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EIF3M Gene

protein-coding   GIFtS: 55
GCID: GC11P032564

Eukaryotic Translation Initiation Factor 3, Subunit M

(Previous name: PCI domain containing 1 (herpesvirus entry mediator))
(Previous symbol: PCID1)
  See EIF3M-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit M1 2     Dendritic Cell Protein2
PCID11 2 3 5     Eukaryotic Translation Initiation Factor 3 Subunit M2
PCI Domain Containing 1 (Herpesvirus Entry Mediator)1 2     hfl-B52
Fetal Lung Protein B52 3     Transport And Golgi Organization 7 Homolog2
PCI Domain-Containing Protein 12 3     HFLB53
B52 5     eIF3m3
Transport And Golgi Organization 7 Homolog (Drosophila)1     hFL-B53
TANGO72     GA175
B5 Receptor2     

External Ids:    HGNC: 244601   Entrez Gene: 104802   Ensembl: ENSG000001491007   OMIM: 6096415   UniProtKB: Q7L2H73   

Export aliases for EIF3M gene to outside databases

Previous GC identifer: GC11P032300


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF3M Gene:
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3)
required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines.
Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by
preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome.
(provided by RefSeq, Dec 2011)

GeneCards Summary for EIF3M Gene:
EIF3M (eukaryotic translation initiation factor 3, subunit M) is a protein-coding gene. Diseases associated with EIF3M include cystic lymphangioma. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot: EIF3M_HUMAN, Q7L2H7
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2)

Gene Wiki entry for EIF3M Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3M gene promoter:
         AREB6   SRY   AML1a   HFH-1   FOXD1   SEF-1 (1)   MIF-1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3M promoter sequence
   Search Chromatin IP Primers for EIF3M

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

EIF3M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3M gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P032564:  view genomic region     (about GC identifiers)

Start:
32,605,344 bp from pter      End:
32,627,808 bp from pter
Size:
22,465 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EIF3M_HUMAN, Q7L2H7 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit M  
Size: 374 amino acids; 42503 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3
Mass spectrometry: Mass=42413.8; Method=Unknown; Range=1-374; Source=PubMed:17322308;
Mass spectrometry: Mass=42414.7; Mass_error=0.2; Method=MALDI; Range=1-374; Source=PubMed:18599441;
Sequence caution: Sequence=AAK07542.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAK07542.1; Type=Frameshift; Positions=371;
Secondary accessions: A8K7X4 O60735 Q2F836 Q53HL6 Q9BXW1

Explore the universe of human proteins at neXtProt for EIF3M: NX_Q7L2H7

Explore proteomics data for EIF3M at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115, Lys149, Lys213, Lys254, Lys324, Lys344, Lys358, Lys363, Lys365
  • Modification sites at PhosphoSitePlus

  • See EIF3M Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006351.2  
    ENSEMBL proteins: 
     ENSP00000435501   ENSP00000436049   ENSP00000434080   ENSP00000436787   ENSP00000435834  
     ENSP00000319910   ENSP00000432286   ENSP00000432891   ENSP00000432139  

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    Cloud-Clone Corp. Proteins for EIF3M

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR027528 eIF3m
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q7L2H7

    ProtoNet protein and cluster: Q7L2H7

    UniProtKB/Swiss-Prot: EIF3M_HUMAN, Q7L2H7
    Similarity: Belongs to the eIF-3 subunit M family
    Similarity: Contains 1 PCI domain


    Find genes that share domains with EIF3M           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3M_HUMAN, Q7L2H7
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
    May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2)
    Induction: By glucose deprivation in neuroblastoma cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IC17322308
    GO:0005488binding ----
    GO:0005515protein binding IPI18599441
         
    Find genes that share ontologies with EIF3M           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for EIF3M:
     Increased Hepatitis C virus re  Increased S DNA content 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Eif3m):
     adipose tissue  behavior/neurological  embryogenesis  growth/size/body  homeostasis/metabolism 
     liver/biliary system  mortality/aging  renal/urinary system 

    Find genes that share phenotypes with EIF3M           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF3M
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF3M
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    miRTarBase miRNAs that target EIF3M:
    hsa-mir-324-3p (MIRT043004), hsa-mir-615-3p (MIRT040019), hsa-mir-744-5p (MIRT037709), hsa-mir-16-5p (MIRT031556), hsa-mir-193b-3p (MIRT041230), hsa-mir-124-3p (MIRT022389), hsa-mir-106a-5p (MIRT048348)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3M_HUMAN, Q7L2H7: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--

    Find genes that share ontologies with EIF3M           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3M
    Interactions:

        Search GeneGlobe Interaction Network for EIF3M

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3M (Q7L2H71, 2, 3 ENSP000003199104) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3FO003032, 3, ENSP000003100404MINT-63044 I2D: score=7 STRING: ENSP00000310040
    NME2P223923, ENSP000003655724I2D: score=1 STRING: ENSP00000365572
    EIF3HO153723, ENSP000002766824I2D: score=2 STRING: ENSP00000276682
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0002183cytoplasmic translational initiation IBA--
    GO:0006413translational initiation IC17322308
    GO:0006446regulation of translational initiation IEA--

    Find genes that share ontologies with EIF3M           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3M



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF3M gene: 
    NM_006360.4  

    Unigene Cluster for EIF3M:

    Eukaryotic translation initiation factor 3, subunit M
    Hs.502244  [show with all ESTs]
    Unigene Representative Sequence: AK001768
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531921 ENST00000531120(uc001mtu.3) ENST00000531186 ENST00000525782
    ENST00000524896(uc010ref.2) ENST00000532444 ENST00000323213 ENST00000524711
    ENST00000530026 ENST00000532054 ENST00000533439 ENST00000526267 ENST00000525054

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      QuantiTect SYBR Green Assays in human, mouse, rat EIF3M
      QuantiFast Probe-based Assays in human, mouse, rat EIF3M

    Additional mRNA sequence: 

    AF277183.1 AK001768.1 AK131064.1 AK222564.1 AK292139.1 AK300002.1 AK304378.1 AK307121.1 
    AK312512.1 AY769947.1 BC011937.2 BC019103.2 BC020458.1 BC051292.1 CR450300.1 DQ185042.1 

    Selected DOTS entries (see all 33):

    DT.91981098  DT.219492  DT.100684505  DT.100055729  DT.100684498  DT.92066770  DT.97860264  DT.100684501 
    DT.100868304  DT.100684511  DT.97860263  DT.100684510  DT.95169649  DT.100684502  DT.100684509  DT.120699839 
    DT.95169635  DT.100058371  DT.120699844  DT.92466015  DT.95169653  DT.95169662  DT.100684503  DT.100684507 

    Selected AceView cDNA sequences (see all 806):

    AA558610 BI522449 BE885875 CB121228 N78590 AA970216 CA412683 CA419134 
    AI184292 AA521271 N39236 AI194007 BM973805 BM463675 BX437269 BC020458 
    BQ020646 BM909905 BI335161 AI719141 CR608161 CB138433 CR593695 BU609183 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF3M (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
    SP1:                          -     -     -                       -                       -           -                       -           -         
    SP2:                                                                                                  -                       -                     
    SP3:                          -     -                             -                                                                                 
    SP4:                                                                                                                          -                     
    SP5:                                                              -                                                                                 


    ECgene alternative splicing isoforms for EIF3M

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3M expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAGAATAT
    EIF3M Expression
    About this image


    EIF3M expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    EIF3M Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3M Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502244

    UniProtKB/Swiss-Prot: EIF3M_HUMAN, Q7L2H7
    Tissue specificity: Broadly expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3M gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3m1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 91.71(n)1
    99.47(a)1
      2 (55.06 cM)5
    982211  NM_145380.21  NP_663355.11 
     1049996565 
    chicken
    (Gallus gallus)
    Aves EIF3M1 eukaryotic translation initiation factor 3, subunit more 85.38(n)
    95.72(a)
      421602  NM_001006406.1  NP_001006406.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3M6
    eukaryotic translation initiation factor 3, subuni...
    94(a)
    1 ↔ 1
    1(61258294-61279801)
    African clawed frog
    (Xenopus laevis)
    Amphibia ga17-prov2 dendritic cell protein 75.98(n)    BC041198.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.255672 Danio rerio cDNA clone MGC63996 IMAGE6792584, complete more 76.52(n)    BC053188.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango71 Transport and Golgi organization 7 52.61(n)
    47.3(a)
      36565  NM_137088.3  NP_610932.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cif-11 cif-1 44.29(n)
    32.33(a)
      177236  NM_068217.5  NP_500618.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G156101 AT5G15610 45.03(n)
    28.02(a)
      831413  NM_180495.1  NP_850826.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g01032001 Os04g0103200 44.05(n)
    29.9(a)
      4334895  NM_001058533.1  NP_001051998.1 


    ENSEMBL Gene Tree for EIF3M (if available)
    TreeFam Gene Tree for EIF3M (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3M gene

    Find genes that share paralogs with EIF3M           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for EIF3M
    PGOHUM00000258440


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EIF3M (see all 423)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0367534
    A breast cancer sample4--see VAR_0367532 E G mis40--------
    rs801433161,2
    C,F--32603448(+) CTCAAC/ACTTGT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs754065021,2
    F--32603449(+) TCAACC/ATTGTT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1929593231,2
    --32603451(+) AACCTC/TGTTTT 1 -- us2k10--------
    rs1436713611,2
    C--32603489(+) TTGAAA/GTATAA 1 -- us2k10--------
    rs108359481,2
    C,F,A,H--32603516(+) CTGCAC/TATTTT 1 -- us2k112Minor allele frequency- T:0.11NS EA NA WA 772
    rs2018861,2
    C,F,A--32603544(-) tataaC/Aatttt 1 -- us2k19Minor allele frequency- A:0.47NA WA CSA EA 368
    rs1852334941,2
    --32603553(+) TATATA/GTATAC 1 -- us2k10--------
    rs1115521151,2
    C,F--32603581(+) AGTCAA/GAATAA 1 -- us2k12Minor allele frequency- G:0.03CSA WA 120
    rs1905581101,2
    --32603657(+) ACCCAA/GTCCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EIF3M (32605344 - 32627808 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EIF3M: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing EIF3M
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3M

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609641    OMIM disorders: --

    1 disease for EIF3M:    
    About MalaCards
    cystic lymphangioma

    1 disease from the University of Copenhagen DISEASES database for EIF3M:
    Cystic lymphangioma

    Find genes that share disorders with EIF3M           About GenesLikeMe

    Genetic Association Database (GAD): EIF3M
    Human Genome Epidemiology (HuGE) Navigator: EIF3M (1 document)

    Export disorders for EIF3M gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3M gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with EIF3M)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The C-terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection. (PubMed id 15919899)1, 2, 3, 9 Perez-Romero P. and Fuller A.O. (J. Virol. 2005)
    2. A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. (PubMed id 15919898)1, 2, 3 Perez A.... Fuller A.O. (J. Virol. 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells. (PubMed id 17719568)1, 2 Kobayashi K.... Russo V.C. (Brain Res. 2007)
    6. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10480 HGNC: 24460 AceView: GA17 Ensembl:ENSG00000149100 euGenes: HUgn10480
    ECgene: EIF3M H-InvDB: EIF3M

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF3M Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EIF3M gene:
    Search GeneIP for patents involving EIF3M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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