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EIF3L Gene

protein-coding   GIFtS: 50
GCID: GC22P038244

Eukaryotic Translation Initiation Factor 3, Subunit L

(Previous names: eukaryotic translation initiation factor 3, subunit 6 interacting...)
(Previous symbols: EIF3S6IP, EIF3EIP)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit L1 2     EIF3S112
EIF3EIP1 2 3     HSPC0212
EIF3S6IP1 2 3     HSPC0252
Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein2 3     MSTP0052
Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein2 3     EIEF Associated Protein HSPC0212
Eukaryotic Translation Initiation Factor 3, Subunit 6 Interacting Protein1     Eukaryotic Translation Initiation Factor 3 Subunit L2
Eukaryotic Translation Initiation Factor 3, Subunit E Interacting Protein1     eIF3l3

External Ids:    HGNC: 181381   Entrez Gene: 513862   Ensembl: ENSG000001001297   UniProtKB: Q9Y2623   

Export aliases for EIF3L gene to outside databases

Previous GC identifers: GC22P036575 GC22P021211


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3L Gene:
EIF3L (eukaryotic translation initiation factor 3, subunit L) is a protein-coding gene. Diseases associated with EIF3L include malaria. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot: EIF3L_HUMAN, Q9Y262
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3L (EIF3EIP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3L gene promoter:
         ISGF-3   Pax-5   Arnt   CBF-C   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3L promoter sequence
   Search Chromatin IP Primers for EIF3L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q

EIF3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3L gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038244:  view genomic region     (about GC identifiers)

Start:
38,244,875 bp from pter      End:
38,285,414 bp from pter
Size:
40,540 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EIF3L_HUMAN, Q9Y262 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit L  
Size: 564 amino acids; 66727 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3 (By
similarity)
Mass spectrometry: Mass=66637.9; Method=Unknown; Range=1-564; Source=PubMed:17322308;
Mass spectrometry: Mass=66640.2; Mass_error=0.5; Method=MALDI; Range=1-564; Source=PubMed:18599441;
Sequence caution: Sequence=CAG30322.1; Type=Erroneous initiation; Sequence=CAX14899.1; Type=Erroneous initiation;
Secondary accessions: B2RDG6 B4DYB2 G8JLH4 Q53HQ1 Q53HT4 Q5QTR1 Q5TI15 Q6ICD2
Alternative splicing: 2 isoforms:  Q9Y262-1   Q9Y262-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EIF3L: NX_Q9Y262

Explore proteomics data for EIF3L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys101, Lys403, Lys419, Lys437
  • Modification sites at PhosphoSitePlus

  • See EIF3L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229852.1  NP_057175.1  

    ENSEMBL proteins: 
     ENSP00000416892   ENSP00000410576   ENSP00000371099   ENSP00000393822   ENSP00000398176  
     ENSP00000384634   ENSP00000390271   ENSP00000412349  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019382 eIF3l

    Graphical View of Domain Structure for InterPro Entry Q9Y262

    ProtoNet protein and cluster: Q9Y262

    UniProtKB/Swiss-Prot: EIF3L_HUMAN, Q9Y262
    Similarity: Belongs to the eIF-3 subunit L family


    EIF3L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3L_HUMAN, Q9Y262
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI18599441
    GO:0044822poly(A) RNA binding IDA--
         
    EIF3L for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-320a (MIRT044708), hsa-mir-7-5p (MIRT047761), hsa-mir-340-3p (MIRT043850), hsa-mir-124-3p (MIRT023148), hsa-mir-769-3p (MIRT039077), hsa-mir-19b-3p (MIRT050632)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3L_HUMAN, Q9Y262: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001650fibrillar center IEA--
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308

    EIF3L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3L
    Interactions:

        Search GeneGlobe Interaction Network for EIF3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3L (Q9Y2621, 2, 3 ENSP000004168924) via UniProtKB, MINT, STRING, and/or I2D (see all 629)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS3P233962, 3, ENSP000002785724MINT-7945693 I2D: score=5 STRING: ENSP00000278572
    DNM2P505702, 3, ENSP000003527214MINT-7945693 I2D: score=3 STRING: ENSP00000352721
    EIF3EP602282, 3, ENSP000002208494MINT-7945693 I2D: score=2 STRING: ENSP00000220849
    EIF3HO153722, 3, ENSP000002766824MINT-7945693 I2D: score=1 STRING: ENSP00000276682
    EEF1A1P681042, 3MINT-7945693 I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006413translational initiation IDA17581632
    GO:0006446regulation of translational initiation IEA--

    EIF3L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for EIF3L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EIF3L gene (2 alternative transcripts): 
    NM_001242923.1  NM_016091.3  

    Unigene Cluster for EIF3L:

    Eukaryotic translation initiation factor 3, subunit L
    Hs.446852  [show with all ESTs]
    Unigene Representative Sequence: AK056129
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412331(uc003auf.3 uc011ann.2) ENST00000439997 ENST00000476955
    ENST00000381683 ENST00000414316 ENST00000436452 ENST00000477256 ENST00000406934(uc003aug.3)
    ENST00000451427 ENST00000464790 ENST00000482600 ENST00000450376 ENST00000460638

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      QuantiTect SYBR Green Assays in human, mouse, rat EIF3L
      QuantiFast Probe-based Assays in human, mouse, rat EIF3L

    Additional mRNA sequence: 

    AF077207.1 AF083243.1 AF109359.1 AK056129.1 AK098457.1 AK098713.1 AK129648.1 AK222496.1 
    AK222529.1 AK293629.1 AK298776.1 AK301323.1 AK302346.1 AK315533.1 AL357455.1 BC001101.2 
    BC007510.2 BC011448.2 BC029265.1 CR456436.1 

    Selected DOTS entries (see all 181):

    DT.102840387  DT.100860685  DT.97852923  DT.95326200  DT.95295370  DT.100840438  DT.100739259  DT.120637037 
    DT.100640071  DT.100739285  DT.120637092  DT.95107293  DT.91836677  DT.100739267  DT.100739255  DT.120636993 
    DT.100871424  DT.120637032  DT.100876188  DT.100739301  DT.100639324  DT.120637148  DT.95326203  DT.95129274 

    Selected AceView cDNA sequences (see all 2747):

    BM809251 BP335456 BE255968 BQ920641 BI767887 BE305101 BM018809 CD512847 
    BE378397 BP367697 BG768818 AA714491 BX449655 BU931930 AA481331 BM828052 
    AI375911 CB850931 BQ217451 BQ065316 AI075148 BX449741 BQ883813 CB153979 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF3L (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
    SP1:                    -     -           -                 -           -                                                                                       
    SP2:                    -     -           -                 -     -     -                                                                                       
    SP3:                    -     -           -                             -                                                                                       
    SP4:                                      -                 -           -                                                                                       
    SP5:                    -     -                             -           -                                                                                       

    ExUns: 13 ^ 14
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for EIF3L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCACATCG
    EIF3L Expression
    About this image


    EIF3L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    EIF3L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446852
        Custom PCR Arrays for EIF3L
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3L gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3l1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 88.89(n)1
    99.11(a)1
      15 (37.70 cM)5
    2236911  NM_145139.21  NP_660121.21 
     790752235 
    chicken
    (Gallus gallus)
    Aves EIF3L1 eukaryotic translation initiation factor 3, subunit more 84.63(n)
    97.87(a)
      418033  NM_001012535.2  NP_001012553.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3L6
    eukaryotic translation initiation factor 3, subuni...
    96(a)
    1 ↔ 1
    GL343460.1(28446-38357)
    African clawed frog
    (Xenopus laevis)
    Amphibia eif3s6ip-prov2 eukaryotic translation initiation factor 3, subunit more 80.96(n)    BC042253.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266632 Danio rerio cDNA clone MGC64147 IMAGE6797018, complete more 80.72(n)    BC054626.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56421 CG5642 60.68(n)
    56.52(a)
      39386  NM_140296.3  NP_648553.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C17G10.96
    C03H5.56
    Protein C03H5.5 (C03H5.5) mRNA, complete cds
    41(a)
    17(a)
    many → 1
    many → 1
    II(5619590-5622483) WBGene00015920
    II(382273-385354) WBGene00015407
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G257571 AT5G25757 57.36(n)
    48.63(a)
      832644  NM_147918.4  NP_680223.1 
    rice
    (Oryza sativa)
    Liliopsida Os.100332 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.91(n)    AK068760.1 


    ENSEMBL Gene Tree for EIF3L (if available)
    TreeFam Gene Tree for EIF3L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3L gene
    Selected SIMAP similar genes for EIF3L using alignment to 11 protein entries:     EIF3L_HUMAN (see all proteins) (see all similar genes):
    SPECC1L-ADORA2A    COL24A1    KNSTRN    MPP4    KLHL2    PLEKHH2
    TMEM44    UTY    FAM210A    FAM78A    GDA    KANK3
    KDM5B    NF2    CHID1    DCTN5    ZNF20    ZNF738

    EIF3L for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for EIF3L
    PGOHUM00000238414 PGOHUM00000238751 PGOHUM00000248245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3L (see all 863)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844738981,2
    --38245845(+) GTTGTA/GTTGTC 2 -- int10--------
    rs1464451441,2
    --38245869(+) TGTCCC/TTTTTC 2 -- int10--------
    rs1408808011,2
    --38245895(+) TTCCTC/GAAAGG 2 -- int10--------
    rs1133446721,2
    C--38245938(+) TAGCTC/ATCTGC 2 -- int12Minor allele frequency- A:0.04CSA WA 120
    rs1887008411,2
    C--38245988(+) ACTTGA/GCGGCT 2 -- int10--------
    rs2004109181,2
    --38246007(+) CTGTGA/TCTCTT 2 -- int10--------
    rs1128056051,2
    C--38246019(+) CCTTCG/TAGGCG 2 -- int10--------
    rs1446229881,2
    C--38246048(+) TATCCC/TAGCGA 4 P syn10--------
    rs1466627291,2
    C--38246097(+) GCTGAA/GTACTC 2 -- int10--------
    rs1404167151,2
    --38246163(+) TTGCTC/TTTTGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for EIF3L (38244875 - 38285414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for EIF3L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724220CNV Deletion23290073
    esv2661617CNV Deletion23128226
    nsv915035CNV Loss21882294
    nsv191391CNV Loss16902084
    dgv4965n71CNV Loss21882294
    dgv1406e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF3L
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for EIF3L:    
    About MalaCards
    malaria


    EIF3L for disorders           About GeneDecksing

    Genetic Association Database (GAD): EIF3L

    Export disorders for EIF3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3L gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with EIF3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. (PubMed id 11590142)1, 2, 3 Morris-Desbois C.... Jalinot P. (J. Biol. Chem. 2001)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)
    5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PubMed id 12393749)1, 2 Yuan X.... Grummt I. (EMBO Rep. 2002)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51386 HGNC: 18138 AceView: EIF3S6IP Ensembl:ENSG00000100129 euGenes: HUgn51386
    ECgene: EIF3L H-InvDB: EIF3L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF3L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF3L gene:
    Search GeneIP for patents involving EIF3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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