EIF3L Gene
protein-coding GIFtS: 46
GCID: GC22P038244
|
|
eukaryotic translation initiation factor 3, subunit L(Previous names: eukaryotic translation initiation factor 3, subunit 6 interacting...)
(Previous symbols: EIF3S6IP, EIF3EIP)
| |
Aliases
for EIF3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 3, Subunit L1 2 | | Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein2 3 | | EIF3EIP1 2 3 | | Eukaryotic Translation Initiation Factor 3, Subunit 6 Interacting Protein1 | | EIF3S6IP1 2 3 | | Eukaryotic Translation Initiation Factor 3, Subunit E Interacting Protein1 | | EIF3S111 2 | | MSTP0052 | | HSPC0211 2 | | EIEF Associated Protein HSPC0212 | | HSPC0251 2 | | Eukaryotic Translation Initiation Factor 3 Subunit L2 | | Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein2 3 | | EIF3l1 |
Export aliases for EIF3L gene to outside databasesPrevious GC identifers: GC22P036575 GC22P021211 |
Summaries
for EIF3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EIF3L_HUMAN, Q9Y262Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
Gene Wiki entry for EIF3L (EIF3EIP)
|
Genomic Views
for EIF3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EIF3L gene promoter:
ISGF-3 Pax-5 Arnt CBF-C CBF-A CBF-B CP1A CP1C NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF3L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22qEIF3L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P038244: view genomic region
(about GC identifiers)
Start:
|
38,244,875 bp from pter |
End:
|
38,285,414 bp from pter |
Size:
|
40,540 bases |
Orientation:
|
plus strand |
|
Proteins
for EIF3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EIF3L_HUMAN, Q9Y262 (See
protein sequence)Recommended Name: Eukaryotic translation initiation factor 3 subunit L Size: 564 amino acids; 66727 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits:EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complexappears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed ofEIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C bindsEIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds tothe eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion.Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading tophosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3 (By similarity)
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=66637.9; Method=Unknown; Range=1-564; Source=PubMed:17322308;
Mass spectrometry: Mass=66640.2; Mass_error=0.5; Method=MALDI; Range=1-564; Source=PubMed:18599441;
Sequence caution: Sequence=CAG30322.1; Type=Erroneous initiation; Sequence=CAX14899.1; Type=Erroneous initiation;
Secondary accessions: B2RDG6 B4DYB2 G8JLH4 Q53HQ1 Q53HT4 Q5QTR1 Q5TI15 Q6ICD2Alternative splicing: 2 isoforms: Q9Y262-1 Q9Y262-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for EIF3L: NX_Q9Y262
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y262
EIF3L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001229852.1 NP_057175.1
ENSEMBL proteins: ENSP00000416892 ENSP00000410576 ENSP00000393822 ENSP00000398176 ENSP00000384634 ENSP00000390271 ENSP00000412349 ENSP00000400645 ENSP00000371099 ENSP00000262832
Human Recombinant Protein Products for EIF3L:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
EIF3L for ontologies About GeneDecksing
EIF3L Antibody Products:
Assay Products for EIF3L: |
Protein
Domains /
Families
for EIF3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF3L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y262ProtoNet protein and cluster: Q9Y262 UniProtKB/Swiss-Prot: EIF3L_HUMAN, Q9Y262Similarity: Belongs to the eIF-3 subunit L family |
Function
for EIF3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EIF3L_HUMAN, Q9Y262Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003743 | contributes to translation initiation factor activity |
IDA | 17581632 | | GO:0005515 | protein binding |
IPI | -- |
EIF3L for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EIF3L (NM_016091) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3L |
|
Pathways & Interactions
for EIF3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/602 Interacting proteins for EIF3L (Q9Y2621, 2, 3 ENSP000004168924) via UniProtKB, MINT, STRING, and/or I2D (see all 602)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RPS3 | P233962, 3, ENSP000002785724 | MINT-7945693 I2D:
score=5 STRING: ENSP00000278572 | | DNM2 | P505702, 3, ENSP000003527214 | MINT-7945693 I2D:
score=3 STRING: ENSP00000352721 | | EIF3E | P602282, 3, ENSP000002208494 | MINT-7945693 I2D:
score=2 STRING: ENSP00000220849 | | EIF3H | O153722, 3, ENSP000002766824 | MINT-7945693 I2D:
score=1 STRING: ENSP00000276682 | | NUP155 | O756942, 3, ENSP000002314984 | MINT-7945693 I2D:
score=1 STRING: ENSP00000231498 |
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
EIF3L for ontologies About GeneDecksing
|
Drugs & Compounds
for EIF3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EIF3L
Search CenterWatch for drugs/clinical trials and news about EIF3L
|
Transcripts
for EIF3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EIF3L gene (2 alternative transcripts): NM_001242923.1 NM_016091.3 Unigene Cluster for EIF3L: Eukaryotic translation initiation factor 3, subunit L Hs.446852 [show with all ESTs]Unigene Representative Sequence: AK05612915 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000412331(uc003auf.3 uc011ann.2) ENST00000439997 ENST00000476955
ENST00000414316 ENST00000436452 ENST00000477256 ENST00000406934(uc003aug.3)
ENST00000451427 ENST00000464790 ENST00000482600 ENST00000450376 ENST00000460638
ENST00000425539 ENST00000381683 ENST00000262832
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EIF3L (NM_016091) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3L |
Additional cDNA sequence: AF077207.1 AF083243.1 AF109359.1 AK056129.1 AK098457.1 AK098713.1 AK129648.1 AK222496.1 AK222529.1 AK293629.1 AK298776.1 AK301323.1 AK302346.1 AK315533.1 AL357455.1 BC001101.2 BC007510.2 BC011448.2 BC029265.1 CR456436.1 24/181 DOTS entries (see all 181): DT.102840387 DT.100860685 DT.97852923 DT.95326200 DT.95295370 DT.100840438 DT.100739259 DT.120637037 DT.100640071 DT.100739285 DT.120637092 DT.95107293 DT.91836677 DT.100739267 DT.100739255 DT.120636993 DT.100871424 DT.120637032 DT.100876188 DT.100739301 DT.100639324 DT.120637148 DT.95326203 DT.95129274 24/2747 AceView cDNA sequences (see all 2747): CB054841 BQ961273 BX424552 BM757108 CB123564 BM828052 BP342092 CR603334 CF552437 CB119252 CB125326 AA514294 BP374401 BQ278187 BQ949597 BX408594 BX438621 BU197369 BM462544 BF094625 AA470408 BP377508 BP382118 BE742211
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3L (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for EIF3L
|
Expression
for EIF3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCACATCG
About this image
See EIF3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF3L
SOURCE GeneReport for Unigene cluster: Hs.446852
SABiosciences Custom PCR Arrays for EIF3L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3L |
Orthologs
for EIF3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF3L gene from 9/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Eif3l1 , 5 |
eukaryotic translation initiation factor 3, subunit more1, 5 |
88.89(n)1
99.11(a)1 |
|
15 (37.70 cM)5
2236911 NM_145139.21 NP_660121.21
790752235 |
chicken
(Gallus gallus) |
Aves |
EIF3L1 |
eukaryotic translation initiation factor 3, subunit more |
84.63(n)
97.87(a) |
|
418033 NM_001012535.1 NP_001012553.1 |
lizard
(Anolis carolinensis) |
Reptilia |
EIF3L6 |
-- |
99(a) |
1 ↔ 1 |
GL343460.1(28669-38357) |
African clawed frog
(Xenopus laevis) |
Amphibia |
eif3s6ip-prov2 |
eukaryotic translation initiation factor 3, subunit more |
80.96(n) |
|
BC042253.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.266632 |
Danio rerio cDNA clone MGC64147 IMAGE6797018, complete more |
80.72(n) |
|
BC054626.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG56421 |
CG5642 |
60.8(n)
56.63(a) |
|
39386 NM_140296.2 NP_648553.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
C17G10.91 |
hypothetical protein |
52.47(n)
45.72(a) |
|
173950 NM_170996.4 NP_740994.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G257571 |
RNA polymerase I-associated factor PAF67 |
57.43(n)
48.63(a) |
|
832644 NM_147918.4 NP_680223.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.100332 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
78.91(n) |
|
AK068760.1 |
ENSEMBL Gene Tree for EIF3L (if available)
TreeFam Gene Tree for EIF3L (if available) |
Paralogs
for EIF3L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EIF3L gene
18/49 SIMAP similar genes for EIF3L using alignment to 10 protein entries: EIF3L_HUMAN (see all proteins)
(see all similar genes):COL24A1 KNSTRN MPP4 KLHL2 PLEKHH2 TMEM44
UTY FAM210A FAM78A GDA KANK3 NF2
CHID1 DCTN5 USP10 WDR27 RBMS2 AURA2
EIF3L for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for EIF3L
PGOHUM00000238414 PGOHUM00000238751 PGOHUM00000248245
|
Genomic Variants
for EIF3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EIF3L (38244875 - 38285414 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for EIF3L
2 CNVs: 4128 6149 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF3L |
|
Disorders
/ Diseases
for EIF3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EIF3L for disorders About GeneDecksing
1  disease for EIF3L: About MalaCardsmalaria
Export disorders for EIF3L gene to outside databases
|
Publications
for EIF3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EIF3L gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with EIF3L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. (PubMed id 11590142)1, 2, 3 Morris-Desbois C....Jalinot P. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M....Robinson C.V. (2008)
- Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (2007)
- Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E....Leary J.A. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PubMed id 12393749)1, 2 Yuan X.... Grummt I. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
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External Searches for EIF3L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing EIF3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing EIF3L gene
(According to HUGE)
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Specialized Databases showing EIF3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for EIF3L | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for EIF3L gene:
Search GeneIP for patents involving EIF3L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EIF3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EIF3L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF3L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3L | | | OriGene Protein Over-expression Lysate for EIF3L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EIF3L | | OriGene 3'-UTR Clone for EIF3L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EIF3L | | OriGene Custom Protein Services for EIF3L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EIF3L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF3L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3L |
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| | | | Search Tocris compounds for EIF3L |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3L |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3L |
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