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Aliases for EIF3L Gene

Aliases for EIF3L Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit L 2 3 5
  • Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein 3 4
  • Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit L 2 3
  • EIF3S6IP 3 4
  • EIF3EIP 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 Interacting Protein 2
  • Eukaryotic Translation Initiation Factor 3, Subunit E Interacting Protein 2
  • EIEF Associated Protein HSPC021 3
  • EIF3S11 3
  • HSPC021 3
  • HSPC025 3
  • MSTP005 3
  • EIF3l 4

External Ids for EIF3L Gene

Previous HGNC Symbols for EIF3L Gene

  • EIF3S6IP
  • EIF3EIP

Previous GeneCards Identifiers for EIF3L Gene

  • GC22P036575
  • GC22P038244
  • GC22P021211

Summaries for EIF3L Gene

GeneCards Summary for EIF3L Gene

EIF3L (Eukaryotic Translation Initiation Factor 3 Subunit L) is a Protein Coding gene. Diseases associated with EIF3L include Yellow Fever. Among its related pathways are Gene Expression and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3L Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3L Gene

Genomics for EIF3L Gene

Regulatory Elements for EIF3L Gene

Enhancers for EIF3L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF3L on UCSC Golden Path with GeneCards custom track

Promoters for EIF3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF3L on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF3L Gene

Chromosome:
22
Start:
37,848,448 bp from pter
End:
37,889,407 bp from pter
Size:
40,960 bases
Orientation:
Plus strand

Genomic View for EIF3L Gene

Genes around EIF3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3L Gene

Proteins for EIF3L Gene

  • Protein details for EIF3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y262-EIF3L_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit L
    Protein Accession:
    Q9Y262
    Secondary Accessions:
    • B2RDG6
    • B4DYB2
    • G8JLH4
    • Q53HQ1
    • Q53HT4
    • Q5QTR1
    • Q5TI15
    • Q6ICD2

    Protein attributes for EIF3L Gene

    Size:
    564 amino acids
    Molecular mass:
    66727 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
    SequenceCaution:
    • Sequence=CAG30322.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX14899.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF3L Gene

    Alternative splice isoforms for EIF3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3L Gene

Proteomics data for EIF3L Gene at MOPED

Post-translational modifications for EIF3L Gene

  • Ubiquitination at Lys 101, Lys 403, and Lys 419
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3L Gene

Domains & Families for EIF3L Gene

Gene Families for EIF3L Gene

Protein Domains for EIF3L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y262

UniProtKB/Swiss-Prot:

EIF3L_HUMAN :
  • Belongs to the eIF-3 subunit L family.
Family:
  • Belongs to the eIF-3 subunit L family.
genes like me logo Genes that share domains with EIF3L: view

Function for EIF3L Gene

Molecular function for EIF3L Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Ontology (GO) - Molecular Function for EIF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16189514
genes like me logo Genes that share ontologies with EIF3L: view
genes like me logo Genes that share phenotypes with EIF3L: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3L Gene

Localization for EIF3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3L Gene COMPARTMENTS Subcellular localization image for EIF3L gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EIF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IEA --
GO:0005730 nucleolus IEA --
GO:0016020 membrane IDA 19946888
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3L: view

Pathways & Interactions for EIF3L Gene

genes like me logo Genes that share pathways with EIF3L: view

Gene Ontology (GO) - Biological Process for EIF3L Gene

None

No data available for SIGNOR curated interactions for EIF3L Gene

Drugs & Compounds for EIF3L Gene

No Compound Related Data Available

Transcripts for EIF3L Gene

Unigene Clusters for EIF3L Gene

Eukaryotic translation initiation factor 3, subunit L:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: -

ExUns: 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for EIF3L Gene

GeneLoc Exon Structure for
EIF3L
ECgene alternative splicing isoforms for
EIF3L

Expression for EIF3L Gene

mRNA expression in normal human tissues for EIF3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3L Gene

This gene is overexpressed in Saliva (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3L Gene



SOURCE GeneReport for Unigene cluster for EIF3L Gene Hs.446852

genes like me logo Genes that share expression patterns with EIF3L: view

Protein tissue co-expression partners for EIF3L Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3L Gene

Orthologs for EIF3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF3L 35
  • 93.03 (n)
  • 99.65 (a)
EIF3L 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3L 35
  • 92.08 (n)
  • 99.82 (a)
EIF3L 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3l 35
  • 88.89 (n)
  • 99.11 (a)
Eif3l 16
Eif3l 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF3L 35
  • 99.53 (n)
  • 99.82 (a)
EIF3L 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3L 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3L 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3L 35
  • 84.63 (n)
  • 97.87 (a)
EIF3L 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3L 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3l 35
  • 81.49 (n)
  • 95.37 (a)
MGC75896 35
African clawed frog
(Xenopus laevis)
Amphibia eif3s6ip-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26663 35
eif3s6ip 35
  • 80.17 (n)
  • 92.29 (a)
eif3s6ip 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8938 35
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3L_ANOGA 35
  • 63.11 (n)
  • 59.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5642 35
  • 60.68 (n)
  • 56.52 (a)
CG5642 36
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C03H5.5 36
  • 17 (a)
OneToMany
C17G10.9 36
  • 41 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25757 35
  • 57.36 (n)
  • 48.63 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2732 35
rice
(Oryza sativa)
Liliopsida Os.10033 35
Os01g0229100 35
  • 56.34 (n)
  • 47.61 (a)
corn
(Zea mays)
Liliopsida Zm.5792 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3552 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06279 35
  • 59.34 (n)
  • 52.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11291 36
  • 61 (a)
OneToOne
Species with no ortholog for EIF3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3L Gene

ENSEMBL:
Gene Tree for EIF3L (if available)
TreeFam:
Gene Tree for EIF3L (if available)

Paralogs for EIF3L Gene

Pseudogenes.org Pseudogenes for EIF3L Gene

genes like me logo Genes that share paralogs with EIF3L: view

No data available for Paralogs for EIF3L Gene

Variants for EIF3L Gene

Sequence variations from dbSNP and Humsavar for EIF3L Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_053937 -
rs8646 -- 37,888,529(-) TTTCA(C/T)GGTAG utr-variant-3-prime
rs9466 -- 37,877,742(+) CGTAT(C/T)GATGA reference, synonymous-codon
rs2157472 -- 37,855,679(+) CTGAG(C/T)GGAAT intron-variant
rs2179227 -- 37,888,041(+) TTTCT(A/G)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3L Gene

Variant ID Type Subtype PubMed ID
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
nsv191391 CNV Loss 16902084
esv2661617 CNV Deletion 23128226
esv2724220 CNV Deletion 23290073

Variation tolerance for EIF3L Gene

Residual Variation Intolerance Score: 7.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EIF3L Gene

Disorders for EIF3L Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF3L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
yellow fever
  • jungle yellow fever
- elite association - COSMIC cancer census association via MalaCards
Search EIF3L in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF3L

Genetic Association Database (GAD)
EIF3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3L
genes like me logo Genes that share disorders with EIF3L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3L Gene

Publications for EIF3L Gene

  1. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. (PMID: 11590142) Morris-Desbois C. … Jalinot P. (J. Biol. Chem. 2001) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for EIF3L Gene

Sources for EIF3L Gene

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