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Aliases for EIF4A2 Gene

Aliases for EIF4A2 Gene

  • Eukaryotic Translation Initiation Factor 4A2 2 3
  • ATP-Dependent RNA Helicase EIF4A-2 3 4
  • EIF-4A-II 3 4
  • EIF4A-II 3 4
  • EIF4F 3 4
  • DDX2B 3 4
  • Eukaryotic Translation Initiation Factor 4A, Isoform 2 2
  • Eukaryotic Initiation Factor 4A-II 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • BM-010 3
  • EIF4A 3

External Ids for EIF4A2 Gene

Previous HGNC Symbols for EIF4A2 Gene

  • EIF4F

Previous GeneCards Identifiers for EIF4A2 Gene

  • GC03P183276
  • GC03P187758
  • GC03P187903
  • GC03P187822
  • GC03P187984
  • GC03P186503
  • GC03P186522
  • GC03P186528
  • GC03P186533
  • GC03P186539
  • GC03P186548
  • GC03P186556
  • GC03P186574

Summaries for EIF4A2 Gene

GeneCards Summary for EIF4A2 Gene

EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and p70S6K Signaling. GO annotations related to this gene include ATP-dependent helicase activity and helicase activity. An important paralog of this gene is EIF4A3.

UniProtKB/Swiss-Prot for EIF4A2 Gene

  • ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon

Gene Wiki entry for EIF4A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4A2 Gene

Genomics for EIF4A2 Gene

Regulatory Elements for EIF4A2 Gene

Genomic Location for EIF4A2 Gene

Start:
186,783,205 bp from pter
End:
186,789,900 bp from pter
Size:
6,696 bases
Orientation:
Plus strand

Genomic View for EIF4A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4A2 Gene

Proteins for EIF4A2 Gene

  • Protein details for EIF4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14240-IF4A2_HUMAN
    Recommended name:
    Eukaryotic initiation factor 4A-II
    Protein Accession:
    Q14240
    Secondary Accessions:
    • D3DNU9
    • Q53XJ6
    • Q96B90
    • Q96EA8

    Protein attributes for EIF4A2 Gene

    Size:
    407 amino acids
    Molecular mass:
    46402 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs.

    Three dimensional structures from OCA and Proteopedia for EIF4A2 Gene

    Alternative splice isoforms for EIF4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4A2 Gene

Proteomics data for EIF4A2 Gene at MOPED

Post-translational modifications for EIF4A2 Gene

  • Ubiquitination at Lys55, Lys285, Lys292, Lys310, and Lys370
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF4A2 Gene

Domains for EIF4A2 Gene

Gene Families for EIF4A2 Gene

HGNC:
  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for EIF4A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14240

UniProtKB/Swiss-Prot:

IF4A2_HUMAN :
  • Q14240
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
genes like me logo Genes that share domains with EIF4A2: view

Function for EIF4A2 Gene

Molecular function for EIF4A2 Gene

GENATLAS Biochemistry: eukaryotic,cap structure,translation initiation factor EIF4A,isoform 2,involved in the binding of mRNA to ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon

Enzyme Numbers (IUBMB) for EIF4A2 Gene

Gene Ontology (GO) - Molecular Function for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003743 translation initiation factor activity IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity TAS 8521730
genes like me logo Genes that share ontologies with EIF4A2: view

Phenotypes for EIF4A2 Gene

genes like me logo Genes that share phenotypes with EIF4A2: view

miRNA for EIF4A2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF4A2 Gene

Localization for EIF4A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4A2 Gene COMPARTMENTS Subcellular localization image for EIF4A2 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA --
GO:0005829 cytosol TAS --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 8521730
GO:0048471 perinuclear region of cytoplasm IDA 11922617
genes like me logo Genes that share ontologies with EIF4A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4A2 Gene

Pathways for EIF4A2 Gene

genes like me logo Genes that share pathways with EIF4A2: view

Pathways by source for EIF4A2 Gene

Gene Ontology (GO) - Biological Process for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with EIF4A2: view

Compounds for EIF4A2 Gene

(1) Novoseek inferred chemical compound relationships for EIF4A2 Gene

Compound -log(P) Hits PubMed IDs
atp 42.9 9
genes like me logo Genes that share compounds with EIF4A2: view

Transcripts for EIF4A2 Gene

mRNA/cDNA for EIF4A2 Gene

Unigene Clusters for EIF4A2 Gene

Eukaryotic translation initiation factor 4A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - - - - - - -
SP16: - - - -
SP17: - - - - -
SP18: - -
SP19:
SP20:
SP21: - - -
SP22: - - - -
SP23: - -
SP24:
SP25:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - -
SP19: - -
SP20: - -
SP21:
SP22:
SP23:
SP24:
SP25: - -

Relevant External Links for EIF4A2 Gene

GeneLoc Exon Structure for
EIF4A2
ECgene alternative splicing isoforms for
EIF4A2

Expression for EIF4A2 Gene

mRNA expression in normal human tissues for EIF4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4A2 Gene

SOURCE GeneReport for Unigene cluster for EIF4A2 Gene Hs.518475

genes like me logo Genes that share expressions with EIF4A2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4A2 Gene

Orthologs for EIF4A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4A2 35
  • 99.92 (n)
  • 100 (a)
EIF4A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4A2 35
  • 96.31 (n)
  • 100 (a)
EIF4A2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4A2 35
  • 96.89 (n)
  • 100 (a)
EIF4A2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4a2 35
  • 94.27 (n)
  • 100 (a)
Eif4a2 16
Eif4a2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF4A2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Eif4a2 35
  • 94.43 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves EIF4A2 35
  • 88.37 (n)
  • 97.79 (a)
EIF4A2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4A2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2528 35
zebrafish
(Danio rerio)
Actinopterygii eif4a2 36
  • 96 (a)
OneToOne
wufd50g11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009863 35
  • 65.08 (n)
  • 74.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF-4a 35
  • 66.92 (n)
  • 74.05 (a)
eIF-4a 36
  • 73 (a)
OneToMany
eIF-4a 37
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea F57B9.3 36
  • 52 (a)
ManyToMany
inf-1 35
  • 64.01 (n)
  • 72.24 (a)
inf-1 36
  • 70 (a)
ManyToMany
inf-1 37
  • 71 (a)
F57B9.3 37
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAL1 36
  • 57 (a)
OneToMany
TIF2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF4A-2 35
  • 68.68 (n)
  • 73.23 (a)
corn
(Zea mays)
Liliopsida Zm.437 35
rice
(Oryza sativa)
Liliopsida Os06g0701100 35
  • 68.07 (n)
  • 74.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1890 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10997 36
  • 80 (a)
OneToMany
Species with no ortholog for EIF4A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4A2 Gene

ENSEMBL:
Gene Tree for EIF4A2 (if available)
TreeFam:
Gene Tree for EIF4A2 (if available)

Paralogs for EIF4A2 Gene

Paralogs for EIF4A2 Gene

genes like me logo Genes that share paralogs with EIF4A2: view

Variants for EIF4A2 Gene

Sequence variations from dbSNP and Humsavar for EIF4A2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs266715 -- 186,782,078(+) TTTTT(C/T)GATTT upstream-variant-2KB
rs3917144 -- 186,789,084(-) CATAA(C/T)GTATA intron-variant
rs4087866 -- 186,782,087(+) AAAAA(A/T)ACTAA upstream-variant-2KB
rs16861150 -- 186,782,757(+) AATTC(A/C/G)TGCGT upstream-variant-2KB
rs34652223 -- 186,789,273(+) AATTC(C/T)TGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF4A2 Gene

Variant ID Type Subtype PubMed ID
dgv1541e1 CNV Complex 17122850
esv34136 CNV Loss 18971310
nsv10365 CNV Loss 18304495
nsv526938 CNV Gain 19592680

Relevant External Links for EIF4A2 Gene

HapMap Linkage Disequilibrium report
EIF4A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4A2 Gene

Disorders for EIF4A2 Gene

No disorders were found for EIF4A2 Gene.

No data available for UniProtKB/Swiss-Prot for EIF4A2 Gene

Publications for EIF4A2 Gene

  1. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. (PMID: 8521730) Sudo K. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. (PMID: 11408474) Li W. … Proud C.G. (J. Biol. Chem. 2001) 3 4
  4. Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. (PMID: 11922617) Kyono K. … Taguchi I. (Biochem. Biophys. Res. Commun. 2002) 3 23
  5. mRNA decay during herpes simplex virus (HSV) infections: protein- protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. (PMID: 16014927) Feng P. … Read G.S. (J. Virol. 2005) 3 4

Products for EIF4A2 Gene

Sources for EIF4A2 Gene

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