Aliases for EIF3M Gene
- Eukaryotic Translation Initiation Factor 3 Subunit M 2 3 5
- PCI Domain Containing 1 (Herpesvirus Entry Mediator) 2 3
- PCI Domain-Containing Protein 1 3 4
- Fetal Lung Protein B5 3 4
- Hfl-B5 3 4
- PCID1 3 4
- Transport And Golgi Organization 7 Homolog (Drosophila) 2
- Eukaryotic Translation Initiation Factor 3, Subunit M 2
- Transport And Golgi Organization 7 Homolog 3
External Ids for EIF3M Gene
Previous HGNC Symbols for EIF3M Gene
Previous GeneCards Identifiers for EIF3M Gene
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
GeneCards Summary for EIF3M Gene
EIF3M (Eukaryotic Translation Initiation Factor 3 Subunit M) is a Protein Coding gene. Diseases associated with EIF3M include Neuroblastoma and Gliosarcoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include binding and translation initiation factor binding.
UniProtKB/Swiss-Prot for EIF3M Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
(Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).