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EIF4A3 Gene

protein-coding   GIFtS: 64
GCID: GC17M078109

Eukaryotic Translation Initiation Factor 4A3

(Previous names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 48, eukaryotic translation...)
(Previous symbol: DDX48)
  See related diseases
at
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Aliases
for EIF4A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 4A31 2     MUK342 5
DDX481 2 3 5     NMP2652 5
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 481 2     RCPS2 5
Eukaryotic Initiation Factor 4A-Like NUK-342 3     KIAA01113 5
Nuclear Matrix Protein 2652 3     Eukaryotic Translation Initiation Factor 4A, Isoform 31
ATP-Dependent RNA Helicase DDX482 3     NUK342
ATP-Dependent RNA Helicase EIF4A-32 3     eIF4AIII2
DEAD Box Protein 482 3     Eukaryotic Initiation Factor 4A-III2
eIF-4A-III2 3     Eukaryotic Translation Initiation Factor 4A2
eIF4A-III2 3     EC 3.6.4.133
HNMP 2652 3     Eukaryotic Translation Initiation Factor 4A Isoform 33
NMP 2652 3     EC 3.6.18

External Ids:    HGNC: 186831   Entrez Gene: 97752   Ensembl: ENSG000001415437   OMIM: 6085465   UniProtKB: P389193   

Export aliases for EIF4A3 gene to outside databases

Previous GC identifers: GC17M075724 GC17M073549


Summaries
for EIF4A3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF4A3 Gene:
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes
involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial
splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this
family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The
protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino
acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box
protein family. (provided by RefSeq, Jul 2008)

GeneCards Summary for EIF4A3 Gene:
EIF4A3 (eukaryotic translation initiation factor 4A3) is a protein-coding gene. Diseases associated with EIF4A3 include richieri costa pereira syndrome, and vaginal cancer. GO annotations related to this gene include mRNA binding and poly(A) binding. An important paralog of this gene is EIF4A1.

UniProtKB/Swiss-Prot: IF4A3_HUMAN, P38919
Function: ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex
(EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and
several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either
during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in
the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs
throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export,
subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent
ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A
heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition
of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in
translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in
sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for
single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing
modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic
isoforms such as Bcl-X(S); the function is different from the established EJC assembly

Gene Wiki entry for EIF4A3 Gene


Genomic Views
for EIF4A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF4A3 gene promoter:
         Elk-1   p53   COMP1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EIF4A3 promoter sequence
   Search Chromatin IP Primers for EIF4A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF4A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

EIF4A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4A3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M078109:  view genomic region     (about GC identifiers)

Start:
 78,109,013 bp from pter      End:
 78,120,982 bp from pter
Size:
 11,970 bases      Orientation:
 minus strand

Proteins
for EIF4A3 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IF4A3_HUMAN, P38919 (See protein sequence)
Recommended Name: Eukaryotic initiation factor 4A-III  
Size: 411 amino acids; 46871 Da
Subunit: Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3,
EIF4A3, MAGOH and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. Identified in the spliceosome
C complex. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA-independent
manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22
occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA
Sequence caution: Sequence=BAA04879.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for EIF4A3 (see all 8):
2HXY (3D)        2HYI (3D)        2J0Q (3D)        2J0S (3D)        2J0U (3D)        2XB2 (3D)    
Secondary accessions: Q15033 Q6IBQ2 Q96A18

Explore the universe of human proteins at neXtProt for EIF4A3: NX_P38919

Explore proteomics data for EIF4A3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys60, Lys152, Lys198, Lys289, Lys314, Lys374, Lys382
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for EIF4A3 (P38919) (see all 36)
     LAPTREL  ELTLEGI  RVLISTD  GFKEQIY 


    See EIF4A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055555.1  
    ENSEMBL proteins: 
     ENSP00000269349   ENSP00000460439  
    Reactome Protein details: P38919

    EIF4A3 Human Recombinant Protein Products:

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    EIF4A3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for EIF4A3

    EIF4A3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Domains /
    Families
    for EIF4A3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry P38919

    ProtoNet protein and cluster: P38919

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: IF4A3_HUMAN, P38919
    Similarity: Belongs to the DEAD box helicase family. eIF4A subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    EIF4A3 for domains           About GeneDecksing


    Function
    for EIF4A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF4A3_HUMAN, P38919
    Function: ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex
    (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and
    several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either
    during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in
    the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs
    throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export,
    subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent
    ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A
    heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition
    of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in
    translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in
    sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for
    single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing
    modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic
    isoforms such as Bcl-X(S); the function is different from the established EJC assembly
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Enzyme regulation: The ATPase activity is increased some 4-fold in the presence of RNA

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003729mRNA binding IDA--
    GO:0004004ATP-dependent RNA helicase activity IDA10523622
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI10523622
         
    EIF4A3 for ontologies           About GeneDecksing


    Phenotypes:
         13 GenomeRNAi human phenotypes for EIF4A3:
     Cell cycle / mitosis defect  Cell division defect  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/ 
     Decreased influenza A/WSN/33 r  Decreased viability  Increased G2M DNA content  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Nuclear 40S maturation defects  Nucleolar pre-40S maturation d  Synthetic lethal with Ras 
     Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF4A3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF4A3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF4A3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF4A3

    miRNA
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    hsa-mir-99b-5p (MIRT044207), hsa-mir-331-3p (MIRT043493), hsa-mir-18a-3p (MIRT040853), hsa-mir-324-3p (MIRT042843), hsa-mir-183-5p (MIRT047149), hsa-mir-877-3p (MIRT036955), hsa-mir-26b-5p (MIRT030151)

    Block miRNA regulation of human, mouse, rat EIF4A3 using miScript Target Protectors
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Localization
    for EIF4A3 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    IF4A3_HUMAN, P38919: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to
    the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as
    the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA10523622
    GO:0005829cytosol TAS--
    GO:0016607nuclear speck IEA--

    EIF4A3 for ontologies           About GeneDecksing


    Pathways & Interactions
    for EIF4A3 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF4A3 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    		Interferon Signaling0.59
    		ISG15 antiviral mechanism0.42
    		Cytokine Signaling in Immune system0.59
    		Antiviral mechanism by IFN-stimulated genes0.42
    2Influenza Viral RNA Transcription and Replication
    		Nonsense-Mediated Decay0.89
    		Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    3Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay0.48
    		Deadenylation of mRNA0.48
    4Gene Expression
    		Gene Expression0.40
    5Translational Control
    		Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for EIF4A3
        Translational Control

    1 BioSystems Pathway for EIF4A3
        TNF-alpha/NF-kB Signaling Pathway


    3 Reactome Pathways for EIF4A3
        Deadenylation of mRNA
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
    ISG15 antiviral mechanism


    3 Kegg Pathways  (Kegg details for EIF4A3):
        RNA transport
    mRNA surveillance pathway
    Spliceosome


    EIF4A3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF4A3
    Interactions:

        GeneGlobe Interaction Network for EIF4A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF4A3 (P389191, 2, 3 ENSP000002693494) via UniProtKB, MINT, STRING, and/or I2D (see all 1089)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096150P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000223367P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000226225P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000235650P622692, 3MINT-7945693 I2D: score=1 
    RPS18P622692, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006200ATP catabolic process IDA10523622

    EIF4A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EIF4A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF4A3 (IF4A3)

    1 Novoseek inferred chemical compound relationship for EIF4A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 30.2 5 16923391 (3), 16170325 (1), 19033377 (1)



    EIF4A3 for compounds           About GeneDecksing



    Transcripts
    for EIF4A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for EIF4A3 gene: 
    NM_014740.3  

    Unigene Cluster for EIF4A3:

    Eukaryotic translation initiation factor 4A3
    Hs.389649  [show with all ESTs]
    Unigene Representative Sequence: NM_014740
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269349(uc010wuc.2 uc002jxs.3) ENST00000575978 ENST00000570625
    ENST00000576573 ENST00000575668 ENST00000570837 ENST00000576547 ENST00000575957

    miRNA
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    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat EIF4A3
      QuantiFast Probe-based Assays in human, mouse, rat EIF4A3

    Additional mRNA sequence: 

    AK290608.1 BC003662.2 BC004386.1 BC011151.1 CR456750.1 D21853.1 X79538.1 

    14 DOTS entries:

    DT.218620  DT.100826334  DT.100030643  DT.100722721  DT.95261287  DT.100826322  DT.100826341  DT.95261297 
    DT.120891961  DT.120891978  DT.100826335  DT.100826338  DT.91774309  DT.95261300 

    Selected AceView cDNA sequences (see all 521):

    BM784864 BM450876 BQ018784 BQ430678 BF795216 BM997621 BQ961727 BU171694 
    CR605620 BQ648921 BM743519 CD366832 CA429602 BE797384 BQ637916 BE561444 
    BI836908 CR594986 AW675826 BI496267 AA478031 BG470881 BM785555 CB158308 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                                                        -                                                           -                     
    SP2:                    -     -                             -                                                                                 
    SP3:              -     -     -                             -                                                                                 
    SP4:                                                        -                 -     -     -                                                   
    SP5:                          -                                                                                                               


    ECgene alternative splicing isoforms for EIF4A3

    Expression
    for EIF4A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF4A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAATAC
    EIF4A3 Expression
    About this image


    EIF4A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    EIF4A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    EIF4A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389649

    UniProtKB/Swiss-Prot: IF4A3_HUMAN, P38919
    Tissue specificity: Ubiquitously expressed

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    Orthologs
    for EIF4A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF4A3 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Eif4a31 , 5 eukaryotic translation initiation factor 4A31, 5 86.94(n)1
    99.27(a)1    		   11 (83.35 cM)5
    1921701  NM_138669.11  NP_619610.11 
     1192883635 
    chicken
    (Gallus gallus)    		 Aves EIF4A31 eukaryotic translation initiation factor 4A3 83.09(n)
    97.56(a)    		   416704  NM_001030649.1  NP_001025820.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EIF4A36
    		 eukaryotic translation initiation factor 4A3
    		 93(a)
    		 1 ↔ 1
    		 1(254215650-254228709)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.7552 Xenopus laevis eukaryotic translation initiation factor more 82.56(n)    AF020432.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc561392 similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 83.22(n)   394053  BC045939.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta eIF4AIII1 eIF4AIII 74.2(n)
    87.94(a)    		   40987  NM_141531.2  NP_649788.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y65B4A.61 Y65B4A.6 72.94(n)
    87.53(a)    		   190485  NM_058360.4  NP_490761.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes FAL1(YDR021W)4
    FAL11    		 Nucleolar protein required for maturation of 18S rRNA, more4
    FAL11    		 60.27(n)1
    62.4(a)1    		   4(486804-488003)4
    8515841, 4  NP_010304.31  NP_010304.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons EIF4A-III1 EIF4A-III 68.56(n)
    75.56(a)    		   821513  NM_112866.3  NP_188610.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.119912 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.79(n)    AK073640.1 


    ENSEMBL Gene Tree for EIF4A3 (if available)
    TreeFam Gene Tree for EIF4A3 (if available)

    Paralogs
    for EIF4A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF4A3 gene
    EIF4A12  EIF4A22  
    Selected SIMAP similar genes for EIF4A3 using alignment to 2 protein entries:     IF4A3_HUMAN (see all proteins) (see all similar genes):
    EIF4A2    EIF4A1    DDX25    DDX56    DDX6    DKFZp566L241
    DDX19A    DDX19B    DDX19L    DDX39B    DKFZp762C1313    DDX39A
    DKFZp686C21137    DDX20    DDX47    E4-DBP    DDX54    DDX59

    EIF4A3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for EIF4A3
    PGOHUM00000234899 PGOHUM00000237979


    Genomic Variants
    for EIF4A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF4A3 (see all 390)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs283726961,2
    		C--73561958(-) AGGGAATTC/-  
                AGGTC     		1 -- us2k13Minor allele frequency- -:0.20MN EA NA 1254
    rs1445110791,2
    		C--78108570(+) ATGAGC/TTGTGA 1 -- ds50010--------
    rs1863257951,2
    		--78108667(+) TGAAAG/TGGGCC 1 -- ds50010--------
    rs1401109731,2
    		--78108688(+) GCTCAC/TGCCTG 1 -- ds50010--------
    rs48898281,2
    		C,F,A,H--78108689(+) CTCACG/ACCTGT 1 -- ds50012Minor allele frequency- A:0.50NA WA 4
    rs1463799371,2
    		C--78108721(+) CGAGGC/TGGGTG 1 -- ds50010--------
    rs1397629041,2
    		--78108890(+) AGCTTA/GCGGTG 1 -- ds50010--------
    rs1911238891,2
    		--78108891(+) GCTTGC/TGGTGA 1 -- ds50010--------
    rs1145782531,2
    		C,F--78108892(+) CTTGCG/AGTGAG 1 -- ds50011Minor allele frequency- A:0.10WA 118
    rs1828591571,2
    		--78108950(+) TCTCAA/GAAAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for EIF4A3 (78109013 - 78120982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EIF4A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833562CNV Loss17160897
    nsv469591CNV Loss16826518
    nsv833561CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for EIF4A3

    Disorders / Diseases
    for EIF4A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608546   
    OMIM disorders: 268305  
    19 diseases for EIF4A3:    
    About MalaCards
    richieri costa pereira syndrome    vaginal cancer    vaginitis    kaposi's sarcoma
    acute myeloid leukemia    sarcoma    myeloid leukemia    tonsillitis
    hypoxia    pancreatic cancer    pancreatitis    neuroblastoma
    leukemia    thyroiditis    malaria    cerebritis
    prostatitis    neuronitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for EIF4A3:
    Vaginal cancer

    EIF4A3 for disorders           About GeneDecksing


    Export disorders for EIF4A3 gene to outside databases

    Publications
    for EIF4A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF4A3 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with EIF4A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. (PubMed id 10623621)1, 2, 3, 9 Holzmann K.... Sauermann G. (Biochem. Biophys. Res. Commun. 2000)
    2. eIF4A3 is a novel component of the exon junction complex. (PubMed id 14730019)1, 2, 3 Chan C.C....Dreyfuss G. (RNA 2004)
    3. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. (PubMed id 15034551)1, 2, 9 Shibuya T.... Moore M.J. (Nat. Struct. Mol. Biol. 2004)
    4. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. (PubMed id 16923391)1, 2, 9 Bono F.... Conti E. (Cell 2006)
    5. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PubMed id 16170325)1, 2, 9 Ballut L....Le Hir H. (Nat. Struct. Mol. Biol. 2005)
    6. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. (PubMed id 22961380)1, 2 Barbosa I....Le Hir H. (amp 2012)
    7. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. (PubMed id 18423201)1, 2 Ma X.M.... Blenis J. (Cell 2008)
    8. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. (PubMed id 16931718)1, 2 Andersen C.B.... Andersen G.R. (Science 2006)
    9. Exon-junction complex components specify distinct routes of nonsense- mediated mRNA decay with differential cofactor requirements. (PubMed id 16209946)1, 2 Gehring N.H.... Kulozik A.E. (Mol. Cell 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    External Searches for EIF4A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EIF4A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9775 HGNC: 18683 AceView: DDX48 Ensembl:ENSG00000141543 euGenes: HUgn9775
    ECgene: EIF4A3 Kegg: 9775 H-InvDB: EIF4A3

    Other Databases showing EIF4A3 gene

    (According to HUGE)
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    HUGE: KIAA0111

    Specialized Databases showing EIF4A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF4A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EIF4A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for EIF4A3 gene:
    Search GeneIP for patents involving EIF4A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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