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Aliases for EIF3L Gene

Aliases for EIF3L Gene

  • Eukaryotic Translation Initiation Factor 3, Subunit L 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein 3 4
  • Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein 3 4
  • EIF3S6IP 3 4
  • EIF3EIP 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 Interacting Protein 2
  • Eukaryotic Translation Initiation Factor 3, Subunit E Interacting Protein 2
  • Eukaryotic Translation Initiation Factor 3 Subunit L 3
  • EIEF Associated Protein HSPC021 3
  • EIF3S11 3
  • HSPC021 3
  • HSPC025 3
  • MSTP005 3
  • EIF3l 4

External Ids for EIF3L Gene

Previous HGNC Symbols for EIF3L Gene

  • EIF3S6IP
  • EIF3EIP

Previous GeneCards Identifiers for EIF3L Gene

  • GC22P036575
  • GC22P038244
  • GC22P021211

Summaries for EIF3L Gene

GeneCards Summary for EIF3L Gene

EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L) is a Protein Coding gene. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3L Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3L Gene

Genomics for EIF3L Gene

Regulatory Elements for EIF3L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF3L Gene

Start:
37,848,774 bp from pter
End:
37,889,407 bp from pter
Size:
40,634 bases
Orientation:
Plus strand

Genomic View for EIF3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3L Gene

Proteins for EIF3L Gene

  • Protein details for EIF3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y262-EIF3L_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit L
    Protein Accession:
    Q9Y262
    Secondary Accessions:
    • B2RDG6
    • B4DYB2
    • G8JLH4
    • Q53HQ1
    • Q53HT4
    • Q5QTR1
    • Q5TI15
    • Q6ICD2

    Protein attributes for EIF3L Gene

    Size:
    564 amino acids
    Molecular mass:
    66727 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
    SequenceCaution:
    • Sequence=CAG30322.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX14899.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF3L Gene

    Alternative splice isoforms for EIF3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3L Gene

Proteomics data for EIF3L Gene at MOPED

Post-translational modifications for EIF3L Gene

  • Ubiquitination at Lys101, Lys403, Lys419, and Lys437
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for EIF3L Gene

Domains for EIF3L Gene

Protein Domains for EIF3L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y262

UniProtKB/Swiss-Prot:

EIF3L_HUMAN :
  • Q9Y262
Family:
  • Belongs to the eIF-3 subunit L family.
genes like me logo Genes that share domains with EIF3L: view

No data available for Gene Families for EIF3L Gene

Function for EIF3L Gene

Molecular function for EIF3L Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Ontology (GO) - Molecular Function for EIF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IDA 17581632
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with EIF3L: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF3L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF3L Gene

Localization for EIF3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3L Gene COMPARTMENTS Subcellular localization image for EIF3L gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EIF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IEA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus --
GO:0005737 cytoplasm --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
genes like me logo Genes that share ontologies with EIF3L: view

Pathways for EIF3L Gene

SuperPathways for EIF3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006413 translational initiation IDA 17581632
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3L: view

No data available for Pathways by source for EIF3L Gene

Transcripts for EIF3L Gene

Unigene Clusters for EIF3L Gene

Eukaryotic translation initiation factor 3, subunit L:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF3L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: -

ExUns: 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for EIF3L Gene

GeneLoc Exon Structure for
EIF3L
ECgene alternative splicing isoforms for
EIF3L

Expression for EIF3L Gene

mRNA expression in normal human tissues for EIF3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for EIF3L Gene

This gene is overexpressed in Saliva (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3L Gene

SOURCE GeneReport for Unigene cluster for EIF3L Gene Hs.446852

genes like me logo Genes that share expressions with EIF3L: view

Expression partners for EIF3L Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3L Gene

Orthologs for EIF3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF3L 35
  • 93.03 (n)
  • 99.65 (a)
EIF3L 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3L 35
  • 92.08 (n)
  • 99.82 (a)
EIF3L 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3l 35
  • 88.89 (n)
  • 99.11 (a)
Eif3l 16
Eif3l 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF3L 35
  • 99.53 (n)
  • 99.82 (a)
EIF3L 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3L 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3L 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3L 35
  • 84.63 (n)
  • 97.87 (a)
EIF3L 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3L 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3l 35
  • 81.49 (n)
  • 95.37 (a)
MGC75896 35
African clawed frog
(Xenopus laevis)
Amphibia eif3s6ip-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26663 35
eif3s6ip 35
  • 80.17 (n)
  • 92.29 (a)
eif3s6ip 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8938 35
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3L_ANOGA 35
  • 63.11 (n)
  • 59.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5642 35
  • 60.68 (n)
  • 56.52 (a)
CG5642 36
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C03H5.5 36
  • 17 (a)
OneToMany
C17G10.9 36
  • 41 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25757 35
  • 57.36 (n)
  • 48.63 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2732 35
rice
(Oryza sativa)
Liliopsida Os.10033 35
Os01g0229100 35
  • 56.34 (n)
  • 47.61 (a)
corn
(Zea mays)
Liliopsida Zm.5792 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3552 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06279 35
  • 59.34 (n)
  • 52.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11291 36
  • 61 (a)
OneToOne
Species with no ortholog for EIF3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3L Gene

ENSEMBL:
Gene Tree for EIF3L (if available)
TreeFam:
Gene Tree for EIF3L (if available)

Paralogs for EIF3L Gene

Pseudogenes.org Pseudogenes for EIF3L Gene

genes like me logo Genes that share paralogs with EIF3L: view

No data available for Paralogs for EIF3L Gene

Variants for EIF3L Gene

Sequence variations from dbSNP and Humsavar for EIF3L Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs8646 -- 37,888,529(-) TTTCA(C/T)GGTAG utr-variant-3-prime
rs9466 -- 37,877,742(+) CGTAT(C/T)GATGA synonymous-codon, reference
rs139838 -- 37,872,915(+) acact(A/G)tcagt intron-variant
rs139840 -- 37,873,434(+) CTGGG(-/A)CTACA intron-variant
rs139842 -- 37,876,922(+) CTGTT(C/T)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3L Gene

Variant ID Type Subtype PubMed ID
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
nsv191391 CNV Loss 16902084
esv2661617 CNV Deletion 23128226
esv2724220 CNV Deletion 23290073

Relevant External Links for EIF3L Gene

HapMap Linkage Disequilibrium report
EIF3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3L Gene

Disorders for EIF3L Gene

Relevant External Links for EIF3L

Genetic Association Database (GAD)
EIF3L

No disorders were found for EIF3L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for EIF3L Gene

Publications for EIF3L Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. (PMID: 11590142) Morris-Desbois C. … Jalinot P. (J. Biol. Chem. 2001) 2 3 4
  3. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PMID: 12393749) Yuan X. … Grummt I. (EMBO Rep. 2002) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for EIF3L Gene

Sources for EIF3L Gene

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