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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF4A2 Gene

protein-coding   GIFtS: 66
GCID: GC03P186556

Eukaryotic Translation Initiation Factor 4A2

(Previous names: eukaryotic translation initiation factor 4A, isoform 2)
(Previous symbol: EIF4F)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 4A21 2     BM-0102
EIF4F1 2 3     EIF4A2
DDX2B2 3     Eukaryotic Initiation Factor 4A-II2
ATP-Dependent RNA Helicase EIF4A-22 3     Eukaryotic Translation Initiation Factor 4A2
eIF-4A-II2 3     EC 3.6.4.133
eIF4A-II2 3     EC 3.6.18
Eukaryotic Translation Initiation Factor 4A, Isoform 21     

External Ids:    HGNC: 32841   Entrez Gene: 19742   Ensembl: ENSG000001569767   OMIM: 6011025   UniProtKB: Q142403   

Export aliases for EIF4A2 gene to outside databases

Previous GC identifers: GC03P183276 GC03P187758 GC03P187903 GC03P187822 GC03P187984 GC03P186503 GC03P186522 GC03P186528 GC03P186533 GC03P186539 GC03P186548


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EIF4A2 Gene: 
EIF4A2 (eukaryotic translation initiation factor 4A2) is a protein-coding gene. Diseases associated with EIF4A2 include diffuse large b-cell lymphoma, and cholera, and among its related super-pathways are Eukaryotic Translation Initiation and Interferon Signaling. GO annotations related to this gene include helicase activity and ATP-dependent helicase activity. An important paralog of this gene is EIF4A1.

UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240
Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is
required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA
secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal
subunit, and subsequent scanning for the initiator codon

Gene Wiki entry for EIF4A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF4A2 gene promoter:
         Elk-1   SREBP-1c   Lmo2   STAT5A   Meis-1b   SREBP-1b   Evi-1   E2F   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF4A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF4A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF4A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q28

EIF4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF4A2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186556:  view genomic region     (about GC identifiers)

Start:
186,500,994 bp from pter      End:
186,507,689 bp from pter
Size:
6,696 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240 (See protein sequence)
Recommended Name: Eukaryotic initiation factor 4A-II  
Size: 407 amino acids; 46402 Da
Subunit: eIF4F is a multi-subunit complex, the composition of which varies with external and internal
environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts
with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs
1 PDB 3D structure from and Proteopedia for EIF4A2:
3BOR (3D)    
Secondary accessions: D3DNU9 Q53XJ6 Q96B90 Q96EA8
Alternative splicing: 2 isoforms:  Q14240-1   Q14240-2   

Explore the universe of human proteins at neXtProt for EIF4A2: NX_Q14240

Explore proteomics data for EIF4A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14240

  • 4/43 DME Specific Peptides for EIF4A2 (Q14240) (see all 43)
     VTEEDKR  LAPTREL  ELTLEGI  HACIGGT 

    EIF4A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF4A2 Protein Expression
    REFSEQ proteins: NP_001958.2  
    ENSEMBL proteins: 
     ENSP00000407504   ENSP00000415878   ENSP00000326381   ENSP00000392686   ENSP00000388237  
     ENSP00000413529   ENSP00000398370   ENSP00000402313   ENSP00000462571   ENSP00000348925  
    Reactome Protein details: Q14240
    Human Recombinant Protein Products for EIF4A2: 
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    Cloud-Clone Corp. Proteins for EIF4A2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016281eukaryotic translation initiation factor 4F complex TAS8521730

    EIF4A2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DDX: DEAD-boxes

    5/6 InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q14240

    ProtoNet protein and cluster: Q14240

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: IF4A2_HUMAN, Q14240
    Similarity: Belongs to the DEAD box helicase family. eIF4A subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    EIF4A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF4A2_HUMAN, Q14240
    Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is
    required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA
    secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal
    subunit, and subsequent scanning for the initiator codon
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for EIF4A2:
    eukaryotic,cap structure,translation initiation factor EIF4A,isoform 2,involved in the binding of mRNA to
    ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003743translation initiation factor activity IEA--
    GO:0004386helicase activity TAS8521730
    GO:0005515protein binding ----
         
    EIF4A2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for EIF4A2:
     Increased S DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

         1 MGI phenotypic allele for Eif4a2 (no phenotypes)

    EIF4A2 for phenotypes           About GeneDecksing

    Animal Models:
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF4A2 (see all 28):
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    SwitchGear 3'UTR luciferase reporter plasmidEIF4A2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF4A2 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit0.94
    3' -UTR-mediated translational regulation0.93
    Eukaryotic Translation Initiation0.94
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Cap-dependent Translation Initiation0.94
    Translation0.78
    2Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    3Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Translation initiation complex formation0.87
    Ribosomal scanning and start codon recognition0.95
    4Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    5Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF4F0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for EIF4A2
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Translation Insulin regulation of translation
    Translation Regulation activity of EIF4F

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF4A2
        eIF2 Pathway
    mTOR Pathway
    Regulation of eIF4 and p70S6K
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF4A2
        Translational Control

    3 GeneGo (Thomson Reuters) Pathways for EIF4A2
        Translation Insulin regulation of translation
    Translation Regulation of EIF4F activity
    Translation Translation regulation by Alpha-1 adrenergic receptors

    1 BioSystems Pathway for EIF4A2
        Translation Factors

    5/20        Reactome Pathways for EIF4A2 (see all 20)
        Antiviral mechanism by IFN-stimulated genes
    Translation
    Eukaryotic Translation Initiation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    L13a-mediated translational silencing of Ceruloplasmin expression


    1         Kegg Pathway  (Kegg details for EIF4A2):
        RNA transport


    EIF4A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF4A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/623 Interacting proteins for EIF4A2 (Q142401, 2, 3 ENSP000003263814) via UniProtKB, MINT, STRING, and/or I2D (see all 623)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4G1Q046371, 2, 3, ENSP000003168794EBI-73473,EBI-73711 MINT-17061 I2D: score=4 STRING: ENSP00000316879
    ACTBP607092, 3, ENSP000003499604MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    NEK2P519552, 3MINT-8263665 I2D: score=2 
    PFDN1O609252, 3MINT-8265794 I2D: score=2 
    TK1P041832, 3MINT-8273345 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation TAS8521730

    EIF4A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EIF4A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF4A2 (IF4A2)

    1 Novoseek inferred chemical compound relationship for EIF4A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 42.9 18 17584618 (2), 1719376 (2), 16166382 (1), 9732867 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about EIF4A2 / IF4A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF4A2 gene: 
    NM_001967.3  

    Unigene Clusters for EIF4A2:

    Eukaryotic translation initiation factor 4A2
    Hs.518475  [show with all ESTs], Hs.599481  [show with all ESTs]
    Unigene Representative Sequences: BC013708, BC039344
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000441007 ENST00000445596 ENST00000323963(uc003fqs.3 uc003fqu.3)
    ENST00000426808(uc003fqv.3 uc003fqw.3) ENST00000465222 ENST00000491473
    ENST00000486805 ENST00000465032 ENST00000465267 ENST00000495049 ENST00000429589
    ENST00000425053 ENST00000440191 ENST00000485101(uc011bsb.2) ENST00000475653
    ENST00000443963 ENST00000498746 ENST00000467585
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: BC039344.1 

    24/102 DOTS entries (see all 102):

    DT.100704120  DT.95366981  DT.95367045  DT.100861682  DT.92471170  DT.92471144  DT.92471199  DT.91813486 
    DT.120916005  DT.120915987  DT.100704110  DT.95367030  DT.214260  DT.100704107  DT.100704115  DT.85105316 
    DT.92471183  DT.120915819  DT.100059712  DT.100704083  DT.100704094  DT.100704092  DT.120915891  DT.120915972 

    16 AceView cDNA sequences:

    N79339 BG722642 BC039344 BF979955 BG721373 CD171717 AI090838 BX118227 
    AA496083 N62248 AI969861 CD300445 BI463735 BI831749 AA406081 BF979570 

    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A2 (see all 25)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
    SP1:                          -     -           -           -     -           -     -                                   -     -                       -         
    SP2:                          -     -           -           -     -           -     -                                   -     -                       -         
    SP3:                          -     -           -           -     -     -     -     -                                   -     -                       -         
    SP4:                          -     -                 -     -     -     -     -     -                                   -     -                       -         
    SP5:                          -     -           -           -     -     -     -     -                                   -     -                       -         

    ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:  -           -     -                                 
    SP2:  -           -     -                                 
    SP3:                                                      
    SP4:  -                                                   
    SP5:                                                      


    ECgene alternative splicing isoforms for EIF4A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF4A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCGAAAAA
    EIF4A2 Expression
    About this image


    See EIF4A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF4A2

    SOURCE GeneReport for Unigene clusters: Hs.518475 Hs.599481
        SABiosciences Custom PCR Arrays for EIF4A2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF4A2 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif4a21 , 5 eukaryotic translation initiation factor 4A21, 5 94.27(n)1
    100(a)1
      16 (13.93 cM)5
    136821  NM_013506.21  NP_038534.21 
     231074445 
    chicken
    (Gallus gallus)
    Aves EIF4A21 eukaryotic translation initiation factor 4A2 88.37(n)
    97.79(a)
      395232  NM_204549.1  NP_989880.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF4A26
    Uncharacterized protein
    98(a)
    1 ↔ 1
    GL343321.1(111888-124050)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041252.12   -- 83.29(n)    BC041252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd50g112 Danio rerio cDNA clone MGC63783 IMAGE2643605, complete more 79.38(n)    BC055242.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF-4a1 , 3 translational initiation translation
    initiation more3
    Eukaryotic initiation factor 4a1
    73(a)3
    66.92(n)1
    74.05(a)1
      338351  NM_057247.41  NP_476595.11 
    worm
    (Caenorhabditis elegans)
    Secernentea inf-11 , 3 Protein INF-11 71(a)
    (best of 2)3
    64.01(n)1
    72.24(a)1
      III(7001893-7003341)3
    1759661  NM_001027452.11  NP_001022623.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF2(YJL138C)4 Translation initiation factor eIF4A, identical to Tif1p; more   --   10(154691-153504) 853303  NP_012397.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF4A11 translational initiation factor 4A-1 67.45(n)
    72.97(a)
      820605  NM_112246.3  NP_566469.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g07011001 hypothetical protein 68.15(n)
    74.28(a)
      4341966  NM_001065016.1  NP_001058481.1 


    ENSEMBL Gene Tree for EIF4A2 (if available)
    TreeFam Gene Tree for EIF4A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF4A2 gene
    EIF4A12  EIF4A32  
    18/41 SIMAP similar genes for EIF4A2 using alignment to 8 protein entries:     IF4A2_HUMAN (see all proteins) (see all similar genes):
    EIF4A1    DKFZp566L241    EIF4A3    DKFZp547B159    DDX25    BAT1
    DDX6    DDX39B    DDX19A    DDX39A    DDX19B    DKFZp762C1313
    DDX19L    DDX20    DDX43    DKFZp686C21137    DDX59    DDX53

    EIF4A2 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for EIF4A2 (see all 6)
    PGOHUM00000238838 PGOHUM00000238839 PGOHUM00000242296 PGOHUM00000242631 PGOHUM00000262941


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/64 SNPs in EIF4A2 are shown (see all 64)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358384
    A breast cancer sample4--see VAR_0358382 V L mis40--------
    VAR_0521584
    ----see VAR_0521582 Q H mis40--------
    rs1482317751,2
    --186499469(+) GCACGC/TTCTGT 1 -- us2k10--------
    rs1401846041,2
    C--186499513(+) TTGATA/CTTTAA 1 -- us2k10--------
    rs1161019341,2
    C,F--186499578(+) GTAATC/TACTGC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1503584701,2
    C--186499649(+) GAAGTG/TTTCTT 1 -- us2k10--------
    rs1843586301,2
    --186499671(+) TACTTA/GGCACT 1 -- us2k10--------
    rs1147276141,2
    C,F--186499699(+) GAGTTT/AAGCCT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1165972311,2
    C,F--186499702(+) TTTAGC/GCTTTA 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1881049571,2
    --186499745(+) ATCTAA/GTGTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EIF4A2 (186500994 - 186507689 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for EIF4A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34136CNV Loss18971310
    nsv10365CNV Loss18304495
    nsv526938CNV Gain19592680
    dgv1541e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601102    OMIM disorders: --

    10 diseases for EIF4A2:    About MalaCards
    diffuse large b-cell lymphoma    cholera    b-cell lymphomas    herpes simplex
    acute myeloid leukemia    myeloid leukemia    hepatitis c    schizophrenia
    hepatitis    leukemia


    EIF4A2 for disorders           About GeneDecksing


    Export disorders for EIF4A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF4A2 gene, integrated from 9 sources (see all 92):
    (articles sorted by number of sources associating them with EIF4A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. (PubMed id 8521730)1, 2, 3 Sudo K.... Nakamura Y. (1995)
    2. mRNA decay during herpes simplex virus (HSV) infections: protein- protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. (PubMed id 16014927)1, 2 Feng P.... Read G.S. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. (PubMed id 11408474)1, 2 Li W.... Proud C.G. (2001)
    5. Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. (PubMed id 11922617)1, 9 Kyono K....Taguchi I. (2002)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    7. Translational repression and eIF4A2 activity are criti cal for microRNA-mediated gene regulation. (PubMed id 23559250)1 Meijer H.A....Bushell M. (2013)
    8. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1974 HGNC: 3284 AceView: EIF4A2.1 Ensembl:ENSG00000156976 euGenes: HUgn1974
    ECgene: EIF4A2 Kegg: 1974 H-InvDB: EIF4A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF4A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF4A2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EIF4A2 gene:
    Search GeneIP for patents involving EIF4A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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