4A3 (see all 7):
2HXY (3D)        2HYI (3D)        2J0Q (3D)        2J0S (3D)        2J0U (3D)        2XB2 (3D)    
Secondary accessions: Q15033 Q6IBQ2 Q96A18

Explore the universe of human proteins at neXtProt for EIF4A3: NX_P38919

Explore proteomics data for EIF4A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P38919

    • 4/36 DME Specific Peptides for EIF4A3 (P38919) (see all 36)
     LAPTREL  ELTLEGI  RVLISTD  GFKEQIY 

    EIF4A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF4A3 Protein Expression
    REFSEQ proteins: NP_055555.1  
    ENSEMBL proteins: 
     ENSP00000269349   ENSP00000460439  
    Reactome Protein details: P38919
    Human Recombinant Protein Products for EIF4A3: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for EIF4A3
    Cloud-Clone Corp. Proteins for EIF4A3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10523622
    GO:0005829cytosol TAS--
    GO:0016607nuclear speck IEA--
    GO:0035145exon-exon junction complex IDA16601204
    GO:0071013catalytic step 2 spliceosome IDA11991638

    EIF4A3 for ontologies           About GeneDecksing



    EIF4A3 Antibody Products: 
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    Assay Products for EIF4A3: 
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    Cloud-Clone Corp. ELISAs for EIF4A3 
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    Protein Domains /
    Families
    for EIF4A3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    DDX: DEAD-boxes

    5/6 InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry P38919

    ProtoNet protein and cluster: P38919

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: IF4A3_HUMAN, P38919
    Similarity: Belongs to the DEAD box helicase family. eIF4A subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    EIF4A3 for domains           About GeneDecksing


    Function
    for EIF4A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF4A3_HUMAN, P38919
    Function: ATP-dependent RNA helicase. Component of a splicing-dependent multiprotein exon junction complex (EJC)
    deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and
    several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either
    during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to
    spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction
    in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing,
    nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay
    (NMD). Constitutes at least part of the platform anchoring other EJC proteins to spliced mRNAs. Its RNA-dependent
    ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH/RBM8A
    heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition
    of ATPase activity by the MAGOH/RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in
    translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in
    sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for
    single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003729mRNA binding IDA--
    GO:0004004ATP-dependent RNA helicase activity IDA10523622
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI10523622
         
    EIF4A3 for ontologies           About GeneDecksing


    Phenotypes:
         13 GenomeRNAi human phenotypes for EIF4A3:
     Cell cycle / mitosis defect  Cell division defect  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/ 
     Decreased influenza A/WSN/33 r  Decreased viability  Increased G2M DNA content  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Nuclear 40S maturation defects  Nucleolar pre-40S maturation d  Synthetic lethal with Ras 
     Wnt reporter downregulated 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF4A3 
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Pathways & Interactions
    for EIF4A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF4A3 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    		Interferon Signaling0.61
    		Antiviral mechanism by IFN-stimulated genes0.42
    		Cytokine Signaling in Immune system0.61
    		ISG15 antiviral mechanism0.42
    2Metabolism of mRNA
    		Metabolism of mRNA0.92
    		Metabolism of RNA0.92
    3Viral mRNA Translation
    		Nonsense-Mediated Decay0.84
    		Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.84
    4Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay0.49
    		Deadenylation of mRNA0.47
    5Immune System
    		Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for EIF4A3
        Translational Control

    1 BioSystems Pathway for EIF4A3
        TNF-alpha/NF-kB Signaling Pathway


    5/12        Reactome Pathways for EIF4A3 (see all 12)
        Antiviral mechanism by IFN-stimulated genes
    Nonsense-Mediated Decay
    Cytokine Signaling in Immune system
    Deadenylation of mRNA
    Deadenylation-dependent mRNA decay


    3         Kegg Pathways  (Kegg details for EIF4A3):
        RNA transport
    mRNA surveillance pathway
    Spliceosome


    EIF4A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF4A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/997 Interacting proteins for EIF4A3 (P389191, 2, 3 ENSP000002693494) via UniProtKB, MINT, STRING, and/or I2D (see all 997)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096150P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000223367P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000226225P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000235650P622692, 3MINT-7945693 I2D: score=1 
    RPS18P622692, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006364rRNA processing IEA--

    EIF4A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EIF4A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EIF4A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF4A3 (IF4A3)

    1 Novoseek inferred chemical compound relationship for EIF4A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 30.2 5 16923391 (3), 16170325 (1), 19033377 (1)

    Search CenterWatch for drugs/clinical trials and news about EIF4A3 / IF4A3

    Transcripts
    for EIF4A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EIF4A3 gene: 
    NM_014740.3  

    Unigene Cluster for EIF4A3:

    Eukaryotic translation initiation factor 4A3
    Hs.389649  [show with all ESTs]
    Unigene Representative Sequence: NM_014740
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269349(uc010wuc.2 uc002jxs.3) ENST00000575978 ENST00000570625
    ENST00000576573 ENST00000575668 ENST00000570837 ENST00000576547 ENST00000575957

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    Additional mRNA sequence: 

    AK290608.1 BC003662.2 BC004386.1 BC011151.1 CR456750.1 D21853.1 X79538.1 

    14 DOTS entries:

    DT.218620  DT.100826334  DT.100030643  DT.100722721  DT.95261287  DT.100826322  DT.100826341  DT.95261297 
    DT.120891961  DT.120891978  DT.100826335  DT.100826338  DT.91774309  DT.95261300 

    24/521 AceView cDNA sequences (see all 521):

    AA338595 BQ226312 CR606403 BQ436667 BU620747 BE794069 BE797129 BI496267 
    CR602794 BG289705 AI084928 BE797384 BF314246 BM560888 CA418271 CB132040 
    BF095542 CR605620 AI754609 BM997621 BU683777 BE794160 BQ688246 BU687811 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                                                        -                                                           -                     
    SP2:                    -     -                             -                                                                                 
    SP3:              -     -     -                             -                                                                                 
    SP4:                                                        -                 -     -     -                                                   
    SP5:                          -                                                                                                               


    ECgene alternative splicing isoforms for EIF4A3

    Expression
    for EIF4A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF4A3 expression in normal human tissues (normalized intensities)      EIF4A3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAATAC
    EIF4A3 Expression
    About this image


    EIF4A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See EIF4A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF4A3

    SOURCE GeneReport for Unigene cluster: Hs.389649

    UniProtKB/Swiss-Prot: IF4A3_HUMAN, P38919
    Tissue specificity: Ubiquitously expressed

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    Orthologs
    for EIF4A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF4A3 gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Eif4a31 , 5 eukaryotic translation initiation factor 4A31, 5 86.94(n)1
    99.27(a)1    		   11 (83.35 cM)5
    1921701  NM_138669.11  NP_619610.11 
     1192883635 
    chicken
    (Gallus gallus)    		 Aves EIF4A31 eukaryotic translation initiation factor 4A3 83.71(n)
    99.26(a)    		   416704  NM_001030649.1  NP_001025820.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EIF4A36
    		 eukaryotic translation initiation factor 4A3
    		 93(a)
    		 1 ↔ 1
    		 1(254215650-254228709)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.7552 Xenopus laevis eukaryotic translation initiation factor more 82.56(n)    AF020432.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc561392 similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 83.22(n)   394053  BC045939.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta eIF4AIII1 CG7483-PA 74.2(n)
    87.94(a)    		   40987  NM_141531.2  NP_649788.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y65B4A.61 Protein Y65B4A.6 72.94(n)
    87.53(a)    		   190485  NM_058360.3  NP_490761.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes FAL1(YDR021W)4
    FAL11    		 Nucleolar protein required for maturation of 18S rRNA, more4
    Fal1p1    		 60.27(n)1
    62.4(a)1    		   4(486804-488003)4
    8515841, 4  NP_010304.31  NP_010304.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons EIF4A-III1 DEAD-box ATP-dependent RNA helicase 2 68.14(n)
    75.12(a)    		   821513  NM_112866.3  NP_188610.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.119912 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.79(n)    AK073640.1 


    ENSEMBL Gene Tree for EIF4A3 (if available)
    TreeFam Gene Tree for EIF4A3 (if available)

    Paralogs
    for EIF4A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF4A3 gene
    EIF4A12  EIF4A22  
    18/33 SIMAP similar genes for EIF4A3 using alignment to 2 protein entries:     IF4A3_HUMAN (see all proteins) (see all similar genes):
    EIF4A2    EIF4A1    DDX25    DDX56    DDX6    DKFZp566L241
    DDX19A    DDX19B    DDX19L    DDX39B    DKFZp762C1313    DDX39A
    DKFZp686C21137    DDX20    DDX47    E4-DBP    DDX54    DDX59

    EIF4A3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for EIF4A3
    PGOHUM00000234899 PGOHUM00000237979


    Genomic Variants
    for EIF4A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/390 SNPs in EIF4A3 are shown (see all 390)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs283726961,2
    		C--73561958(-) AGGGAATTC/-  
                AGGTC     		1 -- us2k13Minor allele frequency- -:0.20MN EA NA 1254
    rs1445110791,2
    		C--78108570(+) ATGAGC/TTGTGA 1 -- ds50010--------
    rs1863257951,2
    		--78108667(+) TGAAAG/TGGGCC 1 -- ds50010--------
    rs1401109731,2
    		--78108688(+) GCTCAC/TGCCTG 1 -- ds50010--------
    rs48898281,2
    		C,F,A,H--78108689(+) CTCACG/ACCTGT 1 -- ds50012Minor allele frequency- A:0.50NA WA 4
    rs1463799371,2
    		C--78108721(+) CGAGGC/TGGGTG 1 -- ds50010--------
    rs1397629041,2
    		--78108890(+) AGCTTA/GCGGTG 1 -- ds50010--------
    rs1911238891,2
    		--78108891(+) GCTTGC/TGGTGA 1 -- ds50010--------
    rs1145782531,2
    		C,F--78108892(+) CTTGCG/AGTGAG 1 -- ds50011Minor allele frequency- A:0.10WA 118
    rs1828591571,2
    		--78108950(+) TCTCAA/GAAAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for EIF4A3 (78109013 - 78120982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EIF4A3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833562CNV Loss17160897
    nsv469591CNV Loss16826518
    nsv833561CNV Loss17160897

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    Disorders / Diseases
    for EIF4A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 608546    OMIM disorders: --

    12 diseases for EIF4A3:    About MalaCards
    vaginal cancer    vaginitis    acute myeloid leukemia    kaposi's sarcoma
    myeloid leukemia    gastric cancer    pancreatic cancer    hypoxia
    sarcoma    pancreatitis    leukemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for EIF4A3:
    Vaginal cancer

    EIF4A3 for disorders           About GeneDecksing


    Export disorders for EIF4A3 gene to outside databases

    Publications
    for EIF4A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF4A3 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with EIF4A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. (PubMed id 10623621)1, 2, 3, 9 Holzmann K.... Sauermann G. (2000)
    2. eIF4A3 is a novel component of the exon junction complex. (PubMed id 14730019)1, 2, 3 Chan C.C....Dreyfuss G. (2004)
    3. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. (PubMed id 15034551)1, 2, 9 Shibuya T....Moore M.J. (2004)
    4. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. (PubMed id 16923391)1, 2, 9 Bono F.... Conti E. (2006)
    5. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PubMed id 16170325)1, 2, 9 Ballut L....Le Hir H. (2005)
    6. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. (PubMed id 18423201)1, 2 Ma X.M.... Blenis J. (2008)
    7. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. (PubMed id 16931718)1, 2 Andersen C.B....Andersen G.R. (2006)
    8. Exon-junction complex components specify distinct routes of nonsense- mediated mRNA decay with differential cofactor requirements. (PubMed id 16209946)1, 2 Gehring N.H.... Kulozik A.E. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)

    External Searches for EIF4A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EIF4A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9775 HGNC: 18683 AceView: DDX48 Ensembl:ENSG00000141543 euGenes: HUgn9775
    ECgene: EIF4A3 Kegg: 9775 H-InvDB: EIF4A3

    Other Databases showing EIF4A3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0111

    Specialized Databases showing EIF4A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF4A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EIF4A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EIF4A3 gene:
    Search GeneIP for patents involving EIF4A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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