EIF4A2 Gene
protein-coding GIFtS: 65
GCID: GC03P186548
|
|
eukaryotic translation initiation factor 4A2(Previous names: eukaryotic translation initiation factor 4A, isoform 2...)
(Previous symbol: EIF4F)
| |
Aliases
for EIF4A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 4A21 2 | | EIF4A-II1 | | DDX2B1 2 3 | | Eukaryotic Translation Initiation Factor 4A, Isoform 21 | | EIF4F1 2 3 | | Eukaryotic Initiation Factor 4A-II2 | | BM-0101 2 | | Eukaryotic Translation Initiation Factor 4A2 | | EIF4A1 2 | | EC 3.6.4.133 | | ATP-Dependent RNA Helicase EIF4A-22 3 | | EC 3.6.18 | | EIF-4A-II1 | | |
Export aliases for EIF4A2 gene to outside databasesPrevious GC identifers: GC03P183276 GC03P187758 GC03P187903 GC03P187822 GC03P187984 GC03P186503 GC03P186522 GC03P186528 GC03P186533 GC03P186539 |
Summaries
for EIF4A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and isrequired for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondarystructures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, andsubsequent scanning for the initiator codon
Gene Wiki entry for EIF4A2
|
Genomic Views
for EIF4A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EIF4A2 gene promoter:
Elk-1 SREBP-1c Lmo2 STAT5A Meis-1b SREBP-1b Evi-1 E2F Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF4A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF4A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q28 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q28EIF4A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P186548: view genomic region
(about GC identifiers)
Start:
|
186,500,994 bp from pter |
End:
|
186,507,689 bp from pter |
Size:
|
6,696 bases |
Orientation:
|
plus strand |
|
Proteins
for EIF4A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240 (See
protein sequence)Recommended Name: Eukaryotic initiation factor 4A-II Size: 407 amino acids; 46402 Da
Subunit: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmentalconditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. Mayinteract with NOM1. Interacts with HHV-1 Vhs
1 PDB 3D structure from  and Proteopedia  for EIF4A2:3BOR (3D)
Secondary accessions: D3DNU9 Q53XJ6 Q96B90 Q96EA8Alternative splicing: 2 isoforms: Q14240-1 Q14240-2 Explore the universe of human proteins at neXtProt for EIF4A2: NX_Q14240
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14240
4/43 DME Specific Peptides for EIF4A2 (Q14240) (see all 43)
EIF4A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001958.2
ENSEMBL proteins: ENSP00000407504 ENSP00000415878 ENSP00000326381 ENSP00000392686 ENSP00000388237 ENSP00000413529 ENSP00000398370 ENSP00000402313 ENSP00000462571 ENSP00000348925 Reactome Protein details: Q14240
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- | | GO:0016281 | eukaryotic translation initiation factor 4F complex |
TAS | 8521730 |
EIF4A2 for ontologies About GeneDecksing
EIF4A2 Antibody Products:
Assay Products for EIF4A2: |
Protein
Domains /
Families
for EIF4A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF4A2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14240ProtoNet protein and cluster: Q14240 1 Blocks protein family: IPB000629 ATP-dependent helicase
UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240Similarity: Belongs to the DEAD box helicase family. eIF4A subfamilySimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain |
Function
for EIF4A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and isrequired for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondarystructures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, andsubsequent scanning for the initiator codonCatalytic activity: ATP + H(2)O = ADP + phosphate Genatlas biochemistry entry for EIF4A2:eukaryotic,cap structure,translation initiation factor EIF4A,isoform 2,involved in the binding of mRNA toribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family
Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4A2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EIF4A2 (NM_001967) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF4A2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4A2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4A2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
EIF4A2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for EIF4A2:
Animal Models:
1 MGI phenotypic allele  for Eif4a2 (no phenotypes)
EIF4A2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for EIF4A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Development_CNTF receptor signaling | | | 3 | Translation initiation complex formation | | | 4 | Translation_Translation regulation by Alpha-1 adrenergic receptors | | | 5 | Cytokine Signaling in Immune system | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for EIF4A2
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF4A2
1 
Cell Signaling Technology (CST) Pathway for EIF4A2
3  GeneGo (Thomson Reuters) Pathways for EIF4A2
1  BioSystems Pathway for EIF4A2
5/21 
Reactome Pathways for EIF4A2 (see all 21)
1 
Kegg Pathway (Kegg details for EIF4A2):
EIF4A2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF4A2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/596 Interacting proteins for EIF4A2 (Q142401, 2, 3 ENSP000003263814) via UniProtKB, MINT, STRING, and/or I2D (see all 596)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006446 | regulation of translational initiation |
TAS | 8521730 |
EIF4A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for EIF4A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EIF4A2 for compounds About GeneDecksing
 Browse Tocris compounds for EIF4A2
1 Novoseek chemical compound relationship for EIF4A2 gene About this table
Search CenterWatch for drugs/clinical trials and news about EIF4A2 / IF4A2
|
Transcripts
for EIF4A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EIF4A2 gene: NM_001967.3 Unigene Clusters for EIF4A2: Eukaryotic translation initiation factor 4A2 Hs.518475 [show with all ESTs], Hs.599481 [show with all ESTs]Unigene Representative Sequences: BC013708, BC03934418/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28): ENST00000441007 ENST00000445596 ENST00000323963(uc003fqs.3 uc003fqu.3)
ENST00000426808(uc003fqv.3 uc003fqw.3) ENST00000465222 ENST00000491473
ENST00000486805 ENST00000465032 ENST00000465267 ENST00000495049 ENST00000429589
ENST00000425053 ENST00000440191 ENST00000485101(uc011bsb.2) ENST00000475653
ENST00000443963 ENST00000498746 ENST00000467585
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4A2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EIF4A2 (NM_001967) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF4A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4A2 |
Additional cDNA sequence: BC039344.1 24/100 DOTS entries (see all 100): DT.100704120 DT.95366981 DT.95367045 DT.100861682 DT.92471170 DT.92471144 DT.92471199 DT.91813486 DT.120916005 DT.120915987 DT.100704110 DT.95367030 DT.214260 DT.100704107 DT.100704115 DT.85105316 DT.92471183 DT.120915819 DT.100059712 DT.100704083 DT.100704094 DT.100704092 DT.120915891 DT.120915972 16 AceView cDNA sequences: N79339 AI090838 BX118227 BG721373 BC039344 BG722642 AI969861 AA496083 BF979955 CD171717 N62248 AA406081 CD300445 BI463735 BI831749 BF979570
GeneLoc Exon Structure
5/25 Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A2 (see all 25) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | |
| SP5: | | | | | | | | | - | | - | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | |
| ExUns: | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e |
|---|
|
| SP1: | - | | | | - | | - | | | | | | | | | | | | |
| SP2: | - | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EIF4A2
|
Expression
for EIF4A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF4A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCGAAAAA
About this image
See EIF4A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF4A2
SOURCE GeneReport for Unigene clusters: Hs.518475 Hs.599481
SABiosciences Custom PCR Arrays for EIF4A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF4A2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF4A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF4A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF4A2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4A2 |
Orthologs
for EIF4A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF4A2 gene from 8/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
EIF4A21 |
eukaryotic translation initiation factor 4A2 |
88.37(n)
97.79(a) |
|
395232 NM_204549.1 NP_989880.1 |
lizard
(Anolis carolinensis) |
Reptilia |
EIF4A26 |
-- |
98(a) |
1 ↔ 1 |
GL343321.1(112558-123268) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC041252.12 |
-- |
83.29(n) |
|
BC041252.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufd50g112 |
Danio rerio cDNA clone MGC63783 IMAGE2643605, complete more |
79.38(n) |
|
BC055242.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
eIF-4a1 , 3 |
translational initiation translation
initiation more3
Eukaryotic initiation factor 4a1 |
73(a)3
66.92(n)1
74.05(a)1 |
|
338351 NM_057247.41 NP_476595.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
inf-11 , 3 |
Protein INF-11 |
71(a)
(best of 2)3
64.01(n)1
72.24(a)1 |
|
III(7001893-7003341)3
1759661 NM_001027452.11 NP_001022623.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
EIF4A11 |
translational initiation factor 4A-1 |
67.45(n)
72.97(a) |
|
820605 NM_112246.3 NP_566469.1 |
rice
(Oryza sativa) |
Liliopsida |
Os06g07011001 |
hypothetical protein |
68.15(n)
74.28(a) |
|
4341966 NM_001065016.1 NP_001058481.1 |
ENSEMBL Gene Tree for EIF4A2 (if available)
TreeFam Gene Tree for EIF4A2 (if available) |
Paralogs
for EIF4A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EIF4A2 gene
- EIF4A12 DDX202 EIF4A32
18/41 SIMAP similar genes for EIF4A2 using alignment to 8 protein entries: IF4A2_HUMAN (see all proteins)
(see all similar genes):EIF4A1 DKFZp566L241 EIF4A3 DKFZp547B159 DDX25 DDX6
BAT1 DDX39B DDX19A DDX39A DDX19B DKFZp762C1313
DDX19L DDX20 DDX43 DKFZp686C21137 DDX59 DDX53
EIF4A2 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for EIF4A2 (see all 6)
PGOHUM00000238838 PGOHUM00000238839 PGOHUM00000242296 PGOHUM00000242631 PGOHUM00000262941
|
Genomic Variants
for EIF4A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EIF4A2 (186500994 - 186507689 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for EIF4A2
3 CNVs: 47856 3467 32540 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF4A2 |
|
Disorders
/ Diseases
for EIF4A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EIF4A2 for disorders About GeneDecksing
OMIM gene information: 601102
OMIM disorders: --
12  diseases for EIF4A2: About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas acute myeloid leukemia herpes simplex
myeloid leukemia hepatitis c cholera leukemia
hepatitis pneumonia schizophrenia malaria
Export disorders for EIF4A2 gene to outside databases
|
Publications
for EIF4A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EIF4A2 gene, integrated from 9 sources (see all 84):
(articles sorted by number of sources associating them with EIF4A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. (PubMed id 8521730)1, 2, 3 Sudo K.... Nakamura Y. (1995)
- mRNA decay during herpes simplex virus (HSV) infections: protein- protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. (PubMed id 16014927)1, 2 Feng P.... Read G.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. (PubMed id 11408474)1, 2 Li W.... Proud C.G. (2001)
- Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. (PubMed id 11922617)1, 9 Kyono K....Taguchi I. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A cellular response linking eIF4AI activity to eIF4AII transcription. (PubMed id 22589333)1 Galicia-Vazquez G....Pelletier J. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- In vitro studies reveal that different modes of initia tion on HIV-1 mRNA have different levels of requirement for eukaryotic initiatio n factor 4F. (PubMed id 22759308)1 de Breyne S....Ohlmann T. (2012)
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External Searches for EIF4A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing EIF4A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing EIF4A2 gene
(According to HUGE)
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Specialized Databases showing EIF4A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for EIF4A2 gene:
Search GeneIP for patents involving EIF4A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EIF4A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EIF4A2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF4A2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF4A2 | | | OriGene Protein Over-expression Lysate for EIF4A2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EIF4A2 | | OriGene 3'-UTR Clone for EIF4A2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4A2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF4A2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EIF4A2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EIF4A2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF4A2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF4A2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF4A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF4A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF4A2 |
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| | Antibodies & Assays for EIF4A2 |
| | | | Search Tocris compounds for EIF4A2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4A2 |
|  |  |  | | | | ThermoFisher Antibody for EIF4A2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF4A2 |
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