Aliases for EIF3L Gene
- Eukaryotic Translation Initiation Factor 3 Subunit L 2 3 5
- Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein 3 4
- Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein 3 4
- EIF3S6IP 3 4
- EIF3EIP 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 6 Interacting Protein 2
- Eukaryotic Translation Initiation Factor 3, Subunit E Interacting Protein 2
- Eukaryotic Translation Initiation Factor 3, Subunit L 2
External Ids for EIF3L Gene
Previous HGNC Symbols for EIF3L Gene
Previous GeneCards Identifiers for EIF3L Gene
GeneCards Summary for EIF3L Gene
EIF3L (Eukaryotic Translation Initiation Factor 3 Subunit L) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF3L Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).