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Aliases for EIF3L Gene

Aliases for EIF3L Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit L 2 3 5
  • Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein 3 4
  • Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein 3 4
  • EIF3S6IP 3 4
  • EIF3EIP 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 Interacting Protein 2
  • Eukaryotic Translation Initiation Factor 3, Subunit E Interacting Protein 2
  • Eukaryotic Translation Initiation Factor 3, Subunit L 2
  • EIEF Associated Protein HSPC021 3
  • EIF3S11 3
  • HSPC021 3
  • HSPC025 3
  • MSTP005 3
  • EIF3l 4

External Ids for EIF3L Gene

Previous HGNC Symbols for EIF3L Gene

  • EIF3S6IP
  • EIF3EIP

Previous GeneCards Identifiers for EIF3L Gene

  • GC22P036575
  • GC22P038244
  • GC22P021211

Summaries for EIF3L Gene

GeneCards Summary for EIF3L Gene

EIF3L (Eukaryotic Translation Initiation Factor 3 Subunit L) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3L Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

  • (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3L Gene

Genomics for EIF3L Gene

Regulatory Elements for EIF3L Gene

Enhancers for EIF3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G037931 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.1 +84.7 84675 2.9 HDGF MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF207 ZNF143 GALR3 EIF3L ENSG00000230149 ENSG00000273076 ENSG00000272669 ENSG00000225450 RNU6-900P MICALL1 SOX10 PRDX3P1
GH22G037801 1.7 FANTOM5 ENCODE dbSUPER 11.7 -42.9 -42919 7.3 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GCAT H1F0 GALR3 ANKRD54 MIR659 EIF3L PRDX3P1 JOSD1 C1QTNF6 CSNK1E
GH22G037847 1.1 ENCODE 14.9 +0.7 691 2.6 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 EIF3L H1F0 GCAT ENSG00000230149 ENSG00000273076 BAIAP2L2 PIR48437 GC22M041758
GH22G037880 0.9 ENCODE dbSUPER 18.1 +32.5 32516 1.1 JUN ZNF394 ZNF121 JUND IKZF1 FOS MLLT1 SP7 EIF3L MIR659 ANKRD54 GCAT H1F0 ENSG00000279738 GC22P037892
GH22G037886 1.3 ENCODE dbSUPER 11.9 +39.3 39313 2.3 FOXA2 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF48 ZNF121 ELK1 FOS GALR3 ANKRD54 MIR659 EIF3L GCAT H1F0 POLR2F SOX10 GC22P037892 ENSG00000279738
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3L on UCSC Golden Path with GeneCards custom track

Promoters for EIF3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146076 952 2001 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for EIF3L Gene

Chromosome:
22
Start:
37,848,448 bp from pter
End:
37,889,407 bp from pter
Size:
40,960 bases
Orientation:
Plus strand

Genomic View for EIF3L Gene

Genes around EIF3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3L Gene

Proteins for EIF3L Gene

  • Protein details for EIF3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y262-EIF3L_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit L
    Protein Accession:
    Q9Y262
    Secondary Accessions:
    • B2RDG6
    • B4DYB2
    • G8JLH4
    • Q53HQ1
    • Q53HT4
    • Q5QTR1
    • Q5TI15
    • Q6ICD2

    Protein attributes for EIF3L Gene

    Size:
    564 amino acids
    Molecular mass:
    66727 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
    SequenceCaution:
    • Sequence=CAG30322.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX14899.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF3L Gene

    Alternative splice isoforms for EIF3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3L Gene

Post-translational modifications for EIF3L Gene

  • Ubiquitination at isoforms=2101, isoforms=2403, and Lys419
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3L Gene

Domains & Families for EIF3L Gene

Gene Families for EIF3L Gene

Protein Domains for EIF3L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y262

UniProtKB/Swiss-Prot:

EIF3L_HUMAN :
  • Belongs to the eIF-3 subunit L family.
Family:
  • Belongs to the eIF-3 subunit L family.
genes like me logo Genes that share domains with EIF3L: view

Function for EIF3L Gene

Molecular function for EIF3L Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Ontology (GO) - Molecular Function for EIF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 17581632
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EIF3L: view
genes like me logo Genes that share phenotypes with EIF3L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3L Gene

Localization for EIF3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3L gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EIF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IEA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF3L: view

Pathways & Interactions for EIF3L Gene

genes like me logo Genes that share pathways with EIF3L: view

Gene Ontology (GO) - Biological Process for EIF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0075525 viral translational termination-reinitiation IDA 21347434
genes like me logo Genes that share ontologies with EIF3L: view

No data available for SIGNOR curated interactions for EIF3L Gene

Drugs & Compounds for EIF3L Gene

No Compound Related Data Available

Transcripts for EIF3L Gene

Unigene Clusters for EIF3L Gene

Eukaryotic translation initiation factor 3, subunit L:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: -

ExUns: 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for EIF3L Gene

GeneLoc Exon Structure for
EIF3L
ECgene alternative splicing isoforms for
EIF3L

Expression for EIF3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3L Gene

This gene is overexpressed in Saliva (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3L Gene



Protein tissue co-expression partners for EIF3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3L Gene:

EIF3L

SOURCE GeneReport for Unigene cluster for EIF3L Gene:

Hs.446852

Evidence on tissue expression from TISSUES for EIF3L Gene

  • Intestine(5)
  • Nervous system(5)
  • Blood(4.9)
  • Liver(4.9)
  • Lung(4.7)
  • Kidney(4.6)
  • Skin(4.6)
  • Heart(4.5)
  • Spleen(4.5)
  • Stomach(4.5)
  • Eye(4.4)
  • Muscle(4)
  • Pancreas(3.4)
  • Thyroid gland(2.4)
  • Bone marrow(2.3)
  • Lymph node(2.3)
  • Adrenal gland(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with EIF3L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3L Gene

Orthologs for EIF3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3L 35 34
  • 99.53 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3L 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3L 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3L 34 35
  • 93.03 (n)
dog
(Canis familiaris)
Mammalia EIF3L 35 34
  • 92.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3l 34 16 35
  • 88.89 (n)
chicken
(Gallus gallus)
Aves EIF3L 34 35
  • 84.63 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3L 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3l 34
  • 81.49 (n)
MGC75896 34
African clawed frog
(Xenopus laevis)
Amphibia eif3s6ip-prov 34
zebrafish
(Danio rerio)
Actinopterygii eif3s6ip 34 35
  • 80.17 (n)
Dr.26663 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8938 34
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3L_ANOGA 34
  • 63.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5642 34 35
  • 60.68 (n)
worm
(Caenorhabditis elegans)
Secernentea C17G10.9 35
  • 41 (a)
OneToMany
C03H5.5 35
  • 17 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25757 34
  • 57.36 (n)
rice
(Oryza sativa)
Liliopsida Os01g0229100 34
  • 56.34 (n)
Os.10033 34
barley
(Hordeum vulgare)
Liliopsida Hv.2732 34
corn
(Zea mays)
Liliopsida Zm.5792 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11291 35
  • 61 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06279 34
  • 59.34 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3552 34
Species where no ortholog for EIF3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3L Gene

ENSEMBL:
Gene Tree for EIF3L (if available)
TreeFam:
Gene Tree for EIF3L (if available)

Paralogs for EIF3L Gene

No data available for Paralogs for EIF3L Gene

Variants for EIF3L Gene

Sequence variations from dbSNP and Humsavar for EIF3L Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000063270 -- 37,864,361(+) GTGGT(A/G)GTTAC intron-variant
rs1000077762 -- 37,879,777(+) CCTCA(C/T)TGGCC intron-variant
rs1000143606 -- 37,861,203(+) CTAAG(A/G)AGGTC intron-variant
rs1000170134 -- 37,857,204(+) AAAAT(A/G)CAAAA intron-variant
rs1000266017 -- 37,856,745(+) AGGTG(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3L Gene

Variant ID Type Subtype PubMed ID
esv2661617 CNV deletion 23128226
esv2724220 CNV deletion 23290073
esv2758838 CNV loss 17122850
esv3893482 CNV gain 25118596
nsv191391 CNV deletion 16902084
nsv964627 CNV duplication 23825009

Variation tolerance for EIF3L Gene

Residual Variation Intolerance Score: 7.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3L Gene

Disorders for EIF3L Gene

Relevant External Links for EIF3L

Genetic Association Database (GAD)
EIF3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3L

No disorders were found for EIF3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3L Gene

Publications for EIF3L Gene

  1. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. (PMID: 11590142) Morris-Desbois C. … Jalinot P. (J. Biol. Chem. 2001) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M. … Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E. … Leary J.A. (Mol. Cell. Proteomics 2007) 3 4 64

Products for EIF3L Gene

Sources for EIF3L Gene

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