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Aliases for EIF4A2 Gene

Aliases for EIF4A2 Gene

  • Eukaryotic Translation Initiation Factor 4A2 2 3 5
  • ATP-Dependent RNA Helicase EIF4A-2 3 4
  • EIF-4A-II 3 4
  • EIF4A-II 3 4
  • EIF4F 3 4
  • DDX2B 3 4
  • Eukaryotic Translation Initiation Factor 4A, Isoform 2 2
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • BM-010 3
  • EIF4A 3

External Ids for EIF4A2 Gene

Previous HGNC Symbols for EIF4A2 Gene

  • EIF4F

Previous GeneCards Identifiers for EIF4A2 Gene

  • GC03P183276
  • GC03P187758
  • GC03P187903
  • GC03P187822
  • GC03P187984
  • GC03P186503
  • GC03P186522
  • GC03P186528
  • GC03P186533
  • GC03P186539
  • GC03P186548
  • GC03P186556
  • GC03P186574

Summaries for EIF4A2 Gene

GeneCards Summary for EIF4A2 Gene

EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Among its related pathways are Gene Expression and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A3.

UniProtKB/Swiss-Prot for EIF4A2 Gene

  • ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Gene Wiki entry for EIF4A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4A2 Gene

Genomics for EIF4A2 Gene

Regulatory Elements for EIF4A2 Gene

Enhancers for EIF4A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF4A2 on UCSC Golden Path with GeneCards custom track

Promoters for EIF4A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF4A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF4A2 Gene

Chromosome:
3
Start:
186,783,205 bp from pter
End:
186,789,900 bp from pter
Size:
6,696 bases
Orientation:
Plus strand

Genomic View for EIF4A2 Gene

Genes around EIF4A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4A2 Gene

Proteins for EIF4A2 Gene

  • Protein details for EIF4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14240-IF4A2_HUMAN
    Recommended name:
    Eukaryotic initiation factor 4A-II
    Protein Accession:
    Q14240
    Secondary Accessions:
    • D3DNU9
    • Q53XJ6
    • Q96B90
    • Q96EA8

    Protein attributes for EIF4A2 Gene

    Size:
    407 amino acids
    Molecular mass:
    46402 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs.

    Three dimensional structures from OCA and Proteopedia for EIF4A2 Gene

    Alternative splice isoforms for EIF4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4A2 Gene

Proteomics data for EIF4A2 Gene at MOPED

Post-translational modifications for EIF4A2 Gene

  • Ubiquitination at Lys 310 and Lys 370
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF4A2 (EIF4A2)

Domains & Families for EIF4A2 Gene

Gene Families for EIF4A2 Gene

Suggested Antigen Peptide Sequences for EIF4A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14240

UniProtKB/Swiss-Prot:

IF4A2_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
genes like me logo Genes that share domains with EIF4A2: view

Function for EIF4A2 Gene

Molecular function for EIF4A2 Gene

GENATLAS Biochemistry:
eukaryotic,cap structure,translation initiation factor EIF4A,isoform 2,involved in the binding of mRNA to ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Enzyme Numbers (IUBMB) for EIF4A2 Gene

Gene Ontology (GO) - Molecular Function for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11922617
GO:0016887 ATPase activity IDA 11922617
genes like me logo Genes that share ontologies with EIF4A2: view
genes like me logo Genes that share phenotypes with EIF4A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EIF4A2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4A2 Gene

Localization for EIF4A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4A2 Gene COMPARTMENTS Subcellular localization image for EIF4A2 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EIF4A2 Gene

Pathways & Interactions for EIF4A2 Gene

genes like me logo Genes that share pathways with EIF4A2: view

Gene Ontology (GO) - Biological Process for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0008152 metabolic process IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with EIF4A2: view

No data available for SIGNOR curated interactions for EIF4A2 Gene

Drugs & Compounds for EIF4A2 Gene

(2) Drugs for EIF4A2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for EIF4A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with EIF4A2: view

Transcripts for EIF4A2 Gene

mRNA/cDNA for EIF4A2 Gene

Unigene Clusters for EIF4A2 Gene

Eukaryotic translation initiation factor 4A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - - - - - - -
SP16: - - - -
SP17: - - - - -
SP18: - -
SP19:
SP20:
SP21: - - -
SP22: - - - -
SP23: - -
SP24:
SP25:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - -
SP19: - -
SP20: - -
SP21:
SP22:
SP23:
SP24:
SP25: - -

Relevant External Links for EIF4A2 Gene

GeneLoc Exon Structure for
EIF4A2
ECgene alternative splicing isoforms for
EIF4A2

Expression for EIF4A2 Gene

mRNA expression in normal human tissues for EIF4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4A2 Gene



SOURCE GeneReport for Unigene cluster for EIF4A2 Gene Hs.518475

genes like me logo Genes that share expression patterns with EIF4A2: view

Protein tissue co-expression partners for EIF4A2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4A2 Gene

Orthologs for EIF4A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4A2 35
  • 96.31 (n)
  • 100 (a)
EIF4A2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4A2 35
  • 96.89 (n)
  • 100 (a)
EIF4A2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4a2 35
  • 94.27 (n)
  • 100 (a)
Eif4a2 16
Eif4a2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4A2 35
  • 99.92 (n)
  • 100 (a)
EIF4A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4a2 35
  • 94.43 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF4A2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
ManyToMany
chicken
(Gallus gallus)
Aves EIF4A2 35
  • 88.37 (n)
  • 97.79 (a)
EIF4A2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4A2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2528 35
zebrafish
(Danio rerio)
Actinopterygii wufd50g11 35
eif4a2 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta eIF-4a 37
  • 73 (a)
eIF-4a 35
  • 66.92 (n)
  • 74.05 (a)
eIF-4a 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009863 35
  • 65.08 (n)
  • 74.75 (a)
worm
(Caenorhabditis elegans)
Secernentea F57B9.3 37
  • 51 (a)
inf-1 37
  • 71 (a)
inf-1 35
  • 64.01 (n)
  • 72.24 (a)
F57B9.3 36
  • 52 (a)
ManyToMany
inf-1 36
  • 70 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAL1 36
  • 57 (a)
OneToMany
TIF2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF4A-2 35
  • 68.68 (n)
  • 73.23 (a)
rice
(Oryza sativa)
Liliopsida Os06g0701100 35
  • 68.07 (n)
  • 74.54 (a)
corn
(Zea mays)
Liliopsida Zm.437 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1890 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10997 36
  • 80 (a)
OneToMany
Species with no ortholog for EIF4A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4A2 Gene

ENSEMBL:
Gene Tree for EIF4A2 (if available)
TreeFam:
Gene Tree for EIF4A2 (if available)

Paralogs for EIF4A2 Gene

Paralogs for EIF4A2 Gene

genes like me logo Genes that share paralogs with EIF4A2: view

Variants for EIF4A2 Gene

Sequence variations from dbSNP and Humsavar for EIF4A2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035838 A breast cancer sample
VAR_052158 -
rs266715 -- 186,782,078(+) TTTTT(C/T)GATTT upstream-variant-2KB
rs16861150 -- 186,782,757(+) AATTC(A/C/G)TGCGT upstream-variant-2KB
rs34652223 -- 186,789,273(+) AATTC(C/T)TGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF4A2 Gene

Variant ID Type Subtype PubMed ID
dgv1541e1 CNV Complex 17122850
esv34136 CNV Loss 18971310
nsv10365 CNV Loss 18304495
nsv526938 CNV Gain 19592680

Variation tolerance for EIF4A2 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EIF4A2 Gene

Disorders for EIF4A2 Gene

Relevant External Links for EIF4A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4A2

No disorders were found for EIF4A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4A2 Gene

Publications for EIF4A2 Gene

  1. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. (PMID: 8521730) Sudo K. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4 67
  2. Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. (PMID: 11922617) Kyono K. … Taguchi I. (Biochem. Biophys. Res. Commun. 2002) 3 23
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  4. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for EIF4A2 Gene

Sources for EIF4A2 Gene

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