Aliases for EIF4A3 Gene
Aliases for EIF4A3 Gene
- Eukaryotic Translation Initiation Factor 4A3 2 3 5
- Eukaryotic Initiation Factor 4A-Like NUK-34 3 4
- DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 48 2 3
- ATP-Dependent RNA Helicase EIF4A-3 3 4
- ATP-Dependent RNA Helicase DDX48 3 4
- Nuclear Matrix Protein 265 3 4
- DEAD Box Protein 48 3 4
- EIF-4A-III 3 4
- EIF4A-III 3 4
- HNMP 265 3 4
- NMP 265 3 4
- DDX48 3 4
- Eukaryotic Translation Initiation Factor 4A, Isoform 3 2
External Ids for EIF4A3 Gene
- HGNC: 18683
- Entrez Gene: 9775
- Ensembl: ENSG00000141543
- OMIM: 608546
- UniProtKB: P38919
Previous HGNC Symbols for EIF4A3 Gene
- DDX48
Previous GeneCards Identifiers for EIF4A3 Gene
- GC17M075724
- GC17M078109
- GC17M073549
Summaries for EIF4A3 Gene
-
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]
GeneCards Summary for EIF4A3 Gene
EIF4A3 (Eukaryotic Translation Initiation Factor 4A3) is a Protein Coding gene. Diseases associated with EIF4A3 include Robin Sequence With Cleft Mandible And Limb Anomalies and Waterhouse-Friderichsen Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA binding. An important paralog of this gene is EIF4A2.
UniProtKB/Swiss-Prot for EIF4A3 Gene
-
ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. Involved in craniofacial development.
Additional gene information for EIF4A3 Gene
- Monarch Initiative
- Search for EIF4A3 at DataMed
- Search for EIF4A3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4A3 Gene
Genomics for EIF4A3 Gene
GeneHancer (GH) Regulatory Elements for EIF4A3 Gene
- Top Transcription factor binding sites by QIAGEN in the EIF4A3 gene promoter:
Regulatory Element Products
Genomic Locations for EIF4A3 Gene
- chr17:80,135,214-80,147,183
- (GRCh38/hg38)
- Size:
- 11,970 bases
- Orientation:
- Minus strand
- chr17:78,109,013-78,120,982
- (GRCh37/hg19)
Genomic View for EIF4A3 Gene
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC


RefSeq DNA sequence for EIF4A3 Gene
Proteins for EIF4A3 Gene
-
Protein details for EIF4A3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P38919-IF4A3_HUMAN
- Recommended name:
- Eukaryotic initiation factor 4A-III
- Protein Accession:
- P38919
- Q15033
- Q6IBQ2
- Q96A18
Protein attributes for EIF4A3 Gene
- Size:
- 411 amino acids
- Molecular mass:
- 46871 Da
- Quaternary structure:
-
- Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. Identified in the spliceosome C complex. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA-independent manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA. Interacts with NCBP3 (PubMed:26382858).
- SequenceCaution:
-
- Sequence=BAA04879.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for EIF4A3 Gene
Selected DME Specific Peptides for EIF4A3 Gene
- P38919:
-
- TITQAVIFC
- HACIGGT
- IKMLVLDEAD
- FEKPSAIQQR
- VLISTDV
- RKVDWLT
- ILVKRDELTLEG
- LISATLP
- WKFDTLCD
- LEMTNKF
- LAPTREL
- DPIRILVK
- ELTLEGI
- RVLISTD
- LLRGIYAY
- GFKEQIY
- LLALGDYMNVQCH
- SATLPHEILEMT
- YSTQIDEMP
- EMPMNVADL
- GRKGVAI
- SVLQCLDIQ
- TRELAVQ
- RILRDIE
- LRTRAIK
- FTVSSMHG
- GEDIRKL
- VDVTPTF
- GVAINFV
- APTRELA
- GTPGRVFDM
- DEADEML
- EQIYDVYRYLPPATQV
- IMKEFRSG
- AIKQIIKGRDVIAQSQSGTGKTATF
- YIHRIGR
Post-translational modifications for EIF4A3 Gene
- Ubiquitination at Lys198, Lys314, Lys374, and posLast=382382
Other Protein References for EIF4A3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for EIF4A3 (DDX48)
- Novus Biologicals Antibodies for EIF4A3
-
Abcam antibodies for EIF4A3
- Invitrogen Antibodies for EIF4A3
- GeneTex EIF4A3 antibody for EIF4A3
-
Santa Cruz Biotechnology (SCBT) Antibodies for EIF4A3
Protein Products
-
OriGene Purified Proteins for EIF4A3
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF4A3
- Origene Custom Protein Services for EIF4A3
- ProSpec Recombinant Proteins for EIF4A3
- Search GeneTex for Proteins for EIF4A3
-
Abcam proteins for EIF4A3
Assay Products
- antibodies-online: Search results for 1 available EIF4A3 Elisa Kits ranked by validation data
- Compare Top EIF4A3 Elisa Kits
-
Quality Products:
Domains & Families for EIF4A3 Gene
Gene Families for EIF4A3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
- Transporters
Protein Domains for EIF4A3 Gene
Suggested Antigen Peptide Sequences for EIF4A3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P38919- Family:
-
- Belongs to the DEAD box helicase family. eIF4A subfamily.
Function for EIF4A3 Gene
Molecular function for EIF4A3 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The ATPase activity is increased some 4-fold in the presence of RNA.
- UniProtKB/Swiss-Prot Function:
- ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. Involved in craniofacial development.
Enzyme Numbers (IUBMB) for EIF4A3 Gene
Phenotypes From GWAS Catalog for EIF4A3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | HDA,IEA | 22658674 |
GO:0003729 | mRNA binding | IDA | 22961380 |
GO:0004004 | ATP-dependent RNA helicase activity | IDA | 10523622 |
GO:0004386 | helicase activity | IEA | -- |
Phenotypes for EIF4A3 Gene
- GenomeRNAi human phenotypes for EIF4A3:
-
- Mitotic spindle defects
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Synthetic lethal with Ras
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Decreased shRNA abundance (Z-score < -2)
- Nucleoplasmic pre-40S maturation defects
- Wnt reporter downregulated
- Increased number of mitotic cells
- Decreased influenza A/WSN/33 replication
- Increased Nanog expression
- Increased Sindbis virus (SINV) infection
- Reduced shRNA abundance in FBW7 KO line
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Mitotic arrest, spindle defect
- Downregulation of NFkappaB pathway
- Nuclear 40S maturation defects
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EIF4A3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EIF4A3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
- Search ViGene Biosciences for EIF4A3
CRISPR Products
-
OriGene CRISPR knockouts for EIF4A3
- genomics-online: gRNA clones - Search results for available EIF4A3 gene related products
- Applied Biological Materials CRISPR for EIF4A3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF4A3
- GenScript: Design CRISPR guide RNA sequences for EIF4A3
miRNA for EIF4A3 Gene
- miRTarBase miRNAs that target EIF4A3
-
- hsa-mir-26b-5p (MIRT030151)
- hsa-mir-877-3p (MIRT036955)
- hsa-mir-18a-3p (MIRT040853)
- hsa-mir-324-3p (MIRT042843)
- hsa-mir-331-3p (MIRT043493)
- hsa-mir-99b-5p (MIRT044207)
- hsa-mir-183-5p (MIRT047149)
- hsa-mir-3115 (MIRT545408)
- hsa-mir-6739-5p (MIRT545409)
- hsa-mir-6733-5p (MIRT545410)
- hsa-mir-3153 (MIRT545411)
- hsa-mir-4668-5p (MIRT545412)
- hsa-mir-593-5p (MIRT545413)
- hsa-mir-3976 (MIRT545414)
- hsa-mir-6871-5p (MIRT545415)
- hsa-mir-6124 (MIRT561063)
- hsa-mir-8087 (MIRT561064)
- hsa-mir-513c-3p (MIRT561065)
- hsa-mir-513a-3p (MIRT561066)
- hsa-mir-3606-3p (MIRT561067)
- hsa-mir-561-3p (MIRT561068)
- hsa-mir-7161-5p (MIRT561069)
- hsa-mir-548u (MIRT561070)
- hsa-mir-665 (MIRT681772)
- hsa-mir-6780a-5p (MIRT681773)
- hsa-mir-6779-5p (MIRT681774)
- hsa-mir-3689c (MIRT681775)
- hsa-mir-3689b-3p (MIRT681776)
- hsa-mir-3689a-3p (MIRT681777)
- hsa-mir-30b-3p (MIRT681778)
- hsa-mir-1273h-5p (MIRT681779)
- hsa-mir-6778-5p (MIRT681780)
- hsa-mir-1233-5p (MIRT681781)
- hsa-mir-6799-5p (MIRT681782)
- hsa-mir-6883-5p (MIRT681783)
- hsa-mir-6785-5p (MIRT681784)
- hsa-mir-4728-5p (MIRT681785)
- hsa-mir-149-3p (MIRT681786)
- hsa-mir-7106-5p (MIRT681787)
- hsa-mir-3622b-5p (MIRT681788)
- hsa-mir-7160-5p (MIRT681789)
- hsa-mir-202-3p (MIRT681790)
- hsa-mir-98-5p (MIRT681791)
- hsa-mir-4500 (MIRT681792)
- hsa-mir-4458 (MIRT681793)
- hsa-let-7i-5p (MIRT681794)
- hsa-let-7g-5p (MIRT681795)
- hsa-let-7f-5p (MIRT681796)
- hsa-let-7e-5p (MIRT681797)
- hsa-let-7d-5p (MIRT681798)
- hsa-let-7c-5p (MIRT681799)
- hsa-let-7b-5p (MIRT681800)
- hsa-let-7a-5p (MIRT681801)
- hsa-mir-6884-5p (MIRT681802)
- hsa-mir-485-5p (MIRT681803)
- hsa-mir-7162-3p (MIRT681804)
- hsa-mir-4478 (MIRT681805)
- hsa-mir-4419b (MIRT681806)
- hsa-mir-3929 (MIRT681807)
- hsa-mir-6888-5p (MIRT681808)
- hsa-mir-5197-5p (MIRT681809)
miRNA Products
- Search ViGene Biosciences for EIF4A3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EIF4A3
- Browse OriGene Inhibitory RNA Products For EIF4A3
- genomics-online: shRNA clones - Search results for available EIF4A3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
Clone Products
- Sino Biological Human cDNA Clone for EIF4A3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EIF4A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EIF4A3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EIF4A3
- genomics-online: cdna clones - Search results for available EIF4A3 gene related products
- orf clones - Search results for available EIF4A3 gene related products
- Applied Biological Materials Clones for EIF4A3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EIF4A3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EIF4A3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4A3 Gene
Localization for EIF4A3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EIF4A3 Gene
- Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). {ECO:0000250}.
- Nucleoplasm (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005681 | spliceosomal complex | IEA | -- |
GO:0005730 | nucleolus | IBA | -- |
GO:0005737 | cytoplasm | IDA | 10523622 |
Pathways & Interactions for EIF4A3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.50
|
2 | RNA Polymerase II Transcription Termination | ||
3 | Transport of the SLBP independent Mature mRNA | ||
4 | Deadenylation-dependent mRNA decay | ||
5 | Viral mRNA Translation |
Pathways by source for EIF4A3 Gene
1 Cell Signaling Technology pathway for EIF4A3 Gene
3 KEGG pathways for EIF4A3 Gene
Interacting Proteins for EIF4A3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS | -- |
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006364 | rRNA processing | IEA | -- |
GO:0006369 | termination of RNA polymerase II transcription | TAS | -- |
No data available for SIGNOR curated interactions for EIF4A3 Gene
Drugs & Compounds for EIF4A3 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for EIF4A3 Gene
mRNA/cDNA for EIF4A3 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (521) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EIF4A3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EIF4A3
- genomics-online: gRNA clones - Search results for available EIF4A3 gene related products
- Applied Biological Materials CRISPR for EIF4A3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF4A3
- GenScript: Design CRISPR guide RNA sequences for EIF4A3
miRNA Products
- Search ViGene Biosciences for EIF4A3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EIF4A3
- Browse OriGene Inhibitory RNA Products For EIF4A3
- genomics-online: shRNA clones - Search results for available EIF4A3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
Clone Products
- Sino Biological Human cDNA Clone for EIF4A3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EIF4A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EIF4A3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EIF4A3
- genomics-online: cdna clones - Search results for available EIF4A3 gene related products
- orf clones - Search results for available EIF4A3 gene related products
- Applied Biological Materials Clones for EIF4A3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||
SP7: |
Expression for EIF4A3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF4A3 Gene
NURSA nuclear receptor signaling pathways regulating expression of EIF4A3 Gene:
EIF4A3SOURCE GeneReport for Unigene cluster for EIF4A3 Gene:
Hs.389649mRNA Expression by UniProt/SwissProt for EIF4A3 Gene:
P38919-IF4A3_HUMANEvidence on tissue expression from TISSUES for EIF4A3 Gene
- Nervous system(4.7)
- Skin(4.5)
- Blood(4.4)
- Bone marrow(4.4)
- Heart(4.3)
- Lung(3.4)
- Intestine(2.3)
- Lymph node(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4A3 Gene
- ectoderm
- endoderm
- mesoderm
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- chin
- ear
- face
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- pharynx
- skull
- tongue
- tooth
- vocal cord
- esophagus
- lung
- trachea
- ankle
- arm
- digit
- finger
- foot
- forearm
- hand
- lower limb
- radius
- shin
- tibia
- toe
- upper limb
- skin
Primer Products
-
OriGene qPCR primer pairs for EIF4A3
-
OriGene qPCR primer pairs and template standards for EIF4A3
- genomics-online: primer clones - Search results for available EIF4A3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for EIF4A3 Gene
Orthologs for EIF4A3 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
chimpanzee (Pan troglodytes) |
Mammalia | EIF4A3 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Gm8994 34 |
|
OneToMany | |
Eif4a3 33 16 34 |
|
||||
platypus (Ornithorhynchus anatinus) |
Mammalia | EIF4A3 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | EIF4A3 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | EIF4A3 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Eif4a3 33 |
|
||
chicken (Gallus gallus) |
Aves | EIF4A3 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | EIF4A3 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | eif4a3 33 |
|
||
Str.1107 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.755 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | eif4a3 33 34 |
|
||
zgc56139 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1301 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | eIF4AIII 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003089 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | F33D11.10 34 |
|
OneToMany | |
Y65B4A.6 33 34 |
|
||||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER408W 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FAL1 33 34 36 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A10659g 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | EIF4A-III 33 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1139 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os03g0566800 33 |
|
||
Os.11991 33 |
|
||||
barley (Hordeum vulgare) |
Liliopsida | Hv.6810 33 |
|
||
wheat (Triticum aestivum) |
Liliopsida | Ta.4227 33 |
|
||
corn (Zea mays) |
Liliopsida | Zm.16778 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7891 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU01234 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1F5.10 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2350 33 |
|
- Species where no ortholog for EIF4A3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for EIF4A3 Gene
(33) SIMAP similar genes for EIF4A3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for EIF4A3 Gene
Variants for EIF4A3 Gene
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs587777204 | pathogenic, Richieri Costa Pereira syndrome, Richieri-Costa-Pereira syndrome (RCPS) [MIM:268305] | 80,138,200(-) | T/C | coding_sequence_variant, missense_variant | |
rs1000173409 | -- | 80,145,708(-) | T/C | intron_variant | |
rs1000786144 | -- | 80,148,291(-) | C/G | upstream_transcript_variant | |
rs1000823935 | -- | 80,136,137(-) | G/A | intron_variant | |
rs1000922139 | -- | 80,148,472(-) | G/C | upstream_transcript_variant |
Additional Variant Information for EIF4A3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4A3 Gene
Disorders for EIF4A3 Gene

(5) MalaCards diseases for EIF4A3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, and DISEASES
Disorder | Aliases | PubMed IDs |
---|---|---|
robin sequence with cleft mandible and limb anomalies |
|
|
waterhouse-friderichsen syndrome |
|
|
bowen-conradi syndrome |
|
|
vaginal cancer |
|
|
acrofacial dysostosis |
|
|
UniProtKB/Swiss-Prot
IF4A3_HUMAN- Richieri-Costa-Pereira syndrome (RCPS) [MIM:268305]: A syndrome characterized by a unique pattern of anomalies consisting of microstomia, micrognathia, abnormal fusion of mandible, cleft palate/Robin sequence, absence of central lower incisors, minor ears anomalies, hypoplastic first ray, abnormal tibiae, hypoplastic halluces, and clubfeet. Learning disability is also a common finding. {ECO:0000269 PubMed:24360810}. Note=The disease is caused by mutations affecting the gene represented in this entry. EIF4A3 mutations resulting in Richieri-Costa-Pereira syndrome include a repeat expansion of 18 or 20 nucleotides in the 5 untranslated region. Affected individuals have 14 to 16 repeats, while healthy individuals have 3 to 12 repeats (PubMed:24360810). {ECO:0000269 PubMed:24360810}.
Additional Disease Information for EIF4A3
No data available for Genatlas for EIF4A3 Gene
Publications for EIF4A3 Gene
- A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. (PMID: 10623621) Holzmann K … Sauermann G (Biochemical and biophysical research communications 2000) 2 3 4 22 58
- The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. (PMID: 16923391) Bono F … Conti E (Cell 2006) 3 4 22 58
- The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PMID: 16170325) Ballut L … Le Hir H (Nature structural & molecular biology 2005) 3 4 22 58
- eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. (PMID: 15034551) Shibuya T … Moore MJ (Nature structural & molecular biology 2004) 3 4 22 58
- eIF4A3 is a novel component of the exon junction complex. (PMID: 14730019) Chan CC … Dreyfuss G (RNA (New York, N.Y.) 2004) 2 3 4 58
Products for EIF4A3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EIF4A3
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF4A3
- Origene Custom Protein Services for EIF4A3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF4A3
- Browse OriGene Inhibitory RNA Products For EIF4A3
- OriGene qPCR primer pairs and template standards for EIF4A3
- OriGene qPCR primer pairs for EIF4A3
- OriGene CRISPR knockouts for EIF4A3
- OriGene ORF clones in human for EIF4A3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EIF4A3
- GenScript: Next-day shipping of latest version cDNA ORF clones for EIF4A3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for EIF4A3
- GenScript Custom Assay Services for EIF4A3
- GenScript Custom overexpressing Cell Line Services for EIF4A3
- GenScript: Design CRISPR guide RNA sequences for EIF4A3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EIF4A3
- Cell Signaling Technology (CST) Antibodies for EIF4A3 (DDX48)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for EIF4A3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for EIF4A3
- Novus Biologicals lysates and proteins for EIF4A3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for EIF4A3
- Abcam proteins for EIF4A3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for EIF4A3
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for EIF4A3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for EIF4A3
- VectorBuilder custom plasmid, inducible vectors for EIF4A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EIF4A3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EIF4A3
- antibodies-online: Search results for 53 available EIF4A3 Antibodies ranked by validation data
- Compare Top EIF4A3 Antibodies
- antibodies-online: Search results for 1 available EIF4A3 Elisa Kits ranked by validation data
- Compare Top EIF4A3 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 18 available EIF4A3 Proteins ranked by validation data
- Compare Top EIF4A3 Proteins
- GeneTex EIF4A3 antibody for EIF4A3
- Search GeneTex for Proteins for EIF4A3
- ViGene Biosciences adenoviral particle packaged cDNA for EIF4A3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EIF4A3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
- Search ViGene Biosciences for EIF4A3
- Santa Cruz Biotechnology (SCBT) Antibodies for EIF4A3
- Search Santa Cruz Biotechnology (SCBT) for EIF4A3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EIF4A3
- genomics-online: cdna clones - Search results for available EIF4A3 gene related products
- orf clones - Search results for available EIF4A3 gene related products
- genomics-online: gRNA clones - Search results for available EIF4A3 gene related products
- genomics-online: primer clones - Search results for available EIF4A3 gene related products
- genomics-online: shRNA clones - Search results for available EIF4A3 gene related products
Sources for EIF4A3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew