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Aliases for EIF3M Gene

Aliases for EIF3M Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit M 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit M 2 3
  • PCI Domain Containing 1 (Herpesvirus Entry Mediator) 2 3
  • PCI Domain-Containing Protein 1 3 4
  • Fetal Lung Protein B5 3 4
  • Hfl-B5 3 4
  • PCID1 3 4
  • Transport And Golgi Organization 7 Homolog (Drosophila) 2
  • Transport And Golgi Organization 7 Homolog 3
  • Dendritic Cell Protein 3
  • B5 Receptor 3
  • TANGO7 3
  • HFLB5 4
  • EIF3m 4
  • GA17 3
  • B5 3

External Ids for EIF3M Gene

Previous HGNC Symbols for EIF3M Gene

  • PCID1

Previous GeneCards Identifiers for EIF3M Gene

  • GC11P032300

Summaries for EIF3M Gene

Entrez Gene Summary for EIF3M Gene

  • This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]

GeneCards Summary for EIF3M Gene

EIF3M (Eukaryotic Translation Initiation Factor 3 Subunit M) is a Protein Coding gene. Diseases associated with EIF3M include Neuroblastoma and Gliosarcoma. Among its related pathways are Gene Expression and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include binding and translation initiation factor binding.

UniProtKB/Swiss-Prot for EIF3M Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).

Gene Wiki entry for EIF3M Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3M Gene

Genomics for EIF3M Gene

Regulatory Elements for EIF3M Gene

Enhancers for EIF3M Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF3M on UCSC Golden Path with GeneCards custom track

Promoters for EIF3M Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF3M on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF3M Gene

Chromosome:
11
Start:
32,583,767 bp from pter
End:
32,606,262 bp from pter
Size:
22,496 bases
Orientation:
Plus strand

Genomic View for EIF3M Gene

Genes around EIF3M on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3M Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3M Gene

Proteins for EIF3M Gene

  • Protein details for EIF3M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2H7-EIF3M_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit M
    Protein Accession:
    Q7L2H7
    Secondary Accessions:
    • A8K7X4
    • B4E2Q4
    • O60735
    • Q2F836
    • Q53HL6
    • Q9BXW1

    Protein attributes for EIF3M Gene

    Size:
    374 amino acids
    Molecular mass:
    42503 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
    SequenceCaution:
    • Sequence=AAK07542.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK07542.1; Type=Frameshift; Positions=371; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF3M Gene

    Alternative splice isoforms for EIF3M Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3M Gene

Proteomics data for EIF3M Gene at MOPED

Post-translational modifications for EIF3M Gene

  • Ubiquitination at Lys 115, Lys 149, Lys 213, Lys 254, Lys 324, Lys 344, Lys 358, Lys 363, and Lys 365
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3M Gene

Domains & Families for EIF3M Gene

Gene Families for EIF3M Gene

Protein Domains for EIF3M Gene

Suggested Antigen Peptide Sequences for EIF3M Gene

Graphical View of Domain Structure for InterPro Entry

Q7L2H7

UniProtKB/Swiss-Prot:

EIF3M_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the eIF-3 subunit M family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the eIF-3 subunit M family.
genes like me logo Genes that share domains with EIF3M: view

Function for EIF3M Gene

Molecular function for EIF3M Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).
UniProtKB/Swiss-Prot Induction:
By glucose deprivation in neuroblastoma cells.

Gene Ontology (GO) - Molecular Function for EIF3M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IC 17322308
GO:0031369 translation initiation factor binding IEA --
genes like me logo Genes that share ontologies with EIF3M: view
genes like me logo Genes that share phenotypes with EIF3M: view

Animal Models for EIF3M Gene

MGI Knock Outs for EIF3M:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF3M Gene

Localization for EIF3M Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3M Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3M Gene COMPARTMENTS Subcellular localization image for EIF3M gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for EIF3M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3M: view

Pathways & Interactions for EIF3M Gene

genes like me logo Genes that share pathways with EIF3M: view

Gene Ontology (GO) - Biological Process for EIF3M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IC,TAS --
genes like me logo Genes that share ontologies with EIF3M: view

No data available for SIGNOR curated interactions for EIF3M Gene

Drugs & Compounds for EIF3M Gene

No Compound Related Data Available

Transcripts for EIF3M Gene

Unigene Clusters for EIF3M Gene

Eukaryotic translation initiation factor 3, subunit M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3M Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -
SP7: - - -
SP8: - - - - - - - -
SP9: -

Relevant External Links for EIF3M Gene

GeneLoc Exon Structure for
EIF3M
ECgene alternative splicing isoforms for
EIF3M

Expression for EIF3M Gene

mRNA expression in normal human tissues for EIF3M Gene

Protein differential expression in normal tissues from HIPED for EIF3M Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3M Gene



SOURCE GeneReport for Unigene cluster for EIF3M Gene Hs.502244

mRNA Expression by UniProt/SwissProt for EIF3M Gene

Q7L2H7-EIF3M_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with EIF3M: view

Protein tissue co-expression partners for EIF3M Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF3M Gene

Orthologs for EIF3M Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3M Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF3M 35
  • 94.56 (n)
  • 100 (a)
EIF3M 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3M 35
  • 94.56 (n)
  • 100 (a)
EIF3M 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3m 35
  • 91.71 (n)
  • 99.47 (a)
Eif3m 16
Eif3m 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF3M 35
  • 99.91 (n)
  • 100 (a)
EIF3M 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3m 35
  • 90.82 (n)
  • 99.73 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF3M 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3M 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3M 35
  • 85.38 (n)
  • 95.72 (a)
EIF3M 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3M 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3m 35
  • 75.22 (n)
  • 89.57 (a)
Str.3434 35
African clawed frog
(Xenopus laevis)
Amphibia ga17-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.25567 35
eif3m 35
  • 75.22 (n)
  • 88.77 (a)
eif3m 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8249 35
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3M_ANOGA 35
  • 52.38 (n)
  • 48.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango7 35
  • 52.61 (n)
  • 47.3 (a)
Tango7 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cif-1 35
  • 44.29 (n)
  • 32.33 (a)
cif-1 36
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15610 35
  • 45.03 (n)
  • 28.02 (a)
rice
(Oryza sativa)
Liliopsida Os04g0103200 35
  • 44.05 (n)
  • 29.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02813 35
  • 38.38 (n)
  • 28.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1751.03 35
  • 41.52 (n)
  • 24.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5164 36
  • 48 (a)
OneToOne
Species with no ortholog for EIF3M:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3M Gene

ENSEMBL:
Gene Tree for EIF3M (if available)
TreeFam:
Gene Tree for EIF3M (if available)

Paralogs for EIF3M Gene

Pseudogenes.org Pseudogenes for EIF3M Gene

genes like me logo Genes that share paralogs with EIF3M: view

No data available for Paralogs for EIF3M Gene

Variants for EIF3M Gene

Sequence variations from dbSNP and Humsavar for EIF3M Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11557143 - 32,587,078(+) AAGGT(A/G)GACTT intron-variant, reference, missense, utr-variant-5-prime
VAR_036753 A breast cancer sample
VAR_036754 -
rs552512 -- 32,593,455(-) CCAAG(C/T)ATAAA intron-variant
rs7121241 -- 32,600,519(+) GTTTA(C/T)AGTTT intron-variant

Variation tolerance for EIF3M Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for EIF3M Gene

Disorders for EIF3M Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF3M Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search EIF3M in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF3M

Genetic Association Database (GAD)
EIF3M
Human Genome Epidemiology (HuGE) Navigator
EIF3M
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3M
genes like me logo Genes that share disorders with EIF3M: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3M Gene

Publications for EIF3M Gene

  1. The C-terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection. (PMID: 15919899) Perez-Romero P. … Fuller A.O. (J. Virol. 2005) 2 3 4 23 67
  2. A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. (PMID: 15919898) Perez A. … Fuller A.O. (J. Virol. 2005) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for EIF3M Gene

Sources for EIF3M Gene

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