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EIF3K Gene

protein-coding   GIFtS: 57
GCID: GC19P039109

Eukaryotic Translation Initiation Factor 3, Subunit K

(Previous names: eukaryotic translation initiation factor 3, subunit 12)
(Previous symbol: EIF3S12)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit K1 2     EIF3-p282
EIF3S121 2 3 5     HSPC0292
Eukaryotic Translation Initiation Factor 3, Subunit 121 2     M92
Eukaryotic Translation Initiation Factor 3 Subunit 122 3     MSTP0012
Muscle-Specific Gene M9 Protein2 3     PRO14742
PLAC-242 3     PTD0012
EIF-3 P252 3     Eukaryotic Translation Initiation Factor 3 Subunit K2
EIF-3 P282 3     Muscle Specific2
PLAC242 5     eIF3k3

External Ids:    HGNC: 246561   Entrez Gene: 273352   Ensembl: ENSG000001789827   OMIM: 6095965   UniProtKB: Q9UBQ53   

Export aliases for EIF3K gene to outside databases

Previous GC identifers: GC19P043803 GC19P035556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF3K Gene:
The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits,
including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit
and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 (PubMed 14519125)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for EIF3K Gene:
EIF3K (eukaryotic translation initiation factor 3, subunit K) is a protein-coding gene. GO annotations related to this gene include ribosome binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: EIF3K_HUMAN, Q9UBQ5
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3K Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3K gene promoter:
         SRF   Brachyury   HTF   SRF (504 AA)   c-Ets-1   E47   Hand1   c-Myb   Zic3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3K promoter sequence
   Search Chromatin IP Primers for EIF3K

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

EIF3K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3K gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039109:  view genomic region     (about GC identifiers)

Start:
39,109,722 bp from pter      End:
39,127,595 bp from pter
Size:
17,874 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EIF3K_HUMAN, Q9UBQ5 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit K  
Size: 218 amino acids; 25060 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but
not with CCND1 and CCND2
Mass spectrometry: Mass=24970.6; Method=Unknown; Range=1-218; Source=PubMed:17322308;
Mass spectrometry: Mass=24971.1; Mass_error=0.2; Method=MALDI; Range=1-218; Source=PubMed:18599441;
1 PDB 3D structure from and Proteopedia for EIF3K:
1RZ4 (3D)    
Secondary accessions: A8K0I9 Q96IQ0 Q9Y6D1

Explore the universe of human proteins at neXtProt for EIF3K: NX_Q9UBQ5

Explore proteomics data for EIF3K at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys16, Lys38
  • Modification sites at PhosphoSitePlus

  • See EIF3K Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037366.1  
    ENSEMBL proteins: 
     ENSP00000465460   ENSP00000248342   ENSP00000440999   ENSP00000468525   ENSP00000438145  
     ENSP00000464827   ENSP00000466609   ENSP00000467895   ENSP00000468231  
    Reactome Protein details: Q9UBQ5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR016020 Transl_init_fac_sub12_N_euk
     IPR009374 eIF3k
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9UBQ5

    ProtoNet protein and cluster: Q9UBQ5

    1 Blocks protein domain: IPB009374 Eukaryotic translation initiation factor 3 subunit 11

    UniProtKB/Swiss-Prot: EIF3K_HUMAN, Q9UBQ5
    Similarity: Belongs to the eIF-3 subunit K family


    Find genes that share domains with EIF3K           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3K_HUMAN, Q9UBQ5
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0043022ribosome binding IEA--
         
    Find genes that share ontologies with EIF3K           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EIF3K

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    miRTarBase miRNAs that target EIF3K:
    hsa-mir-744-5p (MIRT037589), hsa-mir-421 (MIRT016103), hsa-mir-16-5p (MIRT031817), hsa-mir-92a-3p (MIRT049261)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3K_HUMAN, Q9UBQ5: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--

    Find genes that share ontologies with EIF3K           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3K About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with EIF3K           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Reactome Pathways for EIF3K (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3K
    Interactions:

        GeneGlobe Interaction Network for EIF3K

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3K (Q9UBQ51, 2, 3 ENSP000002483424) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCND3P302812, 3, ENSP000003620824MINT-50583 MINT-50582 MINT-50584 I2D: score=3 STRING: ENSP00000362082
    EIF3LQ9Y2622, 3, ENSP000004168924MINT-66591 I2D: score=14 STRING: ENSP00000416892
    EIF3HO153723, ENSP000002766824I2D: score=3 STRING: ENSP00000276682
    CLUAP1Q96AJ13, ENSP000003443924I2D: score=2 STRING: ENSP00000344392
    EIF3CQ996133, ENSP000003326044I2D: score=2 STRING: ENSP00000332604
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with EIF3K           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for EIF3K



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF3K gene: 
    NM_013234.2  

    Unigene Cluster for EIF3K:

    Eukaryotic translation initiation factor 3, subunit K
    Hs.314359  [show with all ESTs]
    Unigene Representative Sequence: BM551450
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593149 ENST00000248342(uc002oiz.1) ENST00000586932 ENST00000593062
    ENST00000538434 ENST00000588934 ENST00000545173(uc010xuh.2) ENST00000589307
    ENST00000588422 ENST00000586513 ENST00000591409 ENST00000592558 ENST00000588299
    ENST00000590134
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    Additional mRNA sequence: 

    AB019392.1 AF077051.1 AF085358.1 AF109355.1 AF315506.1 AK026531.1 AK289554.1 AK298635.1 
    AK301035.1 AK316344.1 AY245432.1 BC001031.2 BC007335.2 BC007559.1 

    Selected DOTS entries (see all 26):

    DT.95161877  DT.454244  DT.95309593  DT.95161906  DT.100890586  DT.92466511  DT.95099074  DT.100890573 
    DT.100843790  DT.100890575  DT.100882510  DT.91649669  DT.95161862  DT.100045548  DT.95161870  DT.91837049 
    DT.121505417  DT.95161858  DT.121505425  DT.40259092  DT.95161916  DT.95161917  DT.95161926  DT.95258270 

    Selected AceView cDNA sequences (see all 755):

    BQ020768 BM458121 AA716047 BU186914 W33089 BE793981 BE378930 AA318016 
    BX100465 BM971596 BU173563 BQ004922 W32336 AI582713 AI566893 BG104296 
    BM857545 BQ937010 BM716353 BU631551 BE908706 AA918241 BQ671350 BF718294 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3K    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                            -     -     -                           
    SP2:                                            -     -                                 
    SP3:                                                                                    
    SP4:                    -                                                               


    ECgene alternative splicing isoforms for EIF3K

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3K expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCTCCC
    EIF3K Expression
    About this image


    EIF3K expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    EIF3K Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3K Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.314359

    UniProtKB/Swiss-Prot: EIF3K_HUMAN, Q9UBQ5
    Tissue specificity: Ubiquitous, with the highest levels of expression in brain, testis and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3K gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3k1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 91.44(n)1
    98.62(a)1
      7 (16.94 cM)5
    738301  NM_028659.31  NP_082935.11 
     289713735 
    chicken
    (Gallus gallus)
    Aves LOC1017503741 eukaryotic translation initiation factor 3 subunit more 84.53(n)
    92.34(a)
      101750374  XM_004950222.1  XP_004950279.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3K6
    eukaryotic translation initiation factor 3, subuni...
    77(a)
    1 ↔ 1
    GL343427.1(792573-799711)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.60312 Xenopus laevis transcribed sequence with moderate similarity more 78.12(n)    BU910973.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eif3k1 eukaryotic translation initiation factor 3, subunit more 78.29(n)
    84.65(a)
      550245  NM_001017583.1  NP_001017583.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103061 CG10306 58.37(n)
    48.78(a)
      37475  NM_137760.3  NP_611604.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.K1 eif-3.K 48.37(n)
    38.6(a)
      179779  NM_073840.5  NP_506241.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF3K1 EIF3K 48.73(n)
    35.03(a)
      829461  NM_119479.3  NP_195051.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01827001 Os03g0182700 48.59(n)
    33.83(a)
      4331842  NM_001055710.1  NP_001049175.2 


    ENSEMBL Gene Tree for EIF3K (if available)
    TreeFam Gene Tree for EIF3K (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3K gene
    Selected SIMAP similar genes for EIF3K using alignment to 11 protein entries:     EIF3K_HUMAN (see all proteins) (see all similar genes):
    ARL6IP5    TAF2    C1orf143    IK    RHOA    C12orf76
    NEK4    pp12301    GALK2    PARK2    ZNF429    ADCK1
    ARIH1    RPS13    SMYD4    VPS33A    RHBG    RRM2B

    Find genes that share paralogs with EIF3K           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for EIF3K
    PGOHUM00000237962 PGOHUM00000245665 PGOHUM00000235721


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3K (see all 422)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347806791,2
    C,F--39110649(+) CCTGAA/GCAGGG 1 -- int111Minor allele frequency- G:0.19NA CSA WA EA 553
    rs1474060171,2
    --39110859(+) TGGCCA/CGTGCC 1 -- int10--------
    rs22329981,2
    C,F,O,A,H--39110966(+) CTTGAT/GTCTCC 1 -- int18Minor allele frequency- G:0.02NS EA NA WA 670
    rs1888063901,2
    C--39111002(+) CCACCC/TTGGAG 2 L syn10--------
    rs2018835201,2
    C--39111045(+) CTATGA/GTCTGG 2 D G mis10--------
    rs1814973751,2
    C--39111083(+) AAGTGC/TCTAGC 1 -- int10--------
    rs1869012151,2
    C--39111085(+) GTGTCC/TAGCTC 1 -- int10--------
    rs22329991,2
    C,H--39111092(+) GCTCTC/TTGTCT 1 -- int14Minor allele frequency- T:0.00NS EA 420
    rs1814383201,2
    C--39111124(+) GCAGGC/GTGCCA 1 -- int10--------
    rs1859155231,2
    --39111271(+) ACTCAC/TGCCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF3K (39109722 - 39127595 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for EIF3K:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833828CNV Loss17160897
    nsv833826CNV Loss17160897
    nsv833827CNV Gain17160897
    nsv470140CNV Gain18288195
    nsv911667CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing EIF3K
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3K

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609596    OMIM disorders: --


    Find genes that share disorders with EIF3K           About GenesLikeMe


    Export disorders for EIF3K gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3K gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with EIF3K)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3. (PubMed id 14519125)1, 2, 3, 9 Mayeur G.L.... Hershey J.W.B. (Eur. J. Biochem. 2003)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)
    5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Crystal structure of human eIF3k, the first structure of eIF3 subunits. (PubMed id 15180986)1, 2 Wei Z.... Gong W. (J. Biol. Chem. 2004)
    8. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. (PubMed id 15327989)1, 2 Shen X.... Gu J. (FEBS Lett. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact. (PubMed id 12006665)1, 9 Karki S....Holzbaur E.L. (Mol. Biol. Cell 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27335 HGNC: 24656 AceView: eIF3k Ensembl:ENSG00000178982 euGenes: HUgn27335
    ECgene: EIF3K H-InvDB: EIF3K

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF3K Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EIF3K gene:
    Search GeneIP for patents involving EIF3K

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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