Aliases for EIF3L Gene
- Eukaryotic Translation Initiation Factor 3 Subunit L 2 3 5
- Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein 3 4
- Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit L 2 3
- EIF3S6IP 3 4
- EIF3EIP 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 6 Interacting Protein 2
- Eukaryotic Translation Initiation Factor 3, Subunit E Interacting Protein 2
External Ids for EIF3L Gene
Previous HGNC Symbols for EIF3L Gene
Previous GeneCards Identifiers for EIF3L Gene
GeneCards Summary for EIF3L Gene
EIF3L (Eukaryotic Translation Initiation Factor 3 Subunit L) is a Protein Coding gene. Diseases associated with EIF3L include yellow fever. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF3L Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).