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Aliases for EIF3K Gene

Aliases for EIF3K Gene

  • Eukaryotic Translation Initiation Factor 3, Subunit K 2 3
  • EIF3S12 3 4 6
  • Eukaryotic Translation Initiation Factor 3, Subunit 12 2 3
  • Muscle-Specific Gene M9 Protein 3 4
  • EIF-3 P28 3 4
  • PLAC-24 3 4
  • PLAC24 3 6
  • Eukaryotic Translation Initiation Factor 3 Subunit 12 4
  • Eukaryotic Translation Initiation Factor 3 Subunit K 3
  • Muscle Specific 3
  • EIF-3 P25 4
  • EIF3-P28 3
  • HSPC029 3
  • MSTP001 3
  • PRO1474 3
  • ARG134 3
  • PTD001 3
  • EIF3k 4
  • M9 3

External Ids for EIF3K Gene

Previous Symbols for EIF3K Gene

  • EIF3S12

Summaries for EIF3K Gene

Entrez Gene Summary for EIF3K Gene

  • The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]

GeneCards Summary for EIF3K Gene

EIF3K (Eukaryotic Translation Initiation Factor 3, Subunit K) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include translation initiation factor activity and ribosome binding.

UniProtKB/Swiss-Prot for EIF3K Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3K Gene

Genomics for EIF3K Gene

Genomic Location for EIF3K Gene

Start:
38,619,082 bp from pter
End:
38,636,955 bp from pter
Size:
17,874 bases
Orientation:
Plus strand

Genomic View for EIF3K Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF3K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3K Gene

Regulatory Elements for EIF3K Gene

Proteins for EIF3K Gene

  • Protein details for EIF3K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBQ5-EIF3K_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit K
    Protein Accession:
    Q9UBQ5
    Secondary Accessions:
    • A8K0I9
    • B7ZAM9
    • Q96IQ0
    • Q9Y6D1

    Protein attributes for EIF3K Gene

    Size:
    218 amino acids
    Molecular mass:
    25060 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.

    Three dimensional structures from OCA and Proteopedia for EIF3K Gene

    Alternative splice isoforms for EIF3K Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3K Gene

Proteomics data for EIF3K Gene at MOPED

Post-translational modifications for EIF3K Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys13, Lys16, and Lys38

No data available for DME Specific Peptides for EIF3K Gene

Domains for EIF3K Gene

UniProtKB/Swiss-Prot:

EIF3K_HUMAN
Family:
  • Belongs to the eIF-3 subunit K family.:
    • Q9UBQ5
genes like me logo Genes that share domains with EIF3K: view

No data available for Gene Families for EIF3K Gene

Function for EIF3K Gene

Molecular function for EIF3K Gene

UniProtKB/Swiss-Prot Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Ontology (GO) - Molecular Function for EIF3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IDA 17581632
GO:0005488 binding --
GO:0005515 protein binding IPI 16189514
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with EIF3K: view

miRNA for EIF3K Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF3K Gene

Localization for EIF3K Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3K Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3K Gene COMPARTMENTS Subcellular localization image for EIF3K gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for EIF3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EIF3K: view

Pathways for EIF3K Gene

genes like me logo Genes that share pathways with EIF3K: view

Gene Ontology (GO) - Biological Process for EIF3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with EIF3K: view

Transcripts for EIF3K Gene

Unigene Clusters for EIF3K Gene

Eukaryotic translation initiation factor 3, subunit K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3K Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3:
SP4: -

Relevant External Links for EIF3K Gene

GeneLoc Exon Structure for
EIF3K
ECgene alternative splicing isoforms for
EIF3K

Expression for EIF3K Gene

mRNA expression in normal human tissues for EIF3K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3K Gene

SOURCE GeneReport for Unigene cluster for EIF3K Gene Hs.314359

mRNA Expression by UniProt/SwissProt for EIF3K Gene

Q9UBQ5-EIF3K_HUMAN
Tissue specificity: Ubiquitous, with the highest levels of expression in brain, testis and kidney.
genes like me logo Genes that share expressions with EIF3K: view

Orthologs for EIF3K Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3K 36
  • 99.85 (n)
  • 100 (a)
EIF3K 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3K 36
  • 93.43 (n)
  • 99.54 (a)
EIF3K 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3K 36
  • 93.12 (n)
  • 99.54 (a)
EIF3K 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3k 36
  • 91.44 (n)
  • 98.62 (a)
Eif3k 16
Eif3k 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3K 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3K 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3k 36
  • 91 (n)
  • 96 (a)
chicken
(Gallus gallus)
Aves EIF3K 37
  • 65 (a)
OneToOne
LOC101750374 36
  • 84.53 (n)
  • 92.34 (a)
lizard
(Anolis carolinensis)
Reptilia EIF3K 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6031 36
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3k 36
  • 77.83 (n)
  • 91.28 (a)
Str.1712 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10371 36
zebrafish
(Danio rerio)
Actinopterygii eif3k 36
  • 78.29 (n)
  • 84.65 (a)
eif3k 37
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3K_ANOGA 36
  • 59.02 (n)
  • 51.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10306 36
  • 58.37 (n)
  • 48.78 (a)
CG10306 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eif-3.K 36
  • 48.37 (n)
  • 38.6 (a)
eif-3.K 37
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3K 36
  • 48.73 (n)
  • 35.03 (a)
rice
(Oryza sativa)
Liliopsida Os03g0182700 36
  • 48.59 (n)
  • 33.83 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09707 36
  • 46.54 (n)
  • 30.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3028 37
  • 49 (a)
OneToOne
Species with no ortholog for EIF3K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3K Gene

ENSEMBL:
Gene Tree for EIF3K (if available)
TreeFam:
Gene Tree for EIF3K (if available)

Paralogs for EIF3K Gene

Pseudogenes.org Pseudogenes for EIF3K Gene

genes like me logo Genes that share paralogs with EIF3K: view

No data available for Paralogs for EIF3K Gene

Variants for EIF3K Gene

Sequence variations from dbSNP and Humsavar for EIF3K Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs888994 -- 38,624,912(-) TCCCT(C/T)CCCTG intron-variant
rs1060776 -- 38,633,199(+) GAGCT(A/G)GGGGT intron-variant
rs1136572 -- 38,632,324(-) ggtct(C/T)gaatt intron-variant
rs1136573 -- 38,632,297(-) CTTCC(C/T)GCCTC intron-variant
rs1136574 -- 38,632,191(-) TGATC(C/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3K Gene

Variant ID Type Subtype PubMed ID
nsv470140 CNV Gain 18288195
nsv833826 CNV Loss 17160897
nsv833827 CNV Gain 17160897
nsv833828 CNV Loss 17160897
nsv911667 CNV Gain 21882294

Relevant External Links for EIF3K Gene

HapMap Linkage Disequilibrium report
EIF3K

Disorders for EIF3K Gene

No disorders were found for EIF3K Gene.

No data available for UniProtKB/Swiss-Prot for EIF3K Gene

Publications for EIF3K Gene

  1. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3. (PMID: 14519125) Mayeur G.L. … Hershey J.W.B. (Eur. J. Biochem. 2003) 2 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. Crystal structure of human eIF3k, the first structure of eIF3 subunits. (PMID: 15180986) Wei Z. … Gong W. (J. Biol. Chem. 2004) 3 4
  4. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. (PMID: 15327989) Shen X. … Gu J. (FEBS Lett. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for EIF3K Gene

Sources for EIF3K Gene

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