Aliases for EIF4A3 Gene
Aliases for EIF4A3 Gene
- Eukaryotic Translation Initiation Factor 4A3 2 3 5
- Eukaryotic Initiation Factor 4A-Like NUK-34 3 4
- DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 48 2 3
- ATP-Dependent RNA Helicase EIF4A-3 3 4
- ATP-Dependent RNA Helicase DDX48 3 4
- Nuclear Matrix Protein 265 3 4
- DEAD Box Protein 48 3 4
- EIF-4A-III 3 4
- EIF4A-III 3 4
- HNMP 265 3 4
- NMP 265 3 4
- DDX48 3 4
External Ids for EIF4A3 Gene
- HGNC: 18683
- Entrez Gene: 9775
- Ensembl: ENSG00000141543
- OMIM: 608546
- UniProtKB: P38919
Previous HGNC Symbols for EIF4A3 Gene
- DDX48
Previous GeneCards Identifiers for EIF4A3 Gene
- GC17M075724
- GC17M078109
- GC17M073549
Summaries for EIF4A3 Gene
-
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]
GeneCards Summary for EIF4A3 Gene
EIF4A3 (Eukaryotic Translation Initiation Factor 4A3) is a Protein Coding gene. Diseases associated with EIF4A3 include Robin Sequence With Cleft Mandible And Limb Anomalies and Vaginal Cancer. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and mRNA binding. An important paralog of this gene is EIF4A2.
UniProtKB/Swiss-Prot for EIF4A3 Gene
-
ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. Involved in craniofacial development.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4A3 Gene
Genomics for EIF4A3 Gene
Regulatory Elements for EIF4A3 Gene
Enhancers for EIF4A3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around EIF4A3 on UCSC Golden Path with GeneCards custom track
Promoters for EIF4A3 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around EIF4A3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the EIF4A3 gene promoter:
Regulatory Element Products
Genomic Location for EIF4A3 Gene
- Chromosome:
- 17
- Start:
- 80,135,214 bp from pter
- End:
- 80,147,183 bp from pter
- Size:
- 11,970 bases
- Orientation:
- Minus strand
Genomic View for EIF4A3 Gene
Genes around EIF4A3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
EIF4A3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EIF4A3 Gene
Proteins for EIF4A3 Gene
-
Protein details for EIF4A3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P38919-IF4A3_HUMAN
- Recommended name:
- Eukaryotic initiation factor 4A-III
- Protein Accession:
- P38919
- Q15033
- Q6IBQ2
- Q96A18
Protein attributes for EIF4A3 Gene
- Size:
- 411 amino acids
- Molecular mass:
- 46871 Da
- Quaternary structure:
-
- Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. Identified in the spliceosome C complex. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA-independent manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA. Interacts with NCBP3 (PubMed:26382858).
- SequenceCaution:
-
- Sequence=BAA04879.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for EIF4A3 Gene
Selected DME Specific Peptides for EIF4A3 Gene
- P38919:
-
- TITQAVIFC
- HACIGGT
- IKMLVLDEAD
- FEKPSAIQQR
- VLISTDV
- RKVDWLT
- ILVKRDELTLEG
- LISATLP
- WKFDTLCD
- LEMTNKF
- LAPTREL
- DPIRILVK
- ELTLEGI
- RVLISTD
- LLRGIYAY
- GFKEQIY
- LLALGDYMNVQCH
- SATLPHEILEMT
- YSTQIDEMP
- EMPMNVADL
- GRKGVAI
- SVLQCLDIQ
- TRELAVQ
- RILRDIE
- LRTRAIK
- FTVSSMHG
- GEDIRKL
- VDVTPTF
- GVAINFV
- APTRELA
- GTPGRVFDM
- DEADEML
- EQIYDVYRYLPPATQV
- IMKEFRSG
- AIKQIIKGRDVIAQSQSGTGKTATF
- YIHRIGR
Post-translational modifications for EIF4A3 Gene
Other Protein References for EIF4A3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for EIF4A3
- Cell Signaling Technology (CST) Antibodies for EIF4A3 (DDX48)
- Novus Biologicals Antibodies for EIF4A3
- Invitrogen Antibodies for EIF4A3
- antibodies-online Antibodies for EIF4A3: See all 48
- GeneTex EIF4A3 antibody for EIF4A3
-
Santa Cruz Biotechnology (SCBT) Antibodies for EIF4A3
Protein Products
-
OriGene Purified Proteins for EIF4A3
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF4A3
- Origene Custom Protein Services for EIF4A3
- ProSpec Recombinant Proteins for EIF4A3
- antibodies-online Proteins for EIF4A3: See all 18
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EIF4A3
Assay Products
Domains & Families for EIF4A3 Gene
Gene Families for EIF4A3 Gene
Protein Domains for EIF4A3 Gene
Suggested Antigen Peptide Sequences for EIF4A3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P38919UniProtKB/Swiss-Prot:
IF4A3_HUMAN :- Contains 1 helicase ATP-binding domain.
- Belongs to the DEAD box helicase family. eIF4A subfamily.
- Domain:
-
- Contains 1 helicase ATP-binding domain.
- Contains 1 helicase C-terminal domain.
- Family:
-
- Belongs to the DEAD box helicase family. eIF4A subfamily.
Function for EIF4A3 Gene
Molecular function for EIF4A3 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The ATPase activity is increased some 4-fold in the presence of RNA.
- UniProtKB/Swiss-Prot Function:
- ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. Involved in craniofacial development.
Enzyme Numbers (IUBMB) for EIF4A3 Gene
- EC 3.6.1 63
- EC 3.6.4.13 4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 10523622 |
| GO:0008143 | poly(A) binding | IDA | 10523622 |
| GO:0035368 | selenocysteine insertion sequence binding | IEA | -- |
Phenotypes for EIF4A3 Gene
- GenomeRNAi human phenotypes for EIF4A3:
-
- Mitotic spindle defects
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with Ras
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Decreased shRNA abundance (Z-score < -2)
- Nucleoplasmic pre-40S maturation defects
- Decreased viability
- Wnt reporter downregulated
- Increased number of mitotic cells
- Decreased influenza A/WSN/33 replication
- Increased Sindbis virus (SINV) infection
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Mitotic arrest, spindle defect
- Downregulation of NFkappaB pathway
- Nuclear 40S maturation defects
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for EIF4A3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
- Search ViGene Biosciences for EIF4A3
CRISPR Products
-
OriGene CRISPR knockouts for EIF4A3
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF4A3
- GenScript: Design CRISPR guide RNA sequences for EIF4A3
miRNA for EIF4A3 Gene
- miRTarBase miRNAs that target EIF4A3
-
- hsa-mir-26b-5p (MIRT030151)
- hsa-mir-877-3p (MIRT036955)
- hsa-mir-18a-3p (MIRT040853)
- hsa-mir-324-3p (MIRT042843)
- hsa-mir-331-3p (MIRT043493)
- hsa-mir-99b-5p (MIRT044207)
- hsa-mir-183-5p (MIRT047149)
- hsa-mir-3115 (MIRT545408)
- hsa-mir-6739-5p (MIRT545409)
- hsa-mir-6733-5p (MIRT545410)
- hsa-mir-3153 (MIRT545411)
- hsa-mir-4668-5p (MIRT545412)
- hsa-mir-593-5p (MIRT545413)
- hsa-mir-3976 (MIRT545414)
- hsa-mir-6871-5p (MIRT545415)
- hsa-mir-6124 (MIRT561063)
- hsa-mir-8087 (MIRT561064)
- hsa-mir-513c-3p (MIRT561065)
- hsa-mir-513a-3p (MIRT561066)
- hsa-mir-3606-3p (MIRT561067)
- hsa-mir-561-3p (MIRT561068)
- hsa-mir-7161-5p (MIRT561069)
- hsa-mir-548u (MIRT561070)
- hsa-mir-665 (MIRT681772)
- hsa-mir-6780a-5p (MIRT681773)
- hsa-mir-6779-5p (MIRT681774)
- hsa-mir-3689c (MIRT681775)
- hsa-mir-3689b-3p (MIRT681776)
- hsa-mir-3689a-3p (MIRT681777)
- hsa-mir-30b-3p (MIRT681778)
- hsa-mir-1273h-5p (MIRT681779)
- hsa-mir-6778-5p (MIRT681780)
- hsa-mir-1233-5p (MIRT681781)
- hsa-mir-6799-5p (MIRT681782)
- hsa-mir-6883-5p (MIRT681783)
- hsa-mir-6785-5p (MIRT681784)
- hsa-mir-4728-5p (MIRT681785)
- hsa-mir-149-3p (MIRT681786)
- hsa-mir-7106-5p (MIRT681787)
- hsa-mir-3622b-5p (MIRT681788)
- hsa-mir-7160-5p (MIRT681789)
- hsa-mir-202-3p (MIRT681790)
- hsa-mir-98-5p (MIRT681791)
- hsa-mir-4500 (MIRT681792)
- hsa-mir-4458 (MIRT681793)
- hsa-let-7i-5p (MIRT681794)
- hsa-let-7g-5p (MIRT681795)
- hsa-let-7f-5p (MIRT681796)
- hsa-let-7e-5p (MIRT681797)
- hsa-let-7d-5p (MIRT681798)
- hsa-let-7c-5p (MIRT681799)
- hsa-let-7b-5p (MIRT681800)
- hsa-let-7a-5p (MIRT681801)
- hsa-mir-6884-5p (MIRT681802)
- hsa-mir-485-5p (MIRT681803)
- hsa-mir-7162-3p (MIRT681804)
- hsa-mir-4478 (MIRT681805)
- hsa-mir-4419b (MIRT681806)
- hsa-mir-3929 (MIRT681807)
- hsa-mir-6888-5p (MIRT681808)
- hsa-mir-5197-5p (MIRT681809)
miRNA Products
- Search ViGene Biosciences for EIF4A3
Clone Products
- OriGene clones in human for EIF4A3
- OriGene ORF clones in human,mouse,rat for EIF4A3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF4A3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EIF4A3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EIF4A3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
Flow Cytometry Products
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4A3 Gene
Localization for EIF4A3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EIF4A3 Gene
- Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 5 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 10523622 |
| GO:0016020 | membrane | IDA | 19946888 |
| GO:0030425 | dendrite | IEA | -- |
| GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
Pathways & Interactions for EIF4A3 Gene
More details on SuperPathways for EIF4A3| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.74
|
.43
|
| 2 | RNA Polymerase II Transcription Termination | ||
| 3 | Regulation of Glucokinase by Glucokinase Regulatory Protein | ||
| 4 | Deadenylation-dependent mRNA decay | ||
| 5 | Viral mRNA Translation |
Pathways by source for EIF4A3 Gene
1 Cell Signaling Technology pathway for EIF4A3 Gene
1 BioSystems pathway for EIF4A3 Gene
19 Reactome pathways for EIF4A3 Gene
3 KEGG pathways for EIF4A3 Gene
Interacting Proteins for EIF4A3 Gene
Selected Interacting proteins:
P38919-IF4A3_HUMAN
ENSP00000269349
for EIF4A3 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | IC,TAS | -- |
| GO:0006364 | rRNA processing | IEA | -- |
| GO:0006369 | termination of RNA polymerase II transcription | TAS | -- |
| GO:0006406 | mRNA export from nucleus | TAS | -- |
| GO:0008380 | RNA splicing | IBA | -- |
No data available for SIGNOR curated interactions for EIF4A3 Gene
Drugs & Compounds for EIF4A3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| phosphoric acid |
|
7664-38-2 |
|
|||
| Water |
|
7732-18-5 |
|
Transcripts for EIF4A3 Gene
mRNA/cDNA for EIF4A3 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (521) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EIF4A3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EIF4A3
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF4A3
- GenScript: Design CRISPR guide RNA sequences for EIF4A3
miRNA Products
- Search ViGene Biosciences for EIF4A3
Clone Products
- OriGene clones in human for EIF4A3
- OriGene ORF clones in human,mouse,rat for EIF4A3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF4A3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for EIF4A3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4A3 Gene
SOURCE GeneReport for Unigene cluster for EIF4A3 Gene Hs.389649
mRNA Expression by UniProt/SwissProt for EIF4A3 Gene
P38919-IF4A3_HUMAN
Tissue specificity:
Ubiquitously expressed.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for EIF4A3
-
OriGene qPCR primer pairs and template standards for EIF4A3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for EIF4A3 Gene
Orthologs for EIF4A3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | EIF4A3 35 |
|
||
| EIF4A3 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | EIF4A3 35 |
|
||
| EIF4A3 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Eif4a3 35 |
|
||
| Eif4a3 16 |
|
||||
| Eif4a3 36 |
|
OneToMany | |||
| Gm8994 36 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | EIF4A3 35 |
|
||
| EIF4A3 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Eif4a3 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EIF4A3 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EIF4A3 35 |
|
||
| EIF4A3 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | EIF4A3 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eif4a3 35 |
|
||
| Str.1107 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.755 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | eif4a3 35 |
|
||
| zgc56139 35 |
|
||||
| eif4a3 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1301 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003089 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | eIF4AIII 35 |
|
||
| eIF4AIII 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | Y65B4A.6 35 |
|
||
| F33D11.10 36 |
|
OneToMany | |||
| Y65B4A.6 36 |
|
OneToMany | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER408W 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A10659g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FAL1 35 |
|
||
| FAL1 36 |
|
OneToMany | |||
| FAL1 38 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | EIF4A-III 35 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1139 35 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.6810 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.11991 35 |
|
||
| Os03g0566800 35 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.4227 35 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.16778 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2350 35 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01234 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1F5.10 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7891 36 |
|
OneToOne |
- Species with no ortholog for EIF4A3:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for EIF4A3 Gene
(33) SIMAP similar genes for EIF4A3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for EIF4A3 Gene
Variants for EIF4A3 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_071090 | Richieri-Costa-Pereira syndrome (RCPS) | ||||
| rs935117 | -- | 80,141,685(+) | TAGAA(A/C)ATTTT | intron-variant | |
| rs1804078 | -- | 80,137,496(-) | GTGGA(C/T)TGGCT | reference, synonymous-codon | |
| rs1804079 | -- | 80,136,115(-) | CAGGT(C/G)GATAC | reference, missense | |
| rs2241886 | -- | 80,140,033(-) | GTTGT(C/T)GCGGG | reference, synonymous-codon |
Residual Variation Intolerance Score:
18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.35;
7.70% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EIF4A3 Gene
- Human Gene Mutation Database (HGMD)
- EIF4A3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4A3 Gene
Disorders for EIF4A3 Gene
(4) MalaCards diseases for EIF4A3 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| robin sequence with cleft mandible and limb anomalies |
|
|
| vaginal cancer |
|
|
| acrofacial dysostosis 1, nager type |
|
|
| learning disability |
|
|
Search EIF4A3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IF4A3_HUMAN- Richieri-Costa-Pereira syndrome (RCPS) [MIM:268305]: A syndrome characterized by a unique pattern of anomalies consisting of microstomia, micrognathia, abnormal fusion of mandible, cleft palate/Robin sequence, absence of central lower incisors, minor ears anomalies, hypoplastic first ray, abnormal tibiae, hypoplastic halluces, and clubfeet. Learning disability is also a common finding. {ECO:0000269 PubMed:24360810}. Note=The disease is caused by mutations affecting the gene represented in this entry. EIF4A3 mutations resulting in Richieri-Costa-Pereira syndrome include a repeat expansion of 18 or 20 nucleotides in the 5 untranslated region. Affected individuals have 14 to 16 repeats, while healthy individuals have 3 to 12 repeats (PubMed:24360810). {ECO:0000269 PubMed:24360810}.
Relevant External Links for EIF4A3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- EIF4A3
No data available for Genatlas for EIF4A3 Gene
Publications for EIF4A3 Gene
- A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. (PMID: 10623621) Holzmann K. … Sauermann G. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23 67
- Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. (PMID: 16452507) Kashima I. … Ohno S. (Genes Dev. 2006) 3 23
- The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. (PMID: 16923391) Bono F. … Conti E. (Cell 2006) 3 23
- The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PMID: 16170325) Ballut L. … Le Hir H. (Nat. Struct. Mol. Biol. 2005) 3 23
- eIF4A3 is a novel component of the exon junction complex. (PMID: 14730019) Chan C.C. … Dreyfuss G. (RNA 2004) 2 3
Products for EIF4A3 Gene
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- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for EIF4A3
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- OriGene qPCR primer pairs for EIF4A3
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- OriGene CRISPR knockouts for EIF4A3
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- OriGene ORF clones in human,mouse,rat for EIF4A3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Cell Signaling Technology (CST) Antibodies for EIF4A3 (DDX48)
- Search for Antibodies & Assays
- Novus Biologicals Antibodies for EIF4A3
- Novus Biologicals proteins and lysates for EIF4A3
- Novus Biologicals
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- ProSpec Recombinant Proteins for EIF4A3
- antibodies-online Antibodies for EIF4A3: See all 48
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- antibodies-online Proteins for EIF4A3: See all 18
- Search antibodies-online for peptides
- GeneTex EIF4A3 antibody for EIF4A3
- Search GeneTex for Proteins for EIF4A3
- ViGene Biosciences adenoviral particle packaged cDNA for EIF4A3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EIF4A3 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EIF4A3 gene
- Search ViGene Biosciences for EIF4A3
- Search ViGene Biosciences for EIF4A3
- Santa Cruz Biotechnology (SCBT) Antibodies for EIF4A3
- Search Santa Cruz Biotechnology (SCBT) for EIF4A3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EIF4A3
Sources for EIF4A3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (24) PharmGKB
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- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
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- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
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- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
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- (118) PathCards
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- (149) ENCODE
- (150) ProSci
- (151) Horizon