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EIF4A2 Gene

protein-coding   GIFtS: 66
GCID: GC03P186574

Eukaryotic Translation Initiation Factor 4A2

(Previous names: eukaryotic translation initiation factor 4A, isoform 2)
(Previous symbol: EIF4F)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 4A21 2     BM-0102
EIF4F1 2 3     EIF4A2
DDX2B2 3     Eukaryotic Initiation Factor 4A-II2
ATP-Dependent RNA Helicase EIF4A-22 3     Eukaryotic Translation Initiation Factor 4A2
eIF-4A-II2 3     EC 3.6.4.133
eIF4A-II2 3     EC 3.6.18
Eukaryotic Translation Initiation Factor 4A, Isoform 21     

External Ids:    HGNC: 32841   Entrez Gene: 19742   Ensembl: ENSG000001569767   OMIM: 6011025   UniProtKB: Q142403   

Export aliases for EIF4A2 gene to outside databases

Previous GC identifers: GC03P183276 GC03P187758 GC03P187903 GC03P187822 GC03P187984 GC03P186503 GC03P186522 GC03P186528 GC03P186533 GC03P186539 GC03P186548 GC03P186556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF4A2 Gene:
EIF4A2 (eukaryotic translation initiation factor 4A2) is a protein-coding gene. Diseases associated with EIF4A2 include diffuse large b-cell lymphoma, and b-cell lymphomas. GO annotations related to this gene include helicase activity and ATP-dependent helicase activity. An important paralog of this gene is EIF4A1.

UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240
Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is
required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA
secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal
subunit, and subsequent scanning for the initiator codon

Gene Wiki entry for EIF4A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF4A2 gene promoter:
         Elk-1   SREBP-1c   Lmo2   STAT5A   Meis-1b   SREBP-1b   Evi-1   E2F   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF4A2 promoter sequence
   Search Chromatin IP Primers for EIF4A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF4A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q28

EIF4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4A2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186574:  view genomic region     (about GC identifiers)

Start:
186,500,994 bp from pter      End:
186,507,689 bp from pter
Size:
6,696 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240 (See protein sequence)
Recommended Name: Eukaryotic initiation factor 4A-II  
Size: 407 amino acids; 46402 Da
Subunit: eIF4F is a multi-subunit complex, the composition of which varies with external and internal
environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts
with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs
1 PDB 3D structure from and Proteopedia for EIF4A2:
3BOR (3D)    
Secondary accessions: D3DNU9 Q53XJ6 Q96B90 Q96EA8
Alternative splicing: 2 isoforms:  Q14240-1   Q14240-2   

Explore the universe of human proteins at neXtProt for EIF4A2: NX_Q14240

Explore proteomics data for EIF4A2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys55, Lys285, Lys292, Lys310, Lys370
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EIF4A2 (Q14240) (see all 43)
     VTEEDKR  LAPTREL  ELTLEGI  HACIGGT 


    See EIF4A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001958.2  
    ENSEMBL proteins: 
     ENSP00000407504   ENSP00000415878   ENSP00000326381   ENSP00000392686   ENSP00000388237  
     ENSP00000413529   ENSP00000398370   ENSP00000402313   ENSP00000462571   ENSP00000348925  
    Reactome Protein details: Q14240

    EIF4A2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q14240

    ProtoNet protein and cluster: Q14240

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240
    Similarity: Belongs to the DEAD box helicase family. eIF4A subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    EIF4A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF4A2_HUMAN, Q14240
    Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is
    required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA
    secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal
    subunit, and subsequent scanning for the initiator codon
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for EIF4A2:
    eukaryotic,cap structure,translation initiation factor EIF4A,isoform 2,involved in the binding of mRNA to
    ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003743translation initiation factor activity IEA--
    GO:0004386helicase activity TAS8521730
    GO:0005524ATP binding IEA--
         
    EIF4A2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for EIF4A2:
     Increased S DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

         1 MGI phenotypic allele for Eif4a2 (no phenotypes)

    EIF4A2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF4A2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF4A2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF4A2

    miRNA
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    miRTarBase miRNAs that target EIF4A2:
    hsa-mir-744-5p (MIRT037614), hsa-let-7b-5p (MIRT032347), hsa-mir-331-3p (MIRT043428), hsa-mir-21-5p (MIRT005772)

    Block miRNA regulation of human, mouse, rat EIF4A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF4A2 (see all 28):
    hsa-miR-607 hsa-miR-181c hsa-miR-3146 hsa-miR-4263 hsa-miR-132 hsa-miR-105 hsa-miR-583 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidEIF4A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EIF4A2
    Predesigned siRNA for gene silencing in human, mouse, rat EIF4A2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for EIF4A2

    Clone
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    GenScript: all cDNA clones in your preferred vector: EIF4A2 (NM_001967)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF4A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016281eukaryotic translation initiation factor 4F complex TAS8521730

    EIF4A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF4A2 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    Cap-dependent Translation Initiation0.89
    2Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    Ribosomal scanning and start codon recognition0.91
    4Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF4F0.44
    5Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF4A2
        eIF2 Pathway
    mTOR Pathway
    Regulation of eIF4 and p70S6K
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF4A2
        Translational Control

    3 GeneGo (Thomson Reuters) Pathways for EIF4A2
        Translation Insulin regulation of translation
    Translation Regulation of EIF4F activity
    Translation Translation regulation by Alpha-1 adrenergic receptors

    1 BioSystems Pathway for EIF4A2
        Translation Factors

    Selected Reactome Pathways for EIF4A2 (see all 7)
        Deadenylation of mRNA
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S


    1 Kegg Pathway  (Kegg details for EIF4A2):
        RNA transport


    EIF4A2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF4A2
    Interactions:

        Search GeneGlobe Interaction Network for EIF4A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF4A2 (Q142402, 3 ENSP000003263814) via UniProtKB, MINT, STRING, and/or I2D (see all 742)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4G1Q046372, 3, ENSP000003168794MINT-17061 I2D: score=4 STRING: ENSP00000316879
    ACTBP607092, 3, ENSP000003499604MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    NEK2P519552, 3MINT-8263665 I2D: score=2 
    PFDN1O609252, 3MINT-8265794 I2D: score=2 
    TK1P041832, 3MINT-8273345 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation TAS8521730

    EIF4A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF4A2 (IF4A2)

    1 Novoseek inferred chemical compound relationship for EIF4A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 42.9 18 17584618 (2), 1719376 (2), 16166382 (1), 9732867 (1) (see all 7)



    EIF4A2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EIF4A2 gene: 
    NM_001967.3  

    Unigene Clusters for EIF4A2:

    Eukaryotic translation initiation factor 4A2
    Hs.518475  [show with all ESTs], Hs.599481  [show with all ESTs]
    Unigene Representative Sequences: BC013708, BC039344
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000441007 ENST00000445596 ENST00000323963(uc003fqs.3 uc003fqu.3)
    ENST00000426808(uc003fqv.3 uc003fqw.3) ENST00000465222 ENST00000491473
    ENST00000486805 ENST00000465032 ENST00000465267 ENST00000495049 ENST00000429589
    ENST00000425053 ENST00000440191 ENST00000485101(uc011bsb.2) ENST00000475653
    ENST00000443963 ENST00000498746 ENST00000467585
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate EIF4A2 (see all 28):
    hsa-miR-607 hsa-miR-181c hsa-miR-3146 hsa-miR-4263 hsa-miR-132 hsa-miR-105 hsa-miR-583 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidEIF4A2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat EIF4A2
      QuantiFast Probe-based Assays in human, mouse, rat EIF4A2

    Additional mRNA sequence: BC039344.1 

    Selected DOTS entries (see all 102):

    DT.100704120  DT.95366981  DT.95367045  DT.100861682  DT.92471170  DT.92471144  DT.92471199  DT.91813486 
    DT.120916005  DT.120915987  DT.100704110  DT.95367030  DT.214260  DT.100704107  DT.100704115  DT.85105316 
    DT.92471183  DT.120915819  DT.100059712  DT.100704083  DT.100704094  DT.100704092  DT.120915891  DT.120915972 

    16 AceView cDNA sequences:

    N79339 AA496083 AI969861 BG722642 BG721373 BC039344 BX118227 CD171717 
    BF979955 AI090838 N62248 BI463735 AA406081 CD300445 BI831749 BF979570 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A2 (see all 25)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
    SP1:                          -     -           -           -     -           -     -                                   -     -                       -         
    SP2:                          -     -           -           -     -           -     -                                   -     -                       -         
    SP3:                          -     -           -           -     -     -     -     -                                   -     -                       -         
    SP4:                          -     -                 -     -     -     -     -     -                                   -     -                       -         
    SP5:                          -     -           -           -     -     -     -     -                                   -     -                       -         

    ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:  -           -     -                                 
    SP2:  -           -     -                                 
    SP3:                                                      
    SP4:  -                                                   
    SP5:                                                      


    ECgene alternative splicing isoforms for EIF4A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF4A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCGAAAAA
    EIF4A2 Expression
    About this image


    EIF4A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    EIF4A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF4A2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.518475 Hs.599481
        Custom PCR Arrays for EIF4A2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF4A2 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif4a21 , 5 eukaryotic translation initiation factor 4A21, 5 94.27(n)1
    100(a)1
      16 (13.93 cM)5
    136821  NM_013506.21  NP_038534.21 
     231074445 
    chicken
    (Gallus gallus)
    Aves EIF4A21 eukaryotic translation initiation factor 4A2 88.37(n)
    97.79(a)
      395232  NM_204549.1  NP_989880.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF4A26
    eukaryotic translation initiation factor 4A2
    98(a)
    1 ↔ 1
    GL343321.1(111888-124050)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041252.12   -- 83.29(n)    BC041252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd50g112 Danio rerio cDNA clone MGC63783 IMAGE2643605, complete more 79.38(n)    BC055242.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF-4a1 , 3 translational initiation translation
    initiation more3
    Eukaryotic initiation factor 4a1
    73(a)3
    66.92(n)1
    74.05(a)1
      338351  NM_001258978.21  NP_001245907.11 
    worm
    (Caenorhabditis elegans)
    Secernentea inf-11 , 3 inf-11 71(a)
    (best of 2)3
    64.01(n)1
    72.24(a)1
      III(7001893-7003341)3
    1759661  NM_001027452.21  NP_001022623.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF2(YJL138C)4 Translation initiation factor eIF4A, identical to Tif1p; more   --   10(154691-153504) 853303  NP_012397.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF4A-21 EIF4A-2 68.68(n)
    73.23(a)
      841868  NM_104305.3  NP_175829.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g07011001 Os06g0701100 68.07(n)
    74.54(a)
      4341966  NM_001065016.1  NP_001058481.1 


    ENSEMBL Gene Tree for EIF4A2 (if available)
    TreeFam Gene Tree for EIF4A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF4A2 gene
    EIF4A12  EIF4A32  
    Selected SIMAP similar genes for EIF4A2 using alignment to 8 protein entries:     IF4A2_HUMAN (see all proteins) (see all similar genes):
    EIF4A1    DKFZp566L241    EIF4A3    DKFZp547B159    DDX25    BAT1
    DDX6    DDX39B    DDX19A    DDX39A    DDX19B    DKFZp762C1313
    DDX19L    DDX20    DDX43    DKFZp686C21137    DDX59    DDX53

    EIF4A2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for EIF4A2 (see all 6)
    PGOHUM00000238838 PGOHUM00000238839 PGOHUM00000242296 PGOHUM00000242631 PGOHUM00000262941


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF4A2 (see all 64)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358384
    A breast cancer sample4--see VAR_0358382 V L mis40--------
    rs1482317751,2
    --186499469(+) GCACGC/TTCTGT 1 -- us2k10--------
    rs1401846041,2
    C--186499513(+) TTGATA/CTTTAA 1 -- us2k10--------
    rs1161019341,2
    C,F--186499578(+) GTAATC/TACTGC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1503584701,2
    C--186499649(+) GAAGTG/TTTCTT 1 -- us2k10--------
    rs1843586301,2
    --186499671(+) TACTTA/GGCACT 1 -- us2k10--------
    rs1147276141,2
    C,F--186499699(+) GAGTTT/AAGCCT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1165972311,2
    C,F--186499702(+) TTTAGC/GCTTTA 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1881049571,2
    --186499745(+) ATCTAA/GTGTAG 1 -- us2k10--------
    rs762247891,2
    C--186499778(+) CAACGA/CTTAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EIF4A2 (186500994 - 186507689 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for EIF4A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34136CNV Loss18971310
    nsv10365CNV Loss18304495
    nsv526938CNV Gain19592680
    dgv1541e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF4A2
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF4A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601102    OMIM disorders: --

    16 diseases for EIF4A2:    
    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas    cholera    herpes simplex
    acute myeloid leukemia    hepatitis c virus    breast and colorectal cancer    myeloid leukemia
    hepatitis c    schizophrenia    leukemia    neuroblastoma
    hepatitis    hiv-1    colorectal cancer    malaria


    EIF4A2 for disorders           About GeneDecksing


    Export disorders for EIF4A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF4A2 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with EIF4A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. (PubMed id 8521730)1, 2, 3 Sudo K.... Nakamura Y. (Cytogenet. Cell Genet. 1995)
    2. mRNA decay during herpes simplex virus (HSV) infections: protein- protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. (PubMed id 16014927)1, 2 Feng P.... Read G.S. (J. Virol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. (PubMed id 11408474)1, 2 Li W.... Proud C.G. (J. Biol. Chem. 2001)
    5. Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. (PubMed id 11922617)1, 9 Kyono K....Taguchi I. (Biochem. Biophys. Res. Commun. 2002)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    7. Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation. (PubMed id 23559250)1 Meijer H.A....Bushell M. (Science 2013)
    8. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1974 HGNC: 3284 AceView: EIF4A2.1 Ensembl:ENSG00000156976 euGenes: HUgn1974
    ECgene: EIF4A2 Kegg: 1974 H-InvDB: EIF4A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF4A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF4A2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF4A2 gene:
    Search GeneIP for patents involving EIF4A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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