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Aliases for EIF3M Gene

Aliases for EIF3M Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit M 2 3 5
  • PCI Domain Containing 1 (Herpesvirus Entry Mediator) 2 3
  • PCI Domain-Containing Protein 1 3 4
  • Fetal Lung Protein B5 3 4
  • Hfl-B5 3 4
  • PCID1 3 4
  • Transport And Golgi Organization 7 Homolog (Drosophila) 2
  • Eukaryotic Translation Initiation Factor 3, Subunit M 2
  • Transport And Golgi Organization 7 Homolog 3
  • Dendritic Cell Protein 3
  • B5 Receptor 3
  • TANGO7 3
  • HFLB5 4
  • EIF3m 4
  • GA17 3
  • B5 3

External Ids for EIF3M Gene

Previous HGNC Symbols for EIF3M Gene

  • PCID1

Previous GeneCards Identifiers for EIF3M Gene

  • GC11P032300

Summaries for EIF3M Gene

Entrez Gene Summary for EIF3M Gene

  • This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]

GeneCards Summary for EIF3M Gene

EIF3M (Eukaryotic Translation Initiation Factor 3 Subunit M) is a Protein Coding gene. Diseases associated with EIF3M include Neuroblastoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. GO annotations related to this gene include binding and translation initiation factor binding.

UniProtKB/Swiss-Prot for EIF3M Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

  • (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).

Gene Wiki entry for EIF3M Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3M Gene

Genomics for EIF3M Gene

Regulatory Elements for EIF3M Gene

Enhancers for EIF3M Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F033159 0.6 ENCODE 28.3 +577.6 577550 3.4 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NAT10 EIF3M HIPK3 CSTF3 TCP11L1 PIGCP1 DEPDC7 CSTF3-AS1 PIR59958
GH11F032582 1 ENCODE 20.9 +0.6 587 2.8 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 EIF3M RCN1 HNRNPA3P9
GH11F032706 1.1 FANTOM5 Ensembl ENCODE 19.2 +123.6 123576 1.3 ZNF366 SCRT2 RCOR1 FOS CREM ZNF362 CEBPB JUNB ZNF264 MEF2D EIF3M CCDC73 HNRNPA3P9 ENSG00000244535
GH11F032090 0.5 ENCODE 11.5 -492.2 -492243 2.9 PKNOX1 GLI4 DMAP1 ZNF48 ZNF2 GTF3C2 GLIS2 FOS KLF7 SP3 RCN1 EIF3M EIF4A2P5 ENSG00000255252
GH11F033015 0.5 ENCODE 11.5 +433.5 433492 4.0 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 PIGCP1 EIF3M DEPDC7 TCP11L1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EIF3M on UCSC Golden Path with GeneCards custom track

Promoters for EIF3M Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108424 633 2401 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for EIF3M Gene

Chromosome:
11
Start:
32,583,767 bp from pter
End:
32,606,262 bp from pter
Size:
22,496 bases
Orientation:
Plus strand

Genomic View for EIF3M Gene

Genes around EIF3M on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3M Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3M Gene

Proteins for EIF3M Gene

  • Protein details for EIF3M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2H7-EIF3M_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit M
    Protein Accession:
    Q7L2H7
    Secondary Accessions:
    • A8K7X4
    • B4E2Q4
    • O60735
    • Q2F836
    • Q53HL6
    • Q9BXW1

    Protein attributes for EIF3M Gene

    Size:
    374 amino acids
    Molecular mass:
    42503 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
    SequenceCaution:
    • Sequence=AAK07542.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK07542.1; Type=Frameshift; Positions=371; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF3M Gene

    Alternative splice isoforms for EIF3M Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3M Gene

Post-translational modifications for EIF3M Gene

  • Ubiquitination at Lys 115, Lys 149, Lys 213, Lys 254, Lys 324, Lys 344, Lys 358, Lys 363, and Lys 365
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3M Gene

Domains & Families for EIF3M Gene

Gene Families for EIF3M Gene

Protein Domains for EIF3M Gene

Suggested Antigen Peptide Sequences for EIF3M Gene

Graphical View of Domain Structure for InterPro Entry

Q7L2H7

UniProtKB/Swiss-Prot:

EIF3M_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the eIF-3 subunit M family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the eIF-3 subunit M family.
genes like me logo Genes that share domains with EIF3M: view

Function for EIF3M Gene

Molecular function for EIF3M Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
UniProtKB/Swiss-Prot Function:
(Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).
UniProtKB/Swiss-Prot Induction:
By glucose deprivation in neuroblastoma cells.

Gene Ontology (GO) - Molecular Function for EIF3M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 25849773
GO:0005515 protein binding IPI 16169070
GO:0031369 translation initiation factor binding IEA --
genes like me logo Genes that share ontologies with EIF3M: view
genes like me logo Genes that share phenotypes with EIF3M: view

Animal Models for EIF3M Gene

MGI Knock Outs for EIF3M:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF3M Gene

Localization for EIF3M Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3M Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3M Gene COMPARTMENTS Subcellular localization image for EIF3M gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for EIF3M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3M: view

Pathways & Interactions for EIF3M Gene

genes like me logo Genes that share pathways with EIF3M: view

Gene Ontology (GO) - Biological Process for EIF3M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002183 cytoplasmic translational initiation IBA --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3M: view

No data available for SIGNOR curated interactions for EIF3M Gene

Transcripts for EIF3M Gene

Unigene Clusters for EIF3M Gene

Eukaryotic translation initiation factor 3, subunit M:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3M Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -
SP7: - - -
SP8: - - - - - - - -
SP9: -

Relevant External Links for EIF3M Gene

GeneLoc Exon Structure for
EIF3M
ECgene alternative splicing isoforms for
EIF3M

Expression for EIF3M Gene

mRNA expression in normal human tissues for EIF3M Gene

Protein differential expression in normal tissues from HIPED for EIF3M Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3M Gene



Protein tissue co-expression partners for EIF3M Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3M Gene:

EIF3M

SOURCE GeneReport for Unigene cluster for EIF3M Gene:

Hs.502244

mRNA Expression by UniProt/SwissProt for EIF3M Gene:

Q7L2H7-EIF3M_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with EIF3M: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF3M Gene

Orthologs for EIF3M Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3M Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3M 34 35
  • 99.91 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF3M 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3M 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3M 34 35
  • 94.56 (n)
dog
(Canis familiaris)
Mammalia EIF3M 34 35
  • 94.56 (n)
mouse
(Mus musculus)
Mammalia Eif3m 34 16 35
  • 91.71 (n)
rat
(Rattus norvegicus)
Mammalia Eif3m 34
  • 90.82 (n)
chicken
(Gallus gallus)
Aves EIF3M 34 35
  • 85.38 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3M 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3m 34
  • 75.22 (n)
Str.3434 34
African clawed frog
(Xenopus laevis)
Amphibia ga17-prov 34
zebrafish
(Danio rerio)
Actinopterygii eif3m 34 35
  • 75.22 (n)
Dr.25567 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8249 34
fruit fly
(Drosophila melanogaster)
Insecta Tango7 34 35
  • 52.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3M_ANOGA 34
  • 52.38 (n)
worm
(Caenorhabditis elegans)
Secernentea cif-1 34 35
  • 44.29 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15610 34
  • 45.03 (n)
rice
(Oryza sativa)
Liliopsida Os04g0103200 34
  • 44.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5164 35
  • 48 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1751.03 34
  • 41.52 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02813 34
  • 38.38 (n)
Species where no ortholog for EIF3M was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3M Gene

ENSEMBL:
Gene Tree for EIF3M (if available)
TreeFam:
Gene Tree for EIF3M (if available)

Paralogs for EIF3M Gene

Pseudogenes.org Pseudogenes for EIF3M Gene

genes like me logo Genes that share paralogs with EIF3M: view

No data available for Paralogs for EIF3M Gene

Variants for EIF3M Gene

Sequence variations from dbSNP and Humsavar for EIF3M Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036753 A breast cancer sample
rs1049240 -- 32,602,355(+) AAAAT(C/T)TGAAC reference, synonymous-codon, utr-variant-3-prime
rs10767950 -- 32,601,502(+) TCTTT(A/T)AAAAA intron-variant
rs10835948 -- 32,581,970(+) CTGCA(C/T)ATTTT upstream-variant-2KB
rs10835949 -- 32,588,386(+) ttcat(C/T)tgaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3M Gene

Variant ID Type Subtype PubMed ID
esv3350453 CNV duplication 20981092
nsv983000 CNV duplication 23825009

Variation tolerance for EIF3M Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3M Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3M

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3M Gene

Disorders for EIF3M Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF3M Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search EIF3M in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF3M

Genetic Association Database (GAD)
EIF3M
Human Genome Epidemiology (HuGE) Navigator
EIF3M
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3M
genes like me logo Genes that share disorders with EIF3M: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3M Gene

Publications for EIF3M Gene

  1. The C-terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection. (PMID: 15919899) Perez-Romero P. … Fuller A.O. (J. Virol. 2005) 2 3 4 22 64
  2. A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. (PMID: 15919898) Perez A. … Fuller A.O. (J. Virol. 2005) 2 3 4 64
  3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M. … Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64

Products for EIF3M Gene

Sources for EIF3M Gene

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