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Aliases for EIF4A1 Gene

Aliases for EIF4A1 Gene

  • Eukaryotic Translation Initiation Factor 4A1 2 3 5
  • ATP-Dependent RNA Helicase EIF4A-1 3 4
  • EIF-4A-I 3 4
  • EIF4A-I 3 4
  • EIF4A 3 4
  • DDX2A 3 4
  • Eukaryotic Translation Initiation Factor 4A, Isoform 1 2
  • Eukaryotic Translation Initiation Factor 4A 3
  • Eukaryotic Initiation Factor 4AI 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • EIF-4A 3

External Ids for EIF4A1 Gene

Previous HGNC Symbols for EIF4A1 Gene

  • EIF4A

Previous GeneCards Identifiers for EIF4A1 Gene

  • GC17P007880
  • GC17P008215
  • GC17P007418
  • GC17P007676
  • GC17P007416
  • GC17P007404
  • GC17P007476

Summaries for EIF4A1 Gene

GeneCards Summary for EIF4A1 Gene

EIF4A1 (Eukaryotic Translation Initiation Factor 4A1) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A2.

UniProtKB/Swiss-Prot for EIF4A1 Gene

  • ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Gene Wiki entry for EIF4A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4A1 Gene

Genomics for EIF4A1 Gene

Regulatory Elements for EIF4A1 Gene

Promoters for EIF4A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF4A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF4A1 Gene

Chromosome:
17
Start:
7,572,706 bp from pter
End:
7,579,006 bp from pter
Size:
6,301 bases
Orientation:
Plus strand

Genomic View for EIF4A1 Gene

Genes around EIF4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4A1 Gene

Proteins for EIF4A1 Gene

  • Protein details for EIF4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60842-IF4A1_HUMAN
    Recommended name:
    Eukaryotic initiation factor 4A-I
    Protein Accession:
    P60842
    Secondary Accessions:
    • B2R6L8
    • D3DTP9
    • J3QLC4
    • P04765
    • Q5U018
    • Q61516

    Protein attributes for EIF4A1 Gene

    Size:
    406 amino acids
    Molecular mass:
    46154 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4. Interacts with human cytomegalovirus/HHV-5 protein UL69.

    Three dimensional structures from OCA and Proteopedia for EIF4A1 Gene

    Alternative splice isoforms for EIF4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4A1 Gene

Proteomics data for EIF4A1 Gene at MOPED

Post-translational modifications for EIF4A1 Gene

  • Ubiquitination at Lys 174, Lys 177, Lys 237, Lys 238, Lys 309, Lys 369, and Lys 381
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF4A1 (EIF4A1)

Domains & Families for EIF4A1 Gene

Gene Families for EIF4A1 Gene

Graphical View of Domain Structure for InterPro Entry

P60842

UniProtKB/Swiss-Prot:

IF4A1_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
genes like me logo Genes that share domains with EIF4A1: view

Function for EIF4A1 Gene

Molecular function for EIF4A1 Gene

GENATLAS Biochemistry:
eukaryotic,cap structure,translocation factor EIF4A,isoform1,involved in the binding of mRNA to 40S subunit of ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family,tightly linked to CD8 in same orientation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Helicase activity and function in translation are inhibited by interaction with PDCD4.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Enzyme Numbers (IUBMB) for EIF4A1 Gene

Gene Ontology (GO) - Molecular Function for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0005515 protein binding IPI 9548260
GO:0005524 ATP binding IEA --
GO:0008135 translation factor activity, RNA binding TAS 3215517
genes like me logo Genes that share ontologies with EIF4A1: view
genes like me logo Genes that share phenotypes with EIF4A1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4A1 Gene

Localization for EIF4A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4A1 Gene COMPARTMENTS Subcellular localization image for EIF4A1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4

Gene Ontology (GO) - Cellular Components for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EIF4A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4A1 Gene

Pathways & Interactions for EIF4A1 Gene

genes like me logo Genes that share pathways with EIF4A1: view

Gene Ontology (GO) - Biological Process for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0008152 metabolic process IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0031100 organ regeneration IEA --
genes like me logo Genes that share ontologies with EIF4A1: view

No data available for SIGNOR curated interactions for EIF4A1 Gene

Drugs & Compounds for EIF4A1 Gene

(2) Drugs for EIF4A1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for EIF4A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with EIF4A1: view

Transcripts for EIF4A1 Gene

Unigene Clusters for EIF4A1 Gene

Eukaryotic translation initiation factor 4A1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - -
SP10: -
SP11: -
SP12: -
SP13: -
SP14: - -
SP15: - - - - - - - -
SP16: - - - -
SP17:

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for EIF4A1 Gene

GeneLoc Exon Structure for
EIF4A1
ECgene alternative splicing isoforms for
EIF4A1

Expression for EIF4A1 Gene

mRNA expression in normal human tissues for EIF4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4A1 Gene



SOURCE GeneReport for Unigene cluster for EIF4A1 Gene Hs.129673

genes like me logo Genes that share expression patterns with EIF4A1: view

Protein tissue co-expression partners for EIF4A1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4A1 Gene

Orthologs for EIF4A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4A1 35
  • 92.94 (n)
  • 100 (a)
EIF4A1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4A1 35
  • 92.12 (n)
  • 100 (a)
EIF4A1 36
  • 100 (a)
OneToMany
EIF4A1 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif4a1 35
  • 92.61 (n)
  • 100 (a)
Eif4a1 16
Eif4a1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4A1 35
  • 99.26 (n)
  • 99.75 (a)
EIF4A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4a1 35
  • 92.45 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF4A1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4A1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4A1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4a1 35
  • 81.03 (n)
  • 95.07 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
eif4a1a 35
  • 78.9 (n)
  • 89.66 (a)
eif4a1b 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5074 35
fruit fly
(Drosophila melanogaster)
Insecta eIF-4a 37
  • 73 (a)
eIF-4a 36
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F57B9.3 37
  • 52 (a)
inf-1 37
  • 71 (a)
F57B9.3 36
  • 52 (a)
ManyToMany
inf-1 36
  • 69 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR253C 35
  • 64.57 (n)
  • 66.75 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05731g 35
  • 62.94 (n)
  • 66.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF2 35
  • 62.25 (n)
  • 66.75 (a)
FAL1 36
  • 57 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G72730 35
  • 64.53 (n)
  • 70.77 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2781 35
rice
(Oryza sativa)
Liliopsida Os.458 35
wheat
(Triticum aestivum)
Liliopsida Ta.18 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07420 35
  • 70.51 (n)
  • 78.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1006.07 35
  • 66.23 (n)
  • 75.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10997 36
  • 80 (a)
OneToMany
Species with no ortholog for EIF4A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF4A1 Gene

ENSEMBL:
Gene Tree for EIF4A1 (if available)
TreeFam:
Gene Tree for EIF4A1 (if available)

Paralogs for EIF4A1 Gene

Paralogs for EIF4A1 Gene

genes like me logo Genes that share paralogs with EIF4A1: view

Variants for EIF4A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF4A1 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294

Variation tolerance for EIF4A1 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4A1 Gene

HapMap Linkage Disequilibrium report
EIF4A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for EIF4A1 Gene

Disorders for EIF4A1 Gene

Relevant External Links for EIF4A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4A1

No disorders were found for EIF4A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4A1 Gene

Publications for EIF4A1 Gene

  1. Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI. (PMID: 8493113) Kim N.-S. … Kato S. (Nucleic Acids Res. 1993) 2 3 4 23 67
  2. PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. (PMID: 18296639) Suzuki C. … Wagner G. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  3. Interactions between eIF4AI and its accessory factors eIF4B and eIF4H. (PMID: 18719248) Rozovsky N. … Moore M.J. (RNA 2008) 3 23
  4. Functional analysis of individual binding activities of the scaffold protein eIF4G. (PMID: 17130132) Hinton T.M. … Pain V.M. (J. Biol. Chem. 2007) 3 23
  5. Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. (PMID: 18034160) Kim W.J. … Jang S.K. (EMBO J. 2007) 3 23

Products for EIF4A1 Gene

Sources for EIF4A1 Gene

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